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Leonard Girnita

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Huiyuan Zheng; Ada Girnita; Iulian Oprea; Hongchang Shen; Radu Stefanescu; Claire Worrall; Leonard Girnita
β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.
Huiyuan Zheng; Ada Girnita; Tarik Issad; Stefan Seregard; Hongchang Shen; Claire Worrall; Leonard Girnita
Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.
Ada Girnita; Leonard Girnita; A Grönberg; H Zheng; Mona Ståhle
Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor.

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All Publications

2012: Huiyuan Zheng; Ada Girnita; Iulian Oprea; Hongchang Shen; Radu Stefanescu; Claire Worrall; Leonard Girnita
β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):20620-5.
2012: Huiyuan Zheng; Ada Girnita; Tarik Issad; Stefan Seregard; Hongchang Shen; Claire Worrall; Leonard Girnita
Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(18):7055-60.
2012: Ada Girnita; Leonard Girnita; A Grönberg; H Zheng; Mona Ståhle
Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor.
Oncogene 2012;31(3):352-65.
2011: Jamileh Hashemi; Claire Worrall; Daiana Vasilcanu; Mårten Fryknäs; Luqman Sulaiman; Mohsen Karimi; Wen-Hui Weng; Weng-Onn Lui; Christina Rudduck; Magnus Axelson; Helena Jernberg-Wiklund; Leonard Girnita; Olle Larsson; Catharina Larsson
Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP).
PloS one 2011;6(3):e14757.
2010: Shucheng Yin; Ada Girnita; Thomas Strömberg; Zahidul Khan; Sandra Andersson; Huiyuan Zheng; Christer Ericsson; Magnus Axelson; Monica Nistér; Olle Larsson; Tomas J Ekström; Leonard Girnita
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma.
Neuro-oncology 2010;12(1):19-27.
2009: Leonard Girnita; Sven Sahlin; Abiel Orrego; Stefan Seregard
Malignant solitary fibrous tumour of the orbit.
Acta ophthalmologica 2009;87(4):464-7.
2009: Natalia Natalishvili; Magnus Axelson; Leonard Girnita; Olle Larsson; Daiana Vasilcanu
Aberrant intracellular IGF-1R beta-subunit makes receptor knockout cells (IGF1R-/-) susceptible to oncogenic transformation.
Experimental cell research 2009;315(8):1458-67.
2008: Mario A Economou; Jiangmei Wu; Daiana Vasilcanu; Linda Rosengren; Charlotta All-Ericsson; Ingeborg van der Ploeg; Eline Menu; Leonard Girnita; Magnus Axelson; Olle Larsson; Stefan Seregard; Anders Kvanta
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.
Acta ophthalmologica 2008;86 Thesis 4():42-9.
2008: Mario A Economou; Sandra Andersson; Daiana Vasilcanu; Charlotta All-Ericsson; Eline Menu; Ada Girnita; Leonard Girnita; Magnus Axelson; Stefan Seregard; Olle Larsson
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
Acta ophthalmologica 2008;86 Thesis 4():35-41.
2008: Ada Girnita; Charlotta All-Ericsson; Mario A Economou; Kristina Aström; Magnus Axelson; Stefan Seregard; Olle Larsson; Leonard Girnita
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Acta ophthalmologica 2008;86 Thesis 4():26-34.
2008: Mario A Economou; Charlotta All-Ericsson; Vladimir Bykov; Leonard Girnita; Armando Bartolazzi; Olle Larsson; Stefan Seregard
Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications.
Acta ophthalmologica 2008;86 Thesis 4():20-5.
2008: Bita Sehat; Sandra Andersson; Leonard Girnita; Olle Larsson
Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis.
Cancer research 2008;68(14):5669-77.
2008: Mario A Economou; Jiangmei Wu; Daiana Vasilcanu; Linda Rosengren; Charlotta All-Ericsson; Ingeborg van der Ploeg; Eline Menu; Leonard Girnita; Magnus Axelson; Olle Larsson; Stefan Seregard; Anders Kvanta
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor.
Investigative ophthalmology & visual science 2008;49(6):2620-6.
2008: Mario A Economou; Sandra Andersson; Daiana Vasilcanu; Charlotta All-Ericsson; Eline Menu; Ada Girnita; Leonard Girnita; Magnus Axelson; Stefan Seregard; Olle Larsson
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma.
Investigative ophthalmology & visual science 2008;49(6):2337-42.
2008: Maria Törnkvist; Natalia Natalishvili; Yuntao Xie; Ada Girnita; Pádraig D'Arcy; Bertha Brodin; Magnus Axelson; Leonard Girnita
Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth.
Biochemical and biophysical research communications 2008;368(3):793-800.
2008: Radu Vasilcanu; Daiana Vasilcanu; L Rosengren; N Natalishvili; B Sehat; S Yin; Ada Girnita; Magnus Axelson; Leonard Girnita; Olle Larsson
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.
Oncogene 2008;27(11):1629-38.
2008: Radu Vasilcanu; Daiana Vasilcanu; Bita Sehat; Shucheng Yin; Ada Girnita; Magnus Axelson; Leonard Girnita
Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.
Molecular pharmacology 2008;73(3):930-9.
2007: Anton Razuvaev; Bimma Henderson; Leonard Girnita; Olle Larsson; Magnus Axelson; Ulf Hedin; Joy Roy
The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling.
Journal of vascular surgery 2007;46(1):108-15.
2007: Leonard Girnita; Sudha K Shenoy; Bita Sehat; Radu Vasilcanu; Daiana Vasilcanu; Ada Girnita; Robert J Lefkowitz; Olle Larsson
Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
The Journal of biological chemistry 2007;282(15):11329-38.
2007: Bita Sehat; Sandra Andersson; Radu Vasilcanu; Leonard Girnita; Olle Larsson
Role of ubiquitination in IGF-1 receptor signaling and degradation.
PloS one 2007;2(4):e340.
2007: Olle Larsson; Ada Girnita; Leonard Girnita
Role of insulin-like growth factor 1 receptor signalling in cancer.
British journal of cancer 2007;96 Suppl():R2-6.
2006: Linda Rosengren; Daiana Vasilcanu; Radu Vasilcanu; Sandra Fickenscher; Bita Sehat; Nathalia Natalishvili; Sean Naughton; Shucheng Yin; Ada Girnita; Leonard Girnita; Magnus Axelson; Olle Larsson
IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-).
Biochemical and biophysical research communications 2006;347(4):1059-66.
2006: Daiana Vasilcanu; Wen-Hui Weng; Ada Girnita; Weng-Onn Lui; Radu Vasilcanu; Magnus Axelson; Olle Larsson; Catharina Larsson; Leonard Girnita
The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection.
Oncogene 2006;25(22):3186-95.
2006: Ada Girnita; Charlotta All-Ericsson; Mario A Economou; Kristina Aström; Magnus Axelson; Stefan Seregard; Olle Larsson; Leonard Girnita
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(4):1383-91.
2006: Thomas Strömberg; Simon Ekman; Leonard Girnita; Lina Dimberg; Olle Larsson; Magnus Axelson; Johan Lennartsson; Ulf Hellman; Kristina Carlson; Anders Osterborg; Karin Vanderkerken; Kenneth Nilsson; Helena Jernberg-Wiklund
IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.
Blood 2006;107(2):669-78.
2006: Eline Menu; Helena Jernberg-Wiklund; Thomas Stromberg; Hendrik De Raeve; Leonard Girnita; Olle Larsson; Magnus Axelson; Kewal Asosingh; Kenneth Nilsson; Ben Van Camp; Karin Vanderkerken
Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
Blood 2006;107(2):655-60.
2005: Mario A Economou; Charlotta All-Ericsson; Vladimir Bykov; Leonard Girnita; Armando Bartolazzi; Olle Larsson; Stefan Seregard
Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications.
Investigative ophthalmology & visual science 2005;46(12):4372-5.
2005: Elfar Ulfarsson; Alexandra Karström; Shucheng Yin; Ada Girnita; Daiana Vasilcanu; Marja Thoren; Gunnar Kratz; Jan Hillman; Magnus Axelson; Olle Larsson; Leonard Girnita
Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4674-80.
2005: Leonard Girnita; Sudha K Shenoy; Bita Sehat; Radu Vasilcanu; Ada Girnita; Robert J Lefkowitz; Olle Larsson
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
The Journal of biological chemistry 2005;280(26):24412-9.
2005: Olle Larsson; Ada Girnita; Leonard Girnita
Role of insulin-like growth factor 1 receptor signalling in cancer.
British journal of cancer 2005;92(12):2097-101.
2005: Jan Ahlén; Johan Wejde; Otte Brosjö; Anette Von Rosen; Wen-Hui Weng; Leonard Girnita; Olle Larsson; Catharina Larsson
Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(1):206-16.
2004: Daiana Vasilcanu; Ada Girnita; Leonard Girnita; Radu Vasilcanu; Magnus Axelson; Olle Larsson
The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway.
Oncogene 2004;23(47):7854-62.
2004: Charlotta All-Ericsson; Leonard Girnita; Anja Müller-Brunotte; Bertha Brodin; Stefan Seregard; Arne Ostman; Olle Larsson
c-Kit-dependent growth of uveal melanoma cells: a potential therapeutic target?
Investigative ophthalmology & visual science 2004;45(7):2075-82.
2004: Ada Girnita; Leonard Girnita; Fabrizio del Prete; Armando Bartolazzi; Olle Larsson; Magnus Axelson
Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.
Cancer research 2004;64(1):236-42.
2003: Yuntao Xie; Maria Törnkvist; Yan Aalto; Gunnar Nilsson; Leonard Girnita; Balint Nagy; Sakari Knuutila; Olle Larsson
Gene expression profile by blocking the SYT-SSX fusion gene in synovial sarcoma cells. Identification of XRCC4 as a putative SYT-SSX target gene.
Oncogene 2003;22(48):7628-31.
2003: Alessandra Gasbarri; Fabrizio del Prete; Leonard Girnita; MP Martegani; Pier Giorgio Natali; Armando Bartolazzi
CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage.
Melanoma research 2003;13(4):325-37.
2003: Leonard Girnita; Ada Girnita; Olle Larsson
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8247-52.
2002: Charlotta All-Ericsson; Leonard Girnita; Stefan Seregard; Armando Bartolazzi; Martine J Jager; Olle Larsson
Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target.
Investigative ophthalmology & visual science 2002;43(1):1-8.
2000: Leonard Girnita; Ada Girnita; Bertha Brodin; Yuntao Xie; Gunnar Nilsson; Anica Dricu; J Lundeberg; Johan Wejde; Armando Bartolazzi; K G Wiman; Olle Larsson
Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.
Cancer research 2000;60(18):5278-83.
2000: Leonard Girnita; Ada Girnita; M Wang; Jeanne M Meis-Kindblom; Lars-Gunnar Kindblom; Olle Larsson
A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells.
Oncogene 2000;19(37):4298-301.
2000: L Kanter-Lewensohn; Leonard Girnita; Ada Girnita; Anica Dricu; G Olsson; L Leech; Gunnar Nilsson; A Hilding; Johan Wejde; Kerstin Brismar; Olle Larsson
Tamoxifen-induced cell death in malignant melanoma cells: possible involvement of the insulin-like growth factor-1 (IGF-1) pathway.
Molecular and cellular endocrinology 2000;165(1-2):131-7.
2000: Leonard Girnita; M Wang; Y Xie; Gunnar Nilsson; Anica Dricu; Johan Wejde; Olle Larsson
Inhibition of N-linked glycosylation down-regulates insulin-like growth factor-1 receptor at the cell surface and kills Ewing's sarcoma cells: therapeutic implications.
Anti-cancer drug design 2000;15(1):67-72.
2000: L Kanter-Lewensohn; Anica Dricu; Leonard Girnita; Johan Wejde; Olle Larsson
Expression of insulin-like growth factor-1 receptor (IGF-1R) and p27Kip1 in melanocytic tumors: a potential regulatory role of IGF-1 pathway in distribution of p27Kip1 between different cyclins.
Growth factors (Chur, Switzerland) 2000;17(3):193-202.
1999: M Wang; Yuntao Xie; Leonard Girnita; Gunnar Nilsson; Anica Dricu; Johan Wejde; Olle Larsson
Regulatory role of mevalonate and N-linked glycosylation in proliferation and expression of the EWS/FLI-1 fusion protein in Ewing's sarcoma cells.
Experimental cell research 1999;246(1):38-46.