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Martin Gleave

Research Profile

Disorders

Prostatic Neoplasms

Living Beings

Chemicals & Drugs

Anatomy

Physiology

Procedures

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Blotting, Western

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Publications

TOP 3
N Li; A Zoubeidi; Eliana Beraldi; Martin E Gleave
GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.
Akira Watahiki; Francesco Crea; Martin E Gleave; Cheryl D Helgason; Robyn J Macfarlane; Yuzhuo Wang; Kim N Chi
Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.
Chunxiao Wu; Alexander W Wyatt; Yongjun Zhao; Steven J M Jones; Martin E Gleave; Anna V Lapuk; Dong Lin; Marco A Marra; Brian J McConeghy; Andrew McPherson; Fan Mo; S Cenk Sahinalp; Robert Shukin; Stanislav V Volik; Yuzhuo Wang; Colin C Collins
Poly-gene fusion transcripts and chromothripsis in prostate cancer.

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All Publications

2013: N Li; A Zoubeidi; Eliana Beraldi; Martin E Gleave
GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.
Oncogene 2013;32(15):1933-42.
2013: Akira Watahiki; Francesco Crea; Martin E Gleave; Cheryl D Helgason; Robyn J Macfarlane; Yuzhuo Wang; Kim N Chi
Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer.
International journal of molecular sciences 2013;14(4):7757-70.
2012: Chunxiao Wu; Alexander W Wyatt; Yongjun Zhao; Steven J M Jones; Martin E Gleave; Anna V Lapuk; Dong Lin; Marco A Marra; Brian J McConeghy; Andrew McPherson; Fan Mo; S Cenk Sahinalp; Robert Shukin; Stanislav V Volik; Yuzhuo Wang; Colin C Collins
Poly-gene fusion transcripts and chromothripsis in prostate cancer.
Genes, chromosomes & cancer 2012;51(12):1144-53.
2012: Yohann Loriot; Amina Zoubeidi; Martin E Gleave
Targeted therapies in metastatic castration-resistant prostate cancer: beyond the androgen receptor.
The Urologic clinics of North America 2012;39(4):517-31.
2012: Masaki Shiota; Ario Takeuchi; Anousheh Zardan; Amina Zoubeidi; Eliana Beraldi; Masafumi Kumano; Seiji Naito; Martin E Gleave
Clusterin mediates TGF-β-induced epithelial-mesenchymal transition and metastasis via Twist1 in prostate cancer cells.
Cancer research 2012;72(20):5261-72.
2012: Hans H Adomat; Onkar S Bains; Martin E Gleave; Thomas A Grigliatti; Emma S Guns; Joanna M Lubieniecka; Ronald E Reid; K Wayne Riggs
Validation of a sequential extraction and liquid chromatography-tandem mass spectrometric method for determination of dihydrotestosterone, androstanediol and androstanediol-glucuronide in prostate tissues.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;902():84-95.
2012: Masafumi Kumano; Masaki Shiota; Romina M Wiedmann; Anousheh Zardan; Fan Zhang; Amina Zoubeidi; Eliana Beraldi; Ladan Fazli; Junya Furukawa; Martin E Gleave
Cotargeting stress-activated Hsp27 and autophagy as a combinatorial strategy to amplify endoplasmic reticular stress in prostate cancer.
Molecular cancer therapeutics 2012;11(8):1661-71.
2012: Kim N Chi; Ladan Fazli; Martin E Gleave; S Larry Goldenberg; Christian Kollmannsberger; Nevin Murray; Alan So; Anna Tinker; Michael Pollak
A phase II pharmacodynamic study of preoperative figitumumab in patients with localized prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(12):3407-13.
2012: Latif A Wafa; Helen Cheng; Michael E Cox; Ladan Fazli; Takahiro Fukumoto; Fariba Ghaidi; Martin E Gleave; Nathan Plaa; Paul S Rennie
Carbidopa abrogates L-dopa decarboxylase coactivation of the androgen receptor and delays prostate tumor progression.
International journal of cancer. Journal international du cancer 2012;130(12):2835-44.
2012: N Hayashi; Eliana Beraldi; Martin E Gleave; James W Peacock; A Zoubeidi; Christopher J Ong
Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch.
Cell death and differentiation 2012;19(6):990-1002.
2012: Christian Thomas; Latif A Wafa; Helen Cheng; Ladan Fazli; Martin E Gleave; Francois Lamoureux; Paul S Rennie
Carbidopa enhances antitumoral activity of bicalutamide on the androgen receptor-axis in castration-resistant prostate tumors.
The Prostate 2012;72(8):875-85.
2012: Chunxiao Wu; Alexander W Wyatt; Shawn Anderson; Robert H Bell; Paul C Boutros; Sonal Brahmbhatt; Robert G Bristow; Yaron S N Butterfield; Arul M Chinnaiyan; Ladan Fazli; Martin E Gleave; Faraz Hach; Anne Haegert; IMAN HAJIRASOULIHA; Martin Hirst; Fereydoun Hormozdiari; Antonio Hurtado-coll; Edward C Jones; Steven Jm Jones; Anna V Lapuk; Estelle Li; Christopher A Maher; Marco A Marra; Brian J McConeghy; Andrew McPherson; Fan Mo; S Cenk Sahinalp; Robert Shukin; Stanislav V Volik; Colin C Collins
Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer.
The Journal of pathology 2012;227(1):53-61.
2012: Qiunong Guan; Shuyuan Li; Christopher Nguan; Gordon Yip; Martin E Gleave; Caigan Du
Decrease in donor heart injury by recombinant clusterin protein in cold preservation with University of Wisconsin solution.
Surgery 2012;151(3):364-71.
2012: Niall M Corcoran; Rowan G Casey; Stephen Connolly; Martin E Gleave; S Larry Goldenberg; Laurence Harewood; Matthew K-H Hong; Christopher M Hovens; John Pedersen; Justin Peters; Anthony J Costello
Underestimation of Gleason score at prostate biopsy reflects sampling error in lower volume tumours.
BJU international 2012;109(5):660-4.
2012: Yoshiyuki Matsui; Osamu Ogawa; Peter A Raven; Baljinder Salh; Kiran Assi; Shoukat Dedhar; Martin E Gleave; Alan I So
The importance of integrin-linked kinase in the regulation of bladder cancer invasion.
International journal of cancer. Journal international du cancer 2012;130(3):521-31.
2012: Clement Mugabe; Peter A Raven; Alan I So; Jennifer H E Baker; Donald E Brooks; Ladan Fazli; Martin E Gleave; John K Jackson; Richard T Liggins; Andrew I Minchinton; Helen M Burt
Tissue uptake of docetaxel loaded hydrophobically derivatized hyperbranched polyglycerols and their effects on the morphology of the bladder urothelium.
Biomaterials 2012;33(2):692-703.
2011: Niall M Corcoran; Anthony J Costello; Rowan G Casey; S Larry Goldenberg; Laurence Harewood; Matthew K-H Hong; Christopher M Hovens; Antonio Hurtado-coll; Justin Peters; Martin E Gleave
Upgrade in Gleason score between prostate biopsies and pathology following radical prostatectomy significantly impacts upon the risk of biochemical recurrence.
BJU international 2011;108(8 Pt 2):E202-10.
2011: Francois Lamoureux; Christian Thomas; Min-Jean Yin; Amina Zoubeidi; Eliana Beraldi; Ladan Fazli; Hidetoshi Kuruma; Martin E Gleave
Clusterin inhibition using OGX-011 synergistically enhances Hsp90 inhibitor activity by suppressing the heat shock response in castrate-resistant prostate cancer.
Cancer research 2011;71(17):5838-49.
2011: Daher C Chade; Angel M Cronin; Marcos Dall'Oglio; Michael L Blute; Alberto Briganti; Martin E Gleave; Guilherme Godoy; Antonio Hurtado-coll; Steven Joniau; R Jeffrey Karnes; Francesco Montorsi; Caroline J Savage; Peter T Scardino; Shahrokh F Shariat; Miguel Srougi; Henk G van der Poel; Hendrik Van Poppel; James A Eastham
Salvage radical prostatectomy for radiation-recurrent prostate cancer: a multi-institutional collaboration.
European urology 2011;60(2):205-10.
2011: Shuyuan Li; Christopher Nguan; Zhishui Chen; Martin E Gleave; Qiunong Guan; Caigan Du
Reduction of cold ischemia-reperfusion injury by graft-expressing clusterin in heart transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011;30(7):819-26.
2011: Clement Mugabe; Yoshiyuki Matsui; Alan I So; Martin E Gleave; Jennifer H E Baker; Andrew I Minchinton; Irina Manisali; Richard Liggins; Donald E Brooks; Helen M Burt
In vivo evaluation of mucoadhesive nanoparticulate docetaxel for intravesical treatment of non-muscle-invasive bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(9):2788-98.
2011: Francois Lamoureux; Christian Thomas; Min-Jean Yin; Hidetoshi Kuruma; Ladan Fazli; Martin E Gleave; Amina Zoubeidi
A novel HSP90 inhibitor delays castrate-resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2301-13.
2011: Clement Mugabe; Yoshiyuki Matsui; Alan I So; Martin E Gleave; Markus Heller; Magali Zeisser-Labouèbe; Lindsay Heller; Irina Chafeeva; Donald E Brooks; Helen M Burt
In vitro and in vivo evaluation of intravesical docetaxel loaded hydrophobically derivatized hyperbranched polyglycerols in an orthotopic model of bladder cancer.
Biomacromolecules 2011;12(4):949-60.
2011: Kiyoshi Takahara; Howard Tearle; Mazyar Ghaffari; Martin E Gleave; Michael Pollak; Michael E Cox
Human prostate cancer xenografts in lit/lit mice exhibit reduced growth and androgen-independent progression.
The Prostate 2011;71(5):525-37.
2010: A Koupparis; Martin E Gleave
Multimodal approaches to high-risk prostate cancer.
Current oncology (Toronto, Ont.) 2010;17 Suppl 2():S33-7.
2010: Vanessa C Thompson; Antonio Hurtado-coll; Dmitry Turbin; Ladan Fazli; Melanie L Lehman; Martin E Gleave; Colleen C Nelson
Relaxin drives Wnt signaling through upregulation of PCDHY in prostate cancer.
The Prostate 2010;70(10):1134-45.
2010: Anthony J Koupparis; Martin E Gleave
Words of wisdom. Re: comparative effectiveness of minimally invasive versus open radical prostatectomy.
European urology 2010;57(6):1118-9.
2010: Amina Zoubeidi; Anousheh Zardan; Romina M Wiedmann; Jennifer Locke; Eliana Beraldi; Ladan Fazli; Martin E Gleave
Hsp27 promotes insulin-like growth factor-I survival signaling in prostate cancer via p90Rsk-dependent phosphorylation and inactivation of BAD.
Cancer research 2010;70(6):2307-17.
2010: Wenjun Zhou; Qiunong Guan; Chris C H Kwan; Huifang Chen; Martin E Gleave; Christopher Y C Nguan; Caigan Du
Loss of clusterin expression worsens renal ischemia-reperfusion injury.
American journal of physiology. Renal physiology 2010;298(3):F568-78.
2010: Jennifer A Locke; Emma S Guns; Melanie L Lehman; Susan Ettinger; Amina Zoubeidi; Amy Lubik; Katia Margiotti; Ladan Fazli; Hans Adomat; Kishor M Wasan; Martin E Gleave; Colleen C Nelson
Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance.
The Prostate 2010;70(3):239-51.
2010: Junya Furukawa; Christopher J Wraight; Susan M Freier; Eigan Peralta; Lynne M Atley; Brett P Monia; Martin E Gleave; Michael E Cox
Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer.
The Prostate 2010;70(2):206-18.
2010: Jennifer H Law; Yvonne Li; Karen To; Michelle Wang; Arezoo Astanehe; K Lambie; Jaspreet Dhillon; Steven J M Jones; Martin E Gleave; Connie J Eaves; Sandra E Dunn
Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability.
PloS one 2010;5(9):.
2010: Amina Zoubeidi; Susan Ettinger; Eliana Beraldi; Boris A Hadaschik; Anousheh Zardan; Leo W J Klomp; Colleen C Nelson; Paul S Rennie; Martin E Gleave
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells.
Molecular cancer research : MCR 2010;8(1):119-30.
2009: Yoshiyuki Matsui; Boris A Hadaschik; Ladan Fazli; Raymond J Andersen; Martin E Gleave; Alan I So
Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer.
Molecular cancer therapeutics 2009;8(8):2402-11.
2009: Jennifer A Locke; Colleen C Nelson; Hans H Adomat; Stephen C Hendy; Martin E Gleave; Emma S Guns
Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts.
The Journal of steroid biochemistry and molecular biology 2009;115(3-5):126-36.
2009: Jennifer A Locke; Ladan Fazli; Hans Adomat; Jil Smyl; Kristin Weins; Amy A Lubik; Dale Buchanan Hales; Colleen C Nelson; Martin E Gleave; Emma S Tomlinson Guns
A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer.
The Prostate 2009;69(9):928-37.
2009: Clement Mugabe; Boris A Hadaschik; Rajesh Kumar Kainthan; Donald E Brooks; Alan I So; Martin E Gleave; Helen M Burt
Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerols for intravesical bladder cancer therapy.
BJU international 2009;103(7):978-86.
2009: James W Peacock; Jodie Palmer; Dieter Fink; Stephen Ip; Eric M Pietras; Alice L-F Mui; Stephen W Chung; Martin E Gleave; Michael E Cox; Ramon Parsons; Marcus E Peter; Christopher J Ong
PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.
Molecular and cellular biology 2009;29(5):1222-34.
2009: Mototsugu Muramaki; Alan So; Norihiro Hayashi; Richard Sowery; Hideaki Miyake; Masato Fujisawa; Martin E Gleave
Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin.
BJU international 2009;103(3):384-90.
2009: Robert Snoek; Helen Cheng; Katia Margiotti; Latif A Wafa; Charmaine A Wong; Erica Chan Wong; Ladan Fazli; Colleen C Nelson; Martin E Gleave; Paul S Rennie
In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(1):39-47.
2009: Michael E Cox; Martin E Gleave; Mahvash Zakikhani; Robert H Bell; Esther Piura; Elaine Vickers; Matthew Cunningham; Ola Larsson; Ladan Fazli; Michael Pollak
Insulin receptor expression by human prostate cancers.
The Prostate 2009;69(1):33-40.
2008: Kim N Chi; Amina Zoubeidi; Martin E Gleave
Custirsen (OGX-011): a second-generation antisense inhibitor of clusterin for the treatment of cancer.
Expert opinion on investigational drugs 2008;17(12):1955-62.
2008: B A Hadaschik; K Zhang; A I So; J C Bell; J W Thüroff; Paul S Rennie; Martin E Gleave
[Oncolytic vesicular stomatitis viruses as intravesical agents against non-muscle-invasive bladder cancer].
Der Urologe. Ausg. A 2008;47(9):1145-51.
2008: Norihiro Hayashi; Erich Koller; Ladan Fazli; Martin E Gleave
Effects of Eg5 knockdown on human prostate cancer xenograft growth and chemosensitivity.
The Prostate 2008;68(12):1283-95.
2008: Boris A Hadaschik; John Jackson; Ladan Fazli; Amina Zoubeidi; Helen M Burt; Martin E Gleave; Alan I So
Intravesically administered antisense oligonucleotides targeting heat-shock protein-27 inhibit the growth of non-muscle-invasive bladder cancer.
BJU international 2008;102(5):610-6.
2008: Jennifer A Locke; Emma S Guns; Amy A Lubik; Hans H Adomat; Stephen C Hendy; Catherine A Wood; Susan Ettinger; Martin E Gleave; Colleen C Nelson
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer.
Cancer research 2008;68(15):6407-15.
2008: Kim N Chi; Joseph L Chin; Eric Winquist; Laurence Klotz; Fred Saad; Martin E Gleave
Multicenter phase II study of combined neoadjuvant docetaxel and hormone therapy before radical prostatectomy for patients with high risk localized prostate cancer.
The Journal of urology 2008;180(2):565-70; discussion 570.
2008: Richard D Sowery; Boris A Hadaschik; Alan I So; Amina Zoubeidi; Ladan Fazli; Antonio Hurtado-coll; Martin E Gleave
Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy.
BJU international 2008;102(3):389-97.
2008: Boris A Hadaschik; Kaixin Zhang; Alan I So; Ladan Fazli; William Jia; John C Bell; Martin E Gleave; Paul S Rennie
Oncolytic vesicular stomatitis viruses are potent agents for intravesical treatment of high-risk bladder cancer.
Cancer research 2008;68(12):4506-10.
2008: Boris A Hadaschik; Melanie G ter Borg; John Jackson; Richard D Sowery; Alan I So; Helen M Burt; Martin E Gleave
Paclitaxel and cisplatin as intravesical agents against non-muscle-invasive bladder cancer.
BJU international 2008;101(11):1347-55.
2008: Boris A Hadaschik; Susan Ettinger; Richard D Sowery; Amina Zoubeidi; Raymond J Andersen; Michel Roberge; Martin E Gleave
Targeting prostate cancer with HTI-286, a synthetic analog of the marine sponge product hemiasterlin.
International journal of cancer. Journal international du cancer 2008;122(10):2368-76.
2008: Jianjun Lu; John K Jackson; Martin E Gleave; Helen M Burt
The preparation and characterization of anti-VEGFR2 conjugated, paclitaxel-loaded PLLA or PLGA microspheres for the systemic targeting of human prostate tumors.
Cancer chemotherapy and pharmacology 2008;61(6):997-1005.
2008: B Joyce Davison; Alan So; S Larry Goldenberg; Jonathan Berkowitz; Martin E Gleave
Measurement of factors influencing the participation of patients with prostate cancer in clinical trials: a Canadian perspective.
BJU international 2008;101(8):982-7.
2008: Boris A Hadaschik; Hans Adomat; Ladan Fazli; Yves Fradet; Raymond J Andersen; Martin E Gleave; Alan I So
Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(5):1510-8.
2008: Christopher M K Springate; John K Jackson; Martin E Gleave; Helen M Burt
Clusterin antisense complexed with chitosan for controlled intratumoral delivery.
International journal of pharmaceutics 2008;350(1-2):53-64.
2008: Liesel M FitzGerald; Ilir Agalliu; Karynn Johnson; Melinda A Miller; Erika M Kwon; Antonio Hurtado-coll; Ladan Fazli; Ashish B Rajput; Martin E Gleave; Michael E Cox; Elaine A Ostrander; Janet L Stanford; David Huntsman
Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.
BMC cancer 2008;8():230.
2007: Boris A Hadaschik; Peter C Black; Jason C Sea; Adam R Metwalli; Ladan Fazli; Colin P N Dinney; Martin E Gleave; Alan I So
A validated mouse model for orthotopic bladder cancer using transurethral tumour inoculation and bioluminescence imaging.
BJU international 2007;100(6):1377-84.
2007: Ashish B Rajput; Melinda A Miller; Alessandro De Luca; Niki Boyd; Sam Leung; Antonio Hurtado-coll; Ladan Fazli; Edward C Jones; Jodie B Palmer; Martin E Gleave; Michael E Cox; David Huntsman
Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers.
Journal of clinical pathology 2007;60(11):1238-43.
2007: B Joyce Davison; S Larry Goldenberg; Kristin P Wiens; Martin E Gleave
Comparing a generic and individualized information decision support intervention for men newly diagnosed with localized prostate cancer.
Cancer nursing 2007;30(5):E7-15.
2007: Boris A Hadaschik; Martin E Gleave
Therapeutic options for hormone-refractory prostate cancer in 2007.
Urologic oncology 2007;25(5):413-9.
2007: Boris A Hadaschik; Richard D Sowery; Martin E Gleave
Novel targets and approaches in advanced prostate cancer.
Current opinion in urology 2007;17(3):182-7.
2007: Boris A Hadaschik; S W Melchior; Richard D Sowery; Alan I So; Martin E Gleave
[Stress proteins in prostate cancer. Challenge and promise].
Der Urologe. Ausg. A 2007;46(5):516-20.
2007: Dawn R Cochrane; Zhou Wang; Motosugu Muramaki; Martin E Gleave; Colleen C Nelson
Differential regulation of clusterin and its isoforms by androgens in prostate cells.
The Journal of biological chemistry 2007;282(4):2278-87.
2007: Richard D Sowery; Alan I So; Martin E Gleave
Therapeutic options in advanced prostate cancer: present and future.
Current urology reports 2007;8(1):53-9.
2007: Latif A Wafa; Jodie Palmer; Ladan Fazli; Antonio Hurtado-coll; Robert H Bell; Colleen C Nelson; Martin E Gleave; Michael E Cox; Paul S Rennie
Comprehensive expression analysis of L-dopa decarboxylase and established neuroendocrine markers in neoadjuvant hormone-treated versus varying Gleason grade prostate tumors.
Human pathology 2007;38(1):161-70.
2006: Vanessa C Thompson; Tanis G W Morris; Dawn R Cochrane; John Cavanagh; Latif A Wafa; Tatyana Hamilton; Shunyou Wang; Ladan Fazli; Martin E Gleave; Colleen C Nelson
Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens.
The Prostate 2006;66(16):1698-709.
2006: Dieter Fink; Ladan Fazli; Bruce Aronow; Martin E Gleave; Christopher J Ong
Clusterin is not essential for androgen-regulated involution and regeneration of the normal mouse prostate.
The Prostate 2006;66(13):1445-54.
2006: R C Studd; Richard D Sowery; Martin E Gleave
The best local therapy for unfavorable risk prostate cancer: the role of surgery.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology 2006;58(3):99-118.
2006: Nicholas Bruchovsky; Laurence Klotz; Juanita Crook; Shawn Malone; Charles Ludgate; W James Morris; Martin E Gleave; S Larry Goldenberg
Final results of the Canadian prospective phase II trial of intermittent androgen suppression for men in biochemical recurrence after radiotherapy for locally advanced prostate cancer: clinical parameters.
Cancer 2006;107(2):389-95.
2006: Satoko Kojima; David J Mulholland; Susan Ettinger; Ladan Fazli; Colleen C Nelson; Martin E Gleave
Differential regulation of IGFBP-3 by the androgen receptor in the lineage-related androgen-dependent LNCaP and androgen-independent C4-2 prostate cancer models.
The Prostate 2006;66(9):971-86.
2006: Jerod Bertram; James W Peacock; Ladan Fazli; Alice L-F Mui; Stephen W Chung; Michael E Cox; Brett P Monia; Martin E Gleave; Christopher J Ong
Loss of PTEN is associated with progression to androgen independence.
The Prostate 2006;66(9):895-902.
2006: Kazuki Yamanaka; Palma Rocchi; Hideaki Miyake; Ladan Fazli; Alan So; Uwe Zangemeister-Wittke; Martin E Gleave
Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl-2 and Bcl-xL genes.
BJU international 2006;97(6):1300-8.
2006: Jerod Bertram; James W Peacock; Clara Tan; Alice L-F Mui; Stephen W Chung; Martin E Gleave; Shoukat Dedhar; Michael E Cox; Christopher J Ong
Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells.
Cancer research 2006;66(9):4781-8.
2005: Kazuki Yamanaka; Palma Rocchi; Hideaki Miyake; Ladan Fazli; Bob Vessella; Uwe Zangemeister-Wittke; Martin E Gleave
A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells.
Molecular cancer therapeutics 2005;4(11):1689-98.
2005: Kim N Chi; Elizabeth Eisenhauer; Ladan Fazli; Edward C Jones; S Larry Goldenberg; Jean Powers; Dongsheng Tu; Martin E Gleave
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer.
Journal of the National Cancer Institute 2005;97(17):1287-96.
2005: Emma S Guns; Xiaowei Xie; Matthew N Fedoruk; Candice Madera; Simon P Cowell; Lawrence D Mayer; Kirsten Skov; Martin E Gleave; Piotr Kozlowski
pH modulation using CsCl enhances therapeutic effects of vitamin D in LNCaP tumor bearing mice.
The Prostate 2005;64(3):316-22.
2005: Bernhard J C Eigl; Scott E Eggener; Jenny Baybik; Susan Ettinger; Kim N Chi; Colleen Nelson; Zhou Wang; Martin E Gleave
Timing is everything: preclinical evidence supporting simultaneous rather than sequential chemohormonal therapy for prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4905-11.
2005: Martin E Gleave; Brett P Monia
Antisense therapy for cancer.
Nature reviews. Cancer 2005;5(6):468-79.
2005: Kazuki Yamanaka; Martin E Gleave; Isao Hara; Mototsugu Muramaki; Hideaki Miyake
Synergistic antitumor effect of combined use of adenoviral-mediated p53 gene transfer and antisense oligodeoxynucleotide targeting clusterin gene in an androgen-independent human prostate cancer model.
Molecular cancer therapeutics 2005;4(2):187-95.
2004: Sandra L Krueckl; Robert A Sikes; N Magnus Edlund; Robert H Bell; Antonio Hurtado-coll; Ladan Fazli; Martin E Gleave; Michael E Cox
Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model.
Cancer research 2004;64(23):8620-9.
2004: Peter K Cheung; Bruce Woolcock; Hans Adomat; Margaret Sutcliffe; Terry C Bainbridge; Edward C Jones; Douglas Webber; Thomas Kinahan; Marianne D Sadar; Martin E Gleave; Juergen Vielkind
Protein profiling of microdissected prostate tissue links growth differentiation factor 15 to prostate carcinogenesis.
Cancer research 2004;64(17):5929-33.
2004: Andrew J Stephenson; Michael P Chetner; Keith Rourke; Martin E Gleave; M Signaevsky; Bruce Palmer; James Kuan; Gerald B Brock; Simon Tanguay
Guidelines for the surveillance of localized renal cell carcinoma based on the patterns of relapse after nephrectomy.
The Journal of urology 2004;172(1):58-62.
2004: Duan Yu; William W-G Jia; Martin E Gleave; Colleen C Nelson; Paul S Rennie
Prostate-tumor targeting of gene expression by lentiviral vectors containing elements of the probasin promoter.
The Prostate 2004;59(4):370-82.
2004: Pepita Giménez-Bonafé; Matthew N Fedoruk; Tanis G Whitmore; Majid Akbari; Jody L Ralph; Susan Ettinger; Martin E Gleave; Colleen C Nelson
YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity.
The Prostate 2004;59(3):337-49.
2004: Susan Ettinger; Richard Sobel; Tanis G Whitmore; Majid Akbari; Dawn R Bradley; Martin E Gleave; Colleen C Nelson
Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence.
Cancer research 2004;64(6):2212-21.
2004: Laura V July; Eliana Beraldi; Alan So; Ladan Fazli; Kenneth Evans; John C English; Martin E Gleave
Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo.
Molecular cancer therapeutics 2004;3(3):223-32.
2003: Alan So; Larry Goldenberg; Martin E Gleave
Prostate specific antigen: an updated review.
The Canadian journal of urology 2003;10(6):2040-50.
2003: Alan I So; Antonio Hurtado-coll; Martin E Gleave
Androgens and prostate cancer.
World journal of urology 2003;21(5):325-37.
2003: Tobias Zellweger; Satoshi Kiyama; Kim Chi; Hideaki Miyake; Hans Adomat; Kirsten Skov; Martin E Gleave
Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model.
BJU international 2003;92(4):463-9.
2003: Satoshi Kiyama; Kevin Morrison; Tobias Zellweger; Majid Akbari; Michael Cox; Duan Yu; Hideaki Miyake; Martin E Gleave
Castration-induced increases in insulin-like growth factor-binding protein 2 promotes proliferation of androgen-independent human prostate LNCaP tumors.
Cancer research 2003;63(13):3575-84.
2003: Vladimir Mouraviev; Martin E Gleave
A meaningful legacy: urologists as Nobel Prize laureates.
The Canadian journal of urology 2003;10(1):1737-42.
2003: Colleen C Nelson; Douglas Hoffart; Martin E Gleave; Paul S Rennie
Application of gene microarrays in the study of prostate cancer.
Methods in molecular medicine 2003;81():299-320.
2003: B Joyce Davison; S Larry Goldenberg; Martin E Gleave; Lesley F Degner
Provision of individualized information to men and their partners to facilitate treatment decision making in prostate cancer.
Oncology nursing forum 2003;30(1):107-14.
2002: Tobias Zellweger; Kim Chi; Hideaki Miyake; Hans Adomat; Satoshi Kiyama; Kirsten Skov; Martin E Gleave
Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(10):3276-84.
2002: Antonio Hurtado-coll; S Larry Goldenberg; Martin E Gleave; Laurence Klotz
Intermittent androgen suppression in prostate cancer: the Canadian experience.
Urology 2002;60(3 Suppl 1):52-6; discussion 56.
2002: Antonio Hurtado-coll; S Larry Goldenberg; Laurence Klotz; Martin E Gleave
Preoperative neoadjuvant androgen withdrawal therapy in prostate cancer: the Canadian experience.
Urology 2002;60(3 Suppl 1):45-51; discussion 51.
2002: Martin E Gleave; Tobias Zellweger; Kim Chi; Hideaki Miyake; Satoshi Kiyama; Laura V July; Simon Leung
Targeting anti-apoptotic genes upregulated by androgen withdrawal using antisense oligonucleotides to enhance androgen- and chemo-sensitivity in prostate cancer.
Investigational new drugs 2002;20(2):145-58.
2002: Laura V July; Majid Akbari; Tobias Zellweger; Edward C Jones; S Larry Goldenberg; Martin E Gleave
Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy.
The Prostate 2002;50(3):179-88.
2002: B Joyce Davison; Martin E Gleave; S Larry Goldenberg; Lesley F Degner; Douglas Hoffart; Jonathan Berkowitz
Assessing information and decision preferences of men with prostate cancer and their partners.
Cancer nursing 2002;25(1):42-9.
2001: K S Poon; O Moreira; E C Jones; S Treissman; Martin E Gleave
Inflammatory pseudotumor of the urinary bladder: a report of five cases and review of the literature.
The Canadian journal of urology 2001;8(6):1409-15.
2001: Hideaki Miyake; I Hara; S Kamidono; Martin E Gleave
Synergistic chemsensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):4245-52.
2001: Tobias Zellweger; Hideaki Miyake; S Cooper; Kim Chi; B S Conklin; Brett P Monia; Martin E Gleave
Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry.
The Journal of pharmacology and experimental therapeutics 2001;298(3):934-40.
2001: Martin E Gleave; Hideaki Miyake; Tobias Zellweger; Kim Chi; Laura V July; C Nelson; Paul S Rennie
Use of antisense oligonucleotides targeting the antiapoptotic gene, clusterin/testosterone-repressed prostate message 2, to enhance androgen sensitivity and chemosensitivity in prostate cancer.
Urology 2001;58(2 Suppl 1):39-49.
2001: Martin E Gleave; S Larry Goldenberg; J L Chin; J Warner; F Saad; Laurence H Klotz; Michael Jewett; V Kassabian; Michael P Chetner; C Dupont; S Van Rensselaer
Randomized comparative study of 3 versus 8-month neoadjuvant hormonal therapy before radical prostatectomy: biochemical and pathological effects.
The Journal of urology 2001;166(2):500-6; discussion 506-7.
2001: Tobias Zellweger; Hideaki Miyake; Laura V July; Majid Akbari; Satoshi Kiyama; Martin E Gleave
Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin.
Neoplasia (New York, N.Y.) 2001;3(4):360-7.
2001: S Leung; Hideaki Miyake; Tobias Zellweger; A Tolcher; Martin E Gleave
Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model.
International journal of cancer. Journal international du cancer 2001;91(6):846-50.
2000: Marianne D Sadar; Martin E Gleave
Ligand-independent activation of the androgen receptor by the differentiation agent butyrate in human prostate cancer cells.
Cancer research 2000;60(20):5825-31.
2000: John K Jackson; Martin E Gleave; V Yago; Eliana Beraldi; William L Hunter; Helen M Burt
The suppression of human prostate tumor growth in mice by the intratumoral injection of a slow-release polymeric paste formulation of paclitaxel.
Cancer research 2000;60(15):4146-51.
2000: Martin E Gleave; S E La Bianca; S Larry Goldenberg; Edward C Jones; Nicholas Bruchovsky; LD Sullivan
Long-term neoadjuvant hormone therapy prior to radical prostatectomy: evaluation of risk for biochemical recurrence at 5-year follow-up.
Urology 2000;56(2):289-94.
2000: S Y Leung; J Jackson; H Miyake; H Burt; Martin E Gleave
Polymeric micellar paclitaxel phosphorylates Bcl-2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors.
The Prostate 2000;44(2):156-63.
2000: Hideaki Miyake; Brett P Monia; Martin E Gleave
Inhibition of progression to androgen-independence by combined adjuvant treatment with antisense BCL-XL and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model.
International journal of cancer. Journal international du cancer 2000;86(6):855-62.
2000: Hideaki Miyake; M Pollak; Martin E Gleave
Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models.
Cancer research 2000;60(11):3058-64.
2000: Hideaki Miyake; C Nelson; Paul S Rennie; Martin E Gleave
Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3'-kinase pathway.
Endocrinology 2000;141(6):2257-65.
2000: Hideaki Miyake; K N Chi; Martin E Gleave
Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1655-63.
2000: Hideaki Miyake; Colleen Nelson; Paul S Rennie; Martin E Gleave
Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models.
Cancer research 2000;60(9):2547-54.
2000: H Miayake; A Tolcher; Martin E Gleave
Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides.
Journal of the National Cancer Institute 2000;92(1):34-41.
2000: Nicholas Bruchovsky; L H Klotz; Marianne D Sadar; J M Crook; Douglas Hoffart; L Godwin; M Warkentin; Martin E Gleave; S Larry Goldenberg
Intermittent androgen suppression for prostate cancer: Canadian Prospective Trial and related observations.
Molecular urology 2000;4(3):191-9;discussion 201.
2000: Hideaki Miyake; Colleen Nelson; Paul S Rennie; Martin E Gleave
Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer.
Cancer research 2000;60(1):170-6.
1999: Martin E Gleave; H Miayake; J Goldie; Colleen Nelson; A Tolcher
Targeting bcl-2 gene to delay androgen-independent progression and enhance chemosensitivity in prostate cancer using antisense bcl-2 oligodeoxynucleotides.
Urology 1999;54(6A Suppl):36-46.
1999: Hideaki Miyake; A Tolcher; Martin E Gleave
Antisense Bcl-2 oligodeoxynucleotides inhibit progression to androgen-independence after castration in the Shionogi tumor model.
Cancer research 1999;59(16):4030-4.
1999: Albert C W Ting; Martin E Gleave; York N Hsiang
In situ replacement of the aorta in a contaminated field with the infrarenal inferior vena cava.
Journal of vascular surgery 1999;30(2):363-6.
1999: T Nickerson; H Miyake; Martin E Gleave; Michael Pollak
Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins.
Cancer research 1999;59(14):3392-5.
1999: Martin E Gleave; Nicholas Bruchovsky; M J Moore; P Venner
Prostate cancer: 9. Treatment of advanced disease.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1999;160(2):225-32.
1998: Martin E Gleave; N Sato; Marianne D Sadar; V Yago; Nicholas Bruchovsky; L Sullivan
Butyrate analogue, isobutyramide, inhibits tumor growth and time to androgen-independent progression in the human prostate LNCaP tumor model.
Journal of cellular biochemistry 1998;69(3):271-81.
1998: Martin E Gleave; M Elhilali; Y Fradet; I Davis; P Venner; F Saad; L H Klotz; M J Moore; Virginia Paton; Alex Bajamonde
Interferon gamma-1b compared with placebo in metastatic renal-cell carcinoma. Canadian Urologic Oncology Group.
The New England journal of medicine 1998;338(18):1265-71.
1998: VD Chow; LD Sullivan; J E Wright; S Larry Goldenberg; Howard N Fenster; Martin E Gleave; MG McLoughlin
Transurethral electrovaporization of the prostate versus transurethral prostatic resection: a comparison of postoperative hemorrhage.
Urology 1998;51(2):251-3.
1998: Farhang Rabbani; S Larry Goldenberg; Martin E Gleave; R F Paterson; N Murray; LD Sullivan
Retroperitoneal lymphadenectomy for post-chemotherapy residual masses: is a modified dissection and resection of residual masses sufficient?
British journal of urology 1998;81(2):295-300.
1997: N Sato; Marianne D Sadar; Nicholas Bruchovsky; F Saatcioglu; Paul S Rennie; S Sato; P H Lange; Martin E Gleave
Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP.
The Journal of biological chemistry 1997;272(28):17485-94.
1997: S Larry Goldenberg; Martin E Gleave; Nicholas Bruchovsky; Paul S Rennie
Re: Editorial comment.
The Journal of urology 1997;157(6):2267.
1997: Martin E Gleave; N Sato; S Larry Goldenberg; Lynn Stothers; Nicholas Bruchovsky; LD Sullivan
Neoadjuvant androgen withdrawal therapy decreases local recurrence rates following tumor excision in the Shionogi tumor model.
The Journal of urology 1997;157(5):1727-30.
1997: N Sato; Martin E Gleave; Nicholas Bruchovsky; Paul S Rennie; Eliana Beraldi; LD Sullivan
A metastatic and androgen-sensitive human prostate cancer model using intraprostatic inoculation of LNCaP cells in SCID mice.
Cancer research 1997;57(8):1584-9.
1997: LD Sullivan; MG McLoughlin; Larry Goldenberg; Martin E Gleave; K W Marich
Early experience with high-intensity focused ultrasound for the treatment of benign prostatic hypertrophy.
British journal of urology 1997;79(2):172-6.

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