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Mercedes Giralt

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Mercedes Giralt; Iain L Campbell; Marco Castro-Freire; Gemma Comes; Maria Erta; Beatriz Ferrer; Agustina García; Paula Pifarré; Albert Quintana; Raquel Ramos; Elisenda Sanz; Mercedes Unzeta; Juan Hidalgo
Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6.
Albert Quintana; Gemma Comes; Maria Erta; Beatriz Ferrer; Mercedes Giralt; Juan Hidalgo
Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior.
Paula Pifarré; Judith Prado; Mercedes Giralt; Amalia Molinero; Juan Hidalgo; Agustina Garcia
Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury.

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All Publications

2013: Mercedes Giralt; Iain L Campbell; Marco Castro-Freire; Gemma Comes; Maria Erta; Beatriz Ferrer; Agustina García; Paula Pifarré; Albert Quintana; Raquel Ramos; Elisenda Sanz; Mercedes Unzeta; Juan Hidalgo
Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6.
Glia 2013;61(4):587-600.
2013: Albert Quintana; Gemma Comes; Maria Erta; Beatriz Ferrer; Mercedes Giralt; Juan Hidalgo
Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior.
Brain, behavior, and immunity 2013;27(1):162-73.
2010: Paula Pifarré; Judith Prado; Mercedes Giralt; Amalia Molinero; Juan Hidalgo; Agustina Garcia
Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury.
Journal of neurochemistry 2010;112(3):807-17.
2010: Juan Hidalgo; Sergi Florit; Mercedes Giralt; Beatriz Ferrer; Charlotte Keller; Henriette Pilegaard
Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat.
Brain, behavior, and immunity 2010;24(1):119-26.
2007: Albert Quintana; Amalia Molinero; Sergi Florit; Yasmina Manso; Gemma Comes; Javier Carrasco; Mercedes Giralt; Rehannah Borup; Omid Niazi; Iain L Campbell; Milena Penkowa; Juan Hidalgo
Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior.
Journal of neuroscience research 2007;85(12):2668-85.
2007: Albert Quintana; Mercedes Giralt; Amalia Molinero; Iain L Campbell; Milena Penkowa; Juan Hidalgo
Analysis of the cerebral transcriptome in mice subjected to traumatic brain injury: importance of IL-6.
Neuroimmunomodulation 2007;14(3-4):139-43.
2006: Milena Penkowa; Mario Cáceres; Rehannah Borup; Omid Niazi; Christian Bjørn Poulsen; Albert Quintana; Amalia Molinero; Javier Carrasco; Sergi Florit; Mercedes Giralt; Juan Hidalgo
Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: insights from global gene expression profiling in wild-type and MT-I + II knockout mice.
Journal of neuroscience research 2006;84(7):1452-74.
2006: Juan Hidalgo; Milena Penkowa; Carmen Espejo; Eva M Martínez-Cáceres; Javier Carrasco; Albert Quintana; Amalia Molinero; Sergi Florit; Mercedes Giralt; Arantxa Ortega-Aznar
Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation.
Experimental biology and medicine (Maywood, N.J.) 2006;231(9):1450-8.
2006: Milena Penkowa; Laura Tio; Mercedes Giralt; Albert Quintana; Amalia Molinero; Sílvia Atrian; Milan Vasák; Juan Hidalgo
Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury.
Journal of neuroscience research 2006;83(6):974-84.
2005: Albert Quintana; Mercedes Giralt; Santiago Rojas; Milena Penkowa; Iain L Campbell; Juan Hidalgo; Amalia Molinero
Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury.
Journal of neuroscience research 2005;82(5):701-16.
2005: Milena Penkowa; Pernille Keller; Charlotte Keller; Juan Hidalgo; Mercedes Giralt; Bente Klarlund Pedersen
Exercise-induced metallothionein expression in human skeletal muscle fibres.
Experimental physiology 2005;90(4):477-86.
2005: Milena Penkowa; Sergi Florit; Mercedes Giralt; Albert Quintana; Amalia Molinero; Javier Carrasco; Juan Hidalgo
Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures.
Journal of neuroscience research 2005;79(4):522-34.
2005: Christian Bjørn Poulsen; Milena Penkowa; Rehannah Borup; Omid Niazi; Mario Cáceres; Albert Quintana; Amalia Molinero; Javier Carrasco; Mercedes Giralt; Juan Hidalgo
Brain response to traumatic brain injury in wild-type and interleukin-6 knockout mice: a microarray analysis.
Journal of neurochemistry 2005;92(2):417-32.
2004: Milena Penkowa; Albert Quintana; Javier Carrasco; Mercedes Giralt; Amalia Molinero; Juan Hidalgo
Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide.
Journal of neuroscience research 2004;77(1):35-53.
2003: Milena Penkowa; Jordi Camats; Hanne Hadberg; Albert Quintana; Santiago Rojas; Mercedes Giralt; Amalia Molinero; Iain L Campbell; Juan Hidalgo
Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide.
Journal of neuroscience research 2003;73(4):481-96.
2003: Milena Penkowa; Mercedes Giralt; Natalia Lago; Jordi Camats; Javier Carrasco; Joaquin Hernández; Amalia Molinero; Iain L Campbell; Juan Hidalgo
Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury.
Experimental neurology 2003;181(2):130-48.
2003: Javier Carrasco; Milena Penkowa; Mercedes Giralt; Jordi Camats; Amalia Molinero; Iain L Campbell; Richard D Palmiter; Juan Hidalgo
Role of metallothionein-III following central nervous system damage.
Neurobiology of disease 2003;13(1):22-36.
2003: Milena Penkowa; Jordi Camats; Mercedes Giralt; Amalia Molinero; Joaquín Hernández; Javier Carrasco; Iain L Campbell; Juan Hidalgo
Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression.
Glia 2003;42(3):287-306.
2003: Amalia Molinero; Milena Penkowa; Joaquín Hernández; Jordi Camats; Mercedes Giralt; Natalia Lago; Javier Carrasco; Iain L Campbell; Juan Hidalgo
Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6.
Journal of neuropathology and experimental neurology 2003;62(3):315-28.
2002: Mercedes Giralt; Milena Penkowa; Joaquín Hernández; Amalia Molinero; Javier Carrasco; Natalia Lago; Jordi Camats; Iain L Campbell; Juan Hidalgo
Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6.
Neurobiology of disease 2002;9(3):319-38.
2002: Milena Penkowa; Mercedes Giralt; Jordi Camats; Juan Hidalgo
Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide.
The Journal of comparative neurology 2002;444(2):174-89.
2002: Juan Hidalgo; Milena Penkowa; Mercedes Giralt; Javier Carrasco; Amalia Molinero
Metallothionein expression and oxidative stress in the brain.
Methods in enzymology 2002;348():238-49.
2002: Mercedes Giralt; Milena Penkowa; Natalia Lago; Amalia Molinero; Juan Hidalgo
Metallothionein-1+2 protect the CNS after a focal brain injury.
Experimental neurology 2002;173(1):114-28.
2001: Milena Penkowa; Mercedes Giralt; P S Thomsen; Javier Carrasco; Juan Hidalgo
Zinc or copper deficiency-induced impaired inflammatory response to brain trauma may be caused by the concomitant metallothionein changes.
Journal of neurotrauma 2001;18(4):447-63.
2000: Milena Penkowa; Mercedes Giralt; Javier Carrasco; Hanne Hadberg; Juan Hidalgo
Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice.
Glia 2000;32(3):271-85.
2000: Milena Penkowa; Javier Carrasco; Mercedes Giralt; Amalia Molinero; Joaquín Hernández; Iain L Campbell; Juan Hidalgo
Altered central nervous system cytokine-growth factor expression profiles and angiogenesis in metallothionein-I+II deficient mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(8):1174-89.
2000: J Hernández; Javier Carrasco; E Belloso; Mercedes Giralt; H Bluethmann; D Kee Lee; Glen K Andrews; Juan Hidalgo
Metallothionein induction by restraint stress: role of glucocorticoids and IL-6.
Cytokine 2000;12(6):791-6.
2000: Javier Carrasco; Mercedes Giralt; Milena Penkowa; A K Stalder; I L Campbell; Juan Hidalgo
Metallothioneins are upregulated in symptomatic mice with astrocyte-targeted expression of tumor necrosis factor-alpha.
Experimental neurology 2000;163(1):46-54.
2000: Mercedes Giralt; Amalia Molinero; Javier Carrasco; Juan Hidalgo
Effect of dietary zinc deficiency on brain metallothionein-I and -III mRNA levels during stress and inflammation.
Neurochemistry international 2000;36(6):555-62.
1999: Javier Carrasco; Mercedes Giralt; Amalia Molinero; Milena Penkowa; Torben Moos; Juan Hidalgo
Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains.
Journal of neurotrauma 1999;16(11):1115-29.
1999: Milena Penkowa; Javier Carrasco; Mercedes Giralt; Torben Moos; Juan Hidalgo
CNS wound healing is severely depressed in metallothionein I- and II-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(7):2535-45.
1999: Milena Penkowa; Mercedes Giralt; Torben Moos; P S Thomsen; J Hernández; Juan Hidalgo
Impaired inflammatory response to glial cell death in genetically metallothionein-I- and -II-deficient mice.
Experimental neurology 1999;156(1):149-64.