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Thomas Goldsworthy

Research Profile

Living Beings

Anatomy

Livers

Physiology

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Liver Neoplasms, Experimental

Chemicals & Drugs

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Gasoline

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Publications

TOP 3
Gregory L Kedderis; Amy R Elmore; Eric A Crecelius; Janice W Yager; Thomas L Goldsworthy
Kinetics of arsenic methylation by freshly isolated B6C3F1 mouse hepatocytes.
Andrew Suttie; Gregg E Dinse; Abraham Nyska; Glenda J Moser; Thomas L Goldsworthy; Robert R Maronpot
An investigation of the effects of late-onset dietary restriction on prostate cancer development in the TRAMP mouse.
Yukio Yamamoto; Rick Moore; Thomas L Goldsworthy; Masahiko Negishi; Robert R Maronpot
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.

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All Publications

2006: Gregory L Kedderis; Amy R Elmore; Eric A Crecelius; Janice W Yager; Thomas L Goldsworthy
Kinetics of arsenic methylation by freshly isolated B6C3F1 mouse hepatocytes.
Chemico-biological interactions 2006;161(2):139-45.
2005: Andrew Suttie; Gregg E Dinse; Abraham Nyska; Glenda J Moser; Thomas L Goldsworthy; Robert R Maronpot
An investigation of the effects of late-onset dietary restriction on prostate cancer development in the TRAMP mouse.
Toxicologic pathology 2005;33(3):386-97.
2004: Yukio Yamamoto; Rick Moore; Thomas L Goldsworthy; Masahiko Negishi; Robert R Maronpot
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.
Cancer research 2004;64(20):7197-200.
2004: Maria T Gallardo-Williams; Robert Chapin; Paula E King; Glenda J Moser; Thomas L Goldsworthy; James P Morrison; Robert R Maronpot
Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice.
Toxicologic pathology 2004;32(1):73-8.
2003: Abraham Nyska; Andrew Suttie; Shlomo Bakshi; Liat Lomnitski; Shlomo Grossman; Margalit Bergman; Varda Ben-Shaul; Patrick Crocket; Joseph K Haseman; Glenda J Moser; Thomas L Goldsworthy; Robert R Maronpot
Slowing tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural anti-oxidant from spinach, NAO--a comparative study of three anti-oxidants.
Toxicologic pathology 2003;31(1):39-51.
2003: Andrew Suttie; Abraham Nyska; Joseph K Haseman; Glenda J Moser; Theleria R Hackett; Thomas L Goldsworthy
A grading scheme for the assessment of proliferative lesions of the mouse prostate in the TRAMP model.
Toxicologic pathology 2003;31(1):31-8.
2002: Thomas L Goldsworthy; Ronny Fransson-Steen
Quantitation of the cancer process in C57BL/6J, B6C3F1 and C3H/HeJ mice.
Toxicologic pathology 2002;30(1):97-105.
2001: Abraham Nyska; Liat Lomnitski; Judson W Spalding; David B Dunson; Thomas L Goldsworthy; Varda Ben-Shaul; Shlomo Grossman; Margalit Bergman; Gary A Boorman
Topical and oral administration of the natural water-soluble antioxidant from spinach reduces the multiplicity of papillomas in the Tg.AC mouse model.
Toxicology letters 2001;122(1):33-44.
2000: Douglas Wolf; Thomas L Goldsworthy; Derek B Janszen; R Harden; EM Donner; C S David; Jeffrey I Everitt
Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats.
Carcinogenesis 2000;21(8):1553-8.
1999: JG Christensen; Thomas L Goldsworthy; Russell C Cattley
Dysregulation of apoptosis by c-myc in transgenic hepatocytes and effects of growth factors and nongenotoxic carcinogens.
Molecular carcinogenesis 1999;25(4):273-84.
1999: JG Christensen; Elizabeth H Romach; LN Healy; AJ Gonzales; Anderson Steven; D E Malarkey; J Christopher Corton; TR Fox; Russell C Cattley; Thomas L Goldsworthy
Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.
Carcinogenesis 1999;20(8):1583-90.
1998: Douglas Wolf; Thomas L Goldsworthy; EM Donner; R Harden; B Fitzpatrick; Jeffrey I Everitt
Estrogen treatment enhances hereditary renal tumor development in Eker rats.
Carcinogenesis 1998;19(11):2043-7.
1998: JG Christensen; AJ Gonzales; Russell C Cattley; Thomas L Goldsworthy
Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(9):815-25.
1998: AJ Gonzales; JG Christensen; R J Preston; Thomas L Goldsworthy; T D Tlsty; TR Fox
Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital.
Carcinogenesis 1998;19(7):1173-83.
1998: AJ Gonzales; Thomas L Goldsworthy; TR Fox
Chemical transformation of mouse liver cells results in altered cyclin D-CDK protein complexes.
Carcinogenesis 1998;19(6):1093-102.
1998: Glenda J Moser; Douglas Wolf; Madhabananda Sar; Kevin W Gaido; Derek B Janszen; Thomas L Goldsworthy
Methyl tertiary butyl ether-induced endocrine alterations in mice are not mediated through the estrogen receptor.
Toxicological sciences : an official journal of the Society of Toxicology 1998;41(1):77-87.
1997: P M Fernandez; Linda Pluta; Ronny Fransson-Steen; Thomas L Goldsworthy; TR Fox
Reverse transcription-polymerase chain reaction-based methodology to quantify differential gene expression directly from microdissected regions of frozen tissue sections.
Molecular carcinogenesis 1997;20(3):317-26.
1997: Glenda J Moser; Douglas Wolf; Thomas L Goldsworthy
Quantitative relationship between transforming growth factor-alpha and hepatic focal phenotype and progression in female mouse liver.
Toxicologic pathology 1997;25(3):275-83.
1997: Elizabeth H Romach; Thomas L Goldsworthy; Robert R Maronpot; TR Fox
Altered gene expression in spontaneous hepatocellular carcinomas from male B6C3F1 mice.
Molecular carcinogenesis 1997;19(1):31-8.
1997: Glenda J Moser; Douglas Wolf; Brian A Wong; Thomas L Goldsworthy
Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
Carcinogenesis 1997;18(5):1075-83.
1997: Ronny Fransson-Steen; Thomas L Goldsworthy; Gregory L Kedderis; Robert R Maronpot
Furan-induced liver cell proliferation and apoptosis in female B6C3F1 mice.
Toxicology 1997;118(2-3):195-204.
1997: TR Fox; P J McMillen; Robert R Maronpot; Thomas L Goldsworthy
Genomic instability, as measured by microsatellite alterations, is not associated with liver tumor development in the genetically susceptible B6C3F1 mouse.
Toxicology and applied pharmacology 1997;143(1):167-72.
1996: Glenda J Moser; Brian A Wong; Douglas Wolf; Ronny Fransson-Steen; Thomas L Goldsworthy
Methyl tertiary butyl ether lacks tumor-promoting activity in N-nitrosodiethylamine-initiated B6C3F1 female mouse liver.
Carcinogenesis 1996;17(12):2753-61.
1996: Thomas L Goldsworthy; Rory B Conolly; Ronny Fransson-Steen
Apoptosis and cancer risk assessment.
Mutation research 1996;365(1-3):71-90.
1996: Glenda J Moser; Douglas Wolf; R Harden; A M Standeven; J Mills; R L Jirtle; Thomas L Goldsworthy
Cell proliferation and regulation of negative growth factors in mouse liver foci.
Carcinogenesis 1996;17(9):1835-40.
1996: Glenda J Moser; Brian A Wong; Douglas Wolf; W R Moss; Thomas L Goldsworthy
Comparative short-term effects of methyl tertiary butyl ether and unleaded gasoline vapor in female B6C3F1 mice.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;31(2):173-83.
1996: Thomas L Goldsworthy; Ronny Fransson-Steen; R R Maronpot
Importance of and approaches to quantification of hepatocyte apoptosis.
Toxicologic pathology 1996;24(1):24-35.
1995: Robert R Maronpot; T Fox; David E Malarkey; Thomas L Goldsworthy
Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors.
Toxicology 1995;101(3):125-56.
1995: J W Bauman; Thomas L Goldsworthy; C S Dunn; TR Fox
Inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on rat hepatocyte proliferation induced by 2/3 partial hepatectomy.
Cell proliferation 1995;28(8):437-51.
1995: A M Standeven; Douglas Wolf; Thomas L Goldsworthy
Promotion of hepatic preneoplastic lesions in male B6C3F1 mice by unleaded gasoline.
Environmental health perspectives 1995;103(7-8):696-700.
1995: G Horesovsky; Leslie Recio; Jeffrey I Everitt; Thomas L Goldsworthy; Douglas Wolf; C Walker
p53 status in spontaneous and dimethylnitrosamine-induced renal cell tumors from rats.
Molecular carcinogenesis 1995;12(4):236-40.
1994: A M Standeven; Thomas L Goldsworthy
Identification of hepatic mitogenic and cytochrome P-450-inducing fractions of unleaded gasoline in B6C3F1 mice.
Journal of toxicology and environmental health 1994;43(2):213-24.
1994: A M Standeven; D G Blazer; Thomas L Goldsworthy
Investigation of antiestrogenic properties of unleaded gasoline in female mice.
Toxicology and applied pharmacology 1994;127(2):233-40.
1994: Thomas L Goldsworthy; S M Goldsworthy; C S Sprankle; Byron E Butterworth
Expression of myc, fos and Ha-ras associated with chemically induced cell proliferation in the rat liver.
Cell proliferation 1994;27(5):269-78.
1994: A M Standeven; Douglas Wolf; Thomas L Goldsworthy
Interactive effects of unleaded gasoline and estrogen on liver tumor promotion in female B6C3F1 mice.
Cancer research 1994;54(5):1198-204.
1994: Byron E Butterworth; C S Sprankle; S M Goldsworthy; D M Wilson; Thomas L Goldsworthy
Expression of myc, fos, and Ha-ras in the livers of furan-treated F344 rats and B6C3F1 mice.
Molecular carcinogenesis 1994;9(1):24-32.
1994: Melvin Andersen; J J Mills; TR Fox; Thomas L Goldsworthy; Rory B Conolly; Linda S Birnbaum
Receptor-mediated toxicity and implications for risk assessment.
Progress in clinical and biological research 1994;387():295-310.
1994: Thomas L Goldsworthy; Leslie Recio; K Brown; L A Donehower; J C Mirsalis; R W Tennant; I F Purchase
Transgenic animals in toxicology.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1994;22(1):8-19.
1993: Robert R Maronpot; Julie F Foley; K Takahashi; Thomas L Goldsworthy; G Clark; A Tritscher; C Portier; George W Lucier
Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.
Environmental health perspectives 1993;101(7):634-42.
1993: Thomas L Goldsworthy; B E Butterworth; R R Maronpot
Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis.
Environmental health perspectives 1993;101 Suppl 5():59-65.
1993: J Foley; T Ton; Robert R Maronpot; B Butterworth; Thomas L Goldsworthy
Comparison of proliferating cell nuclear antigen to tritiated thymidine as a marker of proliferating hepatocytes in rats.
Environmental health perspectives 1993;101 Suppl 5():199-205.
1993: S M Goldsworthy; Thomas L Goldsworthy; C S Sprankle; Byron E Butterworth
Variation in expression of genes used for normalization of Northern blots after induction of cell proliferation.
Cell proliferation 1993;26(6):511-8.
1993: A M Standeven; Thomas L Goldsworthy
Promotion of preneoplastic lesions and induction of CYP2B by unleaded gasoline vapor in female B6C3F1 mouse liver.
Carcinogenesis 1993;14(10):2137-41.
1993: TR Fox; L L Best; S M Goldsworthy; J J Mills; Thomas L Goldsworthy
Gene expression and cell proliferation in rat liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.
Cancer research 1993;53(10 Suppl):2265-71.
1993: Lorraine Tilbury; B E Butterworth; O Moss; Thomas L Goldsworthy
Hepatocyte cell proliferation in mice after inhalation exposure to unleaded gasoline vapor.
Journal of toxicology and environmental health 1993;38(3):293-307.
1992: Jeffrey I Everitt; Thomas L Goldsworthy; Douglas Wolf; Cheryl Lyn Walker
Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome.
The Journal of urology 1992;148(6):1932-6.
1992: D S Marsman; Thomas L Goldsworthy; J A Popp
Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acid.
Carcinogenesis 1992;13(6):1011-7.
1992: C Walker; Thomas L Goldsworthy; Douglas Wolf; Jeffrey I Everitt
Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.
Science (New York, N.Y.) 1992;255(5052):1693-5.
1992: S R Eldridge; Thomas L Goldsworthy; J A Popp; Byron E Butterworth
Mitogenic stimulation of hepatocellular proliferation in rodents following 1,4-dichlorobenzene administration.
Carcinogenesis 1992;13(3):409-15.
1992: D M Wilson; Thomas L Goldsworthy; J A Popp; Byron E Butterworth
Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan.
Environmental and molecular mutagenesis 1992;19(3):209-22.
1991: George W Lucier; A Tritscher; Thomas L Goldsworthy; J Foley; G Clark; J Goldstein; Robert R Maronpot
Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.
Cancer research 1991;51(5):1391-7.
1990: S R Eldridge; Lorraine Tilbury; Thomas L Goldsworthy; Byron E Butterworth
Measurement of chemically induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2'-deoxyuridine and [3H]thymidine administered by injection or osmotic pump.
Carcinogenesis 1990;11(12):2245-51.