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Stephen Archer

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Gene H Kim; John J Ryan; Stephen L Archer
The role of redox signaling in epigenetics and cardiovascular disease.
Lin Piao; John J Ryan; Vaninder K Sidhu; Peter T Toth; Yong-Hu Fang; Zhigang Hong; Shelby Kutty; Gary D Lopaschuk; Erik Morrow; Kishan S Parikh; Stephen L Archer
FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
Lin Piao; Jennifer Pogoriler; John J Ryan; Tiju Theccanat; Peter T Toth; Burns C Blaxall; Karen M D'Souza; Yong-Hu Fang; Kishan S Parikh; Jonathan Paul; Shahab A Akhter; Stephen L Archer
GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.

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All Publications

2013: Gene H Kim; John J Ryan; Stephen L Archer
The role of redox signaling in epigenetics and cardiovascular disease.
Antioxidants & redox signaling 2013;18(15):1920-36.
2013: Lin Piao; John J Ryan; Vaninder K Sidhu; Peter T Toth; Yong-Hu Fang; Zhigang Hong; Shelby Kutty; Gary D Lopaschuk; Erik Morrow; Kishan S Parikh; Stephen L Archer
FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
Journal of molecular medicine (Berlin, Germany) 2013;91(3):333-46.
2012: Lin Piao; Jennifer Pogoriler; John J Ryan; Tiju Theccanat; Peter T Toth; Burns C Blaxall; Karen M D'Souza; Yong-Hu Fang; Kishan S Parikh; Jonathan Paul; Shahab A Akhter; Stephen L Archer
GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.
Circulation 2012;126(24):2859-69.
2012: Glenn Marsboom; Erik Morrow; Lin Piao; Jennifer Pogoriler; Jalees Rehman; John J Ryan; Thenappan Thenappan; Peter T Toth; E Kenneth Weir; Xichen Wu; Hannah J Zhang; Yimei Chen; Yong-Hu Fang; Zhigang Hong; Stephen L Archer
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Circulation research 2012;110(11):1484-97.
2012: Jalees Rehman; Ravi Salgia; Peter T Toth; Christian Wietholt; Hannah J Zhang; Yanmin Zhang; Zhigang Hong; Aliya N Husain; Glenn Marsboom; Stephen L Archer
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(5):2175-86.
2012: Glenn Marsboom; Erik Morrow; Jonathan Paul; Lin Piao; John J Ryan; Thenappan Thenappan; Peter T Toth; Christian Wietholt; Peter Bache-Wiig; Chin-Tu Chen; Chad R Haney; Stephen L Archer
Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension.
American journal of respiratory and critical care medicine 2012;185(6):670-9.
2012: John J Ryan; Thenappan Thenappan; Thanh Ha; Nancy Luo; Amit R Patel; Stuart Rich; Stephen L Archer
The WHO classification of pulmonary hypertension: A case-based imaging compendium.
Pulmonary circulation 2012;2(1):107-21.
2012: Benjamin H Freed; Mardi Gomberg-Maitland; E Bruce Jamison; Roberto M Lang; Victor Mor-Avi; Stephen L Archer; Sonal Chandra; Stuart Rich; Amit R Patel
Late gadolinium enhancement cardiovascular magnetic resonance predicts clinical worsening in patients with pulmonary hypertension.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2012;14():11.
2011: John J Ryan; Stuart Rich; Stephen L Archer
Pulmonary endarterectomy surgery--a technically demanding cure for WHO Group IV Pulmonary Hypertension: requirements for centres of excellence and availability in Canada.
The Canadian journal of cardiology 2011;27(6):671-4.
2011: Amit R Patel; Kirk T Spencer; Nadera Sweiss; Stephen L Archer; Martin C Burke; Sonal Chandra; Jeanne M DeCara; Edward R Garrity; D Kyle Hogarth; Michael R Klein; Roberto M Lang; John F Beshai
Myocardial damage in patients with sarcoidosis and preserved left ventricular systolic function: an observational study.
European journal of heart failure 2011;13(11):1231-7.
2011: John J Ryan; Jalees Rehman; Stephen L Archer
Paracrine proliferative signaling by senescent cells in world health organization group 3 pulmonary hypertension: age corrupting youth?
Circulation research 2011;109(5):476-9.
2011: Gene H Kim; Glenn Marsboom; John J Ryan; Stephen L Archer
Epigenetic mechanisms of pulmonary hypertension.
Pulmonary circulation 2011;1(3):347-56.
2011: Christina Luong; Juliana Rey-Perra; Arul Vadivel; Greg Gilmour; Yves Sauve; Debby Koonen; Don Walker; Kathryn G Todd; Pierre Gressens; Zamaneh Kassiri; Khurram Nadeem; Beverly Morgan; Farah Eaton; Jason R Dyck; Stephen L Archer; Bernard Thébaud
Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia.
Circulation 2011;123(19):2120-31.
2011: Thenappan Thenappan; Ankush Goel; Glenn Marsboom; Yong-Hu Fang; Peter T Toth; Hannah J Zhang; Hidemi Kajimoto; Zhigang Hong; Jonathan Paul; Christian Wietholt; Jennifer Pogoriler; Lin Piao; Jalees Rehman; Stephen L Archer
A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion.
American journal of respiratory and critical care medicine 2011;183(8):1080-91.
2010: Stuart Rich; Jennifer Pogoriler; Aliya N Husain; Peter T Toth; Mardi Gomberg-Maitland; Stephen L Archer
Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension.
Chest 2010;138(5):1234-9.
2010: Lin Piao; Glenn Marsboom; Stephen L Archer
Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure.
Journal of molecular medicine (Berlin, Germany) 2010;88(10):1011-20.
2010: Stephen L Archer
The mitochondrion as a Swiss army knife: implications for cardiovascular disease.
Journal of molecular medicine (Berlin, Germany) 2010;88(10):963-5.
2010: Dalia Urboniene; Idith Haber; Yong-Hu Fang; Thenappan Thenappan; Stephen L Archer
Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2010;299(3):L401-12.
2010: Daniel I Levy; Egle Cepaitis; Sherry Wanderling; Peter T Toth; Stephen L Archer; Steve A N Goldstein
The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.
The Journal of physiology 2010;588(Pt 14):2657-68.
2010: Stephen L Archer; Glenn Marsboom; Gene H Kim; Hannah J Zhang; Peter P. Toth; Eric C Svensson; Jason R B Dyck; Mardi Gomberg-Maitland; Bernard Thébaud; Aliya N Husain; Nicole Cipriani; Jalees Rehman
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.
Circulation 2010;121(24):2661-71.
2010: Stephen L Archer; E Kenneth Weir; Martin R Wilkins
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies.
Circulation 2010;121(18):2045-66.
2010: T Thenappan; S J Shah; Stuart Rich; L Tian; Stephen L Archer; Mardi Gomberg-Maitland
Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;35(5):1079-87.
2010: Nadera Sweiss; Linda Hushaw; Thenappan Thenappan; Ray Sawaqed; Roberto Machado; Amit R Patel; Mardi Gomberg-Maitland; Aliya N Husain; Stephen L Archer
Diagnosis and management of pulmonary hypertension in systemic sclerosis.
Current rheumatology reports 2010;12(1):8-18.
2010: Sonal Chandra; Sanjiv J Shah; Thenappan Thenappan; Stephen L Archer; Stuart Rich; Mardi Gomberg-Maitland
Carbon monoxide diffusing capacity and mortality in pulmonary arterial hypertension.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010;29(2):181-7.
2010: Elaine Lin; Adrienne Boire; Vagish Hemmige; Aliya N Husain; Matthew Sorrentino; Sandeep Nathan; Shahab A Akhter; Jerome Dickstein; Stephen L Archer
Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report.
Journal of medical case reports 2010;4():246.
2010: Jalees Rehman; Stephen L Archer
A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension.
Advances in experimental medicine and biology 2010;661():171-85.
2010: Lin Piao; Yong-Hu Fang; Virgilio J J Cadete; Christian Wietholt; Dalia Urboniene; Peter T Toth; Glenn Marsboom; Hannah J Zhang; Idith Haber; Jalees Rehman; Gary D Lopaschuk; Stephen L Archer
The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.
Journal of molecular medicine (Berlin, Germany) 2010;88(1):47-60.
2009: Tammy J Bungard; Marcie J Smigorowsky; Lucille D Lalonde; Terry Hogan; Katharine M Doliszny; Ghimay Gebreyesus; Sipi Garg; Stephen L Archer
Cardiac EASE (Ensuring Access and Speedy Evaluation) - the impact of a single-point-of-entry multidisciplinary outpatient cardiology consultation program on wait times in Canada.
The Canadian journal of cardiology 2009;25(12):697-702.
2009: Timothy van Haaften; Roisin Byrne; Sebastien Bonnet; Gael Rochefort; John J Akabutu; Dr Manaf Bouchentouf; Gloria J Rey-Parra; Jacques Galipeau; Alois Haromy; Farah Eaton; Ming Chen; Kyoko Hashimoto; Doris Abley; Gregory S Korbutt; Stephen L Archer; Bernard Thébaud
Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats.
American journal of respiratory and critical care medicine 2009;180(11):1131-42.
2009: Tamar S Polonsky; Linda A Taillon; Harshal Sheth; James K Min; Stephen L Archer; R Parker Ward
The association between erectile dysfunction and peripheral arterial disease as determined by screening ankle-brachial index testing.
Atherosclerosis 2009;207(2):440-4.
2009: Stephen L Archer; Evangelos D Michelakis
Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension.
The New England journal of medicine 2009;361(19):1864-71.
2008: Gloria Juliana Rey-Parra; Stephen L Archer; Richard D Bland; Kurt H Albertine; David P Carlton; Soo-Chul Cho; Beth Kirby; Alois Haromy; Farah Eaton; Xichen Wu; Bernard Thébaud
Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung disease.
American journal of respiratory and critical care medicine 2008;178(4):399-406.
2008: Bernard Thébaud; Xi-Chen Wu; Hidemi Kajimoto; Sandra Bonnet; Kyoko Hashimoto; Evangelos D Michelakis; Stephen L Archer
Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus.
Pediatric research 2008;63(2):176-81.
2007: M Sean McMurtry; Sebastien Bonnet; Evangelos D Michelakis; Sebastien Bonnet; Alois Haromy; Stephen L Archer
Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study.
American journal of physiology. Lung cellular and molecular physiology 2007;293(4):L933-40.
2007: Jayan Nagendran; Stephen L Archer; Daniel Soliman; Vikram Gurtu; Rohit Moudgil; Alois Haromy; Chantal St Aubin; Linda Webster; Ivan M Rebeyka; David B Ross; Peter E Light; Jason R B Dyck; Evangelos D Michelakis
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Circulation 2007;116(3):238-48.
2007: Sebastien Bonnet; Gael Rochefort; Gopinath Sutendra; Stephen L Archer; Alois Haromy; Linda Webster; Kyoko Hashimoto; Sandra N Bonnet; Evangelos D Michelakis
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11418-23.
2007: Sebastien Bonnet; Stephen L Archer
Potassium channel diversity in the pulmonary arteries and pulmonary veins: implications for regulation of the pulmonary vasculature in health and during pulmonary hypertension.
Pharmacology & therapeutics 2007;115(1):56-69.
2007: Hidemi Kajimoto; Kyoko Hashimoto; Sebastien Bonnet; Alois Haromy; Gwyneth Harry; Rohit Moudgil; Toshio Nakanishi; Ivan M Rebeyka; Bernard Thébaud; Evangelos D Michelakis; Stephen L Archer
Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.
Circulation 2007;115(13):1777-88.
2007: M Sean McMurtry; Rohit Moudgil; Kyoko Hashimoto; Sebastien Bonnet; Evangelos D Michelakis; Stephen L Archer
Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension.
American journal of physiology. Lung cellular and molecular physiology 2007;292(4):L872-8.
2007: Stephen L Archer
The making of a physician-scientist--the process has a pattern: lessons from the lives of Nobel laureates in medicine and physiology.
European heart journal 2007;28(4):510-4.
2007: Sebastien Bonnet; Stephen L Archer; Joan Allalunis-Turner; Alois Haromy; Christian Beaulieu; Richard Thompson; Christopher T Lee; Gary D Lopaschuk; Lakshmi Puttagunta; Sandra Bonnet; Gwyneth Harry; Kyoko Hashimoto; Christopher J Porter; Miguel Andrade; Bernard Thebaud; Evangelos D Michelakis
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Cancer cell 2007;11(1):37-51.
2006: Rohit Moudgil; Evangelos D Michelakis; Stephen L Archer
The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension.
Microcirculation (New York, N.Y. : 1994) 2006;13(8):615-32.
2006: E Kenneth Weir; Stephen L Archer
Counterpoint: Hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen species.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;101(3):995-8; discussion 998.
2006: Stephen L Archer; Evangelos D Michelakis
An evidence-based approach to the management of pulmonary arterial hypertension.
Current opinion in cardiology 2006;21(4):385-92.
2006: Sebastien Bonnet; Evangelos D Michelakis; Christopher J Porter; Miguel Andrade; Bernard Thébaud; Sandra Bonnet; Alois Haromy; Gwyneth Harry; Rohit Moudgil; M Sean McMurtry; E Kenneth Weir; Stephen L Archer
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.
Circulation 2006;113(22):2630-41.
2006: Wendy Chrapko; Paul Jurasz; Marek W Radomski; Stephen L Archer; Stephen C Newman; Glen Baker; Nathalie Lara; Jean-Michel Le Mellédo
Alteration of decreased plasma NO metabolites and platelet NO synthase activity by paroxetine in depressed patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(6):1286-93.
2006: Stephen L Archer; Ian Paterson; Gordon A Francis
Images in cardiovascular medicine. Untreated 37-year-old homozygous familial hypercholesterolemic smoker.
Circulation 2006;113(21):e777.
2006: Jayan Nagendran; Ken Stewart; Mike Hoskinson; Stephen L Archer
An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis.
Current opinion in anaesthesiology 2006;19(1):34-43.
2006: Stephen L Archer; Evangelos D Michelakis; Bernard Thébaud; Sebastien Bonnet; Rohit Moudgil; Xi-Chen Wu; E Kenneth Weir
A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system.
Novartis Foundation symposium 2006;272():157-71; discussion 171-5, 214-7.
2005: Bernard Thébaud; Faruqa Ladha; Evangelos D Michelakis; Monika Sawicka; Gavin Thurston; Farah Eaton; Kyoko Hashimoto; Gwyneth Harry; Alois Haromy; Gregory S Korbutt; Stephen L Archer
Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization.
Circulation 2005;112(16):2477-86.
2005: Zhigang Hong; Andrew J Smith; Stephen L Archer; Xi-Chen Wu; Daniel P Nelson; Douglas Peterson; Gerhard Johnson; E Kenneth Weir
Pergolide is an inhibitor of voltage-gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction.
Circulation 2005;112(10):1494-9.
2005: M Sean McMurtry; Stephen L Archer; Dario C Altieri; Sebastien Bonnet; Alois Haromy; Gwyneth Harry; Sebastien Bonnet; Lakshmi Puttagunta; Evangelos D Michelakis
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension.
The Journal of clinical investigation 2005;115(6):1479-91.
2005: Stephen L Archer; Ferrante S Gragasin; Linda Webster; Derek Bochinski; Evangelos D Michelakis
Aetiology and management of male erectile dysfunction and female sexual dysfunction in patients with cardiovascular disease.
Drugs & aging 2005;22(10):823-44.
2005: Rohit Moudgil; Evangelos D Michelakis; Stephen L Archer
Hypoxic pulmonary vasoconstriction.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(1):390-403.
2004: Evangelos D Michelakis; Bernard Thébaud; E Kenneth Weir; Stephen L Archer
Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells.
Journal of molecular and cellular cardiology 2004;37(6):1119-36.
2004: Bernard Thébaud; Evangelos D Michelakis; Xi-Chen Wu; Rohit Moudgil; Michael Kuzyk; Jason R B Dyck; Gwyneth Harry; Kyoko Hashimoto; Alois Haromy; Ivan M Rebeyka; Stephen L Archer
Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus.
Circulation 2004;110(11):1372-9.
2004: Ferrante S Gragasin; Evangelos D Michelakis; Angie Hogan; Rohit Moudgil; Kyoko Hashimoto; Xichen Wu; Sebastien Bonnet; Alois Haromy; Stephen L Archer
The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1382-91.
2004: Stephen L Archer; Xi-Chen Wu; Bernard Thébaud; Ali Nsair; Sebastien Bonnet; Ben Tyrrell; M Sean McMurtry; Kyoko Hashimoto; Gwyneth Harry; Evangelos D Michelakis
Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells.
Circulation research 2004;95(3):308-18.
2004: Wendy Chrapko; Paul Jurasz; Marek W Radomski; Nathalie Lara; Stephen L Archer; Jean-Michel Le Mellédo
Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder.
Biological psychiatry 2004;56(2):129-34.
2004: Linda J Webster; Evangelos D Michelakis; Terry Davis; Stephen L Archer
Use of sildenafil for safe improvement of erectile function and quality of life in men with New York Heart Association classes II and III congestive heart failure: a prospective, placebo-controlled, double-blind crossover trial.
Archives of internal medicine 2004;164(5):514-20.
2004: Stephen L Archer; Xi-Chen Wu; Bernard Thébaud; Rohit Moudgil; Kyoko Hashimoto; Evangelos D Michelakis
O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide.
Biological chemistry 2004;385(3-4):205-16.
2003: Nathalie Lara; Glen B Baker; Stephen L Archer; Jean-Michel Le Mellédo
Increased cholesterol levels during paroxetine administration in healthy men.
The Journal of clinical psychiatry 2003;64(12):1455-9.
2003: Nathalie Lara; Stephen L Archer; Glen B Baker; Jean-Michel Le Mellédo
Paroxetine-induced increase in metabolic end products of nitric oxide.
Journal of clinical psychopharmacology 2003;23(6):641-5.
2003: Evangelos D Michelakis; Wayne Tymchak; Michelle L Noga; Linda Webster; Xi-Chen Wu; Dale Lien; Shao-Hua Wang; Dennis L Modry; Stephen L Archer
Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension.
Circulation 2003;108(17):2066-9.
2003: Nathalie Lara; Wendy Chrapko; Stephen L Archer; François Bellavance; Irvin Mayers; Jean-Michel Le Mellédo
Pulmonary and systemic nitric oxide measurements during CCK-5-induced panic attacks.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(10):1840-5.
2003: Nathalie Lara; Stephen L Archer; Glen B Baker; Jean-Michel Le Mellédo
Paroxetine-induced increase in metabolic end products of nitric oxide.
Journal of clinical psychopharmacology 2003;23(4):408-12.
2003: Zlatko I Pozeg; Evangelos D Michelakis; M Sean McMurtry; Bernard Thébaud; Xi-Chen Wu; Jason R B Dyck; Kyoko Hashimoto; Shaohua Wang; Rohit Moudgil; Gwyneth Harry; Richard Sultanian; Arvind Koshal; Stephen L Archer
In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats.
Circulation 2003;107(15):2037-44.
2003: Stephen L Archer; Ferrante S Gragasin; Xichen Wu; Shaohua Wang; Sean McMurtry; Daniel H Kim; Michael Platonov; Arvind Koshal; Kyoko Hashimoto; William B Campbell; J R Falck; Evangelos D Michelakis
Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels.
Circulation 2003;107(5):769-76.
2003: Evangelos D Michelakis; M Sean McMurtry; Brian Sonnenberg; Stephen L Archer
The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.
Advances in experimental medicine and biology 2003;543():293-322.
2002: Vladimír Hampl; Jana Bíbová; Zbynek Stranák; Xichen Wu; Evangelos D Michelakis; Kyoko Hashimoto; Stephen L Archer
Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition.
American journal of physiology. Heart and circulatory physiology 2002;283(6):H2440-9.
2002: Evangelos D Michelakis; Ivan M Rebeyka; XiChen Wu; Ali Nsair; Bernard Thébaud; Kyoko Hashimoto; Jason R B Dyck; Alois Haromy; Gwyneth Harry; Amy Barr; Stephen L Archer
O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor.
Circulation research 2002;91(6):478-86.
2002: Bernard Thébaud; Evangelos D Michelakis; Xi-Chen Wu; Gwyneth Harry; Kyoko Hashimoto; Stephen L Archer
Sildenafil reverses O2 constriction of the rabbit ductus arteriosus by inhibiting type 5 phosphodiesterase and activating BK(Ca) channels.
Pediatric research 2002;52(1):19-24.
2002: Evangelos D Michelakis; Vladimír Hampl; Ali Nsair; XiCheng Wu; Gwyneth Harry; Alois Haromy; Rachita Gurtu; Stephen L Archer
Diversity in mitochondrial function explains differences in vascular oxygen sensing.
Circulation research 2002;90(12):1307-15.
2002: Evangelos D Michelakis; M Sean McMurtry; Xi-Chen Wu; Jason R B Dyck; Rohit Moudgil; Teresa A Hopkins; Gary D Lopaschuk; Lakshmi Puttagunta; Ross Waite; Stephen L Archer
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Circulation 2002;105(2):244-50.
2002: Stephen L Archer
Potassium channels and erectile dysfunction.
Vascular pharmacology 2002;38(1):61-71.
2001: Stephen L Archer; B London; Vladimír Hampl; XiCheng Wu; Ali Nsair; Lakshmi Puttagunta; Kyoko Hashimoto; Ross Waite; Evangelos D Michelakis
Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(10):1801-3.
2001: Helen L Reeve; Evangelos D Michelakis; Daniel P Nelson; E Kenneth Weir; Stephen L Archer
Alterations in a redox oxygen sensing mechanism in chronic hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;90(6):2249-56.
2001: Evangelos D Michelakis; E Kenneth Weir; XiCheng Wu; Ali Nsair; Ross Waite; Kyoko Hashimoto; Lakshmi Puttagunta; H G Knaus; Stephen L Archer
Potassium channels regulate tone in rat pulmonary veins.
American journal of physiology. Lung cellular and molecular physiology 2001;280(6):L1138-47.
2001: Douglas A Peterson; Helen L Reeve; D Nelson; Stephen L Archer; E Kenneth Weir
Triple-bonded unsaturated fatty acids are redox active compounds.
Lipids 2001;36(4):431-3.
2001: Evangelos D Michelakis; Jason R B Dyck; M Sean McMurtry; Shaohua Wang; Xi-Chen Wu; Rohit Moudgil; Kyoko Hashimoto; Lakshmi Puttagunta; Stephen L Archer
Gene transfer and metabolic modulators as new therapies for pulmonary hypertension. Increasing expression and activity of potassium channels in rat and human models.
Advances in experimental medicine and biology 2001;502():401-18.
2000: Jay H Traverse; Y L Wang; Ruisheng Du; D Nelson; P Lindstrom; Stephen L Archer; G Gong; Robert J Bache
Coronary nitric oxide production in response to exercise and endothelium-dependent agonists.
Circulation 2000;101(21):2526-31.
2000: Stephen L Archer; E Kenneth Weir; Helen L Reeve; Evangelos D Michelakis
Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation.
Advances in experimental medicine and biology 2000;475():219-40.
1999: Evangelos D Michelakis; E Kenneth Weir; Daniel P Nelson; Helen L Reeve; S Tolarova; Stephen L Archer
Dexfenfluramine elevates systemic blood pressure by inhibiting potassium currents in vascular smooth muscle cells.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1143-9.
1999: D N Cornfield; E B Martin; Vladimír Hampl; Stephen L Archer
Aerosol delivery of diethylenetriamine/nitric oxide, a nitric oxide adduct, causes selective pulmonary vasodilation in perinatal lambs.
The Journal of laboratory and clinical medicine 1999;134(4):419-25.
1999: Helen L Reeve; Stephen L Archer; M Soper; E Kenneth Weir
Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2+, independent of membrane potential.
The American journal of physiology 1999;277(3 Pt 1):L662-6.
1999: Bernard Thébaud; D Tibboel; C Rambaud; Jean-Christophe Mercier; Jacques R Bourbon; Anh Tuan Dinh-Xuan; Stephen L Archer
Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats.
The American journal of physiology 1999;277(2 Pt 1):L423-9.
1999: Stephen L Archer; Helen L Reeve; Evangelos D Michelakis; Lakshmi Puttagunta; Ross Waite; Daniel P Nelson; M C Dinauer; E Kenneth Weir
O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7944-9.
1999: Helen L Reeve; Daniel P Nelson; Stephen L Archer; E Kenneth Weir
Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology.
The American journal of physiology 1999;276(2 Pt 1):L213-9.
1999: Douglas A Peterson; D C Peterson; Helen L Reeve; Stephen L Archer; E Kenneth Weir
GTP (gammaS) and GDP (betaS) as electron donors: new wine in old bottles.
Life sciences 1999;65(11):1135-40.
1998: Helen L Reeve; E Kenneth Weir; Stephen L Archer; David N Cornfield
A maturational shift in pulmonary K+ channels, from Ca2+ sensitive to voltage dependent.
The American journal of physiology 1998;275(6 Pt 1):L1019-25.
1998: Stephen L Archer; K Djaballah; M Humbert; K E Weir; M Fartoukh; Josette Dall'Ava-Santucci; Jean-Christophe Mercier; G Simonneau; Anh Tuan Dinh-Xuan
Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension.
American journal of respiratory and critical care medicine 1998;158(4):1061-7.
1998: E Kenneth Weir; Helen L Reeve; G Johnson; Evangelos D Michelakis; Daniel P Nelson; Stephen L Archer
A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension.
Chest 1998;114(3 Suppl):200S-204S.
1998: E Kenneth Weir; Helen L Reeve; Douglas A Peterson; Evangelos D Michelakis; Daniel P Nelson; Stephen L Archer
Pulmonary vasoconstriction, oxygen sensing, and the role of ion channels: Thomas A. Neff lecture.
Chest 1998;114(1 Suppl):17S-22S.
1998: Stephen L Archer; Evelyne Souil; Anh Tuan Dinh-Xuan; B Schremmer; Jean-Christophe Mercier; A El Yaagoubi; L Nguyen-Huu; Helen L Reeve; Vladimír Hampl
Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes.
The Journal of clinical investigation 1998;101(11):2319-30.
1998: Evangelos D Michelakis; Stephen L Archer
The measurement of NO in biological systems using chemiluminescence.
Methods in molecular biology (Clifton, N.J.) 1998;100():111-27.
1997: Helen L Reeve; Stephen L Archer; E Kenneth Weir
Ion channels in the pulmonary vasculature.
Pulmonary pharmacology & therapeutics 1997;10(5-6):243-52.
1997: Evangelos D Michelakis; Helen L Reeve; J M Huang; S Tolarova; Daniel P Nelson; E Kenneth Weir; Stephen L Archer
Potassium channel diversity in vascular smooth muscle cells.
Canadian journal of physiology and pharmacology 1997;75(7):889-97.
1997: E Kenneth Weir; Helen L Reeve; David N Cornfield; M Tristani-Firouzi; Douglas A Peterson; Stephen L Archer
Diversity of response in vascular smooth muscle cells to changes in oxygen tension.
Kidney international 1997;51(2):462-6.
1996: M Tristani-Firouzi; E B Martin; S Tolarova; E Kenneth Weir; Stephen L Archer; David N Cornfield
Ventilation-induced pulmonary vasodilation at birth is modulated by potassium channel activity.
The American journal of physiology 1996;271(6 Pt 2):H2353-9.
1996: M Tristani-Firouzi; Helen L Reeve; S Tolarova; E Kenneth Weir; Stephen L Archer
Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel.
The Journal of clinical investigation 1996;98(9):1959-65.
1996: E Kenneth Weir; Helen L Reeve; J M Huang; Evangelos D Michelakis; Daniel P Nelson; Vladimír Hampl; Stephen L Archer
Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction.
Circulation 1996;94(9):2216-20.
1996: W C Dillon; Vladimír Hampl; P J Shultz; Jeffrey B Rubins; Stephen L Archer
Origins of breath nitric oxide in humans.
Chest 1996;110(4):930-8.
1996: E J Sidney; Vladimír Hampl; Daniel P Nelson; Stephen L Archer; M L Foegh; S S Cathapermal; E Kenneth Weir
The somatostatin analog angiopeptin does not reduce chronic hypoxic pulmonary hypertension in rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1996;213(1):43-9.
1996: Vladimír Hampl; M Tristani-Firouzi; Daniel P Nelson; Stephen L Archer
Chronic infusion of nitric oxide in experimental pulmonary hypertension: pulmonary pressure-flow analysis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(7):1475-81.
1996: Stephen L Archer
Diversity of phenotype and function of vascular smooth muscle cells.
The Journal of laboratory and clinical medicine 1996;127(6):524-9.
1996: Stephen L Archer; J M Huang; Helen L Reeve; Vladimír Hampl; S Tolarová; Evangelos D Michelakis; E Kenneth Weir
Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia.
Circulation research 1996;78(3):431-42.
1996: Vladimír Hampl; M Tristani-Firouzi; T C Hutsell; Stephen L Archer
Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension.
Cardiovascular research 1996;31(1):55-62.
1995: Helen L Reeve; E Kenneth Weir; Daniel P Nelson; D A Peterson; Stephen L Archer
Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue.
Experimental physiology 1995;80(5):825-34.
1995: Stephen L Archer; Vladimír Hampl; Daniel P Nelson; E Sidney; D A Peterson; E Kenneth Weir
Dithionite increases radical formation and decreases vasoconstriction in the lung. Evidence that dithionite does not mimic alveolar hypoxia.
Circulation research 1995;77(1):174-81.
1995: Stephen L Archer; K A Freude; P J Shultz
Effect of graded hypoxia on the induction and function of inducible nitric oxide synthase in rat mesangial cells.
Circulation research 1995;77(1):21-8.
1995: Vladimír Hampl; David N Cornfield; N J Cowan; Stephen L Archer
Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(4):515-22.
1995: Evangelos D Michelakis; Stephen L Archer; E Kenneth Weir
Acute hypoxic pulmonary vasoconstriction: a model of oxygen sensing.
Physiological research / Academia Scientiarum Bohemoslovaca 1995;44(6):361-7.
1995: Vladimír Hampl; J M Huang; E Kenneth Weir; Stephen L Archer
Activation of the cGMP-dependent protein kinase mimics the stimulatory effect of nitric oxide and cGMP on calcium-gated potassium channels.
Physiological research / Academia Scientiarum Bohemoslovaca 1995;44(1):39-44.
1994: P J Shultz; Stephen L Archer; M E Rosenberg
Inducible nitric oxide synthase mRNA and activity in glomerular mesangial cells.
Kidney international 1994;46(3):683-9.
1994: Stephen L Archer; J M Huang; Vladimír Hampl; Daniel P Nelson; P J Shultz; E Kenneth Weir
Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7583-7.
1994: E Kenneth Weir; C N Wyatt; Helen L Reeve; J Huang; Stephen L Archer; Chris Peers
Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(6):2611-5.
1994: T C Isaacson; Vladimír Hampl; E Kenneth Weir; Daniel P Nelson; Stephen L Archer
Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(2):933-40.
1993: Vladimír Hampl; Stephen L Archer; R Bach; Daniel P Nelson; E Kenneth Weir
Chronic hypoxic pulmonary hypertension. Is thrombin involved?
The American review of respiratory disease 1993;148(4 Pt 1):1043-8.
1993: Vladimír Hampl; Stephen L Archer; Daniel P Nelson; E Kenneth Weir
Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(4):1748-57.
1993: T D Henry; Stephen L Archer; D Nelson; E Kenneth Weir; A H From
Postischemic oxygen radical production varies with duration of ischemia.
The American journal of physiology 1993;264(5 Pt 2):H1478-84.
1993: D A Peterson; D C Peterson; Stephen L Archer; E Kenneth Weir
Superoxide dismutase: an antireductant enzyme?
Biochemical Society transactions 1993;21(2):88S.
1992: Stephen L Archer; Vladimír Hampl
NG-monomethyl-L-arginine causes nitric oxide synthesis in isolated arterial rings: trouble in paradise.
Biochemical and biophysical research communications 1992;188(2):590-6.
1991: Stephen L Archer; N J Cowan
Measurement of endothelial cytosolic calcium concentration and nitric oxide production reveals discrete mechanisms of endothelium-dependent pulmonary vasodilatation.
Circulation research 1991;68(6):1569-81.
1990: T D Henry; Stephen L Archer; D Nelson; E Kenneth Weir; A H From
Enhanced chemiluminescence as a measure of oxygen-derived free radical generation during ischemia and reperfusion.
Circulation research 1990;67(6):1453-61.
1990: Stephen L Archer; K Rist; Daniel P Nelson; E G DeMaster; N Cowan; E Kenneth Weir
Comparison of the hemodynamic effects of nitric oxide and endothelium-dependent vasodilators in intact lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(2):735-47.
1989: Stephen L Archer; Daniel P Nelson; E Kenneth Weir
Detection of activated O2 species in vitro and in rat lungs by chemiluminescence.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(5):1912-21.
1989: Stephen L Archer; Daniel P Nelson; E Kenneth Weir
Simultaneous measurement of O2 radicals and pulmonary vascular reactivity in rat lung.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(5):1903-11.
1989: Stephen L Archer; D Peterson; Daniel P Nelson; E G DeMaster; B Kelly; J W Eaton; E Kenneth Weir
Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(1):102-11.