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Hansruedi Glatt

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Kristin Herrmann; Kathrin Klein; Fabian Schumacher; Ulrich M Zanger; Klaus E Appel; Wolfram Engst; Hansruedi Glatt
Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples.
Fabian Schumacher; Kristin Herrmann; Wolfram Engst; Simone Florian; Hansruedi Glatt
Optimized enzymatic hydrolysis of DNA for LC-MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol.
Fabian Schumacher; Albrecht Seidel; Lisa Steinhauser; Bernhard H Monien; Anke Schnapper; Klaus Albert; Wolfram Engst; Simone Florian; Heinz Frank; Hansruedi Glatt
Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.

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2013: Kristin Herrmann; Kathrin Klein; Fabian Schumacher; Ulrich M Zanger; Klaus E Appel; Wolfram Engst; Hansruedi Glatt
Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples.
Carcinogenesis 2013;34(5):1025-30.
2013: Fabian Schumacher; Kristin Herrmann; Wolfram Engst; Simone Florian; Hansruedi Glatt
Optimized enzymatic hydrolysis of DNA for LC-MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol.
Analytical biochemistry 2013;434(1):4-11.
2012: Fabian Schumacher; Albrecht Seidel; Lisa Steinhauser; Bernhard H Monien; Anke Schnapper; Klaus Albert; Wolfram Engst; Simone Florian; Heinz Frank; Hansruedi Glatt
Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.
Analytical chemistry 2012;84(14):6256-62.
2012: Bernhard H Monien; Albrecht Seidel; Gitte Barknowitz; Wolfram Engst; Hansruedi Glatt
Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed.
Chemical research in toxicology 2012;25(7):1484-92.
2012: Kristin Herrmann; Bernhard H Monien; Klaus E Appel; Wolfram Engst; Hansruedi Glatt
Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods.
Mutagenesis 2012;27(4):453-62.
2012: Morana Bauer-Marinovic; Simone Florian; Felicitas Taugner; Hansruedi Glatt
Toxicity studies with 5-hydroxymethylfurfural and its metabolite 5-sulphooxymethylfurfural in wild-type mice and transgenic mice expressing human sulphotransferases 1A1 and 1A2.
Archives of toxicology 2012;86(5):701-11.
2012: Simone Florian; Morana Bauer-Marinovic; Gisela Dobbernack; Walter Meinl; Bernhard H Monien; Felicitas Taugner; Hansruedi Glatt
Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2.
Molecular nutrition & food research 2012;56(4):593-600.
2011: Gisela Dobbernack; Simone Florian; Madeleine Gross; Heinz Himmelbauer; Thomas Liehr; Walter Meinl; Nicole Schade; Ingo Voigt; Korinna Wend; Hansruedi Glatt
Altered tissue distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts in mice transgenic for human sulfotransferases 1A1 and 1A2.
Carcinogenesis 2011;32(11):1734-40.
2011: Bernhard H Monien; Kristin Herrmann; Simone Florian; Hansruedi Glatt
Metabolic activation of furfuryl alcohol: formation of 2-methylfuranyl DNA adducts in Salmonella typhimurium strains expressing human sulfotransferase 1A1 and in FVB/N mice.
Carcinogenesis 2011;32(10):1533-9.
2011: Hansruedi Glatt; Chimgee Baasanjav-Gerber; Fabian Schumacher; Bernhard H Monien; Monika Schreiner; Heinz Frank; Albrecht Seidel; Wolfram Engst
1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation.
Chemico-biological interactions 2011;192(1-2):81-6.
2011: Chimgee Baasanjav-Gerber; Bernhard H Monien; Inga Mewis; Monika Schreiner; Jessica Barillari; Renato Iori; Hansruedi Glatt
Identification of glucosinolate congeners able to form DNA adducts and to induce mutations upon activation by myrosinase.
Molecular nutrition & food research 2011;55(5):783-92.
2011: Chimgee Baasanjav-Gerber; Heli Miriam Hollnagel; Jana Brauchmann; Renato Iori; Hansruedi Glatt
Detection of genotoxicants in Brassicales using endogenous DNA as a surrogate target and adducts determined by 32P-postlabelling as an experimental end point.
Mutagenesis 2011;26(3):407-13.
2010: Karl L Platt; R Edenharder; S Aderhold; Eva Muckel; Hansruedi Glatt
Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells.
Mutation research 2010;703(2):90-8.
2010: Michael Haack; Maria Löwinger; Doris Lippmann; Anna Kipp; Eleonora Pagnotta; Renato Iori; Bernhard H Monien; Hansruedi Glatt; Martin N Brauer; Ludger A Wessjohann; Regina Brigelius-Flohé
Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products.
Biological chemistry 2010;391(11):1281-93.
2010: Yungang Liu; Hansruedi Glatt
Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis.
Environmental and molecular mutagenesis 2010;51(1):23-30.
2009: Ronny Kollock; Katharina Rost; Monika Batke; Hansruedi Glatt
Effect of pentachlorophenol and 2,6-dichloro-4-nitrophenol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenases.
Toxicology letters 2009;191(2-3):360-4.
2009: Nadiya Bakhiya; Volker M Arlt; Andrew Bahn; Gerhard Burckhardt; David H Phillips; Hansruedi Glatt
Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.
Toxicology 2009;264(1-2):74-9.
2009: Nadiya Bakhiya; Bernhard Monien; Heinz Frank; Albrecht Seidel; Hansruedi Glatt
Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural.
Biochemical pharmacology 2009;78(4):414-9.
2009: Bernhard H Monien; Carolin Müller; Nadiya Bakhiya; Claudia Donath; Heinz Frank; Albrecht Seidel; Hansruedi Glatt
Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats.
Toxicology 2009;262(1):80-5.
2009: Bernhard H Monien; Heinz Frank; Albrecht Seidel; Hansruedi Glatt
Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo.
Chemical research in toxicology 2009;22(6):1123-8.
2009: Walter Meinl; Silke Sczesny; Regina Brigelius-Flohé; Michael Blaut; Hansruedi Glatt
Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(6):1179-86.
2008: Bernhard H Monien; Carolin Müller; Wolfram Engst; Heinz Frank; Albrecht Seidel; Hansruedi Glatt
Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling.
Chemical research in toxicology 2008;21(10):2017-25.
2008: Hansruedi Glatt; Katharina Rost; Heinz Frank; Albrecht Seidel; Ronny Kollock
Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1.
Archives of biochemistry and biophysics 2008;477(2):196-205.
2008: Yungang Liu; Hansruedi Glatt
Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes.
Mutation research 2008;643(1-2):64-9.
2008: Walter Meinl; Claudia Donath; Heiko Schneider; Yasmin Sommer; Hansruedi Glatt
SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(4):1249-56.
2008: Ronny Kollock; Heinz Frank; Albrecht Seidel; Walter Meinl; Hansruedi Glatt
Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases.
Toxicology 2008;245(1-2):65-75.
2008: Christine Hoelzl; Hansruedi Glatt; Walter Meinl; Gerhard Sontag; Gerald Haidinger; Michael Kundi; Tatjana Simic; Asima Chakraborty; Julia Bichler; Franziska Ferk; Karel Angelis; Armen Nersesyan; Siegfried Knasmüller
Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: results of a controlled human intervention trial.
Molecular nutrition & food research 2008;52(3):330-41.
2008: Walter Meinl; Bettina Ebert; Hansruedi Glatt; Alfonso Lampen
Sulfotransferase forms expressed in human intestinal Caco-2 and TC7 cells at varying stages of differentiation and role in benzo[a]pyrene metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):276-83.
2008: Ronny Kollock; Walter Meinl; Heiko Schneider; Monika Batke; Heinz Frank; Albrecht Seidel; Hansruedi Glatt
Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents.
Biochemical pharmacology 2008;75(2):527-37.
2007: Nadiya Bakhiya; Monika Batke; Janet Laake; Bernhard H Monien; Heinz Frank; Albrecht Seidel; Wolfram Engst; Hansruedi Glatt
Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1824-31.
2007: Volker M Arlt; Hansruedi Glatt; Gonçalo Gamboa da Costa; Jóhannes Reynisson; Takeji Takamura-Enya; David H Phillips
Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(2):445-57.
2007: Joachim Geyer; Barbara Döring; Kerstin Meerkamp; Bernhard Ugele; Nadiya Bakhiya; Carla F Fernandes; José R Godoy; Hansruedi Glatt; Ernst Petzinger
Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6).
The Journal of biological chemistry 2007;282(27):19728-41.
2007: Wera Teubner; Walter Meinl; Simone Florian; Michael Kretzschmar; Hansruedi Glatt
Identification and localization of soluble sulfotransferases in the human gastrointestinal tract.
The Biochemical journal 2007;404(2):207-15.
2006: Michael Blaut; Annett Braune; Sandra Wunderlich; Patrick Sauer; Heiko Schneider; Hansruedi Glatt
Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(11):1940-7.
2006: Morana Bauer-Marinovic; Simone Florian; Katrin Müller-Schmehl; Hansruedi Glatt; Gisela Jacobasch
Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon.
Carcinogenesis 2006;27(9):1849-59.
2006: Salah Z Al-Buheissi; Hiten R Patel; Walter Meinl; Alan Hewer; Richard L Bryan; Hansruedi Glatt; Ronald A Miller; David H Phillips
N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation.
Pharmacogenetics and genomics 2006;16(6):391-9.
2006: Nadiya Bakhiya; Monika Stephani; Andrew Bahn; Bernhard Ugele; Albrecht Seidel; Gerhard Burckhardt; Hansruedi Glatt
Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters.
Journal of the American Society of Nephrology : JASN 2006;17(5):1414-21.
2006: Gabriele Sabbioni; Christopher R Jones; Ovnair Sepai; Ari Hirvonen; Hannu Norppa; Hilkka Järventaus; Hansruedi Glatt; Doreen Pomplun; Huifang Yan; Lance R Brooks; Sarah H Warren; David M DeMarini; Yu-Ying Liu
Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(3):559-66.
2006: Tina Heine; Hansruedi Glatt; Bernd Epe
Human cytochrome P450 reductase can act as a source of endogenous oxidative DNA damage and genetic instability.
Free radical biology & medicine 2006;40(5):801-7.
2006: Walter Meinl; Ulrike Pabel; Mandy Osterloh-Quiroz; Jan G Hengstler; Hansruedi Glatt
Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue.
International journal of cancer. Journal international du cancer 2006;118(5):1090-7.
2005: Bernhard J Majer; E Hofer; Christophe Cavin; Evelyne Lhoste; Maria Uhl; Hansruedi Glatt; Walter Meinl; Siegfried Knasmüller
Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(3):433-41.
2005: Victor Moreno; Hansruedi Glatt; Elisabet Guino; Eva Fisher; Walter Meinl; Matilde Navarro; Josep M Badosa; Heiner Boeing
Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancer.
International journal of cancer. Journal international du cancer 2005;113(4):683-6.
2005: Hansruedi Glatt; Heiko Schneider; Yungang Liu
V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals.
Mutation research 2005;580(1-2):41-52.
2005: Hansruedi Glatt; Walter Meinl
Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects.
Methods in enzymology 2005;400():230-49.
2004: Susanne Schwonbeck; Andrea Krause-Griep; Nenad Gajovic-Eichelmann; Eva Ehrentreich-Förster; Walter Meinl; Hansruedi Glatt; Emmanuelle Astoul
Cohort analysis of a single nucleotide polymorphism on DNA chips.
Biosensors & bioelectronics 2004;20(5):956-66.
2004: Heiko Schneider; Hansruedi Glatt
Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro.
The Biochemical journal 2004;383(Pt. 3):543-9.
2004: Hansruedi Glatt; Walter Meinl
Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of sulfotransferases and acetyltransferases in nitrofen mutagenicity.
Carcinogenesis 2004;25(5):779-86.
2004: Hansruedi Glatt; Ulrike Pabel; Walter Meinl; Hanne Frederiksen; Henrik Frandsen; Eva Muckel
Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAalphaC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes.
Carcinogenesis 2004;25(5):801-7.
2004: Bernhard J Majer; Fekadu Kassie; Y Sasaki; Wolfgang Pfau; Hansruedi Glatt; Walter Meinl; Firouz Darroudi; Siegfried Knasmüller
Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;802(1):167-73.
2004: Hansruedi Glatt; Walter Meinl
Pharmacogenetics of soluble sulfotransferases (SULTs).
Naunyn-Schmiedeberg's archives of pharmacology 2004;369(1):55-68.
2003: Monique H A Kester; Ellen Kaptein; Thirza J Roest; Caren H Van Dijk; Dick Tibboel; Walter Meinl; Hansruedi Glatt; Michael W H Coughtrie; Theo J Visser
Characterization of rat iodothyronine sulfotransferases.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E592-8.
2003: Volker M Arlt; Hansruedi Glatt; Eva Muckel; Ulrike Pabel; Bernd L Sorg; Albrecht Seidel; Heinz Frank; Heinz H Schmeiser; David H Phillips
Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells.
International journal of cancer. Journal international du cancer 2003;105(5):583-92.
2003: Nico Landes; Paul Pfluger; Dirk Kluth; Marc Birringer; Ralph Rühl; Gaby-Fleur Böl; Hansruedi Glatt; Regina Brigelius-Flohé
Vitamin E activates gene expression via the pregnane X receptor.
Biochemical pharmacology 2003;65(2):269-73.
2003: Ulrike Bernauer; Hansruedi Glatt; Barbara Heinrich-Hirsch; Yungang Liu; Eva Muckel; Barbel Vieth; Ursula Gundert-Remy
Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1.
Alternatives to laboratory animals : ATLA 2003;31(1):21-30.
2002: Walter Meinl; John Meerman; Hansruedi Glatt
Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium.
Pharmacogenetics 2002;12(9):677-89.
2002: R Edenharder; J W Sager; Hansruedi Glatt; Eva Muckel; Karl L Platt
Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells.
Mutation research 2002;521(1-2):57-72.
2002: Volker M Arlt; Hansruedi Glatt; Eva Muckel; Ulrike Pabel; Bernd L Sorg; Heinz H Schmeiser; David H Phillips
Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase.
Carcinogenesis 2002;23(11):1937-45.
2002: Wera Teubner; Walter Meinl; Hansruedi Glatt
Stable expression of rat sulfotransferase 1B1 in V79 cells: activation of benzylic alcohols to mutagens.
Carcinogenesis 2002;23(11):1877-84.
2002: Eva Muckel; Henrik Frandsen; Hansruedi Glatt
Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(8):1063-8.
2002: Wolfram Engst; Ulrike Pabel; Hansruedi Glatt
Conjugation of 4-nitrophenol and 4-hydroxylonazolac in V79-derived cells expressing individual forms of human sulphotransferases.
Environmental toxicology and pharmacology 2002;11(3-4):243-50.
2002: Monique H A Kester; Sema Bulduk; Hans van Toor; Dick Tibboel; Walter Meinl; Hansruedi Glatt; Charles N Falany; Michael W H Coughtrie; A Gerlienke Schuur; Abraham Brouwer; Theo J Visser
Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters.
The Journal of clinical endocrinology and metabolism 2002;87(3):1142-50.
2001: Walter Meinl; Hansruedi Glatt
Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene.
Biochemical and biophysical research communications 2001;288(4):855-62.
2001: Hansruedi Glatt; H Boeing; CE Engelke; L Ma; A Kuhlow; Ulrike Pabel; D Pomplun; Wera Teubner; Walter Meinl
Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.
Mutation research 2001;482(1-2):27-40.
2001: Wolfgang Pfau; S Knasmueller; Hansruedi Glatt; Henrik Frandsen; Jan Alexander; Michael Murkovic; Gerhard Sontag; T Galceran; R Edenharder; Kerstin Skog
Heterocyclic amines: human carcinogens in cooked food?
Nutrition, metabolism, and cardiovascular diseases : NMCD 2001;11(4 Suppl):82-6.
2001: J Andrew Williams; EM Stone; Giannoulis Fakis; N Johnson; J A Cordell; Walter Meinl; Hansruedi Glatt; Edith Sim; David H Phillips
N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast.
Pharmacogenetics 2001;11(5):373-88.
2000: W Davis; Alan Hewer; K M Rajkowski; Walter Meinl; Hansruedi Glatt; David H Phillips
Sex differences in the activation of tamoxifen to DNA binding species in rat liver in vivo and in rat hepatocytes in vitro: role of sulfotransferase induction.
Cancer research 2000;60(11):2887-91.
2000: Monique H A Kester; S Bulduk; Dick Tibboel; Walter Meinl; Hansruedi Glatt; Charles N Falany; Michael W H Coughtrie; Ake Bergman; S H Safe; George G J M Kuiper; A Gerlienke Schuur; Abraham Brouwer; Theo J Visser
Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs.
Endocrinology 2000;141(5):1897-900.
2000: Hansruedi Glatt; CE Engelke; Ulrike Pabel; Wera Teubner; A L Jones; Michael W H Coughtrie; Ulrich Andrae; Charles N Falany; Walter Meinl
Sulfotransferases: genetics and role in toxicology.
Toxicology letters 2000;112-113():341-8.
2000: CE Engelke; Walter Meinl; H Boeing; Hansruedi Glatt
Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2.
Pharmacogenetics 2000;10(2):163-9.
2000: P Kreis; Sebastian Brandner; Michael W H Coughtrie; Ulrike Pabel; Walter Meinl; Hansruedi Glatt; Ulrich Andrae
Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant.
Carcinogenesis 2000;21(2):295-9.
1999: Wolfram Engst; R Landsiedel; H Hermersdörfer; J Doehmer; Hansruedi Glatt
Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells.
Carcinogenesis 1999;20(9):1777-85.
1999: Monique H A Kester; Caren H Van Dijk; Dick Tibboel; A M Hood; N J Rose; Walter Meinl; Ulrike Pabel; Hansruedi Glatt; Charles N Falany; Michael W H Coughtrie; Theo J Visser
Sulfation of thyroid hormone by estrogen sulfotransferase.
The Journal of clinical endocrinology and metabolism 1999;84(7):2577-80.
1999: Monique H A Kester; Ellen Kaptein; Thirza J Roest; Caren H Van Dijk; Dick Tibboel; Walter Meinl; Hansruedi Glatt; Michael W H Coughtrie; Theo J Visser
Characterization of human iodothyronine sulfotransferases.
The Journal of clinical endocrinology and metabolism 1999;84(4):1357-64.
1999: Ernest V Curto; C Kwong; H Hermersdörfer; Hansruedi Glatt; C Santis; Victoria Virador; Vincent J Hearing; Thomas P Dooley
Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors.
Biochemical pharmacology 1999;57(6):663-72.
1999: Ulrich Andrae; P Kreis; Michael W H Coughtrie; Ulrike Pabel; Walter Meinl; I Bartsch; Hansruedi Glatt
Activation of propane 2-nitronate to a genotoxicant in V79-derived cell lines engineered for the expression of rat hepatic sulfotransferases.
Mutation research 1999;439(2):191-7.
1998: Albrecht Seidel; Thomas Friedberg; B Löllmann; A Schwierzok; M Funk; H Frank; R Holler; Franz Oesch; Hansruedi Glatt
Detoxification of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells.
Carcinogenesis 1998;19(11):1975-81.
1998: Hansruedi Glatt; W Davis; Walter Meinl; H Hermersdörfer; S Venitt; David H Phillips
Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture.
Carcinogenesis 1998;19(10):1709-13.
1998: R Landsiedel; Ulrike Pabel; Wolfram Engst; J Ploschke; Albrecht Seidel; Hansruedi Glatt
Chiral inversion of 1-hydroxyethylpyrene enantiomers mediated by enantioselective sulfotransferases.
Biochemical and biophysical research communications 1998;247(1):181-5.
1998: Theo J Visser; Ellen Kaptein; Hansruedi Glatt; I Bartsch; M Hagen; Michael W H Coughtrie
Characterization of thyroid hormone sulfotransferases.
Chemico-biological interactions 1998;109(1-3):279-91.
1998: M Hagen; Ulrike Pabel; R Landsiedel; I Bartsch; Charles N Falany; Hansruedi Glatt
Expression of human estrogen sulfotransferase in Salmonella typhimurium: differences between hHST and hEST in the enantioselective activation of 1-hydroxyethylpyrene to a mutagen.
Chemico-biological interactions 1998;109(1-3):249-53.
1998: Hansruedi Glatt; I Bartsch; S Christoph; Michael W H Coughtrie; Charles N Falany; M Hagen; R Landsiedel; Ulrike Pabel; David H Phillips; Albrecht Seidel; Y Yamazoe
Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems.
Chemico-biological interactions 1998;109(1-3):195-219.
1997: Andreas Luch; Albrecht Seidel; Hansruedi Glatt; Karl L Platt
Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.
Chemical research in toxicology 1997;10(10):1161-70.
1997: Hansruedi Glatt
Sulfation and sulfotransferases 4: bioactivation of mutagens via sulfation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(5):314-21.
1995: Hansruedi Glatt; I Bartsch; A Czich; Albrecht Seidel; Charles N Falany
Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases.
Toxicology letters 1995;82-83():829-34.
1995: Isabella Sbrana; A Puliti; Albrecht Seidel; Hansruedi Glatt; G Turchi
Induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells in culture by pyrene and benzo[a]pyrene quinones.
Mutagenesis 1995;10(6):505-12.
1995: Hansruedi Glatt; K Pauly; A Czich; Josie L Falany; Charles N Falany
Activation of benzylic alcohols to mutagens by rat and human sulfotransferases expressed in Escherichia coli.
European journal of pharmacology 1995;293(2):173-81.
1994: Hansruedi Glatt; K Pauly; H Frank; Albrecht Seidel; Franz Oesch; R G Harvey; G Werle-Schneider
Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat.
Carcinogenesis 1994;15(11):2605-11.
1994: Andreas Luch; Hansruedi Glatt; Karl L Platt; Franz Oesch; Albrecht Seidel
Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene.
Carcinogenesis 1994;15(11):2507-16.
1994: Franz Oesch; Barbara Oesch-Bartlomowicz; J Arens; F Fähndrich; E Vogel; Thomas Friedberg; Hansruedi Glatt
Mechanism-based predictions of interactions.
Environmental health perspectives 1994;102 Suppl 9():5-9.
1994: Hansruedi Glatt; Albrecht Seidel; Franz Oesch; A Gumbsch
Fjord-region diol-epoxides of benzo[c]chrysene are potent inducers of micronuclei in murine bone marrow.
Mutation research 1994;309(1):37-43.
1994: Hansruedi Glatt
Comparison of common gene mutation tests in mammalian cells in culture: a position paper of the GUM Commission for the Development of Guidelines for Genotoxicity Testing.
Mutation research 1994;313(1):7-20.
1994: Hansruedi Glatt; E Abu-Shqara; R G Harvey; J Blum
Mutagenicity of K-region oxides and imines of chrysene, benzo[c]phenanthrene and benzo[g]chrysene in Salmonella typhimurium.
Mutation research 1994;308(2):135-41.
1994: Hansruedi Glatt; A Staffa-Piée; N Enders; W Baidossi; J Blum
The presence of KCl in the exposure medium strongly influences the mutagenicity of metabolites of polycyclic aromatic hydrocarbons in Escherichia coli.
Mutation research 1994;324(3):111-4.
1994: Hansruedi Glatt; K Pauly; A Piée-Staffa; Albrecht Seidel; S Hornhardt; A Czich
Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continuous cell cultures.
Toxicology letters 1994;72(1-3):13-21.
1994: Hansruedi Glatt; G Werle-Schneider; N Enders; S Monnerjahn; J Pudil; A Czich; Albrecht Seidel; M Schwarz
1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects.
Chemico-biological interactions 1994;92(1-3):305-19.
1994: Hansruedi Glatt; E Abu-Shqara; U Martiné; W Baidossi; R G Harvey; J Blum
K-region oxides and imines derived from alkylated benz[a]anthracene congeners: synthesis, stability in aqueous media and mutagenicity.
Mutagenesis 1994;9(2):83-92.
1994: Thomas Friedberg; R Becker; Franz Oesch; Hansruedi Glatt
Studies on the importance of microsomal epoxide hydrolase in the detoxification of arene oxides using the heterologous expression of the enzyme in mammalian cells.
Carcinogenesis 1994;15(2):171-5.
1993: A Krämer; J Pudil; H Frank; Franz Oesch; Hansruedi Glatt
Some substrates and inhibitors of cytosolic epoxide hydrolase induce sister-chromatid exchanges in mammalian cells, but do not induce gene mutations in Salmonella typhimurium and V79 cells.
Mutation research 1993;290(2):165-74.
1993: G Werle-Schneider; M Schwarz; Hansruedi Glatt
Development of hydroxysteroid sulfotransferase-deficient lesions during hepatocarcinogenesis in rats.
Carcinogenesis 1993;14(11):2267-70.
1993: Hansruedi Glatt; R Henschler; H Frank; A Seidel; C Yang; E Abu-Shqara; R G Harvey
Sulfotransferase-mediated mutagenicity of 1-hydroxymethylpyrene and 4H-cyclopenta[def]chrysen-4-ol and its enhancement by chloride anions.
Carcinogenesis 1993;14(4):599-602.
1993: Hansruedi Glatt; C Wameling; S Elsberg; H Thomas; H Marquardt; A Hewer; D H Phillips; Franz Oesch; A Seidel
Genotoxicity characteristics of reverse diol-epoxides of chrysene.
Carcinogenesis 1993;14(1):11-9.
1992: Hansruedi Glatt; E Anklam; L W Robertson
Biphenyl and fluorinated derivatives: liver enzyme-mediated mutagenicity detected in Salmonella typhimurium and Chinese hamster V79 cells.
Mutation research 1992;281(3):151-6.
1991: A Krämer; H Frank; F Setiabudi; Franz Oesch; Hansruedi Glatt
Influence of the level of cytosolic epoxide hydrolase on the induction of sister chromatid exchanges by trans-beta-ethylstyrene 7,8-oxide in human lymphocytes.
Biochemical pharmacology 1991;42(11):2147-52.
1991: Hansruedi Glatt; U Martiné; W Baidossi; J Blum
Strong influence of the exposure medium on mutagenicity in the Ames test: 7-methylbenz[a]anthracene-5,6-oxide.
Mutagenesis 1991;6(6):537-40.
1991: Hansruedi Glatt; A Piée; K Pauly; T Steinbrecher; R Schrode; Franz Oesch; A Seidel
Fjord- and bay-region diol-epoxides investigated for stability, SOS induction in Escherichia coli, and mutagenicity in Salmonella typhimurium and mammalian cells.
Cancer research 1991;51(6):1659-67.
1991: Franz Oesch; Ingolf Gath; T Igarashi; Hansruedi Glatt; Barbara Oesch-Bartlomowicz; H Thomas
Role of the well-known basic and recently discovered acidic glutathione S-transferases in the control of genotoxic metabolites.
Advances in experimental medicine and biology 1991;283():25-39.
1991: C Wölfel; Karl L Platt; S Dogra; Hansruedi Glatt; F Wächter; Johannes Doehmer
Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster cells.
Molecular carcinogenesis 1991;4(6):489-98.
1990: Hansruedi Glatt; R Henschler; D H Phillips; J W Blake; P Steinberg; A Seidel; Franz Oesch
Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells.
Environmental health perspectives 1990;88():43-8.
1990: Hansruedi Glatt; I Gemperlein; F Setiabudi; Karl L Platt; Franz Oesch
Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds.
Mutagenesis 1990;5(3):241-9.
1990: Hansruedi Glatt; G Witz
Studies on the induction of gene mutations in bacterial and mammalian cells by the ring-opened benzene metabolites trans,trans-muconaldehyde and trans,trans-muconic acid.
Mutagenesis 1990;5(3):263-6.
1990: Hansruedi Glatt
Endogenous mutagens derived from amino acids.
Mutation research 1990;238(3):235-43.
1990: S Dogra; Johannes Doehmer; Hansruedi Glatt; H Mölders; P Siegert; Thomas Friedberg; A Seidel; Franz Oesch
Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.
Molecular pharmacology 1990;37(5):608-13.
1990: Hansruedi Glatt; D Utesch; M Herbst; Franz Oesch
Mutagenicity experiments on L-cysteine and D-penicillamine using V79 cells as indicators and for metabolic activation.
Mutation research 1990;243(3):187-93.
1990: Franz Oesch; Johannes Doehmer; Thomas Friedberg; Hansruedi Glatt; Barbara Oesch-Bartlomowicz; Karl L Platt; P Steinberg; D Utesch; H Thomas
Control of ultimate mutagenic species by diverse enzymes.
Progress in clinical and biological research 1990;340B():49-65.
1989: G Ludewig; S Dogra; Hansruedi Glatt
Genotoxicity of 1,4-benzoquinone and 1,4-naphthoquinone in relation to effects on glutathione and NAD(P)H levels in V79 cells.
Environmental health perspectives 1989;82():223-8.
1989: Hansruedi Glatt; R Padykula; G A Berchtold; G Ludewig; Karl L Platt; Jochen Klein; Franz Oesch
Multiple activation pathways of benzene leading to products with varying genotoxic characteristics.
Environmental health perspectives 1989;82():81-9.
1989: Hansruedi Glatt
Mutagenicity spectra in Salmonella typhimurium strains of glutathione, L-cysteine and active oxygen species.
Mutagenesis 1989;4(3):221-7.
1989: Hansruedi Glatt; R G Harvey; D H Phillips; A Hewer; P L Grover
Influence of the alkyl substituent on mutagenicity and covalent DNA binding of bay region diol-epoxides of 7-methyl- and 7-ethylbenz(a)anthracene in Salmonella and V79 Chinese hamster cells.
Cancer research 1989;49(7):1778-82.
1989: Johannes Doehmer; S Dogra; M Edigkaufer; E Molitor; P Siegert; Thomas Friedberg; Hansruedi Glatt; K Platt; A Seidel; H Thomas
Introduction of cytochrome P-450 genes into V79 Chinese hamster cells to generate new mutagenicity test systems.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1989;13():164-8.
1988: Johannes Doehmer; S Dogra; Thomas Friedberg; S Monier; Milton Adesnik; Hansruedi Glatt; Franz Oesch
Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5769-73.
1988: Franz Oesch; Hansruedi Glatt; D Utesch
Metabolic perspectives on in vitro toxicity tests.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18 Suppl 1():35-44.
1987: Hansruedi Glatt; A Seidel; O Ribeiro; C Kirkby; P Hirom; Franz Oesch
Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene.
Carcinogenesis 1987;8(11):1621-7.
1987: Hansruedi Glatt; I Gemperlein; G Turchi; H Heinritz; Johannes Doehmer; Franz Oesch
Search for cell culture systems with diverse xenobiotic-metabolizing activities and their use in toxicological studies.
Molecular toxicology 1987;1(4):313-34.
1987: D Utesch; Hansruedi Glatt; F Oesch
Rat hepatocyte-mediated bacterial mutagenicity in relation to the carcinogenic potency of benz(a)anthracene, benzo(a)pyrene, and twenty-five methylated derivatives.
Cancer research 1987;47(6):1509-15.
1986: Hansruedi Glatt; Franz Oesch; H G Neumann
V79 Chinese hamster cells deacetylate trans-N-acetoxy-4-acetylaminostilbene and trans-N-hydroxy-4-acetylaminostilbene to mutagenic and cytotoxic metabolites.
Cell biology and toxicology 1986;2(2):213-21.
1986: Hansruedi Glatt; S Shtelzer; T Sheradsky; J Blum; Franz Oesch
Mutagenicity of N-substituted phenanthrene 9,10-imines in Salmonella typhimurium and Chinese hamster V79 cells.
Environmental mutagenesis 1986;8(6):829-37.
1985: Hansruedi Glatt; G Ludewig; Karl L Platt; F Waechter; I Yona; S Ben-Shoshan; P Jerushalmy; J Blum; Franz Oesch
Arene imines, a new class of exceptionally potent mutagens in bacterial and mammalian cells.
Cancer research 1985;45(6):2600-7.