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Michael Givskov

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Wen-Chi Chiang; Michael Givskov; Niels Høiby; Peter Østrup Jensen; Thomas E Nielsen; Martin Nilsson; Tim Tolker-Nielsen
Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms.
Ana S Ferreira; Michael Givskov; Jorg Becker; Fábio Fernandes; Vítor H Oliveira; Robert P Ryan; Inês N Silva; Leonilde M Moreira
Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation, and virulence.
Song Lin Chua; Yicai Chen; Staffan Kjelleberg; Scott A Rice; Morten Theil Rybtke; Sean Yang-Yi Tan; Tim Tolker-Nielsen; Liang Yang; Michael Givskov
Bis-(3'-5')-cyclic dimeric GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa.

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All Publications

2013: Wen-Chi Chiang; Michael Givskov; Niels Høiby; Peter Østrup Jensen; Thomas E Nielsen; Martin Nilsson; Tim Tolker-Nielsen
Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms.
Antimicrobial agents and chemotherapy 2013;57(5):2352-61.
2013: Ana S Ferreira; Michael Givskov; Jorg Becker; Fábio Fernandes; Vítor H Oliveira; Robert P Ryan; Inês N Silva; Leonilde M Moreira
Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation, and virulence.
Applied and environmental microbiology 2013;79(9):3009-20.
2013: Song Lin Chua; Yicai Chen; Staffan Kjelleberg; Scott A Rice; Morten Theil Rybtke; Sean Yang-Yi Tan; Tim Tolker-Nielsen; Liang Yang; Michael Givskov
Bis-(3'-5')-cyclic dimeric GMP regulates antimicrobial peptide resistance in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 2013;57(5):2066-75.
2013: Maria Pihl; Marie Skepö; Gunnel Svensäter; Tim Tolker-Nielsen; Anna Arvidsson; Michael Givskov; Martin Nilsson; Julia R Davies
Biofilm formation by Staphylococcus epidermidis on peritoneal dialysis catheters and the effects of extracellular products from Pseudomonas aeruginosa.
Pathogens and disease 2013;67(3):192-8.
2013: Danielle M Stacy; Tim Tolker-Nielsen; Jacob W Brummond; Janie W Clausen; Michael Givskov; Casper L Hansen; Sebastian T Le Quement; Thomas E Nielsen; Helen E Blackwell
Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators.
Organic & biomolecular chemistry 2013;11(6):938-54.
2013: Mustafa Fazli; Michael Givskov; Yvonne McCarthy; Robert P Ryan; Tim Tolker-Nielsen
The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349.
MicrobiologyOpen 2013;2(1):105-22.
2013: Sean Yang-Yi Tan; Leif Percival Andersen; Song Lin Chua; Michael Givskov; Niels Høiby; Yang Liu; Zhijun Song; Liang Yang
Comparative Genomic Analysis of Rapid Evolution of an Extreme-Drug-Resistant Acinetobacter baumannii Clone.
Genome biology and evolution 2013;5(5):807-18.
2013: Søren Skovstrup; Tim Tolker-Nielsen; Michael Givskov; Thomas Hansen; Morten Harmsen; Tim Holm Jakobsen; Sebastian Le Quement; Thomas E Nielsen; Olivier Taboureau
Identification of LasR ligands through a virtual screening approach.
ChemMedChem 2013;8(1):157-63.
2013: Stephan Schwager; Kirsty Agnoli; Aurelien Carlier; Friederike Feldmann; Michael Givskov; Manuela Köthe; Leo Eberl
Identification of Burkholderia cenocepacia strain H111 virulence factors using nonmammalian infection hosts.
Infection and immunity 2013;81(1):143-53.
2013: Roberto A Bobadilla Fazzini; Michael Givskov; Jacek Puchałka; Mette E Skindersoe; Piotr Bielecki; Vitor A P Martins sos Santos
Protoanemonin: a natural quorum sensing inhibitor that selectively activates iron starvation response.
Environmental microbiology 2013;15(1):111-20.
2012: Vitaly V Komnatnyy; Michael Givskov; Thomas E Nielsen
Solid-phase synthesis of structurally diverse heterocycles by an amide-ketone condensation/N-acyliminium pictet-spengler sequence.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(52):16793-800.
2012: Lianbo Zhang; Wen-Chi Chiang; Qingguo Gao; Michael Givskov; Tim Tolker-Nielsen; Liang Yang; Guang Zhang
The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms.
Microbiology (Reading, England) 2012;158(Pt 12):3014-9.
2012: Michael Givskov
Beyond nutrition: health-promoting foods by quorum-sensing inhibition.
Future microbiology 2012;7(9):1025-8.
2012: Maria van Gennip; Morten Alhede; Lisa D Christensen; Michael Givskov; Niels Høiby; Peter Østrup Jensen; Klaus Qvortrup; Thomas Bjarnsholt
Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo.
Infection and immunity 2012;80(8):2601-7.
2012: Morten T Rybtke; Bradley R Borlee; Michael Givskov; Morten Hentzer; Yasuhiko Irie; Keiji Murakami; Thomas E Nielsen; Matthew R Parsek; Tim Tolker-Nielsen
Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa.
Applied and environmental microbiology 2012;78(15):5060-9.
2012: Morten Alhede; Michael Givskov; Niels Høiby; Ramon Liebrechts; Klaus Qvortrup; Thomas Bjarnsholt
Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition.
FEMS immunology and medical microbiology 2012;65(2):335-42.
2012: Liang Yang; Zhijun Song; Hong Wu; Søren Damkiaer; Michael Givskov; Wang Hengzhuang; Niels Høiby; Nicholas Jochumsen; Søren Molin
Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa.
FEMS immunology and medical microbiology 2012;65(2):366-76.
2012: Wen-Chi Chiang; Michael Givskov; Martin Nilsson; Sünje Johanna Pamp; Tim Tolker-Nielsen
The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms.
FEMS immunology and medical microbiology 2012;65(2):245-56.
2012: Vibeke B Rudkjøbing; Trine R Thomsen; Morten Alhede; Michael Givskov; Niels Høiby; Ulla R Johansen; Kasper N Kragh; Per H Nielsen; Thomas Bjarnsholt
The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients.
FEMS immunology and medical microbiology 2012;65(2):236-44.
2012: Liang Yang; Niels Høiby; Yang Liu; Søren Molin; Zhijun Song; Hong Wu; Michael Givskov
Combating biofilms.
FEMS immunology and medical microbiology 2012;65(2):146-57.
2012: Tim Holm Jakobsen; Peter Østrup Jensen; Thomas O Larsen; Claus Moser; Kristian Fog Nielsen; Richard K Phipps; Thomas Bovbjerg Rasmussen; Meenakshi Sundaram Shanmugham; Mette E Skindersoe; David Tanner; Friedrich Uthe; Maria van Gennip; Morten Alhede; Thomas Bjarnsholt; Lisa D Christensen; Leo Eberl; Karlheinz Friedrich; Niels Høiby; Michael Givskov
Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing.
Antimicrobial agents and chemotherapy 2012;56(5):2314-25.
2012: Lisa D Christensen; Morten Alhede; Thomas Bjarnsholt; Niels Høiby; Hans Petter Hougen; Tim H Jakobsen; Maria van Gennip; Michael Givskov
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
The Journal of antimicrobial chemotherapy 2012;67(5):1198-206.
2012: Tim Holm Jakobsen; Thomas O Larsen; Richard K Phipps; Mette Skindersoe; Maria van Gennip; Morten Alhede; Thomas Bjarnsholt; Steinn Kristinn Bragason; Lisa D Christensen; Niels Høiby; Michael Givskov
Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa.
Applied and environmental microbiology 2012;78(7):2410-21.
2012: Shanika A Crusz; Stephen P Diggle; Michael Givskov; Roman Popat; Morten Theil Rybtke; Tim Tolker-Nielsen; Miguel Cámara; Paul Williams
Bursting the bubble on bacterial biofilms: a flow cell methodology.
Biofouling 2012;28(8):835-42.
2011: Vibeke B Rudkjøbing; Trine R Thomsen; Morten Alhede; Michael Givskov; Niels Høiby; Ulla R Johansen; Kasper N Kragh; Per H Nielsen; Thomas Bjarnsholt
True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis.
Journal of clinical microbiology 2011;49(12):4352-5.
2011: Mustafa Fazli; Michael Givskov; Karsten Niehaus; Martin Nilsson; Aileen O'Connell; Robert P Ryan; J Maxwell Dow; Tim Tolker-Nielsen
The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia.
Molecular microbiology 2011;82(2):327-41.
2011: Hong Wu; Baoleri Lee; Liang Yang; Hengzuang Wang; Michael Givskov; Søren Molin; Niels Høiby; Zhijun Song
Effects of ginseng on Pseudomonas aeruginosa motility and biofilm formation.
FEMS immunology and medical microbiology 2011;62(1):49-56.
2011: Mustafa Fazli; Thomas Bjarnsholt; Klaus Kirketerp-Møller; Anne Jørgensen; Claus Bøgelund Andersen; Michael Givskov; Tim Tolker-Nielsen
Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2011;19(3):387-91.
2011: Martin Nilsson; Wen-Chi Chiang; Mustafa Fazli; Morten Gjermansen; Michael Givskov; Tim Tolker-Nielsen
Influence of putative exopolysaccharide genes on Pseudomonas putida KT2440 biofilm stability.
Environmental microbiology 2011;13(5):1357-69.
2011: Niels Høiby; Peter Østrup Jensen; Helle Krogh Johansen; Søren Molin; Claus Moser; Zhi-jun Song; Tim Tolker-Nielsen; Oana Ciofu; Michael Givskov; Thomas Bjarnsholt
The clinical impact of bacterial biofilms.
International journal of oral science 2011;3(2):55-65.
2011: Morten T Rybtke; Peter Østrup Jensen; Niels Høiby; Michael Givskov; Tim Tolker-Nielsen; Thomas Bjarnsholt
The implication of Pseudomonas aeruginosa biofilms in infections.
Inflammation & allergy drug targets 2011;10(2):141-57.
2011: Johanna Schwenteit; Lone Gram; Kristian F Nielsen; Olafur H Fridjonsson; Uwe T Bornscheuer; Michael Givskov; Bjarnheidur Gudmundsdottir
Quorum sensing in Aeromonas salmonicida subsp. achromogenes and the effect of the autoinducer synthase AsaI on bacterial virulence.
Veterinary microbiology 2011;147(3-4):389-97.
2011: Morten Alhede; Marie Allesen-Holm; Lisa D Christensen; Michael Givskov; Niels Høiby; Peter Østrup Jensen; Kasper Nørskov Kragh; Søren Molin; Anne K Nielsen; Matt Parsek; Klaus Qvortrup; Tim Tolker-Nielsen; Maria van Gennip; Dan Wozniak; Thomas Bjarnsholt
Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm.
PloS one 2011;6(11):e27943.
2011: Tim Holm Jakobsen; Maria van Gennip; Lisa D Christensen; Thomas Bjarnsholt; Michael Givskov
Qualitative and quantitative determination of quorum sensing inhibition in vitro.
Methods in molecular biology (Clifton, N.J.) 2011;692():253-63.
2011: Lisa D Christensen; Maria van Gennip; Tim Holm Jakobsen; Michael Givskov; Thomas Bjarnsholt
Imaging N-acyl homoserine lactone quorum sensing in vivo.
Methods in molecular biology (Clifton, N.J.) 2011;692():147-57.
2010: David M Marsden; Rebecca L Nicholson; Mette E Skindersoe; Warren R J D Galloway; Hannah F Sore; Michael Givskov; George P C Salmond; Mark Ladlow; Martin Welch; David R Spring
Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening.
Organic & biomolecular chemistry 2010;8(23):5313-23.
2010: Mette Burmølle; Trine Rolighed Thomsen; Mustafa Fazli; Irene Dige; Lise Christensen; Preben Homøe; Michael Tvede; Bente Nyvad; Tim Tolker-Nielsen; Michael Givskov; Claus Moser; Klaus Kirketerp-Møller; Helle Krogh Johansen; Niels Høiby; Peter Østrup Jensen; Søren J Sørensen; Thomas Bjarnsholt
Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections.
FEMS immunology and medical microbiology 2010;59(3):324-36.
2010: Peter Østrup Jensen; Michael Givskov; Thomas Bjarnsholt; Claus Moser
The immune system vs. Pseudomonas aeruginosa biofilms.
FEMS immunology and medical microbiology 2010;59(3):292-305.
2010: Alan R Smyth; Paramita M Cifelli; Catharine A Ortori; Karima Righetti; Sarah Lewis; Penny Erskine; Elaine D Holland; Michael Givskov; Paul Williams; Miguel Cámara; David A Barrett; Alan Knox
Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial.
Pediatric pulmonology 2010;45(4):356-62.
2010: Niels Høiby; Thomas Bjarnsholt; Michael Givskov; Søren Molin; Oana Ciofu
Antibiotic resistance of bacterial biofilms.
International journal of antimicrobial agents 2010;35(4):322-32.
2010: Christian Garde; Thomas Bjarnsholt; Michael Givskov; Tim Holm Jakobsen; Morten Hentzer; Anetta Claussen; Kim Sneppen; Jesper Ferkinghoff-Borg; Thomas Sams
Quorum sensing regulation in Aeromonas hydrophila.
Journal of molecular biology 2010;396(4):849-57.
2010: Thomas Bjarnsholt; Maria van Gennip; Tim H Jakobsen; Lisa D Christensen; Peter Østrup Jensen; Michael Givskov
In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect.
Nature protocols 2010;5(2):282-93.
2010: Maria Werthén; Lina Henriksson; Peter Østrup Jensen; Claus Sternberg; Michael Givskov; Thomas Bjarnsholt
An in vitro model of bacterial infections in wounds and other soft tissues.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010;118(2):156-64.
2010: Andrew Y Koh; Per J Mikkelsen; Roger S Smith; Kathleen T Coggshall; Akinobu Kamei; Michael Givskov; Stephen Lory; Gerald B Pier
Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination.
PloS one 2010;5(12):e15131.
2010: Thomas Bjarnsholt; Peter Østrup Jensen; Tim Holm Jakobsen; Richard Phipps; Anne Kirstine Nielsen; Morten Theil Rybtke; Tim Tolker-Nielsen; Michael Givskov; Niels Høiby; Oana Ciofu
Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients.
PloS one 2010;5(4):e10115.
2010: Thomas Bjarnsholt; Tim Tolker-Nielsen; Niels Høiby; Michael Givskov
Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control.
Expert reviews in molecular medicine 2010;12():e11.
2010: Trine R Thomsen; Martin S Aasholm; Vibeke B Rudkjøbing; Aaron Marc Saunders; Thomas Bjarnsholt; Michael Givskov; Klaus Kirketerp-Møller; Per H Nielsen
The bacteriology of chronic venous leg ulcer examined by culture-independent molecular methods.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2010;18(1):38-49.
2010: M Kolpen; C R Hansen; Thomas Bjarnsholt; Claus Moser; Lisa D Christensen; M van Gennip; Oana Ciofu; L Mandsberg; Arsalan Kharazmi; Gerd Döring; Michael Givskov; Niels Høiby; Peter Østrup Jensen
Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis.
Thorax 2010;65(1):57-62.
2009: Liang Yang; Martin Nilsson; Morten Gjermansen; Michael Givskov; Tim Tolker-Nielsen
Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation.
Molecular microbiology 2009;74(6):1380-92.
2009: Maria van Gennip; Claus Moser; Louise D Christensen; Thomas Bjarnsholt; Henrik Calum; Peter Østrup Jensen; Lars Christophersen; Hans Petter Hougen; Oana Ciofu; Søren Molin; Michael Givskov; Niels Høiby
Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy 2009;64(6):1241-50.
2009: Mustafa Fazli; Thomas Bjarnsholt; Klaus Kirketerp-Møller; Bo Jørgensen; Anders Schou Andersen; Karen A Krogfelt; Michael Givskov; Tim Tolker-Nielsen
Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds.
Journal of clinical microbiology 2009;47(12):4084-9.
2009: Morten Alhede; Thomas Bjarnsholt; Peter Østrup Jensen; Richard K Phipps; Claus Moser; Lars Christophersen; Louise Dahl Christensen; Maria van Gennip; Matthew R Parsek; Niels Høiby; Thomas Bovbjerg Rasmussen; Michael Givskov
Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes.
Microbiology (Reading, England) 2009;155(Pt 11):3500-8.
2009: Thomas Bjarnsholt; Tim Tolker-Nielsen; Michael Givskov; Martin Janssen; Lise Hanne Christensen
Detection of bacteria by fluorescence in situ hybridization in culture-negative soft tissue filler lesions.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2009;35 Suppl 2():1620-4.
2009: Maria Van Gennip; Louise Dahl Christensen; Morten Alhede; Richard Phipps; Peter Østrup Jensen; Lars Christophersen; Sünje Johanna Pamp; Claus Moser; Per Jensen Mikkelsen; Andrew Y Koh; Tim Tolker-Nielsen; Gerald B Pier; Niels Høiby; Michael Givskov; Thomas Bjarnsholt
Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2009;117(7):537-46.
2009: Thomas Bjarnsholt; Peter Østrup Jensen; Mark J Fiandaca; Jette Pedersen; Christine Rønne Hansen; Claus Bøgelund Andersen; Tacjana Pressler; Michael Givskov; Niels Høiby
Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients.
Pediatric pulmonology 2009;44(6):547-58.
2009: Liang Yang; Morten Theil Rybtke; Tim Holm Jakobsen; Morten Hentzer; Thomas Bjarnsholt; Michael Givskov; Tim Tolker-Nielsen
Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors.
Antimicrobial agents and chemotherapy 2009;53(6):2432-43.
2009: Henrik Calum; Claus Moser; Peter Østrup Jensen; L Christophersen; D S Maling; M van Gennip; Thomas Bjarnsholt; Hans Petter Hougen; Michael Givskov; G K Jacobsen; Niels Høiby
Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection.
Clinical and experimental immunology 2009;156(1):102-10.
2009: Mette E Skindersoe; Louise H Zeuthen; Susanne Brix; Lisbeth N Fink; James Lazenby; Christine Whittall; Paul Williams; Stephen P Diggle; Hanne Froekiaer; Margaret Cooley; Michael Givskov
Pseudomonas aeruginosa quorum-sensing signal molecules interfere with dendritic cell-induced T-cell proliferation.
FEMS immunology and medical microbiology 2009;55(3):335-45.
2009: Claus Moser; Maria Van Gennip; Thomas Bjarnsholt; Peter Østrup Jensen; Baoleri Lee; Hans Petter Hougen; Henrik Calum; Oana Ciofu; Michael Givskov; Søren Molin; Niels Høiby
Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2009;117(2):95-107.
2008: Mette E Skindersoe; Morten Alhede; Richard Phipps; Liang Yang; Peter O Jensen; Thomas Bovbjerg Rasmussen; Thomas Bjarnsholt; Tim Tolker-Nielsen; Niels Høiby; Michael Givskov
Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 2008;52(10):3648-63.
2008: Kim Barken; Sünje Johanna Pamp; Liang Yang; Morten Gjermansen; Jacob J Bertrand; Mikkel Klausen; Michael Givskov; Cynthia B Whitchurch; Joanne N Engel; Tim Tolker-Nielsen
Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.
Environmental microbiology 2008;10(9):2331-43.
2008: M D P Willcox; Hua Zhu; T C R Conibear; Emma B H Hume; Michael Givskov; Staffan Kjelleberg; Scott A Rice
Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis.
Microbiology (Reading, England) 2008;154(Pt 8):2184-94.
2008: Klaus Kirketerp-Møller; Peter Ø Jensen; Mustafa Fazli; Kit G Madsen; Jette Pedersen; Claus Moser; Tim Tolker-Nielsen; Niels Høiby; Michael Givskov; Thomas Bjarnsholt
Distribution, organization, and ecology of bacteria in chronic wounds.
Journal of clinical microbiology 2008;46(8):2717-22.
2008: Carsten Matz; Ana Maria Moreno; Morten Alhede; Mike Manefield; Alan R Hauser; Michael Givskov; Staffan Kjelleberg
Pseudomonas aeruginosa uses type III secretion system to kill biofilm-associated amoebae.
The ISME journal 2008;2(8):843-52.
2008: Søren Kristiansen; Thomas Bjarnsholt; Dinah Adeltoft; Peter Ifversen; Michael Givskov
The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2008;116(5):361-71.
2008: Thomas Bjarnsholt; Michael Givskov
Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?
Current infectious disease reports 2008;10(1):22-8.
2008: Scott A Rice; Diane McDougald; Michael Givskov; Staffan Kjelleberg
Detection and inhibition of bacterial cell-cell communication.
Methods in molecular biology (Clifton, N.J.) 2008;431():55-68.
2008: Thomas Bjarnsholt; Klaus Kirketerp-Møller; Peter Østrup Jensen; Kit G Madsen; Richard Phipps; Karen Krogfelt; Niels Høiby; Michael Givskov
Why chronic wounds will not heal: a novel hypothesis.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2008;16(1):2-10.
2008: Mette E Skindersoe; Piers Ettinger-Epstein; Thomas Bovbjerg Rasmussen; Thomas Bjarnsholt; Rocky de Nys; Michael Givskov
Quorum sensing antagonism from marine organisms.
Marine biotechnology (New York, N.Y.) 2008;10(1):56-63.
2007: Maria Rasch; Vicky Gaedt Kastbjerg; Jesper Bartholin Bruhn; Inger Dalsgaard; Michael Givskov; Lone Gram
Quorum sensing signals are produced by Aeromonas salmonicida and quorum sensing inhibitors can reduce production of a potential virulence factor.
Diseases of aquatic organisms 2007;78(2):105-13.
2007: Niels Høiby; Helle Krogh Johansen; Oana Ciofu; Peter Østrup Jensen; Thomas Bjarnsholt; Michael Givskov
[Foreign body infections--biofilms and quorum sensing].
Ugeskrift for laeger 2007;169(48):4163-6.
2007: Nadine Hoffmann; Baoleri Lee; Morten Hentzer; Thomas Bovbjerg Rasmussen; Zhijun Song; Helle Krogh Johansen; Michael Givskov; Niels Høiby
Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice.
Antimicrobial agents and chemotherapy 2007;51(10):3677-87.
2007: Thomas Bjarnsholt; Klaus Kirketerp-Møller; Søren Kristiansen; Richard Phipps; Anne Kirstine Nielsen; Peter Østrup Jensen; Niels Høiby; Michael Givskov
Silver against Pseudomonas aeruginosa biofilms.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2007;115(8):921-8.
2007: Thomas Bjarnsholt; Michael Givskov
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2007;362(1483):1213-22.
2007: Louise D Christensen; Claus Moser; Peter Østrup Jensen; Thomas Bovbjerg Rasmussen; Lars Christophersen; Staffan Kjelleberg; Naresh Kumar; Niels Høiby; Michael Givskov; Thomas Bjarnsholt
Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model.
Microbiology (Reading, England) 2007;153(Pt 7):2312-20.
2007: Rob Van Houdt; Michael Givskov; Chris W Michiels
Quorum sensing in Serratia.
FEMS microbiology reviews 2007;31(4):407-24.
2007: Peter Østrup Jensen; Thomas Bjarnsholt; Richard Phipps; Thomas Bovbjerg Rasmussen; Henrik Calum; Lars Christoffersen; Claus Moser; Paul Williams; Tacjana Pressler; Michael Givskov; Niels Høiby
Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa.
Microbiology (Reading, England) 2007;153(Pt 5):1329-38.
2007: Liang Yang; Kim Barken; Mette E Skindersoe; Allan B Christensen; Michael Givskov; Tim Tolker-Nielsen
Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa.
Microbiology (Reading, England) 2007;153(Pt 5):1318-28.
2007: Maurizio Labbate; Hua Zhu; Leena Thung; Rani Bandara; Martin R Larsen; Mark D P Willcox; Michael Givskov; Scott A Rice; Staffan Kjelleberg
Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent.
Journal of bacteriology 2007;189(7):2702-11.
2007: Maria Rasch; Thomas Bovbjerg Rasmussen; Jens Bo Andersen; Tobias Persson; Jens Nielsen; Michael Givskov; Lone Gram
Well-known quorum sensing inhibitors do not affect bacterial quorum sensing-regulated bean sprout spoilage.
Journal of applied microbiology 2007;102(3):826-37.
2007: V G Kastbjerg; Kristian Fog Nielsen; Inger Dalsgaard; Maria Rasch; Jesper Bartholin Bruhn; Michael Givskov; Lone Gram
Profiling acylated homoserine lactones in Yersinia ruckeri and influence of exogenous acyl homoserine lactones and known quorum-sensing inhibitors on protease production.
Journal of applied microbiology 2007;102(2):363-74.
2007: Thomas Hjelmgaard; Michael Givskov; John Nielsen
Expedient total synthesis of pyrrothine natural products and analogs.
Organic & biomolecular chemistry 2007;5(2):344-8.
2007: Sara Fexby; Thomas Bjarnsholt; Peter Østrup Jensen; Viktoria Roos; Niels Høiby; Michael Givskov; Per Klemm
Biological Trojan horse: Antigen 43 provides specific bacterial uptake and survival in human neutrophils.
Infection and immunity 2007;75(1):30-4.
2007: Thomas Bjarnsholt; Michael Givskov
The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa.
Analytical and bioanalytical chemistry 2007;387(2):409-14.
2006: Joshua D Shrout; David L Chopp; Collin L Just; Morten Hentzer; Michael Givskov; Matthew R Parsek
The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional.
Molecular microbiology 2006;62(5):1264-77.
2006: Thomas Bovbjerg Rasmussen; Michael Givskov
Quorum sensing inhibitors: a bargain of effects.
Microbiology (Reading, England) 2006;152(Pt 4):895-904.
2006: Thomas Bovbjerg Rasmussen; Michael Givskov
Quorum-sensing inhibitors as anti-pathogenic drugs.
International journal of medical microbiology : IJMM 2006;296(2-3):149-61.
2006: Marie Allesen-Holm; Kim Barken; Liang Yang; Mikkel Klausen; Jeremy S Webb; Staffan Kjelleberg; Søren Molin; Michael Givskov; Tim Tolker-Nielsen
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms.
Molecular microbiology 2006;59(4):1114-28.
2006: Rocky de Nys; Michael Givskov; N Kumar; Staffan Kjelleberg; Peter D Steinberg
Furanones.
Progress in molecular and subcellular biology 2006;42():55-86.
2006: Kerstin Schreiber; Nelli Boes; Martin Eschbach; Lothar Jaensch; Jürgen Wehland; Thomas Bjarnsholt; Michael Givskov; Morten Hentzer; Max Schobert
Anaerobic survival of Pseudomonas aeruginosa by pyruvate fermentation requires an Usp-type stress protein.
Journal of bacteriology 2006;188(2):659-68.
2005: Thomas Bjarnsholt; Peter Østrup Jensen; Thomas Bovbjerg Rasmussen; Lars Christophersen; Henrik Calum; Morten Hentzer; Hans Petter Hougen; Jørgen Rygaard; Claus Moser; Leo Eberl; Niels Høiby; Michael Givskov
Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections.
Microbiology (Reading, England) 2005;151(Pt 12):3873-80.
2005: Birgit Koch; T Liljefors; Tobias Persson; Jens Nielsen; Staffan Kjelleberg; Michael Givskov
The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors.
Microbiology (Reading, England) 2005;151(Pt 11):3589-602.
2005: Alessandra Bragonzi; Dieter Worlitzsch; Gerald B Pier; Petra Timpert; Martina Ulrich; Morten Hentzer; Jens Bo Andersen; Michael Givskov; Massimo Conese; Gerd Doring
Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model.
The Journal of infectious diseases 2005;192(3):410-9.
2005: Maria Rasch; Jens Bo Andersen; Kristian Fog Nielsen; Lars Ravn Flodgaard; Henrik Christensen; Michael Givskov; Lone Gram
Involvement of bacterial quorum-sensing signals in spoilage of bean sprouts.
Applied and environmental microbiology 2005;71(6):3321-30.
2005: Thomas Bovbjerg Rasmussen; Mette E Skindersoe; Thomas Bjarnsholt; Richard K Phipps; Kathrine B Christensen; Peter Ostrup Jensen; Jens Bo Andersen; Birgit Koch; Thomas O Larsen; Morten Hentzer; Leo Eberl; Niels Hoiby; Michael Givskov
Identity and effects of quorum-sensing inhibitors produced by Penicillium species.
Microbiology (Reading, England) 2005;151(Pt 5):1325-40.
2005: Lars Ravn Flodgaard; Paw Dalgaard; Jens Bo Andersen; Kristian Fog Nielsen; Michael Givskov; Lone Gram
Nonbioluminescent strains of Photobacterium phosphoreum produce the cell-to-cell communication signal N-(3-Hydroxyoctanoyl)homoserine lactone.
Applied and environmental microbiology 2005;71(4):2113-20.
2005: Nadine Hoffmann; Thomas Bovbjerg Rasmussen; Peter Østrup Jensen; Charlotte Stub; Morten Hentzer; Søren Molin; Oana Ciofu; Michael Givskov; Helle Krogh Johansen; Niels Høiby
Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis.
Infection and immunity 2005;73(4):2504-14.
2005: Thomas Bovbjerg Rasmussen; Thomas Bjarnsholt; Mette E Skindersoe; Morten Hentzer; Peter Kristoffersen; Manuela Köte; John Nielsen; Leo Eberl; Michael Givskov
Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector.
Journal of bacteriology 2005;187(5):1799-814.
2005: Lars Jelsbak; Michael Givskov; Armin Dale Kaiser
Enhancer-binding proteins with a forkhead-associated domain and the sigma54 regulon in Myxococcus xanthus fruiting body development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3010-5.
2005: Thomas Bjarnsholt; Peter Østrup Jensen; Mette Burmølle; Morten Hentzer; Janus A J Haagensen; Hans Petter Hougen; Henrik Calum; Kit G Madsen; Claus Moser; Søren Molin; Niels Høiby; Michael Givskov
Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent.
Microbiology (Reading, England) 2005;151(Pt 2):373-83.
2005: Tobias Persson; Thomas H Hansen; Thomas Bovbjerg Rasmussen; Mette E Skindersø; Michael Givskov; John Nielsen
Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic.
Organic & biomolecular chemistry 2005;3(2):253-62.
2005: Tobias Persson; Michael Givskov; John Nielsen
Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria.
Current medicinal chemistry 2005;12(26):3103-15.
2004: Jesper Bartholin Bruhn; Allan B Christensen; Lars Ravn Flodgaard; Kristian Fog Nielsen; Thomas O Larsen; Michael Givskov; Lone Gram
Presence of acylated homoserine lactones (AHLs) and AHL-producing bacteria in meat and potential role of AHL in spoilage of meat.
Applied and environmental microbiology 2004;70(7):4293-302.
2004: Thomas Danhorn; Morten Hentzer; Michael Givskov; Matthew R Parsek; Clay Fuqua
Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system.
Journal of bacteriology 2004;186(14):4492-501.
2004: Hua Zhu; Rani Bandara; Tim C R Conibear; Sophy J Thuruthyil; Scott A Rice; Staffan Kjelleberg; Michael Givskov; Mark D P Willcox
Pseudomonas aeruginosa with lasI quorum-sensing deficiency during corneal infection.
Investigative ophthalmology & visual science 2004;45(6):1897-903.
2004: H Wu; Zhijun Song; Morten Hentzer; Jens Bo Andersen; Søren Molin; Michael Givskov; Niels Høiby
Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice.
The Journal of antimicrobial chemotherapy 2004;53(6):1054-61.
2004: Maria Rasch; Christiane Buch; Brian Austin; Wilhelmina J Slierendrecht; Kim S Ekmann; Jens Laurits Larsen; Charlotte Johansen; Kathrin Riedel; Leo Eberl; Michael Givskov; Lone Gram
An inhibitor of bacterial quorum sensing reduces mortalities caused by Vibriosis in rainbow trout (Oncorhynchus mykiss, Walbaum).
Systematic and applied microbiology 2004;27(3):350-9.
2004: Niels Bagge; Martin Schuster; Morten Hentzer; Oana Ciofu; Michael Givskov; Everett Peter Greenberg; Niels Høiby
Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.
Antimicrobial agents and chemotherapy 2004;48(4):1175-87.
2004: Niels Bagge; Morten Hentzer; Jens Bo Andersen; Oana Ciofu; Michael Givskov; Niels Høiby
Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms.
Antimicrobial agents and chemotherapy 2004;48(4):1168-74.
2004: Maurizio Labbate; Shu Yeong Queck; Kai Shyang Koh; Scott A Rice; Michael Givskov; Staffan Kjelleberg
Quorum sensing-controlled biofilm development in Serratia liquefaciens MG1.
Journal of bacteriology 2004;186(3):692-8.
2004: Hong Wu; Zhijun Song; Michael Givskov; Niels Høiby
Effects of quorum-sensing on immunoglobulin G responses in a rat model of chronic lung infection with Pseudomonas aeruginosa.
Microbes and infection / Institut Pasteur 2004;6(1):34-7.
2003: Jeremy S Webb; Michael Givskov; Staffan Kjelleberg
Bacterial biofilms: prokaryotic adventures in multicellularity.
Current opinion in microbiology 2003;6(6):578-85.
2003: Catalina Arevalo-Ferro; Morten Hentzer; Gerold Reil; Angelika Görg; Staffan Kjelleberg; Michael Givskov; Kathrin Riedel; Leo Eberl
Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics.
Environmental microbiology 2003;5(12):1350-69.
2003: Morten Hentzer; Michael Givskov
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections.
The Journal of clinical investigation 2003;112(9):1300-7.
2003: Morten Hentzer; Hong Wu; Jens Bo Andersen; Kathrin Riedel; Thomas Bovbjerg Rasmussen; Niels Bagge; Naresh Kumar; Mark A Schembri; Zhijun Song; Peter Kristoffersen; Mike Manefield; J William Costerton; Søren Molin; Leo Eberl; Peter D Steinberg; Staffan Kjelleberg; Niels Høiby; Michael Givskov
Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors.
The EMBO journal 2003;22(15):3803-15.
2003: Jeremy S Webb; Lyndal S Thompson; Sally James; Timothy S Charlton; Tim Tolker-Nielsen; Birgit Koch; Michael Givskov; Staffan Kjelleberg
Cell death in Pseudomonas aeruginosa biofilm development.
Journal of bacteriology 2003;185(15):4585-92.
2003: Thomas Hjelmgaard; Tobias Persson; Thomas Bovbjerg Rasmussen; Michael Givskov; John Nielsen
Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity.
Bioorganic & medicinal chemistry 2003;11(15):3261-71.
2003: Lars Ravn Flodgaard; Allan B Christensen; Søren Molin; Michael Givskov; Lone Gram
Influence of food preservation parameters and associated microbiota on production rate, profile and stability of acylated homoserine lactones from food-derived Enterobacteriaceae.
International journal of food microbiology 2003;84(2):145-56.
2003: Kathrin Riedel; Daniela Talker-Huiber; Michael Givskov; Helmut Schwab; Leo Eberl
Identification and characterization of a GDSL esterase gene located proximal to the swr quorum-sensing system of Serratia liquefaciens MG1.
Applied and environmental microbiology 2003;69(7):3901-10.
2003: Allan B Christensen; Kathrin Riedel; Leo Eberl; Lars Ravn Flodgaard; Søren Molin; Lone Gram; Michael Givskov
Quorum-sensing-directed protein expression in Serratia proteamaculans B5a.
Microbiology (Reading, England) 2003;149(Pt 2):471-83.
2003: Morten Hentzer; Leo Eberl; John Nielsen; Michael Givskov
Quorum sensing : a novel target for the treatment of biofilm infections.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2003;17(4):241-50.
2003: Jens Bo Andersen; Birgit Koch; Tommy Harder Nielsen; Dan Sørensen; Michael Hansen; Ole Nybroe; Carsten Christophersen; Jan Sørensen; Søren Molin; Michael Givskov
Surface motility in Pseudomonas sp. DSS73 is required for efficient biological containment of the root-pathogenic microfungi Rhizoctonia solani and Pythium ultimum.
Microbiology (Reading, England) 2003;149(Pt 1):37-46.
2002: Anette Steidle; Marie Allesen-Holm; Kathrin Riedel; Gabriele Berg; Michael Givskov; Søren Molin; Leo Eberl
Identification and characterization of an N-acylhomoserine lactone-dependent quorum-sensing system in Pseudomonas putida strain IsoF.
Applied and environmental microbiology 2002;68(12):6371-82.
2002: Niels Bagge; Oana Ciofu; Morten Hentzer; Joan I A Campbell; Michael Givskov; Niels Høiby
Constitutive high expression of chromosomal beta-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD.
Antimicrobial agents and chemotherapy 2002;46(11):3406-11.
2002: Birgit Huber; Kathrin Riedel; Manuela Köthe; Michael Givskov; Søren Molin; Leo Eberl
Genetic analysis of functions involved in the late stages of biofilm development in Burkholderia cepacia H111.
Molecular microbiology 2002;46(2):411-26.
2002: Lone Gram; Lars Ravn; Maria Rasch; Jesper Bartholin Bruhn; Allan B Christensen; Michael Givskov
Food spoilage--interactions between food spoilage bacteria.
International journal of food microbiology 2002;78(1-2):79-97.
2002: Yvonne Agersø; Lars Bogø Jensen; Michael Givskov; Marilyn C Roberts
The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group.
FEMS microbiology letters 2002;214(2):251-6.
2002: Birgit Koch; Tommy Harder Nielsen; Dan Sørensen; Jens Bo Andersen; Carsten Christophersen; Søren Molin; Michael Givskov; Jan Sørensen; Ole Nybroe
Lipopeptide production in Pseudomonas sp. strain DSS73 is regulated by components of sugar beet seed exudate via the Gac two-component regulatory system.
Applied and environmental microbiology 2002;68(9):4509-16.
2002: Tommy Harder Nielsen; Dan Sørensen; C Tobiasen; Jens Bo Andersen; Carsten Christophersen; Michael Givskov; Jan Sørensen
Antibiotic and biosurfactant properties of cyclic lipopeptides produced by fluorescent Pseudomonas spp. from the sugar beet rhizosphere.
Applied and environmental microbiology 2002;68(7):3416-23.
2002: David C Laux; Joy M Corson; Michael Givskov; Morten Hentzer; Annette Møller; Kathleen A Wosencroft; Joan C Olson; Karen A Krogfelt; Joanna B Goldberg; Paul S Cohen
Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA.
Microbiology (Reading, England) 2002;148(Pt 6):1709-23.
2002: Mark A Schembri; Michael Givskov; Per Klemm
An attractive surface: gram-negative bacterial biofilms.
Science's STKE : signal transduction knowledge environment 2002;2002(132):re6.
2002: Martin Bees; P Andresén; Erik Mosekilde; Michael Givskov
Quantitative effects of medium hardness and nutrient availability on the swarming motility of Serratia liquefaciens.
Bulletin of mathematical biology 2002;64(3):565-87.
2002: Mike Manefield; Thomas Bovbjerg Rasmussen; Morten Henzter; Jens Bo Andersen; Peter D Steinberg; Staffan Kjelleberg; Michael Givskov
Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover.
Microbiology (Reading, England) 2002;148(Pt 4):1119-27.
2002: Arne Heydorn; Bjarne K Ersbøll; Junichi Kato; Morten Hentzer; Matthew R Parsek; Tim Tolker-Nielsen; Michael Givskov; Søren Molin
Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression.
Applied and environmental microbiology 2002;68(4):2008-17.
2002: J A Olsen; R Severinsen; Thomas Bovbjerg Rasmussen; Morten Hentzer; Michael Givskov; Jens Nielsen
Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers.
Bioorganic & medicinal chemistry letters 2002;12(3):325-8.
2002: Morten Hentzer; Kathrin Riedel; Thomas Bovbjerg Rasmussen; Arne Heydorn; Jens Bo Andersen; Matthew R Parsek; Scott A Rice; Leo Eberl; Søren Molin; Niels Høiby; Staffan Kjelleberg; Michael Givskov
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.
Microbiology (Reading, England) 2002;148(Pt 1):87-102.
2001: Kathrin Riedel; Morten Hentzer; O Geisenberger; Birgit Huber; Anette Steidle; H Wu; Niels Høiby; Michael Givskov; Søren Molin; Leo Eberl
N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms.
Microbiology (Reading, England) 2001;147(Pt 12):3249-62.
2001: Anette Steidle; K Sigl; Regina Schuhegger; Alexandra Ihring; Michael Schmid; Stephan Gantner; M Stoffels; Kathrin Riedel; Michael Givskov; Anton Hartmann; Christian Langebartels; Leo Eberl
Visualization of N-acylhomoserine lactone-mediated cell-cell communication between bacteria colonizing the tomato rhizosphere.
Applied and environmental microbiology 2001;67(12):5761-70.
2001: Mike Manefield; M Welch; Michael Givskov; George P C Salmond; Staffan Kjelleberg
Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora.
FEMS microbiology letters 2001;205(1):131-8.
2001: Birgit Huber; Kathrin Riedel; Morten Hentzer; Arne Heydorn; Astrid Gotschlich; Michael Givskov; Søren Molin; Leo Eberl
The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility.
Microbiology (Reading, England) 2001;147(Pt 9):2517-28.
2001: Morten Hentzer; Gail M Teitzel; G J Balzer; Arne Heydorn; Søren Molin; Michael Givskov; Matthew R Parsek
Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function.
Journal of bacteriology 2001;183(18):5395-401.
2001: H Wu; Z Song; Michael Givskov; Gerd Doring; Dieter Worlitzsch; Kalai Mathee; Jørgen Rygaard; Niels Høiby
Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection.
Microbiology (Reading, England) 2001;147(Pt 5):1105-13.
2001: Lars Ravn; Allan B Christensen; Søren Molin; Michael Givskov; Lone Gram
Methods for detecting acylated homoserine lactones produced by Gram-negative bacteria and their application in studies of AHL-production kinetics.
Journal of microbiological methods 2001;44(3):239-51.
2001: Kathrin Riedel; T Ohnesorg; K A Krogfelt; T S Hansen; Kenji Omori; Michael Givskov; Leo Eberl
N-acyl-L-homoserine lactone-mediated regulation of the lip secretion system in Serratia liquefaciens MG1.
Journal of bacteriology 2001;183(5):1805-9.
2001: Jens Bo Andersen; Arne Heydorn; Morten Hentzer; Leo Eberl; O Geisenberger; Bjarke Bak Christensen; Søren Molin; Michael Givskov
gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication.
Applied and environmental microbiology 2001;67(2):575-85.
2001: Timothy S Charlton; Michael Givskov; R deNys; Jens Bo Andersen; Morten Hentzer; S Rice; Staffan Kjelleberg
Genetic and chemical tools for investigating signaling processes in biofilms.
Methods in enzymology 2001;336():108-28.
2000: Thomas Bovbjerg Rasmussen; Mike Manefield; Jens Bo Andersen; Leo Eberl; Uffe Anthoni; Carsten Christophersen; Peter D Steinberg; Staffan Kjelleberg; Michael Givskov
How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1.
Microbiology (Reading, England) 2000;146 Pt 12():3237-44.
2000: Timothy S Charlton; Rocky de Nys; Andrew G Netting; Naresh Kumar; Morten Hentzer; Michael Givskov; Staffan Kjelleberg
A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm.
Environmental microbiology 2000;2(5):530-41.
2000: H Wu; Z Song; Morten Hentzer; Jens Bo Andersen; Arne Heydorn; Kalai Mathee; Claus Moser; Leo Eberl; Søren Molin; Niels Høiby; Michael Givskov
Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa.
Microbiology (Reading, England) 2000;146 ( Pt 10)():2481-93.
2000: Arne Heydorn; Bjarne K Ersbøll; Morten Hentzer; Matthew R Parsek; Michael Givskov; Søren Molin
Experimental reproducibility in flow-chamber biofilms.
Microbiology (Reading, England) 2000;146 ( Pt 10)():2409-15.
2000: Arne Heydorn; AT Nielsen; Morten Hentzer; Claus Sternberg; Michael Givskov; Bjarne K Ersbøll; Søren Molin
Quantification of biofilm structures by the novel computer program COMSTAT.
Microbiology (Reading, England) 2000;146 ( Pt 10)():2395-407.
2000: Leo Eberl; Aldo Ammendola; Michael Rothballer; Michael Givskov; Claus Sternberg; Mogens Kilstrup; Karl-Heinz Schleifer; Søren Molin
Inactivation of gltB abolishes expression of the assimilatory nitrate reductase gene (nasB) in Pseudomonas putida KT2442.
Journal of bacteriology 2000;182(12):3368-76.
2000: Tim Tolker-Nielsen; Allan B Christensen; K Holmstrøm; Leo Eberl; Thomas Bovbjerg Rasmussen; Claus Sternberg; Arne Heydorn; Søren Molin; Michael Givskov
Assessment of flhDC mRNA levels in Serratia liquefaciens swarm cells.
Journal of bacteriology 2000;182(10):2680-6.
2000: Karen A Krogfelt; M Hjulgaard; K Sørensen; Paul S Cohen; Michael Givskov
rpoS gene function is a disadvantage for Escherichia coli BJ4 during competitive colonization of the mouse large intestine.
Infection and immunity 2000;68(5):2518-24.
2000: O Geisenberger; Michael Givskov; Kathrin Riedel; Niels Høiby; Burkhard Tümmler; Leo Eberl
Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis.
FEMS microbiology letters 2000;184(2):273-8.
2000: Douglas E Caldwell; Rita R Colwell; S Harayama; Staffan Kjelleberg; Michael Givskov; Søren Molin; AT Nielsen; Arne Heydorn; Tim Tolker-Nielsen; Claus Sternberg; K Nealson; N R Pace; P Rainey; E Stackebrandt; B J Tindall; David A Stahl
Crystal ball: leading scientists in the field of environmental microbiology consider the technical and conceptual developments that they believe will drive innovative research during the first years of the new millennium.
Environmental microbiology 2000;2(1):3-10.
2000: Martin Bees; P Andresén; Erik Mosekilde; Michael Givskov
The interaction of thin-film flow, bacterial swarming and cell differentiation in colonies of Serratia liquefaciens.
Journal of mathematical biology 2000;40(1):27-63.
1999: Søren Molin; Michael Givskov
Application of molecular tools for in situ monitoring of bacterial growth activity.
Environmental microbiology 1999;1(5):383-91.
1999: Matthew T G Holden; S Ram Chhabra; Rocky de Nys; P Stead; N J Bainton; Philip J Hill; Mike Manefield; N Kumar; M Labatte; D England; S Rice; Michael Givskov; George P C Salmond; GS Stewart; Barrie W Bycroft; Staffan Kjelleberg; Paul Williams
Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria.
Molecular microbiology 1999;33(6):1254-66.
1999: Claus Sternberg; Bjarke Bak Christensen; T Johansen; A Toftgaard Nielsen; Jens Bo Andersen; Michael Givskov; Søren Molin
Distribution of bacterial growth activity in flow-chamber biofilms.
Applied and environmental microbiology 1999;65(9):4108-17.
1999: Scott A Rice; Michael Givskov; Peter D Steinberg; Staffan Kjelleberg
Bacterial signals and antagonists: the interaction between bacteria and higher organisms.
Journal of molecular microbiology and biotechnology 1999;1(1):23-31.
1999: Lone Gram; Allan B Christensen; Lars Ravn; Søren Molin; Michael Givskov
Production of acylated homoserine lactones by psychrotrophic members of the Enterobacteriaceae isolated from foods.
Applied and environmental microbiology 1999;65(8):3458-63.
1999: Kalai Mathee; Oana Ciofu; Claus Sternberg; PW Lindum; Joan I A Campbell; P Jensen; A H Johnsen; Michael Givskov; Dennis Ohman; Søren Molin; Niels Høiby; Arsalan Kharazmi
Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.
Microbiology (Reading, England) 1999;145 ( Pt 6)():1349-57.
1999: Leo Eberl; Søren Molin; Michael Givskov
Surface motility of serratia liquefaciens MG1.
Journal of bacteriology 1999;181(6):1703-12.
1999: Mike Manefield; Rocky de Nys; Naresh Kumar; Richard Read; Michael Givskov; Peter D Steinberg; Staffan Kjelleberg
Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein.
Microbiology (Reading, England) 1999;145 ( Pt 2)():283-91.
1999: Bjarke Bak Christensen; Claus Sternberg; Jens Bo Andersen; Robert J Palmer; AT Nielsen; Michael Givskov; Søren Molin
Molecular tools for study of biofilm physiology.
Methods in enzymology 1999;310():20-42.
1998: PW Lindum; Uffe Anthoni; Carsten Christophersen; Leo Eberl; Søren Molin; Michael Givskov
N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1.
Journal of bacteriology 1998;180(23):6384-8.
1998: Aldo Ammendola; O Geisenberger; Jens Bo Andersen; Michael Givskov; Karl-Heinz Schleifer; Leo Eberl
Serratia liquefaciens swarm cells exhibit enhanced resistance to predation by Tetrahymena sp.
FEMS microbiology letters 1998;164(1):69-75.
1998: Bjarke Bak Christensen; Claus Sternberg; Jens Bo Andersen; Leo Eberl; S Moller; Michael Givskov; Søren Molin
Establishment of new genetic traits in a microbial biofilm community.
Applied and environmental microbiology 1998;64(6):2247-55.
1998: Jens Bo Andersen; Claus Sternberg; LK Poulsen; S P Bjorn; Michael Givskov; Søren Molin
New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria.
Applied and environmental microbiology 1998;64(6):2240-6.
1998: S Møller; Claus Sternberg; Jens Bo Andersen; Bjarke Bak Christensen; J L Ramos; Michael Givskov; Søren Molin
In situ gene expression in mixed-culture biofilms: evidence of metabolic interactions between community members.
Applied and environmental microbiology 1998;64(2):721-32.
1998: Michael Givskov; Jörgen Östling; Leo Eberl; PW Lindum; Allan B Christensen; G Christiansen; Søren Molin; Staffan Kjelleberg
Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1.
Journal of bacteriology 1998;180(3):742-5.
1996: Michael Givskov; Rocky de Nys; Mike Manefield; L Gram; R Maximilien; Leo Eberl; Søren Molin; Peter D Steinberg; Staffan Kjelleberg
Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling.
Journal of bacteriology 1996;178(22):6618-22.
1996: Leo Eberl; MK Winson; Claus Sternberg; GS Stewart; G Christiansen; Siri Ram Chhabra; Barrie W Bycroft; P Williams; Søren Molin; Michael Givskov
Involvement of N-acyl-L-hormoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens.
Molecular microbiology 1996;20(1):127-36.
1996: Leo Eberl; G Christiansen; Søren Molin; Michael Givskov
Differentiation of Serratia liquefaciens into swarm cells is controlled by the expression of the flhD master operon.
Journal of bacteriology 1996;178(2):554-9.
1995: L S van Overbeek; Leo Eberl; Michael Givskov; Søren Molin; J D van Elsas
Survival of, and induced stress resistance in, carbon-starved Pseudomonas fluorescens cells residing in soil.
Applied and environmental microbiology 1995;61(12):4202-8.
1995: Michael Givskov; Leo Eberl; G Christiansen; M J Benedik; Søren Molin
Induction of phospholipase- and flagellar synthesis in Serratia liquefaciens is controlled by expression of the flagellar master operon flhD.
Molecular microbiology 1995;15(3):445-54.
1995: C S Kristensen; Leo Eberl; J M Sanchez-Romero; Michael Givskov; Søren Molin; Víctor de Lorenzo
Site-specific deletions of chromosomally located DNA segments with the multimer resolution system of broad-host-range plasmid RP4.
Journal of bacteriology 1995;177(1):52-8.
1994: P Ravn; Michael Givskov; K M Eegholm; Søren M Madsen; L Boe
Observations on the formation of deletions on monomeric and dimeric plasmids in Escherichia coli.
Molecular microbiology 1994;14(2):263-70.
1994: Michael Givskov; Leo Eberl; Søren Molin
Responses to nutrient starvation in Pseudomonas putida KT2442: two-dimensional electrophoretic analysis of starvation- and stress-induced proteins.
Journal of bacteriology 1994;176(16):4816-24.
1994: Leo Eberl; C S Kristensen; Michael Givskov; E Grohmann; M Gerlitz; Helmut Schwab
Analysis of the multimer resolution system encoded by the parCBA operon of broad-host-range plasmid RP4.
Molecular microbiology 1994;12(1):131-41.
1994: Michael Givskov; Leo Eberl; S Møller; LK Poulsen; Søren Molin
Responses to nutrient starvation in Pseudomonas putida KT2442: analysis of general cross-protection, cell shape, and macromolecular content.
Journal of bacteriology 1994;176(1):7-14.
1993: Michael Givskov; Søren Molin
Secretion of Serratia liquefaciens phospholipase from Escherichia coli.
Molecular microbiology 1993;8(2):229-42.
1993: Søren Molin; L Boe; L B Jensen; C S Kristensen; Michael Givskov; J L Ramos; Asim K Bej
Suicidal genetic elements and their use in biological containment of bacteria.
Annual review of microbiology 1993;47():139-66.
1992: Leo Eberl; Michael Givskov; Helmut Schwab
The divergent promoters mediating transcription of the par locus of plasmid RP4 are subject to autoregulation.
Molecular microbiology 1992;6(14):1969-79.
1992: Michael Givskov; Søren Molin
Expression of extracellular phospholipase from Serratia liquefaciens is growth-phase-dependent, catabolite-repressed and regulated by anaerobiosis.
Molecular microbiology 1992;6(10):1363-74.
1988: Michael Givskov; L Olsen; Søren Molin
Cloning and expression in Escherichia coli of the gene for extracellular phospholipase A1 from Serratia liquefaciens.
Journal of bacteriology 1988;170(12):5855-62.
1987: Michael Givskov; P Stougaard; J Light; Søren Molin
Identification and characterization of mutations responsible for a runaway replication phenotype of plasmid R1.
Gene 1987;57(2-3):203-11.