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Charles Glabe

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Emily M Sontag; Zhiqun Tan; Anthony Tomlinson; Judith Frydman; Charles G Glabe; David E Housman; Lukasz A Joachimiak; Steven G Potkin; Leslie M Thompson
Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.
Cong Liu; James S Nowick; Jiyong Park; Anna Pensalfini; Michael Sawaya; Minglei Zhao; Arnold J Berk; Pin-Nan Cheng; Charles G Glabe; Dawei Gou; Lin Jiang; David Eisenberg
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Pin-Nan Cheng; Charles G Glabe; Ryan Spencer; R Jeremy Woods; James S Nowick
Heterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one.

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2013: Emily M Sontag; Zhiqun Tan; Anthony Tomlinson; Judith Frydman; Charles G Glabe; David E Housman; Lukasz A Joachimiak; Steven G Potkin; Leslie M Thompson
Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):3077-82.
2012: Cong Liu; James S Nowick; Jiyong Park; Anna Pensalfini; Michael Sawaya; Minglei Zhao; Arnold J Berk; Pin-Nan Cheng; Charles G Glabe; Dawei Gou; Lin Jiang; David Eisenberg
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(51):20913-8.
2012: Pin-Nan Cheng; Charles G Glabe; Ryan Spencer; R Jeremy Woods; James S Nowick
Heterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one.
Journal of the American Chemical Society 2012;134(34):14179-84.
2012: Estelle Sontag; Andrew Tran; Guocheng Yang; Namita Agrawal; Rebecca Aron; Steven Finkbeiner; Charles G Glabe; Alice Lau; Gregor P Lotz; J Lawrence Marsh; Paul J Muchowski; Mihaela Necula; Leslie M Thompson
Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(32):11109-19.
2012: Justin M Nussbaum; Klaus Reymann; Raik Rönicke; Stephan Schilling; Antonia Silva; Eric Swanson; Kaycie Tayler; Tanaporn Wangsanut; Brian Wiltgen; Holger Cynis; Hans-Ulrich Demuth; Charles G Glabe; Sigrid Graubner; Asa Hatami; Birgit Hutter-Paier; Wolfgang Jagla; Anca Alexandru; George S Bloom
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.
Nature 2012;485(7400):651-5.
2012: Arthur Laganowsky; Meytal Landau; Cong Liu; Jiyong Park; Anna Pensalfini; Michael Sawaya; Angela B Soriaga; Poh K Teng; Julian P Whitelegge; Minglei Zhao; Duilio Cascio; Charles G Glabe; David Eisenberg
Atomic view of a toxic amyloid small oligomer.
Science (New York, N.Y.) 2012;335(6073):1228-31.
2012: Emanuela Colla; Charles G Glabe; Poul H Jensen; Olga Pletnikova; Juan C Troncoso; Michael K Lee
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(10):3301-5.
2012: John M Ringman; Jennifer L Tomic; Giovanni Coppola; David Elashoff; Karen H Gylys; Charles G Glabe
Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers.
Dementia and geriatric cognitive disorders extra 2012;2(1):652-7.
2012: Maria I Lioudyno; Virginia Liu; Mathias Lösche; Suhail Rasool; Yuri Sokolov; Jessica Wu; Michael T Alkire; Matteo Broccio; Philip R Dennison; Charles G Glabe; J Ashot Kozak; James E Hall
Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance.
PloS one 2012;7(4):e35090.
2012: Viorela Pop; Christa M Studzinski; Adam M Weidner; Nicole C Berchtold; Charles G Glabe; Elizabeth Head; M Paul Murphy; Carl W Cotman
Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines.
Neurobiology of aging 2012;33(1):108-20.
2011: Cristian A Lasagna-Reeves; Charles G Glabe; Rakez Kayed
Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain.
The Journal of biological chemistry 2011;286(25):22122-30.
2011: Yuyan Zhu; Huayan Hou; Kavon Rezai-Zadeh; Brian Giunta; Amanda Ruscin; Carmelina Gemma; Jingji Jin; Natasa Dragicevic; Patrick Bradshaw; Suhail Rasool; Charles G Glabe; Jared Ehrhart; Paula C Bickford; Takashi Mori; Demian Obregon; Terrence Town; Jun Tan
CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(4):1355-65.
2011: Karin M Danzer; Wolfgang P Ruf; Preeti Putcha; Daniel Joyner; Tadafumi Hashimoto; Charles G Glabe; Bradley T Hyman; Pamela J McLean
Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(1):326-36.
2010: J Mario Isas; Volker Luibl; Lincoln V Johnson; Rakez Kayed; Ronald Wetzel; Charles G Glabe; Ralf Langen; Jeannie Chen
Soluble and mature amyloid fibrils in drusen deposits.
Investigative ophthalmology & visual science 2010;51(3):1304-10.
2010: Jessica W Wu; Leonid Breydo; J Mario Isas; Jerome Lee; Yurii G Kuznetsov; Ralf Langen; Charles G Glabe
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation.
The Journal of biological chemistry 2010;285(9):6071-9.
2010: Tatyana Gurlo; Sergey Ryazantsev; Chang-jiang Huang; Michael W Yeh; Howard A Reber; O Joe Hines; Timothy D O'Brien; Charles G Glabe; Peter C Butler
Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.
The American journal of pathology 2010;176(2):861-9.
2010: Rakez Kayed; Isabel Canto; Leonid Breydo; Suhail Rasool; Tamas Lukacsovich; Jessica Wu; Ricardo Albay; Anna Pensalfini; Stephen Yeung; Elizabeth Head; J Lawrence Marsh; Charles G Glabe
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers.
Molecular neurodegeneration 2010;5():57.
2010: Elizabeth Head; Viorela Pop; Floyd Sarsoza; Rakez Kayed; Tina L Beckett; Christa M Studzinski; Jennifer L Tomic; Charles G Glabe; M Paul Murphy
Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines.
Journal of Alzheimer's disease : JAD 2010;20(2):637-46.
2009: Bingqian Liu; Suhail Rasool; Zhikuan Yang; Charles G Glabe; Steven S Schreiber; Jian Ge; Zhiqun Tan
Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice.
The American journal of pathology 2009;175(5):2099-110.
2009: Floyd Sarsoza; Tommy Saing; Rakez Kayed; Robert Dahlin; Malcolm Dick; Camille Broadwater-Hollifield; Scott Mobley; Ira T Lott; Eric Doran; Daniel Gillen; Clifford Anderson-Bergman; David H Cribbs; Charles G Glabe; Elizabeth Head
A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain.
Acta neuropathologica 2009;118(4):505-17.
2009: Jennifer L Tomic; Anna Pensalfini; Elizabeth Head; Charles G Glabe
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction.
Neurobiology of disease 2009;35(3):352-8.
2009: Erene W Mina; Cristian Lasagna-Reeves; Charles G Glabe; Rakez Kayed
Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro.
Journal of molecular biology 2009;391(3):577-85.
2009: Atul Deshpande; Hideki Kawai; Raju Metherate; Charles G Glabe; Jorge Busciglio
A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(13):4004-15.
2009: Rakez Kayed; Anna Pensalfini; Larry Margol; Yuri Sokolov; Floyd Sarsoza; Elizabeth Head; James E Hall; Charles G Glabe
Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer.
The Journal of biological chemistry 2009;284(7):4230-7.
2009: Hideko Kokubo; Rakez Kayed; Charles G Glabe; Matthias Staufenbiel; Takaomi C Saido; Nobuhisa Iwata; Haruyasu Yamaguchi
Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification.
International journal of Alzheimer's disease 2009;2009():.
2008: Charles G Glabe
Structural classification of toxic amyloid oligomers.
The Journal of biological chemistry 2008;283(44):29639-43.
2008: Michael Bacher; Richard Dodel; Bayan Aljabari; Kathy Keyvani; Philippe Marambaud; Rakez Kayed; Charles G Glabe; Nicole Goertz; Anne Hoppmann; Norbert Sachser; Jens Klotsche; Susanne Schnell; Lars Lewejohann; Yousef Al-Abed
CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease.
The Journal of experimental medicine 2008;205(7):1593-9.
2008: Marcus Kostka; Tobias Högen; Karin M Danzer; Johannes Levin; Matthias Habeck; Andreas Wirth; Richard Wagner; Charles G Glabe; Sabine Finger; Udo Heinzelmann; Patrick Garidel; WENZHEN DUAN; Christopher A Ross; Hans A Kretzschmar; Armin Giese
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.
The Journal of biological chemistry 2008;283(16):10992-1003.
2008: Elizabeth Head; Viorela Pop; Vitaly Vasilevko; MaryAnn Hill; Tommy Saing; Floyd Sarsoza; Michaela Nistor; Lori-Ann Christie; Saskia Milton; Charles G Glabe; Edward Barrett; David H Cribbs
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(14):3555-66.
2008: Thuzar M Shin; J Mario Isas; Chia-Ling Hsieh; Rakez Kayed; Charles G Glabe; Ralf Langen; Jeannie Chen
Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin.
Molecular neurodegeneration 2008;3():16.
2008: Kathryn E Nichol; Wayne W Poon; Anna I Parachikova; David H Cribbs; Charles G Glabe; Carl W Cotman
Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid.
Journal of neuroinflammation 2008;5():13.
2007: Gregory Mamikonyan; Mihaela Necula; Mkrtichyan Mikayel; Anahit Ghochikyan; Irina Petrushina; Nina Movsesyan; Erene Mina; Anatoly Kiyatkin; Charles G Glabe; David H Cribbs; Michael G Agadjanyan
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
The Journal of biological chemistry 2007;282(31):22376-86.
2007: Mihaela Necula; Leonid Breydo; Saskia Milton; Rakez Kayed; Wytze E van der Veer; Paul Tone; Charles G Glabe
Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.
Biochemistry 2007;46(30):8850-60.
2007: Chia-Yu Lin; Tatyana Gurlo; Rakez Kayed; Alexandra E Butler; Leena Haataja; Charles G Glabe; Peter C Butler
Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice.
Diabetes 2007;56(5):1324-32.
2007: Mihaela Necula; Rakez Kayed; Saskia Milton; Charles G Glabe
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
The Journal of biological chemistry 2007;282(14):10311-24.
2007: Alina Maloyan; James Gulick; Charles G Glabe; Rakez Kayed; Jeffrey Robbins
Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5995-6000.
2007: Yuji Yoshiike; Rakez Kayed; Saskia Milton; Akihiko Takashima; Charles G Glabe
Pore-forming proteins share structural and functional homology with amyloid oligomers.
Neuromolecular medicine 2007;9(3):270-5.
2007: Rakez Kayed; Elizabeth Head; Floyd Sarsoza; Tommy Saing; Carl W Cotman; Mihaela Necula; Lawrence Margol; Jessica Wu; Leonid Breydo; Jennifer L Thompson; Suhail Rasool; Tatyana Gurlo; Peter Butler; Charles G Glabe
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.
Molecular neurodegeneration 2007;2():18.
2006: Yuri Sokolov; J Ashot Kozak; Rakez Kayed; Alexandr Chanturiya; Charles G Glabe; James E Hall
Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure.
The Journal of general physiology 2006;128(6):637-47.
2006: Juris J Meier; Rakez Kayed; Chia-Yu Lin; Tatyana Gurlo; Leena Haataja; Sajith A Jayasinghe; Ralf Langen; Charles G Glabe; Peter C Butler
Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.
American journal of physiology. Endocrinology and metabolism 2006;291(6):E1317-24.
2006: Michelle E King; Ho-Man Kan; Peter W Baas; Alev Erisir; Charles G Glabe; George S Bloom
Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid.
The Journal of cell biology 2006;175(4):541-6.
2006: Charles G Glabe
Biomedicine. Avoiding collateral damage in Alzheimer's disease treatment.
Science (New York, N.Y.) 2006;314(5799):602-3.
2006: Yun-Ru Chen; Charles G Glabe
Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.
The Journal of biological chemistry 2006;281(34):24414-22.
2006: Young Hae Chong; Yoo Jung Shin; Eun Ok Lee; Rakez Kayed; Charles G Glabe; Andrea J Tenner
ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.
The Journal of biological chemistry 2006;281(29):20315-25.
2006: Atul Deshpande; Erene Mina; Charles G Glabe; Jorge Busciglio
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(22):6011-8.
2006: Charles G Glabe
Common mechanisms of amyloid oligomer pathogenesis in degenerative disease.
Neurobiology of aging 2006;27(4):570-5.
2006: Sylvain Lesné; Ming Teng Koh; Linda Kotilinek; Rakez Kayed; Charles G Glabe; Austin Yang; Michela Gallagher; Karen K. Hsiao Ashe
A specific amyloid-beta protein assembly in the brain impairs memory.
Nature 2006;440(7082):352-7.
2006: qiulan ma; Giselle P Lim; Marni E Harris-White; Fusheng Yang; Surendra S Ambegaokar; Oliver J Ubeda; Charles G Glabe; Bruce Teter; Sally A Frautschy; Gregory M. Cole
Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.
Journal of neuroscience research 2006;83(3):374-84.
2006: Volker Luibl; J Mario Isas; Rakez Kayed; Charles G Glabe; Ralf Langen; Jeannie Chen
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.
The Journal of clinical investigation 2006;116(2):378-85.
2006: Charles G Glabe; Rakez Kayed
Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis.
Neurology 2006;66(2 Suppl 1):S74-8.
2006: Salvatore Oddo; Antonella Caccamo; Levina Tran; Mary P Lambert; Charles G Glabe; William L Klein; Frank M LaFerla
Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology.
The Journal of biological chemistry 2006;281(3):1599-604.
2006: Rakez Kayed; Charles G Glabe
Conformation-dependent anti-amyloid oligomer antibodies.
Methods in enzymology 2006;413():326-44.
2005: Sylvain Lesné; Carine Ali; Cecília Gabriel; Nicole Croci; Eric T MacKenzie; Charles G Glabe; Michel Plotkine; Catherine Marchand-Verrecchia; Denis Vivien; Alain Buisson
NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(41):9367-77.
2005: Atsushi Sanbe; Hanna Osinska; Chet Villa; James Gulick; Raisa Klevitsky; Charles G Glabe; Rakez Kayed; Jeffrey Robbins
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13592-7.
2005: Hideko Kokubo; Rakez Kayed; Charles G Glabe; Takaomi C Saido; Nobuhisa Iwata; J Bernd Helms; Haruyasu Yamaguchi
Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.
Brain research 2005;1045(1-2):224-8.
2005: Angelo Demuro; Erene Mina; Rakez Kayed; Saskia Milton; Ian Parker; Charles G Glabe
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.
The Journal of biological chemistry 2005;280(17):17294-300.
2005: Fusheng Yang; Giselle P Lim; Aynun N Begum; Oliver J Ubeda; Mychica R Simmons; Surendra S Ambegaokar; Pingping P Chen; Rakez Kayed; Charles G Glabe; Sally A Frautschy; Gregory M. Cole
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
The Journal of biological chemistry 2005;280(7):5892-901.
2005: Hideko Kokubo; Rakez Kayed; Charles G Glabe; Haruyasu Yamaguchi
Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain.
Brain research 2005;1031(2):222-8.
2005: George S Bloom; Ke Ren; Charles G Glabe
Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid.
Biochimica et biophysica acta 2005;1739(2-3):116-24.
2005: Jun Zhou; Maria I Fonseca; Rakez Kayed; Irma Hernandez; Scott D Webster; Ozkan Yazan; David H Cribbs; Charles G Glabe; Andrea J Tenner
Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.
Journal of neuroinflammation 2005;2():28.
2004: Rakez Kayed; Yuri Sokolov; Brian Edmonds; Theresa M McIntire; Saskia Milton; James E Hall; Charles G Glabe
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases.
The Journal of biological chemistry 2004;279(45):46363-6.
2004: Charles G Glabe
Conformation-dependent antibodies target diseases of protein misfolding.
Trends in biochemical sciences 2004;29(10):542-7.
2004: Atsushi Sanbe; Hanna Osinska; Jeffrey E Saffitz; Charles G Glabe; Rakez Kayed; Alina Maloyan; Jeffrey Robbins
Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10132-6.
2004: Qinghai Zhang; Evan T Powers; Jorge Nieva; Mary E Huff; Maria A Dendle; Jan Bieschke; Charles G Glabe; Albert Eschenmoser; Paul Wentworth; Richard A Lerner; Jeffery W Kelly
Metabolite-initiated protein misfolding may trigger Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):4752-7.
2003: Noriko Kamei; Charles G Glabe
The species-specific egg receptor for sea urchin sperm adhesion is EBR1,a novel ADAMTS protein.
Genes & development 2003;17(20):2502-7.
2003: Rakez Kayed; Elizabeth Head; Jennifer L Thompson; Theresa M McIntire; Saskia Milton; Carl W Cotman; Charles G Glabe
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.
Science (New York, N.Y.) 2003;300(5618):486-9.
2003: Joshua C Yoburn; Wenqiang Tian; Justin O Brower; James S Nowick; Charles G Glabe; David L Van Vranken
Dityrosine cross-linked Abeta peptides: fibrillar beta-structure in Abeta(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Abeta(8-14) does not induce beta-structure.
Chemical research in toxicology 2003;16(4):531-5.
2002: Marianna Török; Saskia Milton; Rakez Kayed; Peng Wu; Theresa M McIntire; Charles G Glabe; Ralf Langen
Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.
The Journal of biological chemistry 2002;277(43):40810-5.
2002: Brian A Soreghan; Christian J Pike; Rakez Kayed; Wenquiang Tian; Saskia Milton; Carl W Cotman; Charles G Glabe
The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties.
Neuromolecular medicine 2002;1(1):81-94.
2001: Charles G Glabe
Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease.
Journal of molecular neuroscience : MN 2001;17(2):137-45.
2001: Elizabeth Head; W Garzon-Rodriguez; J K Johnson; Ira T Lott; Carl W Cotman; Charles G Glabe
Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome.
Neurobiology of disease 2001;8(5):792-806.
2001: Scott D Webster; Manuel Galvan; Erick Ferran; W Garzon-Rodriguez; Charles G Glabe; Andrea J Tenner
Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7496-503.
2000: Noriko Kamei; W J Swanson; Charles G Glabe
A rapidly diverging EGF protein regulates species-specific signal transduction in early sea urchin development.
Developmental biology 2000;225(2):267-76.
2000: W Garzon-Rodriguez; A Vega; Marisa Sepulveda-Becerra; Saskia Milton; D A Johnson; A K Yatsimirsky; Charles G Glabe
A conformation change in the carboxyl terminus of Alzheimer's Abeta (1-40) accompanies the transition from dimer to fibril as revealed by fluorescence quenching analysis.
The Journal of biological chemistry 2000;275(30):22645-9.
2000: Noriko Kamei; Charles G Glabe
Subtractive analysis of S. franciscanus and S. purpuratus ovary mRNA: what kinds of genes determine species-specificity?
Zygote (Cambridge, England) 2000;8 Suppl 1():S64.
2000: Scott D Webster; Austin Yang; Lawrence Margol; W Garzon-Rodriguez; Charles G Glabe; Andrea J Tenner
Complement component C1q modulates the phagocytosis of Abeta by microglia.
Experimental neurology 2000;161(1):127-38.
1999: W Garzon-Rodriguez; A K Yatsimirsky; Charles G Glabe
Binding of Zn(II), Cu(II), and Fe(II) ions to Alzheimer's A beta peptide studied by fluorescence.
Bioorganic & medicinal chemistry letters 1999;9(15):2243-8.
1999: Austin Yang; D Chandswangbhuvana; T Shu; A Henschen; Charles G Glabe
Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42.
The Journal of biological chemistry 1999;274(29):20650-6.
1998: W L Bunnell; H V Pham; Charles G Glabe
gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein.
The Journal of biological chemistry 1998;273(48):31947-55.
1998: Ben A Bahr; KB Hoffman; Austin Yang; U S Hess; Charles G Glabe; Gary Lynch
Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein.
The Journal of comparative neurology 1998;397(1):139-47.
1998: Austin Yang; D Chandswangbhuvana; Lawrence Margol; Charles G Glabe
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis.
Journal of neuroscience research 1998;52(6):691-8.
1997: David H Cribbs; Peter Velazquez; Brian A Soreghan; Charles G Glabe; Andrea J Tenner
Complement activation by cross-linked truncated and chimeric full-length beta-amyloid.
Neuroreport 1997;8(16):3457-62.
1997: LP Choo-Smith; W Garzon-Rodriguez; Charles G Glabe; Witold K Surewicz
Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles.
The Journal of biological chemistry 1997;272(37):22987-90.
1997: W Garzon-Rodriguez; Marisa Sepulveda-Becerra; Saskia Milton; Charles G Glabe
Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrations.
The Journal of biological chemistry 1997;272(34):21037-44.
1997: R Mauk; D Jaworski; Noriko Kamei; Charles G Glabe
Identification of a 97-kDa heat shock protein from S. franciscanus ovaries with 94% amino acid identity to the S. purpuratus egg surface receptor for sperm.
Developmental biology 1997;184(1):31-7.
1997: D Burdick; J Kosmoski; Mary Knauer; Charles G Glabe
Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells.
Brain research 1997;746(1-2):275-84.
1997: L L Weber; Malcolm Leissring; Austin Yang; Charles G Glabe; David H Cribbs; Frank M LaFerla
Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques.
Experimental neurology 1997;143(1):37-44.
1996: Mary Knauer; R A Orlando; Charles G Glabe
Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).
Brain research 1996;740(1-2):6-14.
1995: A R Korotzer; J Watt; David H Cribbs; Andrea J Tenner; D Burdick; Charles G Glabe; Carl W Cotman
Cultured rat microglia express C1q and receptor for C1q: implications for amyloid effects on microglia.
Experimental neurology 1995;134(2):214-21.
1995: Austin Yang; Mary Knauer; D A Burdick; Charles G Glabe
Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.
The Journal of biological chemistry 1995;270(24):14786-92.
1995: Christian J Pike; A J Walencewicz-Wasserman; J Kosmoski; David H Cribbs; Charles G Glabe; Carl W Cotman
Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity.
Journal of neurochemistry 1995;64(1):253-65.
1994: B Soreghan; J Kosmoski; Charles G Glabe
Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation.
The Journal of biological chemistry 1994;269(46):28551-4.
1994: H Jiang; D Burdick; Charles G Glabe; Carl W Cotman; Andrea J Tenner
beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):5050-9.
1993: Christian J Pike; D Burdick; A J Walencewicz; Charles G Glabe; Carl W Cotman
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(4):1676-87.
1993: A Lopez; S J Miraglia; Charles G Glabe
Structure/function analysis of the sea urchin sperm adhesive protein bindin.
Developmental biology 1993;156(1):24-33.
1993: S J Miraglia; Charles G Glabe
Characterization of the membrane-associating domain of the sperm adhesive protein, bindin.
Biochimica et biophysica acta 1993;1145(2):191-8.
1992: Mary Knauer; B Soreghan; D Burdick; J Kosmoski; Charles G Glabe
Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7437-41.
1992: D Burdick; B Soreghan; M Kwon; J Kosmoski; Mary Knauer; A Henschen; J Yates; Carl W Cotman; Charles G Glabe
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
The Journal of biological chemistry 1992;267(1):546-54.
1991: Christian J Pike; A J Walencewicz; Charles G Glabe; Carl W Cotman
In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity.
Brain research 1991;563(1-2):311-4.
1991: Christian J Pike; A J Walencewicz; Charles G Glabe; Carl W Cotman
Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures.
European journal of pharmacology 1991;207(4):367-8.
1991: J D Bain; E S Diala; Charles G Glabe; D A Wacker; M H Lyttle; Thomas A Dix; A Richard Chamberlin
Site-specific incorporation of nonnatural residues during in vitro protein biosynthesis with semisynthetic aminoacyl-tRNAs.
Biochemistry 1991;30(22):5411-21.
1991: Charles G Glabe; D Clark
The sequence of the Arbacia punctulata bindin cDNA and implications for the structural basis of species-specific sperm adhesion and fertilization.
Developmental biology 1991;143(2):282-8.
1990: P L DeAngelis; Charles G Glabe
Zinc specifically stimulates the selective binding of a peptide analog of bindin to sulfated fucans.
Peptide research 1990;3(2):62-8.
1990: P L DeAngelis; Charles G Glabe
Specific recognition of sulfate esters by bindin, a sperm adhesion protein from sea urchins.
Biochimica et biophysica acta 1990;1037(1):100-5.
1989: L Kennedy; P L DeAngelis; Charles G Glabe
Analysis of the membrane-interacting domain of the sea urchin sperm adhesive protein bindin.
Biochemistry 1989;28(23):9153-8.
1988: P L DeAngelis; Charles G Glabe
Role of basic amino acids in the interaction of bindin with sulfated fucans.
Biochemistry 1988;27(21):8189-94.
1987: P L DeAngelis; Charles G Glabe
Polysaccharide structural features that are critical for the binding of sulfated fucans to bindin, the adhesive protein from sea urchin sperm.
The Journal of biological chemistry 1987;262(29):13946-52.