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Peter Gmeiner

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Cornelia Held; Harald Hübner; Ralf Kling; Yvonne A Nagel; Helma Wennemers; Peter Gmeiner
Impact of the Proline Residue on Ligand Binding of Neurotensin Receptor 2 (NTS2)-Selective Peptide-Peptoid Hybrids.
Oliver Welzel; Peter Gmeiner; Johannes Kornhuber; Kristina Loy; Alina Tabor; Carsten H Tischbirek; Teja Wolfgang Groemer
The pH Probe CypHer™5E is Effectively Quenched by FM Dyes.
Fabrizio Sanna; Nuska Tschammer; Harald Hübner; Stefan Löber; Birgit Ortner; Peter Gmeiner
Discovery of dopamine D₄ receptor antagonists with planar chirality.

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2013: Cornelia Held; Harald Hübner; Ralf Kling; Yvonne A Nagel; Helma Wennemers; Peter Gmeiner
Impact of the Proline Residue on Ligand Binding of Neurotensin Receptor 2 (NTS2)-Selective Peptide-Peptoid Hybrids.
ChemMedChem 2013;8(5):772-8.
2013: Oliver Welzel; Peter Gmeiner; Johannes Kornhuber; Kristina Loy; Alina Tabor; Carsten H Tischbirek; Teja Wolfgang Groemer
The pH Probe CypHer™5E is Effectively Quenched by FM Dyes.
Journal of fluorescence 2013;23(3):487-94.
2013: Fabrizio Sanna; Nuska Tschammer; Harald Hübner; Stefan Löber; Birgit Ortner; Peter Gmeiner
Discovery of dopamine D₄ receptor antagonists with planar chirality.
Bioorganic & medicinal chemistry 2013;21(7):1680-4.
2013: Cornelia Held; Harald Hübner; Jasmin Meltretter; Monika Pischetsrieder; Manuel Plomer; Peter Gmeiner
Development of a metabolically stable neurotensin receptor 2 (NTS2) ligand.
ChemMedChem 2013;8(1):75-81.
2012: Stefan Löber; Maria Rosaria Melis; Fabrizio Sanna; Antonio Argiolas; Armin Buschauer; Harald Hübner; Peter Gmeiner
Novel azulene derivatives for the treatment of erectile dysfunction.
Bioorganic & medicinal chemistry letters 2012;22(23):7151-4.
2012: Susanne Koschatzky; Peter Gmeiner
Selective agonists for dopamine/neurotensin receptor heterodimers.
ChemMedChem 2012;7(3):509-14.
2011: Angela Goetz; Harald Lanig; Peter Gmeiner; Timothy Clark
Molecular dynamics simulations of the effect of the G-protein and diffusible ligands on the β2-adrenergic receptor.
Journal of molecular biology 2011;414(4):611-23.
2011: Julia Kühhorn; Dawn Thompson; Jennifer Whistler; Andreas W Götz; Harald Hübner; Peter Gmeiner
Development of a bivalent dopamine D₂ receptor agonist.
Journal of medicinal chemistry 2011;54(22):7911-9.
2011: Julia Kühhorn; Harald Hübner; Peter Gmeiner
Bivalent dopamine D2 receptor ligands: synthesis and binding properties.
Journal of medicinal chemistry 2011;54(13):4896-903.
2011: Andrea Pinsker; Reiner Waibel; Jürgen Einsiedel; Steffen Härterich; Peter Gmeiner
A highly efficient type I β-turn mimetic simulating an Asx-Pro-turn-like structure.
Organic letters 2011;13(13):3502-5.
2011: Alexandra Kekewska; Peter Gmeiner; Harald Hübner; Heinz H Pertz
The bulky N6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-HT2A and 5-HT2B receptors and thus is a determinant of valvular heart disease.
The Journal of pharmacology and experimental therapeutics 2011;338(1):381-91.
2011: Susanne Koschatzky; Nuska Tschammer; Peter Gmeiner
Cross-receptor interactions between dopamine D(2L) and neurotensin NTS(1) receptors modulate binding affinities of dopaminergics.
ACS chemical neuroscience 2011;2(6):308-16.
2011: Gerald Pratsch; Johannes F Unfried; Jürgen Einsiedel; Manuel Plomer; Harald Hübner; Peter Gmeiner; Markus R Heinrich
Radical arylation of tyrosine and its application in the synthesis of a highly selective neurotensin receptor 2 ligand.
Organic & biomolecular chemistry 2011;9(10):3746-52.
2011: Jürgen Einsiedel; Cornelia Held; Maud Hervet; Harald Hübner; Manuel Plomer; Nuska Tschammer; Peter Gmeiner
Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics.
Journal of medicinal chemistry 2011;54(8):2915-23.
2011: Nuska Tschammer; Jan Elsner; Angela Goetz; Katharina Ehrlich; Stefan Schuster; Miriam Ruberg; Julia Kühhorn; Dawn Thompson; Jennifer Whistler; Harald Hübner; Peter Gmeiner
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Journal of medicinal chemistry 2011;54(7):2477-91.
2011: Stefan Löber; Harald Hübner; Nuska Tschammer; Peter Gmeiner
Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates.
Trends in pharmacological sciences 2011;32(3):148-57.
2011: Nuska Tschammer; Stefan Bollinger; Terry Kenakin; Peter Gmeiner
Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor.
Molecular pharmacology 2011;79(3):575-85.
2011: Gerd Meyer zu Hörste; Johanna I Müller; Olaf Stüve; Peter Gmeiner; Hans-Peter Hartung; Carsten Korth; Helmar C Lehmann; Stefan Löber; Anne K Mausberg; Bernd C Kieseier
Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules.
PloS one 2011;6(6):e21223.
2010: S B Höfling; Simone Maschauer; Harald Hübner; Peter Gmeiner; Hans-Jürgen Wester; Olaf Prante; M R Heinrich
Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.
Bioorganic & medicinal chemistry letters 2010;20(23):6933-7.
2010: Stefan Bollinger; Harald Hübner; Frank W Heinemann; Karsten Meyer; Peter Gmeiner
Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists.
Journal of medicinal chemistry 2010;53(19):7167-79.
2010: Marika Skultety; Harald Hübner; Stefan Löber; Peter Gmeiner
Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors.
Journal of medicinal chemistry 2010;53(19):7219-28.
2010: Susanne Lochner; Jürgen Einsiedel; Gesa Schaefer; Christian Berens; Wolfgang Hillen; Peter Gmeiner
Anhydrotetracycline-peptide conjugates as representatives for ligand-based transactivating systems.
Bioorganic & medicinal chemistry 2010;18(16):6127-33.
2010: Carsten Hocke; Simone Maschauer; Harald Hübner; Stefan Löber; Wolfgang Utz; Torsten Kuwert; Peter Gmeiner; Olaf Prante
A series of 18F-labelled pyridinylphenyl amides as subtype-selective radioligands for the dopamine D3 receptor.
ChemMedChem 2010;5(6):941-8.
2010: Igor Usai; Marcus Krueger; Jürgen Einsiedel; Wolfgang Hillen; Peter Gmeiner
Click-chemistry-derived tetracycline-amino acid conjugates exhibiting exceptional potency and exclusive recognition of the reverse tet repressor.
Chembiochem : a European journal of chemical biology 2010;11(5):703-12.
2010: Nuska Tschammer; Harald Hübner; Miriam Dörfler; Peter Gmeiner
Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine.
ACS chemical neuroscience 2010;1(1):25-35.
2010: Simone Maschauer; Jürgen Einsiedel; Roland Haubner; Carsten Hocke; Matthias Ocker; Harald Hübner; Torsten Kuwert; Peter Gmeiner; Olaf Prante
Labeling and glycosylation of peptides using click chemistry: a general approach to (18)F-glycopeptides as effective imaging probes for positron emission tomography.
Angewandte Chemie (International ed. in English) 2010;49(5):976-9.
2009: Christian Kormann; Irina Pimenta; Stefan Löber; Cornelius Wimmer; Harald Lanig; Timothy Clark; Wolfgang Hillen; Peter Gmeiner
Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations.
Chembiochem : a European journal of chemical biology 2009;10(18):2924-33.
2009: Daniela Huber; Harald Hübner; Peter Gmeiner
1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands.
Journal of medicinal chemistry 2009;52(21):6860-70.
2009: Michael Alexander Klieber; Oliver Scholz; Susanne Lochner; Peter Gmeiner; Wolfgang Hillen; Yves A Muller
Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair.
The FEBS journal 2009;276(19):5610-21.
2009: Katharina Ehrlich; Andreas W Götz; Stefan Bollinger; Nuska Tschammer; Laura Bettinetti; Steffen Härterich; Harald Hübner; Harald Lanig; Peter Gmeiner
Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
Journal of medicinal chemistry 2009;52(15):4923-35.
2009: Pilar Rodriguez Loaiza; Stefan Löber; Harald Hübner; Peter Gmeiner
Parallel synthesis of potent dopaminergic N-phenyltriazole carboxamides applying a novel click chemistry based phenol linker.
Bioorganic & medicinal chemistry 2009;17(15):5482-7.
2009: Sabine Linz; Jörg Müller; Harald Hübner; Peter Gmeiner; Reinhard Troschütz
Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.
Bioorganic & medicinal chemistry 2009;17(13):4448-58.
2009: Stefan Löber; Nuska Tschammer; Harald Hübner; Maria Rosaria Melis; Antonio Argiolas; Peter Gmeiner
The azulene framework as a novel arene bioisostere: design of potent dopamine D4 receptor ligands inducing penile erection.
ChemMedChem 2009;4(3):325-8.
2008: Miriam Dörfler; Nuska Tschammer; Katharina Hamperl; Harald Hübner; Peter Gmeiner
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Journal of medicinal chemistry 2008;51(21):6829-38.
2008: Steffen Härterich; Susanne Koschatzky; Jürgen Einsiedel; Peter Gmeiner
Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1.
Bioorganic & medicinal chemistry 2008;16(20):9359-68.
2008: Luelak Lomlim; Jürgen Einsiedel; Frank W Heinemann; Karsten Meyer; Peter Gmeiner
Proline derived spirobarbiturates as highly effective beta-turn mimetics incorporating polar and functionalizable constraint elements.
The Journal of organic chemistry 2008;73(9):3608-11.
2008: Carsten Hocke; Olaf Prante; Ismael Salama; Harald Hübner; Stefan Löber; Torsten Kuwert; Peter Gmeiner
18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor.
ChemMedChem 2008;3(5):788-93.
2008: Rodrigo M Pádua; Reiner Waibel; Serge Philibert Kuate; Pia K Schebitz; Stefanie Hahn; Peter Gmeiner; Wolfgang Kreis
A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxypregnanes, potential intermediates in cardenolide biosynthesis.
Steroids 2008;73(4):458-65.
2008: Olaf Prante; Rainer Tietze; Carsten Hocke; Stefan Löber; Harald Hübner; Torsten Kuwert; Peter Gmeiner
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.
Journal of medicinal chemistry 2008;51(6):1800-10.
2008: Jürgen Einsiedel; Harald Hübner; Maud Hervet; Steffen Härterich; Susanne Koschatzky; Peter Gmeiner
Peptide backbone modifications on the C-terminal hexapeptide of neurotensin.
Bioorganic & medicinal chemistry letters 2008;18(6):2013-8.
2008: Tilo Görnemann; Harald Hübner; Peter Gmeiner; Reinhard Horowski; Klaus Peter Latté; Miroslav Flieger; Heinz H Pertz
Characterization of the molecular fragment that is responsible for agonism of pergolide at serotonin 5-Hydroxytryptamine2B and 5-Hydroxytryptamine2A receptors.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1136-45.
2008: Rainer Tietze; Stefan Löber; Harald Hübner; Peter Gmeiner; Torsten Kuwert; Olaf Prante
Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker.
Bioorganic & medicinal chemistry letters 2008;18(3):983-8.
2007: Pilar Rodriguez Loaiza; Stefan Löber; Harald Hübner; Peter Gmeiner
Click chemistry based solid phase supported synthesis of dopaminergic phenylacetylenes.
Bioorganic & medicinal chemistry 2007;15(23):7248-57.
2007: Jürgen Einsiedel; Harald Lanig; Reiner Waibel; Peter Gmeiner
Molecular building kit of fused-proline-derived peptide mimetics allowing specific adjustment of the dihedral Psi angle.
The Journal of organic chemistry 2007;72(24):9102-13.
2007: Daniela Stark; Markus Piel; Harald Hübner; Peter Gmeiner; Gerhard Gründer; Frank Rösch
In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors.
Bioorganic & medicinal chemistry 2007;15(21):6819-29.
2007: Frank Boeckler; Peter Gmeiner
Dopamine D3 receptor ligands: recent advances in the control of subtype selectivity and intrinsic activity.
Biochimica et biophysica acta 2007;1768(4):871-87.
2007: Ismail Salama; Carsten Hocke; Wolfgang Utz; Olaf Prante; Frank Boeckler; Harald Hübner; Torsten Kuwert; Peter Gmeiner
Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands.
Journal of medicinal chemistry 2007;50(3):489-500.
2007: Olaf Prante; Jürgen Einsiedel; Roland Haubner; Peter Gmeiner; Hans-Jürgen Wester; Torsten Kuwert; Simone Maschauer
3,4,6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl phenylthiosulfonate: a thiol-reactive agent for the chemoselective 18F-glycosylation of peptides.
Bioconjugate chemistry 2007;18(1):254-62.
2006: Olaf G Othersen; Reiner Waibel; Harald Lanig; Peter Gmeiner; Timothy Clark
SCRF-DFT and NMR comparison of tetracycline and 5a,6-anhydrotetracycline in solution.
The journal of physical chemistry. B 2006;110(48):24766-74.
2006: Silke Dollinger; Stefan Löber; Ralf Klingenstein; Carsten Korth; Peter Gmeiner
A chimeric ligand approach leading to potent antiprion active acridine derivatives: design, synthesis, and biological investigations.
Journal of medicinal chemistry 2006;49(22):6591-5.
2006: Maria Rosaria Melis; Salvatora Succu; Fabrizio Sanna; Tiziana Melis; Maria Stefania Mascia; Cécile Enguehard-Gueiffier; Harald Hubner; Peter Gmeiner; Alain Gueiffier; Antonio Argiolas
PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain.
The European journal of neuroscience 2006;24(7):2021-30.
2006: Frank Boeckler; Peter Gmeiner
The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects.
Pharmacology & therapeutics 2006;112(1):281-333.
2006: Christian Berens; Susanne Lochner; Stefan Löber; Igor Usai; Andreas Schmidt; Lars Drueppel; Wolfgang Hillen; Peter Gmeiner
Subtype selective tetracycline agonists and their application for a two-stage regulatory system.
Chembiochem : a European journal of chemical biology 2006;7(9):1320-4.
2006: Ismail Salama; Karin Schlotter; Wolfgang Utz; Harald Hübner; Peter Gmeiner; Frank Boeckler
CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues.
Bioorganic & medicinal chemistry 2006;14(17):5898-912.
2006: Holger Bittermann; Frank Böckler; Jürgen Einsiedel; Peter Gmeiner
A highly practical RCM approach towards a molecular building kit of spirocyclic reverse turn mimics.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(24):6315-22.
2006: Christel Krueger; Christina Danke; Klaus Pfleiderer; Wolfgang Schuh; Hans-Martin Jäck; Susanne Lochner; Peter Gmeiner; Wolfgang Hillen; Christian Berens
A gene regulation system with four distinct expression levels.
The journal of gene medicine 2006;8(8):1037-47.
2006: Ralf Klingenstein; Stefan Löber; Pekka Kujala; Susan Godsave; S Rutger Leliveld; Peter Gmeiner; Peter J Peters; Carsten Korth
Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments.
Journal of neurochemistry 2006;98(3):748-59.
2006: Cécile Enguehard-Gueiffier; Harald Hübner; Ahmed El Hakmaoui; Hassan Allouchi; Peter Gmeiner; Antonio Argiolas; Maria Rosaria Melis; Alain Gueiffier
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.
Journal of medicinal chemistry 2006;49(13):3938-47.
2006: Karin Schlotter; Frank Boeckler; Harald Hübner; Peter Gmeiner
Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists.
Journal of medicinal chemistry 2006;49(12):3628-35.
2006: Stefan Löber; Harald Hübner; Peter Gmeiner
Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype.
Bioorganic & medicinal chemistry letters 2006;16(11):2955-9.
2006: Jan Elsner; Frank Boeckler; Kathryn Davidson; David Sugden; Peter Gmeiner
Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation.
Bioorganic & medicinal chemistry 2006;14(6):1949-58.
2006: Pilar Rodriguez Loaiza; Stefan Löber; Harald Hübner; Peter Gmeiner
Click chemistry on solid phase: parallel synthesis of N-benzyltriazole carboxamides as super-potent G-protein coupled receptor ligands.
Journal of combinatorial chemistry 2006;8(2):252-61.
2006: Holger Bittermann; Peter Gmeiner
Chirospecific synthesis of spirocyclic beta-lactams and their characterization as potent type II beta-turn inducing peptide mimetics.
The Journal of organic chemistry 2006;71(1):97-102.
2006: Olaf Prante; Carsten Hocke; Stefan Löber; Harald Hübner; Peter Gmeiner; Torsten Kuwert
Tissue distribution of radioiodinated FAUC113: assessment of a pyrazolo(1,5-a) pyridine based dopamine D4 receptor radioligand candidate.
Nuklearmedizin. Nuclear medicine 2006;45(1):41-8.
2005: Carsten Hocke; Olaf Prante; Stefan Löber; Harald Hübner; Peter Gmeiner; Torsten Kuwert
Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents.
Bioorganic & medicinal chemistry letters 2005;15(21):4819-23.
2005: Jan Elsner; Frank Boeckler; Frank W Heinemann; Harald Hübner; Peter Gmeiner
Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.
Journal of medicinal chemistry 2005;48(18):5771-9.
2005: Carola Lenz; Frank Boeckler; Harald Hübner; Peter Gmeiner
Fancy bioisosteres: synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands.
Bioorganic & medicinal chemistry 2005;13(14):4434-42.
2005: Karin Schlotter; Frank Boeckler; Harald Hübner; Peter Gmeiner
Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles.
Journal of medicinal chemistry 2005;48(11):3696-9.
2005: Laura Bettinetti; Harald Hübner; Peter Gmeiner
Chirospecific and subtype selective dopamine receptor binding of heterocyclic methoxynaphthamide analogs.
Archiv der Pharmazie 2005;338(5-6):276-80.
2005: Frank Boeckler; Ursula Ohnmacht; Thomas Lehmann; Wolfgang Utz; Harald Hübner; Peter Gmeiner
CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists.
Journal of medicinal chemistry 2005;48(7):2493-508.
2005: Laura Bettinetti; Stefan Löber; Harald Hübner; Peter Gmeiner
Parallel synthesis and biological screening of dopamine receptor ligands taking advantage of a click chemistry based BAL linker.
Journal of combinatorial chemistry 2005;7(2):309-16.
2005: Frank Boeckler; Harald Lanig; Peter Gmeiner
Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes.
Journal of medicinal chemistry 2005;48(3):694-709.
2005: Carola Lenz; Christian Haubmann; Harald Hübner; Frank Boeckler; Peter Gmeiner
Fancy bioisosteres: synthesis and dopaminergic properties of the endiyne FAUC 88 as a novel non-aromatic D3 agonist.
Bioorganic & medicinal chemistry 2005;13(1):185-91.
2004: Holger Bittermann; Jürgen Einsiedel; Harald Hübner; Peter Gmeiner
Evaluation of lactam-bridged neurotensin analogues adjusting psi(Pro10) close to the experimentally derived bioactive conformation of NT(8-13).
Journal of medicinal chemistry 2004;47(22):5587-90.
2004: Carsten Hocke; Olaf Prante; Stefan Löber; Harald Hübner; Peter Gmeiner; Torsten Kuwert
Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype.
Bioorganic & medicinal chemistry letters 2004;14(15):3963-6.
2004: Frank Boeckler; Holger Russig; Weining Zhang; Stefan Löber; John A Schetz; Harald Hübner; Boris Ferger; Peter Gmeiner; Joram Feldon
FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia.
Psychopharmacology 2004;175(1):7-17.
2004: Eva-Maria Henssler; Oliver Scholz; Susanne Lochner; Peter Gmeiner; Wolfgang Hillen
Structure-based design of Tet repressor to optimize a new inducer specificity.
Biochemistry 2004;43(29):9512-8.
2004: Thomas Hussenether; Harald Hübner; Peter Gmeiner; Reinhard Troschütz
Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing.
Bioorganic & medicinal chemistry 2004;12(10):2625-37.
2004: Carola Lenz; Frank Boeckler; Harald Hübner; Peter Gmeiner
Analogues of FAUC 73 revealing new insights into the structural requirements of nonaromatic dopamine D3 receptor agonists.
Bioorganic & medicinal chemistry 2004;12(1):113-7.
2003: Jürgen Einsiedel; Klaus Weber; Christoph Thomas; Thomas Lehmann; Harald Hübner; Peter Gmeiner
Stereocontrolled dopamine receptor binding and subtype selectivity of clebopride analogues synthesized from aspartic acid.
Bioorganic & medicinal chemistry letters 2003;13(19):3293-6.
2003: Frank Boeckler; Andreas Leng; Anna Mura; Laura Bettinetti; Joram Feldon; Peter Gmeiner; Boris Ferger
Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity by the novel selective dopamine D3-receptor partial agonist FAUC 329 predominantly in the nucleus accumbens of mice.
Biochemical pharmacology 2003;66(6):1025-32.
2003: Stefan Löber; Pilar Rodriguez-Loaiza; Peter Gmeiner
Click linker: efficient and high-yielding synthesis of a new family of SPOS resins by 1,3-dipolar cycloaddition.
Organic letters 2003;5(10):1753-5.
2003: Jürgen Einsiedel; Harald Hübner; Peter Gmeiner
Cyclic amidines as benzamide bioisosteres: EPC synthesis and SAR studies leading to the selective dopamine D4 receptor agonist FAUC 312.
Bioorganic & medicinal chemistry letters 2003;13(5):851-4.
2003: Tobias Hoffmann; Reiner Waibel; Peter Gmeiner
A general approach to dehydro-Freidinger lactams: ex-chiral pool synthesis and spectroscopic evaluation as potential reverse turn inducers.
The Journal of organic chemistry 2003;68(1):62-9.
2002: Laura Bettinetti; Karin Schlotter; Harald Hübner; Peter Gmeiner
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Journal of medicinal chemistry 2002;45(21):4594-7.
2002: Stefan Löber; Harald Hübner; Peter Gmeiner
Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.
Bioorganic & medicinal chemistry letters 2002;12(17):2377-80.
2002: Markus Bergauer; Harald Hübner; Peter Gmeiner
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.
Bioorganic & medicinal chemistry letters 2002;12(15):1937-40.
2002: Annette Moll; Harald Hübner; Peter Gmeiner; Reinhard Troschütz
Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D(4)-ligands.
Bioorganic & medicinal chemistry 2002;10(6):1671-9.
2002: Stefan Löber; Tarek Aboul-Fadl; Harald Hübner; Peter Gmeiner
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.
Bioorganic & medicinal chemistry letters 2002;12(4):633-6.
2001: Thomas Lehmann; Harald Hübner; Peter Gmeiner
Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding.
Bioorganic & medicinal chemistry letters 2001;11(21):2863-6.
2001: Jürgen Einsiedel; Harald Hübner; Peter Gmeiner
Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).
Bioorganic & medicinal chemistry letters 2001;11(18):2533-6.
2001: Stefan Löber; Harald Hübner; Wolfgang Utz; Peter Gmeiner
Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).
Journal of medicinal chemistry 2001;44(17):2691-4.
2001: Harald Lanig; Wolfgang Utz; Peter Gmeiner
Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine.
Journal of medicinal chemistry 2001;44(8):1151-7.
2000: Harald Hübner; J Kraxner; Peter Gmeiner
Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.
Journal of medicinal chemistry 2000;43(23):4563-9.
2000: K Weber; Ursula Ohnmacht; Peter Gmeiner
Enantiopure 4- and 5-aminopiperidin-2-ones: regiocontrolled synthesis and conformational characterization as bioactive beta-turn mimetics.
The Journal of organic chemistry 2000;65(22):7406-16.
2000: Jürgen Einsiedel; Christoph Thomas; Harald Hübner; Peter Gmeiner
Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.
Bioorganic & medicinal chemistry letters 2000;10(17):2041-4.
2000: J Kraxner; Harald Hübner; Peter Gmeiner
Azepino- and diazepinoindoles: synthesis and dopamine receptor binding profiles.
Archiv der Pharmazie 2000;333(9):287-92.
2000: K Weber; S Kuklinski; Peter Gmeiner
Treatment of N,N-dibenzylamino alcohols with sulfonyl chloride leads to rearranged beta-chloro amines, precursors to beta-amino acids, and not to tetrahydroisoquinolines.
Organic letters 2000;2(5):647-9.
2000: Harald Hübner; Christian Haubmann; Wolfgang Utz; Peter Gmeiner
Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype.
Journal of medicinal chemistry 2000;43(4):756-62.
1999: Christian Haubmann; Harald Hübner; Peter Gmeiner
Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands.
Bioorganic & medicinal chemistry letters 1999;9(21):3143-6.
1999: Christian Haubmann; Harald Hübner; Peter Gmeiner
2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.
Bioorganic & medicinal chemistry letters 1999;9(14):1969-72.
1999: Ursula Ohnmacht; Christian Tränkle; Klaus Mohr; Peter Gmeiner
[3H]Pramipexole: a selective radioligand for the high affinity dopamine D2 receptor in bovine striatal membranes.
Die Pharmazie 1999;54(4):294-7.
1999: Christoph Thomas; Ursula Ohnmacht; K Zahn; Klaus Mohr; Peter Gmeiner
Ex-chiral pool synthesis and pharmacological aspects of 3-pyrrolidinylisoxazoles.
Die Pharmazie 1999;54(4):248-50.
1999: Christoph Thomas; Harald Hübner; Peter Gmeiner
Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid.
Bioorganic & medicinal chemistry letters 1999;9(6):841-6.
1999: Stefan Löber; Harald Hübner; Peter Gmeiner
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.
Bioorganic & medicinal chemistry letters 1999;9(1):97-102.
1998: Christoph Thomas; Ursula Ohnmacht; M Niger; Peter Gmeiner
Beta-analogs of PLG (L-prolyl-L-leucyl-glycinamide): ex-chiral pool syntheses and dopamine D2 receptor modulating effects.
Bioorganic & medicinal chemistry letters 1998;8(20):2885-90.
1995: Peter Gmeiner; A Kärtner; J Mierau
Synthesis and dopamine receptor binding studies of homochiral 8-aminopyrido[1,2-a]indoles.
Archiv der Pharmazie 1995;328(7-8):626-8.
1995: Peter Gmeiner; B Bollinger; J Mierau; Georg Höfner
Synthesis, pharmacological investigation and computational studies on a tricyclic ergoline analog with selective dopamine autoreceptor activity.
Archiv der Pharmazie 1995;328(7-8):609-14.
1995: Peter Gmeiner; J Sommer; Georg Höfner
Synthesis and dopamine receptor binding of 3-phenylazepino[5,4,3-c,d]indole derivatives.
Archiv der Pharmazie 1995;328(4):329-32.
1995: Peter Gmeiner; E Hummel; Christian Haubmann; Georg Höfner
Synthesis of (S)-3,4-diaminobutanenitriles as precursors for 3-amino-GABA derivatives.
Archiv der Pharmazie 1995;328(3):265-8.
1994: Peter Gmeiner; J Sommer
[Selective dopamine D-2 autoreceptor agonists with 8-azaindole substructure: synthesis and theoretical studies].
Archiv der Pharmazie 1994;327(7):435-43.
1994: Peter Gmeiner
[Bi- and tricyclic ergoline analogs with dopaminergic actions].
Pharmazie in unserer Zeit 1994;23(3):169-73.
1992: Peter Gmeiner; J Sommer; Georg Höfner; J Mierau
Tricyclic azaergoline analogues: synthesis, structural modifications, and pharmacological studies.
Archiv der Pharmazie 1992;325(10):649-55.
1992: Peter Gmeiner; J Mierau; Georg Höfner
Enantiomerically pure aminoindolizines: bicyclic ergoline analogues with dopamine autoreceptor activity.
Archiv der Pharmazie 1992;325(1):57-60.
1988: Peter Gmeiner; J Sommer
[Azaindol derivatives I: Asymmetric synthesis of new alpha-amino acids].
Archiv der Pharmazie 1988;321(9):505-7.