Todd Golde

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Chemicals & Drugs

Disorders

Alzheimer Disease

Living Beings

Anatomy

Physiology

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Publications

TOP 3
Golde Todd E; Kukar Thomas L
Medicine. Avoiding unintended toxicity.
Zhang Yong-Jie; Xu Ya-Fei; Cook Casey; Gendron Tania F; Roettges Paul; Link Christopher D; Lin Wen-Lang; Tong Jimei; Castanedes-Casey Monica; Ash Peter; Gass Jennifer; Rangachari Vijayaraghavan; Buratti Emanuele; Baralle Francisco; Golde Todd E; Dickson Dennis W; Petrucelli Leonard
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Golde Todd E; Wolfe Michael S; Greenbaum Doron C
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.

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All Publications

2009: Golde Todd E; Kukar Thomas L
Medicine. Avoiding unintended toxicity.
Science (New York, N.Y.) 2009;324(5927):603-4.
2009: Zhang Yong-Jie; Xu Ya-Fei; Cook Casey; Gendron Tania F; Roettges Paul; Link Christopher D; Lin Wen-Lang; Tong Jimei; Castanedes-Casey Monica; Ash Peter; Gass Jennifer; Rangachari Vijayaraghavan; Buratti Emanuele; Baralle Francisco; Golde Todd E; Dickson Dennis W; Petrucelli Leonard
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7607-12.
2009: Golde Todd E; Wolfe Michael S; Greenbaum Doron C
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.
Seminars in cell & developmental biology 2009;20(2):225-30.
2009: McAlpine Fiona E; Lee Jae-Kyung; Harms Ashley S; Ruhn Kelly A; Blurton-Jones Mathew; Hong John; Das Pritam; Golde Todd E; LaFerla Frank M; Oddo Salvatore; Blesch Armin; Tansey Malú G
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology.
Neurobiology of disease 2009;34(1):163-77.
2009: Rahimi Nader; Golde Todd E; Meyer Rosana D
Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells.
Cancer research 2009;69(6):2607-14.
2009: Golde Todd E; Das Pritam; Levites Yona
Quantitative and mechanistic studies of Abeta immunotherapy.
CNS & neurological disorders drug targets 2009;8(1):31-49.
2009: Cho Ok Hyun; Shin Hyun Mu; Miele Lucio; Golde Todd E; Fauq Abdul; Minter Lisa M; Osborne Barbara A
Notch regulates cytolytic effector function in CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3380-9.
2009: Joshi Ila; Minter Lisa M; Telfer Janice; Demarest Renée M; Capobianco Anthony J; Aster Jon C; Sicinski Piotr; Fauq Abdul; Golde Todd E; Osborne Barbara A
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.
Blood 2009;113(8):1689-98.
2009: Garcia-Alloza Monica; Subramanian Meenakshi; Thyssen Diana; Borrelli Laura A; Fauq Abdul; Das Pritam; Golde Todd E; Hyman Bradley T; Bacskai Brian J
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.
Molecular neurodegeneration 2009;4():19.
2009: Rizzo Paola; Osipo Clodia; Pannuti Antonio; Golde Todd; Osborne Barbara; Miele Lucio
Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer.
Advances in enzyme regulation 2009;49(1):134-41.
2009: Parvanova Iana; Epiphanio Sabrina; Fauq Abdul; Golde Todd E; Prudêncio Miguel; Mota Maria M
A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity.
PloS one 2009;4(4):e5078.
2009: Golde Todd E
The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease.
Molecular neurodegeneration 2009;4():8.
2009: Golde Todd E; Petrucelli Leonard
"What kills neurons in neurodegenerative diseases?", a review series in an open access journal.
Molecular neurodegeneration 2009;4():7.
2008: Rizzo P; Osipo C; Foreman K; Golde T; Osborne B; Miele L
Rational targeting of Notch signaling in cancer.
Oncogene 2008;27(38):5124-31.
2008: Samon Jeremy B; Champhekar Ameya; Minter Lisa M; Telfer Janice C; Miele Lucio; Fauq Abdul; Das Pritam; Golde Todd E; Osborne Barbara A
Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells.
Blood 2008;112(5):1813-21.
2008: Jiang Peizhou; Ko Li-wen; Jansen Karen R; Golde Todd E; Yen Shu-Hui
Using leucine zipper to facilitate alpha-synuclein assembly.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3165-74.
2008: Osipo C; Patel P; Rizzo P; Clementz A G; Hao L; Golde T E; Miele L
ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor.
Oncogene 2008;27(37):5019-32.
2008: Spilman Patricia; Lessard Pierre; Sattavat Mamta; Bush Clarissa; Tousseyn Thomas; Huang Eric J; Giles Kurt; Golde Todd; Das Pritam; Fauq Abdul; Prusiner Stanley B; Dearmond Stephen J
A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10595-600.
2008: Kukar Thomas L; Ladd Thomas B; Bann Maralyssa A; Fraering Patrick C; Narlawar Rajeshwar; Maharvi Ghulam M; Healy Brent; Chapman Robert; Welzel Alfred T; Price Robert W; Moore Brenda; Rangachari Vijayaraghavan; Cusack Bernadette; Eriksen Jason; Jansen-West Karen; Verbeeck Christophe; Yager Debra; Eckman Christopher; Ye Wenjuan; Sagi Sarah; Cottrell Barbara A; Torpey Justin; Rosenberry Terrone L; Fauq Abdul; Wolfe Michael S; Schmidt Boris; Walsh Dominic M; Koo Edward H; Golde Todd E
Substrate-targeting gamma-secretase modulators.
Nature 2008;453(7197):925-9.
2008: Kim Jungsu; Miller Victor M; Levites Yona; West Karen Jansen; Zwizinski Craig W; Moore Brenda D; Troendle Fredrick J; Bann Maralyssa; Verbeeck Christophe; Price Robert W; Smithson Lisa; Sonoda Leilani; Wagg Kayleigh; Rangachari Vijayaraghavan; Zou Fanggeng; Younkin Steven G; Graff-Radford Neill; Dickson Dennis; Rosenberry Terrone; Golde Todd E
BRI2 (ITM2b) inhibits Abeta deposition in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(23):6030-6.
2008: Czirr Eva; Cottrell Barbara A; Leuchtenberger Stefanie; Kukar Thomas; Ladd Thomas B; Esselmann Hermann; Paul Sabine; Schubenel Robert; Torpey Justin W; Pietrzik Claus U; Golde Todd E; Wiltfang Jens; Baumann Karlheinz; Koo Edward H; Weggen Sascha
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
The Journal of biological chemistry 2008;283(25):17049-54.
2008: Buxbaum Joel N; Ye Zhengyi; Reixach Natàlia; Friske Linsey; Levy Coree; Das Pritam; Golde Todd; Masliah Eliezer; Roberts Amanda R; Bartfai Tamas
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2681-6.
2008: Palaga Tanapat; Buranaruk Chayanit; Rengpipat Sirirat; Fauq Abdul H; Golde Todd E; Kaufmann Stefan H E; Osborne Barbara A
Notch signaling is activated by TLR stimulation and regulates macrophage functions.
European journal of immunology 2008;38(1):174-83.
2008: Osipo Clodia; Golde Todd E; Osborne Barbara A; Miele Lucio A
Off the beaten pathway: the complex cross talk between Notch and NF-kappaB.
Laboratory investigation; a journal of technical methods and pathology 2008;88(1):11-7.
2008: Kukar Thomas; Golde Todd E
Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.
Current topics in medicinal chemistry 2008;8(1):47-53.
2007: Fauq Abdul H; Simpson Katherine; Maharvi Ghulam M; Golde Todd; Das Pritam
A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.
Bioorganic & medicinal chemistry letters 2007;17(22):6392-5.
2007: Li Tong; Wen Hongjin; Brayton Cory; Das Pritam; Smithson Lisa A; Fauq Abdul; Fan Xing; Crain Barbara J; Price Donald L; Golde Todd E; Eberhart Charles G; Wong Philip C
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.
The Journal of biological chemistry 2007;282(44):32264-73.
2007: Galasko Douglas R; Graff-Radford Neil; May Susanne; Hendrix Suzanne; Cottrell Barbara A; Sagi Sarah A; Mather Gary; Laughlin Mark; Zavitz Kenton H; Swabb Edward; Golde Todd E; Murphy Michael P; Koo Edward H
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals.
Alzheimer disease and associated disorders 2007;21(4):292-9.
2007: Ostrowski Stephen M; Wilkinson Brandy L; Golde Todd E; Landreth Gary
Statins reduce amyloid-beta production through inhibition of protein isoprenylation.
The Journal of biological chemistry 2007;282(37):26832-44.
2007: Curry Christine L; Reed Laura L; Broude Eugenia; Golde Todd E; Miele Lucio; Foreman Kimberly E
Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling.
Molecular cancer therapeutics 2007;6(7):1983-92.
2007: Kim Jungsu; Onstead Luisa; Randle Suzanne; Price Robert; Smithson Lisa; Zwizinski Craig; Dickson Dennis W; Golde Todd; McGowan Eileen
Abeta40 inhibits amyloid deposition in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(3):627-33.
2007: Golde Todd E
The pathogenesis of Alzheimer's disease and the role of Abeta42.
CNS spectrums 2007;12(1 Suppl 1):4-6.
2007: Kukar Thomas; Prescott Sonya; Eriksen Jason L; Holloway Vallie; Murphy M Paul; Koo Edward H; Golde Todd E; Nicolle Michelle M
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
BMC neuroscience 2007;8():54.
2007: Lawlor Patricia A; Bland Ross J; Das Pritam; Price Robert W; Holloway Vallie; Smithson Lisa; Dicker Bridget L; During Matthew J; Young Deborah; Golde Todd E
Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.
Molecular neurodegeneration 2007;2():11.
2006: Miele Lucio; Golde Todd; Osborne Barbara
Notch signaling in cancer.
Current molecular medicine 2006;6(8):905-18.
2006: Golde Todd E; Dickson Dennis; Hutton Michael
Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease.
Current Alzheimer research 2006;3(5):421-30.
2006: Levites Yona; Smithson Lisa A; Price Robert W; Dakin Rachel S; Yuan Bin; Sierks Michael R; Kim Jungsu; McGowan Eileen; Reed Dana Kim; Rosenberry Terrone L; Das Pritam; Golde Todd E
Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2576-8.
2006: Levites Yona; Jansen Karen; Smithson Lisa A; Dakin Rachel; Holloway Vallie M; Das Pritam; Golde Todd E
Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(46):11923-8.
2006: Das Pritam; Golde Todd
Dysfunction of TGF-beta signaling in Alzheimer's disease.
The Journal of clinical investigation 2006;116(11):2855-7.
2006: Golde Todd E
Disease modifying therapy for AD?
Journal of neurochemistry 2006;99(3):689-707.
2006: Boeve Bradley F; Baker Matt; Dickson Dennis W; Parisi Joseph E; Giannini Caterina; Josephs Keith A; Hutton Michael; Pickering-Brown Stuart M; Rademakers Rosa; Tang-Wai David; Jack Clifford R; Kantarci Kejal; Shiung Maria M; Golde Todd; Smith Glenn E; Geda Yonas E; Knopman David S; Petersen Ronald C
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Brain : a journal of neurology 2006;129(Pt 11):3103-14.
2006: Nyborg Andrew C; Ladd Thomas B; Jansen Karen; Kukar Thomas; Golde Todd E
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1671-9.
2006: Sato Toru; Nyborg Andrew C; Iwata Nobuhisa; Diehl Thekla S; Saido Takaomi C; Golde Todd E; Wolfe Michael S
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.
Biochemistry 2006;45(28):8649-56.
2006: Nguyen Justin H; Yamamoto Satoshi; Steers Jeffery; Sevlever Daniel; Lin Wenlang; Shimojima Naoki; Castanedes-Casey Monica; Genco Petrina; Golde Todd; Richelson Elliott; Dickson Dennis; McKinney Michael; Eckman Christopher B
Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice.
Journal of hepatology 2006;44(6):1105-14.
2006: Klein Ronald L; Dayton Robert D; Leidenheimer Nancy J; Jansen Karen; Golde Todd E; Zweig Richard M
Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(3):517-27.
2006: Herl Lauren; Lleo Alberto; Thomas Anne V; Nyborg Andrew C; Jansen Karen; Golde Todd E; Hyman Bradley T; Berezovska Oksana
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.
Biochemical and biophysical research communications 2006;340(2):668-74.
2006: Murphy M Paul; Golde Todd E
Inclusion-body myositis and Alzheimer disease: two sides of the same coin, or different currencies altogether?
Neurology 2006;66(2 Suppl 1):S65-8.
2006: Levites Yona; Das Pritam; Price Robert W; Rochette Marjorie J; Kostura Lisa A; McGowan Eileen M; Murphy Michael P; Golde Todd E
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model.
The Journal of clinical investigation 2006;116(1):193-201.
2006: Shin Hyun Mu; Minter Lisa M; Cho Ok Hyun; Gottipati Sridevi; Fauq Abdul H; Golde Todd E; Sonenshein Gail E; Osborne Barbara A
Notch1 augments NF-kappaB activity by facilitating its nuclear retention.
The EMBO journal 2006;25(1):129-38.
2006: Wang Jun; Beher Dirk; Nyborg Andrew C; Shearman Mark S; Golde Todd E; Goate Alison
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
Journal of neurochemistry 2006;96(1):218-27.
2006: Leuchtenberger Stefanie; Kummer Markus P; Kukar Thomas; Czirr Eva; Teusch Nicole; Sagi Sarah A; Berdeaux Rebecca; Pietrzik Claus U; Ladd Thomas B; Golde Todd E; Koo Edward H; Weggen Sascha
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
Journal of neurochemistry 2006;96(2):355-65.
2006: Nyborg Andrew C; Herl Lauren; Berezovska Oksana; Thomas Anne V; Ladd Thomas B; Jansen Karen; Hyman Bradley T; Golde Todd E
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.
Molecular neurodegeneration 2006;1():16.
2006: Nyborg Andrew C; Ladd Thomas B; Zwizinski Craig W; Lah James J; Golde Todd E
Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.
Molecular neurodegeneration 2006;1():3.
2006: Das Pritam; Smithson Lisa A; Price Robert W; Holloway Vallie M; Levites Yona; Chakrabarty Paramita; Golde Todd E
Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy.
Journal of neuroinflammation 2006;3():17.
2005: Curry Christine L; Reed Laura L; Golde Todd E; Miele Lucio; Nickoloff Brian J; Foreman Kimberly E
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.
Oncogene 2005;24(42):6333-44.
2005: McGowan Eileen; Pickford Fiona; Kim Jungsu; Onstead Luisa; Eriksen Jason; Yu Cindy; Skipper Lisa; Murphy M Paul; Beard Jenny; Das Pritam; Jansen Karen; Delucia Michael; Lin Wen-Lang; Dolios Georgia; Wang Rong; Eckman Christopher B; Dickson Dennis W; Hutton Mike; Hardy John; Golde Todd
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Neuron 2005;47(2):191-9.
2005: Minter Lisa M; Turley Danielle M; Das Pritam; Shin Hyun Mu; Joshi Ila; Lawlor Rebecca G; Cho Ok Hyun; Palaga Tanapat; Gottipati Sridevi; Telfer Janice C; Kostura Lisa; Fauq Abdul H; Simpson Katherine; Such Kimberly A; Miele Lucio; Golde Todd E; Miller Stephen D; Osborne Barbara A
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.
Nature immunology 2005;6(7):680-8.
2005: Golde Todd E; Bacskai Brian J
Bringing amyloid into focus.
Nature biotechnology 2005;23(5):552-4.
2005: Kukar Thomas; Murphy Michael Paul; Eriksen Jason L; Sagi Sarah A; Weggen Sascha; Smith Tawnya E; Ladd Thomas; Khan Murad A; Kache Rajashaker; Beard Jenny; Dodson Mark; Merit Sami; Ozols Victor V; Anastasiadis Panos Z; Das Pritam; Fauq Abdul; Koo Edward H; Golde Todd E
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.
Nature medicine 2005;11(5):545-50.
2005: Golde Todd E; Janus Christopher
Homing in on intracellular Abeta?
Neuron 2005;45(5):639-42.
2005: Golde Todd E
The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease.
Brain pathology (Zurich, Switzerland) 2005;15(1):84-7.
2004: Akbari Yama; Hitt Brian D; Murphy M Paul; Dagher Nabil N; Tseng Bertrand P; Green Kim N; Golde Todd E; LaFerla Frank M
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.
Biochemical and biophysical research communications 2004;322(4):1145-52.
2004: Nyborg Andrew C; Jansen Karen; Ladd Thomas B; Fauq Abdul; Golde Todd E
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.
The Journal of biological chemistry 2004;279(41):43148-56.
2004: Nyborg Andrew C; Kornilova Anna Y; Jansen Karen; Ladd Thomas B; Wolfe Michael S; Golde Todd E
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.
The Journal of biological chemistry 2004;279(15):15153-60.
2003: Ramsden M; Nyborg A C; Murphy M P; Chang L; Stanczyk F Z; Golde T E; Pike C J
Androgens modulate beta-amyloid levels in male rat brain.
Journal of neurochemistry 2003;87(4):1052-5.
2003: Das Pritam; Chapoval Svetlana; Howard Victor; David Chella S; Golde Todd E
Immune responses against Abeta1-42 in HLA class II transgenic mice: implications for Abeta1-42 immune-mediated therapies.
Neurobiology of aging 2003;24(7):969-76.
2003: Martoglio Bruno; Golde Todd E
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs.
Human molecular genetics 2003;12 Spec No 2():R201-6.
2003: Das Pritam; Howard Victor; Loosbrock Nicole; Dickson Dennis; Murphy M Paul; Golde Todd E
Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8532-8.
2003: Palaga Tanapat; Miele Lucio; Golde Todd E; Osborne Barbara A
TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3019-24.
2003: Eriksen Jason L; Sagi Sarah A; Smith Tawnya E; Weggen Sascha; Das Pritam; McLendon D C; Ozols Victor V; Jessing Kevin W; Zavitz Kenton H; Koo Edward H; Golde Todd E
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.
The Journal of clinical investigation 2003;112(3):440-9.
2003: Weggen Sascha; Eriksen Jason L; Sagi Sarah A; Pietrzik Claus U; Ozols Victor; Fauq Abdul; Golde Todd E; Koo Edward H
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.
The Journal of biological chemistry 2003;278(34):31831-7.
2003: Sagi Sarah A; Weggen Sascha; Eriksen Jason; Golde Todd E; Koo Edward H
The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production.
The Journal of biological chemistry 2003;278(34):31825-30.
2003: Weggen Sascha; Eriksen Jason L; Sagi Sarah A; Pietrzik Claus U; Golde Todd E; Koo Edward H
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.
The Journal of biological chemistry 2003;278(33):30748-54.
2003: Oddo Salvatore; Caccamo Antonella; Shepherd Jason D; Murphy M Paul; Golde Todd E; Kayed Rakez; Metherate Raju; Mattson Mark P; Akbari Yama; LaFerla Frank M
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.
Neuron 2003;39(3):409-21.
2003: Piper Siân C; Amtul Zareen; Galiñanes-Garcia Laura; Howard Victor G; Ziani-Cherif Chewki; McLendon Chris; Rochette Marjorie J; Fauq Abdul; Golde Todd E; Murphy M Paul
Peptide-based, irreversible inhibitors of gamma-secretase activity.
Biochemical and biophysical research communications 2003;305(3):529-33.
2003: Murphy M Paul; Das Pritam; Nyborg Andrew C; Rochette Marjorie J; Dodson Mark W; Loosbrock Nicole M; Souder Terrance M; McLendon Chris; Merit Sami L; Piper Siân C; Jansen Karen R; Golde Todd E
Overexpression of nicastrin increases Abeta production.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1138-40.
2003: Golde Todd E; Eckman Christopher B
Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis.
Science's STKE : signal transduction knowledge environment 2003;2003(172):RE4.
2003: Golde Todd E
Alzheimer disease therapy: can the amyloid cascade be halted?
The Journal of clinical investigation 2003;111(1):11-8.
2002: Das Pritam; Golde Todd E
Open peer commentary regarding Abeta immunization and CNS inflammation by Pasinetti et al.
Neurobiology of aging 2002;23(5):671-4; discussion 683-4.
2002: Golde Todd E
Inflammation takes on Alzheimer disease.
Nature medicine 2002;8(9):936-8.
2002: Ponting Chris P; Hutton Mike; Nyborg Andrew; Baker Matthew; Jansen Karen; Golde Todd E
Identification of a novel family of presenilin homologues.
Human molecular genetics 2002;11(9):1037-44.
2002: Sugarman Michael C; Yamasaki Tritia R; Oddo Salvatore; Echegoyen Julio C; Murphy M Paul; Golde Todd E; Jannatipour Mehrdad; Leissring Malcolm A; LaFerla Frank M
Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6334-9.
2002: Leissring Malcolm A; Murphy M Paul; Mead Tonya R; Akbari Yama; Sugarman Michael C; Jannatipour Mehrdad; Anliker Brigitte; Müller Ulrike; Saftig Paul; De Strooper Bart; Wolfe Michael S; Golde Todd E; LaFerla Frank M
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4697-702.
2002: Murphy M Paul; Uljon Sacha N; Golde Todd E; Wang Rong
FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants.
Biochimica et biophysica acta 2002;1586(2):199-209.
2002: Amtul Zareen; Lewis Patrick A; Piper Sian; Crook Richard; Baker Matt; Findlay Kirk; Singleton Andrew; Hogg Marion; Younkin Linda; Younkin Steven G; Hardy John; Hutton Michael; Boeve Bradley F; Tang-Wai David; Golde Todd E
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
Neurobiology of disease 2002;9(2):269-73.
2002: Wahrle Suzanne; Das Pritam; Nyborg Andrew C; McLendon Chris; Shoji Mikio; Kawarabayashi Takeshi; Younkin Linda H; Younkin Steven G; Golde Todd E
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.
Neurobiology of disease 2002;9(1):11-23.
2002: Tang-Wai D; Lewis P; Boeve Bradley; Hutton M; Golde T; Baker M; Hardy J; Michels V; Ivnik R; Jack C; Petersen R
Familial frontotemporal dementia associated with a novel presenilin-1 mutation.
Dementia and geriatric cognitive disorders 2002;14(1):13-21.
2001: McPhie D L; Golde T; Eckman C B; Yager D; Brant J B; Neve R L
beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
Brain research. Molecular brain research 2001;97(1):103-13.
2001: Ni C Y; Murphy M P; Golde T E; Carpenter G
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase.
Science (New York, N.Y.) 2001;294(5549):2179-81.
2001: Weggen S; Eriksen J L; Das P; Sagi S A; Wang R; Pietrzik C U; Findlay K A; Smith T E; Murphy M P; Bulter T; Kang D E; Marquez-Sterling N; Golde T E; Koo E H
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
Nature 2001;414(6860):212-6.
2001: Palacino J J; Murphy M P; Murayama O; Iwasaki K; Fujiwara M; Takashima A; Golde T E; Wolozin B
Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion.
The Journal of biological chemistry 2001;276(42):38563-9.
2001: Das P; Murphy M P; Younkin L H; Younkin S G; Golde T E
Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
Neurobiology of aging 2001;22(5):721-7.
2001: Haugabook S J; Yager D M; Eckman E A; Golde T E; Younkin S G; Eckman C B
High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta).
Journal of neuroscience methods 2001;108(2):171-9.
2001: Lewis P A; Piper S; Baker M; Onstead L; Murphy M P; Hardy J; Wang R; McGowan E; Golde T E
Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides.
Biochimica et biophysica acta 2001;1537(1):58-62.
2001: Mudher A; Chapman S; Richardson J; Asuni A; Gibb G; Pollard C; Killick R; Iqbal T; Raymond L; Varndell I; Sheppard P; Makoff A; Gower E; Soden P E; Lewis P; Murphy M; Golde T E; Rupniak H T; Anderton B H; Lovestone S
Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):4987-95.
2001: Golde T E; Younkin S G
Presenilins as therapeutic targets for the treatment of Alzheimer's disease.
Trends in molecular medicine 2001;7(6):264-9.
2001: Haugabook S J; Le T; Yager D; Zenk B; Healy B M; Eckman E A; Prada C; Younkin L; Murphy P; Pinnix I; Onstead L; Sambamurti K; Golde T E; Dickson D; Younkin S G; Eckman C B
Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):16-18.
2001: Pinnix I; Musunuru U; Tun H; Sridharan A; Golde T; Eckman C; Ziani-Cherif C; Onstead L; Sambamurti K
A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.
The Journal of biological chemistry 2001;276(1):481-7.
2000: McLendon C; Xin T; Ziani-Cherif C; Murphy M P; Findlay K A; Lewis P A; Pinnix I; Sambamurti K; Wang R; Fauq A; Golde T E
Cell-free assays for gamma-secretase activity.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2383-6.
2000: Houlden H; Baker M; McGowan E; Lewis P; Hutton M; Crook R; Wood N W; Kumar-Singh S; Geddes J; Swash M; Scaravilli F; Holton J L; Lashley T; Tomita T; Hashimoto T; Verkkoniemi A; Kalimo H; Somer M; Paetau A; Martin J J; Van Broeckhoven C; Golde T; Hardy J; Haltia M; Revesz T
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
Annals of neurology 2000;48(5):806-8.
2000: Lewis P A; Perez-Tur J; Golde T E; Hardy J
The presenilin 1 C92S mutation increases abeta 42 production.
Biochemical and biophysical research communications 2000;277(1):261-3.
2000: Murphy M P; Uljon S N; Fraser P E; Fauq A; Lookingbill H A; Findlay K A; Smith T E; Lewis P A; McLendon D C; Wang R; Golde T E
Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.
The Journal of biological chemistry 2000;275(34):26277-84.
2000: Golde T E; Eckman C B; Younkin S G
Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease.
Biochimica et biophysica acta 2000;1502(1):172-87.
2000: Murphy M P; Wang R; Fraser P E; Fauq A; Golde T E
An empirical model of gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():233-40.
1999: Rennert H; Golde T; Wilson R B; Spitalnik S L; Van Deerlin V M; Leonard D G
A novel, non-nested reverse-transcriptase polymerase chain reaction (RT-PCR) test for the detection of the t(15;17) translocation: a comparative study of RT-PCR cytogenetics, and fluorescence In situ hybridization.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 1999;4(3):195-209.
1999: Murphy M P; Hickman L J; Eckman C B; Uljon S N; Wang R; Golde T E
gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length.
The Journal of biological chemistry 1999;274(17):11914-23.
1996: Cook D G; Sung J C; Golde T E; Felsenstein K M; Wojczyk B S; Tanzi R E; Trojanowski J Q; Lee V M; Doms R W
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9223-8.
1994: Nakamura T; Shoji M; Harigaya Y; Watanabe M; Hosoda K; Cheung T T; Shaffer L M; Golde T E; Younkin L H; Younkin S G
Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease.
Annals of neurology 1994;36(6):903-11.
1994: Suzuki N; Cheung T T; Cai X D; Odaka A; Otvos L; Eckman C; Golde T E; Younkin S G
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.
Science (New York, N.Y.) 1994;264(5163):1336-40.
1993: Wertkin A M; Turner R S; Pleasure S J; Golde T E; Younkin S G; Trojanowski J Q; Lee V M
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9513-7.
1993: Kalaria R N; Golde T; Kroon S N; Perry G
Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease.
The American journal of pathology 1993;143(3):886-93.
1993: Golde T E; Cai X D; Shoji M; Younkin S G
Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():103-8.
1993: Cai X D; Golde T E; Younkin S G
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.
Science (New York, N.Y.) 1993;259(5094):514-6.
1992: Estus S; Golde T E; Younkin S G
Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives.
Annals of the New York Academy of Sciences 1992;674():138-48.
1992: Shoji M; Golde T E; Ghiso J; Cheung T T; Estus S; Shaffer L M; Cai X D; McKay D M; Tintner R; Frangione B
Production of the Alzheimer amyloid beta protein by normal proteolytic processing.
Science (New York, N.Y.) 1992;258(5079):126-9.
1992: Gillespie S L; Golde T E; Younkin S G
Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation.
Biochemical and biophysical research communications 1992;187(3):1285-90.
1992: Golde T E; Estus S; Younkin L H; Selkoe D J; Younkin S G
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
Science (New York, N.Y.) 1992;255(5045):728-30.
1992: Estus S; Golde T E; Kunishita T; Blades D; Lowery D; Eisen M; Usiak M; Qu X M; Tabira T; Greenberg B D
Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.
Science (New York, N.Y.) 1992;255(5045):726-8.
1991: Kalaria R N; Golde T E; Cohen M L; Younkin S G
Serum amyloid P in Alzheimer's disease. Implications for dysfunction of the blood-brain barrier.
Annals of the New York Academy of Sciences 1991;640():145-8.
1990: Golde T E; Estus S; Usiak M; Younkin L H; Younkin S G
Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.
Neuron 1990;4(2):253-67.
1990: Palmert M R; Podlisny M B; Golde T E; Cohen M L; Kovacs D M; Tanzi R E; Gusella J F; Whitehouse P J; Witker D S; Oltersdorf T
Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products.
Advances in neurology 1990;51():181-4.
1989: Palmert M R; Podlisny M B; Golde T E; Cohen M L; Kovacs D M; Tanzi R E; Gusella J F; Whitehouse P J; Witker D S; Oltersdorf T
The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives.
Progress in clinical and biological research 1989;317():971-84.
1988: Osborne B A; Golde T E; Schwartz R L; Rudikoff S
Evolution of the IgA heavy chain gene in the genus Mus.
Genetics 1988;119(4):925-31.
1988: Palmert M R; Golde T E; Cohen M L; Kovacs D M; Tanzi R E; Gusella J F; Usiak M F; Younkin L H; Younkin S G
Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease.
Science (New York, N.Y.) 1988;241(4869):1080-4.
1988: Cohen M L; Golde T E; Usiak M F; Younkin L H; Younkin S G
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1227-31.
1986: Osborne B A; Golde T E; Schwartz R L; Rudikoff S
Evolution of the mouse IgA gene: nucleotide sequence comparison of IgA in BALB/c and Mus pahari.
Current topics in microbiology and immunology 1986;127():141-8.

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