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Michel Goedert

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Yamashita Makiko; Nonaka Takashi; Arai Tetsuaki; Kametani Fuyuki; Buchman Vladimir L; Ninkina Natalia; Bachurin Sergey O; Akiyama Haruhiko; Goedert Michel; Hasegawa Masato
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.
Clavaguera Florence; Bolmont Tristan; Crowther R Anthony; Abramowski Dorothee; Frank Stephan; Probst Alphonse; Fraser Graham; Stalder Anna K; Beibel Martin; Staufenbiel Matthias; Jucker Mathias; Goedert Michel; Tolnay Markus
Transmission and spreading of tauopathy in transgenic mouse brain.
Goedert Michel
Oskar Fischer and the study of dementia.

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All Publications

2009: Yamashita Makiko; Nonaka Takashi; Arai Tetsuaki; Kametani Fuyuki; Buchman Vladimir L; Ninkina Natalia; Bachurin Sergey O; Akiyama Haruhiko; Goedert Michel; Hasegawa Masato
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models.
FEBS letters 2009;583(14):2419-24.
2009: Clavaguera Florence; Bolmont Tristan; Crowther R Anthony; Abramowski Dorothee; Frank Stephan; Probst Alphonse; Fraser Graham; Stalder Anna K; Beibel Martin; Staufenbiel Matthias; Jucker Mathias; Goedert Michel; Tolnay Markus
Transmission and spreading of tauopathy in transgenic mouse brain.
Nature cell biology 2009;11(7):909-13.
2009: Goedert Michel
Oskar Fischer and the study of dementia.
Brain : a journal of neurology 2009;132(Pt 4):1102-11.
2009: Masuda Masami; Hasegawa Masato; Nonaka Takashi; Oikawa Takayuki; Yonetani Motokuni; Yamaguchi Yoshiki; Kato Koichi; Hisanaga Shin-Ichi; Goedert Michel
Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.
FEBS letters 2009;583(4):787-91.
2008: Kovacs Gabor G; Majtenyi Katalin; Spina Salvatore; Murrell Jill R; Gelpi Ellen; Hoftberger Romana; Fraser Graham; Crowther R Anthony; Goedert Michel; Budka Herbert; Ghetti Bernardino
White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration.
Journal of neuropathology and experimental neurology 2008;67(10):963-75.
2008: Ye Liang; Velasco Ana; Fraser Graham; Beach Thomas G; Sue Lucia; Osredkar Tracy; Libri Vincenzo; Spillantini Maria Grazia; Goedert Michel; Lockhart Andrew
In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain.
Journal of neurochemistry 2008;105(4):1428-37.
2008: Velasco Ana; Fraser Graham; Delobel Patrice; Ghetti Bernardino; Lavenir Isabelle; Goedert Michel
Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene].
FEBS letters 2008;582(6):901-6.
2008: Radde Rebecca; Duma Cecilia; Goedert Michel; Jucker Mathias
The value of incomplete mouse models of Alzheimer's disease.
European journal of nuclear medicine and molecular imaging 2008;35 Suppl 1():S70-4.
2008: Delobel Patrice; Lavenir Isabelle; Fraser Graham; Ingram Esther; Holzer Max; Ghetti Bernardino; Spillantini Maria Grazia; Crowther R Anthony; Goedert Michel
Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy.
The American journal of pathology 2008;172(1):123-31.
2008: Spina Salvatore; Farlow Martin R; Unverzagt Frederick W; Kareken David A; Murrell Jill R; Fraser Graham; Epperson Francine; Crowther R Anthony; Spillantini Maria G; Goedert Michel; Ghetti Bernardino
The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family.
Brain : a journal of neurology 2008;131(Pt 1):72-89.
2007: Zibaee Shahin; Jakes Ross; Fraser Graham; Serpell Louise C; Crowther R Anthony; Goedert Michel
Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein.
Journal of molecular biology 2007;374(2):454-64.
2007: Magnani Enrico; Fan Juan; Gasparini Laura; Golding Matthew; Williams Meredith; Schiavo Giampietro; Goedert Michel; Amos Linda A; Spillantini Maria Grazia
Interaction of tau protein with the dynactin complex.
The EMBO journal 2007;26(21):4546-54.
2007: Ishii Aasami; Nonaka Takashi; Taniguchi Sayuri; Saito Taro; Arai Tetsuaki; Mann David; Iwatsubo Takeshi; Hisanaga Shin-Ichi; Goedert Michel; Hasegawa Masato
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.
FEBS letters 2007;581(24):4711-7.
2007: Virdee Kanwar; Yoshida Hirotaka; Peak-Chew Sew; Goedert Michel
Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.
FEBS letters 2007;581(14):2657-62.
2007: Zibaee Shahin; Makin O Sumner; Goedert Michel; Serpell Louise C
A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone.
Protein science : a publication of the Protein Society 2007;16(5):906-18.
2007: Spina Salvatore; Murrell Jill R; Yoshida Hirotaka; Ghetti Bernardino; Bermingham Niamh; Sweeney Brian; Dlouhy Stephen R; Crowther R Anthony; Goedert Michel; Keohane Catherine
The novel Tau mutation G335S: clinical, neuropathological and molecular characterization.
Acta neuropathologica 2007;113(4):461-70.
2007: Goedert Michel; Ghetti Bernardino
Alois Alzheimer: his life and times.
Brain pathology (Zurich, Switzerland) 2007;17(1):57-62.
2006: Broersen Kerensa; van den Brink Daan; Fraser Graham; Goedert Michel; Davletov Bazbek
Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.
Biochemistry 2006;45(51):15610-6.
2006: Goedert Michel; Spillantini Maria Grazia
A century of Alzheimer's disease.
Science (New York, N.Y.) 2006;314(5800):777-81.
2006: Goedert Michel; Spillantini Maria Grazia
Frontotemporal lobar degeneration through loss of progranulin function.
Brain : a journal of neurology 2006;129(Pt 11):2808-10.
2006: Yoshida Hirotaka; Goedert Michel
Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.
Journal of neurochemistry 2006;99(1):154-64.
2006: Masuda Masami; Suzuki Nobuyuki; Taniguchi Sayuri; Oikawa Takayuki; Nonaka Takashi; Iwatsubo Takeshi; Hisanaga Shin-ichi; Goedert Michel; Hasegawa Masato
Small molecule inhibitors of alpha-synuclein filament assembly.
Biochemistry 2006;45(19):6085-94.
2006: Tofaris George K; Garcia Reitböck Pablo; Humby Trevor; Lambourne Sarah L; O'Connell Mark; Ghetti Bernardino; Gossage Helen; Emson Piers C; Wilkinson Lawrence S; Goedert Michel; Spillantini Maria Grazia
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(15):3942-50.
2006: Masuda Masami; Dohmae Naoshi; Nonaka Takashi; Oikawa Takayuki; Hisanaga Shin-ichi; Goedert Michel; Hasegawa Masato
Cysteine misincorporation in bacterially expressed human alpha-synuclein.
FEBS letters 2006;580(7):1775-9.
2006: Delobel Patrice; Lavenir Isabelle; Ghetti Bernardino; Holzer Max; Goedert Michel
Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1.
The American journal of pathology 2006;168(3):878-87.
2006: Yoshida Hirotaka; Craxton Molly; Jakes Ross; Zibaee Shahin; Tavaré Richard; Fraser Graham; Serpell Louise C; Davletov Bazbek; Crowther R Anthony; Goedert Michel
Synuclein proteins of the pufferfish Fugu rubripes: sequences and functional characterization.
Biochemistry 2006;45(8):2599-607.
2006: Spillantini Maria Grazia; Murrell Jill R; Goedert Michel; Farlow Martin; Klug Aaron; Ghetti Bernardino
Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD).
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):373-80.
2006: Goedert Michel; Klug Aaron; Crowther R Anthony
Tau protein, the paired helical filament and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):195-207.
2005: Yamaguchi Keiji; Cochran Elizabeth J; Murrell Jill R; Polymeropoulos Mihael H; Shannon Kathleen M; Crowther R Anthony; Goedert Michel; Ghetti Bernardino
Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene.
Acta neuropathologica 2005;110(3):298-305.
2005: Goedert Michel
Tau gene mutations and their effects.
Movement disorders : official journal of the Movement Disorder Society 2005;20 Suppl 12():S45-52.
2005: Sabio Guadalupe; Arthur James Simon Campbell; Kuma Yvonne; Peggie Mark; Carr Julia; Murray-Tait Vicky; Centeno Francisco; Goedert Michel; Morrice Nicholas A; Cuenda Ana
p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.
The EMBO journal 2005;24(6):1134-45.
2005: Taniguchi Sayuri; Suzuki Nobuyuki; Masuda Masami; Hisanaga Shin-ichi; Iwatsubo Takeshi; Goedert Michel; Hasegawa Masato
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.
The Journal of biological chemistry 2005;280(9):7614-23.
2005: Feijoo Carmen; Campbell David G; Jakes Ross; Goedert Michel; Cuenda Ana
Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.
Journal of cell science 2005;118(Pt 2):397-408.
2005: Goedert Michel; Jakes Ross
Mutations causing neurodegenerative tauopathies.
Biochimica et biophysica acta 2005;1739(2-3):240-50.
2004: Bellucci Arianna; Westwood Andrew J; Ingram Esther; Casamenti Fiorella; Goedert Michel; Spillantini Maria Grazia
Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein.
The American journal of pathology 2004;165(5):1643-52.
2004: Choi Woong; Zibaee Shahin; Jakes Ross; Serpell Louise C; Davletov Bazbek; Crowther R Anthony; Goedert Michel
Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.
FEBS letters 2004;576(3):363-8.
2004: Holzer Max; Craxton Molly; Jakes Ross; Arendt Thomas; Goedert Michel
Tau gene (MAPT) sequence variation among primates.
Gene 2004;341():313-22.
2004: Yoshida Hirotaka; Hastie C James; McLauchlan Hilary; Cohen Philip; Goedert Michel
Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).
Journal of neurochemistry 2004;90(2):352-8.
2004: Cohen Philip; Goedert Michel
GSK3 inhibitors: development and therapeutic potential.
Nature reviews. Drug discovery 2004;3(6):479-87.
2004: Sabio Guadalupe; Reuver Suzana; Feijoo Carmen; Hasegawa Masato; Thomas Gareth M; Centeno Francisco; Kuhlendahl Sven; Leal-Ortiz Sergio; Goedert Michel; Garner Craig; Cuenda Ana
Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.
The Biochemical journal 2004;380(Pt 1):19-30.
2004: Takao Masaki; Ghetti Bernardino; Yoshida Hirotaka; Piccardo Pedro; Narain Yolanda; Murrell Jill R; Vidal Ruben; Glazier Bradley S; Jakes Ross; Tsutsui Miho; Spillantini Maria Grazia; Crowther R Anthony; Goedert Michel; Koto Atsuo
Early-onset dementia with Lewy bodies.
Brain pathology (Zurich, Switzerland) 2004;14(2):137-47.
2004: Goedert Michel
Tau protein and neurodegeneration.
Seminars in cell & developmental biology 2004;15(1):45-9.
2003: van Herpen Esther; Rosso Sonia M; Serverijnen Lies-Anne; Yoshida Hirotaka; Breedveld Guido; van de Graaf Raoul; Kamphorst Wouter; Ravid Rivka; Willemsen Rob; Dooijes Dennis; Majoor-Krakauer Daniëlle; Kros Johan M; Crowther R Anthony; Goedert Michel; Heutink Peter; van Swieten John C
Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R.
Annals of neurology 2003;54(5):573-81.
2003: Goedert Michel
Neurodegenerative tauopathy in the worm.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9653-5.
2003: Berriman John; Serpell Louise C; Oberg Keith A; Fink Anthony L; Goedert Michel; Crowther R Anthony
Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):9034-8.
2003: Kar Santwana; Fan Juan; Smith Michael J; Goedert Michel; Amos Linda A
Repeat motifs of tau bind to the insides of microtubules in the absence of taxol.
The EMBO journal 2003;22(1):70-7.
2002: Yoshida Hirotaka; Goedert Michel
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Biochemistry 2002;41(51):15203-11.
2002: Allen Bridget; Ingram Esther; Takao Masaki; Smith Michael J; Jakes Ross; Virdee Kanwar; Yoshida Hirotaka; Holzer Max; Craxton Molly; Emson Piers C; Atzori Cristiana; Migheli Antonio; Crowther R Anthony; Ghetti Bernardino; Spillantini Maria Grazia; Goedert Michel
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(21):9340-51.
2002: David Della C; Layfield Robert; Serpell Louise; Narain Yolanda; Goedert Michel; Spillantini Maria Grazia
Proteasomal degradation of tau protein.
Journal of neurochemistry 2002;83(1):176-85.
2002: Uversky Vladimir N; Li Jie; Souillac Pierre; Millett Ian S; Doniach Sebastian; Jakes Ross; Goedert Michel; Fink Anthony L
Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins.
The Journal of biological chemistry 2002;277(14):11970-8.
2002: Buée-Scherrer Valérie; Goedert Michel
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells.
FEBS letters 2002;515(1-3):151-4.
2002: Rosso Sonia M; van Herpen Esther; Deelen Wout; Kamphorst Wouter; Severijnen Lies-Anne; Willemsen Rob; Ravid Rivka; Niermeijer Martinus F; Dooijes Dennis; Smith Michael J; Goedert Michel; Heutink Peter; van Swieten John C
A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease.
Annals of neurology 2002;51(3):373-6.
2002: Delobel Patrice; Flament Stéphane; Hamdane Malika; Jakes Ross; Rousseau Arlette; Delacourte André; Vilain Jean-Pierre; Goedert Michel; Buée Luc
Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation.
The Journal of biological chemistry 2002;277(11):9199-205.
2002: Yoshida Hirotaka; Crowther R Anthony; Goedert Michel
Functional effects of tau gene mutations deltaN296 and N296H.
Journal of neurochemistry 2002;80(3):548-51.
2002: Syme Christopher D; Blanch Ewan W; Holt Carl; Jakes Ross; Goedert Michel; Hecht Lutz; Barron Laurence D
A Raman optical activity study of rheomorphism in caseins, synucleins and tau. New insight into the structure and behaviour of natively unfolded proteins.
European journal of biochemistry / FEBS 2002;269(1):148-56.
2001: Spillantini M G; Goedert M
Tau and Parkinson disease.
JAMA : the journal of the American Medical Association 2001;286(18):2324-6.
2001: Neumann M; Schulz-Schaeffer W; Crowther R A; Smith M J; Spillantini M G; Goedert M; Kretzschmar H A
Pick's disease associated with the novel Tau gene mutation K369I.
Annals of neurology 2001;50(4):503-13.
2001: Hartmann A M; Rujescu D; Giannakouros T; Nikolakaki E; Goedert M; Mandelkow E M; Gao Q S; Andreadis A; Stamm S
Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors.
Molecular and cellular neurosciences 2001;18(1):80-90.
2001: Goedert M
Alpha-synuclein and neurodegenerative diseases.
Nature reviews. Neuroscience 2001;2(7):492-501.
2001: Goedert M
The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases.
Current opinion in genetics & development 2001;11(3):343-51.
2001: Woods Y L; Cohen P; Becker W; Jakes R; Goedert M; Wang X; Proud C G
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
The Biochemical journal 2001;355(Pt 3):609-15.
2001: Goedert M
Parkinson's disease and other alpha-synucleinopathies.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2001;39(4):308-12.
2001: Goedert M; Spillantini M G; Serpell L C; Berriman J; Smith M J; Jakes R; Crowther R A
From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1406):213-27.
2001: Lee V M; Goedert M; Trojanowski J Q
Neurodegenerative tauopathies.
Annual review of neuroscience 2001;24():1121-59.
2001: Goedert M; Spillantini M G
Tau gene mutations and neurodegeneration.
Biochemical Society symposium 2001;(67):59-71.
2001: Götz J; Tolnay M; Barmettler R; Ferrari A; Bürki K; Goedert M; Probst A; Nitsch R M
Human tau transgenic mice. Towards an animal model for neuro- and glialfibrillary lesion formation.
Advances in experimental medicine and biology 2001;487():71-83.
2001: Spillantini M G; Goedert M
Tau gene mutations and tau pathology in frontotemporal dementia and parkinsonism linked to chromosome 17.
Advances in experimental medicine and biology 2001;487():21-37.
2000: Spillantini M G; Yoshida H; Rizzini C; Lantos P L; Khan N; Rossor M N; Goedert M; Brown J
A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies.
Annals of neurology 2000;48(6):939-43.
2000: Rizzini C; Goedert M; Hodges J R; Smith M J; Jakes R; Hills R; Xuereb J H; Crowther R A; Spillantini M G
Tau gene mutation K257T causes a tauopathy similar to Pick's disease.
Journal of neuropathology and experimental neurology 2000;59(11):990-1001.
2000: Smith M J; Crowther R A; Goedert M
The natural osmolyte trimethylamine N-oxide (TMAO) restores the ability of mutant tau to promote microtubule assembly.
FEBS letters 2000;484(3):265-70.
2000: Fleming Y; Armstrong C G; Morrice N; Paterson A; Goedert M; Cohen P
Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
The Biochemical journal 2000;352 Pt 1():145-54.
2000: Goedert M; Satumtira S; Jakes R; Smith M J; Kamibayashi C; White C L; Sontag E
Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations.
Journal of neurochemistry 2000;75(5):2155-62.
2000: Crowther R A; Daniel S E; Goedert M
Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain.
Neuroscience letters 2000;292(2):128-30.
2000: Goedert M; Spillantini M G
Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease.
Biochimica et biophysica acta 2000;1502(1):110-21.
2000: Crowther R A; Goedert M
Abnormal tau-containing filaments in neurodegenerative diseases.
Journal of structural biology 2000;130(2-3):271-9.
2000: Probst A; Götz J; Wiederhold K H; Tolnay M; Mistl C; Jaton A L; Hong M; Ishihara T; Lee V M; Trojanowski J Q; Jakes R; Crowther R A; Spillantini M G; Bürki K; Goedert M
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein.
Acta neuropathologica 2000;99(5):469-81.
2000: Spillantini M G; Goedert M
Tau mutations in familial frontotemporal dementia.
Brain : a journal of neurology 2000;123 ( Pt 5)():857-9.
2000: Duff K; Knight H; Refolo L M; Sanders S; Yu X; Picciano M; Malester B; Hutton M; Adamson J; Goedert M; Burki K; Davies P
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes.
Neurobiology of disease 2000;7(2):87-98.
2000: Serpell L C; Berriman J; Jakes R; Goedert M; Crowther R A
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4897-902.
2000: Yasuda M; Takamatsu J; D'Souza I; Crowther R A; Kawamata T; Hasegawa M; Hasegawa H; Spillantini M G; Tanimukai S; Poorkaj P; Varani L; Varani G; Iwatsubo T; Goedert M; Schellenberg D G; Tanaka C
A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)
Annals of neurology 2000;47(4):422-9.
2000: Spillantini M G; Van Swieten J C; Goedert M
Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).
Neurogenetics 2000;2(4):193-205.
2000: Giasson B I; Jakes R; Goedert M; Duda J E; Leight S; Trojanowski J Q; Lee V M
A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.
Journal of neuroscience research 2000;59(4):528-33.
2000: Varani L; Spillantini M G; Goedert M; Varani G
Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.
Nucleic acids research 2000;28(3):710-9.
2000: Goedert M; Ghetti B; Spillantini M G
Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process.
Annals of the New York Academy of Sciences 2000;920():74-83.
2000: Ghetti B; Murrell J R; Zolo P; Spillantini M G; Goedert M
Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome.
Annals of the New York Academy of Sciences 2000;920():52-62.
2000: Spillantini M G; Goedert M
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.
Annals of the New York Academy of Sciences 2000;920():16-27.
2000: Götz J; Barmettler R; Ferrari A; Goedert M; Probst A; Nitsch R M
In vivo analysis of wild-type and FTDP-17 tau transgenic mice.
Annals of the New York Academy of Sciences 2000;920():126-33.
1999: Murrell J R; Spillantini M G; Zolo P; Guazzelli M; Smith M J; Hasegawa M; Redi F; Crowther R A; Pietrini P; Ghetti B; Goedert M
Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits.
Journal of neuropathology and experimental neurology 1999;58(12):1207-26.
1999: Goedert M; Klug A
Tau protein and the paired helical filament of Alzheimer's disease.
Brain research bulletin 1999;50(5-6):469-70.
1999: Craxton M; Goedert M
Alternative splicing of synaptotagmins involving transmembrane exon skipping.
FEBS letters 1999;460(3):417-22.
1999: Börsch-Haubold A G; Ghomashchi F; Pasquet S; Goedert M; Cohen P; Gelb M H; Watson S P
Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways.
European journal of biochemistry / FEBS 1999;265(1):195-203.
1999: Thomas G M; Frame S; Goedert M; Nathke I; Polakis P; Cohen P
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.
FEBS letters 1999;458(2):247-51.
1999: Hall-Jackson C A; Eyers P A; Cohen P; Goedert M; Boyle F T; Hewitt N; Plant H; Hedge P
Paradoxical activation of Raf by a novel Raf inhibitor.
Chemistry & biology 1999;6(8):559-68.
1999: Jakes R; Crowther R A; Lee V M; Trojanowski J Q; Iwatsubo T; Goedert M
Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein.
Neuroscience letters 1999;269(1):13-6.
1999: Varani L; Hasegawa M; Spillantini M G; Smith M J; Murrell J R; Ghetti B; Klug A; Goedert M; Varani G
Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8229-34.
1999: Goedert M
Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):1101-18.
1999: Goedert M
Alzheimer's disease. Pinning down phosphorylated tau.
Nature 1999;399(6738):739-40.
1999: Spillantini M G; Tolnay M; Love S; Goedert M
Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia.
Acta neuropathologica 1999;97(6):585-94.
1999: Bugiani O; Murrell J R; Giaccone G; Hasegawa M; Ghigo G; Tabaton M; Morbin M; Primavera A; Carella F; Solaro C; Grisoli M; Savoiardo M; Spillantini M G; Tagliavini F; Goedert M; Ghetti B
Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau.
Journal of neuropathology and experimental neurology 1999;58(6):667-77.
1999: Eyers P A; van den IJssel P; Quinlan R A; Goedert M; Cohen P
Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.
FEBS letters 1999;451(2):191-6.
1999: Goedert M; Jakes R; Crowther R A
Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments.
FEBS letters 1999;450(3):306-11.
1999: Mirra S S; Murrell J R; Gearing M; Spillantini M G; Goedert M; Crowther R A; Levey A I; Jones R; Green J; Shoffner J M; Wainer B H; Schmidt M L; Trojanowski J Q; Ghetti B
Tau pathology in a family with dementia and a P301L mutation in tau.
Journal of neuropathology and experimental neurology 1999;58(4):335-45.
1999: Hasegawa M; Cuenda A; Spillantini M G; Thomas G M; Buée-Scherrer V; Cohen P; Goedert M
Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.
The Journal of biological chemistry 1999;274(18):12626-31.
1999: Goedert M; Spillantini M G; Crowther R A; Chen S G; Parchi P; Tabaton M; Lanska D J; Markesbery W R; Wilhelmsen K C; Dickson D W; Petersen R B; Gambetti P
Tau gene mutation in familial progressive subcortical gliosis.
Nature medicine 1999;5(4):454-7.
1999: Hall-Jackson C A; Goedert M; Hedge P; Cohen P
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo.
Oncogene 1999;18(12):2047-54.
1999: Rizzu P; Van Swieten J C; Joosse M; Hasegawa M; Stevens M; Tibben A; Niermeijer M F; Hillebrand M; Ravid R; Oostra B A; Goedert M; van Duijn C M; Heutink P
High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands.
American journal of human genetics 1999;64(2):414-21.
1999: Hasegawa M; Smith M J; Iijima M; Tabira T; Goedert M
FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10.
FEBS letters 1999;443(2):93-6.
1999: Goedert M; Hasegawa M
The tauopathies: toward an experimental animal model.
The American journal of pathology 1999;154(1):1-6.
1998: Lawler S; Fleming Y; Goedert M; Cohen P
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro.
Current biology : CB 1998;8(25):1387-90.
1998: Goedert M; Spillantini M G
Lewy body diseases and multiple system atrophy as alpha-synucleinopathies.
Molecular psychiatry 1998;3(6):462-5.
1998: Goedert M; Crowther R A; Spillantini M G
Tau mutations cause frontotemporal dementias.
Neuron 1998;21(5):955-8.
1998: Trojanowski J Q; Goedert M; Iwatsubo T; Lee V M
Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.
Cell death and differentiation 1998;5(10):832-7.
1998: Hasegawa M; Smith M J; Goedert M
Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly.
FEBS letters 1998;437(3):207-10.
1998: Goedert M; Spillantini M G; Davies S W
Filamentous nerve cell inclusions in neurodegenerative diseases.
Current opinion in neurobiology 1998;8(5):619-32.
1998: Crowther R A; Jakes R; Spillantini M G; Goedert M
Synthetic filaments assembled from C-terminally truncated alpha-synuclein.
FEBS letters 1998;436(3):309-12.
1998: Spillantini M G; Goedert M
Tau protein pathology in neurodegenerative diseases.
Trends in neurosciences 1998;21(10):428-33.
1998: Jensen P H; Nielsen M S; Jakes R; Dotti C G; Goedert M
Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.
The Journal of biological chemistry 1998;273(41):26292-4.
1998: Goedert M; Jakes R; Crowther R A; Hasegawa M; Smith M J; Spillantini M G
Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases.
Biochemical Society transactions 1998;26(3):463-71.
1998: Spillantini M G; Crowther R A; Jakes R; Cairns N J; Lantos P L; Goedert M
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.
Neuroscience letters 1998;251(3):205-8.
1998: Cohen P; Goedert M
Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid.
Chemistry & biology 1998;5(7):R161-4.
1998: Eyers P A; Craxton M; Morrice N; Cohen P; Goedert M
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution.
Chemistry & biology 1998;5(6):321-8.
1998: Spillantini M G; Murrell J R; Goedert M; Farlow M R; Klug A; Ghetti B
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7737-41.
1998: Spillantini M G; Crowther R A; Jakes R; Hasegawa M; Goedert M
alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6469-73.
1998: Qi Z; Zhu X; Goedert M; Fujita D J; Wang J H
Effect of heparin on phosphorylation site specificity of neuronal Cdc2-like kinase.
FEBS letters 1998;423(2):227-30.
1998: Goedert M
Neurofibrillary pathology of Alzheimer's disease and other tauopathies.
Progress in brain research 1998;117():287-306.
1997: Hasegawa M; Crowther R A; Jakes R; Goedert M
Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation.
The Journal of biological chemistry 1997;272(52):33118-24.
1997: Cuenda A; Goedert M; Craxton M; Jakes R; Cohen P
Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6).
Biochemical Society transactions 1997;25(4):S569.
1997: Murrell J R; Koller D; Foroud T; Goedert M; Spillantini M G; Edenberg H J; Farlow M R; Ghetti B
Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17.
American journal of human genetics 1997;61(5):1131-8.
1997: Lawler S; Cuenda A; Goedert M; Cohen P
SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK).
FEBS letters 1997;414(1):153-8.
1997: Spillantini M G; Schmidt M L; Lee V M; Trojanowski J Q; Jakes R; Goedert M
Alpha-synuclein in Lewy bodies.
Nature 1997;388(6645):839-40.
1997: Sergeant N; David J P; Goedert M; Jakes R; Vermersch P; Buée L; Lefranc D; Wattez A; Delacourte A
Two-dimensional characterization of paired helical filament-tau from Alzheimer's disease: demonstration of an additional 74-kDa component and age-related biochemical modifications.
Journal of neurochemistry 1997;69(2):834-44.
1997: Goedert M
Familial Parkinson's disease. The awakening of alpha-synuclein.
Nature 1997;388(6639):232-3.
1997: Goedert M; Cuenda A; Craxton M; Jakes R; Cohen P
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
The EMBO journal 1997;16(12):3563-71.
1997: Goedert M; Hasegawa M; Jakes R; Lawler S; Cuenda A; Cohen P
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
FEBS letters 1997;409(1):57-62.
1997: Chevallier N; Jiracek J; Vincent B; Baur C P; Spillantini M G; Goedert M; Dive V; Checler F
Examination of the role of endopeptidase 3.4.24.15 in A beta secretion by human transfected cells.
British journal of pharmacology 1997;121(3):556-62.
1997: Craxton M; Olsen A; Goedert M
Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location.
Genomics 1997;42(1):165-9.
1997: Goedert M; Hasegawa J; Craxton M; Leversha M A; Clegg S
Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization.
Genomics 1997;41(3):501-2.
1997: Tolnay M; Spillantini M G; Goedert M; Ulrich J; Langui D; Probst A
Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons.
Acta neuropathologica 1997;93(5):477-84.
1997: Spillantini M G; Goedert M; Crowther R A; Murrell J R; Farlow M R; Ghetti B
Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):4113-8.
1997: Chevallier N; Vizzavona J; Marambaud P; Baur C P; Spillantini M; Fulcrand P; Martinez J; Goedert M; Vincent J P; Checler F
Cathepsin D displays in vitro beta-secretase-like specificity.
Brain research 1997;750(1-2):11-9.
1997: Cuenda A; Cohen P; Buée-Scherrer V; Goedert M
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38).
The EMBO journal 1997;16(2):295-305.
1996: Probst A; Tolnay M; Langui D; Goedert M; Spillantini M G
Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment.
Acta neuropathologica 1996;92(6):588-96.
1996: Goedert M; Baur C P; Ahringer J; Jakes R; Hasegawa M; Spillantini M G; Smith M J; Hill F
PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans.
Journal of cell science 1996;109 ( Pt 11)():2661-72.
1996: Goedert M; Jakes R; Spillantini M G; Hasegawa M; Smith M J; Crowther R A
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.
Nature 1996;383(6600):550-3.
1996: Spillantini M G; Crowther R A; Goedert M
Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles.
Acta neuropathologica 1996;92(1):42-8.
1996: Buée-Scherrer V; Condamines O; Mourton-Gilles C; Jakes R; Goedert M; Pau B; Delacourte A
AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease.
Brain research. Molecular brain research 1996;39(1-2):79-88.
1996: Litersky J M; Johnson G V; Jakes R; Goedert M; Lee M; Seubert P
Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.
The Biochemical journal 1996;316 ( Pt 2)():655-60.
1996: Mertens S; Craxton M; Goedert M
SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases.
FEBS letters 1996;383(3):273-6.
1996: Hasegawa M; Jakes R; Crowther R A; Lee V M; Ihara Y; Goedert M
Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.
FEBS letters 1996;384(1):25-30.
1996: Andrä K; Abramowski D; Duke M; Probst A; Wiederhold K H; Bürki K; Goedert M; Sommer B; Staufenbiel M
Expression of APP in transgenic mice: a comparison of neuron-specific promoters.
Neurobiology of aging 1996;17(2):183-90.
1996: Goedert M; Marsh S; Carter N
Localization of the human kinesin light chain gene (KNS2) to chromosome 14q32.3 by fluorescence in situ hybridization.
Genomics 1996;32(1):173-5.
1996: Roses A D; Einstein G; Gilbert J; Goedert M; Han S H; Huang D; Hulette C; Masliah E; Pericak-Vance M A; Saunders A M; Schmechel D E; Strittmatter W J; Weisgraber K H; Xi P T
Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism.
Annals of the New York Academy of Sciences 1996;777():146-57.
1996: Goedert M
Tau protein and the neurofibrillary pathology of Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;777():121-31.
1996: Ghetti B; Piccardo P; Spillantini M G; Ichimiya Y; Porro M; Perini F; Kitamoto T; Tateishi J; Seiler C; Frangione B; Bugiani O; Giaccone G; Prelli F; Goedert M; Dlouhy S R; Tagliavini F
Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):744-8.
1996: Goedert M; Spillantini M G; Hasegawa M; Jakes R; Crowther R A; Klug A
Molecular dissection of the neurofibrillary lesions of Alzheimer's disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():565-73.
1995: Goedert M; Jakes R; Qi Z; Wang J H; Cohen P
Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase.
Journal of neurochemistry 1995;65(6):2804-7.
1995: Sperber B R; Leight S; Goedert M; Lee V M
Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells.
Neuroscience letters 1995;197(2):149-53.
1995: Seubert P; Mawal-Dewan M; Barbour R; Jakes R; Goedert M; Johnson G V; Litersky J M; Schenk D; Lieberburg I; Trojanowski J Q
Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.
The Journal of biological chemistry 1995;270(32):18917-22.
1995: Huang D Y; Weisgraber K H; Goedert M; Saunders A M; Roses A D; Strittmatter W J
ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.
Neuroscience letters 1995;192(3):209-12.
1995: Goedert M; Spillantini M G; Jakes R; Crowther R A; Vanmechelen E; Probst A; Götz J; Bürki K; Cohen P
Molecular dissection of the paired helical filament.
Neurobiology of aging 1995;16(3):325-34.
1995: Spillantini M G; Divane A; Goedert M
Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35.
Genomics 1995;27(2):379-81.
1995: Götz J; Probst A; Spillantini M G; Schäfer T; Jakes R; Bürki K; Goedert M
Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.
The EMBO journal 1995;14(7):1304-13.
1995: Goedert M; Jakes R; Vanmechelen E
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.
Neuroscience letters 1995;189(3):167-9.
1995: Goedert M
Molecular dissection of the neurofibrillary lesions of Alzheimer's disease.
Arzneimittel-Forschung 1995;45(3A):403-9.
1995: Craxton M; Goedert M
Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain.
FEBS letters 1995;361(2-3):196-200.
1995: Goedert M; Jakes R; Spillantini M G; Crowther R A; Cohen P; Vanmechelen E; Probst A; Götz J; Bürki K
Tau protein in Alzheimer's disease.
Biochemical Society transactions 1995;23(1):80-5.
1995: Jakes R; Harrington C R; Spillantini M G; Goedert M; Klug A
Characterisation of an antibody relevant to the neuropathology of Alzheimer disease.
Alzheimer disease and associated disorders 1995;9(1):47-51.
1994: Otvos L; Feiner L; Lang E; Szendrei G I; Goedert M; Lee V M
Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.
Journal of neuroscience research 1994;39(6):669-73.
1994: Strittmatter W J; Saunders A M; Goedert M; Weisgraber K H; Dong L M; Jakes R; Huang D Y; Pericak-Vance M; Schmechel D; Roses A D
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11183-6.
1994: Goedert M; Strittmatter W J; Roses A D
Alzheimer's disease. Risky apolipoprotein in brain.
Nature 1994;372(6501):45-6.
1994: Huang D Y; Goedert M; Jakes R; Weisgraber K H; Garner C C; Saunders A M; Pericak-Vance M A; Schmechel D E; Roses A D; Strittmatter W J
Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.
Neuroscience letters 1994;182(1):55-8.
1994: Fawcett J W; Mathews G; Housden E; Goedert M; Matus A
Regenerating sciatic nerve axons contain the adult rather than the embryonic pattern of microtubule associated proteins.
Neuroscience 1994;61(4):789-804.
1994: Goedert M; Jakes R; Crowther R A; Cohen P; Vanmechelen E; Vandermeeren M; Cras P
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein.
The Biochemical journal 1994;301 ( Pt 3)():871-7.
1994: Jakes R; Spillantini M G; Goedert M
Identification of two distinct synucleins from human brain.
FEBS letters 1994;345(1):27-32.
1994: Strittmatter W J; Weisgraber K H; Goedert M; Saunders A M; Huang D; Corder E H; Dong L M; Jakes R; Alberts M J; Gilbert J R
Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype.
Experimental neurology 1994;125(2):163-71; discussion 172-4.
1994: Crowther R A; Olesen O F; Smith M J; Jakes R; Goedert M
Assembly of Alzheimer-like filaments from full-length tau protein.
FEBS letters 1994;337(2):135-8.
1993: Lo M M; Fieles A W; Norris T E; Dargis P G; Caputo C B; Scott C W; Lee V M; Goedert M
Human tau isoforms confer distinct morphological and functional properties to stably transfected fibroblasts.
Brain research. Molecular brain research 1993;20(3):209-20.
1993: Goedert M
Tau protein and the neurofibrillary pathology of Alzheimer's disease.
Trends in neurosciences 1993;16(11):460-5.
1993: Robertson J; Loviny T L; Goedert M; Jakes R; Murray K J; Anderton B H; Hanger D P
Phosphorylation of tau by cyclic-AMP-dependent protein kinase.
Dementia (Basel, Switzerland) 1993;4(5):256-63.
1993: Goedert M; Jakes R; Crowther R A; Six J; Lübke U; Vandermeeren M; Cras P; Trojanowski J Q; Lee V M
The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5066-70.
1993: Bramblett G T; Goedert M; Jakes R; Merrick S E; Trojanowski J Q; Lee V M
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
Neuron 1993;10(6):1089-99.
1993: Lee J H; Goedert M; Hill W D; Lee V M; Trojanowski J Q
Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord.
Experimental neurology 1993;121(1):93-105.
1992: Goedert M; Cohen E S; Jakes R; Cohen P
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]
FEBS letters 1992;312(1):95-9.
1992: Potier M C; Kuo W L; Dutriaux A; Gray J; Goedert M
Construction and characterization of a yeast artificial chromosome library containing 1.5 equivalents of human chromosome 21.
Genomics 1992;14(2):481-3.
1992: Crowther R A; Olesen O F; Jakes R; Goedert M
The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease.
FEBS letters 1992;309(2):199-202.
1992: Gustke N; Steiner B; Mandelkow E M; Biernat J; Meyer H E; Goedert M; Mandelkow E
The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.
FEBS letters 1992;307(2):199-205.
1992: Biernat J; Mandelkow E M; Schröter C; Lichtenberg-Kraag B; Steiner B; Berling B; Meyer H; Mercken M; Vandermeeren A; Goedert M
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.
The EMBO journal 1992;11(4):1593-7.
1992: Goedert M; Spillantini M G; Crowther R A
Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1983-7.
1992: Goedert M; Spillantini M G; Cairns N J; Crowther R A
Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms.
Neuron 1992;8(1):159-68.
1991: Goedert M; Sisodia S S; Price D L
Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease.
Current opinion in neurobiology 1991;1(3):441-7.
1991: Dingus J; Obar R A; Hyams J S; Goedert M; Vallee R B
Use of a heat-stable microtubule-associated protein class-specific antibody to investigate the mechanism of microtubule binding.
The Journal of biological chemistry 1991;266(28):18854-60.
1991: Goedert M; Spillantini M G; Crowther R A
Tau proteins and neurofibrillary degeneration.
Brain pathology (Zurich, Switzerland) 1991;1(4):279-86.
1991: Goedert M; Spillantini M G; Jakes R
Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau.
Neuroscience letters 1991;126(2):149-54.
1991: Goedert M; Crowther R A; Garner C C
Molecular characterization of microtubule-associated proteins tau and MAP2.
Trends in neurosciences 1991;14(5):193-9.
1991: Wright A F; Goedert M; Hastie N D
Familial Alzheimer's disease. Beta amyloid resurrected.
Nature 1991;349(6311):653-4.
1990: Goedert M; Jakes R
Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.
The EMBO journal 1990;9(13):4225-30.
1990: Kindler S; Schulz B; Goedert M; Garner C C
Molecular structure of microtubule-associated protein 2b and 2c from rat brain.
The Journal of biological chemistry 1990;265(32):19679-84.
1990: Spillantini M G; Goedert M; Jakes R; Klug A
Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3947-51.
1990: Spillantini M G; Goedert M; Jakes R; Klug A
Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3952-6.
1990: Goedert M; Spillantini M G
Molecular neuropathology of Alzheimer's disease: in situ hybridization studies.
Cellular and molecular neurobiology 1990;10(1):159-74.
1990: Hanley M R; Cheung W T; Hawkins P; Poyner D; Benton H P; Blair L; Jackson T R; Goedert M
The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action.
Ciba Foundation symposium 1990;150():23-38; discussion 38-46.
1989: Spillantini M G; Aloe L; Alleva E; De Simone R; Goedert M; Levi-Montalcini R
Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8555-9.
1989: Allen S J; Dawbarn D; Spillantini M G; Goedert M; Wilcock G K; Moss T H; Semenenko F M
Distribution of beta-nerve growth factor receptors in the human basal forebrain.
The Journal of comparative neurology 1989;289(4):626-40.
1989: Spillantini M G; Hunt S P; Ulrich J; Goedert M
Expression and cellular localization of amyloid beta-protein precursor transcripts in normal human brain and in Alzheimer's disease.
Brain research. Molecular brain research 1989;6(2-3):143-50.
1989: Goedert M; Spillantini M G; Jakes R; Rutherford D; Crowther R A
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease.
Neuron 1989;3(4):519-26.
1989: Goedert M; Crowther R A
Amyloid plaques, neurofibrillary tangles and their relevance for the study of Alzheimer's disease.
Neurobiology of aging 1989;10(5):405-6; discussion 412-4.
1989: Goedert M; Spillantini M G; Potier M C; Ulrich J; Crowther R A
Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.
The EMBO journal 1989;8(2):393-9.
1989: Goedert M; Fine A; Dawbarn D; Wilcock G K; Chao M V
Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease.
Brain research. Molecular brain research 1989;5(1):1-7.
1989: Goedert M
Radioligand-binding assays for study of neurotensin receptors.
Methods in enzymology 1989;168():462-81.
1989: Crowther T; Goedert M; Wischik C M
The repeat region of microtubule-associated protein tau forms part of the core of the paired helical filament of Alzheimer's disease.
Annals of medicine 1989;21(2):127-32.
1988: Jackson T R; Blair L A; Marshall J; Goedert M; Hanley M R
The mas oncogene encodes an angiotensin receptor.
Nature 1988;335(6189):437-40.
1988: Goedert M; Wischik C M; Crowther R A; Walker J E; Klug A
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):4051-5.
1987: Goedert M
Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.
The EMBO journal 1987;6(12):3627-32.
1987: Goedert M; Hunt S P
The cellular localization of preprotachykinin A messenger RNA in the bovine nervous system.
Neuroscience 1987;22(3):983-92.
1987: Hunt S P; Goedert M
The cellular localization of mRNA in neurobiology.
Biochemical Society transactions 1987;15(1):133.
1986: Goedert M
Molecular cloning of the chicken nerve growth factor gene: mRNA distribution in developing and adult tissues.
Biochemical and biophysical research communications 1986;141(3):1116-22.
1986: Goedert M; Fine A; Hunt S P; Ullrich A
Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease.
Brain research 1986;387(1):85-92.
1985: Goedert M; Lightman S L; Mantyh P W; Hunt S P; Emson P C
Neurotensin-like immunoreactivity and neurotensin receptors in the rat hypothalamus and in the neurointermediate lobe of the pituitary gland.
Brain research 1985;358(1-2):59-69.
1985: Emson P C; Horsfield P M; Goedert M; Rossor M N; Hawkes C H
Neurotensin in human brain: regional distribution and effects of neurological illness.
Brain research 1985;347(2):239-44.
1985: Goedert M; Schwartz W N; Williams B J
The comparative distribution of [Lys8-Asn9]-neurotensin8-13-like immunoreactivity in chicken and rat tissues.
Brain research 1985;342(2):259-65.
1985: Goedert M; Iversen S D; Emson P C
The effects of chronic neuroleptic treatment on neurotensin-like immunoreactivity in the rat central nervous system.
Brain research 1985;335(2):334-6.
1985: Goedert M; Hunt S P; Mantyh P W; Emson P C
The ontogenetic development of neurotensin-like immunoreactivity and neurotensin receptors in the cat striatum.
Brain research 1985;352(1):127-31.
1985: Fitzgerald M; Wall P D; Goedert M; Emson P C
Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section.
Brain research 1985;332(1):131-41.
1985: Hunter J C; Goedert M; Pinnock R D
Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices.
Biochemical and biophysical research communications 1985;127(2):616-22.
1985: Reeve J G; Goedert M; Emson P C; Bleehen N M
Neurotensin in human small cell lung carcinoma.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1985;99():175-6.
1984: Goedert M; Pinnock R D; Downes C P; Mantyh P W; Emson P C
Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices.
Brain research 1984;323(1):193-7.
1984: Bannon M J; Goedert M; Williams B
The possible relation of glutathione, melanin and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) to Parkinson's disease.
Biochemical pharmacology 1984;33(17):2697-8.
1984: Goedert M; Hunter J C; Ninkovic M
Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum.
Nature 1984;311(5981):59-62.
1984: Goedert M; Sturmey N; Williams B J; Emson P C
The comparative distribution of xenopsin- and neurotensin-like immunoreactivity in Xenopus laevis and rat tissues.
Brain research 1984;308(2):273-80.
1984: Goedert M; Reeve J G; Emson P C; Bleehen N M
Neurotensin in human small cell lung carcinoma.
British journal of cancer 1984;50(2):179-83.
1984: Goedert M; Pittaway K; Williams B J; Emson P C
Specific binding of tritiated neurotensin to rat brain membranes: characterization and regional distribution.
Brain research 1984;304(1):71-81.
1984: Mantyh P W; Pinnock R D; Downes C P; Goedert M; Hunt S P
Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS.
Nature 1984;309(5971):795-7.
1984: Goedert M; Lightman S L; Emson P C
Neurotensin in the rat anterior pituitary gland: effects of endocrinological manipulations.
Brain research 1984;299(1):160-3.
1984: Goedert M; Mantyh P W; Hunt S P; Emson P C
Localization of specific neurotensin binding sites in the rat adrenal gland.
Brain research 1984;299(2):389-92.
1984: Goedert M; Pittaway K; Emson P C
Neurotensin receptors in the rat striatum: lesion studies.
Brain research 1984;299(1):164-8.
1984: Marley P D; Lightman S L; Forsling M L; Todd K; Goedert M; Rehfeld J F; Emson P C
Localization and actions of cholecystokinin in the rat pituitary neurointermediate lobe.
Endocrinology 1984;114(5):1902-11.
1984: Bannon M J; Goedert M
Changes in substance P concentrations after protein synthesis inhibition provide an index of substance P utilization.
Brain research 1984;301(1):184-6.
1984: Mantyh P W; Goedert M; Hunt S P
Autoradiographic visualization of receptor binding sites for substance P in the gastrointestinal tract of the guinea pig.
European journal of pharmacology 1984;100(1):133-4.
1984: Goedert M; Otten U; Hunt S P; Bond A; Chapman D; Schlumpf M; Lichtensteiger W
Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(5):1580-4.
1984: Goedert M; Mantyh P W; Emson P C; Hunt S P
Inverse relationship between neurotensin receptors and neurotensin-like immunoreactivity in cat striatum.
Nature 1984;307(5951):543-6.
1983: Bannon M J; Elliott P J; Alpert J E; Goedert M; Iversen S D; Iversen L L
Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones.
Nature 1983;306(5945):791-2.
1983: Goedert M; Mantyh P W; Hunt S P; Emson P C
Mosaic distribution of neurotensin-like immunoreactivity in the cat striatum.
Brain research 1983;274(1):176-9.
1983: Goedert M; Emson P C
The regional distribution of neurotensin-like immunoreactivity in central and peripheral tissues of the cat.
Brain research 1983;272(2):291-7.
1983: Goedert M; Reynolds G P; Emson P C
Neurotensin in the adrenal medulla.
Neuroscience letters 1983;35(2):155-60.
1983: Nagy J I; Iversen L L; Goedert M; Chapman D; Hunt S P
Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1983;3(2):399-406.
1982: Goedert M; Nagy J I; Emson P C
The origin of substance P in the rat submandibular gland and its major duct.
Brain research 1982;252(2):327-33.
1982: Goedert M; Lightman S L; Nagy J I; Marley P D; Emson P C
Neurotensin in the rat anterior pituitary gland.
Nature 1982;298(5870):163-5.
1982: Emson P C; Goedert M; Horsfield P; Rioux F; St Pierre S
The regional distribution and chromatographic characterisation of neurotensin-like immunoreactivity in the rat central nervous system.
Journal of neurochemistry 1982;38(4):992-9.
1982: Mayer N; Lembeck F; Goedert M; Otten U
Effects of antibodies against nerve growth factor on the postnatal development of substance P-containing sensory neurons.
Neuroscience letters 1982;29(1):47-52.
1982: Emson P C; Goedert M; Williams B; Ninkovic M; Hunt S P
Neurotensin: regional distribution, characterization, and inactivation.
Annals of the New York Academy of Sciences 1982;400():198-215.
1982: Emson P C; Goedert M; Benton H; St-Pierre S; Rioux F
The regional distribution and chromatographic characterization of neurotensin-like immunoreactivity in the rat.
Advances in biochemical psychopharmacology 1982;33():477-85.
1982: Nagy J I; Goedert M; Hunt S P; Bond A
The nature of the substance P-containing nerve fibres in taste papillae of the rat tongue.
Neuroscience 1982;7(12):3137-51.
1981: Goedert M; Stoeckel K; Otten U
Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5895-8.
1981: Otten U; Goedert M; Baumann J B; Girard J
Stimulation of the pituitary-adrenocortical axis and induction of tyrosine hydroxylase by nerve growth factor are not dependent on mouse submaxillary gland isorenin.
Brain research 1981;217(1):207-11.
1981: Goedert M; Otten U; Metz H
Endogenous opioid peptides.
Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg 1981;118(1):7-17.
1980: Goedert M; Otten U; Schäfer T; Schwab M; Thoenen H
Immunosympathectomy: lack of evidence for a complement-mediated cytotoxic mechanism.
Brain research 1980;201(2):399-409.
1980: Otten U; Goedert M; Mayer N; Lembeck F
Requirement of nerve growth factor for development of substance P-containing sensory neurones.
Nature 1980;287(5778):158-9.
1980: Goedert M; Otten U; Suda K; Heitz P U; Stalder G A; Obrecht J P; Holzach P; Allgöwer M
Dopamine, norepinephrine and serotonin production by an intestinal carcinoid tumor.
Cancer 1980;45(1):104-7.
1979: Otten U; Goedert M; Schwab M; Thibault J
Immunization of adult rats against 2.5 S NGF: effects on the peripheral sympathetic nervous system.
Brain research 1979;176(1):79-90.
1978: Goedert M; Otten U; Thoenen H
Biochemical effects of antibodies against nerve growth factor on developing and differentiated sympathetic ganglia.
Brain research 1978;148(1):264-8.
1978: Goedert M; Otten U; Thoenen H
Biochemical effects of nerve growth factor and its antibody on the vas defferens and the adrenal medulla.
Neuroscience letters 1978;8(1):71-6.
1978: Goedert M
Nerve growth factor: its growing importance for neurobiology and medicine.
Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg 1978;115(2):69-74.
1977: Goedert M; Bühler F R
Nerve-growth-factor antibodies in idiopathic orthostatic hypotension?
The New England journal of medicine 1977;297(6):336-7.
1975: Goedert M; Achaeffer F; Neuberg P
Letter: White cells and uric acid in alcoholism.
Lancet 1975;1(7897):52.

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