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Ada Girnita

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Jan Lapins; Bernt Lindelöf; Anders Ljung; Lennart Emtestam; Ada Girnita; Mari-Anne Hedblad; Johan Hansson
[Synchronous multiple primary melanoma are often missed. Increased attention to the patient's entire skin is required for early diagnosis].
Huiyuan Zheng; Ada Girnita; Iulian Oprea; Hongchang Shen; Radu Stefanescu; Claire Worrall; Leonard Girnita
β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.
Huiyuan Zheng; Ada Girnita; Tarik Issad; Stefan Seregard; Hongchang Shen; Claire Worrall; Leonard Girnita
Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.

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All Publications

2013: Jan Lapins; Bernt Lindelöf; Anders Ljung; Lennart Emtestam; Ada Girnita; Mari-Anne Hedblad; Johan Hansson
[Synchronous multiple primary melanoma are often missed. Increased attention to the patient's entire skin is required for early diagnosis].
Läkartidningen 2013;110(8):410-2.
2012: Huiyuan Zheng; Ada Girnita; Iulian Oprea; Hongchang Shen; Radu Stefanescu; Claire Worrall; Leonard Girnita
β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):20620-5.
2012: Huiyuan Zheng; Ada Girnita; Tarik Issad; Stefan Seregard; Hongchang Shen; Claire Worrall; Leonard Girnita
Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(18):7055-60.
2012: Ada Girnita; Leonard Girnita; A Grönberg; H Zheng; Mona Ståhle
Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor.
Oncogene 2012;31(3):352-65.
2010: Shucheng Yin; Ada Girnita; Thomas Strömberg; Zahidul Khan; Sandra Andersson; Huiyuan Zheng; Christer Ericsson; Magnus Axelson; Monica Nistér; Olle Larsson; Tomas J Ekström; Leonard Girnita
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma.
Neuro-oncology 2010;12(1):19-27.
2008: Mario A Economou; Sandra Andersson; Daiana Vasilcanu; Charlotta All-Ericsson; Eline Menu; Ada Girnita; Leonard Girnita; Magnus Axelson; Stefan Seregard; Olle Larsson
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
Acta ophthalmologica 2008;86 Thesis 4():35-41.
2008: Ada Girnita; Charlotta All-Ericsson; Mario A Economou; Kristina Aström; Magnus Axelson; Stefan Seregard; Olle Larsson; Leonard Girnita
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Acta ophthalmologica 2008;86 Thesis 4():26-34.
2008: Mario A Economou; Sandra Andersson; Daiana Vasilcanu; Charlotta All-Ericsson; Eline Menu; Ada Girnita; Leonard Girnita; Magnus Axelson; Stefan Seregard; Olle Larsson
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
Investigative ophthalmology & visual science 2008;49(6):2337-42.
2008: Maria Törnkvist; Natalia Natalishvili; Yuntao Xie; Ada Girnita; Pádraig D'Arcy; Bertha Brodin; Magnus Axelson; Leonard Girnita
Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth.
Biochemical and biophysical research communications 2008;368(3):793-800.
2008: Radu Vasilcanu; Daiana Vasilcanu; L Rosengren; N Natalishvili; B Sehat; S Yin; Ada Girnita; Magnus Axelson; Leonard Girnita; Olle Larsson
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.
Oncogene 2008;27(11):1629-38.
2008: Radu Vasilcanu; Daiana Vasilcanu; Bita Sehat; Shucheng Yin; Ada Girnita; Magnus Axelson; Leonard Girnita
Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.
Molecular pharmacology 2008;73(3):930-9.
2007: Leonard Girnita; Sudha K Shenoy; Bita Sehat; Radu Vasilcanu; Daiana Vasilcanu; Ada Girnita; Robert J Lefkowitz; Olle Larsson
Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
The Journal of biological chemistry 2007;282(15):11329-38.
2007: Olle Larsson; Ada Girnita; Leonard Girnita
Role of insulin-like growth factor 1 receptor signalling in cancer.
British journal of cancer 2007;96 Suppl():R2-6.
2006: Linda Rosengren; Daiana Vasilcanu; Radu Vasilcanu; Sandra Fickenscher; Bita Sehat; Nathalia Natalishvili; Sean Naughton; Shucheng Yin; Ada Girnita; Leonard Girnita; Magnus Axelson; Olle Larsson
IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-).
Biochemical and biophysical research communications 2006;347(4):1059-66.
2006: Daiana Vasilcanu; Wen-Hui Weng; Ada Girnita; Weng-Onn Lui; Radu Vasilcanu; Magnus Axelson; Olle Larsson; Catharina Larsson; Leonard Girnita
The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection.
Oncogene 2006;25(22):3186-95.
2006: Ada Girnita; Charlotta All-Ericsson; Mario A Economou; Kristina Aström; Magnus Axelson; Stefan Seregard; Olle Larsson; Leonard Girnita
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(4):1383-91.
2005: Elfar Ulfarsson; Alexandra Karström; Shucheng Yin; Ada Girnita; Daiana Vasilcanu; Marja Thoren; Gunnar Kratz; Jan Hillman; Magnus Axelson; Olle Larsson; Leonard Girnita
Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4674-80.
2005: Leonard Girnita; Sudha K Shenoy; Bita Sehat; Radu Vasilcanu; Ada Girnita; Robert J Lefkowitz; Olle Larsson
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
The Journal of biological chemistry 2005;280(26):24412-9.
2005: Olle Larsson; Ada Girnita; Leonard Girnita
Role of insulin-like growth factor 1 receptor signalling in cancer.
British journal of cancer 2005;92(12):2097-101.
2004: Daiana Vasilcanu; Ada Girnita; Leonard Girnita; Radu Vasilcanu; Magnus Axelson; Olle Larsson
The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway.
Oncogene 2004;23(47):7854-62.
2004: Ada Girnita; Leonard Girnita; Fabrizio del Prete; Armando Bartolazzi; Olle Larsson; Magnus Axelson
Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.
Cancer research 2004;64(1):236-42.
2003: Leonard Girnita; Ada Girnita; Olle Larsson
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8247-52.
2000: Leonard Girnita; Ada Girnita; Bertha Brodin; Yuntao Xie; Gunnar Nilsson; Anica Dricu; J Lundeberg; Johan Wejde; Armando Bartolazzi; K G Wiman; Olle Larsson
Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.
Cancer research 2000;60(18):5278-83.
2000: Leonard Girnita; Ada Girnita; M Wang; Jeanne M Meis-Kindblom; Lars-Gunnar Kindblom; Olle Larsson
A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells.
Oncogene 2000;19(37):4298-301.
2000: L Kanter-Lewensohn; Leonard Girnita; Ada Girnita; Anica Dricu; G Olsson; L Leech; Gunnar Nilsson; A Hilding; Johan Wejde; Kerstin Brismar; Olle Larsson
Tamoxifen-induced cell death in malignant melanoma cells: possible involvement of the insulin-like growth factor-1 (IGF-1) pathway.
Molecular and cellular endocrinology 2000;165(1-2):131-7.