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Elizabeth Goldsmith

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

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X Ray Crystallography

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Masato Kato; Lin Li; Jamie Longgood; She Chen; Xinlin Du; David Eisenberg; Doug E Frantz; Elizabeth J Goldsmith; Nick V Grishin; Tina W Han; Hamid Mirzaei; Jimin Pei; Michael R Sawaya; Jay W Schneider; Kevin Shi; Robert Tycko; Leeju C Wu; Shanhai Xie; Steven L McKnight
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.
Elizabeth J Goldsmith
Three-dimensional docking in the MAPK p38α.
Radha Akella; Xiaoshan Min; Qiong Wu; Kevin H Gardner; Elizabeth J Goldsmith
The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution.

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All Publications

2012: Masato Kato; Lin Li; Jamie Longgood; She Chen; Xinlin Du; David Eisenberg; Doug E Frantz; Elizabeth J Goldsmith; Nick V Grishin; Tina W Han; Hamid Mirzaei; Jimin Pei; Michael R Sawaya; Jay W Schneider; Kevin Shi; Robert Tycko; Leeju C Wu; Shanhai Xie; Steven L McKnight
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.
Cell 2012;149(4):753-67.
2011: Elizabeth J Goldsmith
Three-dimensional docking in the MAPK p38α.
Science signaling 2011;4(204):pe47.
2010: Radha Akella; Xiaoshan Min; Qiong Wu; Kevin H Gardner; Elizabeth J Goldsmith
The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution.
Structure (London, England : 1993) 2010;18(12):1571-8.
2010: Elizabeth J Goldsmith; Xiaoshan Min; Haixia He; Tianjun Zhou
Structural studies of MAP Kinase cascade components.
Methods in molecular biology (Clifton, N.J.) 2010;661():223-37.
2009: Seung-Jae Lee; Melanie H Cobb; Elizabeth J Goldsmith
Crystal structure of domain-swapped STE20 OSR1 kinase domain.
Protein science : a publication of the Protein Society 2009;18(2):304-13.
2009: Xiaoshan Min; Radha Akella; Haixia He; John M Humphreys; Susan Tsutakawa; Seung-Jae Lee; John A Tainer; Melanie H Cobb; Elizabeth J Goldsmith
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.
Structure (London, England : 1993) 2009;17(1):96-104.
2009: Elizabeth J Goldsmith; Saurabh Mendiratta; Radha Akella; Kathleen Dahlgren
Natural language query in the biochemistry and molecular biology domains based on cognition search™.
Summit on translational bioinformatics 2009;2009():32-7.
2008: Yi-Heng Hao; Yong Wang; Dara L Burdette; Sohini Mukherjee; Gladys Keitany; Elizabeth J Goldsmith; Kim Orth
Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways.
PloS one 2008;3(1):e1375.
2008: Radha Akella; Thomas M Moon; Elizabeth J Goldsmith
Unique MAP Kinase binding sites.
Biochimica et biophysica acta 2008;1784(1):48-55.
2007: Elizabeth J Goldsmith; Radha Akella; Xiaoshan Min; Tianjun Zhou; John M Humphreys
Substrate and docking interactions in serine/threonine protein kinases.
Chemical reviews 2007;107(11):5065-81.
2007: Mustafa Yazicioglu; Daryl L Goad; Aarati Ranganathan; Angelique Whitehurst; Elizabeth J Goldsmith; Melanie H Cobb
Mutations in ERK2 binding sites affect nuclear entry.
The Journal of biological chemistry 2007;282(39):28759-67.
2007: Jeongmi Lee; Anthony J Michael; Dariusz Martynowski; Elizabeth J Goldsmith; Margaret A Phillips
Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.
The Journal of biological chemistry 2007;282(37):27115-25.
2007: Rahul Shah; Radha Akella; Elizabeth J Goldsmith; Margaret A Phillips
X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity.
Biochemistry 2007;46(10):2831-41.
2006: Julie L Wilsbacher; Yu-Chi Juang; Andrei V Khokhlatchev; Ewen Gallagher; Derk D Binns; Elizabeth J Goldsmith; Melanie H Cobb
Characterization of mitogen-activated protein kinase (MAPK) dimers.
Biochemistry 2006;45(44):13175-82.
2006: Seung-Jae Lee; Tianjun Zhou; Elizabeth J Goldsmith
Crystallization of MAP kinases.
Methods (San Diego, Calif.) 2006;40(3):224-33.
2006: Tianjun Zhou; Liguang Sun; John Humphreys; Elizabeth J Goldsmith
Docking interactions induce exposure of activation loop in the MAP kinase ERK2.
Structure (London, England : 1993) 2006;14(6):1011-9.
2006: Tian-Jun Zhou; Li-Guang Sun; Yan Gao; Elizabeth J Goldsmith
Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.
Acta biochimica et biophysica Sinica 2006;38(6):385-92.
2006: Sohini Mukherjee; Gladys Keitany; Yan Li; Yong Wang; Haydn L Ball; Elizabeth J Goldsmith; Kim Orth
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.
Science (New York, N.Y.) 2006;312(5777):1211-4.
2006: Huamin Zhou; Min Zheng; Jianming Chen; Changchuan Xie; Anand R Kolatkar; Tyler Zarubin; Zhiyun Ye; Radha Akella; Shengcai Lin; Elizabeth J Goldsmith; Jiahuai Han
Determinants that control the specific interactions between TAB1 and p38alpha.
Molecular and cellular biology 2006;26(10):3824-34.
2005: Lisa Lenertz; Byung-Hoon Lee; Xiaoshan Min; Bing-e Xu; Kyle Wedin; Svetlana Earnest; Elizabeth J Goldsmith; Melanie H Cobb
Properties of WNK1 and implications for other family members.
The Journal of biological chemistry 2005;280(29):26653-8.
2005: Bing-e Xu; Byung Hoon Lee; Xiaoshan Min; Lisa Lenertz; Charles J Heise; Steve Stippec; Elizabeth J Goldsmith; Melanie H Cobb
WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.
Cell research 2005;15(1):6-10.
2004: Laurie K Jackson; Jeffrey Baldwin; Radha Akella; Elizabeth J Goldsmith; Margaret A Phillips
Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase.
Biochemistry 2004;43(41):12990-9.
2004: Tianjun Zhou; Malavika Raman; Yan Gao; Svetlana Earnest; Zhu Chen; Mischa Machius; Melanie H Cobb; Elizabeth J Goldsmith
Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K.
Structure (London, England : 1993) 2004;12(10):1891-900.
2004: Byung-Hoon Lee; Xiaoshan Min; Charles J Heise; Bing-e Xu; She Chen; Hongjun Shu; Kate Luby-Phelps; Elizabeth J Goldsmith; Melanie H Cobb
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
Molecular cell 2004;15(5):741-51.
2004: Xiaoshan Min; Byung-Hoon Lee; Melanie H Cobb; Elizabeth J Goldsmith
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Structure (London, England : 1993) 2004;12(7):1303-11.
2004: Thomas Lee; Andrew N Hoofnagle; Yukihito Kabuyama; James Stroud; Xiaoshan Min; Elizabeth J Goldsmith; Lin Chen; Katheryn A Resing; Natalie G Ahn
Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry.
Molecular cell 2004;14(1):43-55.
2004: Elizabeth J Goldsmith; Melanie H Cobb; Chung-I Chang
Structure of MAPKs.
Methods in molecular biology (Clifton, N.J.) 2004;250():127-44.
2003: Laurie K Jackson; Elizabeth J Goldsmith; Margaret A Phillips
X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility.
The Journal of biological chemistry 2003;278(24):22037-43.
2003: Robert C Bergstrom; Gary S Coombs; Sheng Ye; Edwin L Madison; Elizabeth J Goldsmith; David R Corey
Binding of nonphysiological protein and peptide substrates to proteases: differences between urokinase-type plasminogen activator and trypsin and contributions to the evolution of regulated proteolysis.
Biochemistry 2003;42(18):5395-402.
2002: Bing-e Xu; Xiaoshan Min; Steve Stippec; Byung-Hoon Lee; Elizabeth J Goldsmith; Melanie H Cobb
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.
The Journal of biological chemistry 2002;277(50):48456-62.
2002: Elizabeth J Goldsmith; Chung-I Chang
Another twist in helix C and a missing pocket.
Structure (London, England : 1993) 2002;10(7):888-9.
2002: Chung I Chang; Bing-e Xu; Radha Akella; Melanie H Cobb; Elizabeth J Goldsmith
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Molecular cell 2002;9(6):1241-9.
2001: S Ye; Elizabeth J Goldsmith
Serpins and other covalent protease inhibitors.
Current opinion in structural biology 2001;11(6):740-5.
2001: S Ye; A L Cech; R Belmares; Robert C Bergstrom; Y Tong; David R Corey; M R Kanost; Elizabeth J Goldsmith
The structure of a Michaelis serpin-protease complex.
Nature structural biology 2001;8(11):979-83.
2000: Laurie K Jackson; Harold B Brooks; Andrei Osterman; Elizabeth J Goldsmith; Margaret A Phillips
Altering the reaction specificity of eukaryotic ornithine decarboxylase.
Biochemistry 2000;39(37):11247-57.
2000: B Xu; Jessie M English; Julie L Wilsbacher; Steve Stippec; Elizabeth J Goldsmith; Melanie H Cobb
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.
The Journal of biological chemistry 2000;275(22):16795-801.
1999: Nick V Grishin; Andrei Osterman; Harold B Brooks; Margaret A Phillips; Elizabeth J Goldsmith
X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.
Biochemistry 1999;38(46):15174-84.
1999: Julie L Wilsbacher; Elizabeth J Goldsmith; Melanie H Cobb
Phosphorylation of MAP kinases by MAP/ERK involves multiple regions of MAP kinases.
The Journal of biological chemistry 1999;274(24):16988-94.
1999: J Li; Z Wang; BJ Canagarajah; H Jiang; M Kanost; Elizabeth J Goldsmith
The structure of active serpin 1K from Manduca sexta.
Structure (London, England : 1993) 1999;7(1):103-9.
1998: M J Robinson; Steve Stippec; Elizabeth J Goldsmith; Michael A White; Melanie H Cobb
A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.
Current biology : CB 1998;8(21):1141-50.
1998: Z Wang; BJ Canagarajah; J C Boehm; S Kassisà; Melanie H Cobb; Peter Young; Sherin S Abdel-Meguid; J L Adams; Elizabeth J Goldsmith
Structural basis of inhibitor selectivity in MAP kinases.
Structure (London, England : 1993) 1998;6(9):1117-28.
1998: Andrei V Khokhlatchev; BJ Canagarajah; Julie L Wilsbacher; M Robinson; M Atkinson; Elizabeth J Goldsmith; Melanie H Cobb
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.
Cell 1998;93(4):605-15.
1997: BJ Canagarajah; Andrei V Khokhlatchev; Melanie H Cobb; Elizabeth J Goldsmith
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.
Cell 1997;90(5):859-69.
1996: Z Wang; J Mottonen; Elizabeth J Goldsmith
Kinetically controlled folding of the serpin plasminogen activator inhibitor 1.
Biochemistry 1996;35(51):16443-8.
1996: M J Robinson; M Cheng; Andrei V Khokhlatchev; D Ebert; N Ahn; K L Guan; B Stein; Elizabeth J Goldsmith; Melanie H Cobb
Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity.
The Journal of biological chemistry 1996;271(47):29734-9.
1996: M Cheng; E Zhen; M J Robinson; D Ebert; Elizabeth J Goldsmith; Melanie H Cobb
Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3.
The Journal of biological chemistry 1996;271(20):12057-62.
1996: M J Robinson; P C Harkins; J Zhang; R Baer; J W Haycock; Melanie H Cobb; Elizabeth J Goldsmith
Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Biochemistry 1996;35(18):5641-6.
1996: Nick V Grishin; Andrei Osterman; Elizabeth J Goldsmith; Margaret A Phillips
Crystallization and preliminary X-ray studies of ornithine decarboxylase from Trypanosoma brucei.
Proteins 1996;24(2):272-3.
1996: Melanie H Cobb; Shuichan Xu; M Cheng; D Ebert; David J. Robbins; Elizabeth J Goldsmith; M Robinson
Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways.
Advances in pharmacology (San Diego, Calif.) 1996;36():49-65.
1995: Nick V Grishin; Margaret A Phillips; Elizabeth J Goldsmith
Modeling of the spatial structure of eukaryotic ornithine decarboxylases.
Protein science : a publication of the Protein Society 1995;4(7):1291-304.
1995: Melanie H Cobb; Elizabeth J Goldsmith
How MAP kinases are regulated.
The Journal of biological chemistry 1995;270(25):14843-6.
1995: J Zhang; F Zhang; D Ebert; Melanie H Cobb; Elizabeth J Goldsmith
Activity of the MAP kinase ERK2 is controlled by a flexible surface loop.
Structure (London, England : 1993) 1995;3(3):299-307.
1994: Elizabeth J Goldsmith; J Mottonen
Serpins: the uncut version.
Structure (London, England : 1993) 1994;2(4):241-4.
1994: F Zhang; A Strand; David J. Robbins; M H Cobb; Elizabeth J Goldsmith
Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.
Nature 1994;367(6465):704-11.
1993: Edwin L Madison; A Kobe; M J Gething; J F Sambrook; Elizabeth J Goldsmith
Converting tissue plasminogen activator to a zymogen: a regulatory triad of Asp-His-Ser.
Science (New York, N.Y.) 1993;262(5132):419-21.
1992: S S Boddupalli; Charles A Hasemann; K G Ravichandran; Jui-Yun Lu; Elizabeth J Goldsmith; Johann Deisenhofer; Julian A Peterson
Crystallization and preliminary x-ray diffraction analysis of P450terp and the hemoprotein domain of P450BM-3, enzymes belonging to two distinct classes of the cytochrome P450 superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5567-71.
1992: J Mottonen; A Strand; J Symersky; R M Sweet; dennis danley; Kieran F Geoghegan; Robert D Gerard; Elizabeth J Goldsmith
Structural basis of latency in plasminogen activator inhibitor-1.
Nature 1992;355(6357):270-3.
1991: Z Faming; Bostjan Kobe; Caro-Beth Stewart; W J Rutter; Elizabeth J Goldsmith
Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution.
The Journal of biological chemistry 1991;266(36):24606-12.
1991: Stephen R Sprang; S G Withers; Elizabeth J Goldsmith; Robert J Fletterick; N B Madsen
Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate.
Science (New York, N.Y.) 1991;254(5036):1367-71.
1991: Elizabeth J Goldsmith; C Sheng-Cheng; dennis danley; Robert D Gerard; Kieran F Geoghegan; J Mottonen; A Strand
Preliminary X-ray analysis of crystals of plasminogen activator inhibitor-1.
Proteins 1991;9(3):225-7.
1990: Edwin L Madison; Elizabeth J Goldsmith; Mary-Jane Gething; J F Sambrook; Robert D Gerard
Restoration of serine protease-inhibitor interaction by protein engineering.
The Journal of biological chemistry 1990;265(35):21423-6.
1990: Edwin L Madison; Elizabeth J Goldsmith; Robert D Gerard; Mary-Jane Gething; J F Sambrook; Rhonda Bassel-Duby
Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3530-3.
1989: Melanie H Cobb; B C Sang; R Gonzalez; Elizabeth J Goldsmith; L Ellis
Autophosphorylation activates the soluble cytoplasmic domain of the insulin receptor in an intermolecular reaction.
The Journal of biological chemistry 1989;264(31):18701-6.
1989: Elizabeth J Goldsmith; Stephen R Sprang; R Hamlin; Nguyen-Huu Xuong; Robert J Fletterick
Domain separation in the activation of glycogen phosphorylase a.
Science (New York, N.Y.) 1989;245(4917):528-32.
1989: Edwin L Madison; Elizabeth J Goldsmith; Robert D Gerard; Mary-Jane Gething; J F Sambrook
Serpin-resistant mutants of human tissue-type plasminogen activator.
Nature 1989;339(6227):721-4.
1988: S J Gardell; Charles S Craik; E Clauser; Elizabeth J Goldsmith; Caro-Beth Stewart; M Graf; W J Rutter
A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family.
The Journal of biological chemistry 1988;263(33):17828-36.
1988: Stephen R Sprang; K R Acharya; Elizabeth J Goldsmith; David I Stuart; K Varvill; Robert J Fletterick; N B Madsen; Louise N Johnson
Structural changes in glycogen phosphorylase induced by phosphorylation.
Nature 1988;336(6196):215-21.
1987: V L Rath; C B Newgard; Stephen R Sprang; Elizabeth J Goldsmith; Robert J Fletterick
Modeling the biochemical differences between rabbit muscle and human liver phosphorylase.
Proteins 1987;2(3):225-35.
1982: Stephen R Sprang; Elizabeth J Goldsmith; Robert J Fletterick; S G Withers; N B Madsen
Catalytic site of glycogen phosphorylase: structure of the T state and specificity for alpha-D-glucose.
Biochemistry 1982;21(21):5364-71.