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María-José Giménez

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Pneumococcal Infections

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Spain

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Asunción Fenoll; María-José Giménez; Juan José Granizo; Olga Robledo; María-Dolores Vicioso; Lorenzo Aguilar; Pilar Coronel
Comparative in vitro activity of common antibiotics and relationship with changes in Streptococcus pneumoniae serotypes causing otitis in children prior to and 10 years after introduction of conjugate vaccines in Spain.
Asunción Fenoll; María-José Giménez; Juan José Granizo; Olga Robledo; María-Dolores Vicioso; Lorenzo Aguilar; Pilar Coronel
Variations in serotypes and susceptibility of adult non-invasive Streptococcus pneumoniae isolates between the periods before (May 2000-May 2001) and 10 years after (May 2010-May 2011) introduction of conjugate vaccines for child immunisation in Spain.
José Barberán; Lorenzo Aguilar; María-José Giménez
Update on the clinical utility and optimal use of cefditoren.

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2012: Asunción Fenoll; María-José Giménez; Juan José Granizo; Olga Robledo; María-Dolores Vicioso; Lorenzo Aguilar; Pilar Coronel
Comparative in vitro activity of common antibiotics and relationship with changes in Streptococcus pneumoniae serotypes causing otitis in children prior to and 10 years after introduction of conjugate vaccines in Spain.
International journal of antimicrobial agents 2012;40(4):376-7.
2012: Asunción Fenoll; María-José Giménez; Juan José Granizo; Olga Robledo; María-Dolores Vicioso; Lorenzo Aguilar; Pilar Coronel
Variations in serotypes and susceptibility of adult non-invasive Streptococcus pneumoniae isolates between the periods before (May 2000-May 2001) and 10 years after (May 2010-May 2011) introduction of conjugate vaccines for child immunisation in Spain.
International journal of antimicrobial agents 2012;40(1):18-23.
2012: José Barberán; Lorenzo Aguilar; María-José Giménez
Update on the clinical utility and optimal use of cefditoren.
International journal of general medicine 2012;5():455-64.
2011: N González; Lorenzo Aguilar; David Sevillano; María-José Giménez; Luis Alou; Fabio Cafini; M Torrico; Ana-Maria López; Pilar Coronel; J Prieto
Efficacy of simulated cefditoren versus amoxicillin-clavulanate free concentrations in countering intrastrain ftsI gene diffusion in Haemophilus influenzae.
Antimicrobial agents and chemotherapy 2011;55(6):2788-94.
2011: M Torrico; Lorenzo Aguilar; David Sevillano; María-José Giménez; Luis Alou; N González; Fabio Cafini; Roy Cleeland; José Prieto
Activity of simulated serum concentrations of daptomycin versus vancomycin during the first 24h of treatment in the presence of physiological albumin concentrations against vancomycin-susceptible, -tolerant or -intermediate-resistant Staphylococcus aureus.
International journal of antimicrobial agents 2011;37(4):332-8.
2010: David Sevillano; Lorenzo Aguilar; Luis Alou; María-José Giménez; N González; M Torrico; Fabio Cafini; C Garcia-Rey; N Garcia-Escribano; José Prieto
Exposure-response analysis of tigecycline in pharmacodynamic simulations using different size inocula of target bacteria.
International journal of antimicrobial agents 2010;36(2):137-44.
2010: Fabio Cafini; Lorenzo Aguilar; Luis Alou; María-José Giménez; David Sevillano; M Torrico; N González; Pilar Coronel; José Prieto
Cefditoren versus ceftazidime in inducer-substrate combinations for the evaluation of AmpC production in a disc approximation test.
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2010;23(2):72-5.
2010: M Torrico; N González; María-José Giménez; Luis Alou; David Sevillano; D Navarro; M P Díaz-Antolín; N Larrosa; Lorenzo Aguilar; N Garcia-Escribano
Influence of media and testing methodology on susceptibility to tigecycline of Enterobacteriaceae with reported high tigecycline MIC.
Journal of clinical microbiology 2010;48(6):2243-6.
2010: Asunción Fenoll; Lorenzo Aguilar; María-José Giménez; María-Dolores Vicioso; Olga Robledo; Juan José Granizo; Pilar Coronel
Susceptibility of recently collected Spanish pneumococci nonsusceptible to oral penicillin from serotypes not included in the 7-valent conjugate vaccine.
Antimicrobial agents and chemotherapy 2010;54(6):2696-8.
2010: M Torrico; María-José Giménez; N González; Luis Alou; David Sevillano; Fabio Cafini; José Prieto; R Cleeland; Lorenzo Aguilar
Bactericidal activity of daptomycin versus vancomycin in the presence of human albumin against vancomycin-susceptible but tolerant methicillin-resistant Staphylococcus aureus (MRSA) with daptomycin minimum inhibitory concentrations of 1-2microg/mL.
International journal of antimicrobial agents 2010;35(2):131-7.
2010: Lorenzo Aguilar; María-José Giménez; José Barberán
Drug resistance in community-acquired respiratory tract infections: role for an emerging antibacterial.
Infection and drug resistance 2010;3():35-43.
2010: Fabio Cafini; Jose Yuste; María-José Giménez; David Sevillano; Lorenzo Aguilar; Luis Alou; Elisa Ramos-Sevillano; M Torrico; N González; Ernesto García; Pilar Coronel; J Prieto
Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model.
PloS one 2010;5(8):e12041.
2010: Luis Alou; María-José Giménez; F Manso; David Sevillano; Fabio Cafini; M Torrico; N González; José Prieto; J J Alió; Lorenzo Aguilar
In vitro killing activity of crevicular concentrations of tinidazole plus common oral antibiotics against high-density mixed inocula of periodontal pathogens in strict anaerobic conditions.
Journal of periodontology 2010;81(1):131-8.
2009: Lorenzo Aguilar; María-José Giménez; José Barberán
[Glycopeptide heteroresistance and tolerance in hospital grampositive isolates: "invisible" phenomena to the clinician with clinical implications?].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2009;22(4):173-9.
2009: Luis Alou; María-José Giménez; Fabio Cafini; Lorenzo Aguilar; David Sevillano; N González; M Torrico; José Prieto; César García-Rey; Nuria García-Escribano
In vitro effect of physiological concentrations of human albumin on the antibacterial activity of tigecycline.
The Journal of antimicrobial chemotherapy 2009;64(6):1230-3.
2009: Asunción Fenoll; María-José Giménez; María-Dolores Vicioso; Juan José Granizo; Olga Robledo; Lorenzo Aguilar
Susceptibility of pneumococci causing meningitis in Spain and prevalence among such isolates of serotypes contained in the 7-valent pneumococcal conjugate vaccine.
The Journal of antimicrobial chemotherapy 2009;64(6):1338-40.
2009: N González; Lorenzo Aguilar; Luis Alou; María-José Giménez; David Sevillano; M Torrico; Fabio Cafini; Pilar Coronel; Jose Prieto
Influence of different resistance traits on the competitive growth of Haemophilus influenzae in antibiotic-free medium and selection of resistant populations by different {beta}-lactams: an in vitro pharmacodynamic approach.
The Journal of antimicrobial chemotherapy 2009;63(6):1215-22.
2009: Luis Alou; María-José Giménez; F Manso; David Sevillano; M Torrico; N González; J J Granizo; Antonio Bascones; José Prieto; J R Maestre; Lorenzo Aguilar
Tinidazole inhibitory and cidal activity against anaerobic periodontal pathogens.
International journal of antimicrobial agents 2009;33(5):449-52.
2009: Asunción Fenoll; J J Granizo; Lorenzo Aguilar; María-José Giménez; L Aragoneses-Fenoll; G Hanquet; Julio Casal; David Tarragó
Temporal trends of invasive Streptococcus pneumoniae serotypes and antimicrobial resistance patterns in Spain from 1979 to 2007.
Journal of clinical microbiology 2009;47(4):1012-20.
2009: David Sevillano; María-José Giménez; Emilia Cercenado; Fabio Cafini; Amadeo Gené; Luis Alou; Francesc Marco; Luis Martínez-Martínez; Pilar Coronel; Lorenzo Aguilar
Genotypic versus phenotypic characterization, with respect to beta-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to beta-lactam resistance markers.
Antimicrobial agents and chemotherapy 2009;53(1):267-70.
2008: Asunción Fenoll; Lorenzo Aguilar; Juan José Granizo; María-José Giménez; L Aragoneses-Fenoll; C Mendez; David Tarragó
Has the licensing of respiratory quinolones for adults and the 7-valent pneumococcal conjugate vaccine (PCV-7) for children had herd effects with respect to antimicrobial non-susceptibility in invasive Streptococcus pneumoniae?
The Journal of antimicrobial chemotherapy 2008;62(6):1430-3.
2008: Francisco Soriano; Fabio Cafini; Lorenzo Aguilar; David Tarragó; Luis Alou; María-José Giménez; Matilde Gracia; Maria-Carmen Ponte; Denisa Leu; Marina Pana; Iwona Letowska; Asuncion Fenoll
Breakthrough in penicillin resistance? Streptococcus pneumoniae isolates with penicillin/cefotaxime MICs of 16 mg/L and their genotypic and geographical relatedness.
The Journal of antimicrobial chemotherapy 2008;62(6):1234-40.
2008: Asunción Fenoll; Lorenzo Aguilar; Olga Robledo; María-José Giménez; Juan José Granizo; Donald Biek; David Tarragó
In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime.
Antimicrobial agents and chemotherapy 2008;52(11):4209-10.
2008: Asunción Fenoll; Lorenzo Aguilar; Olga Robledo; María-José Giménez; Juan José Granizo; Donald Biek; David Tarragó
In vitro activity of ME1036 versus other beta-lactams against penicillin-resistant Streptococcus pneumoniae serotypes exhibiting higher amoxicillin than penicillin MIC.
The Journal of antimicrobial chemotherapy 2008;62(5):1156-8.
2008: Luis Alou; Lorenzo Aguilar; María-José Giménez; M Torrico; David Sevillano
Activity of serum concentrations of daptomycin vs. vancomycin against vancomycin-susceptible and resistant Enterococcus faecium in the presence of albumin physiological concentrations: an in vitro pharmacodynamic simulation.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2008;27(10):1009-11.
2008: José Barberán; Lorenzo Aguilar; María-José Giménez; Guillermo Carroquino; Juan-Jose Granizo; José Prieto
Levofloxacin plus rifampicin conservative treatment of 25 early staphylococcal infections of osteosynthetic devices for rigid internal fixation.
International journal of antimicrobial agents 2008;32(2):154-7.
2008: Fabio Cafini; Lorenzo Aguilar; Luis Alou; María-José Giménez; David Sevillano; M Torrico; N González; J J Granizo; J E Martín-Herrero; José Prieto
Cidal activity of oral third-generation cephalosporins against Streptococcus pneumoniae in relation to cefotaxime intrinsic activity.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2008;27(8):679-83.
2008: Asunción Fenoll; María-José Giménez; Olga Robledo; Lorenzo Aguilar; David Tarragó; Juan José Granizo; Mercedes Gimeno; Pilar Coronel
In vitro activity of oral cephalosporins against pediatric isolates of Streptococcus pneumoniae non-susceptible to penicillin, amoxicillin or erythromycin.
Journal of chemotherapy (Florence, Italy) 2008;20(2):175-9.
2008: Fabio Cafini; Lorenzo Aguilar; David Sevillano; María-José Giménez; Luis Alou; Asunción Fenoll; Olatz Echevarría; M Torrico; N González; Pilar Coronel; Jose Prieto
Decrease in bacterial load versus resistance selection of pneumococcal subpopulations by beta-lactam physiological concentrations over time: an in vitro pharmacodynamic simulation.
Microbial drug resistance (Larchmont, N.Y.) 2008;14(1):13-21.
2008: J García-de-Lomas; M Lerma; L Cebrián; E Esteban; María-José Giménez; Lorenzo Aguilar; V Domínguez; J J Randez
Evaluation of the in-vitro cidal activity and toxicity of a novel peroxygen biocide: 2-butanone peroxide.
The Journal of hospital infection 2008;68(3):248-54.
2008: David Sevillano; Lorenzo Aguilar; Luis Alou; María-José Giménez; M Torrico; N González; Fabio Cafini; María-Teresa Relaño; Pilar Coronel; José Prieto
Urine bactericidal activity against Escherichia coli isolates exhibiting different resistance phenotypes/genotypes in an in vitro pharmacodynamic model simulating urine concentrations obtained after oral administration of a 400-milligram single dose of cefditoren-pivoxil.
Antimicrobial agents and chemotherapy 2008;52(3):1184-6.
2008: David Sevillano; Lorenzo Aguilar; Luis Alou; María-José Giménez; N González; Martha Torrico; Fabio Cafini; Pilar Coronel; José Prieto
Beta-lactam effects on mixed cultures of common respiratory isolates as an approach to treatment effects on nasopharyngeal bacterial population dynamics.
PloS one 2008;3(12):e3846.
2008: David Sevillano; Lorenzo Aguilar; Luis Alou; María-José Giménez; N González; M Torrico; Fabio Cafini; Asunción Fenoll; Pilar Coronel; José Prieto
High protein binding and cidal activity against penicillin-resistant S. pneumoniae: a cefditoren in vitro pharmacodynamic simulation.
PloS one 2008;3(7):e2717.
2008: David Sevillano; Lorenzo Aguilar; Luis Alou; María-José Giménez; N González; Olatz Echeverría; M Torrico; L Valdes; Pilar Coronel; José Prieto
Beta-lactam activity against penicillin-resistant Streptococcus pneumoniae strains exhibiting higher amoxicillin versus penicillin minimum inhibitory concentration values: an in vitro pharmacodynamic simulation.
Chemotherapy 2008;54(2):84-90.
2008: Asunción Fenoll; María-José Giménez; Olga Robledo; Lorenzo Aguilar; David Tarragó; Juan José Granizo; J E Martín-Herrero
Influence of penicillin/amoxicillin non-susceptibility on the activity of third-generation cephalosporins against Streptococcus pneumoniae.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2008;27(1):75-80.
2007: María-José Giménez; José Barberán; Lorenzo Aguilar
[Therapeutic efficacy, animal models and experimental pharmacodynamics: what do we know about tigecycline?].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2007;20(4):387-94.
2007: Luis Alou; Lorenzo Aguilar; David Sevillano; María-José Giménez; N González; Olatz Echeverría; M Torrico; J E Martín; L Valdés; José Prieto
Levofloxacin vs. azithromycin pharmacodynamic activity against S. pneumoniae and H. influenzae with decreased susceptibility to amoxicillin/clavulanic acid.
Journal of chemotherapy (Florence, Italy) 2007;19(6):670-2.
2007: M Torrico; Lorenzo Aguilar; N González; María-José Giménez; Olatz Echeverría; Fabio Cafini; David Sevillano; Luis Alou; Pilar Coronel; José Prieto
influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhibiting an N526K mutation in the ftsI gene.
Antimicrobial agents and chemotherapy 2007;51(10):3699-706.
2007: Asunción Fenoll; Lorenzo Aguilar; Olga Robledo; María-José Giménez; David Tarragó; Juan José Granizo; Mercedes Gimeno; Pilar Coronel
Influence of the beta-lactam resistance phenotype on the cefuroxime versus cefditoren susceptibility of Streptococcus pneumoniae and Haemophilus influenzae recovered from children with acute otitis media.
The Journal of antimicrobial chemotherapy 2007;60(2):323-7.
2007: Juan García-de-Lomas; M Lerma; Laura Cebrián; J L Juan-Bañón; P Coronel; María-José Giménez; Lorenzo Aguilar
Influence of Haemophilus influenzae beta-lactamase production and/or ftsI gene mutations on in vitro activity of and susceptibility rates to aminopenicillins and second- and third-generation cephalosporins.
International journal of antimicrobial agents 2007;30(2):190-2.
2007: David Sevillano; María-José Giménez; Luis Alou; Lorenzo Aguilar; Fabio Cafini; M Torrico; N González; Olatz Echeverría; Pilar Coronel; José Prieto
Effects of human albumin and serum on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumoniae.
The Journal of antimicrobial chemotherapy 2007;60(1):156-8.
2007: Fabio Cafini; Lorenzo Aguilar; N González; María-José Giménez; M Torrico; Luis Alou; David Sevillano; P Vallejo; José Prieto
In vitro effect of the presence of human albumin or human serum on the bactericidal activity of daptomycin against strains with the main resistance phenotypes in Gram-positives.
The Journal of antimicrobial chemotherapy 2007;59(6):1185-9.
2007: David Tarragó; Lorenzo Aguilar; Wouter Jansen; María-José Giménez; Ana Avellón; Juan José Granizo; Julio Casal
Dependence of correlations between antibody titres and opsonophagocytosis on pneumococcal serotype and patient morbidity in pre- and post-pneumococcal vaccination states.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2007;13(4):369-76.
2007: Luis Alou; María-José Giménez; David Sevillano; Lorenzo Aguilar; N González; Olatz Echeverría; M Torrico; Pilar Coronel; José Prieto
Are beta-lactam breakpoints adequate to define non-susceptibility for all Haemophilus influenzae resistance phenotypes from a pharmacodynamic point of view?
The Journal of antimicrobial chemotherapy 2007;59(4):652-7.
2007: Lorenzo Aguilar; María-José Giménez
[Immunization and antimicrobials. Is there an association between the effects against Streptococcus pneumoniae?].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2007;20(1):125-7.
2007: J R Maestre; Antonio Bascones; P Sánchez; P Matesanz; Lorenzo Aguilar; María-José Giménez; I Pérez-Balcabao; J J Granizo; J Prieto
Odontogenic bacteria in periodontal disease and resistance patterns to common antibiotics used as treatment and prophylaxis in odontology in Spain.
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2007;20(1):61-7.
2007: Asunción Fenoll; María-José Giménez; Olga Robledo; Pilar Coronel; Mercedes Gimeno; Julio Casal; Lorenzo Aguilar
Activity of cefditoren against clinical isolates of Streptococcus pneumoniae showing non-susceptibility to penicillins, cephalosporins, macrolides, ketolides or quinolones.
International journal of antimicrobial agents 2007;29(2):224-6.
2006: Juan José Granizo; María-José Giménez; José Barberán; Pilar Coronel; Mercedes Gimeno; Lorenzo Aguilar
The efficacy of cefditoren pivoxil in the treatment of lower respiratory tract infections, with a focus on the per-pathogen bacteriologic response in infections caused by Streptococcus pneumoniae and Haemophilus influenzae: a pooled analysis of seven clinical trials.
Clinical therapeutics 2006;28(12):2061-9.
2006: Fabio Cafini; N González; M Torrico; Olatz Echeverría; David Sevillano; Luis Alou; María-José Giménez; Lorenzo Aguilar; María-Luisa Gómez-Lus
[Influence of the displacement of protein binding by ibuprofen in the activity of a third-generation cephalosporin against Streptococcus pneumoniae].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2006;19(4):332-6.
2006: José Barberán; Lorenzo Aguilar; Guillermo Carroquino; María-José Giménez; Beatriz Sánchez; David Martínez; José Prieto
Conservative treatment of staphylococcal prosthetic joint infections in elderly patients.
The American journal of medicine 2006;119(11):993.e7-10.
2006: David Sevillano; Lorenzo Aguilar; Luis Alou; María-José Giménez; Olatz Echevarría; Fabio Cafini; Eva Valero; Asunción Fenoll; José Prieto
Effects of antimicrobials on the competitive growth of Streptococcus pneumoniae: a pharmacodynamic in vitro model approach to selection of resistant populations.
The Journal of antimicrobial chemotherapy 2006;58(4):794-801.
2006: Luis Alou; María-José Giménez; David Sevillano; Lorenzo Aguilar; Fabio Cafini; Olatz Echeverría; Emilio Pérez-Trallero; José Prieto
A pharmacodynamic approach to antimicrobial activity in serum and epithelial lining fluid against in vivo-selected Streptococcus pneumoniae mutants and association with clinical failure in pneumonia.
The Journal of antimicrobial chemotherapy 2006;58(2):349-58.
2006: David Sevillano; Luis Alou; Lorenzo Aguilar; Olatz Echevarría; María-José Giménez; José Prieto
Azithromycin iv pharmacodynamic parameters predicting Streptococcus pneumoniae killing in epithelial lining fluid versus serum: an in vitro pharmacodynamic simulation.
The Journal of antimicrobial chemotherapy 2006;57(6):1128-33.
2006: Luis Alou; Lorenzo Aguilar; David Sevillano; María-José Giménez; Fabio Cafini; Eva Valero; María-Teresa Relaño; José Prieto
Urine bactericidal activity against resistant Escherichia coli in an in vitro pharmacodynamic model simulating urine concentrations obtained after 2000/125 mg sustained-release co-amoxiclav and 400 mg norfloxacin administration.
The Journal of antimicrobial chemotherapy 2006;57(4):714-9.
2006: Asunción Fenoll; Olga Robledo; M Lerma; María-José Giménez; Laura Cebrián; J Casal; Lorenzo Aguilar; M L Gómez-Lus
[Activity of cefpodoxime and other oral beta-lactams against Haemophilus influenzae and Streptococcus pneumoniae with different susceptibilities to penicillin].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2006;19(1):39-44.
2006: J J Granizo; María-José Giménez; Antonio Bascones; Laura K Aguilar
[Ecological impact of antibiotic treatment of dental infections].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2006;19(1):14-20.
2005: María-José Giménez; María-Luisa Gómez-Lus; L Valdés; Lorenzo Aguilar
[The role of the third-generation oral cephalosporin cefditoren pivoxil in the treatment of community-acquired infection in adults].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2005;18(3):210-6.
2005: María Mateo; Juan-Ramón Maestre; Lorenzo Aguilar; Fabio Cafini; Pilar Puente; Paloma Sánchez; Luis Alou; María-José Giménez; José Prieto
Genotypic versus phenotypic characterization, with respect to susceptibility and identification, of 17 clinical isolates of Staphylococcus lugdunensis.
The Journal of antimicrobial chemotherapy 2005;56(2):287-91.
2005: Carmen Ponte; Matilde Gracia; María-José Giménez; Lorenzo Aguilar; Carmen Martínez Maín; Yolanda Carpintero; Lorena Huelves; Antonio Carcas; Gema del Prado; Francisco Soriano
Urinary concentrations and bactericidal activity against amoxicillin-nonsusceptible strains of Escherichia coli with single-dose, oral, sustained-release amoxicillin/clavulanic acid: a phase I, open-label, noncomparative clinical trial in healthy volunteers.
Clinical therapeutics 2005;27(7):1043-9.
2005: David Tarragó; Noelia Lara; Asunción Fenoll; Julio Casal; María-José Giménez; Lorenzo Aguilar; David Sevillano
Specific antibodies, levofloxacin, and modulation of capsule-associated virulence in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy 2005;49(7):3095-6.
2005: P Matesanz; E Figuero; María-José Giménez; Lorenzo Aguilar; C Llor; José Prieto; Antonio Bascones
[From knowledge of bacterial etiology to the treatment and prevention of the most prevalent infections in the community: odontological infections].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2005;18(2):136-45.
2005: Lorenzo Aguilar; María-José Giménez; José Prieto
[Is prevention of reactivation of herpes simplex 1 virus necessary in cosmetic surgery and dermatological procedures?].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2005;18(2):118-23.
2005: Luis Alou; Lorenzo Aguilar; David Sevillano; María-José Giménez; Beatriz Laguna; Olatz Echeverría; Antonio Carcas; Rubin Lubomirov; Julio Casal; José Prieto
Effect of opsonophagocytosis mediated by specific antibodies on the co-amoxiclav serum bactericidal activity against Streptococcus pneumoniae after administration of a single oral dose of pharmacokinetically enhanced 2000/125 mg co-amoxiclav to healthy volunteers.
The Journal of antimicrobial chemotherapy 2005;55(5):742-7.
2005: Lorenzo Aguilar; María-José Giménez; J Casal; José Prieto
[Pharmacodynamics of beta-lactams and their modification by the immune system].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2005;18(1):80-2.
2005: David Sevillano; María-José Giménez; Lorenzo Aguilar; José Prieto
[Are pharmacodynamics a useful tool for the prevention of resistance?].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2005;18(1):77-9.
2005: Lorenzo Aguilar; María-José Giménez; J E Martín; José Prieto
[Pharmacodynamic optimization of ceftazidime against Pseudomonas aeruginosa: continuous infusion or intermittent administration?].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2005;18(1):21-5.
2005: Matilde Gracia; Carmina Martínez-Marín; Lorena Huelves; María-José Giménez; Lorenzo Aguilar; Antonio Carcas; Carmen Ponte; Francisco Soriano
Pulmonary damage and bacterial load in assessment of the efficacy of simulated human treatment-like amoxicillin (2,000 milligrams) therapy of experimental pneumococcal pneumonia caused by strains for which amoxicillin MICs differ.
Antimicrobial agents and chemotherapy 2005;49(3):996-1001.
2005: Luis Alou; Lorenzo Aguilar; David Sevillano; María-José Giménez; Olatz Echeverría; María-Luisa Gómez-Lus; José Prieto
Is there a pharmacodynamic need for the use of continuous versus intermittent infusion with ceftazidime against Pseudomonas aeruginosa? An in vitro pharmacodynamic model.
The Journal of antimicrobial chemotherapy 2005;55(2):209-13.
2004: José Barberán; María-José Giménez; Lorenzo Aguilar; José Prieto
[Scientific evidence and global conception of empirical treatment of lower respiratory tract infections in the community].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 2004;17(4):317-24.
2004: David Sevillano; Almudena Calvo; María-José Giménez; Luis Alou; Lorenzo Aguilar; Eva Valero; Antonio Carcas; José Prieto
Bactericidal activity of amoxicillin against non-susceptible Streptococcus pneumoniae in an in vitro pharmacodynamic model simulating the concentrations obtained with the 2000/125 mg sustained-release co-amoxiclav formulation.
The Journal of antimicrobial chemotherapy 2004;54(6):1148-51.
2004: David Tarragó; Lorenzo Aguilar; María-José Giménez; Asunción Fenoll; Julio Casal
Effects of amoxicillin subinhibitory concentrations on the cross-protection developed by pneumococcal antibodies in mouse sepsis caused by an amoxicillin-resistant serotype 6B Streptococcus pneumoniae strain.
Antimicrobial agents and chemotherapy 2004;48(11):4144-7.
2004: Raquel Amores; Luis Alou; María-José Giménez; David Sevillano; María-Luisa Gómez-Lus; Lorenzo Aguilar; José Prieto
In vitro combined effect of co-amoxiclav concentrations achievable in serum after a 2000/125 mg oral dose, and polymorphonuclear neutrophils against strains of Streptococcus pneumoniae exhibiting decreased susceptibility to amoxicillin.
International journal of antimicrobial agents 2004;24(1):79-82.
2004: Araceli Parra; Carmen Ponte; Carlos Cenjor; Marta García-Olmos; María-José Giménez; Lorenzo Aguilar; Francisco Soriano
In vivo activity of amoxicillin/clavulanic acid and erythromycin in experimental otitis media caused by Streptococcus pneumoniae plus Haemophilus influenzae.
International journal of antimicrobial agents 2004;23(1):25-31.
2003: Araceli Parra; Carmen Ponte; Carlos Cenjor; Marta García-Olmos; María-José Giménez; Lorenzo Aguilar; Francisco Soriano
Is it possible to achieve bacterial eradication in otitis media with effusion by empirical antibiotic high doses and concomitant administration of acetaminophen? A microbiological and pharmacological study in the gerbil model.
International journal of antimicrobial agents 2003;22(5):508-15.
2003: Marta García-Olmos; Araceli Parra; Gloria García-Calvo; Carmen Ponte; María-José Giménez; Lorenzo Aguilar; Francisco Soriano
Efficacy and pharmacodynamics of gemifloxacin versus levofloxacin in guinea pig pneumococcal pneumonia induced by strains with decreased ciprofloxacin susceptibility.
International journal of antimicrobial agents 2003;21(6):568-73.
2003: ML Gomez-Lus; María-José Giménez; Julio A Vázquez; Lorenzo Aguilar; L Anta; Sonsoles Berrón; Beatriz Laguna; José Prieto
Opsonophagocytosis versus complement bactericidal killing as effectors following Neisseria meningitidis group C vaccination.
Infection 2003;31(1):51-4.
2002: Julio Casal; María-José Giménez; Lorenzo Aguilar; JE Yuste; Isabel Jado; David Tarragó; Asunción Fenoll
Beta-lactam activity against resistant pneumococcal strains is enhanced by the immune system.
The Journal of antimicrobial chemotherapy 2002;50 Suppl S2():83-6.
2002: Gloria García-Calvo; Araceli Parra; Carmen Ponte; Francisco Soriano; María-José Giménez; Lorenzo Aguilar
Urine bactericidal activity after administration of gemifloxacin and trovafloxacin single doses in a phase I study.
International journal of antimicrobial agents 2002;20(6):477-80.
2002: JE Yuste; Asunción Fenoll; Julio Casal; María-José Giménez; Lorenzo Aguilar
Combined effect of specific antibodies (as serotherapy or preimmunization) and amoxicillin doses in treatment of Streptococcus pneumoniae sepsis in a mouse model.
Antimicrobial agents and chemotherapy 2002;46(12):4043-4.
2002: JE Yuste; Isabel Jado; María-José Giménez; Lorenzo Aguilar; F Molero; Asunción Fenoll; Julio Casal
Modification of bacteraemia by specific antibodies and relation with mortality in a pneumococcal mouse sepsis model.
Clinical and experimental immunology 2002;128(3):411-5.
2002: Julio Casal; Lorenzo Aguilar; Isabel Jado; JE Yuste; María-José Giménez; J Prieto; Asunción Fenoll
Effects of specific antibodies against Streptococcus pneumoniae on pharmacodynamic parameters of beta-lactams in a mouse sepsis model.
Antimicrobial agents and chemotherapy 2002;46(5):1340-4.
2002: M L Anta; María-José Giménez; Luis Alou; María-Luisa Gómez-Lus; Beatriz Laguna; Lorenzo Aguilar; José Prieto
Increase of in vitro amoxycillin bactericidal activity by clavulanic acid against Neisseria meningitis using time-kill curves.
International journal of antimicrobial agents 2002;19(3):249-50.
2002: Araceli Parra; Carmen Ponte; Carlos Cenjor; Gloria García-Calvo; María-José Giménez; Lorenzo Aguilar; Francisco Soriano
Optimal dose of amoxicillin in treatment of otitis media caused by a penicillin-resistant pneumococcus strain in the gerbil model.
Antimicrobial agents and chemotherapy 2002;46(3):859-62.
2002: JE Yuste; Isabel Jado; Asunción Fenoll; Lorenzo Aguilar; María-José Giménez; Julio Casal
Beta-lactam modification of the bacteraemic profile and its relationship with mortality in a pneumococcal mouse sepsis model.
The Journal of antimicrobial chemotherapy 2002;49(2):331-5.
2001: P Joyanes; A Pascual; María-José Giménez; I García; Lorenzo Aguilar; Evelio J Perea
Differences between two new quinolones (gemifloxacin and trovafloxacin) and ciprofloxacin in their concentration-dependent killing of Streptococcus pneumoniae.
Chemotherapy 2001;47(6):409-14.
2001: IP Balcabao; Luis Alou; Lorenzo Aguilar; ML Gomez-Lus; María-José Giménez; José Prieto
Influence of the decrease in ciprofloxacin susceptibility and the presence of human serum on the in vitro susceptibility of Streptococcus pneumoniae to five new quinolones.
The Journal of antimicrobial chemotherapy 2001;48(6):907-9.
2001: JE Yuste; María-José Giménez; Isabel Jado; Asunción Fenoll; Lorenzo Aguilar; Julio Casal
Enhanced decrease of blood colony counts by specific anti-pneumococcal antibodies in the presence of sub-inhibitory concentrations of amoxicillin.
The Journal of antimicrobial chemotherapy 2001;48(4):594-5.
2001: José Prieto; Lorenzo Aguilar; F Fuentes; María-José Giménez; Luis Alou; Rafael Dal-Ré; F Sörgel; Jesus Frías
Influence of diminished susceptibility of Streptococcus pneumoniae to ciprofloxacin on the serum bactericidal activity of gemifloxacin and trovafloxacin after a single dose in healthy volunteers.
International journal of antimicrobial agents 2001;18(3):231-8.
2001: Gloria García-Calvo; Araceli Parra; Lorenzo Aguilar; Carmen Ponte; María-José Giménez; Antonio Carcas; Martina Kinzig; Francisco Soriano
Antibacterial properties of gemifloxacin and trovafloxacin in urine ex vivo: phase I study.
Antimicrobial agents and chemotherapy 2001;45(6):1876-8.
2001: Julio A Vázquez; Sonsoles Berrón; María-José Giménez; Laura De La Fuente; Lorenzo Aguilar
In vitro susceptibility of Neisseria meningitidis isolates to gemifloxacin and ten other antimicrobial agents.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2001;20(2):150-1.
2001: G Garcia-Calvo; AS Molleja; María-José Giménez; Araceli Parra; E Nieto; Carmen Ponte; Lorenzo Aguilar; Francisco Soriano
Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers.
Antimicrobial agents and chemotherapy 2001;45(2):608-11.
2000: María-Luisa Gómez-Lus; Lorenzo Aguilar; J Vázquez; María-José Giménez; G Ruiz; Sonsoles Berrón; F Fuentes; José Prieto
Ex vivo bactericidal activity against group C Neisseria meningitidis in seronegative subjects.
Infection 2000;28(5):305-8.
2000: Sonsoles Berrón; Julio A Vázquez; María-José Giménez; Laura De La Fuente; Lorenzo Aguilar
In vitro susceptibilities of 400 Spanish isolates of Neisseria gonorrhoeae to gemifloxacin and 11 other antimicrobial agents.
Antimicrobial agents and chemotherapy 2000;44(9):2543-4.
2000: Asunción Fenoll; Julio Casal; María-José Giménez; Isabel Jado; Lorenzo Aguilar
Short-term bactericidal activity of amoxicillin and cefotaxime against penicillin-susceptible and -resistant pneumococcal strains: an in vitro pharmacodynamic simulation.
Journal of chemotherapy (Florence, Italy) 2000;12(2):124-8.
2000: F Fuentes; María-José Giménez; F Marco; Luis Alou; Lorenzo Aguilar; José Prieto
In vitro susceptibility to gemifloxacin and trovafloxacin of Streptococcus pneumoniae strains exhibiting decreased susceptibility to ciprofloxacin.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2000;19(2):137-9.
2000: Francisco Soriano; Araceli Parra; Carlos Cenjor; E Nieto; Gloria García-Calvo; María-José Giménez; Lorenzo Aguilar; Carmen Ponte
Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model.
The Journal of infectious diseases 2000;181(2):646-52.
1999: José Prieto; María-José Giménez; IP Balcabao; María-Luisa Gómez-Lus; Lorenzo Aguilar
Does the degree of penicillin susceptibility of Streptococcus pneumoniae affect the bactericidal activity of co-amoxiclav versus oral cephalosporins at physiological concentrations? An in vitro pharmacodynamic simulation.
Journal of chemotherapy (Florence, Italy) 1999;11(5):345-8.
1999: Carmen Ponte; Carlos Cenjor; Araceli Parra; E Nieto; Gloria García-Calvo; María-José Giménez; Lorenzo Aguilar; Francisco Soriano
Antimicrobial treatment of an experimental otitis media caused by a beta-lactamase positive isolate of Haemophilus influenzae.
The Journal of antimicrobial chemotherapy 1999;44(1):85-90.
1999: Lorenzo Aguilar; María-José Giménez
The use of efficacy animal models in breakpoint determination.
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 1999;12(2):149-51.
1999: María-Luisa Gómez-Lus; José Prieto; María-José Giménez; M García; L Anta; Lorenzo Aguilar
In vitro bactericidal activity of peak serum concentrations of co-amoxiclav, amoxicillin and vancomycin against methicillin-resistant Staphylococcus aureus.
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 1999;12(2):136-9.
1998: María-Luisa Gómez-Lus; Lorenzo Aguilar; María-José Giménez; José Prieto
[Inhibitors of beta-lactamases in Streptococcus pneumoniae].
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia 1998;11(4):382-3.
1998: José Prieto; Lorenzo Aguilar; María-José Giménez; D Toro; María-Luisa Gómez-Lus; Rafael Dal-Ré; IP Balcabao
In vitro activities of co-amoxiclav at concentrations achieved in human serum against the resistant subpopulation of heteroresistant Staphylococcus aureus: a controlled study with vancomycin.
Antimicrobial agents and chemotherapy 1998;42(7):1574-7.
1998: Carlos Cenjor; Carmen Ponte; Araceli Parra; E Nieto; Gloria García-Calvo; María-José Giménez; Lorenzo Aguilar; Francisco Soriano
In vivo efficacies of amoxicillin and cefuroxime against penicillin-resistant Streptococcus pneumoniae in a gerbil model of acute otitis media.
Antimicrobial agents and chemotherapy 1998;42(6):1361-4.
1998: María-Luisa Gómez-Lus; María-José Giménez; José Prieto; M Martín; Jesus Frías; Lorenzo Aguilar
Effect of polymorphonuclear neutrophils on serum bactericidal activity against Streptococcus pneumoniae after amoxicillin administration.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1998;17(1):40-3.
1997: M Martín; María-Luisa Gómez-Lus; Lorenzo Aguilar; P Martínez; María-José Giménez; José Prieto
Effect of clavulanic acid and/or polymorphonuclear neutrophils on amoxicillin bactericidal activity against Streptococcus pneumoniae.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1997;16(7):512-6.
1997: María-Luisa Gómez-Lus; L Aguilar; M Martín; María-José Giménez; P Martínez; J Prieto
Intracellular and extracellular killing of a penicillin-resistant, serotype-9 strain of Streptococcus pneumoniae by polymorphonuclear leucocytes in the presence of sub-inhibitory concentrations of clavulanic acid.
The Journal of antimicrobial chemotherapy 1997;40(1):142-4.
1997: Lorenzo Aguilar; J Rosendo; IP Balcabao; M Martín; María-José Giménez; J Frías; José Prieto
Pharmacodynamic effects of amoxicillin versus cefotaxime against penicillin-susceptible and penicillin-resistant pneumococcal strains: a phase I study.
Antimicrobial agents and chemotherapy 1997;41(6):1389-91.
1997: Lorenzo Aguilar; María-José Giménez; J Costa; Rafael Dal-Ré; José Prieto
Suspicion of quinolone active metabolite following discrepancy between predicted and experimental urine bactericidal activities.
Antimicrobial agents and chemotherapy 1997;41(5):927-30.