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Mark Goldsmith

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Lisa C Osborne; Salim Dhanji; Jonathan W Snow; John J Priatel; Melissa C Ma; M Jill Miners; Hung-Sia Teh; Mark A Goldsmith; Ninan Abraham
Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice.
Athanasia D Panopoulos; Ling Zhang; Jonathan W Snow; Daniel M Jones; Amber M Smith; Karim C El Kasmi; Fulu Liu; Mark A Goldsmith; Daniel C Link; Peter J Murray; Stephanie S Watowich
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.
Ann-Marie Roy; Becky Schweighardt; Lauren A Eckstein; Mark A Goldsmith; Joseph M McCune
Enhanced replication of R5 HIV-1 over X4 HIV-1 in CD4(+)CCR5(+)CXCR4(+) T cells.

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2007: Lisa C Osborne; Salim Dhanji; Jonathan W Snow; John J Priatel; Melissa C Ma; M Jill Miners; Hung-Sia Teh; Mark A Goldsmith; Ninan Abraham
Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice.
The Journal of experimental medicine 2007;204(3):619-31.
2006: Athanasia D Panopoulos; Ling Zhang; Jonathan W Snow; Daniel M Jones; Amber M Smith; Karim C El Kasmi; Fulu Liu; Mark A Goldsmith; Daniel C Link; Peter J Murray; Stephanie S Watowich
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.
Blood 2006;108(12):3682-90.
2005: Ann-Marie Roy; Becky Schweighardt; Lauren A Eckstein; Mark A Goldsmith; Joseph M McCune
Enhanced replication of R5 HIV-1 over X4 HIV-1 in CD4(+)CCR5(+)CXCR4(+) T cells.
Journal of acquired immune deficiency syndromes (1999) 2005;40(3):267-75.
2005: Ninan Abraham; Melissa C Ma; Jonathan W Snow; Melissa Jill Miners; Brian G Herndier; Mark A Goldsmith
Haploinsufficiency identifies STAT5 as a modifier of IL-7-induced lymphomas.
Oncogene 2005;24(33):5252-7.
2005: Prerana Jayakumar; Irina Berger; Frank Autschbach; Mark Weinstein; Benjamin Funke; Eric Verdin; Mark A Goldsmith; Oliver T Keppler
Tissue-resident macrophages are productively infected ex vivo by primary X4 isolates of human immunodeficiency virus type 1.
Journal of virology 2005;79(8):5220-6.
2003: Jonathan W Snow; Ninan Abraham; Melissa C Ma; Sarah K Bronson; Mark A Goldsmith
Transgenic bcl-2 is not sufficient to rescue all hematolymphoid defects in STAT5A/5B-deficient mice.
Experimental hematology 2003;31(12):1253-8.
2003: Jonathan W Snow; Ninan Abraham; Melissa C Ma; Mark A Goldsmith
Bone marrow transplant completely rescues hematolymphoid defects in STAT5A/5B-deficient mice.
Experimental hematology 2003;31(12):1247-52.
2003: Jonathan W Snow; Ninan Abraham; Melissa C Ma; Brian G Herndier; Alexander W Pastuszak; Mark A Goldsmith
Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5042-50.
2003: Michael P Sherman; Carlos M C De Noronha; Lauren A Eckstein; Jason Hataye; Pamela Mundt; Samuel Williams; Jason Neidleman; Mark A Goldsmith; Warner Greene
Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages.
Journal of virology 2003;77(13):7582-9.
2003: andreas jekle; Oliver T Keppler; Erik De Clercq; Dominique Schols; Mark Weinstein; Mark A Goldsmith
In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells.
Journal of virology 2003;77(10):5846-54.
2002: andreas jekle; Birgit Schramm; Prerana Jayakumar; Verena Trautner; Dominique Schols; Erik De Clercq; John Mills; Suzanne M Crowe; Mark A Goldsmith
Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence.
Journal of virology 2002;76(14):6966-73.
2002: Cyril J. Empig; Mark A Goldsmith
Association of the caveola vesicular system with cellular entry by filoviruses.
Journal of virology 2002;76(10):5266-70.
2002: Oliver T Keppler; Frank Welte; Tuan A Ngo; Peggy S Chin; Kathryn S Patton; Chia-Lin Tsou; Nancy W Abbey; Mark E Sharkey; Robert M Grant; Yun You; John D Scarborough; Wilfried Ellmeier; Dan R Littman; Mario Stevenson; Israel F Charo; Brian G Herndier; Roberto F Speck; Mark A Goldsmith
Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.
The Journal of experimental medicine 2002;195(6):719-36.
2002: Jonathan W Snow; Ninan Abraham; Melissa C Ma; Nancy W Abbey; Brian G Herndier; Mark A Goldsmith
STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells.
Blood 2002;99(1):95-101.
2001: DA Eckstein; Michael P Sherman; ML Penn; Peggy S Chin; Carlos M C De Noronha; Warner Greene; Mark A Goldsmith
HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells.
The Journal of experimental medicine 2001;194(10):1407-19.
2001: DA Eckstein; ML Penn; Yael D Korin; Deirdre D Scripture-Adams; Jerome A Zack; Jason F Kreisberg; M Roederer; Michael P Sherman; Peggy S Chin; Mark A Goldsmith
HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues.
Immunity 2001;15(4):671-82.
2001: Jason F Kreisberg; David Kwa; Birgit Schramm; V Trautner; R Connor; Hanneke Schuitemaker; J I Mullins; Angelica B Van't Wout; Mark A Goldsmith
Cytopathicity of human immunodeficiency virus type 1 primary isolates depends on coreceptor usage and not patient disease status.
Journal of virology 2001;75(18):8842-7.
2001: Oliver T Keppler; Wes Yonemoto; Frank Welte; K S Patton; D Iacovides; RE Atchison; T Ngo; D L Hirschberg; Roberto F Speck; Mark A Goldsmith
Susceptibility of rat-derived cells to replication by human immunodeficiency virus type 1.
Journal of virology 2001;75(17):8063-73.
2001: SY Chan; Cyril J. Empig; Frank Welte; Roberto F Speck; Alan L Schmaljohn; Jason F Kreisberg; Mark A Goldsmith
Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses.
Cell 2001;106(1):117-26.
2001: Kunyan Zhang; Mark P Hawken; F Rana; Frank Welte; Suzanne Gartner; Mark A Goldsmith; Christopher Power
Human immunodeficiency virus type 1 clade A and D neurotropism: molecular evolution, recombination, and coreceptor use.
Virology 2001;283(1):19-30.
2001: ML Penn; M Myers; DA Eckstein; Teri Liegler; Matthew Hayden; F Mammano; F Clavel; Steven G Deeks; Robert M Grant; Mark A Goldsmith
Primary and recombinant HIV type 1 strains resistant to protease inhibitors are pathogenic in mature human lymphoid tissues.
AIDS research and human retroviruses 2001;17(6):517-23.
2000: Ursula Esser; Roberto F Speck; K C Deen; RE Atchison; R Sweet; Mark A Goldsmith
Molecular function of the CD4 D1 domain in coreceptor-mediated entry by HIV type 1.
AIDS research and human retroviruses 2000;16(17):1845-54.
2000: Birgit Schramm; ML Penn; Emil H Palacios; Robert M Grant; F Kirchhoff; Mark A Goldsmith
Cytopathicity of human immunodeficiency virus type 2 (HIV-2) in human lymphoid tissue is coreceptor dependent and comparable to that of HIV-1.
Journal of virology 2000;74(20):9594-600.
2000: SY Chan; Melissa C Ma; Mark A Goldsmith
Differential induction of cellular detachment by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
The Journal of general virology 2000;81(Pt 9):2155-9.
2000: Jean-Charles Grivel; ML Penn; DA Eckstein; Birgit Schramm; Roberto F Speck; Nancy W Abbey; Brian G Herndier; Leonid Margolis; Mark A Goldsmith
Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue.
Journal of virology 2000;74(11):5347-51.
2000: SY Chan; Roberto F Speck; Melissa C Ma; Mark A Goldsmith
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
Journal of virology 2000;74(10):4933-7.
2000: Birgit Schramm; ML Penn; Roberto F Speck; SY Chan; Erik De Clercq; Dominique Schols; R I Connor; Mark A Goldsmith
Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease.
Journal of virology 2000;74(1):184-92.
1999: Sarah L Gaffen; SY Lai; Gregory D Longmore; Kathleen D Liu; Mark A Goldsmith
Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.
Blood 1999;94(1):74-86.
1999: Roberto F Speck; Ursula Esser; ML Penn; DA Eckstein; L Pulliam; SY Chan; Mark A Goldsmith
A trans-receptor mechanism for infection of CD4-negative cells by human immunodeficiency virus type 1.
Current biology : CB 1999;9(10):547-50.
1999: Steven A Middleton; FP Barbone; Dana L Johnson; Robin Thurmond; Y You; FJ McMahon; R Jin; O Livnah; Jennifer Tullai; Francis X Farrell; Mark A Goldsmith; Ian A Wilson; Linda Jolliffe
Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide.
The Journal of biological chemistry 1999;274(20):14163-9.
1999: SY Chan; Roberto F Speck; C Power; Sarah L Gaffen; Bruce Chesebro; Mark A Goldsmith
V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.
Journal of virology 1999;73(3):2350-8.
1999: Stephanie S Watowich; Kathleen D Liu; X Xie; SY Lai; A Mikami; Gregory D Longmore; Mark A Goldsmith
Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.
The Journal of biological chemistry 1999;274(9):5415-21.
1999: ML Penn; Jean-Charles Grivel; Birgit Schramm; Mark A Goldsmith; Leonid Margolis
CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):663-8.
1998: O Livnah; Dana L Johnson; Enrico STURA; Francis X Farrell; FP Barbone; Y You; Kathleen D Liu; Mark A Goldsmith; W He; Christopher D Krause; Sidney Pestka; Linda Jolliffe; Ian A Wilson
An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.
Nature structural biology 1998;5(11):993-1004.
1998: Emil H Palacios; L Digilio; H M McClure; Z Chen; Preston A Marx; Mark A Goldsmith; Robert M Grant
Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.
Current biology : CB 1998;8(16):943-6.
1998: Roberto F Speck; ML Penn; J Wimmer; Ursula Esser; Bishop F Hague; Thomas J Kindt; RE Atchison; Mark A Goldsmith
Rabbit cells expressing human CD4 and human CCR5 are highly permissive for human immunodeficiency virus type 1 infection.
Journal of virology 1998;72(7):5728-34.
1998: Mark A Goldsmith; A Mikami; Y You; Kathleen D Liu; L Thomas; PN Pharr; Gregory D Longmore
Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7006-11.
1998: Kathleen D Liu; Sarah L Gaffen; Mark A Goldsmith
JAK/STAT signaling by cytokine receptors.
Current opinion in immunology 1998;10(3):271-8.
1998: Johannes Bauer; Kathleen D Liu; Y You; SY Lai; Mark A Goldsmith
Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis.
The Journal of biological chemistry 1998;273(15):9255-60.
1998: Gregory D Longmore; Y You; J Molden; Kathleen D Liu; A Mikami; SY Lai; PN Pharr; Mark A Goldsmith
Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo.
Blood 1998;91(3):870-8.
1997: Kathleen D Liu; Sarah L Gaffen; Mark A Goldsmith; Warner Greene
Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation.
Current biology : CB 1997;7(11):817-26.
1997: Roberto F Speck; Kathy Wehrly; Emily J Platt; RE Atchison; Israel F Charo; David Kabat; Bruce Chesebro; Mark A Goldsmith
Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop.
Journal of virology 1997;71(9):7136-9.
1997: J Molden; Yuan Chang; Y You; Patrick S Moore; Mark A Goldsmith
A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit.
The Journal of biological chemistry 1997;272(31):19625-31.
1997: J Gosling; FS Monteclaro; RE Atchison; H Arai; Chia-Lin Tsou; Mark A Goldsmith; Israel F Charo
Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5061-6.
1997: SY Lai; J Molden; Mark A Goldsmith
Shared gamma(c) subunit within the human interleukin-7 receptor complex. A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency.
The Journal of clinical investigation 1997;99(2):169-77.
1996: RE Atchison; J Gosling; FS Monteclaro; C Franci; L Digilio; Israel F Charo; Mark A Goldsmith
Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines.
Science (New York, N.Y.) 1996;274(5294):1924-6.
1996: SY Lai; J Molden; Kathleen D Liu; Jennifer M Puck; M D White; Mark A Goldsmith
Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit.
The EMBO journal 1996;15(17):4506-14.
1996: Sarah L Gaffen; SY Lai; M Ha; X Liu; L Hennighausen; Warner Greene; Mark A Goldsmith
Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity.
The Journal of biological chemistry 1996;271(35):21381-90.
1996: Kathleen D Liu; Warner Greene; Mark A Goldsmith
The alpha chain of the IL-2 receptor determines the species specificity of high-affinity IL-2 binding.
Cytokine 1996;8(8):613-21.
1996: SY Lai; W Xu; Sarah L Gaffen; Kathleen D Liu; Gregory D Longmore; Warner Greene; Mark A Goldsmith
The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):231-5.
1995: Kathleen D Liu; SY Lai; Mark A Goldsmith; Warner Greene
Identification of a variable region within the cytoplasmic tail of the IL-2 receptor beta chain that is required for growth signal transduction.
The Journal of biological chemistry 1995;270(38):22176-81.
1995: Mark A Goldsmith; SY Lai; W Xu; M C Amaral; E S Kuczek; L J Parent; Gordon B Mills; K L Tarr; Gregory D Longmore; Warner Greene
Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.
The Journal of biological chemistry 1995;270(37):21729-37.
1995: Sarah L Gaffen; SY Lai; W Xu; F Gouilleux; B Groner; Mark A Goldsmith; Warner Greene
Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7192-6.
1995: Mark A Goldsmith; M T Warmerdam; RE Atchison; M Miller; Warner Greene
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.
Journal of virology 1995;69(7):4112-21.
1995: Mark A Goldsmith; M C Amaral; Warner Greene
Ligand binding by the IL-2 receptor is modulated by intracellular determinants of the IL-2 receptor beta-chain.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2033-40.
1994: Mark A Goldsmith; W Xu; M C Amaral; E S Kuczek; Warner Greene
The cytoplasmic domain of the interleukin-2 receptor beta chain contains both unique and functionally redundant signal transduction elements.
The Journal of biological chemistry 1994;269(20):14698-704.
1990: D M Desai; Mark A Goldsmith; Arthur Weiss
A transfected human muscarinic receptor fails to substitute for the T cell antigen receptor complex in CD2-initiated signal transduction.
International immunology 1990;2(7):615-20.
1989: Mark A Goldsmith; D M Desai; T Schultz; Arthur Weiss
Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants.
The Journal of biological chemistry 1989;264(29):17190-7.
1989: J D Fraser; Mark A Goldsmith; Arthur Weiss
Ligand-induced association between the T-cell antigen receptor and two glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7133-7.
1989: Mark A Goldsmith; Linda K Bockenstedt; Paul Dazin; Arthur Weiss
Use of somatic cell mutants to study the signal transduction function of the T cell antigen receptor.
Advances in experimental medicine and biology 1989;254():25-33.
1988: Mark A Goldsmith; Paul Dazin; Arthur Weiss
At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8613-7.
1988: Linda K Bockenstedt; Mark A Goldsmith; M Dustin; D Olive; Timothy A Springer; Arthur Weiss
The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):1904-11.
1988: Mark A Goldsmith; Arthur Weiss
Early signal transduction by the antigen receptor without commitment to T cell activation.
Science (New York, N.Y.) 1988;240(4855):1029-31.
1988: Mark A Goldsmith; Arthur Weiss
Function of the antigen receptor in T cell activation.
Advances in experimental medicine and biology 1988;234():195-211.
1987: Linda K Bockenstedt; Mark A Goldsmith; Gary A Koretzky; Arthur Weiss
The activation of T lymphocytes.
Rheumatic diseases clinics of North America 1987;13(3):411-30.
1987: Mark A Goldsmith; Arthur Weiss
Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6879-83.