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Alan Goldberg

Research Profile

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Publications

TOP 3
Bas J Blaauboer; Kim Boekelheide; Harvey J Clewell; Mardas Daneshian; Milou M L Dingemans; Alan M Goldberg; Marjoke Heneweer; Joanna Jaworska; Nynke I Kramer; Marcel Leist; Hasso Seibert; Emanuela Testai; Rob J Vandebriel; James D Yager; Joanne Zurlo
The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans.
Anna K Bal-Price; Sandra Coecke; Lucio Costa; Kevin M Crofton; Ellen Fritsche; Alan M Goldberg; Philippe Grandjean; Pamela J Lein; Abby Li; Roberto Lucchini; William R Mundy; Stephanie Padilla; Antonio M Persico; Andrea Seiler; Joachim Kreysa
Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation.
David A Basketter; Bas Blaauboer; Robert Burrier; Harvey Clewell; Mardas Daneshian; Chantra Eskes; Alan M Goldberg; Nina Hasiwa; Sebastian Hoffmann; Joanna Jaworska; Ian Kimber; Thomas B Knudsen; Robert Landsiedel; Marcel Leist; PAUL LOCKE; Gavin Maxwell; James McKim; Emily A McVey; Gladys Ouédraogo; Grace Patlewicz; Olavi Pelkonen; Erwin Roggen; Annamaria Rossi; Costanza Rovida; Irmela Ruhdel; Andreas Schepky; Greet Schoeters; Michael Schwarz; Nigel Skinner; Kerstin Trentz; Marian Turner; Philippe Vanparys; James D Yager; Joanne Zurlo; Thomas Hartung
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

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All Publications

2012: Bas J Blaauboer; Kim Boekelheide; Harvey J Clewell; Mardas Daneshian; Milou M L Dingemans; Alan M Goldberg; Marjoke Heneweer; Joanna Jaworska; Nynke I Kramer; Marcel Leist; Hasso Seibert; Emanuela Testai; Rob J Vandebriel; James D Yager; Joanne Zurlo
The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans.
ALTEX 2012;29(4):411-25.
2012: Anna K Bal-Price; Sandra Coecke; Lucio Costa; Kevin M Crofton; Ellen Fritsche; Alan M Goldberg; Philippe Grandjean; Pamela J Lein; Abby Li; Roberto Lucchini; William R Mundy; Stephanie Padilla; Antonio M Persico; Andrea Seiler; Joachim Kreysa
Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation.
ALTEX 2012;29(2):202-15.
2012: David A Basketter; Bas Blaauboer; Robert Burrier; Harvey Clewell; Mardas Daneshian; Chantra Eskes; Alan M Goldberg; Nina Hasiwa; Sebastian Hoffmann; Joanna Jaworska; Ian Kimber; Thomas B Knudsen; Robert Landsiedel; Marcel Leist; PAUL LOCKE; Gavin Maxwell; James McKim; Emily A McVey; Gladys Ouédraogo; Grace Patlewicz; Olavi Pelkonen; Erwin Roggen; Annamaria Rossi; Costanza Rovida; Irmela Ruhdel; Andreas Schepky; Greet Schoeters; Michael Schwarz; Nigel Skinner; Kerstin Trentz; Marian Turner; Philippe Vanparys; James D Yager; Joanne Zurlo; Thomas Hartung
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.
ALTEX 2012;29(1):3-91.
2011: Mardas Daneshian; Alan M Goldberg; Franz Gruber; Thomas Hartung; Mohammad A Akbarsha; Bas J Blaauboer; Francesca Caloni; Pierre Cosson; rodger curren; frauke ohl; Walter Pfaller; Jan van der Valk; Pilar Vinardell; Joanne Zurlo; Marcel Leist
A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation.
ALTEX 2011;28(4):341-52.
2011: Kevin M Crofton; William R Mundy; Pamela J Lein; Anna Bal-Price; Sandra Coecke; Andrea E M Seiler; Holger Knaut; Leonora Buzanska; Alan M Goldberg
Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.
ALTEX 2011;28(1):9-15.
2011: Neil Wilcox; Alan M Goldberg
Food for thought ... on validation. A puzzle or a mystery: an approach founded on new science.
ALTEX 2011;28(1):3-8.
2010: Ellen K Silbergeld; Meghan Davis; Beth Feingold; Bath Feingold; Alan M Goldberg; Jay Graham; Jessica Leibler; Amy Peterson; Lance B Price
New infectious diseases and industrial food animal production.
Emerging infectious diseases 2010;16(9):1503; author reply 1504.
2010: Thomas Hartung; Leon Bruner; rodger curren; Chantra Eskes; Alan M Goldberg; Pauline McNamee; Laurie Scott; Valérie Zuang
First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain.
ALTEX 2010;27(1):43-51.
2009: Alan M Goldberg
The role of an academic centre.
Alternatives to laboratory animals : ATLA 2009;37 Suppl 2():19-21.
2007: John MATTHEW Balbus; Andrew D Maynard; Vicki L Colvin; Vincent Castranova; George P Daston; Richard A Denison; Kevin L Dreher; Peter L Goering; Alan M Goldberg; Kristen M Kulinowski; Nancy A Monteiro-Riviere; Günter Oberdörster; Gilbert S Omenn; Kent E Pinkerton; Kenneth S Ramos; Kathleen M Rest; Jennifer B Sass; Ellen K Silbergeld; Brian A Wong
Meeting report: hazard assessment for nanoparticles--report from an interdisciplinary workshop.
Environmental health perspectives 2007;115(11):1654-9.
2007: Sandra Coecke; Alan M Goldberg; Sandra Allen; Leonora Buzanska; Gemma Calamandrei; Kevin Crofton; Lars Hareng; Thomas Hartung; Holger Knaut; Paul Honegger; Miriam Jacobs; Pamela J Lein; Abby Li; William Mundy; David Owen; Steffen Schneider; Ellen K Silbergeld; Torsten Reum; Tomás Trnovec; Florianne Monnet-Tschudi; Anna Bal-Price
Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies.
Environmental health perspectives 2007;115(6):924-31.
2007: Pamela J Lein; PAUL LOCKE; Alan M Goldberg
Meeting report: alternatives for developmental neurotoxicity testing.
Environmental health perspectives 2007;115(5):764-8.
2006: Richard A Becker; Christopher J Borgert; Simon Webb; Jay Ansell; Sara Amundson; Christopher Portier; Alan M Goldberg; Leon H Bruner; Andrew Rowan; rodger curren; William T Stott
Report of an ISRTP workshop: progress and barriers to incorporating alternative toxicological methods in the U.S.
Regulatory toxicology and pharmacology : RTP 2006;46(1):18-22.
2006: Alan M Goldberg; Thomas Hartung
Protecting more than animals.
Scientific American 2006;294(1):84-91.
2005: Pamela J Lein; PAUL LOCKE; Ellen K Silbergeld; Alan M Goldberg
In vitro and other alternative approaches to developmental neurotoxicity testing (DNT).
Environmental toxicology and pharmacology 2005;19(3):735-44.
2004: Alan M Goldberg
Animals and alternatives: societal expectations and scientific need.
Alternatives to laboratory animals : ATLA 2004;32(6):545-51.
2004: Alessandra Gennari; Christine van den Berghe; Silvia Casati; José Castell; Cecilia Clemedson; Sandra Coecke; Alessandra Colombo; rodger curren; Gianni Dal Negro; Alan M Goldberg; Catherine Gosmore; Thomas Hartung; Ingrid Langezaal; Iglika Lessigiarska; Wilfred Maas; Inge Mangelsdorf; Ralph E Parchment; Pilar Prieto; Juan Riego Sintes; Michael Ryan; Gabriele Schmuck; Katherine Stitzel; William S Stokes; Joan-Albert Vericat; Laura Gribaldo
Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50.
Alternatives to laboratory animals : ATLA 2004;32(4):437-59.
2004: Sidney Green; Alan M Goldberg
TestSmart and toxic ignorance.
Alternatives to laboratory animals : ATLA 2004;32 Suppl 1A():359-63.
2003: Alicia Z Karas; Alan M Goldberg
Recognizing signs of pain.
Journal of the American Veterinary Medical Association 2003;223(3):298-9; author reply 299.
2002: Alan M Goldberg
Use of animals in research: a science--society controversy? The American perspective: animal welfare issues.
ALTEX 2002;19(3):137-9.
2001: S Green; Alan M Goldberg; J Zurlo
TestSmart-high production volume chemicals: an approach to implementing alternatives into regulatory toxicology.
Toxicological sciences : an official journal of the Society of Toxicology 2001;63(1):6-14.
2001: S Green; Alan M Goldberg; J Zurlo
The TestSmart-HPV Program--development of an integrated approach for testing high production volume chemicals.
Regulatory toxicology and pharmacology : RTP 2001;33(2):105-9.
2000: S Tongaree; Alan M Goldberg; DR Flanagan; RI Poust
The effects of pH and PEG 400-water cosolvents on oxytetracycline-magnesium complex formation and stability.
Pharmaceutical development and technology 2000;5(2):189-99.
1999: J Zurlo; Alan M Goldberg
The role of an academic center in promoting common goals.
Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees 1999;8(1):58-63.
1998: Alan M Goldberg; H I Maibach
Dermal toxicity: alternative methods for risk assessment.
Environmental health perspectives 1998;106 Suppl 2():493-6.
1998: rodger curren; L Bruner; Alan M Goldberg; E Walum
13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): validation and acute toxicity testing.
Environmental health perspectives 1998;106 Suppl 2():419-25.
1996: J Zurlo; D Rudacille; Alan M Goldberg
The three Rs: the way forward.
Environmental health perspectives 1996;104(8):878-80.
1996: Alan M Goldberg; J Zurlo; D Rudacille
The three Rs and biomedical research.
Science (New York, N.Y.) 1996;272(5267):1403.
1995: Michael Balls; Alan M Goldberg; Julia H Fentem; Caren L Broadhead; Rex L Burch; Michael F W Festing; John M Frazier; Coenraad F M Hendriksen; Margaret Jennings; Margot D O van der Kamp; David B Morton; Andrew N Rowan; Claire Russell; William M S Russell; Horst Spielmann; Martin L Stephens; William S Stokes; Donald W Straughan; James D Yager; Joanne Zurlo; Bert F M van Zutphen
The three Rs: the way forward: the report and recommendations of ECVAM Workshop 11.
Alternatives to laboratory animals : ATLA 1995;23(6):838-66.
1995: Alan M Goldberg
Development of alternative methods.
The Journal of toxicological sciences 1995;20(4):443-9.
1995: Andrew Rowan; Alan M Goldberg
Responsible animal research: a riff of Rs.
Alternatives to laboratory animals : ATLA 1995;23(3):306-11.
1993: Alan M Goldberg; J M Frazier; D Brusick; M S Dickens; O Flint; S D Gettings; Richard N Hill; R L Lipnick; K J Renskers; J A Bradlaw
Framework for validation and implementation of in vitro toxicity tests.
In vitro cellular & developmental biology. Animal 1993;29A(9):688-92.
1993: Alan M Goldberg; J M Frazier; D Brusick; M S Dickens; O Flint; S D Gettings; Richard N Hill; R L Lipnick; K J Renskers; J A Bradlaw
Report of the Validation and Technology Transfer Committee of the Johns Hopkins Center for Alternatives to Animal Testing. Framework for validation and implementation of in vitro toxicity tests.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(5):563-72.
1992: Alan M Goldberg; P M Silber
Status of in vitro ocular irritation testing.
Lens and eye toxicity research 1992;9(3-4):161-92.
1989: Alan M Goldberg; J M Frazier
Alternatives to animals in toxicity testing.
Scientific American 1989;261(2):24-30.
1987: Alan M Goldberg
The need to assess the safety of commercial and consumer products.
Toxicology letters 1987;35(2-3):vii-xi.
1987: Alan M Goldberg
Approaches to the development of in vitro neurotoxicological methods.
Progress in clinical and biological research 1987;253():1-11.
1985: Alan M Goldberg
An approach to the development of in vitro toxicological methods.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1985;23(2):205-8.
1985: A N Rowan; Alan M Goldberg
Perspectives on alternatives to current animal testing techniques in preclinical toxicology.
Annual review of pharmacology and toxicology 1985;25():225-47.
1984: S M Sato; J M Frazier; Alan M Goldberg
Perturbation of a hippocampal zinc-binding pool after postnatal lead exposure in rats.
Experimental neurology 1984;85(3):620-30.
1984: Alan M Goldberg
The Johns Hopkins Center for Alternatives to Animal Testing.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1984;4(4):517-8.
1984: S M Sato; J M Frazier; Alan M Goldberg
A kinetic study of the in vivo incorporation of 65ZN into the rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1984;4(6):1671-5.
1984: S M Sato; J M Frazier; Alan M Goldberg
The distribution and binding of zinc in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1984;4(6):1662-70.
1984: Alan M Goldberg
Approaches to the development of in vitro toxicological methods.
Pharmacological reviews 1984;36(2 Suppl):173S-175S.
1982: E L Lakomaa; S Sato; Alan M Goldberg; J M Frazier
The effect of sodium diethyldithiocarbamate treatment on copper and zinc concentrations in rat brain.
Toxicology and applied pharmacology 1982;65(2):286-90.
1982: W R Millington; Alan M Goldberg
Precursor dependence of acetylcholine release from rat brain in vitro.
Brain research 1982;243(2):263-70.
1982: Hanna Ksiezak-Reding; Alan M Goldberg
The role of chloride in acetylcholine metabolism.
Journal of neurochemistry 1982;38(1):121-9.
1980: G G Bierkamper; Alan M Goldberg
Release of acetylcholine from the vascular perfused rat phrenic nerve-hemidiaphragm.
Brain research 1980;202(1):234-7.
1980: Neville Brookes; D R Burt; Alan M Goldberg; G G Bierkamper
The influence of muscle-conditioned medium on cholinergic maturation in spinal cord cell cultures.
Brain research 1980;186(2):474-9.
1980: Alan M Goldberg; Neville Brookes; D R Burt
The use of spinal cord cell cultures in the study of neurotoxicological agents.
Toxicology 1980;17(2):233-5.
1980: Alan M Goldberg
Mechanisms of neurotoxicity as studied in tissue culture systems.
Toxicology 1980;17(2):201-8.
1979: Robert S Fitzgerald; G A Dehghani; A Anand; Alan M Goldberg
The failure of differences in neurally contained acetylcholine to explain differences between carotid body and aortic body chemoreception.
Brain research 1979;179(1):176-80.
1979: Gihan I. Tennekoon; C S Aitchison; J Frangia; Donald L Price; Alan M Goldberg
Chronic lead intoxication: effects on developing optic nerve.
Annals of neurology 1979;5(6):558-64.
1979: Neville Brookes; Alan M Goldberg
Choline acetyltransferase activity of spinal cord cell cultures is increased by diisopropylphosphorofluoridate.
Life sciences 1979;24(10):889-93.
1979: Alan M Goldberg
The effects of inorganic lead on cholinergic transmission.
Progress in brain research 1979;49():465-70.
1978: Alan M Goldberg; A P Lentz; Robert S Fitzgerald
Neurotransmitter mechanisms in the carotid body: absence of ACH in the carotid sinus nerve.
Brain research 1978;140(2):374-7.
1978: I J Butler; Daniel B Drachman; Alan M Goldberg
The effect of disuse on cholinergic enzymes.
The Journal of physiology 1978;274():593-600.
1977: Alan M Goldberg
Is deanol a precursor of acetylcholine?
Diseases of the nervous system 1977;38(12 Pt 2):16-20.
1977: P T Carroll; Ellen K Silbergeld; Alan M Goldberg
Alteration of central cholinergic function by chronic lead acetate exposure.
Biochemical pharmacology 1977;26(5):397-402.
1977: D M Jacobowitz; Alan M Goldberg
Determination of acetylcholine in discrete regions of the rat brain.
Brain research 1977;122(3):575-7.
1975: P T Carroll; Alan M Goldberg
Relative importance of choline transport to spontaneous and potassium depolarized release of ACh.
Journal of neurochemistry 1975;25(4):523-7.
1975: J H Morrison; D S Olton; Alan M Goldberg; Ellen K Silbergeld
Alterations in consummatory behavior of mice produced by dietary exposure to inorganic lead.
Developmental psychobiology 1975;8(5):389-96.
1975: Ellen K Silbergeld; Alan M Goldberg
Pharmacological and neurochemical investigations of lead-induced hyperactivity.
Neuropharmacology 1975;14(5-6):431-44.
1975: R D Krell; Alan M Goldberg
Effect of choline acetyltransferase inhibitors on mouse and guinea-pig brain choline and acetylcholine.
Biochemical pharmacology 1975;24(3):391-6.
1974: H Rommelspacher; Alan M Goldberg; Michael J Kuhar
Action of hemicholinium-3 on cholinergic nerve terminals after alteration of neuronal impulse flow.
Neuropharmacology 1974;13(10-11):1015-23.
1974: Ellen K Silbergeld; J T Fales; Alan M Goldberg
The effects of inorganic lead on the neuromuscular junction.
Neuropharmacology 1974;13(9):795-801.
1974: Ellen K Silbergeld; Alan M Goldberg
Hyperactivity: a lead-induced behavior disorder.
Environmental health perspectives 1974;7():227-32.
1974: Ellen K Silbergeld; J T Fales; Alan M Goldberg
Evidence for a junctional effect of lead on neuromuscular function.
Nature 1974;247(5435):49-50.
1974: Ellen K Silbergeld; Alan M Goldberg
Lead-induced behavioral dysfunction: an animal model of hyperactivity.
Experimental neurology 1974;42(1):146-57.
1973: R D Krell; Alan M Goldberg
Effect of acute and chronic administration of lithium on steady-state levels of mouse brain choline and acetylcholine.
Biochemical pharmacology 1973;22(24):3289-91.
1973: B L Welch; Alan M Goldberg
Adrenal choline acetyltransferase activity: sustained effects of chronic intermittent psychological and psychosocial stimulation.
The International journal of neuroscience 1973;5(3):95-9.
1973: Alan M Goldberg; R E McCaman
The determination of picomole amounts of acetylcholine in mammalian brain.
Journal of neurochemistry 1973;20(1):1-8.
1972: Alan M Goldberg; B L Welch
Adaptation of the adrenal medulla: sustained increase in choline acetyltransferase by psychosocial stimulation.
Science (New York, N.Y.) 1972;178(4058):319-20.
1972: J M Spyker; S B Sparber; Alan M Goldberg
Subtle consequences of methylmercury exposure: behavioral deviations in offspring of treated mothers.
Science (New York, N.Y.) 1972;177(4049):621-3.
1972: Alan M Goldberg; J J Pollock; E R Hartman; C R Craig
Alterations in cholinergic enzymes during the development of cobalt-induced epilepsy in the rat.
Neuropharmacology 1972;11(2):253-9.
1971: R E McCaman; S A Dewhurst; Alan M Goldberg
Choline kinase; assay and partial purification.
Analytical biochemistry 1971;42(1):171-7.
1970: A K Ritchie; Alan M Goldberg
Vesicular and synaptoplasmic synthesis of acetylcholine.
Science (New York, N.Y.) 1970;169(3944):489-90.
1969: A A Kaita; Alan M Goldberg
Control of acetylcholine synthesis--the inhibition of choline acetyltransferase by acetylcholine.
Journal of neurochemistry 1969;16(7):1185-91.
1969: Alan M Goldberg; A A Kaita; R E McCaman
Microdetermination of choline acetyltransferase--a comparison of reinecke vs. periodide precipitation.
Journal of neurochemistry 1969;16(5):823-4.
1968: Alan M Goldberg; R E McCaman
Betaine aldehyde dehydrogenase: assay and partial purification.
Biochimica et biophysica acta 1968;167(1):186-9.
1968: D A Mayhew; Alan M Goldberg; P H Wright
The influence of cholinomimetics upon insulin secretion.
Diabetes 1968;17():308-9.
1967: Alan M Goldberg; R E McCaman
A quantitative microchemical study of choline acetyltransferase and acetylcholinesterase in the cerebellum of several species.
Life sciences 1967;6(14):1493-500.
1967: M B Wallach; Alan M Goldberg; F E Shideman
The synthesis of labeled acetylcholine by the isolated cat heart and its release by vagal stimulation.
International journal of neuropharmacology 1967;6(4):317-23.
1967: Alan M Goldberg; F E Shideman
The negative inotropic action of ephedrine and its modification by various agents.
The Journal of pharmacology and experimental therapeutics 1967;157(1):49-54.