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Ira Goldfine

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Eusebio Chiefari; Vincent Durlach; Daniela Foti; Ira D Goldfine; Manfredi Greco; Ugur Hodoglugil; Stefania Iiritano; Raffaele Maio; Aurora Nocera; Maria Pavia; Francesco Perticone; Katiuscia Possidente; Clive R Pullinger; Angela Sciacqua; Sinan Tanyolaç; Valeria Ventura; Raffaella Vero; Biagio Arcidiacono; francesco baudi; Francesco S Brunetti; Giuseppe Brunetti; C Capula; Antonio Brunetti
A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components.
Umesh Masharani; Shelley McCoy; Christine Gjerde; Ira D Goldfine; Danielle Hessler; Betty A Maddux; Jack F Youngren
Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.
Eusebio Chiefari; Sinan Tanyolaç; Francesco Paonessa; Clive R Pullinger; C Capula; Stefania Iiritano; Tommaso Mazza; Michele Forlin; Alfredo Fusco; Vincent Durlach; Anne Durlach; Mary J Malloy; John P Kane; Steven W Heiner; Mirella Filocamo; Daniela Foti; Ira D Goldfine; Antonio Brunetti
Functional variants of the HMGA1 gene and type 2 diabetes mellitus.

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2013: Eusebio Chiefari; Vincent Durlach; Daniela Foti; Ira D Goldfine; Manfredi Greco; Ugur Hodoglugil; Stefania Iiritano; Raffaele Maio; Aurora Nocera; Maria Pavia; Francesco Perticone; Katiuscia Possidente; Clive R Pullinger; Angela Sciacqua; Sinan Tanyolaç; Valeria Ventura; Raffaella Vero; Biagio Arcidiacono; francesco baudi; Francesco S Brunetti; Giuseppe Brunetti; C Capula; Antonio Brunetti
A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components.
Scientific reports 2013;3():1491.
2012: Umesh Masharani; Shelley McCoy; Christine Gjerde; Ira D Goldfine; Danielle Hessler; Betty A Maddux; Jack F Youngren
Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.
BMC endocrine disorders 2012;12():31.
2011: Eusebio Chiefari; Sinan Tanyolaç; Francesco Paonessa; Clive R Pullinger; C Capula; Stefania Iiritano; Tommaso Mazza; Michele Forlin; Alfredo Fusco; Vincent Durlach; Anne Durlach; Mary J Malloy; John P Kane; Steven W Heiner; Mirella Filocamo; Daniela Foti; Ira D Goldfine; Antonio Brunetti
Functional variants of the HMGA1 gene and type 2 diabetes mellitus.
JAMA : the journal of the American Medical Association 2011;305(9):903-12.
2011: Umesh B Masharani; Betty A Maddux; Xiaojuan Li; Giorgos K Sakkas; Kathleen Mulligan; Morris Schambelan; Ira D Goldfine; Jack F Youngren
Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.
PloS one 2011;6(5):e19878.
2010: Umesh Masharani; Christine Gjerde; Joseph L Evans; Jack F Youngren; Ira D Goldfine
Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome.
Journal of diabetes science and technology 2010;4(2):359-64.
2009: Sinan Tanyolaç; Andrew Bremer; Ugur Hodoglugil; Irina Movsesyan; Clive R Pullinger; Steven W Heiner; Mary J Malloy; John P Kane; Ira D Goldfine
Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects.
Metabolic syndrome and related disorders 2009;7(6):543-8.
2009: Umesh Masharani; Ira D Goldfine; Jack F Youngren
Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects.
Metabolism: clinical and experimental 2009;58(11):1602-8.
2008: Sinan Tanyolaç; Robert W Mahley; Ugur Hodoglugil; Ira D Goldfine
Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.
Obesity (Silver Spring, Md.) 2008;16(11):2468-71.
2008: Robert T Lum; Mingshan Cheng; Cristina P Cristobal; Ira D Goldfine; Joseph L Evans; James G Keck; Robert W Macsata; Vara Prasad Manchem; Yukiharu Matsumoto; Sophia J Park; Sandhya S Rao; Louise Robinson; Songyuan Shi; Wayne R Spevak; Steven R Schow
Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.
Journal of medicinal chemistry 2008;51(19):6173-87.
2008: Charles J Ryan; Marianna Zavodovskaya; Jack F Youngren; Michael Campbell; Marc Diamond; Jeremy Jones; Laura Shiry; Geoffrey Allan; Betty A Maddux; Ira D Goldfine
Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.
The Prostate 2008;68(11):1232-40.
2008: Charles J Ryan; Andrea H Harzstark; Jonathan Rosenberg; Amy Lin; Christina Claros; Ira D Goldfine; John F Kerner; Eric J Small; Jack F Youngren
A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer.
BJU international 2008;101(4):436-9.
2008: Ira D Goldfine; Betty A Maddux; Jack F Youngren; Gerald Reaven; Domenico Accili; Vincenzo Trischitta; Riccardo Vigneri; Lucia Frittitta
The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.
Endocrine reviews 2008;29(1):62-75.
2008: Xiaojuan Li; Jack F Youngren; Ben Hyun; Giorgos K Sakkas; Kathleen Mulligan; Sharmila Majumdar; Umesh B Masharani; Morris Schambelan; Ira D Goldfine
Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T.
Magnetic resonance imaging 2008;26(2):188-97.
2008: Marianna Zavodovskaya; Michael J Campbell; Betty A Maddux; Laura Shiry; Geoffrey Allan; Leslie Hodges; Peter Kushner; John A Kerner; Jack F Youngren; Ira D Goldfine
Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.
Journal of cellular biochemistry 2008;103(2):624-35.
2008: Cesar A Albarracin; Burcham C Fuqua; Joseph L Evans; Ira D Goldfine
Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes.
Diabetes/metabolism research and reviews 2008;24(1):41-51.
2007: Gary E Meyer; Louis Chesler; Dandan Liu; Karissa L Gable; Betty A Maddux; David D Goldenberg; Jack F Youngren; Ira D Goldfine; William A Weiss; Katherine K Matthay; Stephen M Rosenthal
Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
Journal of cellular biochemistry 2007;102(6):1529-41.
2007: Charles J Ryan; Christopher Haqq; Jeff Simko; Daisuke F Nonaka; June M Chan; Vivian Weinberg; Eric J Small; Ira D Goldfine
Expression of insulin-like growth factor-1 receptor in local and metastatic prostate cancer.
Urologic oncology 2007;25(2):134-40.
2006: Marc O Anderson; Hong Yu; Cristina Penaranda; Betty A Maddux; Ira D Goldfine; Jack F Youngren; R Kiplin Guy
Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.
Journal of combinatorial chemistry 2006;8(5):784-90.
2006: Betty A Maddux; Adelene Chan; Elena A De Filippis; Lawrence J. Manderino; Ira D Goldfine
IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance.
Diabetes care 2006;29(7):1535-7.
2006: Karissa L Gable; Betty A Maddux; Cristina Penaranda; Marianna Zavodovskaya; Michael J Campbell; Margaret Lobo; Louise Robinson; Steven Schow; John A Kerner; Ira D Goldfine; Jack F Youngren
Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.
Molecular cancer therapeutics 2006;5(4):1079-86.
2006: Betty A Maddux; Yow-Ning Chang; Domenico Accili; Owen P McGuinness; Jack F Youngren; Ira D Goldfine
Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.
American journal of physiology. Endocrinology and metabolism 2006;290(4):E746-9.
2005: Jack F Youngren; Karissa L Gable; Cristina Penaranda; Betty A Maddux; Marianna Zavodovskaya; Margaret Lobo; Michael Campbell; John Kerner; Ira D Goldfine
Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.
Breast cancer research and treatment 2005;94(1):37-46.
2005: Joseph L Evans; Jack J Lin; Ira D Goldfine
Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta.
Current diabetes reviews 2005;1(3):299-307.
2005: David Meyre; Nabila Bouatia-Naji; Agnès Tounian; Chantal Samson; Cécile Lecoeur; Vincent Vatin; Maya Ghoussaini; Christophe Wachter; Serge Hercberg; Guillaume Charpentier; Wolfgang Patsch; François Pattou; Marie-Aline Charles; Patrick Tounian; Karine Clément; Béatrice Jouret; Jacques Weill; Betty A Maddux; Ira D Goldfine; Andrew J Walley; Philippe Boutin; Christian Dina; philippe froguel
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
Nature genetics 2005;37(8):863-7.
2005: Joseph L Evans; Betty A Maddux; Ira D Goldfine
The molecular basis for oxidative stress-induced insulin resistance.
Antioxidants & redox signaling 2005;7(7-8):1040-52.
2005: Stephen Rothman; Hsien Tseng; Ira D Goldfine
Oral gene therapy: a novel method for the manufacture and delivery of protein drugs.
Diabetes technology & therapeutics 2005;7(3):549-57.
2005: Celia Pender; Ira D Goldfine; Jennifer L Kulp; Charles J Tanner; Betty A Maddux; Kenneth G MacDonald; Joseph A Houmard; Jack F Youngren
Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects.
Metabolism: clinical and experimental 2005;54(5):598-603.
2005: Hengjiang Dong; Betty A Maddux; Jennifer Altomonte; Marcia Meseck; Domenico Accili; Robert Terkeltaub; Kristen Johnson; Jack F Youngren; Ira D Goldfine
Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.
Diabetes 2005;54(2):367-72.
2004: Joseph L Evans; Jack F Youngren; Ira D Goldfine
Effective treatments for insulin resistance: trim the fat and douse the fire.
Trends in endocrinology and metabolism: TEM 2004;15(9):425-31.
2004: Mingshan Cheng; Seiyu Chen; Steven R Schow; Vara Prasad Manchem; Wayne R Spevak; Cristina P Cristobal; Songyuan Shi; Robert W Macsata; Robert T Lum; Ira D Goldfine; James G Keck
In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.
Journal of cellular biochemistry 2004;92(6):1234-45.
2004: Christopher Tan; Lianhu Wei; F Peter Ottensmeyer; Ira D Goldfine; Betty A Maddux; Cecil C Yip; Robert A Batey; Lakshmi P Kotra
Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor.
Bioorganic & medicinal chemistry letters 2004;14(6):1407-10.
2004: Celia Pender; Ira D Goldfine; Charles J Tanner; Walter J Pories; Kenneth G MacDonald; Peter J Havel; Joseph A Houmard; Jack F Youngren
Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(3):363-9.
2003: Francesco Frasca; Giuseppe Pandini; Riccardo Vigneri; Ira D Goldfine
Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells.
Breast disease 2003;17():73-89.
2003: Karen E Earle; Robert J Rushakoff; Ira D Goldfine
Inadvertent sulfonylurea overdosage and hypoglycemia in an elderly woman: failure of serum hypoglycemia screening.
Diabetes technology & therapeutics 2003;5(3):449-51.
2003: Joseph L Evans; Ira D Goldfine; Betty A Maddux; Gerold M Grodsky
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
Diabetes 2003;52(1):1-8.
2002: Celia Pender; Ira D Goldfine; Vara Prasad Manchem; Joseph L Evans; Wayne R Spevak; Songyuan Shi; Sandhya Rao; Sonia Bajjalieh; Betty A Maddux; Jack F Youngren
Regulation of insulin receptor function by a small molecule insulin receptor activator.
The Journal of biological chemistry 2002;277(46):43565-71.
2002: Joseph L Evans; Ira D Goldfine; Betty A Maddux; Gerold M Grodsky
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.
Endocrine reviews 2002;23(5):599-622.
2002: Ming Li; Jack F Youngren; Andrea Dunaif; Ira D Goldfine; Betty A Maddux; Bei B Zhang; Joseph L Evans
Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.
The Journal of clinical endocrinology and metabolism 2002;87(9):4088-93.
2002: Celia Pender; Heidi K Ortmeyer; Barbara C Hansen; Ira D Goldfine; Jack F Youngren
Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys.
Metabolism: clinical and experimental 2002;51(4):465-70.
2002: Joseph L Evans; Catherine J Heymann; Ira D Goldfine; Laurence A Gavin
Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2002;8(1):29-35.
2001: M Li; Jack F Youngren; Vara Prasad Manchem; M Kozlowski; Bei B Zhang; Betty A Maddux; Ira D Goldfine
Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.
Diabetes 2001;50(10):2323-8.
2001: Vara Prasad Manchem; Ira D Goldfine; R A Kohanski; C P Cristobal; Robert T Lum; Steven R Schow; Songyuan Shi; Wayne R Spevak; Edgardo Laborde; D K Toavs; Hugo Villar; Michael M Wick; M R Kozlowski
A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo.
Diabetes 2001;50(4):824-30.
2001: Jack F Youngren; S Keen; J L Kulp; Charles J Tanner; Joseph A Houmard; Ira D Goldfine
Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training.
American journal of physiology. Endocrinology and metabolism 2001;280(3):E528-33.
2001: Betty A Maddux; W See; J C Lawrence; A L Goldfine; Ira D Goldfine; Joseph L Evans
Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.
Diabetes 2001;50(2):404-10.
2001: Frank Rutsch; Sucheta M Vaingankar; Kristen Johnson; Ira D Goldfine; Betty A Maddux; P Schauerte; Hermann Kalhoff; K Sano; William A Boisvert; andrea superti-furga; Robert Terkeltaub
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.
The American journal of pathology 2001;158(2):543-54.
2000: Joseph L Evans; Ira D Goldfine
Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes.
Diabetes technology & therapeutics 2000;2(3):401-13.
2000: Betty A Maddux; Ira D Goldfine
Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.
Diabetes 2000;49(1):13-9.
1999: Ira D Goldfine; Betty A Maddux; Jack F Youngren; Vincenzo Trischitta; Lucia Frittitta
Role of PC-1 in the etiology of insulin resistance.
Annals of the New York Academy of Sciences 1999;892():204-22.
1999: Antonio Pizzuti; Lucia Frittitta; Alessandra Argiolas; Roberto Baratta; Ira D Goldfine; Maura Bozzali; Tonino Ercolino; G Scarlato; Licia Iacoviello; Riccardo Vigneri; Vittorio Tassi; Vincenzo Trischitta
A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.
Diabetes 1999;48(9):1881-4.
1999: Giuseppe Pandini; Riccardo Vigneri; Angela Costantino; Francesco Frasca; Antonio M Ippolito; Yoko Fujita-Yamaguchi; Kenneth Siddle; Ira D Goldfine; Antonino Belfiore
Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1935-44.
1999: Jack F Youngren; Ira D Goldfine; Richard E Pratley
Insulin receptor autophosphorylation in cultured myoblasts correlates to glucose disposal in Pima Indians.
The American journal of physiology 1999;276(5 Pt 1):E990-4.
1999: Francesco Frasca; Giuseppe Pandini; Pierluigi Scalia; Laura Sciacca; Rossana Mineo; Angela Costantino; Ira D Goldfine; Antonino Belfiore; Riccardo Vigneri
Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.
Molecular and cellular biology 1999;19(5):3278-88.
1999: Laura Sciacca; Angela Costantino; Giuseppe Pandini; Rossana Mineo; Francesco Frasca; Pierluigi Scalia; Paolo Sbraccia; Ira D Goldfine; Riccardo Vigneri; Antonino Belfiore
Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism.
Oncogene 1999;18(15):2471-9.
1998: B Gliozzo; Chin K Sung; Pierluigi Scalia; Vincenzo Papa; Francesco Frasca; Laura Sciacca; F Giorgino; Giovanni Milazzo; Ira D Goldfine; Riccardo Vigneri; Vincenzo Pezzino
Insulin-stimulated cell growth in insulin receptor substrate-1-deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3-kinase-independent pathway.
Journal of cellular biochemistry 1998;70(2):268-80.
1998: Lucia Frittitta; Daniela Spampinato; Anna Solini; Romano Nosadini; Ira D Goldfine; Riccardo Vigneri; Vincenzo Trischitta
Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling.
Diabetes 1998;47(7):1095-100.
1998: Ira D Goldfine; Betty A Maddux; Jack F Youngren; Lucia Frittitta; Vincenzo Trischitta; G Lynis Dohm
Membrane glycoprotein PC-1 and insulin resistance.
Molecular and cellular biochemistry 1998;182(1-2):177-84.
1998: Ira D Goldfine; Jack F Youngren
Contributions of the American Journal of Physiology to the discovery of insulin.
The American journal of physiology 1998;274(2 Pt 1):E207-9.
1997: M C Mathieu; G M Clark; D C Allred; Ira D Goldfine; R Vigneri
Insulin receptor expression and clinical outcome in node-negative breast cancer.
Proceedings of the Association of American Physicians 1997;109(6):565-71.
1997: Vincenzo Papa; Giovanni Milazzo; Ira D Goldfine; F M Waldman; Riccardo Vigneri
Sporadic amplification of the insulin receptor gene in human breast cancer.
Journal of endocrinological investigation 1997;20(9):531-6.
1997: Lucia Frittitta; aniello Cerrato; M G Sacco; N Weidner; Ira D Goldfine; Riccardo Vigneri
The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice.
Breast cancer research and treatment 1997;45(2):141-7.
1997: Jack F Youngren; Ira D Goldfine; Richard E Pratley
Decreased muscle insulin receptor kinase correlates with insulin resistance in normoglycemic Pima Indians.
The American journal of physiology 1997;273(2 Pt 1):E276-83.
1997: Lucia Frittitta; Jack F Youngren; Paolo Sbraccia; Monica D'Adamo; Angela Maria Buongiorno; Riccardo Vigneri; Ira D Goldfine; Vincenzo Trischitta
Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity.
Diabetologia 1997;40(3):282-9.
1997: Giovanni Milazzo; Laura Sciacca; Vincenzo Papa; Ira D Goldfine; Riccardo Vigneri
ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-I receptor.
Molecular carcinogenesis 1997;18(1):19-25.
1996: B Ozel; J F Youngren; J K Kim; Ira D Goldfine; Chin K Sung; Jang H Youn
The development of insulin resistance with high fat feeding in rats does not involve either decreased insulin receptor tyrosine kinase activity or membrane glycoprotein PC-1.
Biochemical and molecular medicine 1996;59(2):174-81.
1996: Antonino Belfiore; Angela Costantino; Francesco Frasca; Giuseppe Pandini; Rossana Mineo; P Vigneri; Betty A Maddux; Ira D Goldfine; Riccardo Vigneri
Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1318-26.
1996: Lucia Frittitta; Jack F Youngren; Riccardo Vigneri; Betty A Maddux; Vincenzo Trischitta; Ira D Goldfine
PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity.
Diabetologia 1996;39(10):1190-5.
1996: Jack F Youngren; Betty A Maddux; S Sasson; Paolo Sbraccia; E B Tapscott; M S Swanson; G L Dohm; Ira D Goldfine
Skeletal muscle content of membrane glycoprotein PC-1 in obesity. Relationship to muscle glucose transport.
Diabetes 1996;45(10):1324-8.
1996: Antonino Belfiore; Lucia Frittitta; Angela Costantino; Francesco Frasca; Giuseppe Pandini; Laura Sciacca; Ira D Goldfine; Riccardo Vigneri
Insulin receptors in breast cancer.
Annals of the New York Academy of Sciences 1996;784():173-88.
1995: V Sánchez-Margalet; Ira D Goldfine; KE Truitt; John B Imboden; C K Sung
Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1.
Molecular endocrinology (Baltimore, Md.) 1995;9(4):435-42.
1995: L Frittitta; Riccardo Vigneri; M R Stampfer; Ira D Goldfine
Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype.
Journal of cellular biochemistry 1995;57(4):666-9.
1994: V Sanchez-Margálet; Ira D Goldfine; C J Vlahos; C K Sung
Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.
Biochemical and biophysical research communications 1994;204(2):446-52.
1994: Z Q Tong; E Jack; M Moule; Ira D Goldfine; Cecil C Yip
Rodent insulin receptors are immunologically different from other mammalian insulin receptors.
General and comparative endocrinology 1994;94(3):374-81.
1994: C K Sung; V Sánchez-Margalet; Ira D Goldfine
Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.
The Journal of biological chemistry 1994;269(17):12503-7.
1994: C K Sung; K Y Wong; Cecil C Yip; D M Hawley; Ira D Goldfine
Deletion of residues 485-599 from the human insulin receptor abolishes antireceptor antibody binding and influences tyrosine kinase activation.
Molecular endocrinology (Baltimore, Md.) 1994;8(3):315-24.
1993: Angela Costantino; Giovanni Milazzo; F Giorgino; P Russo; Ira D Goldfine; Riccardo Vigneri; Antonino Belfiore
Insulin-resistant MDA-MB231 human breast cancer cells contain a tyrosine kinase inhibiting activity.
Molecular endocrinology (Baltimore, Md.) 1993;7(12):1667-76.
1993: Vincenzo Papa; P Russo; B Gliozzo; Ira D Goldfine; Riccardo Vigneri; Vincenzo Pezzino
An intact and functional soluble form of the insulin receptor is secreted by cultured cells.
Endocrinology 1993;133(3):1369-76.
1993: Antonio Brunetti; D Foti; Ira D Goldfine
Identification of unique nuclear regulatory proteins for the insulin receptor gene, which appear during myocyte and adipocyte differentiation.
The Journal of clinical investigation 1993;92(3):1288-95.
1993: Vincenzo Papa; B Gliozzo; G M Clark; W L McGuire; D Moore; Yoko Fujita-Yamaguchi; Riccardo Vigneri; Ira D Goldfine; Vincenzo Pezzino
Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer.
Cancer research 1993;53(16):3736-40.
1993: Betty A Maddux; Paolo Sbraccia; G M Reaven; D E Moller; Ira D Goldfine
Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance.
The Journal of clinical endocrinology and metabolism 1993;77(1):73-9.
1993: R A Rushakoff; Ira D Goldfine; L J Beccaria; A Mathur; R J Brand; R A Liddle
Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia.
The Journal of clinical endocrinology and metabolism 1993;76(2):489-93.
1993: Lucia Frittitta; Riccardo Vigneri; Vincenzo Papa; Ira D Goldfine; G Grasso; Vincenzo Trischitta
Structural and functional studies of insulin receptors in human breast cancer.
Breast cancer research and treatment 1993;25(1):73-82.
1992: C K Sung; Ira D Goldfine
Phosphatidylinositol-3-kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex.
Biochemical and biophysical research communications 1992;189(2):1024-30.
1992: R Rafaeloff; C C Yip; Ira D Goldfine
Binding of mutant insulins to a mutated insulin receptor.
Biochemical and biophysical research communications 1992;188(1):318-22.
1992: Giovanni Milazzo; F Giorgino; G Damante; C Sung; M R Stampfer; Riccardo Vigneri; Ira D Goldfine; Antonino Belfiore
Insulin receptor expression and function in human breast cancer cell lines.
Cancer research 1992;52(14):3924-30.
1992: P A Goodman; Paolo Sbraccia; Antonio Brunetti; K Y Wong; J D Carter; S M Rosenthal; Ira D Goldfine
Growth factor receptor regulation in the Minn-1 leprechaun: defects in both insulin receptor and epidermal growth factor receptor gene expression.
Metabolism: clinical and experimental 1992;41(5):504-9.
1992: Vincenzo Pezzino; Vincenzo Papa; Angela Costantino; Lucia Frittitta; P Russo; Ira D Goldfine; Riccardo Vigneri
Identification and initial characterization of insulin receptor-like immunoreactivity in human plasma.
The Journal of clinical endocrinology and metabolism 1992;74(5):1116-21.
1992: Giovanni Milazzo; Cecil C Yip; Betty A Maddux; Riccardo Vigneri; Ira D Goldfine
High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.
The Journal of clinical investigation 1992;89(3):899-908.
1992: C K Sung; X L Han; Antonio Brunetti; Betty A Maddux; R Yamamoto-Honda; Ira D Goldfine
Regulation of biological functions by an insulin receptor monoclonal antibody in insulin receptor beta-subunit mutants.
Biochemistry 1992;31(1):168-74.
1992: Ira D Goldfine; P Pilch
Insulin secretion and action and diabetes mellitus.
Journal of cellular biochemistry 1992;48(1):1-2.
1992: Ira D Goldfine; Vincenzo Papa; Riccardo Vigneri; Pentti Siiteri; S Rosenthal
Progestin regulation of insulin and insulin-like growth factor I receptors in cultured human breast cancer cells.
Breast cancer research and treatment 1992;22(1):69-79.
1992: K K Hartmann; T G Baier; Vincenzo Papa; M Kronenwett; E J Brown; Ira D Goldfine; S M Rosenthal
A monoclonal antibody to the T-cell receptor increases IGF-I receptor content in normal T-lymphocytes: comparison with phytohemagglutinin.
Journal of cellular biochemistry 1992;48(1):81-5.
1992: P W Mamula; Ira D Goldfine
Cloning and characterization of the human insulin-like growth factor-I receptor gene 5'-flanking region.
DNA and cell biology 1992;11(1):43-50.
1991: R Rafaeloff; Betty A Maddux; Antonio Brunetti; Paolo Sbraccia; C K Sung; R Patel; D M Hawley; Ira D Goldfine
Transmembrane signalling by insulin via an insulin receptor mutated at tyrosines 1158, 1162, and 1163.
Biochemical and biophysical research communications 1991;179(2):912-8.
1991: Vincenzo Pezzino; Giovanni Milazzo; Lucia Frittitta; Riccardo Vigneri; O Ezaki; M Kasahara; T R LeBon; Ira D Goldfine; Yoko Fujita-Yamaguchi
Radioimmunoassay for human insulin-like growth factor-I receptor: applicability to breast carcinoma specimens and cell lines.
Metabolism: clinical and experimental 1991;40(8):861-5.
1991: Vincenzo Papa; K K Hartmann; S M Rosenthal; Betty A Maddux; Pentti Siiteri; Ira D Goldfine
Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II.
Molecular endocrinology (Baltimore, Md.) 1991;5(5):709-17.
1991: S M Rosenthal; E J Brown; Antonio Brunetti; Ira D Goldfine
Fibroblast growth factor inhibits insulin-like growth factor-II (IGF-II) gene expression and increases IGF-I receptor abundance in BC3H-1 muscle cells.
Molecular endocrinology (Baltimore, Md.) 1991;5(5):678-84.
1991: Betty A Maddux; Ira D Goldfine
Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation.
The Journal of biological chemistry 1991;266(11):6731-6.
1991: S M Rosenthal; Antonio Brunetti; E J Brown; P W Mamula; Ira D Goldfine
Regulation of insulin-like growth factor (IGF) I receptor expression during muscle cell differentiation. Potential autocrine role of IGF-II.
The Journal of clinical investigation 1991;87(4):1212-9.
1991: F Giorgino; Antonino Belfiore; Giovanni Milazzo; Angela Costantino; Betty A Maddux; J Whittaker; Ira D Goldfine; Riccardo Vigneri
Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype.
Molecular endocrinology (Baltimore, Md.) 1991;5(3):452-9.
1991: M Wendorf; Ira D Goldfine
Archaeology of NIDDM. Excavation of the "thrifty" genotype.
Diabetes 1991;40(2):161-5.
1991: Paolo Sbraccia; P A Goodman; Betty A Maddux; K Y Wong; Y D Chen; G M Reaven; Ira D Goldfine
Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patient with insulin resistance and NIDDM.
Diabetes 1991;40(2):295-9.
1991: Cecil C Yip; C Grunfeld; Ira D Goldfine
Identification and characterization of the ligand-binding domain of insulin receptor by use of an anti-peptide antiserum against amino acid sequence 241-251 of the alpha subunit.
Biochemistry 1991;30(3):695-701.
1990: Vincenzo Papa; C C Reese; Antonio Brunetti; Riccardo Vigneri; Pentti Siiteri; Ira D Goldfine
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells.
Cancer research 1990;50(24):7858-62.
1990: Vincenzo Papa; Vincenzo Pezzino; Angela Costantino; Antonino Belfiore; Dario Giuffrida; Lucia Frittitta; G B Vannelli; R Brand; Ira D Goldfine; Riccardo Vigneri
Elevated insulin receptor content in human breast cancer.
The Journal of clinical investigation 1990;86(5):1503-10.
1990: K K Hartmann; Vincenzo Papa; E J Brown; U Doerries; S M Rosenthal; Ira D Goldfine
A rapid and simple one step method for isolation of poly(A)+ RNA from cells in monolayer.
Endocrinology 1990;127(4):2038-40.
1990: T Liegler; J Alexander; P Cresswell; Ira D Goldfine; R S Goodenow
An analysis of insulin receptor expression and binding on MHC class I positive and negative human lymphoblastoid cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1788-93.
1990: Antonio Brunetti; Ira D Goldfine
Differential effects of fibroblast growth factor on insulin receptor and muscle specific protein gene expression in BC3H-1 myocytes.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):880-5.
1990: Antonio Brunetti; Ira D Goldfine
Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor.
The Journal of biological chemistry 1990;265(11):5960-3.
1990: Paolo Sbraccia; K Y Wong; Antonio Brunetti; R Rafaeloff; Vincenzo Trischitta; D M Hawley; Ira D Goldfine
Insulin down-regulates insulin receptor number and up-regulates insulin receptor affinity in cells expressing a tyrosine kinase-defective insulin receptor.
The Journal of biological chemistry 1990;265(9):4902-7.
1990: P W Mamula; A R McDonald; Antonio Brunetti; Y Okabayashi; K Y Wong; Betty A Maddux; Craig D Logsdon; Ira D Goldfine
Regulating insulin-receptor-gene expression by differentiation and hormones.
Diabetes care 1990;13(3):288-301.
1989: Judith L Treadway; B D Morrison; Ira D Goldfine; Jeffrey Pessin
Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro.
The Journal of biological chemistry 1989;264(36):21450-3.
1989: Antonio Brunetti; B A Maddux; K Y Wong; C Hofmann; J Whittaker; C Sung; Ira D Goldfine
Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected 3T3/HIR fibroblasts without activating receptor kinase.
Biochemical and biophysical research communications 1989;165(1):212-8.
1989: C K Sung; Betty A Maddux; D M Hawley; Ira D Goldfine
Monoclonal antibodies mimic insulin activation of ribosomal protein S6 kinase without activation of insulin receptor tyrosine kinase. Studies in cells transfected with normal and mutant human insulin receptors.
The Journal of biological chemistry 1989;264(32):18951-9.
1989: S L Amacher; L J Goodman; D A Bravo; K Y Wong; Ira D Goldfine; D M Hawley; Gary L Firestone
Glucocorticoid-regulated and constitutive trafficking of proteolytically processed cell surface-associated glycoproteins in wild type and variant rat hepatoma cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(10):1634-42.
1989: R Rafaeloff; R Patel; C Yip; Ira D Goldfine; D M Hawley
Mutation of the high cysteine region of the human insulin receptor alpha-subunit increases insulin receptor binding affinity and transmembrane signaling.
The Journal of biological chemistry 1989;264(27):15900-4.
1989: Vincenzo Pezzino; Vincenzo Papa; Vincenzo Trischitta; Antonio Brunetti; P A Goodman; M K Treutelaar; John Williams; Betty A Maddux; Riccardo Vigneri; Ira D Goldfine
Human insulin receptor radioimmunoassay: applicability to insulin-resistant states.
The American journal of physiology 1989;257(3 Pt 1):E451-7.
1989: D M Hawley; Betty A Maddux; R G Patel; K Y Wong; P W Mamula; Gary L Firestone; Antonio Brunetti; E Verspohl; Ira D Goldfine
Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase.
The Journal of biological chemistry 1989;264(5):2438-44.
1989: Y Okabayashi; Betty A Maddux; A R McDonald; Craig D Logsdon; John Williams; Ira D Goldfine
Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels.
Diabetes 1989;38(2):182-7.
1989: Antonio Brunetti; Betty A Maddux; K Y Wong; Ira D Goldfine
Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels.
The Journal of clinical investigation 1989;83(1):192-8.
1988: Cecil C Yip; H Hsu; R G Patel; D M Hawley; Betty A Maddux; Ira D Goldfine
Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunit.
Biochemical and biophysical research communications 1988;157(1):321-9.
1988: P W Mamula; K Y Wong; Betty A Maddux; A R McDonald; Ira D Goldfine
Sequence and analysis of promoter region of human insulin-receptor gene.
Diabetes 1988;37(9):1241-6.
1988: E J Verspohl; Betty A Maddux; Ira D Goldfine
Insulin and insulin-like growth factor I regulate the same biological functions in HEP-G2 cells via their own specific receptors.
The Journal of clinical endocrinology and metabolism 1988;67(1):169-74.
1988: R A Liddle; R J Rushakoff; E T Morita; L Beccaria; J D Carter; Ira D Goldfine
Physiological role for cholecystokinin in reducing postprandial hyperglycemia in humans.
The Journal of clinical investigation 1988;81(6):1675-81.
1988: Francesco Purrello; Damiano Gullo; M Buscema; Vincenzo Pezzino; Riccardo Vigneri; Ira D Goldfine
Metformin enhances certain insulin actions in cultured rat hepatoma cells.
Diabetologia 1988;31(6):385-9.
1988: Stefan Rosewicz; A R McDonald; Betty A Maddux; Ira D Goldfine; R L Miesfeld; Craig D Logsdon
Mechanism of glucocorticoid receptor down-regulation by glucocorticoids.
The Journal of biological chemistry 1988;263(6):2581-4.
1988: A R McDonald; Ira D Goldfine
Glucocorticoid regulation of insulin receptor gene transcription in IM-9 cultured lymphocytes.
The Journal of clinical investigation 1988;81(2):499-504.
1988: K Y Wong; D Hawley; R Vigneri; Ira D Goldfine
Comparison of solubilized and purified plasma membrane and nuclear insulin receptors.
Biochemistry 1988;27(1):375-9.
1987: R J Rushakoff; Ira D Goldfine; J D Carter; R A Liddle
Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans.
The Journal of clinical endocrinology and metabolism 1987;65(3):395-401.
1987: Francesco Purrello; Damiano Gullo; Antonio Brunetti; M Buscema; S Italia; Ira D Goldfine; Riccardo Vigneri
Direct effects of biguanides on glucose utilization in vitro.
Metabolism: clinical and experimental 1987;36(8):774-6.
1987: Ira D Goldfine
The insulin receptor: molecular biology and transmembrane signaling.
Endocrine reviews 1987;8(3):235-55.
1987: A R McDonald; Betty A Maddux; Y Okabayashi; K Y Wong; D M Hawley; Craig D Logsdon; Ira D Goldfine
Regulation of insulin-receptor mRNA levels by glucocorticoids.
Diabetes 1987;36(6):779-81.
1986: Vincenzo Trischitta; Damiano Gullo; S Squatrito; Vincenzo Pezzino; Ira D Goldfine; Riccardo Vigneri
Insulin internalization into monocytes is decreased in patients with type II diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1986;62(3):522-8.
1983: R A Roth; B A Maddux; D J Cassell; Ira D Goldfine
Regulation of the insulin receptor by a monoclonal anti-receptor antibody. Evidence that receptor down regulation can be independent of insulin action.
The Journal of biological chemistry 1983;258(20):12094-7.
1983: R A Roth; D J Cassell; B A Maddux; Ira D Goldfine
Regulation of insulin receptor kinase activity by insulin mimickers and an insulin antagonist.
Biochemical and biophysical research communications 1983;115(1):245-52.
1982: R A Roth; D J Cassell; K Y Wong; B A Maddux; Ira D Goldfine
Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(23):7312-6.
1981: R A Roth; K Y Wong; B A Maddux; Ira D Goldfine
Production of antibodies that inhibit the binding of insulin to its receptor.
Biochemical and biophysical research communications 1981;101(3):979-87.
1981: R A Roth; B A Maddux; K Y Wong; Y Iwamoto; Ira D Goldfine
Insulin-ricin B chain conjugate. A hybrid molecule with ricin-binding activity and insulin biological activity.
The Journal of biological chemistry 1981;256(11):5350-4.