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Paul Godowski

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TOP 3
Paul J Godowski
A smooth operator for LPS responses.
Alex Abbas; D Baldwin; Y Ma; W Ouyang; Austin Gurney; F Martin; Sherman Fong; Menno van Lookeren Campagne; Paul J Godowski; P M Williams; A C Chan; H F Clark
Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data.
Ofer Levy; Kol A Zarember; Rene M Roy; Colette Cywes; Paul J Godowski; Michael R Wessels
Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

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All Publications

2005: Paul J Godowski
A smooth operator for LPS responses.
Nature immunology 2005;6(6):544-6.
2005: Alex Abbas; D Baldwin; Y Ma; W Ouyang; Austin Gurney; F Martin; Sherman Fong; Menno van Lookeren Campagne; Paul J Godowski; P M Williams; A C Chan; H F Clark
Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data.
Genes and immunity 2005;6(4):319-31.
2004: Ofer Levy; Kol A Zarember; Rene M Roy; Colette Cywes; Paul J Godowski; Michael R Wessels
Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4627-34.
2004: Mitsuhiro Iwahashi; Masahiro Yamamura; Tetsushi Aita; Akira Okamoto; Akiko Ueno; Norio Ogawa; Sachiko Akashi; Kensuke Miyake; Paul J Godowski; Hirofumi Makino
Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis.
Arthritis and rheumatism 2004;50(5):1457-67.
2004: Kerstin N Schmidt; Beatrice Leung; Mandy Kwong; Kol A Zarember; Sanjeev Satyal; Tony A Navas; Fay Wang; Paul J Godowski
APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):138-43.
2003: Cheryl J Hertz; Qi Wu; Edith Martin Porter; Yan J Zhang; Karl-Heinz Weismüller; Paul J Godowski; Tomas Ganz; Scott H Randell; Robert L Modlin
Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6820-6.
2003: Ofer Levy; Rochelle M Jean-Jacques; Colette Cywes; Richard B Sisson; Kol A Zarember; Paul J Godowski; Jennifer L Christianson; Hilde-Kari Guttormsen; Michael C Carroll; Anne Nicholson-Weller; Michael R Wessels
Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release.
Infection and immunity 2003;71(11):6344-53.
2003: Stephan R Krutzik; Maria Teresa Ochoa; Peter Allan Sieling; Satoshi Uematsu; Yolanda W Ng; Annaliza J Legaspi; Philip T Liu; Stewart T Cole; Paul J Godowski; Yumi Maeda; Euzenir N Sarno; Michael V Norgard; Patrick J Brennan; Shizuo Akira; Thomas H Rea; Robert L Modlin
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.
Nature medicine 2003;9(5):525-32.
2003: Maria Teresa Ochoa; Annaliza J Legaspi; Zena Hatziris; Paul J Godowski; Robert L Modlin; Peter Allan Sieling
Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue.
Immunology 2003;108(1):10-5.
2003: Peter Allan Sieling; Woosin Chung; Baochau T Duong; Paul J Godowski; Robert L Modlin
Toll-like receptor 2 ligands as adjuvants for human Th1 responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):194-200.
2002: Jenny Kim; Maria Teresa Ochoa; Stephan R Krutzik; Osamu Takeuchi; Satoshi Uematsu; Annaliza J Legaspi; Hans D Brightbill; Diana Holland; William J Cunliffe; Shizuo Akira; Peter Allan Sieling; Paul J Godowski; Robert L Modlin
Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1535-41.
2002: Kol A Zarember; Paul J Godowski
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):554-61.
2001: Andrew T Gewirtz; T A Navas; Sean Lyons; Paul J Godowski; James L Madara
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1882-5.
2001: Catherine Werts; Tapping Richard; John C Mathison; Tsung-Hsien Chuang; Vladimir V Kravchenko; Isabelle Saint-Girons; D A Haake; Paul J Godowski; F Hayashi; Adrian Ozinsky; David M Underhill; Carsten J Kirschning; H Wagner; Alan Aderem; Peter S Tobias; Richard J Ulevitch
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.
Nature immunology 2001;2(4):346-52.
2001: S Thoma-Uszynski; Steffen Stenger; O Takeuchi; Maria Teresa Ochoa; Matthias Engele; Peter Allan Sieling; PF Barnes; M Rollinghoff; P L Bolcskei; Manfred Wagner; Shizuo Akira; Michael V Norgard; John Belisle; Paul J Godowski; Barry R Bloom; Robert L Modlin
Induction of direct antimicrobial activity through mammalian toll-like receptors.
Science (New York, N.Y.) 2001;291(5508):1544-7.
2001: Cheryl J Hertz; Sylvia M Kiertscher; Paul J Godowski; DA Bouis; Michael V Norgard; Michael D Roth; Robert L Modlin
Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2444-50.
2000: L Arbibe; Jean-Paul Mira; N Teusch; Lawrence E Kline; Mausumee Guha; Nigel Mackman; Paul J Godowski; Richard J Ulevitch; Ulla G Knaus
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
Nature immunology 2000;1(6):533-40.
2000: Tapping Richard; S Akashi; K Miyake; Paul J Godowski; Peter S Tobias
Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5780-7.
2000: S Thoma-Uszynski; Sylvia M Kiertscher; Maria Teresa Ochoa; DA Bouis; Michael V Norgard; K Miyake; Paul J Godowski; Michael D Roth; Robert L Modlin
Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3804-10.
2000: AO Aliprantis; RB Yang; David S Weiss; Paul J Godowski; Arturo Zychlinsky
The apoptotic signaling pathway activated by Toll-like receptor-2.
The EMBO journal 2000;19(13):3325-36.
1999: AO Aliprantis; RB Yang; MR Mark; S Suggett; B Devaux; J D Radolf; G R Klimpel; Paul J Godowski; Arturo Zychlinsky
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2.
Science (New York, N.Y.) 1999;285(5428):736-9.
1999: Hans D Brightbill; D H Libraty; Stephan R Krutzik; RB Yang; John Belisle; Joshua R Bleharski; M Maitland; Michael V Norgard; Scott Plevy; S T Smale; Patrick J Brennan; Barry R Bloom; Paul J Godowski; Robert L Modlin
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Science (New York, N.Y.) 1999;285(5428):732-6.
1999: RB Yang; MR Mark; Austin Gurney; Paul J Godowski
Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):639-43.
1999: Robert L Modlin; Hans D Brightbill; Paul J Godowski
The toll of innate immunity on microbial pathogens.
The New England journal of medicine 1999;340(23):1834-5.
1999: Austin Gurney; Scot A Marsters; R M Huang; Robert M Pitti; D T Mark; DT Baldwin; A M Gray; A D Dowd; A D Brush; A D Heldens; A D Schow; Audrey D Goddard; William I Wood; K P Baker; Paul J Godowski; Avi Ashkenazi
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.
Current biology : CB 1999;9(4):215-8.
1998: Robert M Pitti; Scot A Marsters; David A Lawrence; M Roy; Frank Kischkel; Patrick Dowd; A Huang; C J Donahue; S W Sherwood; DT Baldwin; Paul J Godowski; William I Wood; Austin Gurney; Kenneth J Hillan; R L Cohen; Audrey D Goddard; D Botstein; Avi Ashkenazi
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer.
Nature 1998;396(6712):699-703.
1998: RB Yang; MR Mark; A Gray; A Huang; Ming-Hong Xie; M Zhang; A Goddard; William I Wood; Austin Gurney; Paul J Godowski
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling.
Nature 1998;395(6699):284-8.
1998: D Zhang; Gretchen D Frantz; Paul J Godowski
New branches on the neuregulin family tree.
Molecular psychiatry 1998;3(2):112-5.
1997: Scot A Marsters; JP Sheridan; Robert M Pitti; A Huang; M Skubatch; D Baldwin; J Yuan; Austin Gurney; Audrey D Goddard; Paul J Godowski; Avi Ashkenazi
A novel receptor for Apo2L/TRAIL contains a truncated death domain.
Current biology : CB 1997;7(12):1003-6.
1997: D Zhang; M X Sliwkowski; M Mark; Gretchen D Frantz; Robert W Akita; Y Sun; Kenneth J Hillan; Craig W Crowley; J Brush; Paul J Godowski
Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9562-7.
1997: JP Sheridan; Scot A Marsters; Robert M Pitti; Austin Gurney; M Skubatch; D Baldwin; L Ramakrishnan; C L Gray; K Baker; William I Wood; Audrey D Goddard; Paul J Godowski; Avi Ashkenazi
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.
Science (New York, N.Y.) 1997;277(5327):818-21.
1997: J Chen; K Carey; Paul J Godowski
Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.
Oncogene 1997;14(17):2033-9.
1996: R H Schwall; L Y Chang; Paul J Godowski; D W Kahn; Kenneth J Hillan; K D Bauer; Thomas F Zioncheck
Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.
The Journal of cell biology 1996;133(3):709-18.
1996: R Li; J Chen; G Hammonds; H Phillips; Mark P Armanini; Patrick M Wood; R Bunge; Paul J Godowski; Mark X Sliwkowski; J P Mather
Identification of Gas6 as a growth factor for human Schwann cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(6):2012-9.
1996: F Hefti; Mark P Armanini; K D Beck; IW Caras; K S Chen; Paul J Godowski; L J Goodman; R G Hammonds; M R Mark; P Moran; M C Nishimura; Heidi S Phillips; A Shih; J Valverde; JW Winslow
Development of neurotrophic factor therapy for Alzheimer's disease.
Ciba Foundation symposium 1996;196():54-63; discussion 63-9.
1995: Paul J Godowski; M R Mark; J Chen; M D Sadick; H Raab; R G Hammonds
Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3.
Cell 1995;82(3):355-8.
1994: Giovanni Gaudino; Antonia Follenzi; L Naldini; C Collesi; M Santoro; Kathleen A Gallo; Paul J Godowski; paolo comoglio
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.
The EMBO journal 1994;13(15):3524-32.
1994: N A Lokker; L G Presta; Paul J Godowski
Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor.
Protein engineering 1994;7(7):895-903.
1994: Kathleen A Gallo; M R Mark; D T Scadden; Zack Zhengyu Wang; Q Gu; Paul J Godowski
Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.
The Journal of biological chemistry 1994;269(21):15092-100.
1994: M R Mark; D T Scadden; Zack Zhengyu Wang; Q Gu; A Goddard; Paul J Godowski
rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.
The Journal of biological chemistry 1994;269(14):10720-8.
1994: Thomas F Zioncheck; L Richardson; G G DeGuzman; N B Modi; S E Hansen; Paul J Godowski
The pharmacokinetics, tissue localization, and metabolic processing of recombinant human hepatocyte growth factor after intravenous administration in rats.
Endocrinology 1994;134(4):1879-87.
1993: N A Lokker; Paul J Godowski
Generation and characterization of a competitive antagonist of human hepatocyte growth factor, HGF/NK1.
The Journal of biological chemistry 1993;268(23):17145-50.
1992: M R Mark; N A Lokker; Thomas F Zioncheck; E A Luis; Paul J Godowski
Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding.
The Journal of biological chemistry 1992;267(36):26166-71.
1992: F Roos; T G Terrell; Paul J Godowski; S M Chamow; R H Schwall
Reduction of alpha-naphthylisothiocyanate-induced hepatotoxicity by recombinant human hepatocyte growth factor.
Endocrinology 1992;131(6):2540-4.
1992: K S Christopherson; M R Mark; V Bajaj; Paul J Godowski
Ecdysteroid-dependent regulation of genes in mammalian cells by a Drosophila ecdysone receptor and chimeric transactivators.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6314-8.
1992: N A Lokker; M R Mark; E A Luis; G L Bennett; K A Robbins; J B Baker; Paul J Godowski
Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.
The EMBO journal 1992;11(7):2503-10.
1990: S A Spencer; D W Leung; Paul J Godowski; R G Hammonds; M J Waters; William I Wood
Growth hormone receptor and binding protein.
Recent progress in hormone research 1990;46():165-81; discussion 181-3.
1989: Paul J Godowski; D W Leung; Lillian R Meacham; J P Galgani; R Hellmiss; R Keret; Peter Rotwein; John Parks; Zvi Laron; William I Wood
Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):8083-7.