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Cecilio Giménez

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Cecilio Giménez; Robert J Harvey; Ignacio Ibáñez; Victoria M James; Esperanza Jiménez; Pablo Lapunzina; Carmen Aragón; Esther Arribas-González; Seo-Kyung Chung; Jaime de Juan-Sanz; Lourdes R Desviat; Enrique Fernández-Sánchez; Noemí García-Tardón; Jaime Martínez-Villarreal; Julián Nevado; Enrique Núñez; Gonzalo Pérez-Siles; Mark I Rees; Valeria Romanelli; Rhys H Thomas; Maya Topf; Francisco Zafra; Beatriz López-Corcuera
A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2.
Noemí García-Tardón; Cecilio Giménez; Inmaculada M González-González; Jaime Martínez-Villarreal; Enrique Fernández-Sánchez; Francisco Zafra
Protein kinase C (PKC)-promoted endocytosis of glutamate transporter GLT-1 requires ubiquitin ligase Nedd4-2-dependent ubiquitination but not phosphorylation.
Enrique Fernández-Sánchez; Jaime Martínez-Villarreal; Cecilio Giménez; Francisco Zafra
Constitutive and regulated endocytosis of the glycine transporter GLYT1b is controlled by ubiquitination.

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All Publications

2012: Cecilio Giménez; Robert J Harvey; Ignacio Ibáñez; Victoria M James; Esperanza Jiménez; Pablo Lapunzina; Carmen Aragón; Esther Arribas-González; Seo-Kyung Chung; Jaime de Juan-Sanz; Lourdes R Desviat; Enrique Fernández-Sánchez; Noemí García-Tardón; Jaime Martínez-Villarreal; Julián Nevado; Enrique Núñez; Gonzalo Pérez-Siles; Mark I Rees; Valeria Romanelli; Rhys H Thomas; Maya Topf; Francisco Zafra; Beatriz López-Corcuera
A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2.
The Journal of biological chemistry 2012;287(34):28986-9002.
2012: Noemí García-Tardón; Cecilio Giménez; Inmaculada M González-González; Jaime Martínez-Villarreal; Enrique Fernández-Sánchez; Francisco Zafra
Protein kinase C (PKC)-promoted endocytosis of glutamate transporter GLT-1 requires ubiquitin ligase Nedd4-2-dependent ubiquitination but not phosphorylation.
The Journal of biological chemistry 2012;287(23):19177-87.
2009: Enrique Fernández-Sánchez; Jaime Martínez-Villarreal; Cecilio Giménez; Francisco Zafra
Constitutive and regulated endocytosis of the glycine transporter GLYT1b is controlled by ubiquitination.
The Journal of biological chemistry 2009;284(29):19482-92.
2009: Inmaculada M González-González; Noemí García-Tardón; Cecilio Giménez; Francisco Zafra
Splice variants of the glutamate transporter GLT1 form hetero-oligomers that interact with PSD-95 and NMDA receptors.
Journal of neurochemistry 2009;110(1):264-74.
2008: Francisco Zafra; Cecilio Giménez
Glycine transporters and synaptic function.
IUBMB life 2008;60(12):810-7.
2008: Inmaculada M González-González; Noemí García-Tardón; Cecilio Giménez; Francisco Zafra
PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster.
Glia 2008;56(9):963-74.
2008: Inmaculada M González-González; Noemí García-Tardón; Beatriz Cubelos; Cecilio Giménez; Francisco Zafra
The glutamate transporter GLT1b interacts with the scaffold protein PSD-95.
Journal of neurochemistry 2008;105(5):1834-48.
2008: Enrique Fernández-Sánchez; F Javier Díez-Guerra; Beatriz Cubelos; Cecilio Giménez; Francisco Zafra
Mechanisms of endoplasmic-reticulum export of glycine transporter-1 (GLYT1).
The Biochemical journal 2008;409(3):669-81.
2005: Beatriz Cubelos; Inmaculada M González-González; Cecilio Giménez; Francisco Zafra
The scaffolding protein PSD-95 interacts with the glycine transporter GLYT1 and impairs its internalization.
Journal of neurochemistry 2005;95(4):1047-58.
2005: Beatriz Cubelos; Cecilio Giménez; Francisco Zafra
The glycine transporter GLYT1 interacts with Sec3, a component of the exocyst complex.
Neuropharmacology 2005;49(6):935-44.
2005: Beatriz Cubelos; Cecilio Giménez; Francisco Zafra
Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain.
Cerebral cortex (New York, N.Y. : 1991) 2005;15(4):448-59.
2005: Beatriz Cubelos; Inmaculada M González-González; Cecilio Giménez; Francisco Zafra
Amino acid transporter SNAT5 localizes to glial cells in the rat brain.
Glia 2005;49(2):230-44.
2005: Inmaculada M González-González; Beatriz Cubelos; Cecilio Giménez; Francisco Zafra
Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain.
Neuroscience 2005;130(1):61-73.
2003: Enrique Salero; Cecilio Giménez; Francisco Zafra
Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene.
The Biochemical journal 2003;370(Pt 3):979-86.
2001: Francisco Zafra; Cecilio Giménez
Molecular determinants involved in the asymmetrical distribution of glycine transporters in polarized cells.
Biochemical Society transactions 2001;29(Pt 6):746-50.
2001: Enrique Salero; R Pérez-Sen; J Aruga; Cecilio Giménez; Francisco Zafra
Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.
The Journal of biological chemistry 2001;276(3):1881-8.
2001: Rodrigo Martínez-Maza; I Poyatos; Beatriz López-Corcuera; E N úñez; Cecilio Giménez; Francisco Zafra; Carmen Aragón
The role of N-glycosylation in transport to the plasma membrane and sorting of the neuronal glycine transporter GLYT2.
The Journal of biological chemistry 2001;276(3):2168-73.
2000: Enrique Núñez; Beatriz López-Corcuera; J Vázquez; Cecilio Giménez; Carmen Aragón
Differential effects of the tricyclic antidepressant amoxapine on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters.
British journal of pharmacology 2000;129(1):200-6.
2000: I Poyatos; F Ruberti; Rodrigo Martínez-Maza; Cecilio Giménez; Carlos G Dotti; Francisco Zafra
Polarized distribution of glycine transporter isoforms in epithelial and neuronal cells.
Molecular and cellular neurosciences 2000;15(1):99-111.
1998: J Ponce; I Poyatos; Carmen Aragón; Cecilio Giménez; Francisco Zafra
Characterization of the 5' region of the rat brain glycine transporter GLYT2 gene: identification of a novel isoform.
Neuroscience letters 1998;242(1):25-8.
1998: Cecilio Giménez
[Composition and structure of the neuronal membrane: molecular basis of its physiology and pathology].
Revista de neurologia 1998;26(150):232-9.
1997: I Poyatos; J Ponce; Carmen Aragón; Cecilio Giménez; Francisco Zafra
The glycine transporter GLYT2 is a reliable marker for glycine-immunoreactive neurons.
Brain research. Molecular brain research 1997;49(1-2):63-70.
1997: Francisco Zafra; Carmen Aragón; Cecilio Giménez
Molecular biology of glycinergic neurotransmission.
Molecular neurobiology 1997;14(3):117-42.
1997: L Olivares; Carmen Aragón; Cecilio Giménez; Francisco Zafra
Analysis of the transmembrane topology of the glycine transporter GLYT1.
The Journal of biological chemistry 1997;272(2):1211-7.
1996: Maria Angel García; Jesús Vázquez; Cecilio Giménez; Fernando Valdivieso; Francisco Zafra
Transcription factor AP-2 regulates human apolipoprotein E gene expression in astrocytoma cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7550-6.
1995: Francisco Zafra; J Gomeza; L Olivares; Carmen Aragón; Cecilio Giménez
Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS.
The European journal of neuroscience 1995;7(6):1342-52.
1995: Francisco Zafra; Carmen Aragón; L Olivares; Niels Christian Danbolt; Cecilio Giménez; J Storm-Mathisen
Glycine transporters are differentially expressed among CNS cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 2):3952-69.
1995: L Olivares; Carmen Aragón; Cecilio Giménez; Francisco Zafra
The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter.
The Journal of biological chemistry 1995;270(16):9437-42.
1995: J Gomeza; Francisco Zafra; L Olivares; Cecilio Giménez; Carmen Aragón
Regulation by phorbol esters of the glycine transporter (GLYT1) in glioblastoma cells.
Biochimica et biophysica acta 1995;1233(1):41-6.
1994: L Olivares; Carmen Aragón; Cecilio Giménez; Francisco Zafra
Carboxyl terminus of the glycine transporter GLYT1 is necessary for correct processing of the protein.
The Journal of biological chemistry 1994;269(45):28400-4.
1994: Francisco Zafra; Carmen Aragón; Cecilio Giménez
Characteristics and regulation of proline transport in cultured glioblastoma cells.
The Biochemical journal 1994;302 ( Pt 3)():675-80.
1994: Mayte Villalba; Alberto Martínez-Serrano; P Gómez-Puertas; P Blanco; C Börner; A Villa; M Casado; Cecilio Giménez; R Pereira; E Bogonez
The role of pyruvate in neuronal calcium homeostasis. Effects on intracellular calcium pools.
The Journal of biological chemistry 1994;269(4):2468-76.
1994: J Gomeza; Cecilio Giménez; Francisco Zafra
Cellular distribution and regulation by cAMP of the GABA transporter (GAT-1) mRNA.
Brain research. Molecular brain research 1994;21(1-2):150-6.
1993: M Casado; Annie Bendahan; Francisco Zafra; Niels Christian Danbolt; Carmen Aragón; Cecilio Giménez; Baruch I Kanner
Phosphorylation and modulation of brain glutamate transporters by protein kinase C.
The Journal of biological chemistry 1993;268(36):27313-7.
1992: R Alcántara; M Casado; L Olivares; Cecilio Giménez; Carmen Aragón
L-glutamate transporter derived from mRNAs of primary glial cultures: expression in Xenopus laevis oocytes.
Brain research. Molecular brain research 1992;15(1-2):167-70.
1992: J Gomeza; Carmen Aragón; Cecilio Giménez
High-affinity transport of choline and amino acid neurotransmitters in synaptosomes from brain regions after lesioning the nucleus basalis magnocellularis of young and aged rats.
Neurochemical research 1992;17(4):345-50.
1991: M Casado; Francisco Zafra; Carmen Aragón; Cecilio Giménez
Activation of high-affinity uptake of glutamate by phorbol esters in primary glial cell cultures.
Journal of neurochemistry 1991;57(4):1185-90.
1989: M Casado; M C Aragón; Cecilio Giménez
Determination of monoamines in rat brain regions after chronic administration of lithium.
Neurochemical research 1989;14(9):905-8.
1989: Francisco Zafra; Cecilio Giménez
Characteristics and adaptive regulation of glycine transport in cultured glial cells.
The Biochemical journal 1989;258(2):403-8.
1989: Francisco Zafra; Cecilio Giménez
The role of chloride ions on the transport of glycine in plasma membrane vesicles from glial cells.
Biochimica et biophysica acta 1989;979(2):147-52.
1988: Francisco Zafra; Cecilio Giménez
Efflux and exchange of glycine by plasma membrane vesicles isolated from glioblastoma cells.
Biochimica et biophysica acta 1988;946(2):202-8.
1988: M C Aragón; Luis Agullo; Cecilio Giménez
Depolarization-induced release of glycine and beta-alanine from plasma membrane vesicles derived from rat brain synaptosomes.
Biochimica et biophysica acta 1988;941(2):209-16.
1988: Beatriz López-Corcuera; Cecilio Giménez; Carmen Aragón
Change of synaptic membrane lipid composition and fluidity by chronic administration of lithium.
Biochimica et biophysica acta 1988;939(3):467-75.
1987: Antonio Alcina; Francisco Zafra; Cecilio Giménez; Manuel Fresno
Stimulation of the trypanocidal and endoribonuclease activities by the interferon induced (2'-5') oligoadenylates.
Molecular and biochemical parasitology 1987;26(1-2):113-9.
1987: E Herrero; Cecilio Giménez; M C Aragón
Chronic administration of lithium modulates tryptophan transport by changing the properties of the synaptosomal plasma membrane.
Life sciences 1987;41(5):643-50.
1987: M C Aragón; Cecilio Giménez; Federico Mayor
Stoichiometry of sodium- and chloride-coupled glycine transport in synaptic plasma membrane vesicles derived from rat brain.
FEBS letters 1987;212(1):87-90.
1986: L Agullo; B Jimenez; Carmen Aragón; Cecilio Giménez
Beta-alanine transport in synaptic plasma membrane vesicles from rat brain. Efflux, exchange and stoichiometry.
European journal of biochemistry / FEBS 1986;159(3):611-7.
1986: F J Diez-Guerra; Federico Mayor; Cecilio Giménez
Tyrosine transport into isolated rat brain synaptosomes. Ionic dependence and kinetic studies.
Biochimica et biophysica acta 1986;857(2):209-16.
1986: M C Aragón; Cecilio Giménez
Efflux and exchange of glycine by synaptic plasma membrane vesicles derived from rat brain.
Biochimica et biophysica acta 1986;855(2):257-64.
1983: E Herrero; M C Aragón; Cecilio Giménez; Fernando Valdivieso
Tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes.
Journal of neurochemistry 1983;40(2):332-7.
1982: M C Aragón; Cecilio Giménez; Fernando Valdivieso
Inhibition by L-phenylalanine of tyrosine transport by synaptosomal plasma membrane vesicles: implications in the pathogenesis of phenylketonuria.
Journal of neurochemistry 1982;39(4):1185-7.
1982: Fernando Valdivieso; Cecilio Giménez; J Benavides; M C Aragón; F Mayor
[Pathogenesis of cerebral dysfunction in phenylketonuria].
Revista española de fisiología 1982;38 Suppl():189-93.
1982: F J Díez-Guerra; Cecilio Giménez; Fernando Valdivieso
[Inhibition of L-tyrosine transport in isolated synaptosomes from rat brain in the presence of L-tryptophan and L-phenylalanine].
Revista española de fisiología 1982;38 Suppl():217-20.
1981: J G Marvizón; Federico Mayor; M C Aragón; Cecilio Giménez; Fernando Valdivieso
L-Aspartate transport into plasma membrane vesicles derived from rat brain synaptosomes.
Journal of neurochemistry 1981;37(6):1401-6.
1981: M C Aragón; Cecilio Giménez; Federico Mayor; J G Marvizón; Fernando Valdivieso
Tyrosine transport by membrane vesicles isolated from rat brain.
Biochimica et biophysica acta 1981;646(3):465-70.
1981: J Díez-Guerra; M C Aragón; Cecilio Giménez; Fernando Valdivieso
Effect of thyroid hormones on the malic enzyme activity in rat brain during development.
Developmental neuroscience 1981;4(2):130-3.
1980: J Diez-Guerra; M C Aragón; Cecilio Giménez; Fernando Valdivieso
Effect of thyroid hormones on the 3-oxo acid CoA-transferase activity in rat brain during development.
Enzyme 1980;25(2):106-10.