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Christopher Glass

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Kaoru Saijo; Andrea Crotti; Christopher K Glass
Regulation of microglia activation and deactivation by nuclear receptors.
Robert Mansson; Mikael Sigvardsson; Eva Welinder; Josefine Åhsberg; Christopher Benner; Christopher K Glass; Yin C Lin; Joseph S Lucas; Cornelis Murre
Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate.
Yin C Lin; Robert Mansson; Kazuko Miyazaki; Masaki Miyazaki; Christopher Benner; Claudia Bossen; Vivek Chandra; Christopher K Glass; Sven Heinz; Cornelis Murre
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.

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All Publications

2013: Kaoru Saijo; Andrea Crotti; Christopher K Glass
Regulation of microglia activation and deactivation by nuclear receptors.
Glia 2013;61(1):104-11.
2012: Robert Mansson; Mikael Sigvardsson; Eva Welinder; Josefine Åhsberg; Christopher Benner; Christopher K Glass; Yin C Lin; Joseph S Lucas; Cornelis Murre
Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(51):21028-33.
2012: Yin C Lin; Robert Mansson; Kazuko Miyazaki; Masaki Miyazaki; Christopher Benner; Claudia Bossen; Vivek Chandra; Christopher K Glass; Sven Heinz; Cornelis Murre
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.
Nature immunology 2012;13(12):1196-204.
2012: QiDong Hu; Wenbo Li; Kenneth A Ohgi; David W Rose; Bogdan Tanasa; Michele Trabucchi; Jie Zhang; Christopher K Glass; Michael G Rosenfeld
DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation.
Nature structural & molecular biology 2012;19(11):1168-75.
2012: Joshua D Stender; Michael Boutros; Kevin Do; Minna U Kaikkonen; Wen Liu; Gabriel Pascual; Norbert Perrimon; Michael G Rosenfeld; Nathanael J Spann; Christopher K Glass
Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.
Molecular cell 2012;48(1):28-38.
2012: Nathanael J Spann; Shankar Subramaniam; M Cameron Sullards; Sotirios Tsimikas; Elaine W Wang; H Alex Brown; Edward A Dennis; Eoin Fahy; Jesse N Fox; Lana X Garmire; Daniel Heudobler; Samuel L Kelly; Klaus Ley; Andrew C Li; Jeffrey G McDonald; Alfred H Merrill; Stephen B Milne; Robert C Murphy; David S Myers; Oswald Quehenberger; Christian R H Raetz; Donna Reichart; David W Russell; Iftach Shaked; Norihito Shibata; Christopher K Glass
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
Cell 2012;151(1):138-52.
2012: Tatiana Kisseleva; Thomas Moore-Morris; Yonghan Paik; David Scholten; Brian Scott; Hidekazu Tsukamoto; Min Cong; Wolfgang Dillmann; Sylvia M Evans; Christopher K Glass; Keiko Iwaisako; Chunyan Jiang; Chris Benner; David A Brenner
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9448-53.
2012: Han Cho; Ling-Wa Chong; Luciano DiTacchio; Michael Downes; Christopher K Glass; Megumi Hatori; Michael T Lam; Christopher Liddle; Satchidananda Panda; Ruth T Yu; Xuan Zhao; Annette R Atkins; Johan Auwerx; Grant D Barish; Ronald M Evans
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β.
Nature 2012;485(7396):123-7.
2012: Christopher K Glass; Jerrold M Olefsky
Inflammation and lipid signaling in the etiology of insulin resistance.
Cell metabolism 2012;15(5):635-45.
2012: M Dafne Cardamone; Christopher K Glass; Anna Krones; Kenneth A Ohgi; Laura Ricci; Michael G Rosenfeld; Bogdan Tanasa; Havilah Taylor; Valentina Perissi
A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.
Molecular cell 2012;46(1):91-104.
2012: Sven Heinz; Christopher K Glass
Roles of lineage-determining transcription factors in establishing open chromatin: lessons from high-throughput studies.
Current topics in microbiology and immunology 2012;356():1-15.
2011: Kaoru Saijo; Christopher K Glass
Microglial cell origin and phenotypes in health and disease.
Nature reviews. Immunology 2011;11(11):775-87.
2011: Gregory S Harmon; Michael T Lam; Christopher K Glass
PPARs and lipid ligands in inflammation and metabolism.
Chemical reviews 2011;111(10):6321-40.
2011: Tatiana Kisseleva; Mitchell Kronenberg; Shauna M McGillvray; Victor Nizet; Donna Reichart; Maren von Köckritz-Blickwede; Gerhard Wingender; Christopher K Glass; David A Brenner
Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.
Journal of molecular medicine (Berlin, Germany) 2011;89(10):997-1013.
2011: Elinore M Mercer; Mikael Sigvardsson; Christopher Benner; Janusz Dutkowski; Martha Flores; Christopher K Glass; Trey Ideker; Suchit Jhunjhunwala; Yin C Lin; Cornelis Murre
Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors.
Immunity 2011;35(3):413-25.
2011: Paul C Norris; Donna Reichart; Darren S Dumlao; Christopher K Glass; Edward A Dennis
Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype.
Journal of leukocyte biology 2011;90(3):563-74.
2011: David Scholten; Jens Lindert; Yong Han Paik; Donna Reichart; Jahar Bhattacharya; David A Brenner; Christopher K Glass; Tatiana Kisseleva
Migration of fibrocytes in fibrogenic liver injury.
The American journal of pathology 2011;179(1):189-98.
2011: Dong Wang; Yiming Zhou; Chris Benner; Ivan Garcia-Bassets; Christopher K Glass; Minna U Kaikkonen; Wenbo Li; Wen Liu; Kenneth A Ohgi; Jinsong Qiu; Michael G Rosenfeld; Xue Su; Xiang-Dong Fu
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA.
Nature 2011;474(7351):390-4.
2011: Minna U Kaikkonen; Michael T Y Lam; Christopher K Glass
Non-coding RNAs as regulators of gene expression and epigenetics.
Cardiovascular research 2011;90(3):430-40.
2011: Kaoru Saijo; Jana G Collier; Andrew C Li; John A Katzenellenbogen; Christopher K Glass
An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation.
Cell 2011;145(4):584-95.
2011: Wendy Huang; Serena Ghisletti; Kaoru Saijo; Meghal Gandhi; Myriam Aouadi; Greg J Tesz; Dawn X Zhang; Joyee Yao; Michael P Czech; Bruce L Goode; Michael G Rosenfeld; Christopher K Glass
Coronin 2A mediates actin-dependent de-repression of inflammatory response genes.
Nature 2011;470(7334):414-8.
2011: Amy L Sullivan; Christopher Benner; Sven Heinz; Wendy Huang; Lan Xie; Joseph M Miano; Christopher K Glass
Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages.
Molecular and cellular biology 2011;31(4):861-75.
2011: Lana X Garmire; Christopher K Glass; Wendy Huang; David G Garmire; Joyee Yao; Shankar Subramaniam
A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages.
PloS one 2011;6(9):e24051.
2011: Xiangting Wang; Xiaoyuan Song; Christopher K Glass; Michael G Rosenfeld
The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs.
Cold Spring Harbor perspectives in biology 2011;3(1):a003756.
2010: Edward A Dennis; Raymond A Deems; Richard Harkewicz; Oswald Quehenberger; H Alex Brown; Stephen B Milne; David S Myers; Christopher K Glass; Gary Hardiman; Donna Reichart; Alfred H Merrill; M Cameron Sullards; Elaine Wang; Robert C Murphy; Christian R H Raetz; Teresa A Garrett; Ziqiang Guan; Andrea C Ryan; David W Russell; Jeffrey G McDonald; Bonne M Thompson; Walter A Shaw; Manish Sud; Yihua Zhao; Shakti Gupta; Mano R Maurya; Eoin Fahy; Shankar Subramaniam
A mouse macrophage lipidome.
The Journal of biological chemistry 2010;285(51):39976-85.
2010: Wuqiang Fan; Hidetaka Morinaga; Jane J Kim; Eunju Bae; Nathanael J Spann; Sven Heinz; Christopher K Glass; Jerrold M Olefsky
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages.
The EMBO journal 2010;29(24):4223-36.
2010: Ohn A Chow; Maren von Köckritz-Blickwede; A Taylor Bright; Mary E Hensler; Annelies S Zinkernagel; Anna L Cogen; Richard L Gallo; Marc Monestier; Yanming Wang; Christopher K Glass; Victor Nizet
Statins enhance formation of phagocyte extracellular traps.
Cell host & microbe 2010;8(5):445-54.
2010: Norihito Shibata; Christopher K Glass
Macrophages, oxysterols and atherosclerosis.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(10):2045-51.
2010: Wendy Huang; Christopher K Glass
Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(8):1542-9.
2010: Wen Liu; Bogdan Tanasa; Oksana V Tyurina; Tian Yuan Zhou; Reto Gassmann; Wei-Ting Liu; Kenneth A Ohgi; Chris Benner; Ivan Garcia-Bassets; Aneel K Aggarwal; Arshad Desai; Pieter C Dorrestein; Christopher K Glass; Michael G Rosenfeld
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
Nature 2010;466(7305):508-12.
2010: Philipp Wiesner; Soo-Ho Choi; Felicidad Almazan; Christopher Benner; Wendy Huang; Cody J Diehl; Ayelet Gonen; Susan Butler; Joseph L Witztum; Christopher K Glass; Yury I Miller
Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia.
Circulation research 2010;107(1):56-65.
2010: Yin C Lin; Suchit Jhunjhunwala; Christopher Benner; Sven Heinz; Eva Welinder; Robert Mansson; Mikael Sigvardsson; James Hagman; Celso A Espinoza; Janusz Dutkowski; Trey Ideker; Christopher K Glass; Cornelis Murre
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.
Nature immunology 2010;11(7):635-43.
2010: Pavan Kadandale; Joshua D Stender; Christopher K Glass; Amy A Kiger
Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10502-7.
2010: Vanessa Núñez; Daniel Alameda; Daniel Rico; Rubén Mota; Pilar Gonzalo; Marta Cedenilla; Thierry Fischer; Lisardo Boscá; Christopher K Glass; Alicia G Arroyo; Mercedes Ricote
Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10626-31.
2010: Sven Heinz; Christopher Benner; Nathanael Spann; Eric Bertolino; Yin C Lin; Peter Laslo; Jason Cheng; Cornelis Murre; Harinder Singh; Christopher K Glass
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities.
Molecular cell 2010;38(4):576-89.
2010: Christopher K Glass; Kaoru Saijo; Beate Winner; Maria Carolina Marchetto; Fred H Gage
Mechanisms underlying inflammation in neurodegeneration.
Cell 2010;140(6):918-34.
2010: Gregory S Harmon; Darren S Dumlao; Damian T Ng; Kim E Barrett; Edward A Dennis; Hui Dong; Christopher K Glass
Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice.
Nature medicine 2010;16(3):313-8.
2010: Valentina Perissi; Kristen Jepsen; Christopher K Glass; Michael G Rosenfeld
Deconstructing repression: evolving models of co-repressor action.
Nature reviews. Genetics 2010;11(2):109-23.
2010: Kaoru Saijo; Andrea Crotti; Christopher K Glass
Nuclear receptors, inflammation, and neurodegenerative diseases.
Advances in immunology 2010;106():21-59.
2010: Jerrold M Olefsky; Christopher K Glass
Macrophages, inflammation, and insulin resistance.
Annual review of physiology 2010;72():219-46.
2009: Chunru Lin; Liuqing Yang; Bogdan Tanasa; Kasey R Hutt; Bong-Gun Ju; Kenneth A Ohgi; Jie Zhang; David W Rose; Xiang-Dong Fu; Christopher K Glass; Michael G Rosenfeld
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer.
Cell 2009;139(6):1069-83.
2009: Wendy Huang; Serena Ghisletti; Valentina Perissi; Michael G Rosenfeld; Christopher K Glass
Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.
Molecular cell 2009;35(1):48-57.
2009: Kaoru Saijo; Beate Winner; Christian T Carson; Jana G Collier; Leah Boyer; Michael G Rosenfeld; Fred H Gage; Christopher K Glass
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death.
Cell 2009;137(1):47-59.
2009: Peter J Cook; Bong-Gun Ju; Francesca Telese; Xiangting Wang; Christopher K Glass; Michael G Rosenfeld
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
Nature 2009;458(7238):591-6.
2009: Norihito Shibata; Christopher K Glass
Regulation of macrophage function in inflammation and atherosclerosis.
Journal of lipid research 2009;50 Suppl():S277-81.
2009: Serena Ghisletti; Wendy Huang; Kristen Jepsen; Chris Benner; Gary Hardiman; Michael G Rosenfeld; Christopher K Glass
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.
Genes & development 2009;23(6):681-93.
2008: Esther Y Chao; Justin A Caravella; Mike A Watson; Nino Campobasso; Serena Ghisletti; Andrew N Billin; Cristin Galardi; Ping Wang; Bryan A Laffitte; Marie A Iannone; Bryan Goodwin; Jason A Nichols; Derek J Parks; Eugene Stewart; Robert W Wiethe; Shawn P Williams; Angela Smallwood; Kenneth H Pearce; Christopher K Glass; Timothy M Willson; William J Zuercher; Jon L Collins
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Journal of medicinal chemistry 2008;51(18):5758-65.
2008: Christopher K Glass; Kaoru Saijo
Immunology: Oxysterols hold T cells in check.
Nature 2008;455(7209):40-1.
2008: Daniel Steinberg; Christopher K Glass; Joseph L Witztum
Evidence mandating earlier and more aggressive treatment of hypercholesterolemia.
Circulation 2008;118(6):672-7.
2008: Esperanza Nunez; Young-Soo Kwon; Kasey R Hutt; Qidong Hu; Maria Dafne Cardamone; Kenneth A Ohgi; Ivan Garcia-Bassets; David W Rose; Christopher K Glass; Michael G Rosenfeld; Xiang-Dong Fu
Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules.
Cell 2008;134(1):189.
2008: Valentina Perissi; Claudio Scafoglio; Jie Zhang; Kenneth A Ohgi; David W Rose; Christopher K Glass; Michael G Rosenfeld
TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.
Molecular cell 2008;29(6):755-66.
2008: Esperanza Nunez; Young-Soo Kwon; Kasey R Hutt; Qidong Hu; Maria Dafne Cardamone; Kenneth A Ohgi; Ivan Garcia-Bassets; David W Rose; Christopher K Glass; Michael G Rosenfeld; Xiang-Dong Fu
Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules.
Cell 2008;132(6):996-1010.
2008: Wenlai Zhou; Ping Zhu; Jianxun Wang; Gabriel Pascual; Kenneth A Ohgi; Jean Lozach; Christopher K Glass; Michael G Rosenfeld
Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.
Molecular cell 2008;29(1):69-80.
2007: Andrew C Li; Christopher K Glass
Use of mouse models to evaluate roles of nuclear receptors and their ligands in the pathogenesis and treatment of atherosclerosis.
Current drug targets 2007;8(12):1273-87.
2007: Daniel S Straus; Christopher K Glass
Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms.
Trends in immunology 2007;28(12):551-8.
2007: M T Audrey Nguyen; Svetlana Favelyukis; Anh-Khoi Nguyen; Donna Reichart; Peter A Scott; Alan Jenn; Ru Liu-Bryan; Christopher K Glass; Jaap G Neels; Jerrold M Olefsky
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways.
The Journal of biological chemistry 2007;282(48):35279-92.
2007: Kristen Jepsen; Derek Solum; Tianyuan Zhou; Robert J McEvilly; Hyun-Jung Kim; Christopher K Glass; Ola Hermanson; Michael G Rosenfeld
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.
Nature 2007;450(7168):415-9.
2007: Ping Zhu; Wenlai Zhou; Jianxun Wang; Janusz Puc; Kenneth A Ohgi; Hediye Erdjument-Bromage; Paul Tempst; Christopher K Glass; Michael G Rosenfeld
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.
Molecular cell 2007;27(4):609-21.
2007: Mercedes Ricote; Christopher K Glass
PPARs and molecular mechanisms of transrepression.
Biochimica et biophysica acta 2007;1771(8):926-35.
2007: Victoria Lunyak; Gratien Prefontaine; Esperanza Núñez; Thorsten Cramer; Bong-Gun Ju; Kenneth A Ohgi; Kasey R Hutt; Rosa Roy; Angel García-Díaz; Xiaoyan Zhu; Yun Yung; Lluis Montoliu; Christopher K Glass; Michael G Rosenfeld
Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.
Science (New York, N.Y.) 2007;317(5835):248-51.
2007: Kelly D Hester; Dominique Verhelle; Laure Escoubet-Lozach; Rosa Luna; David W Rose; Christopher K Glass
Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.
Cell cycle (Georgetown, Tex.) 2007;6(13):1594-604.
2007: Andrea L Hevener; Jerrold M Olefsky; Donna Reichart; M T Audrey Nguyen; Gautam Bandyopadyhay; Ho-Yin Leung; Matthew J Watt; Chris Benner; Mark A Febbraio; Anh-Khoi Nguyen; Brian Folian; Shankar Subramaniam; Frank J Gonzalez; Christopher K Glass; Mercedes Ricote
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.
The Journal of clinical investigation 2007;117(6):1658-69.
2007: Jianxun Wang; Kathleen Scully; Xiaoyan Zhu; Ling Cai; Jie Zhang; Gratien Prefontaine; Anna Krones; Kenneth A Ohgi; Ping Zhu; Ivan Garcia-Bassets; Forrest Liu; Havilah Taylor; Jean Lozach; Friederike L Jayes; Kenneth S Korach; Christopher K Glass; Xiang-Dong Fu; Michael G Rosenfeld
Opposing LSD1 complexes function in developmental gene activation and repression programmes.
Nature 2007;446(7138):882-7.
2007: Young-Soo Kwon; Ivan Garcia-Bassets; Kasey R Hutt; Christine S Cheng; Mingjie Jin; Dongyan Liu; Chris Benner; Dong Wang; Zhen Ye; Marina Bibikova; Jian-Bing Fan; Lingxun Duan; Christopher K Glass; Michael G Rosenfeld; Xiang-Dong Fu
Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):4852-7.
2007: Ivan Garcia-Bassets; Young-Soo Kwon; Francesca Telese; Gratien Prefontaine; Kasey R Hutt; Christine S Cheng; Bong-Gun Ju; Kenneth A Ohgi; Jianxun Wang; Laure Escoubet-Lozach; David W Rose; Christopher K Glass; Xiang-Dong Fu; Michael G Rosenfeld
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors.
Cell 2007;128(3):505-18.
2007: Serena Ghisletti; Wendy Huang; Sumito Ogawa; Gabriel Pascual; Mu-En Lin; Timothy M Willson; Michael G Rosenfeld; Christopher K Glass
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.
Molecular cell 2007;25(1):57-70.
2007: Gabriel Pascual; Amy L Sullivan; Sumito Ogawa; Amir Gamliel; Valentina Perissi; Michael G Rosenfeld; Christopher K Glass
Anti-inflammatory and antidiabetic roles of PPARgamma.
Novartis Foundation symposium 2007;286():183-96; discussion 196-203.
2007: Manish Sud; Eoin Fahy; Dawn Cotter; Alex Brown; Edward A Dennis; Christopher K Glass; Alfred H Merrill; Robert C Murphy; Christian R H Raetz; David W Russell; Shankar Subramaniam
LMSD: LIPID MAPS structure database.
Nucleic acids research 2007;35(Database issue):D527-32.
2006: Gabriel Pascual; Christopher K Glass
Nuclear receptors versus inflammation: mechanisms of transrepression.
Trends in endocrinology and metabolism: TEM 2006;17(8):321-7.
2006: Mercedes Ricote; Cynthia S Snyder; Ho-Yin Leung; Ju Chen; Kenneth R Chien; Christopher K Glass
Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells.
Journal of leukocyte biology 2006;80(4):850-61.
2006: Bong-Gun Ju; Victoria Lunyak; Valentina Perissi; Ivan Garcia-Bassets; David W Rose; Christopher K Glass; Michael G Rosenfeld
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.
Science (New York, N.Y.) 2006;312(5781):1798-802.
2006: Michael G Rosenfeld; Victoria Lunyak; Christopher K Glass
Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response.
Genes & development 2006;20(11):1405-28.
2006: Kazuhito Toyo-Oka; Timothy Bowen; Shinji Hirotsune; Zirong Li; Sonia Jain; Sara Ota; Laure Escoubet-Lozach; Laure Escoubet Lozach; Ivan Garcia-Bassets; Ivan Garcia Bassett; Jean Lozach; Michael G Rosenfeld; Christopher K Glass; Robert N Eisenman; Bing Ren; Peter J Hurlin; Anthony Wynshaw-Boris
Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression.
Cancer research 2006;66(11):5565-73.
2006: Christian R H Raetz; Teresa A Garrett; C Michael Reynolds; Walter A Shaw; Jeff D Moore; Dale C Smith; Anthony A Ribeiro; Robert C Murphy; Richard J Ulevitch; Colleen Fearns; Donna Reichart; Christopher K Glass; Chris Benner; Shankar Subramaniam; Richard Harkewicz; Rebecca C Bowers-Gentry; Matthew Buczynski; Jennifer A Cooper; Raymond A Deems; Edward A Dennis
Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4.
Journal of lipid research 2006;47(5):1097-111.
2006: Christopher K Glass
Going nuclear in metabolic and cardiovascular disease.
The Journal of clinical investigation 2006;116(3):556-60.
2006: Ping Zhu; Sung Hee Baek; Eliot M Bourk; Kenneth A Ohgi; Ivan Garcia-Bassets; Hideki Sanjo; Shizuo Akira; Paul F Kotol; Christopher K Glass; Michael G Rosenfeld; David W Rose
Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.
Cell 2006;124(3):615-29.
2006: Kate Liddiard; John S Welch; Jean Lozach; Sven Heinz; Christopher K Glass; David Greaves
Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter.
BMC molecular biology 2006;7():45.
2006: Christopher K Glass; Sumito Ogawa
Combinatorial roles of nuclear receptors in inflammation and immunity.
Nature reviews. Immunology 2006;6(1):44-55.
2005: Gabriel Pascual; Amy L Fong; Sumito Ogawa; Amir Gamliel; Andrew C Li; Valentina Perissi; David W Rose; Timothy M Willson; Michael G Rosenfeld; Christopher K Glass
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
Nature 2005;437(7059):759-63.
2005: Sumito Ogawa; Jean Lozach; Chris Benner; Gabriel Pascual; Rajendra K Tangirala; Stefan Westin; Alexander Hoffmann; Shankar Subramaniam; Michael David; Michael G Rosenfeld; Christopher K Glass
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.
Cell 2005;122(5):707-21.
2005: Gary Bradshaw; Alejandra Gutierrez; Jon H Miyake; Kimberly R Davis; Andrew C Li; Christopher K Glass; Linda K Curtiss; Roger A Davis
Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11029-34.
2005: Tae Hoon Kim; Leah O Barrera; Chunxu Qu; Sara Van Calcar; Nathan D Trinklein; Sara J Cooper; Rosa M Luna; Christopher K Glass; Michael G Rosenfeld; Richard Myers; Bing Ren
Direct isolation and identification of promoters in the human genome.
Genome research 2005;15(6):830-9.
2005: Eoin Fahy; Shankar Subramaniam; H Alex Brown; Christopher K Glass; Alfred H Merrill; Robert C Murphy; Christian R H Raetz; David W Russell; Yousuke Seyama; Walter Shaw; Takao Shimizu; Friedrich Spener; Gerrit van Meer; Michael S VanNieuwenhze; Stephen H White; Joseph L Witztum; Edward A Dennis
A comprehensive classification system for lipids.
Journal of lipid research 2005;46(5):839-61.
2004: Annabel F Valledor; Li-Chung Hsu; Sumito Ogawa; Dominique Sawka-Verhelle; Michael Karin; Christopher K Glass
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17813-8.
2004: Bong-Gun Ju; Derek Solum; Eun Joo Song; Kong-Joo Lee; David W Rose; Christopher K Glass; Michael G Rosenfeld
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Cell 2004;119(6):815-29.
2004: Andrew C Li; Christoph J Binder; Alejandra Gutierrez; Kathleen K Brown; Christine R Plotkin; Jennifer W Pattison; Annabel F Valledor; Roger A Davis; Timothy M Willson; Joseph L Witztum; Wulf Palinski; Christopher K Glass
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma.
The Journal of clinical investigation 2004;114(11):1564-76.
2004: Andrew C Li; Christopher K Glass
PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis.
Journal of lipid research 2004;45(12):2161-73.
2004: Sumito Ogawa; Christopher K Glass
Factor XIIIA (cross)links AT1 receptors to atherosclerosis.
Cell 2004;119(3):313-4.
2004: Sumito Ogawa; Jean Lozach; Kristen Jepsen; Dominique Sawka-Verhelle; Valentina Perissi; Roman Sasik; David W Rose; Randall S Johnson; Michael G Rosenfeld; Christopher K Glass
A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14461-6.
2004: Robyn Cunard; Yoko Eto; Julie T Muljadi; Christopher K Glass; Carolyn J Kelly; Mercedes Ricote
Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7530-6.
2004: Dominique Sawka-Verhelle; Laure Escoubet-Lozach; Amy L Fong; Kelly D Hester; Stephan Herzig; Patricia Lebrun; Christopher K Glass
PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation.
The Journal of biological chemistry 2004;279(17):17772-84.
2004: Christopher K Glass; Donald P McDonnell
The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology.
Molecular cell 2004;13(4):459-67.
2004: Valentina Perissi; Aneel Aggarwal; Christopher K Glass; David W Rose; Michael G Rosenfeld
A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.
Cell 2004;116(4):511-26.
2004: Mercedes Ricote; Annabel F Valledor; Christopher K Glass
Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(2):230-9.
2003: Xue Li; Kenneth A Oghi; Jie Zhang; Anna Krones; Kevin T Bush; Christopher K Glass; Sanjay K Nigam; Aneel K Aggarwal; Richard Maas; David W Rose; Michael G Rosenfeld
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis.
Nature 2003;426(6964):247-54.
2003: Brandee L Wagner; Annabel F Valledor; Gang Shao; Chris L Daige; Eric D Bischoff; Mary Petrowski; Kristen Jepsen; Sung Hee Baek; Richard A Heyman; Michael G Rosenfeld; Ira G Schulman; Christopher K Glass
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.
Molecular and cellular biology 2003;23(16):5780-9.
2003: John S Welch; Mercedes Ricote; Taro E Akiyama; Frank J Gonzalez; Christopher K Glass
PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6712-7.
2003: Sung Hee Baek; Chrissa Kioussi; Paola Briata; Degeng Wang; H D Nguyen; Kenneth A Ohgi; Christopher K Glass; Anthony Wynshaw-Boris; David W Rose; Michael G Rosenfeld
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3245-50.
2002: Robyn Cunard; Dennis DiCampli; D Clay Archer; Jennifer L Stevenson; Mercedes Ricote; Christopher K Glass; Carolyn J Kelly
WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6806-12.
2002: Chrissa Kioussi; Paola Briata; Sung Hee Baek; David W Rose; Natasha S Hamblet; Thomas Herman; Kenneth A Ohgi; Chijen Lin; Anatoli Gleiberman; Jianbo Wang; Véronique Brault; Pilar Ruiz-Lozano; H D Nguyen; Rolf Kemler; Christopher K Glass; Anthony Wynshaw-Boris; Michael G Rosenfeld
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development.
Cell 2002;111(5):673-85.
2002: John S Welch; Laure Escoubet-Lozach; David B Sykes; Kate Liddiard; David Greaves; Christopher K Glass
TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism.
The Journal of biological chemistry 2002;277(45):42821-9.
2002: Andrew C Li; Christopher K Glass
The macrophage foam cell as a target for therapeutic intervention.
Nature medicine 2002;8(11):1235-42.
2002: Laure Escoubet-Lozach; Christopher K Glass; Stephen I Wasserman
The role of transcription factors in allergic inflammation.
The Journal of allergy and clinical immunology 2002;110(4):553-64.
2002: Sung Hee Baek; Kenneth A Ohgi; David W Rose; Edward H Koo; Christopher K Glass; Michael G Rosenfeld
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.
Cell 2002;110(1):55-67.
2002: Günter W Klappacher; Victoria Lunyak; David B Sykes; Dominique Sawka-Verhelle; Julien Sage; Gyan Brard; Sally D Ngo; Denise Gangadharan; Tyler Jacks; Mark P Kamps; David W Rose; Michael G Rosenfeld; Christopher K Glass
An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.
Cell 2002;109(2):169-80.
2002: Taro E Akiyama; Shuichi Sakai; Gilles Lambert; Christopher J Nicol; Kimihiko Matsusue; Satish Pimprale; Ying-Hue Lee; Mercedes Ricote; Christopher K Glass; H Bryan Brewer; Frank J Gonzalez
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.
Molecular and cellular biology 2002;22(8):2607-19.
2002: Claudio Napoli; Filomena de Nigris; John S Welch; Federico B Calara; Robert O Stuart; Christopher K Glass; Wulf Palinski
Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray.
Circulation 2002;105(11):1360-7.
2002: Robyn Cunard; Mercedes Ricote; Dennis DiCampli; D Clay Archer; Daniel A Kahn; Christopher K Glass; Carolyn J Kelly
Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2795-802.
2002: Ola Hermanson; Christopher K Glass; Michael G Rosenfeld
Nuclear receptor coregulators: multiple modes of modification.
Trends in endocrinology and metabolism: TEM 2002;13(2):55-60.
2001: Michael G Rosenfeld; Christopher K Glass
Coregulator codes of transcriptional regulation by nuclear receptors.
The Journal of biological chemistry 2001;276(40):36865-8.
2001: T Murata; R Kurokawa; Anna Krones; K Tatsumi; M Ishii; Tomohiko Taki; M Masuno; H Ohashi; M Yanagisawa; Michael G Rosenfeld; Christopher K Glass; Yasuhide Hayashi
Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome.
Human molecular genetics 2001;10(10):1071-6.
2001: Daniel S Straus; Christopher K Glass
Cyclopentenone prostaglandins: new insights on biological activities and cellular targets.
Medicinal research reviews 2001;21(3):185-210.
2000: Z Wang; David W Rose; Ola Hermanson; F Liu; Thomas Herman; W Wu; DP Szeto; Anatoli Gleiberman; Anna Krones; K Pratt; Ronald G Rosenfeld; Christopher K Glass; Michael G Rosenfeld
Regulation of somatic growth by the p160 coactivator p/CIP.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13549-54.
2000: Kristen Jepsen; Ola Hermanson; Thandi M Onami; Anatoli Gleiberman; Victoria Lunyak; Robert J McEvilly; R Kurokawa; V Kumar; Forrest Liu; E Seto; Stephen M Hedrick; Gail Mandel; Christopher K Glass; David W Rose; Michael G Rosenfeld
Combinatorial roles of the nuclear receptor corepressor in transcription and development.
Cell 2000;102(6):753-63.
2000: Ki Hoon Han; Mi-Kyung Chang; Agnès Boullier; Simone R Green; A Li; Christopher K Glass; Oswald Quehenberger
Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma.
The Journal of clinical investigation 2000;106(6):793-802.
2000: Andrew C Li; K K Brown; MJ Silvestre; Timothy M Willson; Wulf Palinski; Christopher K Glass
Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice.
The Journal of clinical investigation 2000;106(4):523-31.
2000: C J Kim; J C Khoo; K Gillotte-Taylor; A Li; Wulf Palinski; Christopher K Glass; Daniel Steinberg
Polymerase chain reaction-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: enhancement by tumor necrosis factor-alpha and interleukin-1 beta.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(8):1976-82.
2000: M Li; Gabriel Pascual; Christopher K Glass
Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene.
Molecular and cellular biology 2000;20(13):4699-707.
2000: Yu-Der Wen; Valentina Perissi; L M Staszewski; Wen-Ming Yang; Anna Krones; Christopher K Glass; Michael G Rosenfeld; E Seto
The histone deacetylase-3 complex contains nuclear receptor corepressors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7202-7.
2000: Daniel S Straus; G Pascual; M Li; John S Welch; Mercedes Ricote; Chin-Hui Hsiang; Lei Lei Sengchanthalangsy; riya ghosh; Christopher K Glass
15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4844-9.
2000: Juan Llopis; S Westin; Mercedes Ricote; Zuncai Wang; C Y Cho; R Kurokawa; TM Mullen; David W Rose; Michael G Rosenfeld; Roger Y Tsien; Christopher K Glass; J Wang
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4363-8.
2000: Christopher K Glass; Michael G Rosenfeld
The coregulator exchange in transcriptional functions of nuclear receptors.
Genes & development 2000;14(2):121-41.
2000: Mercedes Ricote; John S Welch; Christopher K Glass
Regulation of macrophage gene expression by the peroxisome proliferator-activated receptor-gamma.
Hormone research 2000;54(5-6):275-80.
2000: S Westin; Michael G Rosenfeld; Christopher K Glass
Nuclear receptor coactivators.
Advances in pharmacology (San Diego, Calif.) 2000;47():89-112.
1999: Valentina Perissi; L M Staszewski; EM McInerney; R Kurokawa; Anna Krones; David W Rose; Millard H Lambert; MV Milburn; Christopher K Glass; Michael G Rosenfeld
Molecular determinants of nuclear receptor-corepressor interaction.
Genes & development 1999;13(24):3198-208.
1999: Mercedes Ricote; J T Huang; John S Welch; Christopher K Glass
The peroxisome proliferator-activated receptor(PPARgamma) as a regulator of monocyte/macrophage function.
Journal of leukocyte biology 1999;66(5):733-9.
1999: K A Sheppard; David W Rose; Z K Haque; R Kurokawa; EM McInerney; S Westin; D Thanos; Michael G Rosenfeld; Christopher K Glass; T Collins
Transcriptional activation by NF-kappaB requires multiple coactivators.
Molecular and cellular biology 1999;19(9):6367-78.
1999: Ingolf Bach; Concepcion Rodriguez-Esteban; C Carrière; A Bhushan; Anna Krones; David W Rose; Christopher K Glass; Bogi Andersen; Juan Carlos Izpisúa Belmonte; Michael G Rosenfeld
RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.
Nature genetics 1999;22(4):394-9.
1999: J T Huang; John S Welch; Mercedes Ricote; C J Binder; Timothy M Willson; C Kelly; Joseph L Witztum; Colin D Funk; Douglas J Conrad; Christopher K Glass
Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.
Nature 1999;400(6742):378-82.
1999: Valentina Perissi; Jeremy S Dasen; R Kurokawa; Zuncai Wang; Edward Korzus; David W Rose; Christopher K Glass; Michael G Rosenfeld
Factor-specific modulation of CREB-binding protein acetyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3652-7.
1998: K A Sheppard; K M Phelps; A J Williams; D Thanos; Christopher K Glass; Michael G Rosenfeld; M E Gerritsen; T Collins
Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1.
The Journal of biological chemistry 1998;273(45):29291-4.
1998: EM McInerney; David W Rose; SE Flynn; S Westin; TM Mullen; Anna Krones; J Inostroza; Joseph Torchia; Robert T Nolte; N Assa-Munt; MV Milburn; Christopher K Glass; Michael G Rosenfeld
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation.
Genes & development 1998;12(21):3357-68.
1998: Li Xu; RM Lavinsky; Jeremy S Dasen; SE Flynn; EM McInerney; TM Mullen; T Heinzel; DP Szeto; Edward Korzus; R Kurokawa; Aneel K Aggarwal; David W Rose; Christopher K Glass; Michael G Rosenfeld
Signal-specific co-activator domain requirements for Pit-1 activation.
Nature 1998;395(6699):301-6.
1998: S Westin; R Kurokawa; Robert T Nolte; G Bruce Wisely; EM McInerney; David W Rose; MV Milburn; Michael G Rosenfeld; Christopher K Glass
Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators.
Nature 1998;395(6698):199-202.
1998: Robert T Nolte; G Bruce Wisely; S Westin; Jeffery Cobb; Millard H Lambert; R Kurokawa; Michael G Rosenfeld; Timothy M Willson; Christopher K Glass; MV Milburn
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
Nature 1998;395(6698):137-43.
1998: Carol D Laherty; AN Billin; RM Lavinsky; Gregory S Yochum; A C Bush; J M Sun; TM Mullen; James Davie; David W Rose; Christopher K Glass; Michael G Rosenfeld; Donald E Ayer; Robert N Eisenman
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.
Molecular cell 1998;2(1):33-42.
1998: F Guidez; Andrew C Li; A Horvai; John S Welch; Christopher K Glass
Differential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation.
Molecular and cellular biology 1998;18(7):3851-61.
1998: Mercedes Ricote; J Huang; Lluis Fajas; A Li; J Welch; J Najib; Joseph L Witztum; Johan Auwerx; W Palinski; Christopher K Glass
Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7614-9.
1998: RM Lavinsky; Kristen Jepsen; T Heinzel; Joseph Torchia; TM Mullen; R Schiff; A L Del-Rio; Mercedes Ricote; Sally D Ngo; J Gemsch; S G Hilsenbeck; C Kent Osborne; Christopher K Glass; Michael G Rosenfeld; David W Rose
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2920-5.
1998: Andrew C Li; F R Guidez; J G Collier; Christopher K Glass
The macrosialin promoter directs high levels of transcriptional activity in macrophages dependent on combinatorial interactions between PU.1 and c-Jun.
The Journal of biological chemistry 1998;273(9):5389-99.
1998: Edward Korzus; Joseph Torchia; David W Rose; Li Xu; R Kurokawa; EM McInerney; TM Mullen; Christopher K Glass; Michael G Rosenfeld
Transcription factor-specific requirements for coactivators and their acetyltransferase functions.
Science (New York, N.Y.) 1998;279(5351):703-7.
1998: R Kurokawa; D Kalafus; MH Ogliastro; Chrissa Kioussi; Li Xu; Joseph Torchia; Michael G Rosenfeld; Christopher K Glass
Differential use of CREB binding protein-coactivator complexes.
Science (New York, N.Y.) 1998;279(5351):700-3.
1998: Mercedes Ricote; Andrew C Li; Timothy M Willson; Carolyn J Kelly; Christopher K Glass
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation.
Nature 1998;391(6662):79-82.
1997: Joseph Torchia; David W Rose; J Inostroza; Y Kamei; S Westin; Christopher K Glass; Michael G Rosenfeld
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.
Nature 1997;387(6634):677-84.
1997: M Söderström; A Vo; T Heinzel; RM Lavinsky; Wen-Ming Yang; E Seto; D A Peterson; Michael G Rosenfeld; Christopher K Glass
Differential effects of nuclear receptor corepressor (N-CoR) expression levels on retinoic acid receptor-mediated repression support the existence of dynamically regulated corepressor complexes.
Molecular endocrinology (Baltimore, Md.) 1997;11(6):682-92.
1997: Christopher K Glass; Michael G Rosenfeld; David W Rose; R Kurokawa; Y Kamei; Li Xu; Joseph Torchia; MH Ogliastro; S Westin
Mechanisms of transcriptional activation by retinoic acid receptors.
Biochemical Society transactions 1997;25(2):602-5.
1997: T Heinzel; RM Lavinsky; TM Mullen; M Söderstrom; Carol D Laherty; Joseph Torchia; Wen-Ming Yang; Gyan Brard; Sally D Ngo; James Davie; E Seto; Robert N Eisenman; David W Rose; Christopher K Glass; Michael G Rosenfeld
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
Nature 1997;387(6628):43-8.
1997: J DiRenzo; M Söderstrom; R Kurokawa; MH Ogliastro; Mercedes Ricote; S Ingrey; A Hörlein; Michael G Rosenfeld; Christopher K Glass
Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors.
Molecular and cellular biology 1997;17(4):2166-76.
1997: Christopher K Glass; David W Rose; Michael G Rosenfeld
Nuclear receptor coactivators.
Current opinion in cell biology 1997;9(2):222-32.
1997: A E Horvai; Li Xu; Edward Korzus; Gyan Brard; D Kalafus; TM Mullen; David W Rose; Michael G Rosenfeld; Christopher K Glass
Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1074-9.
1996: I Zamir; H P Harding; G B Atkins; A Hörlein; Christopher K Glass; Michael G Rosenfeld; Mitchell Lazar
A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains.
Molecular and cellular biology 1996;16(10):5458-65.
1996: Steven M Lipkin; T L Grider; R A Heyman; Christopher K Glass; Fred H Gage
Constitutive retinoid receptors expressed from adenovirus vectors that specifically activate chromosomal target genes required for differentiation of promyelocytic leukemia and teratocarcinoma cells.
Journal of virology 1996;70(10):7182-9.
1996: Christopher K Glass
Some new twists in the regulation of gene expression by thyroid hormone and retinoic acid receptors.
The Journal of endocrinology 1996;150(3):349-57.
1996: Y Kamei; Li Xu; T Heinzel; Joseph Torchia; R Kurokawa; B Gloss; S C Lin; Richard A Heyman; David W Rose; Christopher K Glass; Michael G Rosenfeld
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.
Cell 1996;85(3):403-14.
1996: T P Knecht; cynthia behling; D W Burton; Christopher K Glass; Leonard J Deftos
The humoral hypercalcemia of benignancy. A newly appreciated syndrome.
American journal of clinical pathology 1996;105(4):487-92.
1996: V L Jaramillo-Babb; J L Sugarmans; R Scavetta; S J Wang; Norbert Berndt; T L Born; Christopher K Glass; Axel H Schönthal
Positive regulation of cdc2 gene activity by protein phosphatase type 2A.
The Journal of biological chemistry 1996;271(11):5988-92.
1995: R Kurokawa; M Söderström; A Hörlein; Shlomit Halachmi; Myles Brown; Michael G Rosenfeld; Christopher K Glass
Polarity-specific activities of retinoic acid receptors determined by a co-repressor.
Nature 1995;377(6548):451-4.
1995: A J Hörlein; Anders M Näär; T Heinzel; Joseph Torchia; B Gloss; R Kurokawa; A Ryan; Y Kamei; M Söderström; Christopher K Glass
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.
Nature 1995;377(6548):397-404.
1995: T P Knecht; cynthia behling; D W Burton; Christopher K Glass; Leonard J Deftos
Humoral hypercalcaemia of "benignancy".
Lancet 1995;346(8976):711-2.
1995: J M Holloway; DP Szeto; K M Scully; Christopher K Glass; Michael G Rosenfeld
Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain.
Genes & development 1995;9(16):1992-2006.
1995: A Horvai; Wulf Palinski; H Wu; Karen S Moulton; K Kalla; Christopher K Glass
Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5391-5.
1995: J L Sugarman; Axel H Schönthal; Christopher K Glass
Identification of a cell-type-specific and E2F-independent mechanism for repression of cdc2 transcription.
Molecular and cellular biology 1995;15(6):3282-90.
1995: T P Knecht; Christopher K Glass
The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis.
Advances in genetics 1995;32():141-98.
1994: R Kurokawa; J DiRenzo; Marcus F Boehm; J Sugarman; B Gloss; Michael G Rosenfeld; Richard A Heyman; Christopher K Glass
Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding.
Nature 1994;371(6497):528-31.
1994: Karen S Moulton; K Semple; H Wu; Christopher K Glass
Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif.
Molecular and cellular biology 1994;14(7):4408-18.
1994: R Hartong; N Wang; R Kurokawa; Mitchell Lazar; Christopher K Glass; James W Apriletti; Wolfgang H Dillmann
Delineation of three different thyroid hormone-response elements in promoter of rat sarcoplasmic reticulum Ca2+ATPase gene. Demonstration that retinoid X receptor binds 5' to thyroid hormone receptor in response element 1.
The Journal of biological chemistry 1994;269(17):13021-9.
1994: H Wu; Karen S Moulton; A Horvai; S Parik; Christopher K Glass
Combinatorial interactions between AP-1 and ets domain proteins contribute to the developmental regulation of the macrophage scavenger receptor gene.
Molecular and cellular biology 1994;14(3):2129-39.
1993: R Kurokawa; V C Yu; Anders M Näär; Seiko Kyakumoto; Z Han; S Silverman; Michael G Rosenfeld; Christopher K Glass
Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.
Genes & development 1993;7(7B):1423-35.
1993: sergio lira; K A Kalla; Christopher K Glass; D W Drolet; Michael G Rosenfeld
Synergistic interactions between Pit-1 and other elements are required for effective somatotroph rat growth hormone gene expression in transgenic mice.
Molecular endocrinology (Baltimore, Md.) 1993;7(5):694-701.
1992: H Wu; Karen S Moulton; Christopher K Glass
Macrophage scavenger receptors and atherosclerosis.
Trends in cardiovascular medicine 1992;2(6):220-5.
1992: Karen S Moulton; H Wu; J Barnett; Sampath Parthasarathy; Christopher K Glass
Regulated expression of the human acetylated low density lipoprotein receptor gene and isolation of promoter sequences.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8102-6.
1992: Steven M Lipkin; C A Nelson; Christopher K Glass; Michael G Rosenfeld
A negative retinoic acid response element in the rat oxytocin promoter restricts transcriptional stimulation by heterologous transactivation domains.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1209-13.
1992: Steven M Lipkin; Michael G Rosenfeld; Christopher K Glass
Regulation of gene expression by thyroid hormones and retinoic acid.
Genetic engineering 1992;14():185-209.
1991: V C Yu; C Delsert; B Andersen; J M Holloway; O V Devary; Anders M Näär; S Y Kim; J M Boutin; Christopher K Glass; Michael G Rosenfeld
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.
Cell 1991;67(6):1251-66.
1991: Christopher K Glass; J DiRenzo; R Kurokawa; Z H Han
Regulation of gene expression by retinoic acid receptors.
DNA and cell biology 1991;10(9):623-38.
1991: Anders M Näär; J M Boutin; Steven M Lipkin; V C Yu; J M Holloway; Christopher K Glass; Michael G Rosenfeld
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors.
Cell 1991;65(7):1267-79.
1990: Christopher K Glass; J M Holloway
Regulation of gene expression by the thyroid hormone receptor.
Biochimica et biophysica acta 1990;1032(2-3):157-76.
1990: Christopher K Glass; O V Devary; Michael G Rosenfeld
Multiple cell type-specific proteins differentially regulate target sequence recognition by the alpha retinoic acid receptor.
Cell 1990;63(4):729-38.
1990: J M Holloway; Christopher K Glass; S Adler; C A Nelson; Michael G Rosenfeld
The C'-terminal interaction domain of the thyroid hormone receptor confers the ability of the DNA site to dictate positive or negative transcriptional activity.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):8160-4.
1990: L G Hudson; J B Santon; Christopher K Glass; Gordon N Gill
Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression.
Cell 1990;62(6):1165-75.
1990: S Ylä-Herttuala; M E Rosenfeld; Sampath Parthasarathy; Christopher K Glass; E Sigal; Joseph L Witztum; Daniel Steinberg
Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(18):6959-63.
1989: Christopher K Glass; Steven M Lipkin; O V Devary; Michael G Rosenfeld
Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer.
Cell 1989;59(4):697-708.
1988: Christopher K Glass; J M Holloway; O V Devary; Michael G Rosenfeld
The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements.
Cell 1988;54(3):313-23.
1988: sergio lira; E B Crenshaw; Christopher K Glass; L W Swanson; Michael G Rosenfeld
Identification of rat growth hormone genomic sequences targeting pituitary expression in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4755-9.
1988: Michael G Rosenfeld; Christopher K Glass; S Adler; E B Crenshaw; X He; sergio lira; H P Elsholtz; H J Mangalam; J M Holloway; C Nelson
Response and binding elements for ligand-dependent positive transcription factors integrate positive and negative regulation of gene expression.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():545-56.
1987: Christopher K Glass; R Franco; C Weinberger; V R Albert; Ronald M Evans; Michael G Rosenfeld
A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone.
Nature 1987;329(6141):738-41.