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Jean-Pierre Girault

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J Pons; V Tanchou; Jean-Pierre Girault; Gildas Bertho; Nathalie Evrard-Todeschi
NMR applications for identifying β-TrCP protein-ligand interactions.
Guillaume Bouvier; Nathalie Evrard-Todeschi; Jean-Pierre Girault; Gildas Bertho
Automatic clustering of docking poses in virtual screening process using self-organizing map.
Gildas Bertho; Guillaume Bouvier; Gaston Hui Bon Hoa; Jean-Pierre Girault
The key-role of tyrosine 155 in the mechanism of prion transconformation as highlighted by a study of sheep mutant peptides.

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All Publications

2011: J Pons; V Tanchou; Jean-Pierre Girault; Gildas Bertho; Nathalie Evrard-Todeschi
NMR applications for identifying β-TrCP protein-ligand interactions.
Mini reviews in medicinal chemistry 2011;11(4):283-97.
2010: Guillaume Bouvier; Nathalie Evrard-Todeschi; Jean-Pierre Girault; Gildas Bertho
Automatic clustering of docking poses in virtual screening process using self-organizing map.
Bioinformatics (Oxford, England) 2010;26(1):53-60.
2008: Gildas Bertho; Guillaume Bouvier; Gaston Hui Bon Hoa; Jean-Pierre Girault
The key-role of tyrosine 155 in the mechanism of prion transconformation as highlighted by a study of sheep mutant peptides.
Peptides 2008;29(7):1073-84.
2008: Julien Pons; Nathalie Evrard-Todeschi; Gildas Bertho; Josyane Gharbi-Benarous; Valérie Tanchou; Richard Benarous; Jean-Pierre Girault
Transfer-NMR and docking studies identify the binding of the peptide derived from activating transcription factor 4 to protein ubiquitin ligase beta-TrCP. Competition STD-NMR with beta-catenin.
Biochemistry 2008;47(1):14-29.
2007: Julien Pons; Nathalie Evrard-Todeschi; Gildas Bertho; Josyane Gharbi-Benarous; Richard Benarous; Jean-Pierre Girault
Phosphorylation-dependent structure of ATF4 peptides derived from a human ATF4 protein, a member of the family of transcription factors.
Peptides 2007;28(12):2253-67.
2007: Eva Snogan; Isabelle Vahirua-Lechat; Raimana Ho; Gildas Bertho; Jean-Pierre Girault; Sophie Ortiga; Annick Maria; René Lafont
Ecdysteroids from the medicinal fern Microsorum scolopendria (Burm. f.).
Phytochemical analysis : PCA 2007;18(5):441-50.
2007: Julien Pons; Nathalie Evrard-Todeschi; Gildas Bertho; Josyane Gharbi-Benarous; Vanessa Sonois; Richard Benarous; Jean-Pierre Girault
Structural studies on 24P-IkappaBalpha peptide derived from a human IkappaB-alpha protein related to the inhibition of the activity of the transcription factor NF-kappaB.
Biochemistry 2007;46(11):2958-72.
2006: Simon Megy; Gildas Bertho; Josyane Gharbi-Benarous; Françoise Baleux; Richard Benarous; Jean-Pierre Girault
STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody.
FEBS letters 2006;580(22):5411-22.
2006: Nathalie Evrard-Todeschi; Josyane Gharbi-Benarous; Gildas Bertho; Gael COADOU; Simon Megy; Richard Benarous; Jean-Pierre Girault
NMR studies for identifying phosphopeptide ligands of the HIV-1 protein Vpu binding to the F-box protein beta-TrCP.
Peptides 2006;27(1):194-210.
2005: Simon Megy; Gildas Bertho; Josyane Gharbi-Benarous; Nathalie Evrard-Todeschi; Gael COADOU; Emmanuel Ségéral; Catherine Iehle; Eric Quemeneur; Richard Benarous; Jean-Pierre Girault
STD and TRNOESY NMR studies on the conformation of the oncogenic protein beta-catenin containing the phosphorylated motif DpSGXXpS bound to the beta-TrCP protein.
The Journal of biological chemistry 2005;280(32):29107-16.
2005: Annick Maria; Jean-Pierre Girault; Ziyadilla Saatov; Juraj Harmatha; Laurence Dinan; René Lafont
Ecdysteroid glycosides: identification, chromatographic properties, and biological significance.
Journal of chromatographic science 2005;43(3):149-57.
2005: Simon Megy; Gildas Bertho; Josyane Gharbi-Benarous; Françoise Baleux; Richard Benarous; Jean-Pierre Girault
Solution structure of a peptide derived from the oncogenic protein beta-Catenin in its phosphorylated and nonphosphorylated states.
Peptides 2005;26(2):227-41.
2004: Simon Megy; Gildas Bertho; Sergey Kozin; Pascale Debey; Gaston Hui Bon Hoa; Jean-Pierre Girault
Possible role of region 152-156 in the structural duality of a peptide fragment from sheep prion protein.
Protein science : a publication of the Protein Society 2004;13(12):3151-60.
2004: Josyane Gharbi-Benarous; Gildas Bertho; Nathalie Evrard-Todeschi; Gael COADOU; Simon Megy; Thierry Delaunay; Richard Benarous; Jean-Pierre Girault
Epitope mapping of the phosphorylation motif of the HIV-1 protein Vpu bound to the selective monoclonal antibody using TRNOESY and STD NMR spectroscopy.
Biochemistry 2004;43(46):14555-65.
2003: Gael COADOU; Josyane Gharbi-Benarous; Simon Megy; Gildas Bertho; Nathalie Evrard-Todeschi; Emmanuel Segeral; Richard Benarous; Jean-Pierre Girault
NMR studies of the phosphorylation motif of the HIV-1 protein Vpu bound to the F-box protein beta-TrCP.
Biochemistry 2003;42(50):14741-51.
2002: Laurent Verdier; Josyane Gharbi-Benarous; Gildas Bertho; Pascale Mauvais; Jean-Pierre Girault
Antibiotic resistance peptides: interaction of peptides conferring macrolide and ketolide resistance with Staphylococcus aureus ribosomes: conformation of bound peptides as determined by transferred NOE experiments.
Biochemistry 2002;41(13):4218-29.
2002: Gael COADOU; Nathalie Evrard-Todeschi; Josyane Gharbi-Benarous; Richard Benarous; Jean-Pierre Girault
HIV-1 encoded virus protein U (Vpu) solution structure of the 41-62 hydrophilic region containing the phosphorylated sites Ser52 and Ser56.
International journal of biological macromolecules 2002;30(1):23-40.
2002: Pauline C Bourne; Pensri Whiting; Tarlochan S Dhadialla; Robert E Hormann; Jean-Pierre Girault; Juraj Harmatha; René Lafont; Laurence Dinan
Ecdysteroid 7,9(11)-dien-6-ones as potential photoaffinity labels for ecdysteroid binding proteins.
Journal of insect science (Online) 2002;2():11.
2001: Sergey Kozin; Gildas Bertho; Alexey K Mazur; H Rabesona; Jean-Pierre Girault; Thomas Haertlé; M Takahashi; Pascale Debey; Gaston Hui Bon Hoa
Sheep prion protein synthetic peptide spanning helix 1 and beta-strand 2 (residues 142-166) shows beta-hairpin structure in solution.
The Journal of biological chemistry 2001;276(49):46364-70.
2001: Y Meng; Pensri Whiting; L Zibareva; Gildas Bertho; Jean-Pierre Girault; René Lafont; Laurence Dinan
Identification and quantitative analysis of the phytoecdysteroids in Silene species (Caryophyllaceae) by high-performance liquid chromatography. Novel ecdysteroids from S. pseudotites.
Journal of chromatography. A 2001;935(1-2):309-19.
2001: Mária Báthori; René Lafont; Jean-Pierre Girault; Imre Máthé
[Structural diversity of ecdysteroids of Lychnis flos-cuculi].
Acta pharmaceutica Hungarica 2001;71(2):157-67.
2001: Françoise Auchère; Gildas Bertho; Isabelle Artaud; Jean-Pierre Girault; Chantal Capeillère-Blandin
Purification and structure of the major product obtained by reaction of NADPH and NMNH with the myeloperoxidase/hydrogen peroxide/chloride system.
European journal of biochemistry / FEBS 2001;268(10):2889-95.
2000: Mária Báthori; Jean-Pierre Girault; Imre Máthé; René Lafont
Isolation of 5 alpha- and 5 beta-dihydrorubrosterone from Silene otites L. (Wib).
Biomedical chromatography : BMC 2000;14(7):464-7.
2000: Nathalie Evrard-Todeschi; Josyane Gharbi-Benarous; C Gaillet; Laurent Verdier; Gildas Bertho; C Lang; A Parent; Jean-Pierre Girault
Conformations in solution and bound to bacterial ribosomes of ketolides, HMR 3647 (telithromycin) and RU 72366: a new class of highly potent antibacterials.
Bioorganic & medicinal chemistry 2000;8(7):1579-97.
2000: Z T Sadikov; Ziyadilla Saatov; Jean-Pierre Girault; René Lafont
Sileneoside H, a new phytoecdysteroid from Silene brahuica.
Journal of natural products 2000;63(7):987-8.
2000: Laurent Verdier; Gildas Bertho; Josyane Gharbi-Benarous; Jean-Pierre Girault
Lincomycin and clindamycin conformations. A fragment shared by macrolides, ketolides and lincosamides determined from TRNOE ribosome-bound conformations.
Bioorganic & medicinal chemistry 2000;8(6):1225-43.
1998: Gildas Bertho; Josyane Gharbi-Benarous; Marcel Delaforge; C Lang; A Parent; Jean-Pierre Girault
Conformational analysis of ketolide, conformations of RU 004 in solution and bound to bacterial ribosomes.
Journal of medicinal chemistry 1998;41(18):3373-86.
1998: Nathalie Evrard-Todeschi; Josyane Gharbi-Benarous; V Larue; Jean-Pierre Girault
Predictive study by molecular modeling to promote specific probes of glutamate receptors, using methylated cyclic glutamic acid derivatives (trans- and cis-ACPD). Comparison with specific agonists.
Journal of chemical information and computer sciences 1998;38(4):742-60.
1998: Gildas Bertho; P Ladam; Josyane Gharbi-Benarous; Marcel Delaforge; Jean-Pierre Girault
Solution conformation of methylated macrolide antibiotics roxithromycin and erythromycin using NMR and molecular modelling. Ribosome-bound conformation determined by TRNOE and formation of cytochrome P450-metabolite complex.
International journal of biological macromolecules 1998;22(2):103-27.
1998: Gildas Bertho; Josyane Gharbi-Benarous; Marcel Delaforge; Jean-Pierre Girault
Transferred nuclear Overhauser effect study of macrolide-ribosome interactions: correlation between antibiotic activities and bound conformations.
Bioorganic & medicinal chemistry 1998;6(2):209-21.
1997: Laurence Dinan; Pensri Whiting; Jean-Pierre Girault; René Lafont; Tarlochan S Dhadialla; D E Cress; Bruno Mugat; Christophe Antoniewski; JEAN-ANTOINE LEPESANT
Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor.
The Biochemical journal 1997;327 ( Pt 3)():643-50.
1997: Mária Báthori; Jean-Pierre Girault; Huba Kalász; Imre Máthé; René Lafont
New minor ecdysteroids from Silene otites (L.) Wib.
Journal of pharmaceutical and biomedical analysis 1997;16(2):327-36.
1997: N Todeschi; Josyane Gharbi-Benarous; Jean-Pierre Girault
Structure of kainic acid totally elucidated by NMR and molecular modelling.
Bioorganic & medicinal chemistry 1997;5(10):1943-57.
1997: U A Baltayev; Laurence Dinan; Jean-Pierre Girault; René Lafont
24(24(1))[Z]-dehydroamarasterone B, a phytoecdysteroid from seeds of Leuzea carthamoides.
Phytochemistry 1997;46(1):103-5.
1997: V Larue; Josyane Gharbi-Benarous; Francine Acher; Aroulmoji Vincent; Carine Tisné; N Todeschi; Robert Azerad; Jean-Pierre Girault
Solution conformation of alpha, beta or gamma-methylglutamyl-containing derivatives as probes of vitamin K-dependent carboxylase using molecular modelling and nuclear magnetic resonance.
International journal of biological macromolecules 1997;20(2):131-59.
1997: N Todeschi; Josyane Gharbi-Benarous; Francine Acher; V Larue; Jean-Philippe Pin; J Bockaert; Robert Azerad; Jean-Pierre Girault
Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists.
Bioorganic & medicinal chemistry 1997;5(2):335-52.
1997: V Larue; Josyane Gharbi-Benarous; Francine Acher; Robert Azerad; Jean-Pierre Girault
Vitamin K-dependent carboxylase. In vitro inhibitory activity of cyclopentane and cyclohexane-derived analogues of glutamic acid and their conformational study by NMR and molecular dynamics in aqueous solution.
The journal of peptide research : official journal of the American Peptide Society 1997;49(1):28-45.
1996: C Blais; Chantal Dauphin-Villemant; N Kovganko; Jean-Pierre Girault; C Descoins; R Lafont
Evidence for the involvement of 3-oxo-delta 4 intermediates in ecdysteroid biosynthesis.
The Biochemical journal 1996;320 ( Pt 2)():413-9.
1996: P Valadon; Patrick M Dansette; Jean-Pierre Girault; C Amar; Daniel Mansuy
Thiophene sulfoxides as reactive metabolites: formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo.
Chemical research in toxicology 1996;9(8):1403-13.
1996: V Larue; Josyane Gharbi-Benarous; F Archer; Robert Azerad; Jean-Pierre Girault
Conformational study in water by NMR and molecular modeling of cyclic glutamic acid analogues as probes of vitamin K dependent carboxylase.
Journal of chemical information and computer sciences 1996;36(4):717-25.
1995: P Ladam; Josyane Gharbi-Benarous; Marcel Delaforge; M R van Calsteren; C K Jankowski; Jean-Pierre Girault
Conformational change due to esterification of hydroxy groups in erythromycin A and its major metabolite: analysis of these derivatives with different biological properties using NMR and molecular dynamics (MD) data.
Bioorganic & medicinal chemistry 1995;3(5):587-604.
1995: J Pis; Jean-Pierre Girault; M Larchevêque; Chantal Dauphin-Villemant; R Lafont
A convenient synthesis of 25-deoxyecdysone, a major secretory product of crustacean Y-organs and of 2,25-dideoxyecdysone, its putative immediate precursor.
Steroids 1995;60(2):188-94.
1992: Marcel Delaforge; P Ladam; G Bouillé; J G Benarous; Maryse Jaouen; Jean-Pierre Girault
pH effects on the N-demethylation and formation of the cytochrome P-450 iron II nitrosoalkane complex for erythromycin derivatives.
Chemico-biological interactions 1992;85(2-3):215-27.
1992: M H Fouchet; C Gauthier; Eric Guittet; Jean-Pierre Girault; J Igolen; Jean-Claude Chottard
Synthesis and characterization of a d(ApG) platinated nonanucleotide duplex.
Biochemical and biophysical research communications 1992;182(2):555-60.
1991: Josyane Gharbi-Benarous; Marcel Delaforge; C K Jankowski; Jean-Pierre Girault
A comparative NMR study between the macrolide antibiotic roxithromycin and erythromycin A with different biological properties.
Journal of medicinal chemistry 1991;34(3):1117-25.
1990: F Herman; Jirí Kozelka; Véronique Stoven; Eric Guittet; Jean-Pierre Girault; Tam Huynh-Dinh; J Igolen; Jean-Yves Lallemand; Jean-Claude Chottard
A d(GpG)-platinated decanucleotide duplex is kinked. An extended NMR and molecular mechanics study.
European journal of biochemistry / FEBS 1990;194(1):119-33.
1989: F J Dijt; Jean-Claude Chottard; Jean-Pierre Girault; Jan Reedijk
Formation and structure of reaction products of cis-PtCl2(NH3)2 with d(ApG) and/or d(GpA) in di-, tri- and penta-nucleotides. Preference for GpA chelation over ApG chelation.
European journal of biochemistry / FEBS 1989;179(2):335-44.
1988: Jean-Pierre Girault; R Lafont; U Kerb
Ecdysone catabolism in the white mouse.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(5):716-20.
1988: R Lafont; Jean-Pierre Girault; U Kerb
Excretion and metabolism of injected ecdysone in the white mouse.
Biochemical pharmacology 1988;37(6):1174-7.
1986: B van Hemelryck; Eric Guittet; G Chottard; Jean-Pierre Girault; F Herman; Tam Huynh-Dinh; Jean-Yves Lallemand; J Igolen; Jean-Claude Chottard
A high melting cis-[Pt(NH3)2[d(GpG)]]adduct of a decanucleotide duplex.
Biochemical and biophysical research communications 1986;138(2):758-63.
1984: E Segal; Jean-Pierre Girault; G Muzard; G Chottard; Jean-Claude Chottard; B le Pecq
Structure determination of the adduct formed between the signal nucleotide diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) and cis-[Pt(NH3)2Cl2].
Biopolymers 1984;23(9):1623-35.
1984: Jean-Michel Neumann; S Tran-Dinh; Jean-Pierre Girault; Jean-Claude Chottard; Tam Huynh-Dinh; J Igolen
DNA fragment conformations. A 1H-NMR conformational analysis of the d(G-G)-chelated platinum-oligonucleotide d(A-T-G-G)cisPt.
European journal of biochemistry / FEBS 1984;141(3):465-72.
1982: Jean-Pierre Girault; Jean-Claude Chottard; Eric Guittet; Jean-Yves Lallemand; Tam Huynh-Dinh; J Igolen
Specific platinum chelation by the guanines of the deoxyhexanucleotide d(T-G-G-C-C-A) upon reaction with cis-[Pt(NH3)2(H2O)2](NO3)2.
Biochemical and biophysical research communications 1982;109(4):1157-63.
1982: J H den Hartog; Cornelis Altona; Jean-Claude Chottard; Jean-Pierre Girault; Jean-Yves Lallemand; F A de Leeuw; A T Marcelis; Jan Reedijk
Conformational analysis of the adduct cis-[Pt(NH3)2 d(GpG)]+ in aqueous solution. A high field (500-300 MHz) nuclear magnetic resonance investigation.
Nucleic acids research 1982;10(15):4715-30.
1982: Jean-Pierre Girault; G Chottard; Jean-Yves Lallemand; Jean-Claude Chottard
Interaction of cis-[Pt(NH3)2(H2O)2](NO3)2 with ribose deoxyribose diguanosine phosphates.
Biochemistry 1982;21(6):1352-6.