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Vijay Gokhale

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Federico Medda; Emmanuelle J Meuillet; Earlphia Sells; Breland Smith; Hui-Hua Chang; Shashi Chappeta; Justin Dietrich; Vijay Gokhale; Christopher Hulme
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.
Christine E Kaiser; Danzhou Yang; Vijay Gokhale; Laurence H Hurley
Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay.
Bhumasamudram Jagadish; Eugene A. Mash Jr.; Tarik J Ozumerzifon; Ali M Ahad; Vijay Gokhale; Gerald P Guntle; Dezheng Zhao; Natarajan Raghunand
Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives.

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2013: Federico Medda; Emmanuelle J Meuillet; Earlphia Sells; Breland Smith; Hui-Hua Chang; Shashi Chappeta; Justin Dietrich; Vijay Gokhale; Christopher Hulme
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.
Bioorganic & medicinal chemistry letters 2013;23(2):528-31.
2013: Christine E Kaiser; Danzhou Yang; Vijay Gokhale; Laurence H Hurley
Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay.
Topics in current chemistry 2013;330():1-21.
2012: Bhumasamudram Jagadish; Eugene A. Mash Jr.; Tarik J Ozumerzifon; Ali M Ahad; Vijay Gokhale; Gerald P Guntle; Dezheng Zhao; Natarajan Raghunand
Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives.
Journal of medicinal chemistry 2012;55(23):10378-86.
2012: Breland Smith; Federico Medda; Travis Dunckley; Vijay Gokhale; Christopher Hulme
Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?
ACS chemical neuroscience 2012;3(11):857-72.
2012: Hui-Hua Chang; Vijay Gokhale; Zuohe Song; Tina Tripp; Lee Wisner; Emmanuelle J Meuillet
Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.
Investigational new drugs 2012;30(5):1865-77.
2012: Peda V L Boddupally; Tracy A Brooks; Biswanath De; Vijay Gokhale; Seongmin Hahn; Cristina Beman; Laurence H Hurley
Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.
Journal of medicinal chemistry 2012;55(13):6076-86.
2012: Breland Smith; Federico Medda; Emmanuelle J Meuillet; Hui-Hua Chang; Angela Davis; Justin Dietrich; Vijay Gokhale; Christopher Hulme
Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.
Bioorganic & medicinal chemistry letters 2012;22(10):3567-70.
2010: Natarajan Raghunand; Gerald P Guntle; Vijay Gokhale; Gary S Nichol; Eugene A. Mash Jr.; Bhumasamudram Jagadish
Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging.
Journal of medicinal chemistry 2010;53(18):6747-57.
2010: Justin Dietrich; Vijay Gokhale; Xiadong Wang; Laurence H Hurley; Gary A Flynn
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors.
Bioorganic & medicinal chemistry 2010;18(1):292-304.
2009: Thomas S Dexheimer; Steven S Carey; Song Zuohe; Vijay Gokhale; Xiaohui Hu; Lauren B Murata; Estelle M Maes; Andrzej Weichsel; Daekyu Sun; Emmanuelle J Meuillet; William R Montfort; Laurence H Hurley
NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).
Molecular cancer therapeutics 2009;8(5):1363-77.
2008: Steven S Carey; Mary Gleason-Guzman; Vijay Gokhale; Laurence H Hurley
Psorospermin structural requirements for P-glycoprotein resistance reversal.
Molecular cancer therapeutics 2008;7(11):3617-23.
2008: Daruka Mahadevan; Garth Powis; Eugene A. Mash Jr.; Benjamin George; Vijay Gokhale; Shuxing Zhang; Kishore Shakalya; Lei Du-Cuny; Margareta I Berggren; M Ahad Ali; Umasish Jana; Nathan T Ihle; Sylvestor Moses; Chloe Franklin; Satya Narayan; Nikhil Shirahatti; Emmanuelle J Meuillet
Discovery of a novel class of AKT pleckstrin homology domain inhibitors.
Molecular cancer therapeutics 2008;7(9):2621-32.
2008: Kexiao Guo; Vijay Gokhale; Laurence H Hurley; Daekyu Sun
Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene.
Nucleic acids research 2008;36(14):4598-608.
2008: Robert P Erickson; Charlene A McQueen; Binh Chau; Vijay Gokhale; Masahi Uchiyama; Atsushi Toyoda; Fumiwo Ejima; Naka Maho; Yoshiyuki Sakaki; Yoichi Gondo
An N-ethyl-N-nitrosourea-induced mutation in N-acetyltransferase 1 in mice.
Biochemical and biophysical research communications 2008;370(2):285-8.
2007: Ashley A Fisher; Matthew T Labenski; Srinivas Malladi; Vijay Gokhale; Martina E Bowen; Rania S Milleron; Shawn B Bratton; Terrence J Monks; Serrine S Lau
Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.
Biochemistry 2007;46(39):11090-100.
2007: Kexiao Guo; Alan Pourpak; Kara Beetz-Rogers; Vijay Gokhale; Daekyu Sun; Laurence H Hurley
Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene.
Journal of the American Chemical Society 2007;129(33):10220-8.
2007: Ming Zhu; Vijay Gokhale; Lajos Szabo; Ruben M Munoz; Hyounggee Baek; Sridevi Bashyam; Laurence H Hurley; Daniel Von Hoff; Haiyong Han
Identification of a novel inhibitor of urokinase-type plasminogen activator.
Molecular cancer therapeutics 2007;6(4):1348-56.
2007: Zuohe Song; Negin Saghafi; Vijay Gokhale; Marc Brabant; Emmanuelle J Meuillet
Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster.
Experimental cell research 2007;313(6):1161-71.
2007: Yong Qin; Evonne M Rezler; Vijay Gokhale; Daekyu Sun; Laurence H Hurley
Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4.
Nucleic acids research 2007;35(22):7698-713.
2005: Bret J Stephens; Haiyong Han; Vijay Gokhale; Daniel Von Hoff
PRL phosphatases as potential molecular targets in cancer.
Molecular cancer therapeutics 2005;4(11):1653-61.
2005: Jeyaprakashnarayanan Seenisamy; Sridevi Bashyam; Vijay Gokhale; Hariprasad Vankayalapati; Daekyu Sun; Adam Siddiqui-Jain; Nicole Streiner; Kazuo Shin-Ya; Elizabeth White; David W. Wilson; Laurence H Hurley
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.
Journal of the American Chemical Society 2005;127(9):2944-59.
2004: Jeyaprakashnarayanan Seenisamy; Evonne M Rezler; Tiffanie J Powell; Denise Tye; Vijay Gokhale; Chandana Sharma Joshi; Adam Siddiqui-Jain; Laurence H Hurley
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.
Journal of the American Chemical Society 2004;126(28):8702-9.