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Joseph Goldstein

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Living Beings

Cricetinae

Anatomy

Genes & Molecular Sequences

Amino Acid Sequence

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Physiology

Mutation

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Co-Publications
Name
432
Brown, Michael
19
Hammer, Robert
19
Horton, Jay
14
Luskey, Kenneth
13
Shimomura, Iichiro
13
Herz, Joachim
12
Seabra, Miguel
12
Rawson, Robert
10
Liang, Guosheng
10
Hua, Xianxin
10
Sakai, J
9
Nohturfft, A
9
Bashmakov, Yuriy
8
DeBose-Boyd, Russell
8
Ye, Jin

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Publications

TOP 3
Guan Hong-Ping; Goldstein Joseph L; Brown Michael S; Liang Guosheng
Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice.
Kwon Hyock Joo; Abi-Mosleh Lina; Wang Michael L; Deisenhofer Johann; Goldstein Joseph L; Brown Michael S; Infante Rodney E
Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.
Goldstein Joseph L; Brown Michael S
The LDL receptor.

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All Publications

2009: Guan Hong-Ping; Goldstein Joseph L; Brown Michael S; Liang Guosheng
Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice.
The Journal of biological chemistry 2009;284(36):24644-52.
2009: Kwon Hyock Joo; Abi-Mosleh Lina; Wang Michael L; Deisenhofer Johann; Goldstein Joseph L; Brown Michael S; Infante Rodney E
Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.
Cell 2009;137(7):1213-24.
2009: Goldstein Joseph L; Brown Michael S
The LDL receptor.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):431-8.
2009: Brown Michael S; Goldstein Joseph L
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL.
Journal of lipid research 2009;50 Suppl():S15-27.
2008: Radhakrishnan Arun; Goldstein Joseph L; McDonald Jeffrey G; Brown Michael S
Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance.
Cell metabolism 2008;8(6):512-21.
2008: Goldstein Joseph L
Exuberant unpredictability: sine qua non for priceless and prizeworthy biomedical research.
Nature medicine 2008;14(10):1029-32.
2008: Infante Rodney E; Wang Michael L; Radhakrishnan Arun; Kwon Hyock Joo; Brown Michael S; Goldstein Joseph L
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15287-92.
2008: Yang Jing; Zhao Tong-Jin; Goldstein Joseph L; Brown Michael S
Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10750-5.
2008: Goldstein Joseph L; Brown Michael S
From fatty streak to fatty liver: 33 years of joint publications in the JCI.
The Journal of clinical investigation 2008;118(4):1220-2.
2008: Yang Jing; Brown Michael S; Liang Guosheng; Grishin Nick V; Goldstein Joseph L
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.
Cell 2008;132(3):387-96.
2008: Brown Michael S; Goldstein Joseph L
Selective versus total insulin resistance: a pathogenic paradox.
Cell metabolism 2008;7(2):95-6.
2008: Infante Rodney E; Abi-Mosleh Lina; Radhakrishnan Arun; Dale Jarrod D; Brown Michael S; Goldstein Joseph L
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.
The Journal of biological chemistry 2008;283(2):1052-63.
2008: Infante Rodney E; Radhakrishnan Arun; Abi-Mosleh Lina; Kinch Lisa N; Wang Michael L; Grishin Nick V; Goldstein Joseph L; Brown Michael S
Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop.
The Journal of biological chemistry 2008;283(2):1064-75.
2007: Goldstein Joseph L
Creation and revelation: two different routes to advancement in the biomedical sciences.
Nature medicine 2007;13(10):1151-4.
2007: Radhakrishnan Arun; Ikeda Yukio; Kwon Hyock Joo; Brown Michael S; Goldstein Joseph L
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6511-8.
2007: Sun Li-Ping; Seemann Joachim; Goldstein Joseph L; Brown Michael S
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6519-26.
2006: Goldstein Joseph L
Venture science: climbing the ladder to telomerase, cognitive therapy and in situ hybridization.
Nature medicine 2006;12(10):1129-32.
2006: Engelking Luke J; Evers Bret M; Richardson James A; Goldstein Joseph L; Brown Michael S; Liang Guosheng
Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.
The Journal of clinical investigation 2006;116(9):2356-65.
2006: Gong Yi; Lee Joon No; Brown Michael S; Goldstein Joseph L; Ye Jin
Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6154-9.
2006: Brown Michael S; Goldstein Joseph L
Biomedicine. Lowering LDL--not only how low, but how long?
Science (New York, N.Y.) 2006;311(5768):1721-3.
2006: Goldstein Joseph L; DeBose-Boyd Russell A; Brown Michael S
Protein sensors for membrane sterols.
Cell 2006;124(1):35-46.
2006: Gong Yi; Lee Joon No; Lee Peter C W; Goldstein Joseph L; Brown Michael S; Ye Jin
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
Cell metabolism 2006;3(1):15-24.
2005: Goldstein Joseph L
60 years of winged victories for biomedical research.
Nature medicine 2005;11(10):1023-5.
2005: Engelking Luke J; Liang Guosheng; Hammer Robert E; Takaishi Kiyosumi; Kuriyama Hiroshi; Evers Bret M; Li Wei-Ping; Horton Jay D; Goldstein Joseph L; Brown Michael S
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
The Journal of clinical investigation 2005;115(9):2489-98.
2005: Sun Li-Ping; Li Lu; Goldstein Joseph L; Brown Michael S
Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.
The Journal of biological chemistry 2005;280(28):26483-90.
2005: Wang Chunfu; Gale Michael; Keller Brian C; Huang Hua; Brown Michael S; Goldstein Joseph L; Ye Jin
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication.
Molecular cell 2005;18(4):425-34.
2005: Feramisco Jamison D; Radhakrishnan Arun; Ikeda Yukio; Reitz Julian; Brown Michael S; Goldstein Joseph L
Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3242-7.
2005: Kuriyama Hiroshi; Liang Guosheng; Engelking Luke J; Horton Jay D; Goldstein Joseph L; Brown Michael S
Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.
Cell metabolism 2005;1(1):41-51.
2004: Adams Christopher M; Reitz Julian; De Brabander Jef K; Feramisco Jamison D; Li Lu; Brown Michael S; Goldstein Joseph L
Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs.
The Journal of biological chemistry 2004;279(50):52772-80.
2004: Bilheimer David W; Grundy Scott M; Brown Michael S; Goldstein Joseph L
Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983.
Atherosclerosis. Supplements 2004;5(3):61-5.
2004: Brown Michael S; Goldstein Joseph L
Lowering plasma cholesterol by raising ldl receptors. 1981.
Atherosclerosis. Supplements 2004;5(3):57-9.
2004: Goldstein Joseph L
How a jolt and a bolt in a dentist's chair revolutionized cataract surgery.
Nature medicine 2004;10(10):1032-3.
2004: Goldstein Joseph L
Towering science: an ounce of creativity is worth a ton of impact.
Nature medicine 2004;10(10):1015-7.
2004: Chen Guoxun; Liang Guosheng; Ou Jiafu; Goldstein Joseph L; Brown Michael S
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(31):11245-50.
2004: Radhakrishnan Arun; Sun Li-Ping; Kwon Hyock Joo; Brown Michael S; Goldstein Joseph L
Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain.
Molecular cell 2004;15(2):259-68.
2004: Engelking Luke J; Kuriyama Hiroshi; Hammer Robert E; Horton Jay D; Brown Michael S; Goldstein Joseph L; Liang Guosheng
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
The Journal of clinical investigation 2004;113(8):1168-75.
2004: Feramisco Jamison D; Goldstein Joseph L; Brown Michael S
Membrane topology of human insig-1, a protein regulator of lipid synthesis.
The Journal of biological chemistry 2004;279(9):8487-96.
2003: Ye Jin; Wang Chunfu; Sumpter Rhea; Brown Michael S; Goldstein Joseph L; Gale Michael
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15865-70.
2003: Sever Navdar; Song Bao-Liang; Yabe Daisuke; Goldstein Joseph L; Brown Michael S; DeBose-Boyd Russell A
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.
The Journal of biological chemistry 2003;278(52):52479-90.
2003: Goldstein Joseph L
Lasker awards 2003. Foreword: It's a grand year for celebrating science.
Nature medicine 2003;9(10):1237-8.
2003: Horton Jay D; Shah Nila A; Warrington Janet A; Anderson Norma N; Park Sahng Wook; Brown Michael S; Goldstein Joseph L
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12027-32.
2003: Adams Christopher M; Goldstein Joseph L; Brown Michael S
Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10647-52.
2003: Dobrosotskaya Irina Y; Goldstein Joseph L; Brown Michael S; Rawson Robert B
Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.
The Journal of biological chemistry 2003;278(37):35837-43.
2003: Kasus-Jacobi Anne; Ou Jiafu; Bashmakov Yuriy K; Shelton John M; Richardson James A; Goldstein Joseph L; Brown Michael S
Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins.
The Journal of biological chemistry 2003;278(34):32380-9.
2003: Yabe Daisuke; Komuro Ryutaro; Liang Guosheng; Goldstein Joseph L; Brown Michael S
Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3155-60.
2003: Sever Navdar; Yang Tong; Brown Michael S; Goldstein Joseph L; DeBose-Boyd Russell A
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.
Molecular cell 2003;11(1):25-33.
2002: Goldstein Joseph L; Brown Michael S
Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002.
The Journal of clinical investigation 2002;110(12):S11-3.
2002: Rudenko Gabby; Henry Lisa; Henderson Keith; Ichtchenko Konstantin; Brown Michael S; Goldstein Joseph L; Deisenhofer Johann
Structure of the LDL receptor extracellular domain at endosomal pH.
Science (New York, N.Y.) 2002;298(5602):2353-8.
2002: Goldstein Joseph L
Lasker Awards 2002. Foreword: synergy and symbiosis à la Matisse-Picasso.
Nature medicine 2002;8(10):1053-4.
2002: Yabe Daisuke; Brown Michael S; Goldstein Joseph L
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12753-8.
2002: Yang Tong; Espenshade Peter J; Wright Michael E; Yabe Daisuke; Gong Yi; Aebersold Ruedi; Goldstein Joseph L; Brown Michael S
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Cell 2002;110(4):489-500.
2002: Brown Andrew J; Sun Liping; Feramisco Jamison D; Brown Michael S; Goldstein Joseph L
Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism.
Molecular cell 2002;10(2):237-45.
2002: Horton Jay D; Goldstein Joseph L; Brown Michael S
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.
The Journal of clinical investigation 2002;109(9):1125-31.
2002: Dobrosotskaya I Y; Seegmiller A C; Brown M S; Goldstein J L; Rawson R B
Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila.
Science (New York, N.Y.) 2002;296(5569):879-83.
2002: Liang Guosheng; Yang Jian; Horton Jay D; Hammer Robert E; Goldstein Joseph L; Brown Michael S
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.
The Journal of biological chemistry 2002;277(11):9520-8.
2002: Seegmiller Adam C; Dobrosotskaya Irina; Goldstein Joseph L; Ho Y K; Brown Michael S; Rawson Robert B
The SREBP pathway in Drosophila: regulation by palmitate, not sterols.
Developmental cell 2002;2(2):229-38.
2002: Goldstein Joseph L; Rawson Robert B; Brown Michael S
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis.
Archives of biochemistry and biophysics 2002;397(2):139-48.
2002: Horton J D; Goldstein J L; Brown M S
SREBPs: transcriptional mediators of lipid homeostasis.
Cold Spring Harbor symposia on quantitative biology 2002;67():491-8.
2001: Yang J; Goldstein J L; Hammer R E; Moon Y A; Brown M S; Horton J D
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13607-12.
2001: Goldstein J L
Laskers for 2001: knockout mice and test-tube babies.
Nature medicine 2001;7(10):1079-80.
2001: Ou J; Tu H; Shan B; Luk A; DeBose-Boyd R A; Bashmakov Y; Goldstein J L; Brown M S
Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6027-32.
2001: Goldstein J L; Brown M S
Molecular medicine. The cholesterol quartet.
Science (New York, N.Y.) 2001;292(5520):1310-2.
2001: Matsuda M; Korn B S; Hammer R E; Moon Y A; Komuro R; Horton J D; Goldstein J L; Brown M S; Shimomura I
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
Genes & development 2001;15(10):1206-16.
2001: Zhang J; Ou J; Bashmakov Y; Horton J D; Brown M S; Goldstein J L
Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3756-61.
2001: DeBose-Boyd R A; Ou J; Goldstein J L; Brown M S
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1477-82.
2001: Hannah V C; Ou J; Luong A; Goldstein J L; Brown M S
Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells.
The Journal of biological chemistry 2001;276(6):4365-72.
2000: Ye J; Rawson R B; Komuro R; Chen X; Davé U P; Prywes R; Brown M S; Goldstein J L
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.
Molecular cell 2000;6(6):1355-64.
2000: Repa J J; Liang G; Ou J; Bashmakov Y; Lobaccaro J M; Shimomura I; Shan B; Brown M S; Goldstein J L; Mangelsdorf D J
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
Genes & development 2000;14(22):2819-30.
2000: Yang T; Goldstein J L; Brown M S
Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.
The Journal of biological chemistry 2000;275(38):29881-6.
2000: Nohturfft A; Yabe D; Goldstein J L; Brown M S; Espenshade P J
Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes.
Cell 2000;102(3):315-23.
2000: Luong A; Hannah V C; Brown M S; Goldstein J L
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
The Journal of biological chemistry 2000;275(34):26458-66.
2000: Shimomura I; Matsuda M; Hammer R E; Bashmakov Y; Brown M S; Goldstein J L
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.
Molecular cell 2000;6(1):77-86.
2000: Ye J; Davé U P; Grishin N V; Goldstein J L; Brown M S
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5123-8.
2000: Brown M S; Ye J; Rawson R B; Goldstein J L
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans.
Cell 2000;100(4):391-8.
1999: DeBose-Boyd R A; Brown M S; Li W P; Nohturfft A; Goldstein J L; Espenshade P J
Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.
Cell 1999;99(7):703-12.
1999: Shimomura I; Bashmakov Y; Ikemoto S; Horton J D; Brown M S; Goldstein J L
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13656-61.
1999: Rawson R B; DeBose-Boyd R; Goldstein J L; Brown M S
Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.
The Journal of biological chemistry 1999;274(40):28549-56.
1999: Goldstein J L; Brown M S
Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar.
Proceedings of the Association of American Physicians 1999;111(5):469-79.
1999: Nohturfft A; DeBose-Boyd R A; Scheek S; Goldstein J L; Brown M S
Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11235-40.
1999: Brown M S; Goldstein J L
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11041-8.
1999: Shimomura I; Hammer R E; Ikemoto S; Brown M S; Goldstein J L
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.
Nature 1999;401(6748):73-6.
1999: Cheng D; Espenshade P J; Slaughter C A; Jaen J C; Brown M S; Goldstein J L
Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins.
The Journal of biological chemistry 1999;274(32):22805-12.
1999: Espenshade P J; Cheng D; Goldstein J L; Brown M S
Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins.
The Journal of biological chemistry 1999;274(32):22795-804.
1999: Zelenski N G; Rawson R B; Brown M S; Goldstein J L
Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins.
The Journal of biological chemistry 1999;274(31):21973-80.
1999: Horton J D; Shimano H; Hamilton R L; Brown M S; Goldstein J L
Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.
The Journal of clinical investigation 1999;103(7):1067-76.
1999: Goldstein J L; Brown M S
Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar.
The Journal of clinical investigation 1999;104 Suppl():S19-37.
1998: Korn B S; Shimomura I; Bashmakov Y; Hammer R E; Horton J D; Goldstein J L; Brown M S
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).
The Journal of clinical investigation 1998;102(12):2050-60.
1998: Sakai J; Rawson R B; Espenshade P J; Cheng D; Seegmiller A C; Goldstein J L; Brown M S
Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells.
Molecular cell 1998;2(4):505-14.
1998: Nohturfft A; Brown M S; Goldstein J L
Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12848-53.
1998: Shimomura I; Hammer R E; Richardson J A; Ikemoto S; Bashmakov Y; Goldstein J L; Brown M S
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.
Genes & development 1998;12(20):3182-94.
1998: Rawson R B; Cheng D; Brown M S; Goldstein J L
Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.
The Journal of biological chemistry 1998;273(43):28261-9.
1998: Pai J T; Guryev O; Brown M S; Goldstein J L
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins.
The Journal of biological chemistry 1998;273(40):26138-48.
1998: Duncan E A; Davé U P; Sakai J; Goldstein J L; Brown M S
Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning.
The Journal of biological chemistry 1998;273(28):17801-9.
1998: Nohturfft A; Brown M S; Goldstein J L
Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.
The Journal of biological chemistry 1998;273(27):17243-50.
1998: Horton J D; Shimomura I; Brown M S; Hammer R E; Goldstein J L; Shimano H
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
The Journal of clinical investigation 1998;101(11):2331-9.
1998: Sakai J; Nohturfft A; Goldstein J L; Brown M S
Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.
The Journal of biological chemistry 1998;273(10):5785-93.
1998: Brown M S; Goldstein J L
Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake.
Nutrition reviews 1998;56(2 Pt 2):S1-3; discussion S54-75.
1997: Rawson R B; Zelenski N G; Nijhawan D; Ye J; Sakai J; Hasan M T; Chang T Y; Brown M S; Goldstein J L
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.
Molecular cell 1997;1(1):47-57.
1997: Shimomura I; Bashmakov Y; Shimano H; Horton J D; Goldstein J L; Brown M S
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12354-9.
1997: Shimano H; Shimomura I; Hammer R E; Herz J; Goldstein J L; Brown M S; Horton J D
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
The Journal of clinical investigation 1997;100(8):2115-24.
1997: Scheek S; Brown M S; Goldstein J L
Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11179-83.
1997: Brown M S; Herz J; Goldstein J L
LDL-receptor structure. Calcium cages, acid baths and recycling receptors.
Nature 1997;388(6643):629-30.
1997: Sakai J; Nohturfft A; Cheng D; Ho Y K; Brown M S; Goldstein J L
Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.
The Journal of biological chemistry 1997;272(32):20213-21.
1997: Goldstein J L; Brown M S
The clinical investigator: bewitched, bothered, and bewildered--but still beloved.
The Journal of clinical investigation 1997;99(12):2803-12.
1997: Brown M S; Goldstein J L
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.
Cell 1997;89(3):331-40.
1997: Duncan E A; Brown M S; Goldstein J L; Sakai J
Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.
The Journal of biological chemistry 1997;272(19):12778-85.
1997: Shimano H; Horton J D; Shimomura I; Hammer R E; Brown M S; Goldstein J L
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
The Journal of clinical investigation 1997;99(5):846-54.
1997: Shimomura I; Shimano H; Horton J D; Goldstein J L; Brown M S
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
The Journal of clinical investigation 1997;99(5):838-45.
1996: Nohturfft A; Hua X; Brown M S; Goldstein J L
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13709-14.
1996: Hua X; Nohturfft A; Goldstein J L; Brown M S
Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein.
Cell 1996;87(3):415-26.
1996: Shimano H; Horton J D; Hammer R E; Shimomura I; Brown M S; Goldstein J L
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
The Journal of clinical investigation 1996;98(7):1575-84.
1996: Sakai J; Duncan E A; Rawson R B; Hua X; Brown M S; Goldstein J L
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.
Cell 1996;85(7):1037-46.
1996: Cao G; Goldstein J L; Brown M S
Complementation of mutation in acyl-CoA:cholesterol acyltransferase (ACAT) fails to restore sterol regulation in ACAT-defective sterol-resistant hamster cells.
The Journal of biological chemistry 1996;271(24):14642-8.
1996: Pai J T; Brown M S; Goldstein J L
Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5437-42.
1996: Brown M S; Goldstein J L
Heart attacks: gone with the century?
Science (New York, N.Y.) 1996;272(5262):629.
1996: James G; Goldstein J L; Brown M S
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4454-8.
1996: Hua X; Sakai J; Brown M S; Goldstein J L
Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.
The Journal of biological chemistry 1996;271(17):10379-84.
1996: Wang X; Zelenski N G; Yang J; Sakai J; Brown M S; Goldstein J L
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.
The EMBO journal 1996;15(5):1012-20.
1996: Brown M S; Goldstein J L
Michael S. Brown, MD and Joseph L. Goldstein, MD. 1985 Nobel laureates in medicine.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1996;44(2):14-23.
1995: Hua X; Sakai J; Ho Y K; Goldstein J L; Brown M S
Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection.
The Journal of biological chemistry 1995;270(49):29422-7.
1995: Frykman P K; Brown M S; Yamamoto T; Goldstein J L; Herz J
Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8453-7.
1995: Wang X; Pai J T; Wiedenfeld E A; Medina J C; Slaughter C A; Goldstein J L; Brown M S
Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains.
The Journal of biological chemistry 1995;270(30):18044-50.
1995: Yang J; Brown M S; Ho Y K; Goldstein J L
Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution.
The Journal of biological chemistry 1995;270(20):12152-61.
1995: Armstrong S A; Hannah V C; Goldstein J L; Brown M S
CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.
The Journal of biological chemistry 1995;270(14):7864-8.
1995: James G L; Goldstein J L; Brown M S
Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.
The Journal of biological chemistry 1995;270(11):6221-6.
1995: Sheng Z; Otani H; Brown M S; Goldstein J L
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(4):935-8.
1995: Hua X; Wu J; Goldstein J L; Brown M S; Hobbs H H
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.
Genomics 1995;25(3):667-73.
1995: Garcia C K; Brown M S; Pathak R K; Goldstein J L
cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1.
The Journal of biological chemistry 1995;270(4):1843-9.
1995: Armstrong S A; Brown M S; Goldstein J L; Seabra M C
Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins.
Methods in enzymology 1995;257():30-41.
1995: James G L; Brown M S; Goldstein J L
Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells.
Methods in enzymology 1995;255():38-46.
1994: James G L; Brown M S; Cobb M H; Goldstein J L
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.
The Journal of biological chemistry 1994;269(44):27705-14.
1994: Smeland T E; Seabra M C; Goldstein J L; Brown M S
Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10712-6.
1994: Yang J; Sato R; Goldstein J L; Brown M S
Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.
Genes & development 1994;8(16):1910-9.
1994: Brown M S; Goldstein J L; Havel R J; Steinberg D
Gene therapy for cholesterol.
Nature genetics 1994;7(3):349-50.
1994: Sato R; Yang J; Wang X; Evans M J; Ho Y K; Goldstein J L; Brown M S
Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).
The Journal of biological chemistry 1994;269(25):17267-73.
1994: James G L; Goldstein J L; Pathak R K; Anderson R G; Brown M S
PxF, a prenylated protein of peroxisomes.
The Journal of biological chemistry 1994;269(19):14182-90.
1994: Ishibashi S; Herz J; Maeda N; Goldstein J L; Brown M S
The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4431-5.
1994: Ishibashi S; Goldstein J L; Brown M S; Herz J; Burns D K
Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.
The Journal of clinical investigation 1994;93(5):1885-93.
1994: Wang X; Sato R; Brown M S; Hua X; Goldstein J L
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.
Cell 1994;77(1):53-62.
1994: Garcia C K; Goldstein J L; Pathak R K; Anderson R G; Brown M S
Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle.
Cell 1994;76(5):865-73.
1994: Cremers F P; Armstrong S A; Seabra M C; Brown M S; Goldstein J L
REP-2, a Rab escort protein encoded by the choroideremia-like gene.
The Journal of biological chemistry 1994;269(3):2111-7.
1993: Hua X; Yokoyama C; Wu J; Briggs M R; Brown M S; Goldstein J L; Wang X
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11603-7.
1993: Brown M S; Goldstein J L
Protein prenylation. Mad bet for Rab.
Nature 1993;366(6450):14-5.
1993: Sato R; Goldstein J L; Brown M S
Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9261-5.
1993: Yokoyama C; Wang X; Briggs M R; Admon A; Wu J; Hua X; Goldstein J L; Brown M S
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.
Cell 1993;75(1):187-97.
1993: Andres D A; Milatovich A; Ozçelik T; Wenzlau J M; Brown M S; Goldstein J L; Francke U
cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.
Genomics 1993;18(1):105-12.
1993: Ishibashi S; Brown M S; Goldstein J L; Gerard R D; Hammer R E; Herz J
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.
The Journal of clinical investigation 1993;92(2):883-93.
1993: Briggs M R; Yokoyama C; Wang X; Brown M S; Goldstein J L
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence.
The Journal of biological chemistry 1993;268(19):14490-6.
1993: Wang X; Briggs M R; Hua X; Yokoyama C; Goldstein J L; Brown M S
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization.
The Journal of biological chemistry 1993;268(19):14497-504.
1993: Andres D A; Seabra M C; Brown M S; Armstrong S A; Smeland T E; Cremers F P; Goldstein J L
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein.
Cell 1993;73(6):1091-9.
1993: Armstrong S A; Seabra M C; Südhof T C; Goldstein J L; Brown M S
cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.
The Journal of biological chemistry 1993;268(16):12221-9.
1993: James G L; Goldstein J L; Brown M S; Rawson T E; Somers T C; McDowell R S; Crowley C W; Lucas B K; Levinson A D; Marsters J C
Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.
Science (New York, N.Y.) 1993;260(5116):1937-42.
1993: Andres D A; Goldstein J L; Ho Y K; Brown M S
Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role.
The Journal of biological chemistry 1993;268(2):1383-90.
1993: Seabra M C; Brown M S; Goldstein J L
Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase.
Science (New York, N.Y.) 1993;259(5093):377-81.
1992: Willnow T E; Goldstein J L; Orth K; Brown M S; Herz J
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
The Journal of biological chemistry 1992;267(36):26172-80.
1992: Kim C M; Goldstein J L; Brown M S
cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.
The Journal of biological chemistry 1992;267(32):23113-21.
1992: Brown M S; Goldstein J L
Koch's postulates for cholesterol.
Cell 1992;71(2):187-8.
1992: Seabra M C; Brown M S; Slaughter C A; Südhof T C; Goldstein J L
Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.
Cell 1992;70(6):1049-57.
1992: Brown M S; Goldstein J L; Paris K J; Burnier J P; Marsters J C
Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8313-6.
1992: Goldstein J L; Brown M S
Lipoprotein receptors and the control of plasma LDL cholesterol levels.
European heart journal 1992;13 Suppl B():34-6.
1992: Seabra M C; Goldstein J L; Südhof T C; Brown M S
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.
The Journal of biological chemistry 1992;267(20):14497-503.
1992: Reiss Y; Seabra M C; Brown M S; Goldstein J L
p21ras farnesyltransferase: purification and properties of the enzyme.
Biochemical Society transactions 1992;20(2):487-8.
1992: Yokode M; Pathak R K; Hammer R E; Brown M S; Goldstein J L; Anderson R G
Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice.
The Journal of cell biology 1992;117(1):39-46.
1992: Reiss Y; Brown M S; Goldstein J L
Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme.
The Journal of biological chemistry 1992;267(9):6403-8.
1992: Brown M S; Goldstein J L
The genetic basis of hypercholesterolemia: clinical and therapeutic implications.
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 1992;49(2):135-7.
1992: Ridgway N D; Dawson P A; Ho Y K; Brown M S; Goldstein J L
Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding.
The Journal of cell biology 1992;116(2):307-19.
1992: Hobbs H H; Brown M S; Goldstein J L
Molecular genetics of the LDL receptor gene in familial hypercholesterolemia.
Human mutation 1992;1(6):445-66.
1991: Chen W J; Andres D A; Goldstein J L; Brown M S
Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11368-72.
1991: Herz J; Goldstein J L; Strickland D K; Ho Y K; Brown M S
39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
The Journal of biological chemistry 1991;266(31):21232-8.
1991: Goldstein J L; Brown M S; Stradley S J; Reiss Y; Gierasch L M
Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.
The Journal of biological chemistry 1991;266(24):15575-8.
1991: Chen W J; Andres D A; Goldstein J L; Russell D W; Brown M S
cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1.
Cell 1991;66(2):327-34.
1991: Metherall J E; Ridgway N D; Dawson P A; Goldstein J L; Brown M S
A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase.
The Journal of biological chemistry 1991;266(19):12734-40.
1991: Reiss Y; Seabra M C; Armstrong S A; Slaughter C A; Goldstein J L; Brown M S
Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions.
The Journal of biological chemistry 1991;266(16):10672-7.
1991: Mehta K D; Brown M S; Bilheimer D W; Goldstein J L
The low density lipoprotein receptor in Xenopus laevis. II. Feedback repression mediated by conserved sterol regulatory element.
The Journal of biological chemistry 1991;266(16):10415-9.
1991: Mehta K D; Chen W J; Goldstein J L; Brown M S
The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor.
The Journal of biological chemistry 1991;266(16):10406-14.
1991: Seabra M C; Reiss Y; Casey P J; Brown M S; Goldstein J L
Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit.
Cell 1991;65(3):429-34.
1991: Dawson P A; Metherall J E; Ridgway N D; Brown M S; Goldstein J L
Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
The Journal of biological chemistry 1991;266(14):9128-34.
1991: Reiss Y; Stradley S J; Gierasch L M; Brown M S; Goldstein J L
Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):732-6.
1990: Weisgraber K H; Mahley R W; Kowal R C; Herz J; Goldstein J L; Brown M S
Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1990;265(36):22453-9.
1990: Herz J; Kowal R C; Ho Y K; Brown M S; Goldstein J L
Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.
The Journal of biological chemistry 1990;265(34):21355-62.
1990: Yokode M; Hammer R E; Ishibashi S; Brown M S; Goldstein J L
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.
Science (New York, N.Y.) 1990;250(4985):1273-5.
1990: Pathak R K; Yokode M; Hammer R E; Hofmann S L; Brown M S; Goldstein J L; Anderson R G
Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice.
The Journal of cell biology 1990;111(2):347-59.
1990: Reiss Y; Goldstein J L; Seabra M C; Casey P J; Brown M S
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.
Cell 1990;62(1):81-8.
1990: Kowal R C; Herz J; Weisgraber K H; Mahley R W; Brown M S; Goldstein J L
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1990;265(18):10771-9.
1990: Herz J; Kowal R C; Goldstein J L; Brown M S
Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.
The EMBO journal 1990;9(6):1769-76.
1990: Hofmann S L; Eaton D L; Brown M S; McConathy W J; Goldstein J L; Hammer R E
Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.
The Journal of clinical investigation 1990;85(5):1542-7.
1990: Levanon D; Hsieh C L; Francke U; Dawson P A; Ridgway N D; Brown M S; Goldstein J L
cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19.
Genomics 1990;7(1):65-74.
1990: Brown M S; Goldstein J L
Lipoprotein receptors: therapeutic implications.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1990;8(1):S33-5; discussion S35-6.
1990: Brown M S; Goldstein J L
Atherosclerosis. Scavenging for receptors.
Nature 1990;343(6258):508-9.
1990: Smith J R; Osborne T F; Goldstein J L; Brown M S
Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.
The Journal of biological chemistry 1990;265(4):2306-10.
1990: Chen W J; Goldstein J L; Brown M S
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.
The Journal of biological chemistry 1990;265(6):3116-23.
1990: Goldstein J L; Brown M S
Regulation of the mevalonate pathway.
Nature 1990;343(6257):425-30.
1990: Hobbs H H; Russell D W; Brown M S; Goldstein J L
The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein.
Annual review of genetics 1990;24():133-70.
1989: Russell D W; Brown M S; Goldstein J L
Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins.
The Journal of biological chemistry 1989;264(36):21682-8.
1989: Hofmann S L; Goldstein J L; Orth K; Moomaw C R; Slaughter C A; Brown M S
Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements.
The Journal of biological chemistry 1989;264(30):18083-90.
1989: Dawson P A; Ridgway N D; Slaughter C A; Brown M S; Goldstein J L
cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper.
The Journal of biological chemistry 1989;264(28):16798-803.
1989: Metherall J E; Goldstein J L; Luskey K L; Brown M S
Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.
The Journal of biological chemistry 1989;264(26):15634-41.
1989: Kowal R C; Herz J; Goldstein J L; Esser V; Brown M S
Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5810-4.
1989: Hobbs H H; Leitersdorf E; Leffert C C; Cryer D R; Brown M S; Goldstein J L
Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors.
The Journal of clinical investigation 1989;84(2):656-64.
1989: Van Driel I R; Brown M S; Goldstein J L
Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay.
The Journal of biological chemistry 1989;264(16):9533-8.
1989: Dawson P A; Van der Westhuyzen D R; Goldstein J L; Brown M S
Purification of oxysterol binding protein from hamster liver cytosol.
The Journal of biological chemistry 1989;264(15):9046-52.
1989: Hofmann S L; Brown M S; Lee E; Pathak R K; Anderson R G; Goldstein J L
Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins.
The Journal of biological chemistry 1989;264(14):8260-70.
1988: Gil G; Osborne T F; Goldstein J L; Brown M S
Purification of a protein doublet that binds to six TGG-containing sequences in the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
The Journal of biological chemistry 1988;263(35):19009-19.
1988: Gil G; Smith J R; Goldstein J L; Slaughter C A; Orth K; Brown M S; Osborne T F
Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8963-7.
1988: Smith J R; Osborne T F; Brown M S; Goldstein J L; Gil G
Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
The Journal of biological chemistry 1988;263(34):18480-7.
1988: Swanson L W; Simmons D M; Hofmann S L; Goldstein J L; Brown M S
Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9821-5.
1988: Esser V; Limbird L E; Brown M S; Goldstein J L; Russell D W
Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.
The Journal of biological chemistry 1988;263(26):13282-90.
1988: Nakanishi M; Goldstein J L; Brown M S
Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.
The Journal of biological chemistry 1988;263(18):8929-37.
1988: Peacock S L; Bates M P; Russell D W; Brown M S; Goldstein J L
Human low density lipoprotein receptor expressed in Xenopus oocytes. Conserved signals for O-linked glycosylation and receptor-mediated endocytosis.
The Journal of biological chemistry 1988;263(16):7838-45.
1988: Pathak R K; Merkle R K; Cummings R D; Goldstein J L; Brown M S; Anderson R G
Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex.
The Journal of cell biology 1988;106(6):1831-41.
1988: Hofmann S L; Russell D W; Brown M S; Goldstein J L; Hammer R E
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.
Science (New York, N.Y.) 1988;239(4845):1277-81.
1988: Hobbs H H; Leitersdorf E; Goldstein J L; Brown M S; Russell D W
Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions.
The Journal of clinical investigation 1988;81(3):909-17.
1988: Osborne T F; Gil G; Goldstein J L; Brown M S
Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element.
The Journal of biological chemistry 1988;263(7):3380-7.
1988: Dawson P A; Hofmann S L; van der Westhuyzen D R; Südhof T C; Brown M S; Goldstein J L
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.
The Journal of biological chemistry 1988;263(7):3372-9.
1987: van Driel I R; Goldstein J L; Südhof T C; Brown M S
First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins.
The Journal of biological chemistry 1987;262(36):17443-9.
1987: van Driel I R; Davis C G; Goldstein J L; Brown M S
Self-association of the low density lipoprotein receptor mediated by the cytoplasmic domain.
The Journal of biological chemistry 1987;262(33):16127-34.
1987: Brown M S; Goldstein J L
Plasma lipoproteins: teaching old dogmas new tricks.
Nature 1987;330(6144):113-4.
1987: Hobbs H H; Brown M S; Russell D W; Davignon J; Goldstein J L
Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia.
The New England journal of medicine 1987;317(12):734-7.
1987: Goldstein J L; Brown M S
Regulation of low-density lipoprotein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis.
Circulation 1987;76(3):504-7.
1987: Hofmann S L; Russell D W; Goldstein J L; Brown M S
mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(17):6312-6.
1987: Südhof T C; Van der Westhuyzen D R; Goldstein J L; Brown M S; Russell D W
Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.
The Journal of biological chemistry 1987;262(22):10773-9.
1987: Kishimoto A; Goldstein J L; Brown M S
Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein.
The Journal of biological chemistry 1987;262(19):9367-73.
1987: Jingami H; Brown M S; Goldstein J L; Anderson R G; Luskey K L
Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum.
The Journal of cell biology 1987;104(6):1693-704.
1987: Osborne T F; Gil G; Brown M S; Kowal R C; Goldstein J L
Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(11):3614-8.
1987: Davis C G; Goldstein J L; Südhof T C; Anderson R G; Russell D W; Brown M S
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region.
Nature 1987;326(6115):760-5.
1987: Gil G; Smith J R; Goldstein J L; Brown M S
Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(7):1863-6.
1987: Lehrman M A; Russell D W; Goldstein J L; Brown M S
Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia.
The Journal of biological chemistry 1987;262(7):3354-61.
1987: Lehrman M A; Goldstein J L; Russell D W; Brown M S
Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia.
Cell 1987;48(5):827-35.
1987: Davis C G; van Driel I R; Russell D W; Brown M S; Goldstein J L
The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.
The Journal of biological chemistry 1987;262(9):4075-82.
1987: Südhof T C; Russell D W; Brown M S; Goldstein J L
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter.
Cell 1987;48(6):1061-9.
1987: Kishimoto A; Brown M S; Slaughter C A; Goldstein J L
Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II.
The Journal of biological chemistry 1987;262(3):1344-51.
1987: Lehrman M A; Schneider W J; Brown M S; Davis C G; Elhammer A; Russell D W; Goldstein J L
The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum.
The Journal of biological chemistry 1987;262(1):401-10.
1986: Ma P T; Gil G; Südhof T C; Bilheimer D W; Goldstein J L; Brown M S
Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8370-4.
1986: Hobbs H H; Brown M S; Goldstein J L; Russell D W
Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia.
The Journal of biological chemistry 1986;261(28):13114-20.
1986: Lehrman M A; Russell D W; Goldstein J L; Brown M S
Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3679-83.
1986: Yamamoto T; Bishop R W; Brown M S; Goldstein J L; Russell D W
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit.
Science (New York, N.Y.) 1986;232(4755):1230-7.
1986: Davis C G; Lehrman M A; Russell D W; Anderson R G; Brown M S; Goldstein J L
The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors.
Cell 1986;45(1):15-24.
1986: Brown M S; Goldstein J L
A receptor-mediated pathway for cholesterol homeostasis.
Science (New York, N.Y.) 1986;232(4746):34-47.
1986: Gil G; Brown M S; Goldstein J L
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. II. Isolation of the gene and characterization of the 5' flanking region.
The Journal of biological chemistry 1986;261(8):3717-24.
1986: Gil G; Goldstein J L; Slaughter C A; Brown M S
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.
The Journal of biological chemistry 1986;261(8):3710-6.
1986: Davis C G; Elhammer A; Russell D W; Schneider W J; Kornfeld S; Brown M S; Goldstein J L
Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.
The Journal of biological chemistry 1986;261(6):2828-38.
1986: Ma P T; Yamamoto T; Goldstein J L; Brown M S
Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(3):792-6.
1986: Russell D W; Lehrman M A; Südhof T C; Yamamoto T; Davis C G; Hobbs H H; Brown M S; Goldstein J L
The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():811-9.
1986: Goldstein J L; Brown M S
Atherosclerosis and its complications: contributions from the Association of American Physicians, 1886-1986.
Transactions of the Association of American Physicians 1986;99():ccxxxi-ccxlvii.
1985: Goldstein J L; Brown M S
Familial hypercholesterolemia: a genetic receptor disease.
Hospital practice (Office ed.) 1985;20(11):35-41, 45-6.
1985: Brown M S; Goldstein J L
Scavenger cell receptor shared.
Nature 1985;316(6030):680-1.
1985: Osborne T F; Goldstein J L; Brown M S
5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription.
Cell 1985;42(1):203-12.
1985: Reynolds G A; Goldstein J L; Brown M S
Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region.
The Journal of biological chemistry 1985;260(18):10369-77.
1985: Lehrman M A; Goldstein J L; Brown M S; Russell D W; Schneider W J
Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain.
Cell 1985;41(3):735-43.
1985: Gil G; Faust J R; Chin D J; Goldstein J L; Brown M S
Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme.
Cell 1985;41(1):249-58.
1985: Südhof T C; Russell D W; Goldstein J L; Brown M S; Sanchez-Pescador R; Bell G I
Cassette of eight exons shared by genes for LDL receptor and EGF precursor.
Science (New York, N.Y.) 1985;228(4701):893-5.
1985: Südhof T C; Goldstein J L; Brown M S; Russell D W
The LDL receptor gene: a mosaic of exons shared with different proteins.
Science (New York, N.Y.) 1985;228(4701):815-22.
1985: Chin D J; Gil G; Faust J R; Goldstein J L; Brown M S; Luskey K L
Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA.
Molecular and cellular biology 1985;5(4):634-41.
1985: Liscum L; Finer-Moore J; Stroud R M; Luskey K L; Brown M S; Goldstein J L
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.
The Journal of biological chemistry 1985;260(1):522-30.
1985: Lehrman M A; Schneider W J; Südhof T C; Brown M S; Goldstein J L; Russell D W
Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains.
Science (New York, N.Y.) 1985;227(4683):140-6.
1985: Brown M S; Goldstein J L
The LDL receptor and HMG-CoA reductase--two membrane molecules that regulate cholesterol homeostasis.
Current topics in cellular regulation 1985;26():3-15.
1985: Schneider W J; Goldstein J L; Brown M S
Purification of the LDL receptor.
Methods in enzymology 1985;109():405-17.
1985: Goldstein J L; Brown M S
The LDL receptor and the regulation of cellular cholesterol metabolism.
Journal of cell science. Supplement 1985;3():131-7.
1985: Brown M S; Goldstein J L
The receptor model for transport of cholesterol in plasma.
Annals of the New York Academy of Sciences 1985;454():178-82.
1985: Goldstein J L; Brown M S; Anderson R G; Russell D W; Schneider W J
Receptor-mediated endocytosis: concepts emerging from the LDL receptor system.
Annual review of cell biology 1985;1():1-39.
1984: Huettinger M; Corbett J R; Schneider W J; Willerson J T; Brown M S; Goldstein J L
Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7599-603.
1984: Goldstein J L; Brown M S
Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol.
Journal of lipid research 1984;25(13):1450-61.
1984: Bilheimer D W; Goldstein J L; Grundy S M; Starzl T E; Brown M S
Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia.
The New England journal of medicine 1984;311(26):1658-64.
1984: Brown M S; Goldstein J L
How LDL receptors influence cholesterol and atherosclerosis.
Scientific American 1984;251(5):58-66.
1984: Yamamoto T; Davis C G; Brown M S; Schneider W J; Casey M L; Goldstein J L; Russell D W
The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA.
Cell 1984;39(1):27-38.
1984: Huettinger M; Schneider W J; Ho Y K; Goldstein J L; Brown M S
Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits.
The Journal of clinical investigation 1984;74(3):1017-26.
1984: Anderson R G; Falck J R; Goldstein J L; Brown M S
Visualization of acidic organelles in intact cells by electron microscopy.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(15):4838-42.
1984: Reynolds G A; Basu S K; Osborne T F; Chin D J; Gil G; Brown M S; Goldstein J L; Luskey K L
HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions.
Cell 1984;38(1):275-85.
1984: Russell D W; Schneider W J; Yamamoto T; Luskey K L; Brown M S; Goldstein J L
Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor.
Cell 1984;37(2):577-85.
1984: Francke U; Brown M S; Goldstein J L
Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(9):2826-30.
1984: Orci L; Brown M S; Goldstein J L; Garcia-Segura L M; Anderson R G
Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells.
Cell 1984;36(4):835-45.
1984: Chin D J; Gil G; Russell D W; Liscum L; Luskey K L; Basu S K; Okayama H; Berg P; Goldstein J L; Brown M S
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum.
Nature 1984;308(5960):613-7.
1983: Liscum L; Cummings R D; Anderson R G; DeMartino G N; Goldstein J L; Brown M S
3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(23):7165-9.
1983: Cummings R D; Kornfeld S; Schneider W J; Hobgood K K; Tolleshaug H; Brown M S; Goldstein J L
Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.
The Journal of biological chemistry 1983;258(24):15261-73.
1983: Russell D W; Yamamoto T; Schneider W J; Slaughter C J; Brown M S; Goldstein J L
cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(24):7501-5.
1983: Mosley S T; Brown M S; Anderson R G; Goldstein J L
Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase.
The Journal of biological chemistry 1983;258(22):13875-81.
1983: Schneider W J; Slaughter C J; Goldstein J L; Anderson R G; Capra J D; Brown M S
Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts.
The Journal of cell biology 1983;97(5 Pt 1):1635-40.
1983: Schneider W J; Brown M S; Goldstein J L
Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia.
Molecular biology & medicine 1983;1(3):353-67.
1983: Anderson R G; Orci L; Brown M S; Garcia-Segura L M; Goldstein J L
Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol.
Journal of cell science 1983;63():1-20.
1983: Brown M S; Goldstein J L
Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
The Journal of clinical investigation 1983;72(3):743-7.
1983: Goldstein J L; Kita T; Brown M S
Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia.
The New England journal of medicine 1983;309(5):288-96.
1983: Luskey K L; Faust J R; Chin D J; Brown M S; Goldstein J L
Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.
The Journal of biological chemistry 1983;258(13):8462-9.
1983: Liscum L; Luskey K L; Chin D J; Ho Y K; Goldstein J L; Brown M S
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.
The Journal of biological chemistry 1983;258(13):8450-5.
1983: Bilheimer D W; Grundy S M; Brown M S; Goldstein J L
Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):4124-8.
1983: Larkin J M; Brown M S; Goldstein J L; Anderson R G
Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts.
Cell 1983;33(1):273-85.
1983: Dietschy J M; Kita T; Suckling K E; Goldstein J L; Brown M S
Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors.
Journal of lipid research 1983;24(4):469-80.
1983: Daniel T O; Schneider W J; Goldstein J L; Brown M S
Visualization of lipoprotein receptors by ligand blotting.
The Journal of biological chemistry 1983;258(7):4606-11.
1983: Tolleshaug H; Hobgood K K; Brown M S; Goldstein J L
The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor.
Cell 1983;32(3):941-51.
1983: Brown M S; Anderson R G; Goldstein J L
Recycling receptors: the round-trip itinerary of migrant membrane proteins.
Cell 1983;32(3):663-7.
1983: Basu S K; Goldstein J L; Brown M S
Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages.
Science (New York, N.Y.) 1983;219(4586):871-3.
1983: Buja L M; Kita T; Goldstein J L; Watanabe Y; Brown M S
Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia.
Arteriosclerosis (Dallas, Tex.) 1983;3(1):87-101.
1983: Bilheimer D W; Grundy S M; Brown M S; Goldstein J L
Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.
Transactions of the Association of American Physicians 1983;96():1-9.
1983: Goldstein J L; Basu S K; Brown M S
Receptor-mediated endocytosis of low-density lipoprotein in cultured cells.
Methods in enzymology 1983;98():241-60.
1983: Brown M S; Goldstein J L
Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.
Annual review of biochemistry 1983;52():223-61.
1982: Chin D J; Luskey K L; Faust J R; MacDonald R J; Brown M S; Goldstein J L
Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(24):7704-8.
1982: Havel R J; Kita T; Kotite L; Kane J P; Hamilton R L; Goldstein J L; Brown M S
Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.
Arteriosclerosis (Dallas, Tex.) 1982;2(6):467-74.
1982: Beisiegel U; Schneider W J; Brown M S; Goldstein J L
Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia.
The Journal of biological chemistry 1982;257(21):13150-6.
1982: Luskey K L; Chin D J; MacDonald R J; Liscum L; Goldstein J L; Brown M S
Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(20):6210-4.
1982: Tolleshaug H; Goldstein J L; Schneider W J; Brown M S
Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia.
Cell 1982;30(3):715-24.
1982: Carpentier J L; Gorden P; Anderson R G; Goldstein J L; Brown M S; Cohen S; Orci L
Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts.
The Journal of cell biology 1982;95(1):73-7.
1982: Kita T; Brown M S; Bilheimer D W; Goldstein J L
Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(18):5693-7.
1982: Faust J R; Luskey K L; Chin D J; Goldstein J L; Brown M S
Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(17):5205-9.
1982: Zannis V I; Breslow J L; Utermann G; Mahley R W; Weisgraber K H; Havel R J; Goldstein J L; Brown M S; Schonfeld G; Hazzard W R; Blum C
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.
Journal of lipid research 1982;23(6):911-4.
1982: Basu S K; Ho Y K; Brown M S; Bilheimer D W; Anderson R G; Goldstein J L
Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes.
The Journal of biological chemistry 1982;257(16):9788-95.
1982: Anderson R G; Brown M S; Beisiegel U; Goldstein J L
Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies.
The Journal of cell biology 1982;93(3):523-31.
1982: Kita T; Goldstein J L; Brown M S; Watanabe Y; Hornick C A; Havel R J
Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(11):3623-7.
1982: Goldstein J L; Brown M S
The LDL receptor defect in familial hypercholesterolemia. Implications for pathogenesis and therapy.
The Medical clinics of North America 1982;66(2):335-62.
1982: Schneider W J; Beisiegel U; Goldstein J L; Brown M S
Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.
The Journal of biological chemistry 1982;257(5):2664-73.
1982: Chin D J; Luskey K L; Anderson R G; Faust J R; Goldstein J L; Brown M S
Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(4):1185-9.
1982: Goldstein J L; Kottke B A; Brown M S
Biochemical genetics of LDL receptor mutations in familial hypercholesterolemia.
Progress in clinical and biological research 1982;103 Pt B():161-76.
1982: Brown M S; Goldstein J L
Receptor-mediated endocytosis and the structural organization of the cell membrane.
National Cancer Institute monograph 1982;60():3-6.
1982: Brown M S; Anderson R G; Basu S K; Goldstein J L
Recycling of cell-surface receptors: observations from the LDL receptor system.
Cold Spring Harbor symposia on quantitative biology 1982;46 Pt 2():713-21.
1982: Goldstein J L; Anderson R G; Brown M S
Receptor-mediated endocytosis and the cellular uptake of low density lipoprotein.
Ciba Foundation symposium 1982;(92):77-95.
1981: Basu S K; Brown M S; Ho Y K; Havel R J; Goldstein J L
Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(12):7545-9.
1981: Beisiegel U; Schneider W J; Goldstein J L; Anderson R G; Brown M S
Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.
The Journal of biological chemistry 1981;256(22):11923-31.
1981: Schneider W J; Kovanen P T; Brown M S; Goldstein J L; Utermann G; Weber W; Havel R J; Kotite L; Kane J P; Innerarity T L; Mahley R W
Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.
The Journal of clinical investigation 1981;68(4):1075-85.
1981: Mosley S T; Goldstein J L; Brown M S; Falck J R; Anderson R G
Targeted killing of cultured cells by receptor-dependent photosensitization.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(9):5717-21.
1981: Krieger M; Brown M S; Goldstein J L
Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein.
Journal of molecular biology 1981;150(2):167-84.
1981: Brown M S; Goldstein J L
Lowering plasma cholesterol by raising LDL receptors.
The New England journal of medicine 1981;305(9):515-7.
1981: Goldstein J L; Hoff H F; Ho Y K; Basu S K; Brown M S
Stimulation of cholesteryl ester synthesis in macrophages by extracts of atherosclerotic human aortas and complexes of albumin/cholesteryl esters.
Arteriosclerosis (Dallas, Tex.) 1981;1(3):210-26.
1981: Basu S K; Goldstein J L; Anderson R G; Brown M S
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts.
Cell 1981;24(2):493-502.
1981: Kita T; Beisiegel U; Goldstein J L; Schneider W J; Brown M S
Antibody against low density lipoprotein receptor blocks uptake of low density lipoprotein (but not high density lipoprotein) by the adrenal gland of the mouse in vivo.
The Journal of biological chemistry 1981;256(10):4701-3.
1981: Brown M S; Kovanen P T; Goldstein J L
Regulation of plasma cholesterol by lipoprotein receptors.
Science (New York, N.Y.) 1981;212(4495):628-35.
1981: Kita T; Brown M S; Watanabe Y; Goldstein J L
Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(4):2268-72.
1981: Beisiegel U; Kita T; Anderson R G; Schneider W J; Brown M S; Goldstein J L
Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver.
The Journal of biological chemistry 1981;256(8):4071-8.
1981: Kovanen P T; Brown M S; Basu S K; Bilheimer D W; Goldstein J L
Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(3):1396-400.
1981: Kovanen P T; Bilheimer D W; Goldstein J L; Jaramillo J J; Brown M S
Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):1194-8.
1981: Anderson R G; Brown M S; Goldstein J L
Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells.
The Journal of cell biology 1981;88(2):441-52.
1980: Schneider W J; Goldstein J L; Brown M S
Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex.
The Journal of biological chemistry 1980;255(23):11442-7.
1980: Mahley R W; Innerarity T L; Brown M S; Ho Y K; Goldstein J L
Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species.
Journal of lipid research 1980;21(8):970-80.
1980: Kita T; Brown M S; Goldstein J L
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.
The Journal of clinical investigation 1980;66(5):1094-100.
1980: Windler E E; Kovanen P T; Chao Y S; Brown M S; Havel R J; Goldstein J L
The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.
The Journal of biological chemistry 1980;255(21):10464-71.
1980: Brown M S; Ho Y K; Goldstein J L
The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.
The Journal of biological chemistry 1980;255(19):9344-52.
1980: Chen G C; Krieger M; Kane J P; Wu C S; Brown M S; Goldstein J L
beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism.
Biochemistry 1980;19(20):4706-12.
1980: Faust J R; Brown M S; Goldstein J L
Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts.
The Journal of biological chemistry 1980;255(14):6546-8.
1980: Brown M S; Goldstein J L
Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.
Journal of lipid research 1980;21(5):505-17.
1980: Mello R J; Brown M S; Goldstein J L; Anderson R G
LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment.
Cell 1980;20(3):829-37.
1980: Kovanen P T; Goldstein J L; Chappell D A; Brown M S
Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo.
The Journal of biological chemistry 1980;255(12):5591-8.
1980: Ho Y K; Brown M S; Goldstein J L
Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents.
Journal of lipid research 1980;21(4):391-8.
1980: Krieger M; Peterson J; Goldstein J L; Brown M S
Mobility of apolar lipids of reconstituted low density lipoprotein as monitored by electron spin resonance spectroscopy.
The Journal of biological chemistry 1980;255(8):3330-3.
1980: Goldstein J L; Ho Y K; Brown M S; Innerarity T L; Mahley R W
Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.
The Journal of biological chemistry 1980;255(5):1839-48.
1980: Brown M S; Kovanen P T; Goldstein J L
Evolution of the LDL receptor concept-from cultured cells to intact animals.
Annals of the New York Academy of Sciences 1980;348():48-68.
1980: Anderson R G; Goldstein J L; Brown M S
Fluorescence visualization of receptor-bound low density lipoprotein in human fibroblasts.
Journal of receptor research 1980;1(1):17-39.
1980: Brown M S; Basu S K; Falck J R; Ho Y K; Goldstein J L
The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages.
Journal of supramolecular structure 1980;13(1):67-81.
1979: Schneider W J; Basu S K; McPhaul M J; Goldstein J L; Brown M S
Solubilization of the low density lipoprotein receptor.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(11):5577-81.
1979: Kovanen P T; Brown M S; Goldstein J L
Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.
The Journal of biological chemistry 1979;254(22):11367-73.
1979: Faust J R; Goldstein J L; Brown M S
Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(10):5018-22.
1979: Brown M S; Goldstein J L; Krieger M; Ho Y K; Anderson R G
Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins.
The Journal of cell biology 1979;82(3):597-613.
1979: Basu S K; Brown M S; Ho Y K; Goldstein J L
Degradation of low density lipoprotein . dextran sulfate complexes associated with deposition of cholesteryl esters in mouse macrophages.
The Journal of biological chemistry 1979;254(15):7141-6.
1979: Brown M S; Goldstein J L
Receptor-mediated endocytosis: insights from the lipoprotein receptor system.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(7):3330-7.
1979: Brown M S; Goldstein J L; Dietschy J M
Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.
The Journal of biological chemistry 1979;254(12):5144-9.
1979: Goldstein J L; Brown M S; Krieger M; Anderson R G; Mintz B
Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(6):2843-7.
1979: Goldstein J L; Anderson R G; Brown M S
Coated pits, coated vesicles, and receptor-mediated endocytosis.
Nature 1979;279(5715):679-85.
1979: Kovanen P T; Schneider W J; Hillman G M; Goldstein J L; Brown M S
Separate mechanisms for the uptake of high and low density lipoproteins by mouse adrenal gland in vivo.
The Journal of biological chemistry 1979;254(12):5498-505.
1979: Goldstein J L; Helgeson J A; Brown M S
Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.
The Journal of biological chemistry 1979;254(12):5403-9.
1979: Carpentier J L; Gorden P; Goldstein J L; Anderson R G; Brown M S; Orci L
Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study.
Experimental cell research 1979;121(1):135-42.
1979: Krieger M; McPhaul M J; Goldstein J L; Brown M S
Replacement of neutral lipids of low density lipoprotein with esters of long chain unsaturated fatty acids.
The Journal of biological chemistry 1979;254(10):3845-53.
1979: Kovanen P T; Basu S K; Goldstein J L; Brown M S
Low density lipoprotein receptors in bovine adrenal cortex. II. Low density lipoprotein binding to membranes prepared from fresh tissue.
Endocrinology 1979;104(3):610-6.
1979: Kovanen P T; Faust J R; Brown M S; Goldstein J L
Low density lipoprotein receptors in bovine adrenal cortex. I. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells.
Endocrinology 1979;104(3):599-609.
1979: Faust J R; Goldstein J L; Brown M S
Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway.
Archives of biochemistry and biophysics 1979;192(1):86-99.
1979: Goldstein J L; Ho Y K; Basu S K; Brown M S
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(1):333-7.
1979: Brown M S; Goldstein J L
Familial hypercholesterolemia: model for genetic receptor disease.
Harvey lectures 1979;73():163-201.
1979: Goldstein J L; Brown M S
The LDL receptor locus and the genetics of familial hypercholesterolemia.
Annual review of genetics 1979;13():259-89.
1979: Brown M S; Goldstein J L
Human mutations affecting the low density lipoprotein pathway.
Current concepts in nutrition 1979;8():173-8.
1979: Brown M S; Kovanen P T; Goldstein J L
Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex.
Recent progress in hormone research 1979;35():215-57.
1979: Krieger M; Smith L C; Anderson R G; Goldstein J L; Kao Y J; Pownall H J; Gotto A M; Brown M S
Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells.
Journal of supramolecular structure 1979;10(4):467-78.
1978: Ho Y K; Smith R G; Brown M S; Goldstein J L
Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells.
Blood 1978;52(6):1099-114.
1978: Anderson R G; Vasile E; Mello R J; Brown M S; Goldstein J L
Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution.
Cell 1978;15(3):919-33.
1978: Krieger M; Goldstein J L; Brown M S
Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(10):5052-6.
1978: Kovanen P T; Goldstein J L; Brown M S
High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit.
The Journal of biological chemistry 1978;253(14):5126-32.
1978: Goldstein J L; Brown M S
Familial hypercholesterolemia: pathogenesis of a receptor disease.
The Johns Hopkins medical journal 1978;143(1):8-16.
1978: Krieger M; Brown M S; Faust J R; Goldstein J L
Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle.
The Journal of biological chemistry 1978;253(12):4093-101.
1978: Basu S K; Goldstein J L; Brown M S
Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.
The Journal of biological chemistry 1978;253(11):3852-6.
1978: Goldstein J L; Faust J R; Dygos J H; Chorvat R J; Brown M S
Inhibition of cholesteryl ester formation in human fibroblasts by an analogue of 7-ketocholesterol and by progesterone.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(4):1877-81.
1978: Orci L; Carpentier J L; Perrelet A; Anderson R G; Goldstein J L; Brown M S
Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching.
Experimental cell research 1978;113(1):1-13.
1978: Fishman P H; Bradley R M; Brown M S; Faust J R; Goldstein J L
Similar content of phospholipids and gangliosides in normal and homozygous familial hypercholesterolemia fibroblasts.
Journal of lipid research 1978;19(3):304-8.
1978: Bilheimer D W; Ho Y K; Brown M S; Anderson R G; Goldstein J L
Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia.
The Journal of clinical investigation 1978;61(3):678-96.
1978: Brown M S; Kovanen P T; Goldstein J L; Eeckels R; Vandenberghe K; van den Berghe H; Fryns J P; Cassiman J J
Prenatal diagnosis of homozygous familial hypercholesterolaemia. Expression of a genetic receptor disease in utero.
Lancet 1978;1(8063):526-9.
1978: Brown M S; Faust J R; Goldstein J L; Kaneko I; Endo A
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase.
The Journal of biological chemistry 1978;253(4):1121-8.
1978: Reichl D; Myant N B; Brown M S; Goldstein J L
Biologically active low density lipoprotein in human peripheral lymph.
The Journal of clinical investigation 1978;61(1):64-71.
1978: Brown M S; Deuel T F; Basu S K; Goldstein J L
Inhibition of the binding of low-density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins.
Journal of supramolecular structure 1978;8(3):223-34.
1977: Anderson R G; Goldstein J L; Brown M S
A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts.
Nature 1977;270(5639):695-9.
1977: Goldstein J L; Brown M S; Stone N J
Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic.
Cell 1977;12(3):629-41.
1977: Goldstein J L; Brown M S
Atherosclerosis: the low-density lipoprotein receptor hypothesis.
Metabolism: clinical and experimental 1977;26(11):1257-75.
1977: Basu S K; Anderson R G; Goldstein J L; Brown M S
Metabolism of cationized lipoproteins by human fibroblasts. Biochemical and morphologic correlations.
The Journal of cell biology 1977;74(1):119-35.
1977: Faust J R; Goldstein J L; Brown M S
Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.
The Journal of biological chemistry 1977;252(14):4861-71.
1977: Brown M S; Goldstein J L
Human mutations affecting the low density lipoprotein pathway.
The American journal of clinical nutrition 1977;30(6):975-8.
1977: Ho Y K; Faust J R; Bilheimer D W; Brown M S; Goldstein J L
Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes. Comparison of cells from normal subjects and patients with homozygous familial hypercholesterolemia and abetalipoproteinemia.
The Journal of experimental medicine 1977;145(6):1531-49.
1977: Goldstein J L; Anderson R G; Buja L M; Basu S K; Brown M S
Overloading human aortic smooth muscle cells with low density lipoprotein-cholesteryl esters reproduces features of atherosclerosis in vitro.
The Journal of clinical investigation 1977;59(6):1196-202.
1977: Balasubramaniam S; Goldstein J L; Brown M S
Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(4):1421-5.
1977: Anderson R G; Brown M S; Goldstein J L
Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts.
Cell 1977;10(3):351-64.
1977: Balasubramaniam S; Goldstein J L; Faust J R; Brunschede G Y; Brown M S
Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat.
The Journal of biological chemistry 1977;252(5):1771-9.
1977: Dana S E; Brown M S; Goldstein J L
Specific, saturable, and high affinity binding of 125I-low density lipoprotein to glass beads.
Biochemical and biophysical research communications 1977;74(4):1369-76.
1977: Brown M S; Goldstein J L
Familial hypercholesterolemia: unraveling a genetic receptor disease.
Transactions of the Association of American Physicians 1977;90():91-108.
1977: Goldstein J L; Brown M S
The low-density lipoprotein pathway and its relation to atherosclerosis.
Annual review of biochemistry 1977;46():897-930.
1977: Brown M S; Anderson R G; Goldstein J L
Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells.
Journal of supramolecular structure 1977;6(1):85-94.
1976: Brown M S; Goldstein J L
Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein.
Cell 1976;9(4 PT 2):663-74.
1976: Ho Y K; Brown S; Bilheimer D W; Goldstein J L
Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.
The Journal of clinical investigation 1976;58(6):1465-74.
1976: Goldstein J L; Sobhani M K; Faust J R; Brown M S
Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus.
Cell 1976;9(2):195-203.
1976: Basu S K; Goldstein J L; Anderson G W; Brown M S
Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(9):3178-82.
1976: Balasubramaniam S; Goldstein J L; Faust J R; Brown M S
Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(8):2564-8.
1976: Ho Y K; Brown M S; Kayden H J; Goldstein J L
Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia.
The Journal of experimental medicine 1976;144(2):444-55.
1976: Anderson R G; Goldstein J L; Brown M S
Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(7):2434-8.
1976: Brown M S; Sobhani M K; Brunschede G Y; Goldstein J L
Restoration of a regulatory response to low density lipoprotein in acid lipase-deficient human fibroblasts.
The Journal of biological chemistry 1976;251(11):3277-86.
1976: Brown M S; Goldstein J L
Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor.
The New England journal of medicine 1976;294(25):1386-90.
1976: Bersot T P; Mahley R W; Brown M S; Goldstein J L
Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.
The Journal of biological chemistry 1976;251(8):2395-8.
1976: Goldstein J L; Basu S K; Brunschede G Y; Brown M S
Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans.
Cell 1976;7(1):85-95.
1976: Brown M S; Goldstein J L
Receptor-mediated control of cholesterol metabolism.
Science (New York, N.Y.) 1976;191(4223):150-4.
1976: Brown M S; Ho Y K; Goldstein J L
The low-density lipoprotein pathway in human fibroblasts: relation between cell surface receptor binding and endocytosis of low-density lipoprotein.
Annals of the New York Academy of Sciences 1976;275():244-57.
1976: Goldstein J L; Brown M S
The LDL pathway in human fibroblasts: a receptor-mediated mechanism for the regulation of cholesterol metabolism.
Current topics in cellular regulation 1976;11():147-81.
1976: Brown M S; Goldstein J L
New directions in human biochemical genetics: understanding the manifestations of receptor deficiency states.
Progress in medical genetics 1976;1():103-19.
1975: Bilheimer D W; Goldstein J L; Grundy S M; Brown M S
Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.
The Journal of clinical investigation 1975;56(6):1420-30.
1975: Brown M S; Goldstein J L
Regulation of the activity of the low density lipoprotein receptor in human fibroblasts.
Cell 1975;6(3):307-16.
1975: Goldstein J L; Dana S E; Faust J R; Beaudet A L; Brown M S
Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.
The Journal of biological chemistry 1975;250(21):8487-95.
1975: Goldstein J L; Brunschede G Y; Brown M S
Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.
The Journal of biological chemistry 1975;250(19):7854-62.
1975: Harrod M J; Brown M S; Weinberg A G; Harkness W N; Goldstein J L
Familial pseudomembranous colitis and its relation to lincomycin therapy.
The American journal of digestive diseases 1975;20(9):808-12.
1975: Brown M S; Dana S E; Goldstein J L
Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(8):2925-9.
1975: Brown M S; Goldstein J L
Lipoprotein receptors and genetic control of cholesterol metabolism in cultured human cells.
Die Naturwissenschaften 1975;62(8):385-9.
1975: Brown M S; Dana S E; Goldstein J L
Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.
The Journal of biological chemistry 1975;250(10):4025-7.
1975: Brown M S; Brunschede G Y; Goldstein J L
Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.
The Journal of biological chemistry 1975;250(7):2502-9.
1975: Brown M S; Faust J R; Goldstein J L
Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.
The Journal of clinical investigation 1975;55(4):783-93.
1975: Brown M S; Brannan P G; Bohmfalk H A; Brunschede G Y; Dana S E; Helgeson J; Goldstein J L
Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells.
Journal of cellular physiology 1975;85(2 Pt 2 Suppl 1):425-36.
1975: Goldstein J L; Brown M S
Lipoprotein receptors, cholesterol metabolism, and atherosclerosis.
Archives of pathology 1975;99(4):181-4.
1975: Goldstein J L; Dana S E; Brunschede G Y; Brown M S
Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(3):1092-6.
1975: Goldstein J L; Brown M S
Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism.
The American journal of medicine 1975;58(2):147-50.
1975: Brannan P G; Goldstein J L; Brown M S
3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots.
Journal of lipid research 1975;16(1):7-11.
1975: Goldstein J L; Brown M S
Hyperlipidemia in coronary heart disease: a biochemical genetic approach.
The Journal of laboratory and clinical medicine 1975;85(1):15-25.
1975: Brown M S; Goldstein J L
Familial hypercholesterolemia: genetic, biochemical and pathophysiologic considerations.
Advances in internal medicine 1975;20():273-96.
1975: Goldstein J L; Brown M S; Greene A E; Coriell L L
Homozygous familial hypercholesterolemia (receptor-negative type). Repository identification No. GM-361.
Cytogenetics and cell genetics 1975;15(5):357-9.
1975: Goldstein J L; Faust J R; Brunschede G Y; Brown M S
Steroid requirements for suppression of HMG CoA reductase activity in cultured human fibroblasts.
Advances in experimental medicine and biology 1975;63():77-84.
1974: Goldstein J L; Albers J J; Schrott H G; Hazzard W R; Bierman E L; Motulsky A G
Plasma lipid levels and coronary heart disease in adult relatives of newborns with normal and elevated cord blood lipids.
American journal of human genetics 1974;26(6):727-35.
1974: Brown M S; Goldstein J L
Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol.
The Journal of biological chemistry 1974;249(22):7306-14.
1974: Goldstein J L; Dana S E; Brown M S
Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(11):4288-92.
1974: Luskey K L; Brown M S; Goldstein J L
Stimulation of the synthesis of very low density lipoproteins in rooster liver by estradiol.
The Journal of biological chemistry 1974;249(18):5939-47.
1974: Goldstein J L; Brown M S
Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.
The Journal of biological chemistry 1974;249(16):5153-62.
1974: Brown M S; Goldstein J L
Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man.
Science (New York, N.Y.) 1974;185(4145):61-3.
1974: Goldstein J L; Harrod M J; Brown M S
Homozygous familial hypercholesterolemia: specificity of the biochemical defect in cultured cells and feasibility of prenatal detection.
American journal of human genetics 1974;26(2):199-206.
1974: Brown M S; Goldstein J L
Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(3):788-92.
1974: Brown M S; Dana S E; Goldstein J L
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.
The Journal of biological chemistry 1974;249(3):789-96.
1974: Goldstein J L; Brown M S
Expression of the familial hypercholesterolemia gene in heterozygotes: model for a dominant disorder in man.
Transactions of the Association of American Physicians 1974;87():120-31.
1973: Brown M S; Goldstein J L; Siperstein M D
Regulation of cholesterol synthesis in normal and malignant tissue.
Federation proceedings 1973;32(12):2168-73.
1973: Goldstein J L; Brown M S
Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(10):2804-8.
1973: Goldstein J L; Schrott H G; Hazzard W R; Bierman E L; Motulsky A G
Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.
The Journal of clinical investigation 1973;52(7):1544-68.
1973: Goldstein J L; Hazzard W R; Schrott H G; Bierman E L; Motulsky A G
Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction.
The Journal of clinical investigation 1973;52(7):1533-43.
1973: Brown M S; Dana S E; Goldstein J L
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(7):2162-6.
1973: Hazzard W R; Goldstein J L; Schrott M G; Motulsky A G; Bierman E L
Hyperlipidemia in coronary heart disease. 3. Evaluation of lipoprotein phenotypes of 156 genetically defined survivors of myocardial infarction.
The Journal of clinical investigation 1973;52(7):1569-77.
1973: Gartler S M; Campbell B K; Goldstein J L
Cystathionine synthase activity in human leukocyte cultures.
Birth defects original article series 1973;9(1):155-9.
1972: Schrott H G; Goldstein J L; Hazzard W R; McGoodwin M M; Motulsky A G
Familial hypercholesterolemia in a large indred. Evidence for a monogenic mechanism.
Annals of internal medicine 1972;76(5):711-20.
1972: Goldstein J L; Campbell B K; Gartler S M
Cystathionine synthase activity in human lymphocytes: induction by phytohemagglutinin.
The Journal of clinical investigation 1972;51(4):1034-7.
1972: Goldstein J L; Hazzard W R; Schrott H G; Bierman E L; Motulsky A G
Genetics of hyperlipidemia in coronary heart disease.
Transactions of the Association of American Physicians 1972;85():120-38.

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