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JR Gnarra

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Disorders

Genes & Molecular Sequences

Genes, Tumor Suppressor

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N de Paulsen; A Brychzy; MC Fournier; Richard D Klausner; JR Gnarra; Arnim Pause; Stephen Lee
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
McClellan Walther; Robert E Reiter; HR Keiser; Peter L Choyke; David Venzon; Kathleen Hurley; JR Gnarra; J C Reynolds; Gladys Glenn; Berton Zbar; W Marston Linehan
Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma.
S Koochekpour; M Jeffers; P H Wang; C Gong; GA Taylor; L M Roessler; Robert Stearman; James R Vasselli; William Stetler-Stevenson; William G Kaelin; W Marston Linehan; Richard D Klausner; JR Gnarra; George Vande Woude
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.

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All Publications

2001: N de Paulsen; A Brychzy; MC Fournier; Richard D Klausner; JR Gnarra; Arnim Pause; Stephen Lee
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1387-92.
1999: McClellan Walther; Robert E Reiter; HR Keiser; Peter L Choyke; David Venzon; Kathleen Hurley; JR Gnarra; J C Reynolds; Gladys Glenn; Berton Zbar; W Marston Linehan
Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma.
The Journal of urology 1999;162(3 Pt 1):659-64.
1999: S Koochekpour; M Jeffers; P H Wang; C Gong; GA Taylor; L M Roessler; Robert Stearman; James R Vasselli; William Stetler-Stevenson; William G Kaelin; W Marston Linehan; Richard D Klausner; JR Gnarra; George Vande Woude
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.
Molecular and cellular biology 1999;19(9):5902-12.
1997: JR Gnarra; Jerrold M Ward; F D Porter; J R Wagner; D E Devor; Alexander Grinberg; Michael R Emmert-Buck; Heiner Westphal; Richard D Klausner; W Marston Linehan
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9102-7.
1997: McClellan Walther; DE Kleiner; I A Lubensky; R Pozzatti; T Nyguen; JR Gnarra; Kathleen Hurley; David Venzon; W Marston Linehan; William Stetler-Stevenson
Progelatinase A mRNA expression in cell lines derived from tumors in patients with metastatic renal cell carcinoma correlates inversely with survival.
Urology 1997;50(2):295-301.
1997: Alexander O Vortmeyer; JR Gnarra; Michael R Emmert-Buck; D Katz; W Marston Linehan; E H Oldfield; Zhengping Zhuang
von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease.
Human pathology 1997;28(5):540-3.
1996: Irina A Lubensky; JR Gnarra; P Bertheau; McClellan Walther; W Marston Linehan; Zhengping Zhuang
Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients.
The American journal of pathology 1996;149(6):2089-94.
1996: JR Gnarra; S Zhou; Marsha J Merrill; J R Wagner; Anton Krumm; E Papavassiliou; Edward H Oldfield; Richard D Klausner; W Marston Linehan
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10589-94.
1996: Zhengping Zhuang; JR Gnarra; C F Dudley; Berton Zbar; W Marston Linehan; Irina A Lubensky
Detection of von Hippel-Lindau disease gene mutations in paraffin-embedded sporadic renal cell carcinoma specimens.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1996;9(8):838-42.
1996: JR Gnarra; D R Duan; Y Weng; Jeff Humphrey; D Y Chen; S Lee; Arnim Pause; C F Dudley; Farida Latif; Igor Kuzmin; L Schmidt; Fuh-Mei Duh; T Stackhouse; F Chen; T Kishida; Ming-Hui Wei; Michael I Lerman; Berton Zbar; Richard D Klausner; W Marston Linehan
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma.
Biochimica et biophysica acta 1996;1242(3):201-10.
1996: S Lee; D Y Chen; Jeff Humphrey; JR Gnarra; W Marston Linehan; Richard D Klausner
Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):1770-5.
1996: Zhengping Zhuang; Michael R Emmert-Buck; Mark J Roth; JR Gnarra; W Marston Linehan; Lance A Liotta; Irina A Lubensky
von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens.
Human pathology 1996;27(2):152-6.
1995: JR Gnarra; Gregory R Dressler
Expression of Pax-2 in human renal cell carcinoma and growth inhibition by antisense oligonucleotides.
Cancer research 1995;55(18):4092-8.
1995: W P Zhao; JR Gnarra; S Liu; Turid Knutsen; W Marston Linehan; J Whang-Peng
Renal cell carcinoma. Cytogenetic analysis of tumors and cell lines.
Cancer genetics and cytogenetics 1995;82(2):128-39.
1995: D R Duan; Jeff Humphrey; D Y Chen; Y Weng; J Sukegawa; S Lee; JR Gnarra; W Marston Linehan; Richard D Klausner
Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6459-63.
1995: McClellan Walther; P Anglard; JR Gnarra; R Pozzatti; David Venzon; A de la Rosa; N J MacDonald; Patricia S Steeg; W Marston Linehan
Expression of nm23 in cell lines derived from patients with metastatic renal cell carcinoma.
The Journal of urology 1995;154(1):278-82.
1995: Martha A Zeiger; Berton Zbar; HR Keiser; W Marston Linehan; JR Gnarra
Loss of heterozygosity on the short arm of chromosome 3 in sporadic, von Hippel-Lindau disease-associated, and familial pheochromocytoma.
Genes, chromosomes & cancer 1995;13(3):151-6.
1995: McClellan Walther; JR Gnarra; L Elwood; H J Xu; C Florence; P Anglard; S X Hu; C King; E Trahan; Kathleen Hurley
Loss of heterozygosity occurs centromeric to RB without associated abnormalities in the retinoblastoma gene in tumors from patients with metastatic renal cell carcinoma.
The Journal of urology 1995;153(6):2050-4.
1995: S B Jennings; JR Gnarra; McClellan Walther; Berton Zbar; W Marston Linehan
Renal cell carcinoma. Molecular genetics and clinical implications.
Surgical oncology clinics of North America 1995;4(2):219-29.
1995: Zhengping Zhuang; P Bertheau; Michael R Emmert-Buck; Lance A Liotta; JR Gnarra; W Marston Linehan; Irina A Lubensky
A microdissection technique for archival DNA analysis of specific cell populations in lesions < 1 mm in size.
The American journal of pathology 1995;146(3):620-5.
1995: JR Gnarra; Michael I Lerman; Berton Zbar; W Marston Linehan
Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis.
Seminars in oncology 1995;22(1):3-8.
1995: F Chen; T Kishida; M Yao; T Hustad; D Glavac; M Dean; JR Gnarra; M L Orcutt; Fuh-Mei Duh; Gladys Glenn
Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype.
Human mutation 1995;5(1):66-75.
1995: J M Shipley; S Birdsall; J Clark; J Crew; S Gill; M Linehan; JR Gnarra; S Fisher; I W Craig; Colin S Cooper
Mapping the X chromosome breakpoint in two papillary renal cell carcinoma cell lines with a t(X;1)(p11.2;q21.2) and the first report of a female case.
Cytogenetics and cell genetics 1995;71(3):280-4.
1994: Jeffrey A Moscow; L Schmidt; D T Ingram; JR Gnarra; B Johnson; Kenneth H Cowan
Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer.
Carcinogenesis 1994;15(12):2769-73.
1994: James G Herman; F Latif; Y Weng; M I Lerman; B Zbar; S Liu; D Samid; D S Duan; JR Gnarra; W M Linehan
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9700-4.
1994: Martha A Zeiger; JR Gnarra; Berton Zbar; W Marston Linehan; Harvey I Pass
Loss of heterozygosity on the short arm of chromosome 3 in mesothelioma cell lines and solid tumors.
Genes, chromosomes & cancer 1994;11(1):15-20.
1994: Francesco M Marincola; Peter Shamamian; Richard B Alexander; JR Gnarra; Regina L Turetskaya; Sergei A Nedospasov; TB Simonis; Jeffery Taubenberger; J Yannelli; Arnold Mixon
Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1225-37.
1994: Igor Kuzmin; T Stackhouse; Farida Latif; Fuh-Mei Duh; Laura Geil; JR Gnarra; M Yao; M L Orcutt; H Li; K Tory
One-megabase yeast artificial chromosome and 400-kilobase cosmid-phage contigs containing the von Hippel-Lindau tumor suppressor and Ca(2+)-transporting adenosine triphosphatase isoform 2 genes.
Cancer research 1994;54(9):2486-91.
1994: JR Gnarra; K Tory; Y Weng; L Schmidt; Ming-Hui Wei; H Li; Farida Latif; S Liu; F Chen; Fuh-Mei Duh
Mutations of the VHL tumour suppressor gene in renal carcinoma.
Nature genetics 1994;7(1):85-90.
1994: Jeffrey A Moscow; R He; JR Gnarra; Turid Knutsen; Y Weng; W P Zhao; J Whang-Peng; W Marston Linehan; Kenneth H Cowan
Examination of human tumors for rhoA mutations.
Oncogene 1994;9(1):189-94.
1994: J P Long; P Anglard; JR Gnarra; McClellan Walther; Maria J Merino; S Liu; Michael I Lerman; Berton Zbar; W Marston Linehan
The use of molecular genetic analysis in the diagnosis of renal cell carcinoma.
World journal of urology 1994;12(2):69-73.
1993: Robert E Reiter; P Anglard; S Liu; JR Gnarra; W Marston Linehan
Chromosome 17p deletions and p53 mutations in renal cell carcinoma.
Cancer research 1993;53(13):3092-7.
1993: M Makos; Barry D Nelkin; Robert E Reiter; JR Gnarra; J Brooks; William B Isaacs; M Linehan; Stephen B Baylin
Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.
Cancer research 1993;53(12):2719-22.
1993: Farida Latif; K Tory; JR Gnarra; M Yao; Fuh-Mei Duh; M L Orcutt; T Stackhouse; Igor Kuzmin; W Modi; Laura Geil
Identification of the von Hippel-Lindau disease tumor suppressor gene.
Science (New York, N.Y.) 1993;260(5112):1317-20.
1993: JR Gnarra; G M Glenn; Farida Latif; P Anglard; Michael I Lerman; Berton Zbar; W Marston Linehan
Molecular genetic studies of sporadic and familial renal cell carcinoma.
The Urologic clinics of North America 1993;20(2):207-16.
1993: Farida Latif; Fuh-Mei Duh; JR Gnarra; K Tory; Igor Kuzmin; M Yao; T Stackhouse; W Modi; Laura Geil; L Schmidt
von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region.
Cancer research 1993;53(4):861-7.
1992: H Otani; J P Siegel; M Erdos; JR Gnarra; M B Toledano; M Sharon; Howard Mostowski; Mark B Feinberg; J H Pierce; Warren J Leonard
Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2789-93.
1991: M Napolitano; W S Modi; S J Cevario; JR Gnarra; H N Seuanez; Warren J Leonard
The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization.
The Journal of biological chemistry 1991;266(26):17531-6.
1990: M Sharon; JR Gnarra; Warren J Leonard
A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4869-73.
1990: JR Gnarra; H Otani; M G Wang; O W McBride; M Sharon; Warren J Leonard
Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3440-4.
1990: Warren J Leonard; JR Gnarra; M Napolitano; M Sharon
Structure, function, and regulation of the interleukin-2 receptor and identification of a novel immune activation gene.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1239):187-92.
1990: Warren J Leonard; M Sharon; JR Gnarra
Structure and function of interleukin-2 receptors.
Progress in clinical and biological research 1990;352():179-87.
1990: Warren J Leonard; JR Gnarra; M Sharon
The multisubunit interleukin-2 receptor.
Annals of the New York Academy of Sciences 1990;594():200-6.
1989: M Sharon; JR Gnarra; Warren J Leonard
The beta-chain of the IL-2 receptor (p70) is tyrosine-phosphorylated on YT and HUT-102B2 cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(8):2530-3.
1988: M Sharon; JR Gnarra; M Baniyash; Warren J Leonard
Possible association between IL-2 receptors and class I HLA molecules on T cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3512-5.