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David Goldman

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TOP 3
Rongbao Zhao; I David Goldman
Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.
Rongbao Zhao; Daniel Sanghoon Shin; András Fiser; I David Goldman
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
Michele Visentin; Rongbao Zhao; I David Goldman
The antifolates.

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All Publications

2013: Rongbao Zhao; I David Goldman
Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.
Molecular aspects of medicine 2013;34(2-3):373-85.
2012: Rongbao Zhao; Daniel Sanghoon Shin; András Fiser; I David Goldman
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
American journal of physiology. Cell physiology 2012;303(6):C673-81.
2012: Michele Visentin; Rongbao Zhao; I David Goldman
The antifolates.
Hematology/oncology clinics of North America 2012;26(3):629-48, ix.
2012: Daniel Sanghoon Shin; Enghui H Yap; Rongbao Zhao; András Fiser; I David Goldman
A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.
American journal of physiology. Cell physiology 2012;302(9):C1405-12.
2012: Michele Visentin; Rongbao Zhao; Min-Hwang Chang; Michael F Romero; I David Goldman
Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1).
Molecular pharmacology 2012;81(2):134-42.
2011: Kris Michael Mahadeo; Madelena Martin; Sonia I Ramirez; Enid Rivera; Pedro J Santiago-Borrero; Carmen L Cadilla; Lisa DiAntonio; Ndeye Diop-Bove; Salvatore Duva; Norma B Lerner; I David Goldman
Prevalence of a loss-of-function mutation in the proton-coupled folate transporter gene (PCFT-SLC46A1) causing hereditary folate malabsorption in Puerto Rico.
The Journal of pediatrics 2011;159(4):623-7.e1.
2011: Rongbao Zhao; Michele Visentin; Ndeye Diop-Bove; I David Goldman
Mechanisms of membrane transport of folates into cells and across epithelia.
Annual review of nutrition 2011;31():177-201.
2011: Rongbao Zhao; Ndeye Diop-Bove; Channa Gila Ovits; Daniel Sanghoon Shin; I David Goldman
Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function.
The Journal of biological chemistry 2011;286(27):24150-8.
2011: Daniel Sanghoon Shin; Kris Michael Mahadeo; Sang Hee Min; Ndeye Diop-Bove; Peter Clayton; Rongbao Zhao; I David Goldman
Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption.
Molecular genetics and metabolism 2011;103(1):33-7.
2011: Rongbao Zhao; Daniel Sanghoon Shin; I David Goldman
Vulnerability of the cysteine-less proton-coupled folate transporter (PCFT-SLC46A1) to mutational stress associated with the substituted cysteine accessibility method.
Biochimica et biophysica acta 2011;1808(4):1140-5.
2010: Daniel Sanghoon Shin; Sang Hee Min; Laura Russell; Rongbao Zhao; András Fiser; I David Goldman
Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.
Blood 2010;116(24):5162-9.
2010: I David Goldman; Shrikanta Chattopadhyay; Rongbao Zhao; Richard Moran
The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs.
Current opinion in investigational drugs (London, England : 2000) 2010;11(12):1409-23.
2010: Berna Atabay; Meral Turker; Esra Arun Ozer; Kris Michael Mahadeo; Ndeye Diop-Bove; I David Goldman
Mutation of the proton-coupled folate transporter gene (PCFT-SLC46A1) in Turkish siblings with hereditary folate malabsorption.
Pediatric hematology and oncology 2010;27(8):614-9.
2010: Kris Michael Mahadeo; Ndeye Diop-Bove; Daniel Shin; ERSIN SELCUK UNAL; Juliana Teo; Rongbao Zhao; Min-Hwang Chang; Andreas Fulterer; Michael F Romero; I David Goldman
Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption.
American journal of physiology. Cell physiology 2010;299(5):C1153-61.
2010: B Renee Bozard; Preethi S Ganapathy; Jennifer Duplantier; Barbara Mysona; Yonju Ha; Penny Roon; Robert Smith; I David Goldman; Puttur D Prasad; Pamela Moore Martin; Vadivel Ganapathy; Sylvia B Smith
Molecular and biochemical characterization of folate transport proteins in retinal Müller cells.
Investigative ophthalmology & visual science 2010;51(6):3226-35.
2010: Rongbao Zhao; ERSIN SELCUK UNAL; Daniel Sanghoon Shin; I David Goldman
Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.
Biochemistry 2010;49(13):2925-31.
2009: Ndeye Khady Diop-Bove; Julia Wu; Rongbao Zhao; Joseph Locker; I David Goldman
Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line.
Molecular cancer therapeutics 2009;8(8):2424-31.
2009: ERSIN SELCUK UNAL; Rongbao Zhao; I David Goldman
Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.
American journal of physiology. Cell physiology 2009;297(1):C66-74.
2009: ERSIN SELCUK UNAL; Rongbao Zhao; Min-Hwang Chang; András Fiser; Michael F Romero; I David Goldman
The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.
The Journal of biological chemistry 2009;284(26):17846-57.
2009: Rongbao Zhao; Sang Hee Min; Yanhua Wang; Estela Campanella; Philip S Low; I David Goldman
A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.
The Journal of biological chemistry 2009;284(7):4267-74.
2009: Rongbao Zhao; Larry H Matherly; I David Goldman
Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.
Expert reviews in molecular medicine 2009;11():e4.
2008: Sang Hee Min; Sun Young Oh; George I Karp; Mortimer Poncz; Rongbao Zhao; I David Goldman
The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption.
The Journal of pediatrics 2008;153(3):435-7.
2008: Rongbao Zhao; Andong Qiu; Eugenia Tsai; Michaela Jansen; Myles H Akabas; I David Goldman
The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.
Molecular pharmacology 2008;74(3):854-62.
2008: Ersin Selcuk Unal; Rongbao Zhao; Andong Qiu; I David Goldman
N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT).
Biochimica et biophysica acta 2008;1778(6):1407-14.
2008: Sang Hee Min; I David Goldman; Rongbao Zhao
Caffeine markedly sensitizes human mesothelioma cell lines to pemetrexed.
Cancer chemotherapy and pharmacology 2008;61(5):819-27.
2008: Jan B Wollack; Benedette Makori; Stuti Ahlawat; Rajeth Koneru; Sonia C Picinich; Angela Smith; I David Goldman; Andong Qiu; Peter Cole; John Glod; Barton A. Kamen
Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model.
Journal of neurochemistry 2008;104(6):1494-503.
2007: Andong Qiu; Sang Hee Min; Michaela Jansen; Usha Malhotra; Eugenia Tsai; Diane C Cabelof; Larry H Matherly; Rongbao Zhao; Myles H Akabas; I David Goldman
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.
American journal of physiology. Cell physiology 2007;293(5):C1669-78.
2007: Rongbao Zhao; Sang Hee Min; Andong Qiu; Antoinette Sakaris; Gary L Goldberg; Claudio Sandoval; J Jeffrey Malatack; David S Rosenblatt; I David Goldman
The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption.
Blood 2007;110(4):1147-52.
2007: Shrikanta Chattopadhyay; Roni Tamari; Sang Hee Min; Rongbao Zhao; Eugenia Tsai; I David Goldman
Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability.
The oncologist 2007;12(7):808-15.
2007: Tianhong Li; Yi-He Ling; I David Goldman; Roman Perez-Soler
Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3413-22.
2007: Rongbao Zhao; I David Goldman
The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed.
Cancer metastasis reviews 2007;26(1):129-39.
2007: Shrikanta Chattopadhyay; Richard G Moran; I David Goldman
Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications.
Molecular cancer therapeutics 2007;6(2):404-17.
2006: Andong Qiu; Michaela Jansen; Antoinette Sakaris; Sang Hee Min; Shrikanta Chattopadhyay; Eugenia Tsai; Claudio Sandoval; Rongbao Zhao; Myles H Akabas; I David Goldman
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.
Cell 2006;127(5):917-28.
2006: Shrikanta Chattopadhyay; Rongbao Zhao; Eugenia Tsai; Vern L Schramm; I David Goldman
The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.
Molecular cancer therapeutics 2006;5(10):2549-55.
2006: Shrikanta Chattopadhyay; Rongbao Zhao; Sergey A Krupenko; Natalia I Krupenko; I David Goldman
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Molecular cancer therapeutics 2006;5(2):438-49.
2005: Rongbao Zhao; Marie Hanscom; I David Goldman
The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells.
Biochimica et biophysica acta 2005;1715(1):57-64.
2005: Rongbao Zhao; Shubing Zhang; Marie Hanscom; Shrikanta Chattopadhyay; I David Goldman
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1294-301.
2005: Yanhua Wang; Arun Rajgopal; I David Goldman; Rongbao Zhao
Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function.
American journal of physiology. Cell physiology 2005;288(1):C65-71.
2004: Rongbao Zhao; Shrikanta Chattopadhyay; Marie Hanscom; I David Goldman
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8735-42.
2004: Shrikanta Chattopadhyay; Yanhua Wang; Rongbao Zhao; I David Goldman
Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):7986-93.
2004: Yanhua Wang; Rongbao Zhao; I David Goldman
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):6256-64.
2004: Rongbao Zhao; Marie Hanscom; Shrikanta Chattopadhyay; I David Goldman
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Cancer research 2004;64(9):3313-9.
2004: Rongbao Zhao; Feng Gao; Marie Hanscom; I David Goldman
A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(2):718-27.
2004: Rongbao Zhao; I David Goldman
Enter Alimta: a new generation antifolate.
The oncologist 2004;9(3):242-4.
2003: Rongbao Zhao; I David Goldman
Resistance to antifolates.
Oncogene 2003;22(47):7431-57.
2003: Michal Stark; Lilah Rothem; Gerrit Jansen; George L Scheffer; I David Goldman; Yehuda G Assaraf
Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate.
Molecular pharmacology 2003;64(2):220-7.
2003: Rongbao Zhao; Yanhua Wang; Feng Gao; I David Goldman
Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility.
Biochimica et biophysica acta 2003;1613(1-2):49-56.
2003: Yanhua Wang; Rongbao Zhao; I David Goldman
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
Biochemical pharmacology 2003;65(7):1163-70.
2003: Larry H Matherly; I David Goldman
Membrane transport of folates.
Vitamins and hormones 2003;66():403-56.
2002: I David Goldman; Rongbao Zhao
Molecular, biochemical, and cellular pharmacology of pemetrexed.
Seminars in oncology 2002;29(6 Suppl 18):3-17.
2002: Yanhua Wang; Rongbao Zhao; Shrikanta Chattopadhyay; I David Goldman
A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed.
Cancer research 2002;62(22):6434-7.
2002: Rongbao Zhao; Feng Gao; I David Goldman
Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells.
American journal of physiology. Cell physiology 2002;282(6):C1512-7.
2002: Iraida G Sharina; Rongbao Zhao; Yanhua Wang; Solomon Babani; I David Goldman
Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function.
Biochemical pharmacology 2002;63(9):1717-24.
2002: I David Goldman
Membrane transport of chemotherapeutics and drug resistance: beyond the ABC family of exporters to the role of carrier-mediated processes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):4-6.
2001: Arun Rajgopal; A Edmondnson; I David Goldman; Rongbao Zhao
SLC19A3 encodes a second thiamine transporter ThTr2.
Biochimica et biophysica acta 2001;1537(3):175-8.
2001: Arun Rajgopal; EE Sierra; Rongbao Zhao; I David Goldman
Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities.
American journal of physiology. Cell physiology 2001;281(5):C1579-86.
2001: Yanhua Wang; Rongbao Zhao; R G Russell; I David Goldman
Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis.
Biochimica et biophysica acta 2001;1513(1):49-54.
2001: Iraida G Sharina; Rongbao Zhao; Yanhua Wang; Solomon Babani; I David Goldman
Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier.
Molecular pharmacology 2001;59(5):1022-8.
2001: Rongbao Zhao; F Gao; I David Goldman
Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells.
Biochemical pharmacology 2001;61(7):857-65.
2001: Rongbao Zhao; Robert G Russell; Yanhua Wang; L Liu; F Gao; Burkhard Kneitz; Winfried Edelmann; I David Goldman
Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs.
The Journal of biological chemistry 2001;276(13):10224-8.
2001: Rongbao Zhao; Feng Gao; I David Goldman
Molecular cloning of human thiamin pyrophosphokinase.
Biochimica et biophysica acta 2001;1517(2):320-2.
2001: Rongbao Zhao; F Gao; Yanhua Wang; George A Diaz; Bruce D Gelb; I David Goldman
Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells.
The Journal of biological chemistry 2001;276(2):1114-8.
2000: Rongbao Zhao; Solomon Babani; F Gao; L Liu; I David Goldman
The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3687-95.
2000: Rongbao Zhao; Steven A Titus; F Gao; Richard G Moran; I David Goldman
Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.
The Journal of biological chemistry 2000;275(34):26599-606.
2000: Rongbao Zhao; F Gao; Solomon Babani; I David Goldman
Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(8):3304-11.
2000: Rongbao Zhao; F Gao; L Liu; I David Goldman
The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein.
Biochimica et biophysica acta 2000;1466(1-2):7-10.
2000: K A Sharif; I David Goldman
Rapid determination of membrane transport parameters in adherent cells.
BioTechniques 2000;28(5):926-8, 930, 932.
2000: Stavit Drori; Hannah Sprecher; G Shemer; Gerrit Jansen; I David Goldman; Yehuda G Assaraf
Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells.
European journal of biochemistry / FEBS 2000;267(3):690-702.
2000: Rongbao Zhao; F Gao; P J Wang; I David Goldman
Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis.
Molecular pharmacology 2000;57(2):317-23.
1999: Rongbao Zhao; F Gao; I David Goldman
Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
Biochemical pharmacology 1999;58(10):1615-24.
1999: Yehuda G Assaraf; EE Sierra; Solomon Babani; I David Goldman
Inhibitory effects of prostaglandin A1 on membrane transport of folates mediated by both the reduced folate carrier and ATP-driven exporters.
Biochemical pharmacology 1999;58(8):1321-7.
1999: Rongbao Zhao; Iraida G Sharina; I David Goldman
Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis.
Molecular pharmacology 1999;56(1):68-76.
1999: EE Sierra; I David Goldman
Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates.
Seminars in oncology 1999;26(2 Suppl 6):11-23.
1998: Rongbao Zhao; Yehuda G Assaraf; I David Goldman
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
The Journal of biological chemistry 1998;273(30):19065-71.
1998: K A Sharif; Jeffrey A Moscow; I David Goldman
Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast cancer cell lines.
Biochemical pharmacology 1998;55(10):1683-9.
1998: EE Sierra; I David Goldman
Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function.
Biochemical pharmacology 1998;55(9):1505-12.
1998: Yehuda G Assaraf; Solomon Babani; I David Goldman
Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells.
The Journal of biological chemistry 1998;273(14):8106-11.
1998: Rongbao Zhao; Yehuda G Assaraf; I David Goldman
A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate.
The Journal of biological chemistry 1998;273(14):7873-9.
1997: Rongbao Zhao; Richard Seither; Kevin E Brigle; Iraida G Sharina; P J Wang; I David Goldman
Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells.
The Journal of biological chemistry 1997;272(34):21207-12.
1997: Kevin E Brigle; Michael J Spinella; EE Sierra; I David Goldman
Organization of the murine reduced folate carrier gene and identification of variant splice forms.
Biochimica et biophysica acta 1997;1353(2):191-8.
1997: Yehuda G Assaraf; I David Goldman
Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells.
The Journal of biological chemistry 1997;272(28):17460-6.
1997: EE Sierra; Kevin E Brigle; Michael J Spinella; I David Goldman
pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH.
Biochemical pharmacology 1997;53(2):223-31.
1996: Michael J Spinella; Kevin E Brigle; S J Freemantle; EE Sierra; I David Goldman
Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects.
Biochemical pharmacology 1996;52(5):703-12.
1995: EE Sierra; Kevin E Brigle; Michael J Spinella; I David Goldman
Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells.
Biochemical pharmacology 1995;50(8):1287-94.
1995: Kevin E Brigle; Michael J Spinella; EE Sierra; I David Goldman
Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.
The Journal of biological chemistry 1995;270(39):22974-9.
1995: Michael J Spinella; Kevin E Brigle; EE Sierra; I David Goldman
Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells.
The Journal of biological chemistry 1995;270(14):7842-9.
1994: Kevin E Brigle; Richard Seither; E H Westin; I David Goldman
Increased expression and genomic organization of a folate-binding protein homologous to the human placental isoform in L1210 murine leukemia cell lines with a defective reduced folate carrier.
The Journal of biological chemistry 1994;269(6):4267-72.
1994: Kevin E Brigle; Michael J Spinella; E H Westin; I David Goldman
Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells.
Biochemical pharmacology 1994;47(2):337-45.
1992: Kevin E Brigle; E H Westin; M T Houghton; I David Goldman
Insertion of an intracisternal A particle within the 5'-regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression.
The Journal of biological chemistry 1992;267(31):22351-5.
1992: Richard Seither; T J Rape; I David Goldman
Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
Biochemical pharmacology 1992;43(12):2647-54.
1991: Kevin E Brigle; E H Westin; M T Houghton; I David Goldman
Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement.
The Journal of biological chemistry 1991;266(26):17243-9.
1991: D F Trent; Richard Seither; I David Goldman
Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate.
Biochemical pharmacology 1991;42(5):1015-9.
1991: D F Trent; Richard Seither; I David Goldman
Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.
The Journal of biological chemistry 1991;266(9):5445-9.
1991: Richard Seither; D F Trent; D C Mikulecky; T J Rape; I David Goldman
Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition.
The Journal of biological chemistry 1991;266(7):4112-8.
1990: R Pincus; I David Goldman
Evidence for impaired mitoxantrone and vinblastine binding in P388 murine leukemia cells with multidrug resistance.
Biochemical pharmacology 1990;40(12):2625-35.
1990: W B Strong; S J Tendler; Richard Seither; I David Goldman; Verne Schirch
Purification and properties of serine hydroxymethyltransferase and C1-tetrahydrofolate synthase from L1210 cells.
The Journal of biological chemistry 1990;265(21):12149-55.
1989: Larry H Matherly; John D Schuetz; E Westin; I David Goldman
A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase.
Analytical biochemistry 1989;182(2):338-45.
1989: Richard Seither; D F Trent; D C Mikulecky; T J Rape; I David Goldman
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
The Journal of biological chemistry 1989;264(29):17016-23.
1989: John D Schuetz; E H Westin; Larry H Matherly; R Pincus; Paul Steven Swerdlow; I David Goldman
Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier.
The Journal of biological chemistry 1989;264(27):16261-7.
1989: Richard Seither; T J Rape; I David Goldman
Further studies on the pharmacologic effects of the 7-hydroxy catabolite of methotrexate in the L1210 murine leukemia cell.
Biochemical pharmacology 1989;38(5):815-22.
1988: John D Schuetz; Larry H Matherly; E H Westin; I David Goldman
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.
The Journal of biological chemistry 1988;263(20):9840-7.
1988: John D Schuetz; K M Gorse; I David Goldman; E H Westin
Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance.
The Journal of biological chemistry 1988;263(16):7708-12.
1987: G L Wampler; W H Carter; E D Campbell; I David Goldman
Demonstration of a schedule-dependent therapeutic synergism utilizing the interacting drugs methotrexate and teniposide in L1210 leukemia.
Cancer treatment reports 1987;71(6):581-91.
1987: Larry H Matherly; C K Barlowe; V M Phillips; I David Goldman
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
The Journal of biological chemistry 1987;262(2):710-7.
1987: I David Goldman; Larry H Matherly
Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates.
NCI monographs : a publication of the National Cancer Institute 1987;(5):17-26.
1987: Larry H Matherly; Richard Seither; I David Goldman
Metabolism of the diaminoantifolates: biosynthesis and pharmacology of the 7-hydroxyl and polyglutamyl metabolites of methotrexate and related antifolates.
Pharmacology & therapeutics 1987;35(1-2):27-56.
1986: G Fabre; Richard Seither; I David Goldman
Hydroxylation of 4-amino-antifolates by partially purified aldehyde oxidase from rabbit liver.
Biochemical pharmacology 1986;35(8):1325-30.
1986: Larry H Matherly; C K Barlowe; I David Goldman
Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.
Cancer research 1986;46(2):588-93.
1985: M Eleff; P E Franks; G L Wampler; J M Collins; I David Goldman
Analysis of "early" thymidine/inosine protection as an adjunct to methotrexate therapy.
Cancer treatment reports 1985;69(7-8):867-74.
1985: J P Sommadossi; D S Cross; David Gewirtz; I David Goldman; J P Cano; R B Diasio
Evidence from rat hepatocytes of an unrecognized pathway of 5-fluorouracil metabolism with the formation of a glucuronide derivative.
Cancer research 1985;45(6):2450-5.
1985: Gérard Fabre; I Fabre; David Gewirtz; I David Goldman
Characteristics of the formation and membrane transport of 7-hydroxymethotrexate in freshly isolated rabbit hepatocytes.
Cancer research 1985;45(3):1086-91.
1985: Larry H Matherly; M K Voss; L A Anderson; D W Fry; I David Goldman
Enhanced polyglutamylation of aminopterin relative to methotrexate in the Ehrlich ascites tumor cell in vitro.
Cancer research 1985;45(3):1073-8.
1985: J P Sommadossi; David Gewirtz; D S Cross; I David Goldman; J P Cano; R B Diasio
Modulation of 5-fluorouracil catabolism in isolated rat hepatocytes with enhancement of 5-fluorouracil glucuronide formation.
Cancer research 1985;45(1):116-21.
1985: G Fabre; I David Goldman
Formation of 7-hydroxymethotrexate polyglutamyl derivatives and their cytotoxicity in human chronic myelogenous leukemia cells, in vitro.
Cancer research 1985;45(1):80-5.
1985: I David Goldman; Larry H Matherly
The cellular pharmacology of methotrexate.
Pharmacology & therapeutics 1985;28(1):77-102.
1984: I Fabre; Gérard Fabre; I David Goldman
Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro.
Cancer research 1984;44(8):3190-5.
1984: Larry H Matherly; L A Anderson; I David Goldman
Role of the cellular oxidation-reduction state in methotrexate binding to dihydrofolate reductase and dissociation induced by reduced folates.
Cancer research 1984;44(6):2325-30.
1984: Gérard Fabre; I Fabre; Larry H Matherly; J P Cano; I David Goldman
Synthesis and properties of 7-hydroxymethotrexate polyglutamyl derivatives in Ehrlich ascites tumor cells in vitro.
The Journal of biological chemistry 1984;259(8):5066-72.
1984: Jack C Yalowich; I David Goldman
Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro.
Cancer research 1984;44(3):984-9.
1984: Gérard Fabre; Larry H Matherly; I Fabre; J P Cano; I David Goldman
Interactions between 7-hydroxymethotrexate and methotrexate at the cellular level in the Ehrlich ascites tumor in vitro.
Cancer research 1984;44(3):970-5.
1984: David Gewirtz; JK Randolph; I David Goldman
Induction of taurocholate release from isolated rat hepatocytes in suspension by alpha-adrenergic agents and vasopressin: implications for control of bile salt secretion.
Hepatology (Baltimore, Md.) 1984;4(2):205-12.
1983: Larry H Matherly; D W Fry; I David Goldman
Role of methotrexate polyglutamylation and cellular energy metabolism in inhibition of methotrexate binding to dihydrofolate reductase by 5-formyltetrahydrofolate in Ehrlich ascites tumor cells in vitro.
Cancer research 1983;43(6):2694-9.
1983: D W Fry; L A Anderson; M Borst; I David Goldman
Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity.
Cancer research 1983;43(3):1087-92.
1983: D W Fry; David Gewirtz; Jack C Yalowich; I David Goldman
Characteristics of the accumulation of methotrexate polyglutamate derivatives in Ehrlich ascites tumor cells and isolated rat hepatocytes.
Advances in experimental medicine and biology 1983;163():215-34.
1982: David Gewirtz; JK Randolph; I David Goldman
Catecholamine-induced release of the folic acid analogue, methotrexate, from rat hepatocytes in suspension. An alpha-adrenergic phenomenon.
Molecular pharmacology 1982;22(2):493-9.
1982: Jack C Yalowich; D W Fry; I David Goldman
Teniposide (VM-26)- and etoposide (VP-16-213)-induced augmentation of methotrexate transport and polyglutamylation in Ehrlich ascites tumor cells in vitro.
Cancer research 1982;42(9):3648-53.
1982: J P Sommadossi; David Gewirtz; R B Diasio; C Aubert; J P Cano; I David Goldman
Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography.
The Journal of biological chemistry 1982;257(14):8171-6.
1982: D W Fry; Jack C Yalowich; I David Goldman
Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells.
Cancer research 1982;42(7):2532-6.
1982: R L Cybulski; D W Fry; I David Goldman
Approaches to the measurement of intracellular adenine and the discrimination between adenine transport and metabolism in L1210 leukemia cells.
Biochimica et biophysica acta 1982;714(3):435-41.
1982: D W Fry; Jack C Yalowich; I David Goldman
Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro.
The Journal of biological chemistry 1982;257(4):1890-6.
1982: D W Fry; I David Goldman
Further studies on the charge-related alterations of methotrexate transport in Ehrlich ascites tumor cells by ionic liposomes: correlation with liposome-cell association.
The Journal of membrane biology 1982;66(2):87-95.
1981: David Gewirtz; JK Randolph; I David Goldman
Efflux in isolated hepatocytes as a possible correlate of secretion in vivo: induced exit of the folic acid analog methotrexate, by dibutyryl cyclic AMP or isobutyl methyl xanthine.
Biochemical and biophysical research communications 1981;101(2):366-74.
1981: J C White; I David Goldman
Methotrexate resistance in al L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport. Computer simulations based on network thermodynamics.
The Journal of biological chemistry 1981;256(11):5722-7.
1981: R L Cybulski; D W Fry; I David Goldman
Adenosine stimulation of uphill adenine transport in L1210 leukemia cells. Evidence for a novel countertransport mechanism.
The Journal of biological chemistry 1981;256(9):4455-9.
1981: I David Goldman; D Bowen; David Gewirtz
Some considerations in the experimental approach to distinguishing between membrane transport and intracellular disposition of antineoplastic agents, with specific reference to fluorodeoxyuridine, actinomycin D, and methotrexate.
Cancer treatment reports 1981;65 Suppl 3():43-56.
1981: I David Goldman
Membrane transport considerations in high-dose methotrexate regimens with leucovorin rescue.
Cancer treatment reports 1981;65 Suppl 1():13-7.
1980: D W Fry; R L Cybulski; I David Goldman
K+-induced alterations of energetics and exchange diffusion in the carrier-mediated transport of the folic acid analog, methotrexate, in Ehrlich ascites tumor cells.
Biochimica et biophysica acta 1980;603(1):157-70.
1980: D W Fry; J C White; I David Goldman
Effects of 2,4-dinitrophenol and other metabolic inhibitors on the bidirectional carrier fluxes, net transport, and intracellular binding of methotrexate in Ehrlich ascites tumor cells.
Cancer research 1980;40(10):3669-73.
1980: J C White; R A Carchman; D W Fry; I David Goldman
Relationship between membrane transport of methotrexate and endogenous cyclic adenosine 3':5'-monophosphate in the Ehrlich ascites tumor.
Cancer research 1980;40(7):2400-4.
1980: David Gewirtz; JK Randolph; I David Goldman
Potent bile salt and organic anion inhibition of methotrexate uptake and accumulation in the freshly isolated rat hepatocyte.
Cancer research 1980;40(6):1852-7.
1980: David Gewirtz; J C White; JK Randolph; I David Goldman
Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes.
Cancer research 1980;40(3):573-8.
1979: D W Fry; J C White; I David Goldman
Alterations of the carrier-mediated transport of an anionic solute, methotrexate, by charged liposomes in Ehrlich ascites tumor cells.
The Journal of membrane biology 1979;50(2):123-40.
1979: David Gewirtz; J C White; J K Randolph; I David Goldman
Formation of methotrexate polyglutamates in rat hepatocytes.
Cancer research 1979;39(8):2914-8.
1979: B T Hill; B D Bailey; J C White; I David Goldman
Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate.
Cancer research 1979;39(7 Pt 1):2440-6.
1979: D Bowen; R B Diasio; I David Goldman
Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.
The Journal of biological chemistry 1979;254(12):5333-9.
1978: D W Fry; J C White; I David Goldman
Rapid separation of low molecular weight solutes from liposomes without dilution.
Analytical biochemistry 1978;90(2):809-15.
1978: J C White; B D Bailey; I David Goldman
Lack of stereospecificity at carbon 6 of methyltetrahydrofolate transport in Ehrlich ascites tumor cells. Carrier-mediated transport of both stereoisomers.
The Journal of biological chemistry 1978;253(1):242-5.
1978: D Bowen; J C White; I David Goldman
A basis for fluoropyrimidine-induced antagonism to methotrexate in Ehrlich ascites tumor cells in vitro.
Cancer research 1978;38(1):219-22.
1977: I David Goldman
Effects of methotrexate on cellular metabolism: some critical elements in the drug-cell interaction.
Cancer treatment reports 1977;61(4):549-58.
1977: I David Goldman; J M Fyfe; D Bowen; S Loftfield; J A Schafer
The effect of microtubular inhibitors on transport of alpha-aminoisobutyric acid. Inhibition of uphill transport without changes in transmembrane gradients of Na+, K+, or H+.
Biochimica et biophysica acta 1977;467(2):185-91.
1977: I David Goldman
Membrane transport of antifolates as a critical determinant of drug cytotoxicity.
Advances in experimental medicine and biology 1977;84():85-113.
1976: J C White; I David Goldman
Mechanism of action of methotrexate. IV. Free intracellular methotrexate required to suppress dihydrofolate reduction to tetrahydrofolate by Ehrlich ascites tumor cells in vitro.
Molecular pharmacology 1976;12(5):711-9.
1976: I David Goldman; V Gupta; J C White; S Loftfield
Exchangeable intracellular methotrexate levels in the presence and absence of vincristine at extracellular drug concentrations relevant to those achieved in high-dose methotrexate-folinic acid "rescue" protocols.
Cancer research 1976;36(1):276-9.
1975: John Jennette; I David Goldman
Inhibition of the membrane transport of folates by anions retained in uremia.
The Journal of laboratory and clinical medicine 1975;86(5):834-43.
1975: D Bowen; I David Goldman
The relationship among transport, intracellular binding, and inhibition of RNA synthesis by actinomycin D in Ehrlich ascites tumor cells in vitro.
Cancer research 1975;35(11 Pt 1):3054-60.
1975: M J Fyfe; S Loftfield; I David Goldman
A reduction in energy-dependent amino acid transport by microtubular inhibitors in Ehrlich ascites tumor cells.
Journal of cellular physiology 1975;86(2 Pt 1):201-11.
1975: J C White; S Loftfield; I David Goldman
The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of (14C)formate incorporation into nucleic acids and protein.
Molecular pharmacology 1975;11(3):287-97.
1974: I David Goldman; M J Fyfe
The mechanism of action of methotrexate. II. Augmentation by vincristine of inhibition of deoxyribonucleic aic synthesis by methotrexate in Ehrlich ascites tumor cells.
Molecular pharmacology 1974;10(2):275-82.
1974: I David Goldman
The mechanism of action of methotrexate. I. Interaction with a low-affinity intracellular site required for maximum inhibition of deoxyribonucleic acid synthesis in L-cell mouse fibroblasts.
Molecular pharmacology 1974;10(2):257-74.
1973: M J Fyfe; I David Goldman
Characteristics of the vincristine-induced augmentation of methotrexate uptake in Ehrlich ascites tumor cells.
The Journal of biological chemistry 1973;248(14):5067-73.
1972: W F Bobzien; I David Goldman
The mechanism of folate transport in rabbit reticulocytes.
The Journal of clinical investigation 1972;51(7):1688-96.
1971: I David Goldman
The characteristics of the membrane transport of amethopterin and the naturally occurring folates.
Annals of the New York Academy of Sciences 1971;186():400-22.
1971: I David Goldman
A model system for the study of heteroexchange diffusion: methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells.
Biochimica et biophysica acta 1971;233(3):624-34.
1970: D L Lilien; Jerry L Spivak; I David Goldman
Chromate transport in human leukocytes.
The Journal of clinical investigation 1970;49(8):1551-7.
1970: N S Lichtenstein; I David Goldman
Riboflavin-methotrexate interactions. Photochemical reaction and competition for transport in the L1210 mouse leukemia cell.
Biochemical pharmacology 1970;19(4):1229-39.
1969: I David Goldman
Transport energetics of the folic acid analogue, methotrexate, in L1210 leukemia cells. Enhanced accumulation by metabolic inhibitors.
The Journal of biological chemistry 1969;244(14):3779-85.
1969: N S Lichtenstein; V T Oliverio; I David Goldman
Characteristics of folic acid transport in the L1210 leukemia cell.
Biochimica et biophysica acta 1969;193(2):456-67.
1968: I David Goldman; N S Lichtenstein; V T Oliverio
Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.
The Journal of biological chemistry 1968;243(19):5007-17.