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Laurie Glimcher

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
31
Grusby, Michael
18
Lee, Ann-Hwee
14
Iwakoshi, Neal
12
Ho, I-Cheng
12
Gravallese, Ellen
11
Szabo, Susanne
9
Ranger, AM
9
Boothby, Mark
8
Finn, Patricia
7
Sullivan, Brandon
6
Rengarajan, Jyothi
6
Oukka, Mohamed
6
Wein, Marc
6
Peng, Stanford
6
Hoey, Timothy

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Publications

TOP 3
Jenner Richard G; Townsend Michael J; Jackson Ian; Sun Kaiming; Bouwman Russell D; Young Richard A; Glimcher Laurie H; Lord Graham M
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.
Hetz Claudio; Thielen Peter; Matus Soledad; Nassif Melissa; Court Felipe; Kiffin Roberta; Martinez Gabriela; Cuervo Ana María; Brown Robert H; Glimcher Laurie H
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.
Garrett Wendy S; Glimcher Laurie H
T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships.

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All Publications

2009: Jenner Richard G; Townsend Michael J; Jackson Ian; Sun Kaiming; Bouwman Russell D; Young Richard A; Glimcher Laurie H; Lord Graham M
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17876-81.
2009: Hetz Claudio; Thielen Peter; Matus Soledad; Nassif Melissa; Court Felipe; Kiffin Roberta; Martinez Gabriela; Cuervo Ana María; Brown Robert H; Glimcher Laurie H
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.
Genes & development 2009;23(19):2294-306.
2009: Garrett Wendy S; Glimcher Laurie H
T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships.
Cytokine 2009;48(1-2):144-7.
2009: Todd Derrick J; McHeyzer-Williams Louise J; Kowal Czeslawa; Lee Ann-Hwee; Volpe Bruce T; Diamond Betty; McHeyzer-Williams Michael G; Glimcher Laurie H
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development.
The Journal of experimental medicine 2009;206(10):2151-9.
2009: Glimcher Laurie H; Lee Ann-Hwee
From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis.
Annals of the New York Academy of Sciences 2009;1173 Suppl 1():E2-9.
2009: Hetz Claudio; Glimcher Laurie H
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome.
Molecular cell 2009;35(5):551-61.
2009: Garrett Wendy S; Punit Shivesh; Gallini Carey A; Michaud Monia; Zhang Dorothy; Sigrist Kirsten S; Lord Graham M; Glickman Jonathan N; Glimcher Laurie H
Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells.
Cancer cell 2009;16(3):208-19.
2009: Lee Ann-Hwee; Glimcher Laurie H
Intersection of the unfolded protein response and hepatic lipid metabolism.
Cellular and molecular life sciences : CMLS 2009;66(17):2835-50.
2009: Shim Jae-Hyuck; Greenblatt Matthew B; Xie Min; Schneider Michael D; Zou Weiguo; Zhai Bo; Gygi Steven; Glimcher Laurie H
TAK1 is an essential regulator of BMP signalling in cartilage.
The EMBO journal 2009;28(14):2028-41.
2009: Esensten Jonathan H; Lee Michael R; Glimcher Laurie H; Bluestone Jeffrey A
T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):75-82.
2009: Yuan Xueli; Ansari M Javeed; D'Addio Francesca; Paez-Cortez Jesus; Schmitt Isabella; Donnarumma Michela; Boenisch Olaf; Zhao Xiaozhi; Popoola Joyce; Clarkson Michael R; Yagita Hideo; Akiba Hisaya; Freeman Gordon J; Iacomini John; Turka Laurence A; Glimcher Laurie H; Sayegh Mohamed H
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(26):10734-9.
2009: Glimcher Laurie H; Lieberman Judy
Harvard's women four years later.
Nature immunology 2009;10(6):559-61.
2009: Maldonado Roberto A; Soriano Michelle A; Perdomo L Carolina; Sigrist Kirsten; Irvine Darrell J; Decker Thomas; Glimcher Laurie H
Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse.
The Journal of experimental medicine 2009;206(4):877-92.
2009: Lisbona Fernanda; Rojas-Rivera Diego; Thielen Peter; Zamorano Sebastian; Todd Derrick; Martinon Fabio; Glavic Alvaro; Kress Christina; Lin Jonathan H; Walter Peter; Reed John C; Glimcher Laurie H; Hetz Claudio
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha.
Molecular cell 2009;33(6):679-91.
2009: Lazarevic Vanja; Zullo Alfred J; Schweitzer Michelle N; Staton Tracy L; Gallo Elena M; Crabtree Gerald R; Glimcher Laurie H
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.
Nature immunology 2009;10(3):306-13.
2009: Park Jung Won; Min Hyun Jung; Sohn Jung Ho; Kim Joo Young; Hong Jeong Ho; Sigrist Kirsten S; Glimcher Laurie H; Hwang Eun Sook
Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma.
The Journal of allergy and clinical immunology 2009;123(2):479-85.
2008: Wu Jing; Glimcher Laurie H; Aliprantis Antonios O
HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):16934-9.
2008: Aliprantis Antonios O; Ueki Yasuyoshi; Sulyanto Rosalyn; Park Arnold; Sigrist Kirsten S; Sharma Sudarshana M; Ostrowski Michael C; Olsen Bjorn R; Glimcher Laurie H
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism.
The Journal of clinical investigation 2008;118(11):3775-89.
2008: Kaser Arthur; Lee Ann-Hwee; Franke Andre; Glickman Jonathan N; Zeissig Sebastian; Tilg Herbert; Nieuwenhuis Edward E S; Higgins Darren E; Schreiber Stefan; Glimcher Laurie H; Blumberg Richard S
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.
Cell 2008;134(5):743-56.
2008: Todd Derrich J; Lee Ann-Hwee; Glimcher Laurie H
The endoplasmic reticulum stress response in immunity and autoimmunity.
Nature reviews. Immunology 2008;8(9):663-74.
2008: Lee Ann-Hwee; Scapa Erez F; Cohen David E; Glimcher Laurie H
Regulation of hepatic lipogenesis by the transcription factor XBP1.
Science (New York, N.Y.) 2008;320(5882):1492-6.
2008: Werneck Miriam B F; Lugo-Villarino Geanncarlo; Hwang Eun Sook; Cantor Harvey; Glimcher Laurie H
T-bet plays a key role in NK-mediated control of melanoma metastatic disease.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):8004-10.
2008: Tzianabos Arthur O; Holsti Matthew A; Zheng Xin-Xiao; Stucchi Arthur F; Kuchroo Vijay K; Strom Terry B; Glimcher Laurie H; Cruikshank William W
Functional Th1 cells are required for surgical adhesion formation in a murine model.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6970-6.
2008: Karwot Roman; Maxeiner Joachim H; Schmitt Steffen; Scholtes Petra; Hausding Michael; Lehr Hans A; Glimcher Laurie H; Finotto Susetta
Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy model.
The Journal of allergy and clinical immunology 2008;121(4):992-9.e6.
2008: Mukherjee Siddhartha; Raje Noopur; Schoonmaker Jesse A; Liu Julie C; Hideshima Teru; Wein Marc N; Jones Dallas C; Vallet Sonia; Bouxsein Mary L; Pozzi Samantha; Chhetri Shweta; Seo Y David; Aronson Joshua P; Patel Chirayu; Fulciniti Mariateresa; Purton Louise E; Glimcher Laurie H; Lian Jane B; Stein Gary; Anderson Kenneth C; Scadden David T
Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice.
The Journal of clinical investigation 2008;118(2):491-504.
2008: Horsley Valerie; Aliprantis Antonios O; Polak Lisa; Glimcher Laurie H; Fuchs Elaine
NFATc1 balances quiescence and proliferation of skin stem cells.
Cell 2008;132(2):299-310.
2008: Hetz Claudio; Lee Ann-Hwee; Gonzalez-Romero Dennisse; Thielen Peter; Castilla Joaquín; Soto Claudio; Glimcher Laurie H
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):757-62.
2008: Rengarajan Jyothi; Murphy Elissa; Park Arnold; Krone Cassandra L; Hett Erik C; Bloom Barry R; Glimcher Laurie H; Rubin Eric J
Mycobacterium tuberculosis Rv2224c modulates innate immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):264-9.
2008: Wein Marc N; Jones Dallas C; Glimcher Laurie H
Lentivirus delivery of shRNA constructs into osteoblasts.
Methods in molecular biology (Clifton, N.J.) 2008;455():149-55.
2007: Glimcher Laurie H; Jones Dallas C; Wein Marc N
Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3.
Annals of the New York Academy of Sciences 2007;1116():174-81.
2007: Jones Dallas C; Wein Marc N; Glimcher Laurie H
Schnurri-3 is an essential regulator of osteoblast function and adult bone mass.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii49-51.
2007: Garrett Wendy S; Lord Graham M; Punit Shivesh; Lugo-Villarino Geanncarlo; Mazmanian Sarkis K; Ito Susumu; Glickman Jonathan N; Glimcher Laurie H
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system.
Cell 2007;131(1):33-45.
2007: Iwakoshi Neal N; Pypaert Marc; Glimcher Laurie H
The transcription factor XBP-1 is essential for the development and survival of dendritic cells.
The Journal of experimental medicine 2007;204(10):2267-75.
2007: Erlebacher Adrian; Vencato Daniela; Price Kelly A; Zhang Dorothy; Glimcher Laurie H
Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.
The Journal of clinical investigation 2007;117(5):1399-411.
2007: Glimcher Laurie H
Trawling for treasure: tales of T-bet.
Nature immunology 2007;8(5):448-50.
2007: Aliprantis Antonios O; Wang Jingsong; Fathman John W; Lemaire Raphael; Dorfman David M; Lafyatis Robert; Glimcher Laurie H
Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2827-30.
2007: Alcaide Pilar; Jones Tatiana G; Lord Graham M; Glimcher Laurie H; Hallgren Jenny; Arinobu Yojiro; Akashi Koichi; Paterson Alison M; Gurish Michael A; Luscinskas Francis W
Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.
The Journal of experimental medicine 2007;204(2):431-9.
2007: Jones Dallas C; Wein Marc N; Glimcher Laurie H
Schnurri-3: a key regulator of postnatal skeletal remodeling.
Advances in experimental medicine and biology 2007;602():1-13.
2006: Taqueti Viviany R; Grabie Nir; Colvin Richard; Pang Hong; Jarolim Petr; Luster Andrew D; Glimcher Laurie H; Lichtman Andrew H
T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5890-901.
2006: Martinon Fabio; Glimcher Laurie H
Gout: new insights into an old disease.
The Journal of clinical investigation 2006;116(8):2073-5.
2006: Rosas Lucia E; Snider Heidi M; Barbi Joseph; Satoskar Anjali A; Lugo-Villarino Geanncarlo; Keiser Tracy; Papenfuss Tracy; Durbin Joan E; Radzioch Danuta; Glimcher Laurie H; Satoskar Abhay R
Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):22-5.
2006: Jones Dallas C; Wein Marc N; Oukka Mohamed; Hofstaetter Jochen G; Glimcher Melvin J; Glimcher Laurie H
Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.
Science (New York, N.Y.) 2006;312(5777):1223-7.
2006: Shinohara Mari L; Lu Linrong; Bu Jing; Werneck Miriam B F; Kobayashi Koichi S; Glimcher Laurie H; Cantor Harvey
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.
Nature immunology 2006;7(5):498-506.
2006: Hetz Claudio; Bernasconi Paula; Fisher Jill; Lee Ann-Hwee; Bassik Michael C; Antonsson Bruno; Brandt Gabriel S; Iwakoshi Neal N; Schinzel Anna; Glimcher Laurie H; Korsmeyer Stanley J
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.
Science (New York, N.Y.) 2006;312(5773):572-6.
2006: Tirosh Boaz; Iwakoshi Neal N; Glimcher Laurie H; Ploegh Hidde L
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response.
The Journal of biological chemistry 2006;281(9):5852-60.
2006: Wang Jingsong; Fathman John W; Lugo-Villarino Geanncarlo; Scimone Lucila; von Andrian Ulrich; Dorfman David M; Glimcher Laurie H
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells.
The Journal of clinical investigation 2006;116(2):414-21.
2006: Raby Benjamin A; Hwang Eun-Sook; Van Steen Kristel; Tantisira Kelan; Peng Stanford; Litonjua Augusto; Lazarus Ross; Giallourakis Cosmas; Rioux John D; Sparrow David; Silverman Edwin K; Glimcher Laurie H; Weiss Scott T
T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.
American journal of respiratory and critical care medicine 2006;173(1):64-70.
2005: Lee Ann-Hwee; Chu Gerald C; Iwakoshi Neal N; Glimcher Laurie H
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands.
The EMBO journal 2005;24(24):4368-80.
2005: Wein Marc N; Jones Dallas C; Glimcher Laurie H
Turning down the system: counter-regulatory mechanisms in bone and adaptive immunity.
Immunological reviews 2005;208():66-79.
2005: Shinohara Mari L; Jansson Marianne; Hwang Eun Sook; Werneck Miriam B F; Glimcher Laurie H; Cantor Harvey
T-bet-dependent expression of osteopontin contributes to T cell polarization.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17101-6.
2005: Hwang Eun Sook; Hong Jeong-Ho; Glimcher Laurie H
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508.
The Journal of experimental medicine 2005;202(9):1289-300.
2005: Lord Graham M; Rao Ravi M; Choe Hyeryun; Sullivan Brandon M; Lichtman Andrew H; Luscinskas F William; Glimcher Laurie H
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.
Blood 2005;106(10):3432-9.
2005: Ravindran Rajesh; Foley Joseph; Stoklasek Thomas; Glimcher Laurie H; McSorley Stephen J
Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4603-10.
2005: Sullivan Brandon M; Jobe Ousman; Lazarevic Vanja; Vasquez Kristine; Bronson Roderick; Glimcher Laurie H; Kramnik Igor
Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4593-602.
2005: Lugo-Villarino Geanncarlo; Ito Shu-Ichi; Klinman Dennis M; Glimcher Laurie H
The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13248-53.
2005: Tirosh Boaz; Iwakoshi Neal N; Glimcher Laurie H; Ploegh Hidde L
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells.
The Journal of experimental medicine 2005;202(4):505-16.
2005: Finotto Susetta; Hausding Michael; Doganci Aysefa; Maxeiner Joachim H; Lehr Hans A; Luft Cornelia; Galle Peter R; Glimcher Laurie H
Asthmatic changes in mice lacking T-bet are mediated by IL-13.
International immunology 2005;17(8):993-1007.
2005: Tirosh Boaz; Iwakoshi Neal N; Lilley Brendan N; Lee Ann-Hwee; Glimcher Laurie H; Ploegh Hidde L
Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products.
Journal of virology 2005;79(5):2768-79.
2005: Buono Chiara; Binder Christoph J; Stavrakis George; Witztum Joseph L; Glimcher Laurie H; Lichtman Andrew H
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1596-601.
2005: Dorfman David M; Hwang Eun Sook; Shahsafaei Aliakbar; Glimcher Laurie H
T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma.
Human pathology 2005;36(1):10-5.
2005: Hwang Eun Sook; Szabo Susanne J; Schwartzberg Pamela L; Glimcher Laurie H
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
Science (New York, N.Y.) 2005;307(5708):430-3.
2004: Tantisira Kelan G; Hwang Eun Sook; Raby Benjamin A; Silverman Eric S; Lake Stephen L; Richter Brent G; Peng Stanford L; Drazen Jeffrey M; Glimcher Laurie H; Weiss Scott T
TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):18099-104.
2004: Mowen Kerri A; Glimcher Laurie H
Signaling pathways in Th2 development.
Immunological reviews 2004;202():203-22.
2004: Glimcher Laurie H; Townsend Michael J; Sullivan Brandon M; Lord Graham M
Recent developments in the transcriptional regulation of cytolytic effector cells.
Nature reviews. Immunology 2004;4(11):900-11.
2004: Erlebacher Adrian; Price Kelly A; Glimcher Laurie H
Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin.
Developmental biology 2004;275(1):158-69.
2004: Ozcan Umut; Cao Qiong; Yilmaz Erkan; Lee Ann-Hwee; Iwakoshi Neal N; Ozdelen Esra; Tuncman Gürol; Görgün Cem; Glimcher Laurie H; Hotamisligil Gökhan S
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
Science (New York, N.Y.) 2004;306(5695):457-61.
2004: Maldonado Roberto A; Irvine Darrell J; Schreiber Robert; Glimcher Laurie H
A role for the immunological synapse in lineage commitment of CD4 lymphocytes.
Nature 2004;431(7008):527-32.
2004: Romero-Ramirez Lorenzo; Cao Hongbin; Nelson Daniel; Hammond Ester; Lee Ann-Hwee; Yoshida Hiderou; Mori Kazutoshi; Glimcher Laurie H; Denko Nicholas C; Giaccia Amato J; Le Quynh-Thu; Koong Albert C
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
Cancer research 2004;64(17):5943-7.
2004: Glimcher Laurie H
How we can help the next generation of scientists: introducing The "Hands-On" Primary Caregiver's Support Program.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):2891-2.
2004: Mowen Kerri A; Schurter Brandon T; Fathman John W; David Michael; Glimcher Laurie H
Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes.
Molecular cell 2004;15(4):559-71.
2004: Dorfman David M; Hwang Eun Sook; Shahsafaei Aliakbar; Glimcher Laurie H
T-bet, a T-cell-associated transcription factor, is expressed in a subset of B-cell lymphoproliferative disorders.
American journal of clinical pathology 2004;122(2):292-7.
2004: Shaffer A L; Shapiro-Shelef Miriam; Iwakoshi Neal N; Lee Ann-Hwee; Qian Shu-Bing; Zhao Hong; Yu Xin; Yang Liming; Tan Bruce K; Rosenwald Andreas; Hurt Elaine M; Petroulakis Emmanuel; Sonenberg Nahum; Yewdell Jonathan W; Calame Kathryn; Glimcher Laurie H; Staudt Louis M
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
Immunity 2004;21(1):81-93.
2004: Bettelli Estelle; Sullivan Brandon; Szabo Susanne J; Sobel Raymond A; Glimcher Laurie H; Kuchroo Vijay K
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2004;200(1):79-87.
2004: Erlebacher Adrian; Zhang Dorothy; Parlow Albert F; Glimcher Laurie H
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system.
The Journal of clinical investigation 2004;114(1):39-48.
2004: Lametschwandtner Günther; Biedermann Tilo; Schwärzler Christoph; Günther Claudia; Kund Julia; Fassl Sandra; Hinteregger Sonja; Carballido-Perrig Nicole; Szabo Susanne J; Glimcher Laurie H; Carballido José M
Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities.
The Journal of allergy and clinical immunology 2004;113(5):987-94.
2004: Juedes Amy E; Rodrigo Evelyn; Togher Lisa; Glimcher Laurie H; von Herrath Matthias G
T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes.
The Journal of experimental medicine 2004;199(8):1153-62.
2004: Townsend Michael J; Weinmann Amy S; Matsuda Jennifer L; Salomon Rachelle; Farnham Peggy J; Biron Christine A; Gapin Laurent; Glimcher Laurie H
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells.
Immunity 2004;20(4):477-94.
2004: Gerth Andrea J; Lin Ling; Neurath Markus F; Glimcher Laurie H; Peng Stanford L
An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells.
Gastroenterology 2004;126(4):1115-21.
2004: Peng Stanford L; Townsend Michael J; Hecht Jonathan L; White Ian A; Glimcher Laurie H
T-bet regulates metastasis rate in a murine model of primary prostate cancer.
Cancer research 2004;64(2):452-5.
2004: Oukka Mohamed; Wein Marc N; Glimcher Laurie H
Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.
The Journal of experimental medicine 2004;199(1):15-24.
2003: Sullivan Brandon M; Juedes Amy; Szabo Susanne J; von Herrath Matthias; Glimcher Laurie H
Antigen-driven effector CD8 T cell function regulated by T-bet.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15818-23.
2003: Dorfman David M; van den Elzen Peter; Weng Andrew P; Shahsafaei Aliakbar; Glimcher Laurie H
Differential expression of T-bet, a T-box transcription factor required for Th1 T-cell development, in peripheral T-cell lymphomas.
American journal of clinical pathology 2003;120(6):866-73.
2003: Pai Sung-Yun; Truitt Morgan L; Ting Chao-Nan; Leiden Jeffrey M; Glimcher Laurie H; Ho I-Cheng
Critical roles for transcription factor GATA-3 in thymocyte development.
Immunity 2003;19(6):863-75.
2003: Melanitou Evie; Liu Edwin; Miao Dongmei; Yu Liping; Glimcher Laurie H; Eisenbarth George
Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice.
Annals of the New York Academy of Sciences 2003;1005():187-91.
2003: Lee Ann-Hwee; Iwakoshi Neal N; Glimcher Laurie H
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.
Molecular and cellular biology 2003;23(21):7448-59.
2003: Iwakoshi Neal N; Lee Ann Hwee; Glimcher Laurie H
It's a good year for Blimp-1 (and plasma cells).
Immunity 2003;19(4):466-8.
2003: MacLean Helen E; Kim James I; Glimcher Melvin J; Wang Jinxi; Kronenberg Henry M; Glimcher Laurie H
Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development.
Developmental biology 2003;262(1):51-63.
2003: Lee Ann-Hwee; Iwakoshi Neal N; Anderson Kenneth C; Glimcher Laurie H
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9946-51.
2003: Iwakoshi Neal N; Lee Ann-Hwee; Glimcher Laurie H
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response.
Immunological reviews 2003;194():29-38.
2003: Lugo-Villarino Geanncarlo; Maldonado-Lopez Roberto; Possemato Richard; Penaranda Cristina; Glimcher Laurie H
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7749-54.
2003: Iwakoshi Neal N; Lee Ann-Hwee; Vallabhajosyula Prasanth; Otipoby Kevin L; Rajewsky Klaus; Glimcher Laurie H
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.
Nature immunology 2003;4(4):321-9.
2003: Lyon Mary F; Jamieson Robyn V; Perveen Rahat; Glenister Peter H; Griffiths Robert; Boyd Yvonne; Glimcher Laurie H; Favor Jack; Munier Francis L; Black Graeme C M
A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding.
Human molecular genetics 2003;12(6):585-94.
2003: Szabo Susanne J; Sullivan Brandon M; Peng Stanford L; Glimcher Laurie H
Molecular mechanisms regulating Th1 immune responses.
Annual review of immunology 2003;21():713-58.
2002: Erlebacher Adrian; Lukens Amanda K; Glimcher Laurie H
Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16940-5.
2002: Avni Orly; Lee Dong; Macian Fernando; Szabo Susanne J; Glimcher Laurie H; Rao Anjana
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.
Nature immunology 2002;3(7):643-51.
2002: Neurath Markus F; Finotto Susetta; Glimcher Laurie H
The role of Th1/Th2 polarization in mucosal immunity.
Nature medicine 2002;8(6):567-73.
2002: Neurath M F; Weigmann B; Finotto S; Glickman J; Nieuwenhuis E; Iijima H; Mizoguchi A; Mizoguchi E; Mudter J; Galle P R; Bhan A; Autschbach F; Sullivan B M; Szabo S J; Glimcher L H; Blumberg R S
The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease.
The Journal of experimental medicine 2002;195(9):1129-43.
2002: Ho I-Cheng; Glimcher Laurie H
Transcription: tantalizing times for T cells.
Cell 2002;109 Suppl():S109-20.
2002: Peng Stanford L; Szabo Susanne J; Glimcher Laurie H
T-bet regulates IgG class switching and pathogenic autoantibody production.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5545-50.
2002: Rengarajan Jyothi; Mowen Kerri A; McBride Kathryn D; Smith Erica D; Singh Harinder; Glimcher Laurie H
Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.
The Journal of experimental medicine 2002;195(8):1003-12.
2002: Yin Zhinan; Chen ChangHung; Szabo Susanne J; Glimcher Laurie H; Ray Anuradha; Craft Joe
T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1566-71.
2002: Oukka Mohamed; Kim Sean T; Lugo Geancarlo; Sun Jenny; Wu Lai-Chu; Glimcher Laurie H
A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.
Molecular cell 2002;9(1):121-31.
2002: Szabo Susanne J; Sullivan Brandon M; Stemmann Claudia; Satoskar Abhay R; Sleckman Barry P; Glimcher Laurie H
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
Science (New York, N.Y.) 2002;295(5553):338-42.
2002: Finotto Susetta; Neurath Markus F; Glickman Jonathan N; Qin Shixin; Lehr Hans A; Green Francis H Y; Ackerman Kate; Haley Kathleen; Galle Peter R; Szabo Susanne J; Drazen Jeffrey M; De Sanctis George T; Glimcher Laurie H
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.
Science (New York, N.Y.) 2002;295(5553):336-8.
2002: Rengarajan Jyothi; Tang Betty; Glimcher Laurie H
NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells.
Nature immunology 2002;3(1):48-54.
2001: Glimcher L H
Lineage commitment in lymphocytes: controlling the immune response.
The Journal of clinical investigation 2001;108(7):s25-s30.
2001: Reimold A M; Iwakoshi N N; Manis J; Vallabhajosyula P; Szomolanyi-Tsuda E; Gravallese E M; Friend D; Grusby M J; Alt F; Glimcher L H
Plasma cell differentiation requires the transcription factor XBP-1.
Nature 2001;412(6844):300-7.
2001: Lieberson R; Mowen K A; McBride K D; Leautaud V; Zhang X; Suh W K; Wu L; Glimcher L H
Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45).
The Journal of experimental medicine 2001;194(1):89-98.
2001: Ho I C; Arm J P; Bingham C O; Choi A; Austen K F; Glimcher L H
A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells.
The Journal of biological chemistry 2001;276(21):18321-6.
2001: Peng S L; Gerth A J; Ranger A M; Glimcher L H
NFATc1 and NFATc2 together control both T and B cell activation and differentiation.
Immunity 2001;14(1):13-20.
2000: Rengarajan J; Szabo S J; Glimcher L H
Transcriptional regulation of Th1/Th2 polarization.
Immunology today 2000;21(10):479-83.
2000: Tsai E Y; Falvo J V; Tsytsykova A V; Barczak A K; Reimold A M; Glimcher L H; Fenton M J; Gordon D C; Dunn I F; Goldfeld A E
A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo.
Molecular and cellular biology 2000;20(16):6084-94.
2000: Glimcher L H; Murphy K M
Lineage commitment in the immune system: the T helper lymphocyte grows up.
Genes & development 2000;14(14):1693-711.
2000: Szabo S J; Kim S T; Costa G L; Zhang X; Fathman C G; Glimcher L H
A novel transcription factor, T-bet, directs Th1 lineage commitment.
Cell 2000;100(6):655-69.
2000: Rengarajan J; Mittelstadt P R; Mages H W; Gerth A J; Kroczek R A; Ashwell J D; Glimcher L H
Sequential involvement of NFAT and Egr transcription factors in FasL regulation.
Immunity 2000;12(3):293-300.
2000: Reimold A M; Etkin A; Clauss I; Perkins A; Friend D S; Zhang J; Horton H F; Scott A; Orkin S H; Byrne M C; Grusby M J; Glimcher L H
An essential role in liver development for transcription factor XBP-1.
Genes & development 2000;14(2):152-7.
2000: Ranger A M; Gerstenfeld L C; Wang J; Kon T; Bae H; Gravallese E M; Glimcher M J; Glimcher L H
The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis.
The Journal of experimental medicine 2000;191(1):9-22.
1999: de Bont E S; Reilly C R; Lo D; Glimcher L H; Laufer T M
A minimal level of MHC class II expression is sufficient to abrogate autoreactivity.
International immunology 1999;11(8):1295-306.
1999: Kim J I; Ho I C; Grusby M J; Glimcher L H
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines.
Immunity 1999;10(6):745-51.
1999: Laufer T M; Fan L; Glimcher L H
Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5078-84.
1999: Kim J I; Li T; Ho I C; Grusby M J; Glimcher L H
Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3781-5.
1999: Ho I C; Kaplan M H; Jackson-Grusby L; Glimcher L H; Grusby M J
Marking IL-4-producing cells by knock-in of the IL-4 gene.
International immunology 1999;11(2):243-7.
1999: Laufer T M; Glimcher L H; Lo D
Using thymus anatomy to dissect T cell repertoire selection.
Seminars in immunology 1999;11(1):65-70.
1999: Glimcher L H; Singh H
Transcription factors in lymphocyte development--T and B cells get together.
Cell 1999;96(1):13-23.
1999: Ho I C; Kim J I; Szabo S J; Glimcher L H
Tissue-specific regulation of cytokine gene expression.
Cold Spring Harbor symposia on quantitative biology 1999;64():573-84.
1998: Ho I C; Kim J H; Rooney J W; Spiegelman B M; Glimcher L H
A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15537-41.
1998: Ranger A M; Oukka M; Rengarajan J; Glimcher L H
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.
Immunity 1998;9(5):627-35.
1998: Ho I C; Lo D; Glimcher L H
c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms.
The Journal of experimental medicine 1998;188(10):1859-66.
1998: Oukka M; Ho I C; de la Brousse F C; Hoey T; Grusby M J; Glimcher L H
The transcription factor NFAT4 is involved in the generation and survival of T cells.
Immunity 1998;9(3):295-304.
1998: Ranger A M; Grusby M J; Hodge M R; Gravallese E M; de la Brousse F C; Hoey T; Mickanin C; Baldwin H S; Glimcher L H
The transcription factor NF-ATc is essential for cardiac valve formation.
Nature 1998;392(6672):186-90.
1998: Ranger A M; Hodge M R; Gravallese E M; Oukka M; Davidson L; Alt F W; de la Brousse F C; Hoey T; Grusby M; Glimcher L H
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.
Immunity 1998;8(1):125-34.
1998: Sabatine M S; Laufer T; Glimcher L H; Widmer M; Winn H; Auchincloss H
Delayed rejection of soluble tumor necrosis factor receptor-secreting tumor allografts.
Transplantation 1998;65(1):113-20.
1997: Laufer T M; Smiley S T; Ranger A; Clements V K; Ostrand-Rosenberg S; Glimcher L H
Single amino acid mutations in the murine MHC class II A beta cytoplasmic domain abrogate antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5914-20.
1997: Szabo S J; Glimcher L H; Ho I C
Genes that regulate interleukin-4 expression in T cells.
Current opinion in immunology 1997;9(6):776-81.
1997: Douhan J; Lieberson R; Knoll J H; Zhou H; Glimcher L H
An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator.
The Journal of experimental medicine 1997;185(11):1885-95.
1997: Zhou H; Su H S; Zhang X; Douhan J; Glimcher L H
CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4741-9.
1997: Lee R S; Grusby M J; Laufer T M; Colvin R; Glimcher L H; Auchincloss H
CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts.
Transplantation 1997;63(8):1123-33.
1996: Hodge M R; Chun H J; Rengarajan J; Alt A; Lieberson R; Glimcher L H
NF-AT-Driven interleukin-4 transcription potentiated by NIP45.
Science (New York, N.Y.) 1996;274(5294):1903-5.
1996: Brown J A; Titus R G; Nabavi N; Glimcher L H
Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response.
The Journal of infectious diseases 1996;174(6):1303-8.
1996: Ranger A M; Das M P; Kuchroo V K; Glimcher L H
B7-2 (CD86) is essential for the development of IL-4-producing T cells.
International immunology 1996;8(10):1549-60.
1996: Laufer T M; DeKoning J; Markowitz J S; Lo D; Glimcher L H
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex.
Nature 1996;383(6595):81-5.
1996: Ho I C; Hodge M R; Rooney J W; Glimcher L H
The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.
Cell 1996;85(7):973-83.
1996: Clauss I M; Chu M; Zhao J L; Glimcher L H
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core.
Nucleic acids research 1996;24(10):1855-64.
1996: Baskar S; Clements V K; Glimcher L H; Nabavi N; Ostrand-Rosenberg S
Rejection of MHC class II-transfected tumor cells requires induction of tumor-encoded B7-1 and/or B7-2 costimulatory molecules.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):3821-7.
1996: Hodge M R; Ranger A M; Charles de la Brousse F; Hoey T; Grusby M J; Glimcher L H
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.
Immunity 1996;4(4):397-405.
1996: Zhao J; Freeman G J; Gray G S; Nadler L M; Glimcher L H
A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB.
The Journal of experimental medicine 1996;183(3):777-89.
1996: Douhan J; Hauber I; Eibl M M; Glimcher L H
Genetic evidence for a new type of major histocompatibility complex class II combined immunodeficiency characterized by a dyscoordinate regulation of HLA-D alpha and beta chains.
The Journal of experimental medicine 1996;183(3):1063-9.
1996: Douhan J; Brown J A; Gleit Z L; David C S; Glimcher L H
Regulation of the E beta gene in vivo: lessons from E beta d transgenic mice.
International immunology 1996;8(2):255-65.
1996: Steele D J; Laufer T M; Smiley S T; Ando Y; Grusby M J; Glimcher L H; Auchincloss H
Two levels of help for B cell alloantibody production.
The Journal of experimental medicine 1996;183(2):699-703.
1996: Reimold A M; Ponath P D; Li Y S; Hardy R R; David C S; Strominger J L; Glimcher L H
Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.
The Journal of experimental medicine 1996;183(2):393-401.
1996: Smiley S T; Rudensky A Y; Glimcher L H; Grusby M J
Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):241-4.
1996: Reimold A M; Grusby M J; Kosaras B; Fries J W; Mori R; Maniwa S; Clauss I M; Collins T; Sidman R L; Glimcher M J; Glimcher L H
Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice.
Nature 1996;379(6562):262-5.
1995: Rooney J W; Sun Y L; Glimcher L H; Hoey T
Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation.
Molecular and cellular biology 1995;15(11):6299-310.
1995: Hodge M R; Rooney J W; Glimcher L H
The proximal promoter of the IL-4 gene is composed of multiple essential regulatory sites that bind at least two distinct factors.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6397-405.
1995: Chakkalath H R; Theodos C M; Markowitz J S; Grusby M J; Glimcher L H; Titus R G
Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease.
The Journal of infectious diseases 1995;171(5):1302-8.
1995: Zhou H; Glimcher L H
Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency.
Immunity 1995;2(5):545-53.
1995: Rooney J W; Hoey T; Glimcher L H
Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene.
Immunity 1995;2(5):473-83.
1995: Smiley S T; Laufer T M; Lo D; Glimcher L H; Grusby M J
Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation.
International immunology 1995;7(4):665-77.
1995: Kuchroo V K; Das M P; Brown J A; Ranger A M; Zamvil S S; Sobel R A; Weiner H L; Nabavi N; Glimcher L H
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.
Cell 1995;80(5):707-18.
1995: Ruderman E M; Kerr J S; Telford S R; Spielman A; Glimcher L H; Gravallese E M
Early murine Lyme carditis has a macrophage predominance and is independent of major histocompatibility complex class II-CD4+ T cell interactions.
The Journal of infectious diseases 1995;171(2):362-70.
1995: Baskar S; Glimcher L; Nabavi N; Jones R T; Ostrand-Rosenberg S
Major histocompatibility complex class II+B7-1+ tumor cells are potent vaccines for stimulating tumor rejection in tumor-bearing mice.
The Journal of experimental medicine 1995;181(2):619-29.
1995: Grusby M J; Glimcher L H
Immune responses in MHC class II-deficient mice.
Annual review of immunology 1995;13():417-35.
1994: Avery A C; Markowitz J S; Grusby M J; Glimcher L H; Cantor H
Activation of T cells by superantigen in class II-negative mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):4853-61.
1994: Darling J M; Glimcher L H; Shortkroff S; Albano B; Gravallese E M
Expression of metalloproteinases in pigmented villonodular synovitis.
Human pathology 1994;25(8):825-30.
1994: Mombaerts P; Mizoguchi E; Ljunggren H G; Iacomini J; Ishikawa H; Wang L; Grusby M J; Glimcher L H; Winn H J; Bhan A K
Peripheral lymphoid development and function in TCR mutant mice.
International immunology 1994;6(7):1061-70.
1994: Linette G P; Grusby M J; Hedrick S M; Hansen T H; Glimcher L H; Korsmeyer S J
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.
Immunity 1994;1(3):197-205.
1994: Degermann S; Surh C D; Glimcher L H; Sprent J; Lo D
B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3254-63.
1994: Lee R S; Grusby M J; Glimcher L H; Winn H J; Auchincloss H
Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.
The Journal of experimental medicine 1994;179(3):865-72.
1994: Rooney J W; Hodge M R; McCaffrey P G; Rao A; Glimcher L H
A common factor regulates both Th1- and Th2-specific cytokine gene expression.
The EMBO journal 1994;13(3):625-33.
1994: Lederer J A; Liou J S; Todd M D; Glimcher L H; Lichtman A H
Regulation of cytokine gene expression in T helper cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(1):77-86.
1994: Ivashkiv L B; Ayres A; Glimcher L H
Inhibition of IFN-gamma induction of class II MHC genes by cAMP and prostaglandins.
Immunopharmacology 1994;27(1):67-77.
1993: Crump A L; Grusby M J; Glimcher L H; Cantor H
Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10739-43.
1993: Reimold A M; Kara C J; Rooney J W; Glimcher L H
Transforming growth factor beta 1 repression of the HLA-DR alpha gene is mediated by conserved proximal promoter elements.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4173-82.
1993: Baskar S; Nabavi N; Glimcher L H; Ostrand-Rosenberg S
Tumor cells expressing major histocompatibility complex class II and B7 activation molecules stimulate potent tumor-specific immunity.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(3):209-15.
1993: Mombaerts P; Mizoguchi E; Grusby M J; Glimcher L H; Bhan A K; Tonegawa S
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice.
Cell 1993;75(2):274-82.
1993: Ponath P D; Fass D; Liou H C; Glimcher L H; Strominger J L
The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes.
The Journal of biological chemistry 1993;268(23):17074-82.
1993: Laufer T M; von Herrath M G; Grusby M J; Oldstone M B; Glimcher L H
Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice.
The Journal of experimental medicine 1993;178(2):589-96.
1993: Todd M D; Grusby M J; Lederer J A; Lacy E; Lichtman A H; Glimcher L H
Transcription of the interleukin 4 gene is regulated by multiple promoter elements.
The Journal of experimental medicine 1993;177(6):1663-74.
1993: Kara C J; Glimcher L H
Developmental and cytokine-mediated regulation of MHC class II gene promoter occupancy in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):4934-42.
1993: Jevnikar A M; Singer G G; Coffman T; Glimcher L H; Kelley V E
Transgenic tubular cell expression of class II is insufficient to initiate immune renal injury.
Journal of the American Society of Nephrology : JASN 1993;3(12):1972-7.
1993: Clauss I M; Gravallese E M; Darling J M; Shapiro F; Glimcher M J; Glimcher L H
In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1993;197(2):146-56.
1993: Baskar S; Ostrand-Rosenberg S; Nabavi N; Nadler L M; Freeman G J; Glimcher L H
Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5687-90.
1993: Grusby M J; Auchincloss H; Lee R; Johnson R S; Spencer J P; Zijlstra M; Jaenisch R; Papaioannou V E; Glimcher L H
Mice lacking major histocompatibility complex class I and class II molecules.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3913-7.
1993: Markowitz J S; Auchincloss H; Grusby M J; Glimcher L H
Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2779-83.
1993: Jevnikar A M; Singer G G; Coffman T; Glimcher L H; Kelley V E
Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney transplant model.
Transplantation proceedings 1993;25(1 Pt 1):142-3.
1993: Markowitz J S; Rogers P R; Grusby M J; Parker D C; Glimcher L H
B lymphocyte development and activation independent of MHC class II expression.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1223-33.
1993: Kara C J; Glimcher L H
Promoter accessibility within the environment of the MHC is affected in class II-deficient combined immunodeficiency.
The EMBO journal 1993;12(1):187-93.
1993: Kara C J; Glimcher L H
Three in vivo promoter phenotypes in MHC class II deficient combined immunodeficiency.
Immunogenetics 1993;37(3):227-30.
1992: Ivashkiv L B; Fleming M D; Glimcher L H
Dominant negative mutants of transcription factor mXBP (CRE-BP1, ATF-2).
The New biologist 1992;4(4):360-8.
1992: Glimcher L H; Kara C J
Sequences and factors: a guide to MHC class-II transcription.
Annual review of immunology 1992;10():13-49.
1991: Ivashkiv L B; Glimcher L H
Repression of class II major histocompatibility complex genes by cyclic AMP is mediated by conserved promoter elements.
The Journal of experimental medicine 1991;174(6):1583-92.
1991: Gravallese E M; Darling J M; Glimcher L H; Boothby M
Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(7):2377-83.
1991: Whitley M Z; Sisk R; Ivashkiv L B; Finn P W; Glimcher L H; Boothby M R
Non-consensus DNA sequences function in a cell-type-specific enhancer of the mouse class II MHC gene A alpha.
International immunology 1991;3(9):877-88.
1991: Grusby M J; Johnson R S; Papaioannou V E; Glimcher L H
Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.
Science (New York, N.Y.) 1991;253(5026):1417-20.
1991: Gravallese E M; Darling J M; Ladd A L; Katz J N; Glimcher L H
In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium.
Arthritis and rheumatism 1991;34(9):1076-84.
1991: Jevnikar A M; Brennan D C; Singer G G; Heng J E; Maslinski W; Wuthrich R P; Glimcher L H; Kelley V E
Stimulated kidney tubular epithelial cells express membrane associated and secreted TNF alpha.
Kidney international 1991;40(2):203-11.
1991: Finn P W; Kara C J; Grusby M J; Folsom V; Glimcher L H
Upstream elements of the MHC class II E beta gene active in B cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(11):4011-5.
1991: Ono S J; Liou H C; Davidon R; Strominger J L; Glimcher L H
Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4309-12.
1991: Kara C J; Glimcher L H
In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome.
Science (New York, N.Y.) 1991;252(5006):709-12.
1991: Kara C J; Glimcher L H
Regulation of MHC class II gene transcription.
Current opinion in immunology 1991;3(1):16-21.
1991: Jevnikar A M; Wuthrich R P; Brennan D C; Maslinski W; Glimcher L H; Rubin-Kelley V E
TNF-alpha is expressed on the surface of kidney proximal tubular cells.
Transplantation proceedings 1991;23(1 Pt 1):231-2.
1991: Liou H C; Eddy R; Shows T; Lisowska-Grospierre B; Griscelli C; Doyle C; Mannhalter J; Eibl M; Glimcher L H
An HLA-DR alpha promoter DNA-binding protein is expressed ubiquitously and maps to human chromosomes 22 and 5.
Immunogenetics 1991;34(5):286-92.
1990: Grusby M J; Mitchell S C; Nabavi N; Glimcher L H
Casein expression in cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6897-901.
1990: Jevnikar A M; Wuthrich R P; Takei F; Xu H W; Brennan D C; Glimcher L H; Rubin-Kelley V E
Differing regulation and function of ICAM-1 and class II antigens on renal tubular cells.
Kidney international 1990;38(3):417-25.
1990: Fontaine B; Hanson M P; Liou H C; Glimcher L H; Rouleau G A; Gusella J F
BanI polymorphism at the XBP1 locus.
Nucleic acids research 1990;18(18):5578.
1990: Grusby M J; Mitchell S C; Glimcher L H
Molecular cloning of mouse cathepsin D.
Nucleic acids research 1990;18(13):4008.
1990: Finn P W; Van T T; Accolla R S; Glimcher L H
Loss of a DNA-protein complex correlates with extinguished major histocompatibility complex class II expression in a human B cell.
The Journal of experimental medicine 1990;171(6):2159-64.
1990: Finn P W; Kara C J; Van T T; Douhan J; Boothby M R; Glimcher L H
The presence of a DNA binding complex correlates with E beta class II MHC gene expression.
The EMBO journal 1990;9(5):1543-9.
1990: Kara C J; Liou H C; Ivashkiv L B; Glimcher L H
A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.
Molecular and cellular biology 1990;10(4):1347-57.
1990: Ivashkiv L B; Liou H C; Kara C J; Lamph W W; Verma I M; Glimcher L H
mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.
Molecular and cellular biology 1990;10(4):1609-21.
1990: Liou H C; Boothby M R; Finn P W; Davidon R; Nabavi N; Zeleznik-Le N J; Ting J P; Glimcher L H
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.
Science (New York, N.Y.) 1990;247(4950):1581-4.
1990: Wuthrich R P; Glimcher L H; Yui M A; Jevnikar A M; Dumas S E; Kelley V E
MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells.
Kidney international 1990;37(2):783-92.
1990: Grusby M J; Nabavi N; Wong H; Dick R F; Bluestone J A; Schotz M C; Glimcher L H
Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.
Cell 1990;60(3):451-9.
1990: Finn P W; Kara C J; Douhan J; Van T T; Folsom V; Glimcher L H
Interferon gamma regulates binding of two nuclear protein complexes in a macrophage cell line.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):914-8.
1990: Wuthrich R P; Jevnikar A M; Takei F; Glimcher L H; Kelley V E
Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis.
The American journal of pathology 1990;136(2):441-50.
1990: Boothby M; Liou H C; Finn P W; Gravallese E; Glimcher L H
Control of transcription at the murine A alpha locus.
Immunologic research 1990;9(2):77-92.
1990: Nabavi N; Grusby M J; Finn P W; Wolgemuth D J; Glimcher L H
Identification of an IL-4-inducible gene expressed in differentiating lymphocytes and male germ cells.
Developmental immunology 1990;1(1):19-30.
1989: Ghogawala Z; Choi E; Daly K R; Blanco L R; Griffith I J; Glimcher L H
An intronic 10-base-pair deletion in a class II A beta gene affects RNA processing.
Molecular and cellular biology 1989;9(10):4402-8.
1989: Gravallese E M; Boothby M R; Smas C M; Glimcher L H
A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B.
Molecular and cellular biology 1989;9(8):3184-92.
1989: St-Pierre Y; Nabavi N; Ghogawala Z; Glimcher L H; Watts T H
A functional role for signal transduction via the cytoplasmic domains of MHC class II proteins.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):808-12.
1989: Johnson N A; Carland F; Allen P M; Glimcher L H
T cell receptor gene segment usage in a panel of hen-egg white lysozyme specific, I-Ak-restricted T helper hybridomas.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3298-304.
1989: Nabavi N; Ghogawala Z; Myer A; Griffith I J; Wade W F; Chen Z Z; McKean D J; Glimcher L H
Antigen presentation abrogated in cells expressing truncated Ia molecules.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(5):1444-7.
1989: Boothby M; Liou H C; Glimcher L H
Differences in DNA sequence specificity among MHC class II X box binding proteins.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(3):1005-14.
1989: Wuthrich R P; Yui M A; Mazoujian G; Nabavi N; Glimcher L H; Kelley V E
Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis.
The American journal of pathology 1989;134(1):45-51.
1988: Boothby M; Gravallese E; Liou H C; Glimcher L H
A DNA binding protein regulated by IL-4 and by differentiation in B cells.
Science (New York, N.Y.) 1988;242(4885):1559-62.
1988: Liou H C; Boothby M R; Glimcher L H
Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element.
Science (New York, N.Y.) 1988;242(4875):69-71.
1988: Griffith I J; Ghogawala Z; Nabavi N; Golan D E; Myer A; McKean D J; Glimcher L H
Cytoplasmic domain affects membrane expression and function of an Ia molecule.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4847-51.
1988: Liou H C; Polla B S; Aragnol D; Leserman L D; Griffith I J; Glimcher L H
A tissue-specific DNase I-hypersensitive site in a class II A alpha gene is under trans-regulatory control.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2738-42.
1988: Griffith I J; Nabavi N; Ghogawala Z; Chase C G; Rodriguez M; McKean D J; Glimcher L H
Structural mutation affecting intracellular transport and cell surface expression of murine class II molecules.
The Journal of experimental medicine 1988;167(2):541-55.
1988: Polla B S; Ohara J; Paul W E; Nabavi N; Myer A; Liou H C; Shen F W; Gillis S; Bonventre J V; Glimcher L H
Differential induction of class II gene expression in murine pre-B-cell lines by B-cell stimulatory factor-1 and by antibodies to B-cell surface antigens.
The Journal of molecular and cellular immunology : JMCI 1988;3(6):363-73.

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