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Douglas Golenbock

Research Profile

Chemicals & Drugs

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Signal Transduction

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Donghai Wang; Umtul M Ahmad; Katherine A Fitzgerald; Susanne Höing; Heide Christine Patterson; Klaus Rajewsky; Vijay A K Rathinam; Douglas T Golenbock
Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Arnaud Firon; Philippe Glaser; Douglas T Golenbock; Claire Poyart; Elisabeth Sauvage; Asmaa Tazi; Sophie Brinster; Violette Da Cunha; Shaynoor Dramsi; Patrick Trieu-Cuot
The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus.
Michael T Heneka; Martin Korte; Markus P Kummer; Eicke Latz; Anita Remus; Stephanie Schwartz; Andrea Stutz; Te-Chen Tzeng; Ana Vieira-Saecker; Daisy Axt; Andrea Delekate; Ellen Gelpi; Angelika Griep; Annett Halle; Douglas T Golenbock
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.

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2013: Donghai Wang; Umtul M Ahmad; Katherine A Fitzgerald; Susanne Höing; Heide Christine Patterson; Klaus Rajewsky; Vijay A K Rathinam; Douglas T Golenbock
Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
The Journal of biological chemistry 2013;288(7):4594-601.
2013: Arnaud Firon; Philippe Glaser; Douglas T Golenbock; Claire Poyart; Elisabeth Sauvage; Asmaa Tazi; Sophie Brinster; Violette Da Cunha; Shaynoor Dramsi; Patrick Trieu-Cuot
The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus.
PLoS pathogens 2013;9(2):e1003179.
2013: Michael T Heneka; Martin Korte; Markus P Kummer; Eicke Latz; Anita Remus; Stephanie Schwartz; Andrea Stutz; Te-Chen Tzeng; Ana Vieira-Saecker; Daisy Axt; Andrea Delekate; Ellen Gelpi; Angelika Griep; Annett Halle; Douglas T Golenbock
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Nature 2013;493(7434):674-8.
2013: Alan Basset; Cyril Benes; Andrew Camilli; Douglas T Golenbock; Muriel Herd; Sabina Sayeed; Claudette Thompson; Fan Zhang; Richard Malley
Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
The Journal of biological chemistry 2013;288(4):2665-75.
2013: Warrison A Andrade; Daniella C Bartholomeu; Miriam S Dutra; Sankar Ghosh; Douglas T Golenbock; Mariane B Melo; Kamalpreet Nagpal; Espiridion Ramos-Martinez; Maria do Carmo Souza; Ricardo T Gazzinelli
Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
Cell host & microbe 2013;13(1):42-53.
2012: Stuart M Levitz; Douglas T Golenbock
Beyond empiricism: informing vaccine development through innate immunity research.
Cell 2012;148(6):1284-92.
2012: Alessandro Costa; Roberta Galbo; Douglas T Golenbock; Rahul Gupta; Philipp Henneke; Antonio Malara; Giuseppe Mancuso; Angelina Midiri; Salvatore Papasergi; Giacomo Signorino; Giuseppe Teti; Patrick Trieu-Cuot; Carmelo Biondo; Francesco Cardile; Concetta Beninati
Activation of the NLRP3 inflammasome by group B streptococci.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(4):1953-60.
2012: Alejandro Ramirez; Vijay Rathinam; Katherine A Fitzgerald; Douglas T Golenbock; Anuja Mathew
Defective pro-IL-1β responses in macrophages from aged mice.
Immunity & ageing : I & A 2012;9(1):27.
2011: Jianmin Meng; Mei Gong; Harry Björkbacka; Douglas T Golenbock
Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3683-93.
2011: Shruti Sharma; Glen N Barber; Daniella C Bartholomeu; Jennie Chan; Rosane B DeOliveira; Katherine A Fitzgerald; Ricardo T Gazzinelli; Nadege Goutagny; J Perry Hall; Zhaozhao Jiang; Parisa Kalantari; Fanny Lauw; Rosane Barbosa de Oliveira; Douglas T Golenbock
Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Immunity 2011;35(2):194-207.
2011: Braulia C Caetano; Bianca B Carmo; Anna Cerny; Sara L dos Santos; Douglas T Golenbock; Mariane B Melo; Daniella C Bartholomeu; Ricardo T Gazzinelli
Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1903-11.
2011: Kamalpreet Nagpal; Theo S Plantinga; Cherilyn M Sirois; Brian G Monks; Eicke Latz; Mihai G Netea; Douglas T Golenbock
Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.
The Journal of biological chemistry 2011;286(13):11875-82.
2011: Quanshun Zhang; X Feng; W Nie; Douglas T Golenbock; Harriet Mayanja-Kizza; Saul Tzipori; Hanping Feng
MyD88-dependent pathway is essential for the innate immunity to Enterocytozoon bieneusi.
Parasite immunology 2011;33(4):217-25.
2011: James Harris; Michelle Hartman; Caitrionna Roche; Shijuan G Zeng; Amy O'Shea; Fiona A Sharp; Eimear M Lambe; Emma M Creagh; Douglas T Golenbock; Jurg Tschopp; Hardy Kornfeld; Katherine A Fitzgerald; E C Lavelle
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
The Journal of biological chemistry 2011;286(11):9587-97.
2011: Bernardo Franklin; Sally T Ishizaka; Marc Lamphier; Fabian Gusovsky; Hans Hansen; Jeffrey Rose; Wanjun Zheng; Marco Antônio Ataíde; Rosane B de Oliveira; Douglas T Golenbock; Rosane Barbosa de Oliveira
Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(9):3689-94.
2011: Sachin D Deshmukh; Bernhard Kremer; Marina Freudenberg; Stefan Bauer; Douglas T Golenbock; Philipp Henneke
Macrophages recognize streptococci through bacterial single-stranded RNA.
EMBO reports 2011;12(1):71-6.
2010: Jakub Siednienko; Annett Halle; Kamalpreet Nagpal; Douglas T Golenbock; Sinead M Miggin
TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
European journal of immunology 2010;40(11):3150-60.
2010: Tatyana Lysakova-Devine; Brian Keogh; Barry Harrington; Kamalpreet Nagpal; Annett Halle; Douglas T Golenbock; Tom Monie; Andrew G Bowie
Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4261-71.
2010: Jianmin Meng; Joshua R Drolet; Brian G Monks; Douglas T Golenbock
MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.
The Journal of biological chemistry 2010;285(36):27935-43.
2010: Jianmin Meng; Egil Lien; Douglas T Golenbock
MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
The Journal of biological chemistry 2010;285(12):8695-702.
2010: Cameron R Stewart; Lynda M Stuart; Kim Wilkinson; Janine M van Gils; Jiusheng Deng; Annett Halle; Katey J Rayner; Laurent Boyer; Ruiqin Zhong; William A Frazier; Adam Lacy-Hulbert; Joseph B El-Khoury; Douglas T Golenbock; Kathryn J Moore
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
Nature immunology 2010;11(2):155-61.
2010: Mariane B Melo; Pia Kasperkovitz; Anna Cerny; Stephanie Könen-Waisman; Evelyn A Kurt-Jones; Egil Lien; Bruce Beutler; Jonathan C Howard; Douglas T Golenbock; Ricardo T Gazzinelli
UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
PLoS pathogens 2010;6(8):e1001071.
2010: Tobias Strunk; Melanie R Power Coombs; Andrew J Currie; Peter Richmond; Douglas T Golenbock; Liat Stoler-Barak; Leighanne C Gallington; Michael Otto; David Burgner; Ofer Levy
TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia.
PloS one 2010;5(4):e10111.
2009: Victoria Auerbuch; Douglas T Golenbock; Ralph R Isberg
Innate immune recognition of Yersinia pseudotuberculosis type III secretion.
PLoS pathogens 2009;5(12):e1000686.
2009: Andrea Stutz; Douglas T Golenbock; Eicke Latz
Inflammasomes: too big to miss.
The Journal of clinical investigation 2009;119(12):3502-11.
2009: Ulf Diczfalusy; Katarina E Olofsson; Ann-Margreth Carlsson; Mei Gong; Douglas T Golenbock; Olav Rooyackers; Urban Fläring; Harry Björkbacka
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
Journal of lipid research 2009;50(11):2258-64.
2009: Kamalpreet Nagpal; Theo S Plantinga; Joyce Wong; Brian G Monks; nicholas gay; Mihai G Netea; Katherine A Fitzgerald; Douglas T Golenbock
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
The Journal of biological chemistry 2009;284(38):25742-8.
2009: Elaine F Kenny; Suzanne Talbot; Mei Gong; Douglas T Golenbock; Clare E Bryant; Luke A J O'Neill
MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3642-51.
2009: Brett Verstak; Kamalpreet Nagpal; Stephen P Bottomley; Douglas T Golenbock; Paul J Hertzog; Ashley Mansell
MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
The Journal of biological chemistry 2009;284(36):24192-203.
2009: Sandra Santos-Sierra; Sachin D Deshmukh; Julia Kalnitski; Peter Küenzi; Matthias P Wymann; Douglas T Golenbock; Philipp Henneke
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
The EMBO journal 2009;28(14):2018-27.
2009: Eva M Palsson-McDermott; Sarah L Doyle; Anne F McGettrick; Matthew Hardy; Harald Husebye; Kathy Banahan; Mei Gong; Douglas T Golenbock; Terje Espevik; Luke A J O'Neill
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
Nature immunology 2009;10(6):579-86.
2009: Sybille Kenzel; Sandra Santos-Sierra; Sachin D Deshmukh; Inga Moeller; Bilge Ergin; Katherine A Fitzgerald; Egil Lien; Shizuo Akira; Douglas T Golenbock; Philipp Henneke
Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
Infection and immunity 2009;77(6):2474-81.
2009: Bernardo Franklin; Rosane Barbosa de Oliveira; Marco Antonio Ataíde; Fanny Lauw; Catherine Ropert; Rosane B de Oliveira; Dhelio Pereira; Mauro Shugiro Tada; Paulo Nogueira; Luiz Hildebrando Pereira da Silva; Harry Bjorkbacka; Douglas T Golenbock; Ricardo T Gazzinelli
Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5789-94.
2009: Yuxian He; Sophie J Barker; Angus J MacDonald; Yu Yu; Long Cao; Jingjing Li; Ranjit Parhar; Susanne Heck; Susanne Hartmann; Douglas T Golenbock; Shibo Jiang; Nathan A Libri; Amanda E Semper; William M Rosenberg; Sara Lustigman
Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4005-16.
2009: Michael G Drage; Nicole D Pecora; Amy G Hise; Maria Febbraio; Roy L Silverstein; Douglas T Golenbock; W Henry Boom; Clifford V Harding
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Cellular immunology 2009;258(1):29-37.
2009: Øystein Sandanger; Liv Ryan; Janne Bohnhorst; Ann-Charlotte Iversen; Harald Husebye; Øyvind Halaas; Linn Landrø; Pål Aukrust; Stig S Frøland; Greg Elson; Alberto Visintin; Olav Øktedalen; Jan Kristian Damås; Anders Sundan; Douglas T Golenbock; Terje Espevik
IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):588-95.
2008: Marie Charrel-Dennis; Eicke Latz; Kristen A Halmen; Patrick Trieu-Cuot; Katherine A Fitzgerald; Dennis L Kasper; Douglas T Golenbock
TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
Cell host & microbe 2008;4(6):543-54.
2008: Annett Halle; Veit Hornung; Gabor C Petzold; Cameron R Stewart; Brian G Monks; Thomas Reinheckel; Katherine A Fitzgerald; Eicke Latz; Kathryn J Moore; Douglas T Golenbock
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Nature immunology 2008;9(8):857-65.
2008: Daniella C Bartholomeu; Catherine Ropert; Mariane B Melo; Peggy Parroche; Caroline F Junqueira; Santuza M R Teixeira; Cherilyn Sirois; Pia Kasperkovitz; Cathrine F Knetter; Egil Lien; Eicke Latz; Douglas T Golenbock; Ricardo T Gazzinelli
Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1333-44.
2008: Hidenobu Yoshioka; Atsutoshi Yoshimura; Takashi Kaneko; Douglas T Golenbock; Yoshitaka Hara
Analysis of the activity to induce toll-like receptor (TLR)2- and TLR4-mediated stimulation of supragingival plaque.
Journal of periodontology 2008;79(5):920-8.
2008: Philipp Henneke; Shaynoor Dramsi; Giuseppe Mancuso; Kamila Chraibi; Elisabeth Pellegrini; Christian Theilacker; Johannes Hübner; Sandra Santos-Sierra; Giuseppe Teti; Douglas T Golenbock; Claire Poyart; Patrick Trieu-Cuot
Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6149-58.
2008: Vishal Jain; Annett Halle; Kristen A Halmen; Egil Lien; Marie Charrel-Dennis; Sanjay Ram; Douglas T Golenbock; Alberto Visintin
Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling.
Blood 2008;111(9):4637-45.
2008: Sylvia Knapp; Sonja Von Aulock; Masja Leendertse; Isabella Haslinger; Christian Draing; Douglas T Golenbock; Tom van der Poll
Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3478-84.
2008: Keiko Ueno; Takeshi Koga; kosuke kato; Douglas T Golenbock; Sandra J Gendler; Hirofumi Kai; K. Chul Kim
MUC1 mucin is a negative regulator of toll-like receptor signaling.
American journal of respiratory cell and molecular biology 2008;38(3):263-8.
2008: Jianmin Meng; Peggy Parroche; Douglas T Golenbock; C James McKnight
The differential impact of disulfide bonds and N-linked glycosylation on the stability and function of CD14.
The Journal of biological chemistry 2008;283(6):3376-84.
2008: Shenghua Zhou; Annett Halle; Evelyn A Kurt-Jones; Anna M Cerny; Ermelinda Porpiglia; Michael Rogers; Douglas T Golenbock; Robert W Finberg
Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.
Journal of neuroimmunology 2008;194(1-2):70-82.
2008: Masataka Asagiri; Toshitake Hirai; Toshihiro Kunigami; Shunya Kamano; Hans-Jürgen Gober; Kazuo Okamoto; Keizo Nishikawa; Eicke Latz; Douglas T Golenbock; Kazuhiro Aoki; Keiichi Ohya; Yuuki Imai; Yasuyuki Morishita; Kohei Miyazono; Shigeaki Kato; Paul Saftig; Hiroshi Takayanagi
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Science (New York, N.Y.) 2008;319(5863):624-7.
2007: Sushila K Nordone; Glicerio A Ignacio; Lishan Su; Gregory D Sempowski; Douglas T Golenbock; Liwu Li; Gregg A Dean
Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation.
AIDS research and human retroviruses 2007;23(11):1387-95.
2007: Charles Sweet; Joseph Conlon; Douglas T Golenbock; Jon Goguen; Neal Silverman
YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction.
Cellular microbiology 2007;9(11):2700-15.
2007: Françoise Debierre-Grockiego; Marco A Campos; Nahid Azzouz; Jörg Schmidt; Ulrike Bieker; Marianne Garcia Resende; Daniel Santos Mansur; Ralf Weingart; Richard R Schmidt; Douglas T Golenbock; Ricardo T Gazzinelli; Ralph T Schwarz
Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1129-37.
2007: Matthew B B McCall; Mihai G Netea; Cornelus C Hermsen; Trees Jansen; Liesbeth Jacobs; Douglas T Golenbock; Andre J A M van der Ven; Robert W Sauerwein
Plasmodium falciparum infection causes proinflammatory priming of human TLR responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):162-71.
2007: Chun-Jen Chen; Hajime Kono; Douglas T Golenbock; George Reed; Shizuo Akira; Kenneth L Rock
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
Nature medicine 2007;13(7):851-6.
2007: Eicke Latz; Anjali Verma; Alberto Visintin; Mei Gong; Cherilyn M Sirois; David C Klein; Brian G Monks; C James McKnight; Marc S Lamphier; W Paul Duprex; Terje Espevik; Douglas T Golenbock
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Nature immunology 2007;8(7):772-9.
2007: Kristen R Taylor; Kenshi Yamasaki; Katherine A Radek; Anna Di Nardo; Heidi Goodarzi; Douglas T Golenbock; Bruce Beutler; Richard L Gallo
Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.
The Journal of biological chemistry 2007;282(25):18265-75.
2007: Katherine A Fitzgerald; Douglas T Golenbock
Immunology. The shape of things to come.
Science (New York, N.Y.) 2007;316(5831):1574-6.
2007: Bernardo Franklin; Soraia O Rodrigues; Lis R Antonelli; Roberta V Oliveira; Arthur M Goncalves; Policarpo A Sales-Junior; Eneida P Valente; Jacqueline I Alvarez-Leite; Catherine Ropert; Douglas T Golenbock; Ricardo T Gazzinelli
MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria.
Microbes and infection / Institut Pasteur 2007;9(7):881-90.
2007: Jane Tian; Ana Maria Avalos; Su-Yau Mao; Bo Chen; Kannaki Senthil; Herren Wu; Peggy Parroche; Stacey V Drabic; Douglas T Golenbock; Cherilyn M Sirois; Jing Hua; Ling Ling An; Laurent P Audoly; Greg La Rosa; Angelika Bierhaus; Peter Naworth; Ann Marshak-Rothstein; Mary Crow; Katherine A Fitzgerald; Eicke Latz; Peter Kiener; Anthony J Coyle
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Nature immunology 2007;8(5):487-96.
2007: Sinead M Miggin; Eva M Pålsson-McDermott; Aisling Dunne; Caroline Jefferies; Emmanuel Pinteaux; Kathy Banahan; Caroline Murphy; Paul N Moynagh; Masahiro Yamamoto; Shizuo Akira; Nancy J Rothwell; Douglas T Golenbock; Katherine A Fitzgerald; Luke A J O'Neill
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3372-7.
2007: Peggy Parroche; Fanny N Lauw; Nadege Goutagny; Eicke Latz; Brian G Monks; Alberto Visintin; Kristen A Halmen; Marc S Lamphier; Martin Olivier; Daniella C Bartholomeu; Ricardo T Gazzinelli; Douglas T Golenbock
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1919-24.
2007: Amy G Hise; Katrin Daehnel; Illona Gillette-Ferguson; Eun Cho; Helen F McGarry; Mark J Taylor; Douglas T Golenbock; Katherine A Fitzgerald; James W Kazura; Eric Pearlman
Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):1068-76.
2006: Tracie A Seimon; Amrom Obstfeld; Kathryn J Moore; Douglas T Golenbock; Ira Tabas
Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19794-9.
2006: Qun Wang; Rachel M McLoughlin; Brian A Cobb; Marie Charrel-Dennis; Kathleen J Zaleski; Douglas T Golenbock; Arthur O Tzianabos; Dennis L Kasper
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.
The Journal of experimental medicine 2006;203(13):2853-63.
2006: Alberto Visintin; Kristen A Halmen; Naseema Khan; Brian G Monks; Douglas T Golenbock; Egil Lien
MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).
Journal of leukocyte biology 2006;80(6):1584-92.
2006: Jennifer P Wang; Ping Liu; Eicke Latz; Douglas T Golenbock; Robert W Finberg; Daniel H Libraty
Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7114-21.
2006: Marc S Lamphier; Cherilyn M Sirois; Anjali Verma; Douglas T Golenbock; Eicke Latz
TLR9 and the recognition of self and non-self nucleic acids.
Annals of the New York Academy of Sciences 2006;1082():31-43.
2006: Chun-Jen Chen; Yan Shi; Arron Hearn; Kate Fitzgerald; Douglas T Golenbock; George Reed; Shizuo Akira; Kenneth L Rock
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
The Journal of clinical investigation 2006;116(8):2262-71.
2006: Man Yu; Haichao Wang; Aihao Ding; Douglas T Golenbock; Eicke Latz; Christopher Czura; Matthew J Fenton; Kevin Tracey; Huan Yang
HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
Shock (Augusta, Ga.) 2006;26(2):174-9.
2006: Seija Lehnardt; Philipp Henneke; Egil Lien; Dennis L Kasper; Joseph J Volpe; Ingo Bechmann; Robert Nitsch; Joerg R Weber; Douglas T Golenbock; Timothy Vartanian
A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):583-92.
2006: Anne F McGettrick; Elizabeth K Brint; Eva M Palsson-McDermott; Daniel Rowe; Douglas T Golenbock; nicholas gay; Katherine A Fitzgerald; Luke A J O'Neill
Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9196-201.
2006: Daniel Rowe; Anne F McGettrick; Eicke Latz; Brian G Monks; nicholas gay; Masahiro Yamamoto; Shizuo Akira; Luke A J O'Neill; Katherine A Fitzgerald; Douglas T Golenbock
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6299-304.
2006: Elke Cario; Douglas T Golenbock; Alberto Visintin; Michael Rünzi; Guido Gerken; Daniel K Podolsky
Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4258-66.
2006: Sylvia Knapp; Sandrine Florquin; Douglas T Golenbock; Tom van der Poll
Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3189-95.
2006: Sybille Kenzel; Giuseppe Mancuso; Richard Malley; Giuseppe Teti; Douglas T Golenbock; Philipp Henneke
c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3181-8.
2006: Paola Massari; Alberto Visintin; Jay Gunawardana; Kristen A Halmen; Carol A King; Douglas T Golenbock; Wetzler Lee
Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2373-80.
2006: Sandra Santos-Sierra; Douglas T Golenbock; Philipp Henneke
Toll-like receptor-dependent discrimination of streptococci.
Journal of endotoxin research 2006;12(5):307-12.
2006: Alberto Visintin; Dimitar B Iliev; Brian G Monks; Kristen A Halmen; Douglas T Golenbock
MD-2.
Immunobiology 2006;211(6-8):437-47.
2006: Mami Kishimoto; Atsutoshi Yoshimura; Mariko Naito; Kuniaki Okamoto; Kenji Yamamoto; Douglas T Golenbock; Yoshitaka Hara; Koji Nakayama
Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling.
Microbiology and immunology 2006;50(4):315-25.
2006: Kathleen A Rogers; Arlin Rogers; Brett A Leav; A Sanchez; Edouard Vannier; S Uematsu; S Akira; Douglas T Golenbock; Honorine D Ward
MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice.
Infection and immunity 2006;74(1):549-56.
2005: Paul B Mann; Daniel Wolfe; Eicke Latz; Douglas T Golenbock; Andrew Preston; Eric T Harvill
Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection.
Infection and immunity 2005;73(12):8144-52.
2005: Laszlo Romics; Angela Dolganiuc; Arumugam Velayudham; Karen Kodys; Pranoti Mandrekar; Douglas T Golenbock; Evelyn A Kurt-Jones; Gyongyi Szabo
Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
Journal of leukocyte biology 2005;78(6):1255-64.
2005: Alberto Visintin; Kristen A Halmen; Eicke Latz; Brian G Monks; Douglas T Golenbock
Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6465-72.
2005: Xin Yang; Daniel Coriolan; Kelly Schultz; Douglas T Golenbock; Debbie Beasley
Toll-like receptor 2 mediates persistent chemokine release by Chlamydia pneumoniae-infected vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(11):2308-14.
2005: Amit Srivastava; Philipp Henneke; Alberto Visintin; Sarah C Morse; Victoria Martin; Claire Watkins; James C Paton; Michael R Wessels; Douglas T Golenbock; Richard Malley
The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.
Infection and immunity 2005;73(10):6479-87.
2005: Fanny N Lauw; Daniel R Caffrey; Douglas T Golenbock
Of mice and man: TLR11 (finally) finds profilin.
Trends in immunology 2005;26(10):509-11.
2005: Xin Yang; Daniel Coriolan; Vanishree Murthy; Kelly Schultz; Douglas T Golenbock; Debbie Beasley
Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.
American journal of physiology. Heart and circulatory physiology 2005;289(3):H1069-76.
2005: Middleton Boon Hinckley; C Michael Reynolds; Anthony A Ribeiro; Sara C McGrath; Robert J Cotter; Fanny N Lauw; Douglas T Golenbock; Christian R H Raetz
A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A.
The Journal of biological chemistry 2005;280(34):30214-24.
2005: Kathy Triantafilou; George Orthopoulos; Emmanouil Vakakis; Mohamed Abd Elrahman Ahmed; Douglas T Golenbock; Philipp Lepper; Martha Triantafilou
Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent.
Cellular microbiology 2005;7(8):1117-26.
2005: Judith Branger; Jaklien C Leemans; Sandrine Florquin; Peter Speelman; Douglas T Golenbock; Tom van der Poll
Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection.
Clinical immunology (Orlando, Fla.) 2005;116(2):174-81.
2005: Senad Divanovic; Aurelien Trompette; Sowsan F Atabani; Rajat Madan; Douglas T Golenbock; Alberto Visintin; Robert W Finberg; Alexander Tarakhovsky; Stefanie N Vogel; Yasmine Belkaid; Evelyn A Kurt-Jones; Christopher L Karp
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Nature immunology 2005;6(6):571-8.
2005: Philipp Henneke; Siegfried Morath; Satoshi Uematsu; Stefan Weichert; Markus Pfitzenmaier; Osamu Takeuchi; Andrea Müller; Claire Poyart; Shizuo Akira; Reinhard Berner; Giuseppe Teti; Armin Geyer; Thomas Hartung; Patrick Trieu-Cuot; Dennis L Kasper; Douglas T Golenbock
Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6449-55.
2005: Annett Schoenemeyer; Betsy J Barnes; Margo E Mancl; Eicke Latz; Nadege Goutagny; PAULA PITHA-ROWE; Katherine A Fitzgerald; Douglas T Golenbock
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
The Journal of biological chemistry 2005;280(17):17005-12.
2005: Shenghua Zhou; Evelyn A Kurt-Jones; Leisa Mandell; Anna M Cerny; Melvin Chan; Douglas T Golenbock; Robert W Finberg
MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection.
European journal of immunology 2005;35(3):822-30.
2005: Angela C Johnson; Frederick P Heinzel; Eugenia Diaconu; Yan Sun; Amy G Hise; Douglas T Golenbock; Jonathan H Lass; Eric Pearlman
Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation.
Investigative ophthalmology & visual science 2005;46(2):589-95.
2005: Terry K Means; Eicke Latz; Fumitaka Hayashi; Mandakolathur R Murali; Douglas T Golenbock; Andrew D Luster
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
The Journal of clinical investigation 2005;115(2):407-17.
2005: Takashi Kaneko; Douglas T Golenbock; Neal Silverman
Peptidoglycan recognition by the Drosophila Imd pathway.
Journal of endotoxin research 2005;11(6):383-9.
2005: Senad Divanovic; Aurelien Trompette; Sowsan F Atabani; Rajat Madan; Douglas T Golenbock; Alberto Visintin; Robert W Finberg; Alexander Tarakhovsky; Stefanie N Vogel; Yasmine Belkaid; Evelyn A Kurt-Jones; Christopher L Karp
Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.
Journal of endotoxin research 2005;11(6):363-8.
2004: Dario S Zamboni; Marco A Campos; Ana Cláudia T Torrecilhas; Katalin Kiss; James E Samuel; Douglas T Golenbock; Fanny N Lauw; Craig R Roy; Igor Almeida; Ricardo T Gazzinelli
Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
The Journal of biological chemistry 2004;279(52):54405-15.
2004: Catharina W Wieland; Sylvia Knapp; Sandrine Florquin; Alex F de Vos; Kiyoshi Takeda; Shizuo Akira; Douglas T Golenbock; Annelies Verbon; Tom van der Poll
Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
American journal of respiratory and critical care medicine 2004;170(12):1367-74.
2004: Katherine A Fitzgerald; Daniel Rowe; Douglas T Golenbock
Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
Microbes and infection / Institut Pasteur 2004;6(15):1361-7.
2004: Douglas T Golenbock
Introduction: Toll receptors come of age.
Microbes and infection / Institut Pasteur 2004;6(15):1349-50.
2004: Harry Björkbacka; Katherine A Fitzgerald; François Huet; Xiaoman Li; James A Gregory; Melinda A Lee; Christine M Ordija; Nicole E Dowley; Douglas T Golenbock; Mason W Freeman
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
Physiological genomics 2004;19(3):319-30.
2004: Angela Dolganiuc; Shilpa Oak; Karen Kodys; Douglas T Golenbock; Robert W Finberg; Evelyn A Kurt-Jones; Gyongyi Szabo
Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
Gastroenterology 2004;127(5):1513-24.
2004: Ana-Carolina Oliveira; Jaqueline R Peixoto; Luciana Barros de Arruda; Marco A Campos; Ricardo T Gazzinelli; Douglas T Golenbock; Shizuo Akira; José O Previato; Lucia Mendonça-Previato; Alberto Nobrega; Maria Bellio
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5688-96.
2004: Judith Branger; Sandrine Florquin; Sylvia Knapp; Jaklien C Leemans; Jennie M Pater; Peter Speelman; Douglas T Golenbock; Tom van der Poll
LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.
International immunology 2004;16(11):1605-11.
2004: Patricia A Darrah; Maria Chiara G Monaco; Shruti Jain; Mary K Hondalus; Douglas T Golenbock; David Mosser
Innate immune responses to Rhodococcus equi.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1914-24.
2004: Giuseppe Mancuso; Angelina Midiri; Concetta Beninati; Carmelo Biondo; Roberta Galbo; Shizuo Akira; Philipp Henneke; Douglas T Golenbock; Giuseppe Teti
Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6324-9.
2004: Takashi Kaneko; William Goldman; Peter Mellroth; Håkan Steiner; Koichi Fukase; Shoichi Kusumoto; William Harley; Alvin Fox; Douglas T Golenbock; Neal Silverman
Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway.
Immunity 2004;20(5):637-49.
2004: Nicole T Liberati; Katherine A Fitzgerald; Dennis H Kim; Rhonda Feinbaum; Douglas T Golenbock; Frederick M Ausubel
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6593-8.
2004: Harry Björkbacka; Vidya V Kunjathoor; Kathryn J Moore; Stephanie L Koehn; Christine M Ordija; Melinda A Lee; Terry K Means; Kristen Halmen; Andrew D Luster; Douglas T Golenbock; Mason W Freeman
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.
Nature medicine 2004;10(4):416-21.
2004: Tsugumi Okusawa; Mari Fujita; Jun-Ichiro Nakamura; Takeshi Into; Motoaki Yasuda; Atsutoshi Yoshimura; Yoshitaka Hara; Akira Hasebe; Douglas T Golenbock; Manabu Morita; Yoshio Kuroki; Tomohiko Ogawa; Ken-Ichiro Shibata
Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.
Infection and immunity 2004;72(3):1657-65.
2004: Akira Hasebe; Atsutoshi Yoshimura; Takeshi Into; Hideo Kataoka; Saori Tanaka; Shinichi Arakawa; Hiroaki Ishikura; Douglas T Golenbock; Tsutomu Sugaya; Nobuo Tsuchida; Masamitsu Kawanami; Yoshitaka Hara; Ken-Ichiro Shibata
Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease.
Infection and immunity 2004;72(3):1318-25.
2004: Eicke Latz; Jennifer Franko; Douglas T Golenbock; John R Schreiber
Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2431-8.
2004: Eicke Latz; Annett Schoenemeyer; Alberto Visintin; Katherine A Fitzgerald; Brian G Monks; Cathrine F Knetter; Egil Lien; Nadra Nilsen; Terje Espevik; Douglas T Golenbock
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Nature immunology 2004;5(2):190-8.
2004: Sarah M McWhirter; Katherine A Fitzgerald; Jacqueline Rosains; Daniel Rowe; Douglas T Golenbock; Tom Maniatis
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):233-8.
2004: Philipp Henneke; Douglas T Golenbock
Phagocytosis, innate immunity, and host-pathogen specificity.
The Journal of experimental medicine 2004;199(1):1-4.
2004: Robert W Finberg; Fabio Re; Lana Popova; Douglas T Golenbock; Evelyn A Kurt-Jones
Cell activation by Toll-like receptors: role of LBP and CD14.
Journal of endotoxin research 2004;10(6):413-8.
2004: Eicke Latz; Alberto Visintin; Terje Espevik; Douglas T Golenbock
Mechanisms of TLR9 activation.
Journal of endotoxin research 2004;10(6):406-12.
2003: Egil Lien; Douglas T Golenbock
Adjuvants and their signaling pathways: beyond TLRs.
Nature immunology 2003;4(12):1162-4.
2003: Sylvia Knapp; Alex F de Vos; Sandrine Florquin; Douglas T Golenbock; Tom van der Poll
Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice.
Infection and immunity 2003;71(12):6747-53.
2003: Alberto Visintin; Eicke Latz; Brian G Monks; Terje Espevik; Douglas T Golenbock
Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
The Journal of biological chemistry 2003;278(48):48313-20.
2003: Katherine A Fitzgerald; Daniel Rowe; Betsy J Barnes; Daniel R Caffrey; Alberto Visintin; Eicke Latz; Brian G Monks; PAULA PITHA-ROWE; Douglas T Golenbock
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
The Journal of experimental medicine 2003;198(7):1043-55.
2003: Eicke Latz; Douglas T Golenbock
Receptor "cross talk" in innate immunity.
The Journal of clinical investigation 2003;112(8):1136-7.
2003: Keya Sau; Salamatu S Mambula; Eicke Latz; Philipp Henneke; Douglas T Golenbock; Stuart M Levitz
The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.
The Journal of biological chemistry 2003;278(39):37561-8.
2003: Frantisek Sandor; Eicke Latz; Fabio Re; Leisa Mandell; Galina Repik; Douglas T Golenbock; Terje Espevik; Evelyn A Kurt-Jones; Robert W Finberg
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
The Journal of cell biology 2003;162(6):1099-110.
2003: Li-Yun Huang; Julio Aliberti; Cynthia A Leifer; David M Segal; Alan Sher; Douglas T Golenbock; Basil Golding
Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1441-6.
2003: Katherine A Fitzgerald; Sarah M McWhirter; Kerrie L Faia; Daniel Rowe; Eicke Latz; Douglas T Golenbock; Anthony J Coyle; Sha-Mei Liao; Tom Maniatis
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Nature immunology 2003;4(5):491-6.
2003: Teresa Compton; Evelyn A Kurt-Jones; Karl W Boehme; John Belko; Eicke Latz; Douglas T Golenbock; Robert W Finberg
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.
Journal of virology 2003;77(8):4588-96.
2003: Richard Malley; Philipp Henneke; Sarah C Morse; Michael J Cieslewicz; Marc Lipsitch; Claudette M Thompson; Evelyn A Kurt-Jones; James C Paton; Michael R Wessels; Douglas T Golenbock
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1966-71.
2003: Eicke Latz; Alberto Visintin; Egil Lien; Katherine A Fitzgerald; Terje Espevik; Douglas T Golenbock
The LPS receptor generates inflammatory signals from the cell surface.
Journal of endotoxin research 2003;9(6):375-80.
2003: Terje Espevik; Eicke Latz; Egil Lien; Brian G Monks; Douglas T Golenbock
Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs.
Scandinavian journal of infectious diseases 2003;35(9):660-4.
2002: Desiree Van der Kleij; Eicke Latz; Jos F H M Brouwers; Yvonne C M Kruize; Marion Schmitz; Evelyn A Kurt-Jones; Terje Espevik; Esther C de Jong; Martien L Kapsenberg; Douglas T Golenbock; Aloysius Tielens; Maria Yazdanbakhsh
A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.
The Journal of biological chemistry 2002;277(50):48122-9.
2002: Eicke Latz; Alberto Visintin; Egil Lien; Katherine A Fitzgerald; Brian G Monks; Evelyn A Kurt-Jones; Douglas T Golenbock; Terje Espevik
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
The Journal of biological chemistry 2002;277(49):47834-43.
2002: Andrei E Medvedev; Arnd Lentschat; Larry M Wahl; Douglas T Golenbock; Stefanie N Vogel
Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5209-16.
2002: Salamatu S Mambula; Keya Sau; Philipp Henneke; Douglas T Golenbock; Stuart M Levitz
Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.
The Journal of biological chemistry 2002;277(42):39320-6.
2002: Kang K Yang; Brigitte G Dorner; Ulrike Merkel; Bernard Ryffel; Christine Schütt; Douglas T Golenbock; Mason W Freeman; Robert S Jack
Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4475-80.
2002: Philipp Henneke; Osamu Takeuchi; Richard Malley; Egil Lien; Robin R Ingalls; Mason W Freeman; Tanya N Mayadas; Victor Nizet; Shizuo Akira; Dennis L Kasper; Douglas T Golenbock
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3970-7.
2002: Trude H Flo; Liv Ryan; Eicke Latz; Osamu Takeuchi; Brian G Monks; Egil Lien; Øyvind Halaas; Shizuo Akira; Gudmund Skjåk-Braek; Douglas T Golenbock; Terje Espevik
Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
The Journal of biological chemistry 2002;277(38):35489-95.
2002: Joshua Fierer; Mark A Swancutt; Didier Heumann; Douglas T Golenbock
The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6396-403.
2002: loic Guillot; Viviane Balloy; Francis X McCormack; Douglas T Golenbock; Michel Chignard; Mustapha Si-Tahar
Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):5989-92.
2002: Martha Triantafilou; Kensuke Miyake; Douglas T Golenbock; Kathy Triantafilou
Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation.
Journal of cell science 2002;115(Pt 12):2603-11.
2002: Espen Ellingsen; Siegfried Morath; Trude H Flo; Andra Schromm; Thomas Hartung; Christoph Thiemermann; Terje Espevik; Douglas T Golenbock; Daniel Foster; Rigmor Solberg; Ansgar O Aasen; Jacob Wang
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(5):BR149-56.
2002: Philipp Henneke; Douglas T Golenbock
Innate immune recognition of lipopolysaccharide by endothelial cells.
Critical care medicine 2002;30(5 Suppl):S207-13.
2002: Paola Massari; Philipp Henneke; Yu Ho; Eicke Latz; Douglas T Golenbock; Wetzler Lee
Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1533-7.
2002: Atsutoshi Yoshimura; Takashi Kaneko; Yoshifumi Kato; Douglas T Golenbock; Yoshitaka Hara
Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4.
Infection and immunity 2002;70(1):218-25.
2001: Philipp Henneke; Osamu Takeuchi; Jos van Strijp; Hilde-Kari Guttormsen; J A Smith; Andra B Schromm; Terje Espevik; Shizuo Akira; V Nizet; Dennis L Kasper; Douglas T Golenbock
Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7069-76.
2001: Andrei E Medvedev; Philipp Henneke; Andra B Schromm; Egil Lien; Robin R Ingalls; Matthew J Fenton; Douglas T Golenbock; Stefanie N Vogel
Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2257-67.
2001: EH Noss; Rish K Pai; Timothy J Sellati; Justin D Radolf; John Belisle; Douglas T Golenbock; W Henry Boom; Clifford V Harding
Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):910-8.
2001: Andra B Schromm; Egil Lien; Philipp Henneke; J C Chow; A Yoshimura; Holger Heine; Eicke Latz; Brian G Monks; D A Schwartz; K Miyake; Douglas T Golenbock
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
The Journal of experimental medicine 2001;194(1):79-88.
2001: Marco A Campos; Igor Almeida; O Takeuchi; Shizuo Akira; Eneida P Valente; Daniela O Procópio; Luiz Travassos; J A Smith; Douglas T Golenbock; Ricardo T Gazzinelli
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):416-23.
2001: Shy Shoham; Chao Huang; Jian-Min Chen; Douglas T Golenbock; Stuart M Levitz
Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4620-6.
2001: Robin R Ingalls; Egil Lien; Douglas T Golenbock
Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2.
Infection and immunity 2001;69(4):2230-6.
2001: TK Means; Bryan W Jones; Andra B Schromm; B A Shurtleff; J A Smith; Joseph Keane; Douglas T Golenbock; Stefanie N Vogel; Matthew J Fenton
Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):4074-82.
2001: M Bernheiden; J M Heinrich; G Minigo; Christine Schütt; Felix Stelter; M Freeman; Douglas T Golenbock; Robert S Jack
LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.
Journal of endotoxin research 2001;7(6):447-50.
2000: TK Means; Douglas T Golenbock; Matthew J Fenton
Structure and function of Toll-like receptor proteins.
Life sciences 2000;68(3):241-58.
2000: Trude H Flo; Liv Ryan; L Kilaas; G Skjâk-Braek; Robin R Ingalls; Anders Sundan; Douglas T Golenbock; Terje Espevik
Involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers.
Infection and immunity 2000;68(12):6770-6.
2000: Evelyn A Kurt-Jones; L Popova; L Kwinn; Lia M Haynes; Les P Jones; Ralph A Tripp; E E Walsh; Mason W Freeman; Douglas T Golenbock; Larry J Anderson; Robert W Finberg
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.
Nature immunology 2000;1(5):398-401.
2000: Kathryn J Moore; Lorna P Andersson; Robin R Ingalls; Brian G Monks; R Li; M Amin Arnaout; Douglas T Golenbock; Mason W Freeman
Divergent response to LPS and bacteria in CD14-deficient murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4272-80.
2000: TK Means; Douglas T Golenbock; Matthew J Fenton
The biology of Toll-like receptors.
Cytokine & growth factor reviews 2000;11(3):219-32.
2000: Trude H Flo; Oyvind Halaas; Egil Lien; Liv Ryan; Giuseppe Teti; Douglas T Golenbock; Anders Sundan; Terje Espevik
Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):2064-9.
2000: Egil Lien; TK Means; Holger Heine; A Yoshimura; Shoichi Kusumoto; Koichi Fukase; Matthew J Fenton; Masato Oikawa; N Qureshi; Brian G Monks; R W Finberg; Robin R Ingalls; Douglas T Golenbock
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
The Journal of clinical investigation 2000;105(4):497-504.
2000: Robin R Ingalls; Egil Lien; Douglas T Golenbock
Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis.
Journal of endotoxin research 2000;6(5):411-5.
2000: Atsutoshi Yoshimura; H Takada; Takashi Kaneko; I Kato; Douglas T Golenbock; Yoshitaka Hara
Structural requirements of muramylpeptides for induction of Toll-like receptor 2-mediated NF-kappaB activation in CHO cells.
Journal of endotoxin research 2000;6(5):407-10.
1999: TK Means; Egil Lien; A Yoshimura; S Wang; Douglas T Golenbock; Matthew J Fenton
The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6748-55.
1999: Egil Lien; Timothy J Sellati; A Yoshimura; Trude H Flo; G Rawadi; R W Finberg; J David Carroll; Terje Espevik; Robin R Ingalls; Justin D Radolf; Douglas T Golenbock
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
The Journal of biological chemistry 1999;274(47):33419-25.
1999: TK Means; S Wang; Egil Lien; A Yoshimura; Douglas T Golenbock; Matthew J Fenton
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3920-7.
1999: Holger Heine; RL Delude; Brian G Monks; Terje Espevik; Douglas T Golenbock
Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.
The Journal of biological chemistry 1999;274(30):21049-55.
1999: A Yoshimura; Egil Lien; Robin R Ingalls; E Tuomanen; R Dziarski; Douglas T Golenbock
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):1-5.
1999: N Bhat; Pin-Yu Perera; J M Carboni; J Blanco; Douglas T Golenbock; T N Mayadas; Stefanie N Vogel
Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7335-42.
1999: Holger Heine; C J Kirschning; Egil Lien; Brian G Monks; M Rothe; Douglas T Golenbock
Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):6971-5.
1999: Robin R Ingalls; Holger Heine; Egil Lien; A Yoshimura; Douglas T Golenbock
Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.
Infectious disease clinics of North America 1999;13(2):341-53, vii.
1999: Robin R Ingalls; Brian G Monks; Douglas T Golenbock
Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14.
The Journal of biological chemistry 1999;274(20):13993-8.
1998: Robin R Ingalls; Brian G Monks; R Savedra; W J Christ; RL Delude; Andrei E Medvedev; Terje Espevik; Douglas T Golenbock
CD11/CD18 and CD14 share a common lipid A signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5413-20.
1998: Charles M Bliss; Douglas T Golenbock; Sarah Keates; J K Linevsky; Ciarán P Kelly
Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes.
Infection and immunity 1998;66(11):5357-63.
1998: RL Delude; A Yoshimura; Robin R Ingalls; Douglas T Golenbock
Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):3001-9.
1998: Matthew J Fenton; Douglas T Golenbock
LPS-binding proteins and receptors.
Journal of leukocyte biology 1998;64(1):25-32.
1998: Andrei E Medvedev; Trude H Flo; Robin R Ingalls; Douglas T Golenbock; G Teti; Stefanie N Vogel; Terje Espevik
Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4535-42.
1998: Robin R Ingalls; M Amin Arnaout; RL Delude; S Flaherty; R Savedra; Douglas T Golenbock
The CD11/CD18 integrins: characterization of three novel LPS signaling receptors.
Progress in clinical and biological research 1998;397():107-17.
1997: M M Wurfel; Brian G Monks; Robin R Ingalls; R L Dedrick; RL Delude; D Zhou; Norbert Lamping; Ralf R Schumann; Rolf Thieringer; Matthew J Fenton; Samuel D Wright; Douglas T Golenbock
Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.
The Journal of experimental medicine 1997;186(12):2051-6.
1997: S F Flaherty; Douglas T Golenbock; F H Milham; Robin R Ingalls
CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin.
The Journal of surgical research 1997;73(1):85-9.
1997: Matthew Pollack; CA Ohl; Douglas T Golenbock; F Di Padova; L M Wahl; Nancy L Koles; G Guelde; B G Monks
Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3519-30.
1997: Robin R Ingalls; M Amin Arnaout; Douglas T Golenbock
Outside-in signaling by lipopolysaccharide through a tailless integrin.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):433-8.
1997: Stuart M Levitz; A Tabuni; Thomas R Kozel; Randall S MacGill; R R Ingalls; Douglas T Golenbock
Binding of Cryptococcus neoformans to heterologously expressed human complement receptors.
Infection and immunity 1997;65(3):931-5.
1997: TA Lodie; R Savedra; Douglas T Golenbock; C P Van Beveren; R A Maki; Matthew J Fenton
Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1848-56.
1996: R Savedra; RL Delude; Robin R Ingalls; Matthew J Fenton; Douglas T Golenbock
Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2549-54.
1996: Stuart M Levitz; A Tabuni; Shuhua Nong; Douglas T Golenbock
Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.
Infection and immunity 1996;64(3):945-51.
1995: RL Delude; R Savedra; H Zhao; Rolf Thieringer; S Yamamoto; Matthew J Fenton; Douglas T Golenbock
CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9288-92.
1995: Robin R Ingalls; Peter A Rice; N Qureshi; K Takayama; J S Lin; Douglas T Golenbock
The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated.
Infection and immunity 1995;63(8):3125-30.
1995: Robin R Ingalls; Douglas T Golenbock
CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.
The Journal of experimental medicine 1995;181(4):1473-9.
1995: RL Delude; R Savedra; S Yamamoto; Douglas T Golenbock
Use of CD14 transfected cells to study LPS-antagonist action.
Progress in clinical and biological research 1995;392():487-97.
1994: RL Delude; Matthew J Fenton; R Savedra; Pin-Yu Perera; Stefanie N Vogel; Rolf Thieringer; Douglas T Golenbock
CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
The Journal of biological chemistry 1994;269(35):22253-60.
1994: Stuart M Levitz; A Tabuni; Hardy Kornfeld; C C Reardon; Douglas T Golenbock
Production of tumor necrosis factor alpha in human leukocytes stimulated by Cryptococcus neoformans.
Infection and immunity 1994;62(5):1975-81.
1993: Douglas T Golenbock; Y Liu; F H Millham; M W Freeman; R A Zoeller
Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.
The Journal of biological chemistry 1993;268(29):22055-9.
1991: Douglas T Golenbock; R Y Hampton; N Qureshi; K Takayama; C R Raetz
Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.
The Journal of biological chemistry 1991;266(29):19490-8.
1991: R Y Hampton; Douglas T Golenbock; M Penman; M Krieger; C R Raetz
Recognition and plasma clearance of endotoxin by scavenger receptors.
Nature 1991;352(6333):342-4.
1990: Douglas T Golenbock; R Y Hampton; C R Raetz; Samuel D Wright
Human phagocytes have multiple lipid A-binding sites.
Infection and immunity 1990;58(12):4069-75.
1988: R Y Hampton; Douglas T Golenbock; C R Raetz
Lipid A binding sites in membranes of macrophage tumor cells.
The Journal of biological chemistry 1988;263(29):14802-7.
1988: Douglas T Golenbock; J E Leggett; P Rasmussen; William A Craig; C R Raetz; R A Proctor
Lipid X protects mice against fatal Escherichia coli infection.
Infection and immunity 1988;56(4):779-84.
1988: Douglas T Golenbock; S Ebert; J A Will; R A Proctor
Elimination and tissue distribution of the monosaccharide lipid A precursor, lipid X, in mice and sheep.
Antimicrobial agents and chemotherapy 1988;32(1):37-41.
1988: C R Raetz; K A Brozek; T Clementz; J D Coleman; S M Galloway; Douglas T Golenbock; R Y Hampton
Gram-negative endotoxin: a biologically active lipid.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():973-82.
1987: Douglas T Golenbock; J A Will; C R Raetz; R A Proctor
Lipid X ameliorates pulmonary hypertension and protects sheep from death due to endotoxin.
Infection and immunity 1987;55(10):2471-6.