FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Bernard Golding

Research Profile

Concepts & Ideas

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Honorine Lebraud; Celine Cano; Benoit Carbain; Roger J Griffin; Ian R Hardcastle; Ross W Harrington; Bernard T Golding
Trifluoroethanol solvent facilitates selective N-7 methylation of purines.
Peter Friedrich; Ulrich Baisch; Wolfgang Buckel; Ross W Harrington; Fredrick Lyatuu; William McFarlane; Felix Zelder; Kai Zhou; Bernard T Golding
Experimental study of hydrogen bonding potentially stabilizing the 5'-deoxyadenosyl radical from coenzyme B12.
Tristan Reuillon; Annalisa Bertoli; Roger J Griffin; Duncan C Miller; Bernard T Golding
Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Bernard Golding (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Honorine Lebraud; Celine Cano; Benoit Carbain; Roger J Griffin; Ian R Hardcastle; Ross W Harrington; Bernard T Golding
Trifluoroethanol solvent facilitates selective N-7 methylation of purines.
Organic & biomolecular chemistry 2013;11(11):1874-8.
2012: Peter Friedrich; Ulrich Baisch; Wolfgang Buckel; Ross W Harrington; Fredrick Lyatuu; William McFarlane; Felix Zelder; Kai Zhou; Bernard T Golding
Experimental study of hydrogen bonding potentially stabilizing the 5'-deoxyadenosyl radical from coenzyme B12.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(50):16114-22.
2012: Tristan Reuillon; Annalisa Bertoli; Roger J Griffin; Duncan C Miller; Bernard T Golding
Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups.
Organic & biomolecular chemistry 2012;10(37):7610-7.
2012: Wolfgang Buckel; Peter Friedrich; Bernard T Golding
Hydrogen bonds guide the short-lived 5'-deoxyadenosyl radical to the place of action.
Angewandte Chemie (International ed. in English) 2012;51(40):9974-6.
2012: Kate M Clapham; Faye Craven; Bernard T Golding; Roger J Griffin; Karen Haggerty; Ian R Hardcastle; Gavin Jones; Tommy Rennison; Pia Thommes; Attilla Ting; Julia Bárdos; Céline Cano
Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.
Organic & biomolecular chemistry 2012;10(33):6747-57.
2011: Shilpa Bali; Stuart J Ferguson; Bernard T Golding; Mark J Howard; Andrew D Lawrence; Susana A Lobo; David J Palmer; Lígia M Saraiva; Martin J Warren
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(45):18260-5.
2011: Sonsoles Rodriguez-Aristegui; Lauren Barrett; Céline Cano; Kate M Clapham; Marine Desage-El Murr; Roger J Griffin; Ian R Hardcastle; Sara L Payne; Tommy Rennison; Caroline Richardson; Bernard T Golding
Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.
Organic & biomolecular chemistry 2011;9(17):6066-74.
2011: Petra Begemann; Gunnar Boysen; Nadia I Georgieva; Avram Gold; Bernard T Golding; Hasan Koc; Karl M Koshlap; Ramiah Sangaiah; Daping Zhang; James A Swenberg
Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.
Chemical research in toxicology 2011;24(7):1048-61.
2011: Kappusamy Saravanan; Hannah C Barlow; Marion Barton; A Hilary Calvert; Bernard T Golding; David R Newell; Julian S Northen; Nicola J Curtin; Huw D Thomas; Roger J Griffin
Nucleoside transport inhibitors: structure-activity relationships for pyrimido[5,4-d]pyrimidine derivatives that potentiate pemetrexed cytotoxicity in the presence of α1-acid glycoprotein.
Journal of medicinal chemistry 2011;54(6):1847-59.
2011: Ian R Hardcastle; Junfeng Liu; Eric Valeur; Anna Watson; Shafiq U Ahmed; Timothy J Blackburn; Karim Bennaceur; William Clegg; Catherine Drummond; Jane A Endicott; Bernard T Golding; Roger J Griffin; Jan Gruber; Karen Haggerty; Ross W Harrington; Claire Hutton; Stuart Kemp; Xiaohong Lu; James M McDonnell; David R Newell; Martin E M Noble; Sara L Payne; Charlotte H Revill; Christiane Riedinger; Qing Xu; John Lunec
Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.
Journal of medicinal chemistry 2011;54(5):1233-43.
2011: Kate M Clapham; Julia Bárdos; M Raymond V Finlay; Bernard T Golding; Edward J Griffen; Roger J Griffin; Ian R Hardcastle; Keith A Menear; Attilla Ting; Paul Turner; Gail L Young; Céline Cano
DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain.
Bioorganic & medicinal chemistry letters 2011;21(3):966-70.
2010: Céline Cano; Olivier R Barbeau; Christine Bailey; Xiao-Ling Cockcroft; Nicola J Curtin; Heather Duggan; Mark Frigerio; Bernard T Golding; Ian R Hardcastle; Marc G Hummersone; Charlotte Knights; Keith A Menear; David R Newell; Caroline J Richardson; Graeme C M Smith; Ben Spittle; Roger J Griffin
DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype.
Journal of medicinal chemistry 2010;53(24):8498-507.
2010: Sara L Payne; Sonsoles Rodriguez-Aristegui; Julia Bárdos; Céline Cano; Bernard T Golding; Ian R Hardcastle; Marcus Peacock; Nahida Parveen; Roger J Griffin
Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(12):3649-53.
2010: Christopher Wong; Roger J Griffin; Ian R Hardcastle; Julian S Northen; Lan Z Wang; Bernard T Golding
Synthesis of sulfonamide-based kinase inhibitors from sulfonates by exploiting the abrogated SN2 reactivity of 2,2,2-trifluoroethoxysulfonates.
Organic & biomolecular chemistry 2010;8(10):2457-64.
2010: Francesco Marchetti; Céline Cano; Nicola J Curtin; Bernard T Golding; Roger J Griffin; Karen Haggerty; David R Newell; Rachel J Parsons; Sara L Payne; Lan Z Wang; Ian R Hardcastle
Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors.
Organic & biomolecular chemistry 2010;8(10):2397-407.
2010: Céline Cano; Bernard T Golding; Karen Haggerty; Ian R Hardcastle; Marcus Peacock; Roger J Griffin
Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK).
Organic & biomolecular chemistry 2010;8(8):1922-8.
2009: Hitesh V Motwani; Charlotta Fred; Johanna Haglund; Bernard T Golding; Margareta Törnqvist
Cob(I)alamin for trapping butadiene epoxides in metabolism with rat S9 and for determining associated kinetic parameters.
Chemical research in toxicology 2009;22(9):1509-16.
2009: Huw D Thomas; Kappusamy Saravanan; Lan-Zhen Wang; Mei-Ju Lin; Julian S Northen; Hannah Barlow; Marion Barton; David R Newell; Roger J Griffin; Bernard T Golding; Nicola J Curtin
Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity.
Molecular cancer therapeutics 2009;8(7):1828-37.
2008: Christiane Riedinger; Jane A Endicott; Stuart J Kemp; Lynette A Smyth; Anna Watson; Eric Valeur; Bernard T Golding; Roger J Griffin; Ian R Hardcastle; Martin E M Noble; James M McDonnell
Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction.
Journal of the American Chemical Society 2008;130(47):16038-44.
2008: Antonio J Pierik; Torsten Graf; Louise Pemberton; Bernard T Golding; János Rétey
But-3-ene-1,2-diol: a mechanism-based active site inhibitor for coenzyme B12-dependent glycerol dehydratase.
Chembiochem : a European journal of chemical biology 2008;9(14):2268-75.
2008: Marine Desage-El Murr; Celine Cano; Bernard T Golding; Ian R Hardcastle; Marc Hummersome; Mark Frigerio; Nicola J Curtin; Keith A Menear; Caroline Richardson; Graeme C M Smith; Roger J Griffin
8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).
Bioorganic & medicinal chemistry letters 2008;18(17):4885-90.
2008: Peter Friedrich; Daniel Darley; Bernard T Golding; Wolfgang Buckel
The complete stereochemistry of the enzymatic dehydration of 4-hydroxybutyryl coenzyme A to crotonyl coenzyme A.
Angewandte Chemie (International ed. in English) 2008;47(17):3254-7.
2007: Olivier R Barbeau; Celine Cano-Soumillac; Roger J Griffin; Ian R Hardcastle; Graeme C M Smith; Caroline Richardson; William Clegg; Ross W Harrington; Bernard T Golding
Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase.
Organic & biomolecular chemistry 2007;5(16):2670-7.
2007: Francesco Marchetti; Kerry L Sayle; Johanne Bentley; William Clegg; Nicola J Curtin; Jane A Endicott; Bernard T Golding; Roger J Griffin; Karen Haggerty; Ross W Harrington; Veronique Mesguiche; David R Newell; Martin E M Noble; Rachel J Parsons; David J Pratt; Lan Z Wang; Ian R Hardcastle
Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2.
Organic & biomolecular chemistry 2007;5(10):1577-85.
2007: Jonathan J Hollick; Laurent Rigoreau; Celine Cano-Soumillac; Xiaoling Cockcroft; Nicola J Curtin; Mark Frigerio; Bernard T Golding; Sophie Guiard; Ian R Hardcastle; Ian Hickson; Marc G Hummersone; Keith A Menear; Niall M B Martin; Ian Matthews; David R Newell; Rachel Ord; Caroline J Richardson; Graeme C M Smith; Roger J Griffin
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Journal of medicinal chemistry 2007;50(8):1958-72.
2007: Tony Munter; Lisa Cottrell; Rikas Ghai; Bernard T Golding; William P Watson
The metabolism and molecular toxicology of chloroprene.
Chemico-biological interactions 2007;166(1-3):323-31.
2007: Sonja Seeberger; Roger J Griffin; Ian R Hardcastle; Bernard T Golding
A new strategy for the synthesis of taurine derivatives using the 'safety-catch' principle for the protection of sulfonic acids.
Organic & biomolecular chemistry 2007;5(1):132-8.
2006: Sonsoles Rodriguez Aristegui; Marine Desage El-Murr; Bernard T Golding; Roger J Griffin; Ian R Hardcastle
Judicious application of allyl protecting groups for the synthesis of 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl triflate, a key precursor of DNA-dependent protein kinase inhibitors.
Organic letters 2006;8(26):5927-9.
2006: Ian R Hardcastle; Shafiq U Ahmed; Helen Atkins; Gillian Farnie; Bernard T Golding; Roger J Griffin; Sabrina Guyenne; Claire Hutton; Per Kallblad; Stuart J Kemp; Martin S Kitching; David R Newell; Stefano Norbedo; Julian S Northen; Rebecca J Reid; K Saravanan; Henriëtte M G Willems; John Lunec
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.
Journal of medicinal chemistry 2006;49(21):6209-21.
2006: Roger J Griffin; Andrew Henderson; Nicola J Curtin; Aude Echalier; Jane A Endicott; Ian R Hardcastle; David R Newell; Martin E M Noble; Lan Z Wang; Bernard T Golding
Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination.
Journal of the American Chemical Society 2006;128(18):6012-3.
2006: Wolfgang Buckel; Bernard T Golding
Radical enzymes in anaerobes.
Annual review of microbiology 2006;60():27-49.
2005: Wolfgang Buckel; Christoph Kratky; Bernard T Golding
Stabilisation of methylene radicals by cob(II)alamin in coenzyme B12 dependent mutases.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;12(2):352-62.
2005: Ian R Hardcastle; Xiaoling Cockcroft; Nicola J Curtin; Marine Desage El-Murr; Justin J J Leahy; Martin Stockley; Bernard T Golding; Laurent Rigoreau; Caroline Richardson; Graeme C M Smith; Roger J Griffin
Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Journal of medicinal chemistry 2005;48(24):7829-46.
2005: Bernard P Nutley; Nicola F Smith; Angela Hayes; Lloyd R Kelland; Lisa Brunton; Bernard T Golding; G C M Smith; Niall M B Martin; Paul Workman; Florence I Raynaud
Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026.
British journal of cancer 2005;93(9):1011-8.
2005: Wolfgang Buckel; Berta M Martins; Albrecht Messerschmidt; Bernard T Golding
Radical-mediated dehydration reactions in anaerobic bacteria.
Biological chemistry 2005;386(10):951-9.
2005: Alistair P Henderson; Christine Bleasdale; Kirsty Delaney; Andrew B Lindstrom; Stephen M Rappaport; Suramya Waidyanatha; William P Watson; Bernard T Golding
Evidence for the formation of Michael adducts from reactions of (E,E)-muconaldehyde with glutathione and other thiols.
Bioorganic chemistry 2005;33(5):363-73.
2005: Marzia Pennati; Allyson J Campbell; Maria Curto; Mara Binda; Yuzhu Cheng; Lan Z Wang; Nicola J Curtin; Bernard T Golding; Roger J Griffin; Ian R Hardcastle; Andrew Henderson; Nadia Zaffaroni; David R Newell
Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
Molecular cancer therapeutics 2005;4(9):1328-37.
2005: Antonio J Pierik; Daniele Ciceri; Ruben Fernandez Lopez; Fritz Kroll; Gerd Bröker; Birgitta Beatrix; Wolfgang Buckel; Bernard T Golding
Searching for intermediates in the carbon skeleton rearrangement of 2-methyleneglutarate to (R)-3-methylitaconate catalyzed by coenzyme B12-dependent 2-methyleneglutarate mutase from Eubacterium barkeri.
Biochemistry 2005;44(31):10541-51.
2005: Ian R Hardcastle; Shafiq U Ahmed; Helen Atkins; A Hilary Calvert; Nicola J Curtin; Gillian Farnie; Bernard T Golding; Roger J Griffin; Sabrina Guyenne; Claire Hutton; Per Kallblad; Stuart J Kemp; Martin S Kitching; David R Newell; Stefano Norbedo; Julian S Northen; Rebecca J Reid; K Saravanan; Henriëtte M G Willems; John Lunec
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.
Bioorganic & medicinal chemistry letters 2005;15(5):1515-20.
2005: Rasmus Barfod; Jette Eriksen; Bernard T Golding; Anders Hammershøi; Thomas Amos Jacobsen; Annette Langkilde; Sine Larsen; Ole Mønsted; Alan M Sargeson; Henning Osholm Sørensen
Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates.
Dalton transactions (Cambridge, England : 2003) 2005;(3):491-500.
2005: Virginia Silvari; Johanna Haglund; Dag Jenssen; Bernard T Golding; Lars Ehrenberg; Margareta Törnqvist
Reaction-kinetic parameters of glycidamide as determinants of mutagenic potency.
Mutation research 2005;580(1-2):91-101.
2005: Birgit Paulsson; Agneta Rannug; Alistair P Henderson; Bernard T Golding; Margareta Törnqvist; Margareta Warholm
In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood.
Mutation research 2005;580(1-2):53-9.
2005: Alistair P Henderson; Martine L Barnes; Christine Bleasdale; Richard Cameron; William Clegg; Sarah L Heath; Andrew B Lindstrom; Stephen M Rappaport; Suramya Waidyanatha; William P Watson; Bernard T Golding
Reactions of benzene oxide with thiols including glutathione.
Chemical research in toxicology 2005;18(2):265-70.
2005: Ulrike Näser; Antonio J Pierik; Richard Scott; Irfan Cinkaya; Wolfgang Buckel; Bernard T Golding
Synthesis of (13)C-labeled gamma-hydroxybutyrates for EPR studies with 4-hydroxybutyryl-CoA dehydratase.
Bioorganic chemistry 2005;33(1):53-66.
2005: Roger J Griffin; Gabriele Fontana; Bernard T Golding; Sophie Guiard; Ian R Hardcastle; Justin J J Leahy; Niall Martin; Caroline Richardson; Laurent Rigoreau; Martin Stockley; Graeme C M Smith
Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Journal of medicinal chemistry 2005;48(2):569-85.
2004: Justin J J Leahy; Bernard T Golding; Roger J Griffin; Ian R Hardcastle; Caroline Richardson; Laurent Rigoreau; Graeme C M Smith
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
Bioorganic & medicinal chemistry letters 2004;14(24):6083-7.
2004: William P Watson; Tony Munter; Bernard T Golding
A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics.
Chemical research in toxicology 2004;17(12):1562-7.
2004: Jayashree G Tikhe; Stephen E Webber; Zdenek Hostomsky; Karen A Maegley; Anne Ekkers; Jianke Li; Xiao-Hong Yu; Robert Almassy; Robert A Kumpf; Theodore J Boritzki; Cathy Zhang; Christopher R Calabrese; Nicola J Curtin; Suzanne Kyle; Huw D Thomas; Lan-Zhen Wang; A Hilary Calvert; Bernard T Golding; Roger J Griffin; David R Newell
Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.
Journal of medicinal chemistry 2004;47(22):5467-81.
2004: Nicola J Curtin; Hannah C Barlow; Karen J Bowman; A Hilary Calvert; Richard Davison; Bernard T Golding; Bing Huang; Peter J Loughlin; David R Newell; Peter G Smith; Roger J Griffin
Resistance-modifying agents. 11.(1) Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to alpha1-acid glycoprotein.
Journal of medicinal chemistry 2004;47(20):4905-22.
2004: Ian R Hardcastle; Christine E Arris; Johanne Bentley; F Thomas Boyle; Yuzhu Chen; Nicola J Curtin; Jane A Endicott; Ashleigh E Gibson; Bernard T Golding; Roger J Griffin; Philip Jewsbury; Jerome Menyerol; Veronique Mesguiche; David R Newell; Martin E M Noble; David J Pratt; Lan Z Wang; Hayley J Whitfield
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
Journal of medicinal chemistry 2004;47(15):3710-22.
2004: Petra Begemann; Nadia I Christova-Georgieva; Ramiah Sangaiah; Hasan Koc; Daping Zhang; Bernard T Golding; Avram Gold; James A Swenberg
Synthesis, characterization, and identification of N7-guanine adducts of isoprene monoepoxides in vitro.
Chemical research in toxicology 2004;17(7):929-36.
2004: Richard Scott; Ulrike Näser; Peter Friedrich; Thorsten Selmer; Wolfgang Buckel; Bernard T Golding
Stereochemistry of hydrogen removal from the 'unactivated' C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase.
Chemical communications (Cambridge, England) 2004;(10):1210-1.
2004: Alex W White; Nicola J Curtin; Brian W Eastman; Bernard T Golding; Zdenek Hostomsky; Suzanne Kyle; Jianke Li; Karen A Maegley; Donald J Skalitzky; Stephen E Webber; Xiao-Hong Yu; Roger J Griffin
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(10):2433-7.
2004: Alistair P Henderson; Christine Bleasdale; William Clegg; Bernard T Golding
2,6-diarylaminotetrahydropyrans from reactions of glutaraldehyde with anilines: models for biomolecule cross-linking.
Chemical research in toxicology 2004;17(3):378-82.
2004: Charlotta Fred; T Cantillana; Alistair P Henderson; Bernard T Golding; Margareta Törnqvist
Adducts of N-terminal valines in hemoglobin with isoprene diepoxide, a metabolite of isoprene.
Rapid communications in mass spectrometry : RCM 2004;18(18):2177-84.
2003: Hayley J Whitfield; Roger J Griffin; Ian R Hardcastle; Andrew Henderson; Jerome Meneyrol; Veronique Mesguiche; Kerry L Sayle; Bernard T Golding
Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol.
Chemical communications (Cambridge, England) 2003;(22):2802-3.
2003: Tony Munter; Lisa Cottrell; Bernard T Golding; William P Watson
Detoxication pathways involving glutathione and epoxide hydrolase in the in vitro metabolism of chloroprene.
Chemical research in toxicology 2003;16(10):1287-97.
2003: Jonathan J Hollick; Bernard T Golding; Ian R Hardcastle; Niall Martin; Caroline Richardson; Laurent Rigoreau; Graeme C M Smith; Roger J Griffin
2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).
Bioorganic & medicinal chemistry letters 2003;13(18):3083-6.
2003: Kerry L Sayle; Johanne Bentley; F Thomas Boyle; A Hilary Calvert; Yuzhu Cheng; Nicola J Curtin; Jane A Endicott; Bernard T Golding; Ian R Hardcastle; Philip Jewsbury; Veronique Mesguiche; David R Newell; Martin E M Noble; Rachel J Parsons; David J Pratt; Lan Z Wang; Roger J Griffin
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.
Bioorganic & medicinal chemistry letters 2003;13(18):3079-82.
2003: Bernard T Golding; Lisa Cottrell; Daniel Mackay; Daping Zhang; William P Watson
Stereochemical and kinetic comparisons of mono- and diepoxide formation in the in vitro metabolism of isoprene by liver microsomes from rats, mice, and humans.
Chemical research in toxicology 2003;16(7):933-44.
2003: Raghuram Chetty; Paul A Christensen; Bernard T Golding
In situ FTIR studies on the electrochemical reduction of halogenated phenols.
Chemical communications (Cambridge, England) 2003;(8):984-5.
2003: Marc Hetzel; Matthias Brock; Thorsten Selmer; Antonio J Pierik; Bernard T Golding; Wolfgang Buckel
Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein.
European journal of biochemistry / FEBS 2003;270(5):902-10.
2003: Veronique Mesguiche; Rachel J Parsons; Christine E Arris; Johanne Bentley; F Thomas Boyle; Nicola J Curtin; Thomas G Davies; Jane A Endicott; Ashleigh E Gibson; Bernard T Golding; Roger J Griffin; Philip Jewsbury; Louise N Johnson; David R Newell; Martin E M Noble; Lan Z Wang; Ian R Hardcastle
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.
Bioorganic & medicinal chemistry letters 2003;13(2):217-22.
2003: Donald J Skalitzky; Joseph T Marakovits; Karen A Maegley; Anne Ekker; Xiao-Hong Yu; Zdenek Hostomsky; Stephen E Webber; Brian W Eastman; Robert Almassy; Jianke Li; Nicola J Curtin; David R Newell; A Hilary Calvert; Roger J Griffin; Bernard T Golding
Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.
Journal of medicinal chemistry 2003;46(2):210-3.
2002: Tony Munter; Lisa Cottrell; Stuart Hill; Leif Kronberg; William P Watson; Bernard T Golding
Identification of adducts derived from reactions of (1-chloroethenyl)oxirane with nucleosides and calf thymus DNA.
Chemical research in toxicology 2002;15(12):1549-60.
2002: Antonio J Pierik; Daniele Ciceri; Gerd Bröker; Christopher H Edwards; William McFarlane; Joachim Winter; Wolfgang Buckel; Bernard T Golding
Rotation of the exo-methylene group of (R)-3-methylitaconate catalyzed by coenzyme B(12)-dependent 2-methyleneglutarate mutase from Eubacterium barkeri.
Journal of the American Chemical Society 2002;124(47):14039-48.
2002: Stacie S Canan Koch; Lars H Thoresen; Jayashree G Tikhe; Karen A Maegley; Robert Almassy; Jianke Li; Xiao-Hong Yu; Scott E Zook; Robert A Kumpf; Cathy Zhang; Theodore J Boritzki; Rena N Mansour; Kanyin E Zhang; Anne Ekker; Christopher R Calabrese; Nicola J Curtin; Suzanne Kyle; Huw D Thomas; Lan-Zhen Wang; A Hilary Calvert; Bernard T Golding; Roger J Griffin; David R Newell; Stephen E Webber; Zdenek Hostomsky
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
Journal of medicinal chemistry 2002;45(23):4961-74.
2002: Thomas G Davies; Johanne Bentley; Christine E Arris; F Thomas Boyle; Nicola J Curtin; Jane A Endicott; Ashleigh E Gibson; Bernard T Golding; Roger J Griffin; Ian R Hardcastle; Philip Jewsbury; Louise N Johnson; Veronique Mesguiche; David R Newell; Martin E M Noble; Julie A Tucker; Lan Wang; Hayley J Whitfield
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor.
Nature structural biology 2002;9(10):745-9.
2002: Alistair P Henderson; Esra Mutlu; Amélie Leclercq; Christine Bleasdale; William Clegg; Richard A Henderson; Bernard T Golding
Trapping of benzene oxide-oxepin and methyl-substituted derivatives with 4-phenyl- and 4-pentafluorophenyl-1,2,4-triazoline-3,5-dione.
Chemical communications (Cambridge, England) 2002;(17):1956-7.
2002: Gilles Laval; William Clegg; Christopher G Crane; Anders Hammershøi; Alan M Sargeson; Bernard T Golding
Assembly of polyamines via amino acids from three components using cobalt(III) template methodology.
Chemical communications (Cambridge, England) 2002;(17):1874-5.
2002: Ashleigh E Gibson; Christine E Arris; Johanne Bentley; F Thomas Boyle; Nicola J Curtin; Thomas G Davies; Jane A Endicott; Bernard T Golding; Sharon Grant; Roger J Griffin; Philip Jewsbury; Louise N Johnson; Veronique Mesguiche; David R Newell; Martin E M Noble; Julie A Tucker; Hayley J Whitfield
Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.
Journal of medicinal chemistry 2002;45(16):3381-93.
2002: Johanna Haglund; Alistair P Henderson; Bernard T Golding; Margareta Törnqvist
Evidence for phosphate adducts in DNA from mice treated with 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Chemical research in toxicology 2002;15(6):773-9.
2002: Marja S Huhta; Daniele Ciceri; Bernard T Golding; E Neil Marsh
A novel reaction between adenosylcobalamin and 2-methyleneglutarate catalyzed by glutamate mutase.
Biochemistry 2002;41(9):3200-6.
2002: Ian R Hardcastle; Bernard T Golding; Roger J Griffin
Designing inhibitors of cyclin-dependent kinases.
Annual review of pharmacology and toxicology 2002;42():325-48.
2001: Martin Stockley; W Clegg; G Fontana; Bernard T Golding; Niall Martin; Laurent Rigoreau; Graeme C M Smith; Roger J Griffin
Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).
Bioorganic & medicinal chemistry letters 2001;11(21):2837-41.
2001: Lisa Cottrell; Bernard T Golding; Tony Munter; William P Watson
In vitro metabolism of chloroprene: species differences, epoxide stereochemistry and a de-chlorination pathway.
Chemical research in toxicology 2001;14(11):1552-62.
2001: Peter G Smith; Huw D Thomas; Hannah C Barlow; Roger J Griffin; Bernard T Golding; A Hilary Calvert; David R Newell; Nicola J Curtin
In vitro and in vivo properties of novel nucleoside transport inhibitors with improved pharmacological properties that potentiate antifolate activity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2105-13.
2001: William P Watson; Lisa Cottrell; D Zhang; Bernard T Golding
Metabolism and molecular toxicology of isoprene.
Chemico-biological interactions 2001;135-136():223-38.
2000: Alex W White; Robert Almassy; A Hilary Calvert; Nicola J Curtin; Roger J Griffin; Zdenek Hostomsky; Karen A Maegley; David R Newell; S Srinivasan; Bernard T Golding
Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.
Journal of medicinal chemistry 2000;43(22):4084-97.
2000: Roger J Griffin; Christine E Arris; Christine Bleasdale; F Thomas Boyle; A Hilary Calvert; Nicola J Curtin; C Dalby; S Kanugula; N K Lembicz; David R Newell; A E Pegg; Bernard T Golding
Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
Journal of medicinal chemistry 2000;43(22):4071-83.
2000: Christine E Arris; F Thomas Boyle; A Hilary Calvert; Nicola J Curtin; Jane A Endicott; E F Garman; Ashleigh E Gibson; Bernard T Golding; S Grant; Roger J Griffin; Philip Jewsbury; Louise N Johnson; AM Lawrie; David R Newell; Martin E M Noble; Edward A Sausville; R Schultz; W Yu
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
Journal of medicinal chemistry 2000;43(15):2797-804.
2000: Johanna Haglund; A Rafiq; Lars Ehrenberg; Bernard T Golding; Margareta Törnqvist
Transalkylation of phosphotriesters using Cob(I)alamin: toward specific determination of DNA-phosphate adducts.
Chemical research in toxicology 2000;13(4):253-6.
2000: Hannah C Barlow; Karen J Bowman; Nicola J Curtin; A Hilary Calvert; Bernard T Golding; Bing Huang; Peter J Loughlin; David R Newell; Peter G Smith; Roger J Griffin
Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of alpha1-acid glycoprotein (AGP).
Bioorganic & medicinal chemistry letters 2000;10(6):585-9.
1999: Nicola J Curtin; Karen J Bowman; R N Turner; Bing Huang; Peter J Loughlin; A Hilary Calvert; Bernard T Golding; Roger J Griffin; David R Newell
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.
British journal of cancer 1999;80(11):1738-46.
1998: Roger J Griffin; S Srinivasan; K Bowman; A Hilary Calvert; Nicola J Curtin; David R Newell; L C Pemberton; Bernard T Golding
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Journal of medicinal chemistry 1998;41(26):5247-56.
1998: Karen J Bowman; A White; Bernard T Golding; Roger J Griffin; Nicola J Curtin
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.
British journal of cancer 1998;78(10):1269-77.
1998: Michael J Tilby; H McCartney; K A Gould; C C O'Hare; J A Hartley; A G Hall; Bernard T Golding; P D Lawley
A monofunctional derivative of melphalan: preparation, DNA alkylation products, and determination of the specificity of monoclonal antibodies that recognize melphalan-DNA adducts.
Chemical research in toxicology 1998;11(10):1162-8.
1998: Eden Tareke; Bernard T Golding; R D Small; Margareta Törnqvist
Haemoglobin adducts from isoprene and isoprene monoepoxides.
Xenobiotica; the fate of foreign compounds in biological systems 1998;28(7):663-72.
1998: Andrew B Lindstrom; Karen Yeowell-O'Connell; Suramya Waidyanatha; T A McDonald; Bernard T Golding; Stephen M Rappaport
Formation of hemoglobin and albumin adducts of benzene oxide in mouse, rat, and human blood.
Chemical research in toxicology 1998;11(4):302-10.
1998: H Bothe; Daniel Darley; S P Albracht; Gary J Gerfen; Bernard T Golding; Wolfgang Buckel
Identification of the 4-glutamyl radical as an intermediate in the carbon skeleton rearrangement catalyzed by coenzyme B12-dependent glutamate mutase from Clostridium cochlearium.
Biochemistry 1998;37(12):4105-13.
1997: Christine Bleasdale; R Cameron; C Edwards; Bernard T Golding
Dimethyldioxirane converts benzene oxide/oxepin into (Z,Z)-muconaldehyde and sym-oxepin oxide: modeling the metabolism of benzene and its photooxidative degradation.
Chemical research in toxicology 1997;10(12):1314-8.
1997: R D Small; Bernard T Golding; W P Watson
Species differences in the stereochemistry of the metabolism of isoprene in vitro.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(11):1155-64.
1997: Andrew B Lindstrom; Karen Yeowell-O'Connell; Suramya Waidyanatha; Bernard T Golding; Rogelio Tornero-Velez; Stephen M Rappaport
Measurement of benzene oxide in the blood of rats following administration of benzene.
Carcinogenesis 1997;18(8):1637-41.
1996: C Bleasdale; G Kennedy; J O MacGregor; J Nieschalk; K Pearce; William P Watson; Bernard T Golding
Chemistry of muconaldehydes of possible relevance to the toxicology of benzene.
Environmental health perspectives 1996;104 Suppl 6():1201-9.
1996: C Bleasdale; R D Small; William P Watson; J Wilson; Bernard T Golding
Studies on the molecular toxicology of buta-1,3-diene and isoprene epoxides.
Toxicology 1996;113(1-3):290-3.
1996: G Kennedy; P K Slaich; Bernard T Golding; William P Watson
Structure and mechanism of formation of a new adduct from formaldehyde and guanosine.
Chemico-biological interactions 1996;102(2):93-100.
1996: Bernard T Golding; P K Slaich; G Kennedy; C Bleasdale; William P Watson
Mechanisms of formation of adducts from reactions of glycidaldehyde with 2'-deoxyguanosine and/or guanosine.
Chemical research in toxicology 1996;9(1):147-57.
1995: S Boulton; L C Pemberton; J K Porteous; Nicola J Curtin; Roger J Griffin; Bernard T Golding; Barbara W Durkacz
Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors.
British journal of cancer 1995;72(4):849-56.
1995: Roger J Griffin; Nicola J Curtin; David R Newell; Bernard T Golding; Barbara W Durkacz; A Hilary Calvert
The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.
Biochimie 1995;77(6):408-22.
1994: C E Arris; C Bleasdale; A Hilary Calvert; Nicola J Curtin; C Dalby; Bernard T Golding; Roger J Griffin; J M Lunn; G N Major; David R Newell
Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).
Anti-cancer drug design 1994;9(5):401-8.
1993: C Bleasdale; Bernard T Golding; G Kennedy; J O MacGregor; William P Watson
Reactions of muconaldehyde isomers with nucleophiles including tri-O-acetylguanosine: formation of 1,2-disubstituted pyrroles from reactions of the (Z,Z)-isomer with primary amines.
Chemical research in toxicology 1993;6(4):407-12.
1992: David R Newell; R J Maxwell; Bernard T Golding
In vivo and ex vivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review.
NMR in biomedicine 1992;5(5):273-8.
1990: Bernard T Golding; G Kennedy; William P Watson
Structure determination of adducts from the reaction of (R)-glycidaldehyde and guanosine.
Carcinogenesis 1990;11(5):865-8.
1986: Bernard T Golding; P K Slaich; William P Watson
Reaction of guanosine with glycidaldehyde.
IARC scientific publications 1986;(70):227-31.