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Ajay Goel

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Alexander Link; Juan Jose Lozano; Yan Shen; Francesc Balaguer; C Richard Boland; Hon-Chiu E Leung; Ajay Goel
Curcumin modulates DNA methylation in colorectal cancer cells.
Ajay Goel; C Richard Boland
Epigenetics of colorectal cancer.
Masanobu Takahashi; Bharat B Aggarwal; C Richard Boland; Keun Hur; Alexander Link; Yan Shen; Bokyung Sung; Ajay Goel
Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.

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All Publications

2013: Alexander Link; Juan Jose Lozano; Yan Shen; Francesc Balaguer; C Richard Boland; Hon-Chiu E Leung; Ajay Goel
Curcumin modulates DNA methylation in colorectal cancer cells.
PloS one 2013;8(2):e57709.
2012: Ajay Goel; C Richard Boland
Epigenetics of colorectal cancer.
Gastroenterology 2012;143(6):1442-1460.e1.
2012: Masanobu Takahashi; Bharat B Aggarwal; C Richard Boland; Keun Hur; Alexander Link; Yan Shen; Bokyung Sung; Ajay Goel
Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.
Carcinogenesis 2012;33(12):2441-9.
2012: Jacqueline A Gasche; Ajay Goel
Epigenetic mechanisms in oral carcinogenesis.
Future oncology (London, England) 2012;8(11):1407-25.
2012: Melissa Garcia; Ajay Goel; Hyeong Rok Kim; C Richard Boland; Chan Choi; Yahya Daoud; Masanobu Takahashi; Yuji Toiyama; M Koi
Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability.
Gastroenterology 2012;143(1):48-50.e1.
2012: Masanobu Takahashi; Yuji Toiyama; Keun Hur; Francesc Balaguer; C Richard Boland; Antoni Castells; Miriam Cuatrecasas; Ajay Goel
The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer.
PloS one 2012;7(10):e46684.
2011: Francesc Balaguer; C Richard Boland; Antoni Castells; Miriam Cuatrecasas; Meritxell Gironella; Mildred Arnold; Rodrigo Jover; Alexander Link; Xavier Llor; Juan Jose Lozano; Meltzer Stephen J.; Leticia Moreira; Georgina Ramirez; Yan Shen; Elena Stoffel; Sapna Syngal; Ajay Goel
Colorectal cancers with microsatellite instability display unique miRNA profiles.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(19):6239-49.
2011: Jacqueline A Gasche; C Richard Boland; Jürgen Hoffmann; Ajay Goel
Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells.
International journal of cancer. Journal international du cancer 2011;129(5):1053-63.
2011: Yuriko Mori; Alexandru Olaru; Florin Selaru; Jian Yang; Wayne Yu; Rachana Agarwal; Steven R Brant; Yulan Cheng; Mark D Duncan; Ajay Goel; David F Hutcheon; Susan Hutfless; JOHN KWON; Mark Lazarev; Delgermaa Luvsanjav; Michael Marohn; Meltzer Stephen J.
Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning.
Endocrine-related cancer 2011;18(4):465-78.
2011: Rodrigo Jover; Thuy-Phuong Nguyen; Lucía Pérez-Carbonell; Pedro Zapater; Artemio Payá; Cristina Alenda; Estefanía Rojas; JOAQUIN cubiella; Francesc Balaguer; Juan D Morillas; Juan Clofent; Luis Bujanda; Josep M Reñé; Xavier Bessa; Rosa M Xicola; David Nicolás-Pérez; Antoni Castells; Montserrat Andreu; Xavier Llor; C Richard Boland; Ajay Goel
5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer.
Gastroenterology 2011;140(4):1174-81.
2011: Ajay Goel; Thuy-Phuong Nguyen; Hon-Chiu E Leung; Takeshi Nagasaka; Jennifer Rhees; Erin Hotchkiss; Mildred Arnold; Pia Banerji; M Koi; Chau-To Kwok; Deborah Packham; Lara Lipton; C Richard Boland; Robyn L Ward; Megan P Hitchins
De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one.
International journal of cancer. Journal international du cancer 2011;128(4):869-78.
2011: Ajay Goel
Somatostatin methylation as a biomarker for gastric cancer: ready for "prime time" or for further validation?
Digestive diseases and sciences 2011;56(1):1-3.
2010: Alexander Link; Francesc Balaguer; Ajay Goel
Cancer chemoprevention by dietary polyphenols: promising role for epigenetics.
Biochemical pharmacology 2010;80(12):1771-92.
2010: Ajay Goel; Takeshi Nagasaka; Jennifer Spiegel; Richard Meyer; Warren E Lichliter; C Richard Boland
Low frequency of Lynch syndrome among young patients with non-familial colorectal cancer.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2010;8(11):966-71.
2010: Francesc Balaguer; Alexander Link; Juan Jose Lozano; Miriam Cuatrecasas; Takeshi Nagasaka; C Richard Boland; Ajay Goel
Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis.
Cancer research 2010;70(16):6609-18.
2010: C Richard Boland; Ajay Goel
Clearing the air on smoking and colorectal cancer.
Journal of the National Cancer Institute 2010;102(14):996-7.
2010: Alexander Link; Francesc Balaguer; Yan Shen; Takeshi Nagasaka; Juan José Lozano; C Richard Boland; Ajay Goel
Fecal MicroRNAs as novel biomarkers for colon cancer screening.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010;19(7):1766-74.
2010: Ajay Goel; Rosa M Xicola; Thuy-Phuong Nguyen; Brian J Doyle; Vanessa R Sohn; Prathap Bandipalliam; Laura S Rozek; Josep Reyes; Carmen Cordero; Francesc Balaguer; Antoni Castells; Rodrigo Jover; Montserrat Andreu; Sapna Syngal; C Richard Boland; Xavier Llor
Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.
Gastroenterology 2010;138(5):1854-62.
2010: Takeshi Nagasaka; Jennifer Rhees; Matthias Kloor; Johannes Gebert; Yoshio Naomoto; C Richard Boland; Ajay Goel
Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers.
Cancer research 2010;70(8):3098-108.
2010: Ajay Goel
DNA methylation-based fecal biomarkers for the noninvasive screening of GI cancers.
Future oncology (London, England) 2010;6(3):333-6.
2010: Ajay Goel; Bharat B Aggarwal
Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.
Nutrition and cancer 2010;62(7):919-30.
2010: Ajay Goel; Takeshi Nagasaka; Richard Hamelin; C Richard Boland
An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers.
PloS one 2010;5(2):e9393.
2010: Ajay Goel; Clement Richard Boland
Recent insights into the pathogenesis of colorectal cancer.
Current opinion in gastroenterology 2010;26(1):47-52.
2009: Ajay Goel; A Mittal; R Evstatiev; M Nemeth; W Kruis; M Stolte; C Richard Boland; Christoph Gasche
In vivo effects of mesalazine or E. coli Nissle 1917 on microsatellite instability in ulcerative colitis.
Alimentary pharmacology & therapeutics 2009;30(6):634-42.
2009: Clement Richard Boland; Sung Kwan Shin; Ajay Goel
Promoter methylation in the genesis of gastrointestinal cancer.
Yonsei medical journal 2009;50(3):309-21.
2009: Alex Vilkin; Yaron Niv; Takeshi Nagasaka; Sarah Morgenstern; Zohar Levi; Zvi Fireman; Florentine Fuerst; Ajay Goel; C Richard Boland
Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel.
Cancer 2009;115(4):760-9.
2009: C Richard Boland; Natalia L Komarova; Ajay Goel
Chromosomal instability and cancer: not just one CINgle mechanism.
Gut 2009;58(2):163-4.
2009: Barbara Jung; Jessica Gomez; Eddy Chau; Jennifer Cabral; Jeffrey K Lee; Aimee Anselm; Przemyslaw Slowik; Deena Ream-Robinson; Karen Messer; Judith Sporn; Sung K Shin; C Richard Boland; Ajay Goel; John M Carethers
Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.
PloS one 2009;4(12):e8308.
2009: Alexander Link; Sung Kwan Shin; Takeshi Nagasaka; Francesc Balaguer; Minoru Koi; Barbara Jung; C Richard Boland; Ajay Goel
JC virus mediates invasion and migration in colorectal metastasis.
PloS one 2009;4(12):e8146.
2008: Michael Selgrad; Jan Jacob Koornstra; Lucia Fini; Marloes Blom; Rong Huang; Edward B Devol; Wytske Boersma-van Ek; Gerard Dijkstra; Robert C Verdonk; Steven de Jong; Ajay Goel; Sharenda L Williams; Richard L Meyer; Elizabeth B Haagsma; Luigi Ricciardiello; C Richard Boland
JC virus infection in colorectal neoplasia that develops after liver transplantation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6717-21.
2008: Astrid C Haugen; Ajay Goel; Kanae Yamada; Giancarlo Marra; Thuy-Phuong Nguyen; Takeshi Nagasaka; Shinsaku Kanazawa; Junichi Koike; Yoshinori Kikuchi; Xiaoling Zhong; Michitsune Arita; Kazutoshi Shibuya; Mitsuo Oshimura; Hiromichi Hemmi; C Richard Boland; Minoru Koi
Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer.
Cancer research 2008;68(20):8465-72.
2008: Christian N Arnold; Takeshi Nagasaka; Ajay Goel; Iris Scharf; Patricia Grabowski; Andrea Sosnowski; Annette Schmitt-Gräff; C Richard Boland; Rudolf Arnold; Hubert E Blum
Molecular characteristics and predictors of survival in patients with malignant neuroendocrine tumors.
International journal of cancer. Journal international du cancer 2008;123(7):1556-64.
2008: Ajay Goel; Sonia Jhurani; Bharat B Aggarwal
Multi-targeted therapy by curcumin: how spicy is it?
Molecular nutrition & food research 2008;52(9):1010-30.
2008: Michael Selgrad; C Richard Boland; Lucia Fini; Ajay Goel; Peter Malfertheiner; Luigi Ricciardiello
The role of viral and bacterial pathogens in gastrointestinal cancer.
Journal of cellular physiology 2008;216(2):378-88.
2008: Takeshi Nagasaka; Naoshi Nishida; Hiromi Sasamoto; Sung Kwan Shin; Noriaki Tanaka; Alex Vilkin; C Richard Boland; Johannes Gebert; Matthias Kloor; Minoru Koi; Nagahide Matsubara; Ajay Goel
Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer.
Gastroenterology 2008;134(7):1950-60, 1960.e1.
2008: Woon Tae Jung; Mei-Shu Li; Ajay Goel; C Richard Boland
JC virus T-antigen expression in sporadic adenomatous polyps of the colon.
Cancer 2008;112(5):1028-36.
2008: Naoshi Nishida; Takafumi Nishimura; C Richard Boland; Iwao Ikai; Takeshi Nagasaka; Ajay Goel
Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2008;47(3):908-18.
2008: Ajay Goel; Ajaikumar Kunnumakkara; Bharat B Aggarwal
Curcumin as "Curecumin": from kitchen to clinic.
Biochemical pharmacology 2008;75(4):787-809.
2007: Sung Kwan Shin; Takeshi Nagasaka; Barbara H Jung; Nagahide Matsubara; Won Ho Kim; John M Carethers; C Richard Boland; Ajay Goel
Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.
Gastroenterology 2007;133(6):1849-57.
2007: Naoshi Nishida; Takafumi Nishimura; Takeshi Nagasaka; Iwao Ikai; Ajay Goel; Goel Ajay; C Richard Boland
Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis.
Cancer research 2007;67(10):4586-94.
2007: Naoshi Nishida; Takeshi Nagasaka; Kazuhiro Kashiwagi; C Richard Boland; Ajay Goel
High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers.
Cancer biology & therapy 2007;6(4):525-33.
2007: Ajay Goel; Takeshi Nagasaka; Christian N Arnold; Toru Inoue; Cody Hamilton; Donna Niedzwiecki; Carolyn Corlies Compton; Robert J Mayer; Richard M Goldberg; Monica M Bertagnolli; C Richard Boland
The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.
Gastroenterology 2007;132(1):127-38.
2006: Sung Kwan Shin; Mei-Shu Li; Florentine Fuerst; Erin Hotchkiss; Richard Meyer; Il Tae Kim; Ajay Goel; C Richard Boland
Oncogenic T-antigen of JC virus is present frequently in human gastric cancers.
Cancer 2006;107(3):481-8.
2006: Ajay Goel; Mei-Shu Li; Takeshi Nagasaka; Sung Kwan Shin; Florentine Fuerst; Luigi Ricciardiello; Linda Wasserman; C Richard Boland
Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers.
Gastroenterology 2006;130(7):1950-61.
2006: Ajay Goel; Florentine Fuerst; Erin Hotchkiss; C Richard Boland
Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells.
Cancer biology & therapy 2006;5(5):529-35.
2005: C Richard Boland; Ajay Goel
Somatic evolution of cancer cells.
Seminars in cancer biology 2005;15(6):436-50.
2005: Christian N Arnold; Ajay Goel; Hubert E Blum; C Richard Boland
Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis.
Cancer 2005;104(10):2035-47.
2005: C Richard Boland; M G Luciani; Christoph Gasche; Ajay Goel
Infection, inflammation, and gastrointestinal cancer.
Gut 2005;54(9):1321-31.
2005: Ajay Goel; Christoph Gasche; C Richard Boland
Chemoprevention goes gourmet: different flavors of NO-aspirin.
Molecular interventions 2005;5(4):207-10.
2004: Ajay Goel; Christian N Arnold; Pierfrancesco Tassone; Dong K Chang; Donna Niedzwiecki; Jeannette M Dowell; Linda Wasserman; Carolyn Corlies Compton; Robert J Mayer; Monica M Bertagnolli; C Richard Boland
Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers.
International journal of cancer. Journal international du cancer 2004;112(5):754-9.
2004: Christian N Arnold; Ajay Goel; Donna Niedzwiecki; Jeannette M Dowell; Linda Wasserman; Carolyn Corlies Compton; Robert J Mayer; Monica M Bertagnolli; C Richard Boland
APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q.
Cancer biology & therapy 2004;3(10):960-4.
2004: Ajay Goel; Christian N Arnold; Donna Niedzwiecki; John M Carethers; Jeannette M Dowell; Linda Wasserman; Carolyn Corlies Compton; Robert J Mayer; Monica M Bertagnolli; C Richard Boland
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.
Cancer research 2004;64(9):3014-21.
2004: Christian N Arnold; Ajay Goel; Carolyn Corlies Compton; Victoria Marcus; Donna Niedzwiecki; Jeannette M Dowell; Linda Wasserman; Toru Inoue; Robert J Mayer; Monica M Bertagnolli; C Richard Boland
Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.
Cancer biology & therapy 2004;3(1):73-8.
2003: Christian N Arnold; Ajay Goel; C Richard Boland
Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines.
International journal of cancer. Journal international du cancer 2003;106(1):66-73.
2003: Dong K Chang; Ajay Goel; Luigi Ricciardiello; Dong Ho Lee; Christina L Chang; John M Carethers; C Richard Boland
Effect of H(2)O(2) on cell cycle and survival in DNA mismatch repair-deficient and -proficient cell lines.
Cancer letters 2003;195(2):243-51.
2003: Ajay Goel; Christian N Arnold; Donna Niedzwiecki; Dong K Chang; Luigi Ricciardiello; John M Carethers; Jeannette M Dowell; Linda Wasserman; Carolyn Corlies Compton; Robert J Mayer; Monica M Bertagnolli; C Richard Boland
Characterization of sporadic colon cancer by patterns of genomic instability.
Cancer research 2003;63(7):1608-14.
2003: Christoph Gasche; Christina L Chang; Loki Natarajan; Ajay Goel; Jennifer Rhees; Dennis J Young; Christian N Arnold; C Richard Boland
Identification of frame-shift intermediate mutant cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1914-9.
2003: Luigi Ricciardiello; Ajay Goel; Vilma Mantovani; Tania Fiorini; Stefania Fossi; Dong K Chang; Veronica Lunedei; Paolo Pozzato; Rocco Maurizio Zagari; Luca De Luca; Lorenzo Fuccio; Giuseppe N Martinelli; Enrico Roda; C Richard Boland; Franco Bazzoli
Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer.
Cancer research 2003;63(4):787-92.
2003: Ajay Goel; Dong K Chang; Luigi Ricciardiello; Christoph Gasche; C Richard Boland
A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):383-90.
2003: C Richard Boland; Ajay Goel
A rat virus visits the clinic: translating basic discoveries into clinical medicine in the 21st century.
Gut 2003;52(1):8-9.
2001: Ajay Goel; Christian N Arnold; C Richard Boland
Multistep progression of colorectal cancer in the setting of microsatellite instability: new details and novel insights.
Gastroenterology 2001;121(6):1497-502.
2001: Ajay Goel; C Richard Boland; Dharam P Chauhan
Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells.
Cancer letters 2001;172(2):111-8.
2001: Christoph Gasche; C L Chang; J Rhees; Ajay Goel; C Richard Boland
Oxidative stress increases frameshift mutations in human colorectal cancer cells.
Cancer research 2001;61(20):7444-8.
2001: Luigi Ricciardiello; Dong K Chang; Luigi Laghi; Ajay Goel; CL Chang; C Richard Boland
Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues.
Journal of virology 2001;75(4):1996-2001.
2000: Dong K Chang; Luigi Ricciardiello; Ajay Goel; CL Chang; C Richard Boland
Steady-state regulation of the human DNA mismatch repair system.
The Journal of biological chemistry 2000;275(24):18424-31.