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Silvia Gobbi

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Federica Belluti; Silvia Gobbi; Angela Rampa; Alessandra Bisi
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 - 2012).
Stefano Rizzo; Andrea Tarozzi; Marco Allarà; Vincenza Andrisano; Manuela Bartolini; Federica Belluti; Alessandra Bisi; Gregory Da Costa; Vincenzo Di Marzo; Silvia Gobbi; Patrizia Hrelia; Alessia Ligresti; Jean-Pierre Monti; Angela Rampa
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.
Angela Rampa; Silvia Gobbi; Federica Belluti; Alessandra Bisi
Hybrid-based multi-target ligands for the treatment of Alzheimer's disease.

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All Publications

2013: Federica Belluti; Silvia Gobbi; Angela Rampa; Alessandra Bisi
Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 - 2012).
Expert opinion on therapeutic patents 2013;23(5):581-96.
2012: Stefano Rizzo; Andrea Tarozzi; Marco Allarà; Vincenza Andrisano; Manuela Bartolini; Federica Belluti; Alessandra Bisi; Gregory Da Costa; Vincenzo Di Marzo; Silvia Gobbi; Patrizia Hrelia; Alessia Ligresti; Jean-Pierre Monti; Angela Rampa
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.
European journal of medicinal chemistry 2012;58():519-32.
2011: Angela Rampa; Silvia Gobbi; Federica Belluti; Alessandra Bisi
Hybrid-based multi-target ligands for the treatment of Alzheimer's disease.
Current topics in medicinal chemistry 2011;11(22):2716-30.
2011: Stefano Rizzo; Vincenza Andrisano; Manuela Bartolini; Federica Belluti; Alessandra Bisi; Silvia Gobbi; Francesca Mancini; Angela Rampa
Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.
European journal of medicinal chemistry 2011;46(9):4336-43.
2010: Silvia Gobbi; Christina Zimmer; Federica Belluti; Angela Rampa; Rolf W Hartmann; Maurizio Recanatini; Alessandra Bisi
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.
Journal of medicinal chemistry 2010;53(14):5347-51.
2010: Stefano Rizzo; Manuela Bartolini; Luisa Ceccarini; Lorna Piazzi; Silvia Gobbi; Andrea Cavalli; Maurizio Recanatini; Vincenza Andrisano; Angela Rampa
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.
Bioorganic & medicinal chemistry 2010;18(5):1749-60.
2009: Sergio Bova; Simona Saponara; Angela Rampa; Silvia Gobbi; Lorenzo Cima; Fabio Fusi; Giampietro Sgaragli; Maurizio Cavalli; Cristobal de los Rios; Jörg Striessnig; Alessandra Bisi
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile.
Journal of medicinal chemistry 2009;52(5):1259-62.
2009: Federica Belluti; Lorna Piazzi; Alessandra Bisi; Silvia Gobbi; Manuela Bartolini; Andrea Cavalli; Piero Valenti; Angela Rampa
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.
European journal of medicinal chemistry 2009;44(3):1341-8.
2008: Alessandra Bisi; Maria Meli; Silvia Gobbi; Angela Rampa; Manlio Tolomeo; Luisa Dusonchet
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives.
Bioorganic & medicinal chemistry 2008;16(13):6474-82.
2008: Silvia Gobbi; Andrea Cavalli; Alessandra Bisi; Maurizio Recanatini
From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer.
Current topics in medicinal chemistry 2008;8(10):869-87.
2008: Mariagnese Barbera; Anna Caputo; Antonella Zampiron; Silvia Gobbi; Angela Rampa; Alessandra Bisi; Maria Carrara
The ability of coumarin-, flavanon- and flavonol-analogues of flavone acetic acid to stimulate human monocytes.
Oncology reports 2008;19(1):187-96.
2007: Lorna Piazzi; Andrea Cavalli; Federica Belluti; Alessandra Bisi; Silvia Gobbi; Stefano Rizzo; Manuela Bartolini; Vincenza Andrisano; Maurizio Recanatini; Angela Rampa
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.
Journal of medicinal chemistry 2007;50(17):4250-4.
2007: Silvia Gobbi; Andrea Cavalli; Matthias Negri; Katarzyna E Schewe; Federica Belluti; Lorna Piazzi; Rolf W Hartmann; Maurizio Recanatini; Alessandra Bisi
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.
Journal of medicinal chemistry 2007;50(15):3420-2.
2007: Lorna Piazzi; Federica Belluti; Alessandra Bisi; Silvia Gobbi; Stefano Rizzo; Manuela Bartolini; Vincenza Andrisano; Maurizio Recanatini; Angela Rampa
Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.
Bioorganic & medicinal chemistry 2007;15(1):575-85.
2006: Silvia Gobbi; Andrea Cavalli; Angela Rampa; Federica Belluti; Lorna Piazzi; Anja Paluszcak; Rolf W Hartmann; Maurizio Recanatini; Alessandra Bisi
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.
Journal of medicinal chemistry 2006;49(15):4777-80.
2006: Silvia Gobbi; Federica Belluti; Alessandra Bisi; Lorna Piazzi; Angela Rampa; Antonella Zampiron; Mariagnese Barbera; Anna Caputo; Maria Carrara
New derivatives of xanthenone-4-acetic acid: synthesis, pharmacological profile and effect on TNF-alpha and NO production by human immune cells.
Bioorganic & medicinal chemistry 2006;14(12):4101-9.
2006: Alessandra Bisi; Silvia Gobbi; Angela Rampa; Federica Belluti; Lorna Piazzi; Piero Valenti; Nora Gyemant; Joseph Molnár
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.
Journal of medicinal chemistry 2006;49(11):3049-51.
2005: Andrea Cavalli; Alessandra Bisi; Carlo Bertucci; Carlo Rosini; Anja Paluszcak; Silvia Gobbi; Egidio Giorgio; Angela Rampa; Federica Belluti; Lorna Piazzi; Piero Valenti; Rolf W Hartmann; Maurizio Recanatini
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach.
Journal of medicinal chemistry 2005;48(23):7282-9.
2005: Federica Belluti; Angela Rampa; Lorna Piazzi; Alessandra Bisi; Silvia Gobbi; Manuela Bartolini; Vincenza Andrisano; Andrea Cavalli; Maurizio Recanatini; Piero Valenti
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.
Journal of medicinal chemistry 2005;48(13):4444-56.
2005: Roberta Budriesi; Alessandra Bisi; Pierfranco Ioan; Angela Rampa; Silvia Gobbi; Federica Belluti; Lorna Piazzi; Piero Valenti; Alberto Chiarini
1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety.
Bioorganic & medicinal chemistry 2005;13(10):3423-30.
2005: Maria Carrara; Antonella Zampiron; Mariagnese Barbera; Anna Caputo; Alessandra Bisi; Silvia Gobbi; Federica Belluti; Lorna Piazzi; Angela Rampa; Piero Valenti
Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity.
Anticancer research 2005;25(2A):1179-85.
2005: Angela Rampa; Alessandra Bisi; Federica Belluti; Silvia Gobbi; Lorna Piazzi; Piero Valenti; Antonella Zampiron; Anna Caputo; Katia Varani; Pier Andrea Borea; Maria Carrara
Homopterocarpanes as bridged triarylethylene analogues: synthesis and antagonistic effects in human MCF-7 breast cancer cells.
Farmaco (Società chimica italiana : 1989) 2005;60(2):135-47.
2004: Federica Federici; Beatrice Vitali; Roberto Gotti; Maria Rosalia Pasca; Silvia Gobbi; Ammon B Peck; Patrizia Brigidi
Characterization and heterologous expression of the oxalyl coenzyme A decarboxylase gene from Bifidobacterium lactis.
Applied and environmental microbiology 2004;70(9):5066-73.
2003: Silvia Gobbi; Angela Rampa; Alessandra Bisi; Federica Belluti; Lorna Piazzi; Piero Valenti; Anna Caputo; Antonella Zampiron; Maria Carrara
Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid.
Journal of medicinal chemistry 2003;46(17):3662-9.
2003: Lorna Piazzi; Angela Rampa; Alessandra Bisi; Silvia Gobbi; Federica Belluti; Andrea Cavalli; Manuela Bartolini; Vincenza Andrisano; Piero Valenti; Maurizio Recanatini
3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.
Journal of medicinal chemistry 2003;46(12):2279-82.
2003: Alessandra Bisi; Angela Rampa; Roberta Budriesi; Silvia Gobbi; Federica Belluti; Pierfranco Ioan; Ermanno Valoti; Alberto Chiarini; Piero Valenti
Cardiovascular hybrid drugs: new benzazepinone derivatives as bradycardic agents endowed with selective beta1-non-competitive antagonism.
Bioorganic & medicinal chemistry 2003;11(7):1353-61.
2002: Silvia Gobbi; Angela Rampa; Alessandra Bisi; Federica Belluti; Piero Valenti; Anna Caputo; Antonella Zampiron; Maria Carrara
Synthesis and antitumor activity of new derivatives of xanthen-9-one-4-acetic acid.
Journal of medicinal chemistry 2002;45(22):4931-9.
2001: Angela Rampa; Lorna Piazzi; Federica Belluti; Silvia Gobbi; Alessandra Bisi; Manuela Bartolini; Vincenza Andrisano; Vanni Cavrini; Andrea Cavalli; Maurizio Recanatini; Piero Valenti
Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.
Journal of medicinal chemistry 2001;44(23):3810-20.
2001: Maurizio Recanatini; Alessandra Bisi; Andrea Cavalli; Federica Belluti; Silvia Gobbi; Angela Rampa; Piero Valenti; Martina Palzer; Anja Palusczak; Rolf W Hartmann
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Journal of medicinal chemistry 2001;44(5):672-80.
2000: Maurizio Recanatini; Andrea Cavalli; Federica Belluti; Lorna Piazzi; Angela Rampa; Alessandra Bisi; Silvia Gobbi; Piero Valenti; Vincenza Andrisano; Manuela Bartolini; Vanni Cavrini
SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.
Journal of medicinal chemistry 2000;43(10):2007-18.
2000: Angela Rampa; Alessandra Bisi; Federica Belluti; Silvia Gobbi; Piero Valenti; Vincenza Andrisano; Vanni Cavrini; Andrea Cavalli; Maurizio Recanatini
Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives.
Bioorganic & medicinal chemistry 2000;8(3):497-506.
2000: Piero Valenti; Alessandra Bisi; Angela Rampa; Federica Belluti; Silvia Gobbi; Antonella Zampiron; Maria Carrara
Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid.
Bioorganic & medicinal chemistry 2000;8(1):239-46.
1998: Piero Valenti; Alessandra Bisi; Angela Rampa; Silvia Gobbi; Federica Belluti; P Da Re; Lorenzo Cima; Maria Carrara
Synthesis of flavone-2'-carboxylic acid analogues as potential antitumor agents.
Anti-cancer drug design 1998;13(8):881-92.