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Werner Goebel

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Thilo M Fuchs; Wolfgang Eisenreich; Jürgen Heesemann; Werner Goebel
Metabolic adaptation of human pathogenic and related nonpathogenic bacteria to extra- and intracellular habitats.
Nadine Gillmaier; Andreas Götz; Anette Schulz; Wolfgang Eisenreich; Werner Goebel
Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes.
Torsten Hain; Ben Izar; Uwe Kärst; Carsten Tobias Kuenne; Rainer Merkl; Walid Mohamed; Mobarak Abu Mraheil; Sebastian Oehm; Alfred Pühler; Christophe Rusniok; Silke Schaffrath; Christiane Steinweg; Sonja Vorwerk; Eugen Domann; Patricia Garrido; Rohit Ghai; Philippe Glaser; Werner Goebel; Alexander Goesmann; André Billion; Carmen Buchrieser; Trinad Chakraborty
Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes.

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All Publications

2012: Thilo M Fuchs; Wolfgang Eisenreich; Jürgen Heesemann; Werner Goebel
Metabolic adaptation of human pathogenic and related nonpathogenic bacteria to extra- and intracellular habitats.
FEMS microbiology reviews 2012;36(2):435-62.
2012: Nadine Gillmaier; Andreas Götz; Anette Schulz; Wolfgang Eisenreich; Werner Goebel
Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes.
PloS one 2012;7(12):e52378.
2012: Torsten Hain; Ben Izar; Uwe Kärst; Carsten Tobias Kuenne; Rainer Merkl; Walid Mohamed; Mobarak Abu Mraheil; Sebastian Oehm; Alfred Pühler; Christophe Rusniok; Silke Schaffrath; Christiane Steinweg; Sonja Vorwerk; Eugen Domann; Patricia Garrido; Rohit Ghai; Philippe Glaser; Werner Goebel; Alexander Goesmann; André Billion; Carmen Buchrieser; Trinad Chakraborty
Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes.
BMC genomics 2012;13():144.
2011: Carmen Buchrieser; Trinad Chakraborty; Pascale Cossart; P Garrido; Werner Goebel; Torsten Hain; Uwe Kärst; Jürgen Kreft; Robert Lampidis; Christophe Rusniok; Mariela Scortti; Jose A Vazquez-Boland; Philippe Glaser
Complete genome sequence of the animal pathogen Listeria ivanovii, which provides insights into host specificities and evolution of the genus Listeria.
Journal of bacteriology 2011;193(23):6787-8.
2011: Martin Heisig; Christian Hotz; Ulf R Rapp; Christoph Schoen; Jochen Stritzker; Birgit Bergmann; Joachim Fensterle; Alexa Frentzen; Katharina Galmbacher; Ivaylo Gentschev; Werner Goebel
Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines.
BMC microbiology 2011;11():163.
2010: Albrecht Ludwig; Guido Völkerink; Christine von Rhein; Susanne Bauer; Elke Maier; Birgit Bergmann; Werner Goebel; Roland Benz
Mutations affecting export and activity of cytolysin A from Escherichia coli.
Journal of bacteriology 2010;192(15):4001-11.
2010: Wolfgang Eisenreich; Thomas Dandekar; Jürgen Heesemann; Werner Goebel
Carbon metabolism of intracellular bacterial pathogens and possible links to virulence.
Nature reviews. Microbiology 2010;8(6):401-12.
2010: Jennifer Schär; Regina Stoll; Kristina Schauer; Daniela I M Loeffler; Eva Eylert; Biju Joseph; Wolfgang Eisenreich; Thilo M Fuchs; Werner Goebel
Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes.
Journal of bacteriology 2010;192(7):1774-84.
2010: Andreas Götz; Werner Goebel
Glucose and glucose 6-phosphate as carbon sources in extra- and intracellular growth of enteroinvasive Escherichia coli and Salmonella enterica.
Microbiology (Reading, England) 2010;156(Pt 4):1176-87.
2010: Regina Stoll; Werner Goebel
The major PEP-phosphotransferase systems (PTSs) for glucose, mannose and cellobiose of Listeria monocytogenes, and their significance for extra- and intracellular growth.
Microbiology (Reading, England) 2010;156(Pt 4):1069-83.
2010: Christiane Steinweg; Carsten Tobias Kuenne; André Billion; Mobarak A Mraheil; Eugen Domann; Rohit Ghai; Sukhadeo B Barbuddhe; Uwe Kärst; Alexander Goesmann; Alfred Pühler; Bernd Weisshaar; Jürgen Wehland; Robert Lampidis; Jürgen Kreft; Werner Goebel; Trinad Chakraborty; Torsten Hain
Complete genome sequence of Listeria seeligeri, a nonpathogenic member of the genus Listeria.
Journal of bacteriology 2010;192(5):1473-4.
2010: Kristina Schauer; Gernot Geginat; Chunguang Liang; Werner Goebel; Thomas Dandekar; Thilo M Fuchs
Deciphering the intracellular metabolism of Listeria monocytogenes by mutant screening and modelling.
BMC genomics 2010;11():573.
2010: Andreas Götz; Eva Eylert; Wolfgang Eisenreich; Werner Goebel
Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (Caco-2) cells.
PloS one 2010;5(5):e10586.
2010: Katharina Galmbacher; Martin Heisig; Christian Hotz; Joerg Wischhusen; Antoine Galmiche; Birgit Bergmann; Ivaylo Gentschev; Werner Goebel; Ulf R Rapp; Joachim Fensterle
Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression.
PloS one 2010;5(3):e9572.
2009: Tina Rajabian; Balramakrishna Gavicherla; Martin Heisig; Stefanie Müller-Altrock; Werner Goebel; Scott D Gray-Owen; Keith Ireton
The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria.
Nature cell biology 2009;11(10):1212-8.
2009: Christian Hotz; Joachim Fensterle; Werner Goebel; Susanne R Meyer; Gabriel Kirchgraber; Martin Heisig; Andreas Fürer; Guido Dietrich; Ulf R Rapp; Ivaylo Gentschev
Improvement of the live vaccine strain Salmonella enterica serovar Typhi Ty21a for antigen delivery via the hemolysin secretion system of Escherichia coli.
International journal of medical microbiology : IJMM 2009;299(2):109-19.
2009: Christine von Rhein; Susanne Bauer; Enrique Javier López Sanjurjo; Roland Benz; Werner Goebel; Albrecht Ludwig
ClyA cytolysin from Salmonella: distribution within the genus, regulation of expression by SlyA, and pore-forming characteristics.
International journal of medical microbiology : IJMM 2009;299(1):21-35.
2008: Regina Stoll; Sonja Mertins; Biju Joseph; Stefanie Müller-Altrock; Werner Goebel
Modulation of PrfA activity in Listeria monocytogenes upon growth in different culture media.
Microbiology (Reading, England) 2008;154(Pt 12):3856-76.
2008: Eva Eylert; Jennifer Schär; Sonja Mertins; Regina Stoll; Adelbert Bacher; Werner Goebel; Wolfgang Eisenreich
Carbon metabolism of Listeria monocytogenes growing inside macrophages.
Molecular microbiology 2008;69(4):1008-17.
2008: Biju Joseph; Sonja Mertins; Regina Stoll; Jennifer Schär; Kanasinakatte Rudrappa Umesha; Qin Luo; Stefanie Müller-Altrock; Werner Goebel
Glycerol metabolism and PrfA activity in Listeria monocytogenes.
Journal of bacteriology 2008;190(15):5412-30.
2008: Stephanie Weibel; Jochen Stritzker; Matthias Eck; Werner Goebel; Aladar A Szalay
Colonization of experimental murine breast tumours by Escherichia coli K-12 significantly alters the tumour microenvironment.
Cellular microbiology 2008;10(6):1235-48.
2008: Joachim Fensterle; Birgit Bergmann; C L R P Yone; C Hotz; Susanne R Meyer; Simone Spreng; Werner Goebel; Ulf R Rapp; Ivaylo Gentschev
Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B.
Cancer gene therapy 2008;15(2):85-93.
2008: Jochen Stritzker; Sabine Pilgrim; Aladar A Szalay; Werner Goebel
Prodrug converting enzyme gene delivery by L. monocytogenes.
BMC cancer 2008;8():94.
2008: Christoph Schoen; Daniela I M Loeffler; Alexa Frentzen; Sabine Pilgrim; Werner Goebel; Jochen Stritzker
Listeria monocytogenes as novel carrier system for the development of live vaccines.
International journal of medical microbiology : IJMM 2008;298(1-2):45-58.
2007: Torsten Hain; Som Subhra Chatterjee; Rohit Ghai; Carsten Tobias Kuenne; André Billion; Christiane Steinweg; Eugen Domann; Uwe Kärst; Lothar Jänsch; Jürgen Wehland; Wolfgang Eisenreich; Adelbert Bacher; Biju Joseph; Jennifer Schär; Jürgen Kreft; Jochen Klumpp; Martin J Loessner; Julia Dorscht; Klaus Neuhaus; Thilo M Fuchs; Siegfried Scherer; Michel Doumith; Christine Jacquet; Paul Martin; Pascale Cossart; Christophe Rusniock; Philippe Glaser; Carmen Buchrieser; Werner Goebel; Trinad Chakraborty
Pathogenomics of Listeria spp.
International journal of medical microbiology : IJMM 2007;297(7-8):541-57.
2007: Biju Joseph; Werner Goebel
Life of Listeria monocytogenes in the host cells' cytosol.
Microbes and infection / Institut Pasteur 2007;9(10):1188-95.
2007: Jochen Stritzker; Stephanie Weibel; Philip J Hill; Tobias A Oelschlaeger; Werner Goebel; Aladar A Szalay
Tumor-specific colonization, tissue distribution, and gene induction by probiotic Escherichia coli Nissle 1917 in live mice.
International journal of medical microbiology : IJMM 2007;297(3):151-62.
2007: Ivaylo Gentschev; Simone Spreng; Heike Sieber; Jose Ures; Fabian Mollet; Andre Collioud; Jon Pearman; Monika Griot-Wenk; Joachim Fensterle; Ulf R Rapp; Werner Goebel; Simon A Rothen; Guido Dietrich
Vivotif--a 'magic shield' for protection against typhoid fever and delivery of heterologous antigens.
Chemotherapy 2007;53(3):177-80.
2007: Sonja Mertins; Biju Joseph; Monika Goetz; Regina Ecke; Gerald Seidel; Mareen Sprehe; Wolfgang Hillen; Werner Goebel; Stefanie Müller-Altrock
Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes.
Journal of bacteriology 2007;189(2):473-90.
2006: Norman Mauder; Regina Ecke; Sonja Mertins; Daniela I M Loeffler; Gerald Seidel; Mareen Sprehe; Wolfgang Hillen; Werner Goebel; Stefanie Müller-Altrock
Species-specific differences in the activity of PrfA, the key regulator of listerial virulence genes.
Journal of bacteriology 2006;188(22):7941-56.
2006: Torsten Hain; Christiane Steinweg; Carsten Tobias Kuenne; André Billion; Rohit Ghai; Som Subhra Chatterjee; Eugen Domann; Uwe Kärst; Alexander Goesmann; Thomas Bekel; Daniela Bartels; Olaf Kaiser; Folker Meyer; Alfred Pühler; Bernd Weisshaar; Jürgen Wehland; Chunguang Liang; Thomas Dandekar; Robert Lampidis; Jürgen Kreft; Werner Goebel; Trinad Chakraborty
Whole-genome sequence of Listeria welshimeri reveals common steps in genome reduction with Listeria innocua as compared to Listeria monocytogenes.
Journal of bacteriology 2006;188(21):7405-15.
2006: Daniela I M Loeffler; Christoph Schoen; Werner Goebel; Sabine Pilgrim
Comparison of different live vaccine strategies in vivo for delivery of protein antigen or antigen-encoding DNA and mRNA by virulence-attenuated Listeria monocytogenes.
Infection and immunity 2006;74(7):3946-57.
2006: A K Marr; Biju Joseph; Sonja Mertins; Regina Ecke; Stefanie Müller-Altrock; Werner Goebel
Overexpression of PrfA leads to growth inhibition of Listeria monocytogenes in glucose-containing culture media by interfering with glucose uptake.
Journal of bacteriology 2006;188(11):3887-901.
2006: Wolfgang Eisenreich; Jörg Slaghuis; Ralf Laupitz; Johanna Bussemer; Jochen Stritzker; Christine Schwarz; Roland Schwarz; Thomas Dandekar; Werner Goebel; Adelbert Bacher
13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2040-5.
2006: Biju Joseph; Karin Przybilla; Claudia Stühler; Kristina Schauer; Jörg Slaghuis; Thilo M Fuchs; Werner Goebel
Identification of Listeria monocytogenes genes contributing to intracellular replication by expression profiling and mutant screening.
Journal of bacteriology 2006;188(2):556-68.
2005: Tatjana Williams; Biju Joseph; Dagmar Beier; Werner Goebel; Michael Kuhn
Response regulator DegU of Listeria monocytogenes regulates the expression of flagella-specific genes.
FEMS microbiology letters 2005;252(2):287-98.
2005: Christoph Schoen; Annette Kolb-Mäurer; Gernot Geginat; Daniela Löffler; Birgit Bergmann; Jochen Stritzker; Aladar A Szalay; Sabine Pilgrim; Werner Goebel
Bacterial delivery of functional messenger RNA to mammalian cells.
Cellular microbiology 2005;7(5):709-24.
2005: Jochen Stritzker; Christoph Schoen; Werner Goebel
Enhanced synthesis of internalin A in aro mutants of Listeria monocytogenes indicates posttranscriptional control of the inlAB mRNA.
Journal of bacteriology 2005;187(8):2836-45.
2005: Ivaylo Gentschev; Joachim Fensterle; Andreas Schmidt; Tamara Potapenko; Jakob Troppmair; Werner Goebel; Ulf R Rapp
Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice.
BMC cancer 2005;5():15.
2005: Qin Luo; Michael Herler; Stefanie Müller-Altrock; Werner Goebel
Supportive and inhibitory elements of a putative PrfA-dependent promoter in Listeria monocytogenes.
Molecular microbiology 2005;55(4):986-97.
2005: Michael W Schmid; Eva Y W Ng; Robert Lampidis; Melanie Emmerth; Marion Walcher; Jürgen Kreft; Werner Goebel; Michael Wagner; Karl-Heinz Schleifer
Evolutionary history of the genus Listeria and its virulence genes.
Systematic and applied microbiology 2005;28(1):1-18.
2005: Marcus Rauch; Qin Luo; Stefanie Müller-Altrock; Werner Goebel
SigB-dependent in vitro transcription of prfA and some newly identified genes of Listeria monocytogenes whose expression is affected by PrfA in vivo.
Journal of bacteriology 2005;187(2):800-4.
2004: Jochen Stritzker; Werner Goebel
Listeria monocytogenes infection-dependent transfer of exogenously added DNA to fibroblast COS-1 cells.
Molecular genetics and genomics : MGG 2004;272(5):497-503.
2004: Ivaylo Gentschev; Guido Dietrich; Simone Spreng; Beatrice Neuhaus; Elke Maier; Roland Benz; Werner Goebel; Joachim Fensterle; Ulf R Rapp
Use of the alpha-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain.
International journal of medical microbiology : IJMM 2004;294(6):363-71.
2004: Christoph Schoen; Jochen Stritzker; Werner Goebel; Sabine Pilgrim
Bacteria as DNA vaccine carriers for genetic immunization.
International journal of medical microbiology : IJMM 2004;294(5):319-35.
2004: Jochen Stritzker; Jozef Janda; Christoph Schoen; Marcus Taupp; Sabine Pilgrim; Ivaylo Gentschev; Peter Schreier; Gernot Geginat; Werner Goebel
Growth, virulence, and immunogenicity of Listeria monocytogenes aro mutants.
Infection and immunity 2004;72(10):5622-9.
2004: Albrecht Ludwig; Christine von Rhein; Susanne Bauer; Christian Hüttinger; Werner Goebel
Molecular analysis of cytolysin A (ClyA) in pathogenic Escherichia coli strains.
Journal of bacteriology 2004;186(16):5311-20.
2004: Yolanda Vega; Markus Rauch; Mark J Banfield; Svetlana Ermolaeva; Mariela Scortti; Werner Goebel; José A Vázquez-Boland
New Listeria monocytogenes prfA* mutants, transcriptional properties of PrfA* proteins and structure-function of the virulence regulator PrfA.
Molecular microbiology 2004;52(6):1553-65.
2004: Qin Luo; Marcus Rauch; Alexandra K Marr; Stefanie Müller-Altrock; Werner Goebel
In vitro transcription of the Listeria monocytogenes virulence genes inlC and mpl reveals overlapping PrfA-dependent and -independent promoters that are differentially activated by GTP.
Molecular microbiology 2004;52(1):39-52.
2004: Annette Kolb-Mäurer; Florian Weissinger; Oliver Kurzai; Mathias Mäurer; Martin Wilhelm; Werner Goebel
Bacterial infection of human hematopoietic stem cells induces monocytic differentiation.
FEMS immunology and medical microbiology 2004;40(2):147-53.
2004: Jörg Slaghuis; Monika Goetz; Fredi Engelbrecht; Werner Goebel
Inefficient replication of Listeria innocua in the cytosol of mammalian cells.
The Journal of infectious diseases 2004;189(3):393-401.
2003: Sabine Pilgrim; Jochen Stritzker; Christoph Schoen; Annette Kolb-Mäurer; Gernot Geginat; M J Loessner; Ivaylo Gentschev; Werner Goebel
Bactofection of mammalian cells by Listeria monocytogenes: improvement and mechanism of DNA delivery.
Gene therapy 2003;10(24):2036-45.
2003: Annette Kolb-Mäurer; Werner Goebel
Susceptibility of hematopoietic stem cells to pathogens: role in virus/bacteria tropism and pathogenesis.
FEMS microbiology letters 2003;226(2):203-7.
2003: Annette Kolb-Mäurer; Oliver Kurzai; Werner Goebel; Matthias Frosch
The role of human dendritic cells in meningococcal and listerial meningitis.
International journal of medical microbiology : IJMM 2003;293(4):241-9.
2003: Sabine Pilgrim; Annette Kolb-Mäurer; Ivaylo Gentschev; Werner Goebel; Michael Kuhn
Deletion of the gene encoding p60 in Listeria monocytogenes leads to abnormal cell division and loss of actin-based motility.
Infection and immunity 2003;71(6):3473-84.
2003: Roy Gross; Jörg Hacker; Werner Goebel
The Leopoldina international symposium on parasitism, commensalism and symbiosis--common themes, different outcome.
Molecular microbiology 2003;47(6):1749-58.
2003: Simone Spreng; Guido Dietrich; Werner Goebel; Ivaylo Gentschev
Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing protective listerial epitopes within a surface-exposed loop of the TolC-protein.
Vaccine 2003;21(7-8):746-52.
2003: Tobias Hertzig; Martin Weber; Lars Greiffenberg; Britta Schulte Holthausen; Werner Goebel; Kwang S Kim; Michael Kuhn
Antibodies present in normal human serum inhibit invasion of human brain microvascular endothelial cells by Listeria monocytogenes.
Infection and immunity 2003;71(1):95-100.
2002: Annette Kolb-Mäurer; Martin Wilhelm; Florian Weissinger; Eva-B Bröcker; Werner Goebel
Interaction of human hematopoietic stem cells with bacterial pathogens.
Blood 2002;100(10):3703-9.
2002: Andrea Spory; Armin Bosserhoff; Christine von Rhein; Werner Goebel; Albrecht Ludwig
Differential regulation of multiple proteins of Escherichia coli and Salmonella enterica serovar Typhimurium by the transcriptional regulator SlyA.
Journal of bacteriology 2002;184(13):3549-59.
2002: Ulrich Dobrindt; Levente Emödy; Ivaylo Gentschev; Werner Goebel; Jörg Hacker
Efficient expression of the alpha-haemolysin determinant in the uropathogenic Escherichia coli strain 536 requires the leuX-encoded tRNA(5)(Leu).
Molecular genetics and genomics : MGG 2002;267(3):370-9.
2002: Birgit Bergmann; Diana Raffelsbauer; Michael Kuhn; Monika Goetz; Silke Hom; Werner Goebel
InlA- but not InlB-mediated internalization of Listeria monocytogenes by non-phagocytic mammalian cells needs the support of other internalins.
Molecular microbiology 2002;43(3):557-70.
2002: Ivaylo Gentschev; Guido Dietrich; Simone Spreng; Sabine Pilgrim; Jochen Stritzker; Annette Kolb-Mäurer; Werner Goebel
Delivery of protein antigens and DNA by attenuated intracellular bacteria.
International journal of medical microbiology : IJMM 2002;291(6-7):577-82.
2002: Isabel Chico-Calero; Mónica Suárez; Bruno González-Zorn; Mariela Scortti; Jörg Slaghuis; Werner Goebel; José A Vázquez-Boland
Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):431-6.
2002: Jürgen Kreft; José A Vázquez-Boland; S Altrock; Gustavo Domínguez-Bernal; Werner Goebel
Pathogenicity islands and other virulence elements in Listeria.
Current topics in microbiology and immunology 2002;264(2):109-25.
2002: Ivaylo Gentschev; Guido Dietrich; Werner Goebel
The E. coli alpha-hemolysin secretion system and its use in vaccine development.
Trends in microbiology 2002;10(1):39-45.
2001: Monika Goetz; A Bubert; G Wang; Isabel Chico-Calero; J A Vazquez-Boland; M Beck; Jörg Slaghuis; Aladar A Szalay; Werner Goebel
Microinjection and growth of bacteria in the cytosol of mammalian host cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12221-6.
2001: M Lalic-Mülthaler; J Bohne; Werner Goebel
In vitro transcription of PrfA-dependent and -independent genes of Listeria monocytogenes.
Molecular microbiology 2001;42(1):111-20.
2001: M Herler; A Bubert; Monika Goetz; Y Vega; J A Vazquez-Boland; Werner Goebel
Positive selection of mutations leading to loss or reduction of transcriptional activity of PrfA, the central regulator of Listeria monocytogenes virulence.
Journal of bacteriology 2001;183(19):5562-70.
2001: José A Vázquez-Boland; M Kuhn; P Berche; Trinad Chakraborty; Gustavo Domínguez-Bernal; Werner Goebel; Bruno González-Zorn; Jürgen Wehland; Jürgen Kreft
Listeria pathogenesis and molecular virulence determinants.
Clinical microbiology reviews 2001;14(3):584-640.
2001: José A Vázquez-Boland; Gustavo Domínguez-Bernal; Bruno González-Zorn; Jürgen Kreft; Werner Goebel
Pathogenicity islands and virulence evolution in Listeria.
Microbes and infection / Institut Pasteur 2001;3(7):571-84.
2001: Werner Goebel; Roy Gross
Intracellular survival strategies of mutualistic and parasitic prokaryotes.
Trends in microbiology 2001;9(6):267-73.
2001: Annette Kolb-Mäurer; Sabine Pilgrim; Eckhart Kämpgen; Alexander D McLellan; Eva-B Bröcker; Werner Goebel; Ivaylo Gentschev
Antibodies against listerial protein 60 act as an opsonin for phagocytosis of Listeria monocytogenes by human dendritic cells.
Infection and immunity 2001;69(5):3100-9.
2001: Ivaylo Gentschev; Guido Dietrich; Simone Spreng; Annette Kolb-Mäurer; Volker Brinkmann; Leander Grode; Juergen H Hess; Stefan H E Kaufmann; Werner Goebel
Recombinant attenuated bacteria for the delivery of subunit vaccines.
Vaccine 2001;19(17-19):2621-8.
2001: Guido Dietrich; Annette Kolb-Mäurer; Simone Spreng; M Schartl; Werner Goebel; Ivaylo Gentschev
Gram-positive and Gram-negative bacteria as carrier systems for DNA vaccines.
Vaccine 2001;19(17-19):2506-12.
2001: Guido Dietrich; Juergen H Hess; Ivaylo Gentschev; Bettina Knapp; Stefan H E Kaufmann; Werner Goebel
From evil to good: a cytolysin in vaccine development.
Trends in microbiology 2001;9(1):23-8.
2000: Juergen H Hess; Leander Grode; Ivaylo Gentschev; Joachim Fensterle; Guido Dietrich; Werner Goebel; Stefan H E Kaufmann
Secretion of different listeriolysin cognates by recombinant attenuated Salmonella typhimurium: superior efficacy of haemolytic over non-haemolytic constructs after oral vaccination.
Microbes and infection / Institut Pasteur 2000;2(15):1799-806.
2000: Simone Spreng; Ivaylo Gentschev; Werner Goebel; Gerald Weidinger; Volker ter Meulen; Stefan Niewiesk
Salmonella vaccines secreting measles virus epitopes induce protective immune responses against measles virus encephalitis.
Microbes and infection / Institut Pasteur 2000;2(14):1687-92.
2000: Guido Dietrich; Simone Spreng; Ivaylo Gentschev; Werner Goebel
Bacterial systems for the delivery of eukaryotic antigen expression vectors.
Antisense & nucleic acid drug development 2000;10(5):391-9.
2000: Ivaylo Gentschev; Guido Dietrich; Simone Spreng; Annette Kolb-Mäurer; Justin Daniels; Juergen H Hess; S H Kaufmann; Werner Goebel
Delivery of protein antigens and DNA by virulence-attenuated strains of Salmonella typhimurium and Listeria monocytogenes.
Journal of biotechnology 2000;83(1-2):19-26.
2000: Justin Daniels; I B Autenrieth; Werner Goebel
Interaction of Listeria monocytogenes with the intestinal epithelium.
FEMS microbiology letters 2000;190(2):323-8.
2000: Annette Kolb-Mäurer; Ivaylo Gentschev; HW Fries; F Fiedler; Eva-B Bröcker; Eckhart Kämpgen; Werner Goebel
Listeria monocytogenes-infected human dendritic cells: uptake and host cell response.
Infection and immunity 2000;68(6):3680-8.
2000: Lars Greiffenberg; Werner Goebel; Kwang S Kim; Justin Daniels; Michael Kuhn
Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: an electron microscopic study.
Infection and immunity 2000;68(6):3275-9.
2000: Simone Spreng; Ivaylo Gentschev; Werner Goebel; Hans-Joachim Mollenkopf; Matthias Eck; H K Müller-Hermelink; Bernd Schmausser
Identification of immunogenic antigens of Helicobacter pylori via the Escherichia coli hemolysin secretion system(1).
FEMS microbiology letters 2000;186(2):251-6.
2000: T Pfeuffer; Werner Goebel; J Laubinger; M Bachmann; Michael Kuhn
LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system, co-localizes with intracellular Listeria monocytogenes.
Cellular microbiology 2000;2(2):101-14.
2000: R Böckmann; C Dickneite; Werner Goebel; J Bohne
PrfA mediates specific binding of RNA polymerase of Listeria monocytogenes to PrfA-dependent virulence gene promoters resulting in a transcriptionally active complex.
Molecular microbiology 2000;36(2):487-97.
2000: Simone Spreng; Guido Dietrich; Stefan Niewiesk; Volker ter Meulen; Ivaylo Gentschev; Werner Goebel
Novel bacterial systems for the delivery of recombinant protein or DNA.
FEMS immunology and medical microbiology 2000;27(4):299-304.
2000: Juergen H Hess; Leander Grode; J Hellwig; P Conradt; Ivaylo Gentschev; Werner Goebel; CH Ladel; Stefan H E Kaufmann
Protection against murine tuberculosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the 30-kDa antigen of Mycobacterium bovis BCG.
FEMS immunology and medical microbiology 2000;27(4):283-9.
2000: Werner Goebel; Michael Kuhn
Bacterial replication in the host cell cytosol.
Current opinion in microbiology 2000;3(1):49-53.
2000: B Kimmel; Anja Bosserhoff; R Frank; Roy Gross; Werner Goebel; Dagmar Beier
Identification of immunodominant antigens from Helicobacter pylori and evaluation of their reactivities with sera from patients with different gastroduodenal pathologies.
Infection and immunity 2000;68(2):915-20.
2000: G Nagy; Ulrich Dobrindt; Gabriele Blum-Oehler; L Emódy; Werner Goebel; Jörg Hacker
Analysis of the hemolysin determinants of the uropathogenic Escherichia coli strain 536.
Advances in experimental medicine and biology 2000;485():57-61.
2000: G Dietrich; Werner Goebel
DNA vaccine delivery by attenuated intracellular bacteria.
Sub-cellular biochemistry 2000;33():541-57.
2000: Michael Kuhn; Werner Goebel
Internalization of Listeria monocytogenes by nonprofessional and professional phagocytes.
Sub-cellular biochemistry 2000;33():411-36.
2000: Rolf Köhler; A Bubert; Werner Goebel; Michael Steinert; Jörg Hacker; B Bubert
Expression and use of the green fluorescent protein as a reporter system in Legionella pneumophila.
Molecular & general genetics : MGG 2000;262(6):1060-9.
1999: Michael Kuhn; T Pfeuffer; Lars Greiffenberg; Werner Goebel
Host cell signal transduction during Listeria monocytogenes infection.
Archives of biochemistry and biophysics 1999;372(1):166-72.
1999: A Bubert; Ingeborg Hein; Marcus Rauch; A Lehner; B Yoon; Werner Goebel; Michael Wagner
Detection and differentiation of Listeria spp. by a single reaction based on multiplex PCR.
Applied and environmental microbiology 1999;65(10):4688-92.
1999: N Hauf; Werner Goebel; F Fiedler; Michael Kuhn
Listeria monocytogenes infection of Caco-2 human epithelial cells induces activation of transcription factor NF-kappa B/Rel-like DNA binding activities.
FEMS microbiology letters 1999;178(1):117-22.
1999: M Emmerth; Werner Goebel; S I Miller; CJ Hueck
Genomic subtraction identifies Salmonella typhimurium prophages, F-related plasmid sequences, and a novel fimbrial operon, stf, which are absent in Salmonella typhi.
Journal of bacteriology 1999;181(18):5652-61.
1999: Simone Spreng; Guido Dietrich; Werner Goebel; Ivaylo Gentschev
The Escherichia coli haemolysin secretion apparatus: a potential universal antigen delivery system in gram-negative bacterial vaccine carriers.
Molecular microbiology 1999;31(5):1596-8.
1999: A Bubert; Z Sokolovic; S K Chun; L Papatheodorou; Andreas Simm; Werner Goebel
Differential expression of Listeria monocytogenes virulence genes in mammalian host cells.
Molecular & general genetics : MGG 1999;261(2):323-36.
1999: Albrecht Ludwig; S Bauer; Roland Benz; Birgit Bergmann; Werner Goebel
Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12.
Molecular microbiology 1999;31(2):557-67.
1998: Yolanda Vega; C Dickneite; Maria-Teresa Ripio; R Böckmann; Bruno González-Zorn; Susana Novella; Gustavo Domínguez-Bernal; Werner Goebel; José A Vázquez-Boland
Functional similarities between the Listeria monocytogenes virulence regulator PrfA and cyclic AMP receptor protein: the PrfA* (Gly145Ser) mutation increases binding affinity for target DNA.
Journal of bacteriology 1998;180(24):6655-60.
1998: Diana Raffelsbauer; A Bubert; Fredi Engelbrecht; J Scheinpflug; Andreas Simm; Juergen H Hess; Stefan H E Kaufmann; Werner Goebel
The gene cluster inlC2DE of Listeria monocytogenes contains additional new internalin genes and is important for virulence in mice.
Molecular & general genetics : MGG 1998;260(2-3):144-58.
1998: Lars Greiffenberg; Werner Goebel; Kwang S Kim; I Weiglein; A Bubert; Fredi Engelbrecht; Monique F Stins; Michael Kuhn
Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: InlB-dependent invasion, long-term intracellular growth, and spread from macrophages to endothelial cells.
Infection and immunity 1998;66(11):5260-7.
1998: Fredi Engelbrecht; Gustavo Domínguez-Bernal; Juergen H Hess; C Dickneite; Lars Greiffenberg; Robert Lampidis; Diana Raffelsbauer; Justin Daniels; Jürgen Kreft; Stefan H E Kaufmann; José A Vázquez-Boland; Werner Goebel
A novel PrfA-regulated chromosomal locus, which is specific for Listeria ivanovii, encodes two small, secreted internalins and contributes to virulence in mice.
Molecular microbiology 1998;30(2):405-17.
1998: Ivaylo Gentschev; I Glaser; Werner Goebel; Declan J McKeever; Anthony J Musoke; Volker T Heussler
Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: secretion of the product enhances specific antibody responses in cattle.
Infection and immunity 1998;66(5):2060-4.
1998: Stephanie Schuller; S Kügler; Werner Goebel
Suppression of major histocompatibility complex class I and class II gene expression in Listeria monocytogenes-infected murine macrophages.
FEMS immunology and medical microbiology 1998;20(4):289-99.
1998: C Dickneite; R Böckmann; Andrea Spory; Werner Goebel; Z Sokolovic
Differential interaction of the transcription factor PrfA and the PrfA-activating factor (Paf) of Listeria monocytogenes with target sequences.
Molecular microbiology 1998;27(5):915-28.
1998: Michael Wagner; Michael Schmid; Stefan Juretschko; K H Trebesius; Andreas Bubert; Werner Goebel; Karl-Heinz Schleifer
In situ detection of a virulence factor mRNA and 16S rRNA in Listeria monocytogenes.
FEMS microbiology letters 1998;160(1):159-68.
1998: Guido Dietrich; A Bubert; Ivaylo Gentschev; Z Sokolovic; Andreas Simm; Andre Catic; Stefan H E Kaufmann; Juergen H Hess; Aladar A Szalay; Werner Goebel
Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes.
Nature biotechnology 1998;16(2):181-5.
1998: Fredi Engelbrecht; C Dickneite; Robert Lampidis; M Götz; U DasGupta; Werner Goebel
Sequence comparison of the chromosomal regions encompassing the internalin C genes (inlC) of Listeria monocytogenes and L. ivanovii.
Molecular & general genetics : MGG 1998;257(2):186-97.
1998: Michael Kuhn; Werner Goebel
Host cell signalling during Listeria monocytogenes infection.
Trends in microbiology 1998;6(1):11-5.
1997: Lars Greiffenberg; Z Sokolovic; Hans-Joachim Schnittler; Andrea Spory; R Böckmann; Werner Goebel; Michael Kuhn
Listeria monocytogenes-infected human umbilical vein endothelial cells: internalin-independent invasion, intracellular growth, movement, and host cell responses.
FEMS microbiology letters 1997;157(1):163-70.
1997: S Kügler; Stephanie Schuller; Werner Goebel
Involvement of MAP-kinases and -phosphatases in uptake and intracellular replication of Listeria monocytogenes in J774 macrophage cells.
FEMS microbiology letters 1997;157(1):131-6.
1997: S Schlör; A Schmidt; Elke Maier; Roland Benz; Werner Goebel; Ivaylo Gentschev
In vivo and in vitro studies on interactions between the components of the hemolysin (HlyA) secretion machinery of Escherichia coli.
Molecular & general genetics : MGG 1997;256(3):306-19.
1997: A Bubert; H Kestler; M Götz; R Böckmann; Werner Goebel
The Listeria monocytogenes iap gene as an indicator gene for the study of PrfA-dependent regulation.
Molecular & general genetics : MGG 1997;256(1):54-62.
1997: N Hauf; Werner Goebel; F Fiedler; Z Sokolovic; Michael Kuhn
Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9394-9.
1997: Michael Kuhn; Werner Goebel
Responses by murine macrophages infected with Listeria monocytogenes crucial for the development of immunity to this pathogen.
Immunological reviews 1997;158():57-67.
1997: Juergen H Hess; G Dietrich; Ivaylo Gentschev; D Miko; Werner Goebel; Stefan H E Kaufmann
Protection against murine listeriosis by an attenuated recombinant Salmonella typhimurium vaccine strain that secretes the naturally somatic antigen superoxide dismutase.
Infection and immunity 1997;65(4):1286-92.
1997: I Weiglein; Werner Goebel; Jakob Troppmair; Ulf R Rapp; A Demuth; Michael Kuhn
Listeria monocytogenes infection of HeLa cells results in listeriolysin O-mediated transient activation of the Raf-MEK-MAP kinase pathway.
FEMS microbiology letters 1997;148(2):189-95.
1997: Werner Goebel; Jürgen Kreft
Cytolysins and the intracellular life of bacteria.
Trends in microbiology 1997;5(3):86-8.
1997: Juergen H Hess; D Miko; Ivaylo Gentschev; G Dietrich; Werner Goebel; Hans-Joachim Mollenkopf; CH Ladel; Stefan H E Kaufmann
Modulation of antigen display by attenuated Salmonella typhimurium strains and its impact on protective immunity against listeriosis.
Behring Institute Mitteilungen 1997;(98):160-71.
1997: Ivaylo Gentschev; Guido Dietrich; Hans-Joachim Mollenkopf; Z Sokolovic; Juergen H Hess; Stefan H E Kaufmann; Werner Goebel
The Escherichia coli hemolysin secretion apparatus--a versatile antigen delivery system in attenuated Salmonella.
Behring Institute Mitteilungen 1997;(98):103-13.
1997: I Karunasagar; Robert Lampidis; Werner Goebel; Jürgen Kreft
Complementation of Listeria seeligeri with the plcA-prfA genes from L. monocytogenes activates transcription of seeligerolysin and leads to bacterial escape from the phagosome of infected mammalian cells.
FEMS microbiology letters 1997;146(2):303-10.
1997: A Bubert; J Riebe; N Schnitzler; A Schönberg; Werner Goebel; P Schubert
Isolation of catalase-negative Listeria monocytogenes strains from listeriosis patients and their rapid identification by anti-p60 antibodies and/or PCR.
Journal of clinical microbiology 1997;35(1):179-83.
1996: Justin Daniels; Ingo B Autenrieth; Albrecht Ludwig; Werner Goebel
The gene slyA of Salmonella typhimurium is required for destruction of M cells and intracellular survival but not for invasion or colonization of the murine small intestine.
Infection and immunity 1996;64(12):5075-84.
1996: Ivaylo Gentschev; Hans-Joachim Mollenkopf; Z Sokolovic; Juergen H Hess; Stefan H E Kaufmann; Werner Goebel
Development of antigen-delivery systems, based on the Escherichia coli hemolysin secretion pathway.
Gene 1996;179(1):133-40.
1996: R Böckmann; C Dickneite; B Middendorf; Werner Goebel; Z Sokolovic
Specific binding of the Listeria monocytogenes transcriptional regulator PrfA to target sequences requires additional factor(s) and is influenced by iron.
Molecular microbiology 1996;22(4):643-53.
1996: Hans-Joachim Mollenkopf; Ivaylo Gentschev; Werner Goebel
Conversion of bacterial gene products to secretion-competent fusion proteins.
BioTechniques 1996;21(5):854, 856-60.
1996: Z Sokolovic; Stephanie Schuller; J Bohne; A Baur; U Rdest; C Dickneite; Thomas Nichterlein; Werner Goebel
Differences in virulence and in expression of PrfA and PrfA-regulated virulence genes of Listeria monocytogenes strains belonging to serogroup 4.
Infection and immunity 1996;64(10):4008-19.
1996: Ivaylo Gentschev; G Maier; A Kranig; Werner Goebel
Mini-TnhlyAs: a new tool for the construction of secreted fusion proteins.
Molecular & general genetics : MGG 1996;252(3):266-74.
1996: A Döbereiner; A Schmid; Albrecht Ludwig; Werner Goebel; Roland Benz
The effects of calcium and other polyvalent cations on channel formation by Escherichia coli alpha-hemolysin in red blood cells and lipid bilayer membranes.
European journal of biochemistry / FEBS 1996;240(2):454-60.
1996: Albrecht Ludwig; F Garcia; S Bauer; Thomas Jarchau; Roland Benz; J Hoppe; Werner Goebel
Analysis of the in vivo activation of hemolysin (HlyA) from Escherichia coli.
Journal of bacteriology 1996;178(18):5422-30.
1996: A Demuth; Werner Goebel; H U Beuscher; Michael Kuhn
Differential regulation of cytokine and cytokine receptor mRNA expression upon infection of bone marrow-derived macrophages with Listeria monocytogenes.
Infection and immunity 1996;64(9):3475-83.
1996: Fredi Engelbrecht; S K Chun; C Ochs; Juergen H Hess; F Lottspeich; Werner Goebel; Z Sokolovic
A new PrfA-regulated gene of Listeria monocytogenes encoding a small, secreted protein which belongs to the family of internalins.
Molecular microbiology 1996;21(4):823-37.
1996: D Schröder; H Deppisch; M Obermayer; G Krohne; E Stackebrandt; B Hôlldobler; Werner Goebel; Roy Gross
Intracellular endosymbiotic bacteria of Camponotus species (carpenter ants): systematics, evolution and ultrastructural characterization.
Molecular microbiology 1996;21(3):479-89.
1996: Juergen H Hess; A Dreher; Ivaylo Gentschev; Werner Goebel; CH Ladel; D Miko; Stefan H E Kaufmann
Protein p60 participates in intestinal host invasion by Listeria monocytogenes.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1996;284(2-3):263-72.
1996: J Bohne; H Kestler; C Uebele; Z Sokolovic; Werner Goebel
Differential regulation of the virulence genes of Listeria monocytogenes by the transcriptional activator PrfA.
Molecular microbiology 1996;20(6):1189-98.
1996: Hans-Joachim Mollenkopf; Ivaylo Gentschev; A Bubert; P Schubert; Werner Goebel
Extracellular PagC-HlyAs fusion protein for the generation and identification of Salmonella-specific antibodies.
Applied microbiology and biotechnology 1996;45(5):629-37.
1996: Juergen H Hess; Ivaylo Gentschev; D Miko; M Welzel; CH Ladel; Werner Goebel; Stefan H E Kaufmann
Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1458-63.
1996: WR Schwan; S Kügler; Stephanie Schuller; Dennis J Kopecko; Werner Goebel
Detection and characterization by differential PCR of host eukaryotic cell genes differentially transcribed following uptake of intracellular bacteria.
Infection and immunity 1996;64(1):91-9.
1995: Albrecht Ludwig; C Tengel; S Bauer; A Bubert; Roland Benz; Hans-Joachim Mollenkopf; Werner Goebel
SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coli.
Molecular & general genetics : MGG 1995;249(5):474-86.
1995: Ivaylo Gentschev; Z Sokolovic; Hans-Joachim Mollenkopf; Juergen H Hess; Stefan H E Kaufmann; Michael Kuhn; G F Krohne; Werner Goebel
Salmonella strain secreting active listeriolysin changes its intracellular localization.
Infection and immunity 1995;63(10):4202-5.
1995: Juergen H Hess; Ivaylo Gentschev; Gudrun Szalay; CH Ladel; A Bubert; Werner Goebel; Stefan H E Kaufmann
Listeria monocytogenes p60 supports host cell invasion by and in vivo survival of attenuated Salmonella typhimurium.
Infection and immunity 1995;63(5):2047-53.
1995: Michael Kuhn; Werner Goebel
Molecular studies on the virulence of Listeria monocytogenes.
Genetic engineering 1995;17():31-51.
1994: Juergen H Hess; Gudrun Szalay; D Miko; Ivaylo Gentschev; Werner Goebel; CH Ladel; Stefan H E Kaufmann
Vaccination strategies using viable carrier systems against intracellular pathogens.
Behring Institute Mitteilungen 1994;(95):67-79.
1994: Ivaylo Gentschev; Hans-Joachim Mollenkopf; Z Sokolovic; Albrecht Ludwig; C Tengel; Roy Gross; Juergen H Hess; A Demuth; Werner Goebel
Synthesis and secretion of bacterial antigens by attenuated Salmonella via the Escherichia coli hemolysin secretion system.
Behring Institute Mitteilungen 1994;(95):57-66.
1994: A Demuth; Trinad Chakraborty; G Krohne; Werner Goebel
Mammalian cells transfected with the listeriolysin gene exhibit enhanced proliferation and focus formation.
Infection and immunity 1994;62(11):5102-11.
1994: WR Schwan; A Demuth; Michael Kuhn; Werner Goebel
Phosphatidylinositol-specific phospholipase C from Listeria monocytogenes contributes to intracellular survival and growth of Listeria innocua.
Infection and immunity 1994;62(11):4795-803.
1994: R Schülein; Ivaylo Gentschev; S Schlör; Roy Gross; Werner Goebel
Identification and characterization of two functional domains of the hemolysin translocator protein HlyD.
Molecular & general genetics : MGG 1994;245(2):203-11.
1994: T Jarchau; Trinad Chakraborty; F Garcia; Werner Goebel
Selection for transport competence of C-terminal polypeptides derived from Escherichia coli hemolysin: the shortest peptide capable of autonomous HlyB/HlyD-dependent secretion comprises the C-terminal 62 amino acids of HlyA.
Molecular & general genetics : MGG 1994;245(1):53-60.
1994: A Bubert; P Schubert; S Köhler; R Frank; Werner Goebel
Synthetic peptides derived from the Listeria monocytogenes p60 protein as antigens for the generation of polyclonal antibodies specific for secreted cell-free L. monocytogenes p60 proteins.
Applied and environmental microbiology 1994;60(9):3120-7.
1994: I Karunasagar; B Senghaas; G Krohne; Werner Goebel
Ultrastructural study of Listeria monocytogenes entry into cultured human colonic epithelial cells.
Infection and immunity 1994;62(8):3554-8.
1994: WR Schwan; Werner Goebel
Host cell responses to Listeria monocytogenes infection include differential transcription of host stress genes involved in signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6428-32.
1994: N Hauf; Werner Goebel; Edgar Serfling; Michael Kuhn
Listeria monocytogenes infection enhances transcription factor NF-kappa B in P388D1 macrophage-like cells.
Infection and immunity 1994;62(7):2740-7.
1994: Robert Lampidis; Roy Gross; Z Sokolovic; Werner Goebel; Jürgen Kreft
The virulence regulator protein of Listeria ivanovii is highly homologous to PrfA from Listeria monocytogenes and both belong to the Crp-Fnr family of transcription regulators.
Molecular microbiology 1994;13(1):141-51.
1994: J Bohne; Z Sokolovic; Werner Goebel
Transcriptional regulation of prfA and PrfA-regulated virulence genes in Listeria monocytogenes.
Molecular microbiology 1994;11(6):1141-50.
1994: Michael Kuhn; Werner Goebel
Induction of cytokines in phagocytic mammalian cells infected with virulent and avirulent Listeria strains.
Infection and immunity 1994;62(2):348-56.
1993: Albrecht Ludwig; Roland Benz; Werner Goebel
Oligomerization of Escherichia coli haemolysin (HlyA) is involved in pore formation.
Molecular & general genetics : MGG 1993;241(1-2):89-96.
1993: M D Wuenscher; S Köhler; A Bubert; U Gerike; Werner Goebel
The iap gene of Listeria monocytogenes is essential for cell viability, and its gene product, p60, has bacteriolytic activity.
Journal of bacteriology 1993;175(11):3491-501.
1993: Werner Goebel; M Leimeister-Wächter; Michael Kuhn; Eugen Domann; Trinad Chakraborty; S Köhler; A Bubert; M Wuenscher; Z Sokolovic
Listeria monocytogenes--a model system for studying the pathomechanisms of an intracellular microorganism.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1993;278(2-3):334-47.
1993: Z Sokolovic; J Riedel; M Wuenscher; Werner Goebel
Surface-associated, PrfA-regulated proteins of Listeria monocytogenes synthesized under stress conditions.
Molecular microbiology 1993;8(2):219-27.
1993: I Karunasagar; G Krohne; Werner Goebel
Listeria ivanovii is capable of cell-to-cell spread involving actin polymerization.
Infection and immunity 1993;61(1):162-9.
1992: A Bubert; Michael Kuhn; Werner Goebel; S Köhler
Structural and functional properties of the p60 proteins from different Listeria species.
Journal of bacteriology 1992;174(24):8166-71.
1992: Ivaylo Gentschev; Z Sokolovic; S Köhler; G F Krohne; H Hof; J Wagner; Werner Goebel
Identification of p60 antibodies in human sera and presentation of this listerial antigen on the surface of attenuated salmonellae by the HlyB-HlyD secretion system.
Infection and immunity 1992;60(12):5091-8.
1992: Klaus Brehm; A Haas; Werner Goebel; Jürgen Kreft
A gene encoding a superoxide dismutase of the facultative intracellular bacterium Listeria monocytogenes.
Gene 1992;118(1):121-5.
1992: W Wels; M Baldrich; Trinad Chakraborty; Roy Gross; Werner Goebel
Expression of bacterial cytotoxin genes in mammalian target cells.
Molecular microbiology 1992;6(18):2651-9.
1992: Roland Benz; A Döbereiner; Albrecht Ludwig; Werner Goebel
Haemolysin of Escherichia coli: comparison of pore-forming properties between chromosome and plasmid-encoded haemolysins.
FEMS microbiology immunology 1992;5(1-3):55-62.
1992: A Bubert; S Köhler; Werner Goebel
The homologous and heterologous regions within the iap gene allow genus- and species-specific identification of Listeria spp. by polymerase chain reaction.
Applied and environmental microbiology 1992;58(8):2625-32.
1992: R Schülein; Ivaylo Gentschev; Hans-Joachim Mollenkopf; Werner Goebel
A topological model for the haemolysin translocator protein HlyD.
Molecular & general genetics : MGG 1992;234(1):155-63.
1992: C Hanke; Juergen H Hess; G Schumacher; Werner Goebel
Processing by OmpT of fusion proteins carrying the HlyA transport signal during secretion by the Escherichia coli hemolysin transport system.
Molecular & general genetics : MGG 1992;233(1-2):42-8.
1992: Eugen Domann; Jürgen Wehland; Manfred Rohde; S Pistor; M Hartl; Werner Goebel; M Leimeister-Wächter; M Wuenscher; Trinad Chakraborty
A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin.
The EMBO journal 1992;11(5):1981-90.
1992: Ivaylo Gentschev; Werner Goebel
Topological and functional studies on HlyB of Escherichia coli.
Molecular & general genetics : MGG 1992;232(1):40-8.
1992: R L Oropeza-Wekerle; S Muller; J P Briand; Roland Benz; A Schmid; Werner Goebel
Haemolysin-derived synthetic peptides with pore-forming and haemolytic activity.
Molecular microbiology 1992;6(1):115-21.
1992: A Haas; Werner Goebel
Cloning of a superoxide dismutase gene from Listeria ivanovii by functional complementation in Escherichia coli and characterization of the gene product.
Molecular & general genetics : MGG 1992;231(2):313-22.
1992: Trinad Chakraborty; M Leimeister-Wächter; Eugen Domann; M Hartl; Werner Goebel; T Nichterlein; S Notermans
Coordinate regulation of virulence genes in Listeria monocytogenes requires the product of the prfA gene.
Journal of bacteriology 1992;174(2):568-74.
1992: A Haas; Werner Goebel
Microbial strategies to prevent oxygen-dependent killing by phagocytes.
Free radical research communications 1992;16(3):137-57.
1992: Jörg Hacker; M Ott; G Blum; R Marre; Jürgen Heesemann; Helmut Tschäpe; Werner Goebel
Genetics of Escherichia coli uropathogenicity: analysis of the O6:K15:H31 isolate 536.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1992;276(2):165-75.
1991: M D Wuenscher; S Köhler; Werner Goebel; Trinad Chakraborty
Gene disruption by plasmid integration in Listeria monocytogenes: insertional inactivation of the listeriolysin determinant lisA.
Molecular & general genetics : MGG 1991;228(1-2):177-82.
1991: S Köhler; A Bubert; M Vogel; Werner Goebel
Expression of the iap gene coding for protein p60 of Listeria monocytogenes is controlled on the posttranscriptional level.
Journal of bacteriology 1991;173(15):4668-74.
1991: A Haas; Klaus Brehm; Jürgen Kreft; Werner Goebel
Cloning, characterization, and expression in Escherichia coli of a gene encoding Listeria seeligeri catalase, a bacterial enzyme highly homologous to mammalian catalases.
Journal of bacteriology 1991;173(16):5159-67.
1991: R Schülein; Jürgen Kreft; S Gonski; Werner Goebel
Preprosubtilisin Carlsberg processing and secretion is blocked after deletion of amino acids 97-101 in the mature part of the enzyme.
Molecular & general genetics : MGG 1991;227(1):137-43.
1991: R L Oropeza-Wekerle; P Kern; D Sun; S Muller; J P Briand; Werner Goebel
Characterization of monoclonal antibodies against alpha-hemolysin of Escherichia coli.
Infection and immunity 1991;59(5):1846-52.
1991: Albrecht Ludwig; A Schmid; Roland Benz; Werner Goebel
Mutations affecting pore formation by haemolysin from Escherichia coli.
Molecular & general genetics : MGG 1991;226(1-2):198-208.
1991: Werner Goebel; Trinad Chakraborty; Eugen Domann; S Köhler; Michael Kuhn; M Leimeister-Wächter; Z Sokolovic; M Wuenscher
Studies on the pathogenicity of Listeria monocytogenes.
Infection 1991;19 Suppl 4():S195-7.
1991: Eugen Domann; M Leimeister-Wächter; Werner Goebel; Trinad Chakraborty
Molecular cloning, sequencing, and identification of a metalloprotease gene from Listeria monocytogenes that is species specific and physically linked to the listeriolysin gene.
Infection and immunity 1991;59(1):65-72.
1991: A Haas; Werner Goebel
Cloning and expression in Escherichia coli of a gene encoding superoxide dismutase from Listeria ivanovii.
Free radical research communications 1991;12-13 Pt 1():371-7.
1990: Juergen H Hess; Ivaylo Gentschev; Werner Goebel; Thomas Jarchau
Analysis of the haemolysin secretion system by PhoA-HlyA fusion proteins.
Molecular & general genetics : MGG 1990;224(2):201-8.
1990: M Leimeister-Wächter; C Haffner; Eugen Domann; Werner Goebel; Trinad Chakraborty
Identification of a gene that positively regulates expression of listeriolysin, the major virulence factor of listeria monocytogenes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8336-40.
1990: Z Sokolovic; A Fuchs; Werner Goebel
Synthesis of species-specific stress proteins by virulent strains of Listeria monocytogenes.
Infection and immunity 1990;58(11):3582-7.
1990: Ivaylo Gentschev; Juergen H Hess; Werner Goebel
Change in the cellular localization of alkaline phosphatase by alteration of its carboxy-terminal sequence.
Molecular & general genetics : MGG 1990;222(2-3):211-6.
1990: R L Oropeza-Wekerle; W Speth; B Imhof; Ivaylo Gentschev; Werner Goebel
Translocation and compartmentalization of Escherichia coli hemolysin (HlyA).
Journal of bacteriology 1990;172(7):3711-7.
1990: S Göhmann; M Leimeister-Wächter; E Schiltz; Werner Goebel; Trinad Chakraborty
Characterization of a Listeria monocytogenes-specific protein capable of inducing delayed hypersensitivity in Listeria-immune mice.
Molecular microbiology 1990;4(7):1091-9.
1990: S Köhler; M Leimeister-Wächter; Trinad Chakraborty; F Lottspeich; Werner Goebel
The gene coding for protein p60 of Listeria monocytogenes and its use as a specific probe for Listeria monocytogenes.
Infection and immunity 1990;58(6):1943-50.
1990: M Baldrich; Werner Goebel
Rapid and efficient site-specific mutagenesis.
Protein engineering 1990;3(6):563.
1990: Jörg Hacker; L Bender; M Ott; J Wingender; B Lund; R Marre; Werner Goebel
Deletions of chromosomal regions coding for fimbriae and hemolysins occur in vitro and in vivo in various extraintestinal Escherichia coli isolates.
Microbial pathogenesis 1990;8(3):213-25.
1989: M Leimeister-Wächter; Werner Goebel; Trinad Chakraborty
Mutations affecting hemolysin production in Listeria monocytogenes located outside the listeriolysin gene.
FEMS microbiology letters 1989;53(1-2):23-9.
1989: R L Oropeza-Wekerle; E Müller; P Kern; Richard Meyermann; Werner Goebel
Synthesis, inactivation, and localization of extracellular and intracellular Escherichia coli hemolysins.
Journal of bacteriology 1989;171(5):2783-8.
1989: Roland Benz; A Schmid; W Wagner; Werner Goebel
Pore formation by the Escherichia coli hemolysin: evidence for an association-dissociation equilibrium of the pore-forming aggregates.
Infection and immunity 1989;57(3):887-95.
1989: Michael S Gilmore; Armando Cruz-Rodz; M Leimeister-Wächter; Jürgen Kreft; Werner Goebel
A Bacillus cereus cytolytic determinant, cereolysin AB, which comprises the phospholipase C and sphingomyelinase genes: nucleotide sequence and genetic linkage.
Journal of bacteriology 1989;171(2):744-53.
1989: Jürgen Kreft; D Funke; A Haas; F Lottspeich; Werner Goebel
Production, purification and characterization of hemolysins from Listeria ivanovii and Listeria monocytogenes Sv4b.
FEMS microbiology letters 1989;48(2):197-202.
1989: A Haas; Jürgen Kreft; Werner Goebel
Isolation and characterization of genes coding for proteins involved in the cytolysis by Listeria ivanovii.
Acta microbiologica Hungarica 1989;36(2-3):183-7.
1989: Jürgen Kreft; D Funke; R Schlesinger; F Lottspeich; Werner Goebel
Purification and characterization of cytolysins from Listeria monocytogenes serovar 4b and Listeria ivanovii.
Acta microbiologica Hungarica 1989;36(2-3):189-92.
1989: Michael Kuhn; Werner Goebel
Identification of an extracellular protein of Listeria monocytogenes possibly involved in intracellular uptake by mammalian cells.
Infection and immunity 1989;57(1):55-61.
1989: Z Sokolovic; Werner Goebel
Synthesis of listeriolysin in Listeria monocytogenes under heat shock conditions.
Infection and immunity 1989;57(1):295-8.
1988: Albrecht Ludwig; Thomas Jarchau; Roland Benz; Werner Goebel
The repeat domain of Escherichia coli haemolysin (HlyA) is responsible for its Ca2+-dependent binding to erythrocytes.
Molecular & general genetics : MGG 1988;214(3):553-61.
1988: V Husslein; B Huhle; Thomas Jarchau; R Lurz; Werner Goebel; Trinad Chakraborty
Nucleotide sequence and transcriptional analysis of the aerCaerA region of Aeromonas sobria encoding aerolysin and its regulatory region.
Molecular microbiology 1988;2(4):507-17.
1988: B Surek; B Pillay; U Rdest; Konrad Beyreuther; Werner Goebel
Evidence for two different gas vesicle proteins and genes in Halobacterium halobium.
Journal of bacteriology 1988;170(4):1746-51.
1988: M Vogel; Juergen H Hess; I Then; A Juarez; Werner Goebel
Characterization of a sequence (hlyR) which enhances synthesis and secretion of hemolysin in Escherichia coli.
Molecular & general genetics : MGG 1988;212(1):76-84.
1988: S Kathariou; J Rocourt; H Hof; Werner Goebel
Levels of Listeria monocytogenes hemolysin are not directly proportional to virulence in experimental infections of mice.
Infection and immunity 1988;56(2):534-6.
1988: W Wagner; Michael Kuhn; Werner Goebel
Active and inactive forms of hemolysin (HlyA) from Escherichia coli.
Biological chemistry Hoppe-Seyler 1988;369(1):39-46.
1988: Werner Goebel; Trinad Chakraborty; Jürgen Kreft
Bacterial hemolysins as virulence factors.
Antonie van Leeuwenhoek 1988;54(5):453-63.
1988: Werner Goebel; S Kathariou; Michael Kuhn; Z Sokolovic; Jürgen Kreft; S Köhler; D Funke; Trinad Chakraborty; M Leimeister-Wächter
Hemolysin from Listeria--biochemistry, genetics and function in pathogenesis.
Infection 1988;16 Suppl 2():S149-56.
1988: Michael Kuhn; S Kathariou; Werner Goebel
Hemolysin supports survival but not entry of the intracellular bacterium Listeria monocytogenes.
Infection and immunity 1988;56(1):79-82.
1987: L Pine; R E Weaver; George M Carlone; P A Pienta; J Rocourt; Werner Goebel; S Kathariou; William Bibb; G B Malcolm
Listeria monocytogenes ATCC 35152 and NCTC 7973 contain a nonhemolytic, nonvirulent variant.
Journal of clinical microbiology 1987;25(11):2247-51.
1987: Trinad Chakraborty; S Kathariou; Jörg Hacker; H Hof; B Huhle; W Wagner; Michael Kuhn; Werner Goebel
Molecular analysis of bacterial cytolysins.
Reviews of infectious diseases 1987;9 Suppl 5():S456-66.
1987: S Kathariou; P Metz; H Hof; Werner Goebel
Tn916-induced mutations in the hemolysin determinant affecting virulence of Listeria monocytogenes.
Journal of bacteriology 1987;169(3):1291-7.
1987: C Hughes; Jörg Hacker; H Düvel; Werner Goebel
Chromosomal deletions and rearrangements cause coordinate loss of haemolysis, fimbriation and serum resistance in a uropathogenic strain of Escherichia coli.
Microbial pathogenesis 1987;2(3):227-30.
1986: Jörg Hacker; H Hof; Levente Emödy; Werner Goebel
Influence of cloned Escherichia coli hemolysin genes, S-fimbriae and serum resistance on pathogenicity in different animal models.
Microbial pathogenesis 1986;1(6):533-47.
1985: S Knapp; I Then; W Wels; G Michel; H Tschäpe; J Hacker; Werner Goebel
Analysis of the flanking regions from different haemolysin determinants of Escherichia coli.
Molecular & general genetics : MGG 1985;200(3):385-92.
1985: Werner Goebel; J Hacker; S Knapp; I Then; W Wagner; C Hughes; A Juarez
Structure, function, and regulation of the plasmid-encoded hemolysin determinant of Escherichia coli.
Basic life sciences 1985;30():791-805.
1984: S Knapp; J Hacker; I Then; D Müller; Werner Goebel
Multiple copies of hemolysin genes and associated sequences in the chromosomes of uropathogenic Escherichia coli strains.
Journal of bacteriology 1984;159(3):1027-33.