Douglas Golenbock

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Kenny Elaine F; Talbot Suzanne; Gong Mei; Golenbock Douglas T; Bryant Clare E; O'Neill Luke A J
MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Verstak Brett; Nagpal Kamalpreet; Bottomley Stephen P; Golenbock Douglas T; Hertzog Paul J; Mansell Ashley
MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
Nagpal Kamalpreet; Plantinga Theo S; Wong Joyce; Monks Brian G; Gay Nicholas J; Netea Mihai G; Fitzgerald Katherine A; Golenbock Douglas T
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.

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All Publications

2009: Kenny Elaine F; Talbot Suzanne; Gong Mei; Golenbock Douglas T; Bryant Clare E; O'Neill Luke A J
MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3642-51.
2009: Verstak Brett; Nagpal Kamalpreet; Bottomley Stephen P; Golenbock Douglas T; Hertzog Paul J; Mansell Ashley
MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
The Journal of biological chemistry 2009;284(36):24192-203.
2009: Nagpal Kamalpreet; Plantinga Theo S; Wong Joyce; Monks Brian G; Gay Nicholas J; Netea Mihai G; Fitzgerald Katherine A; Golenbock Douglas T
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
The Journal of biological chemistry 2009;284(38):25742-8.
2009: Santos-Sierra Sandra; Deshmukh Sachin D; Kalnitski Julia; Küenzi Peter; Wymann Matthias P; Golenbock Douglas T; Henneke Philipp
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
The EMBO journal 2009;28(14):2018-27.
2009: Palsson-McDermott Eva M; Doyle Sarah L; McGettrick Anne F; Hardy Matthew; Husebye Harald; Banahan Kathy; Gong Mei; Golenbock Douglas; Espevik Terje; O'Neill Luke A J
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
Nature immunology 2009;10(6):579-86.
2009: Kenzel Sybille; Santos-Sierra Sandra; Deshmukh Sachin D; Moeller Inga; Ergin Bilge; Fitzgerald Katherine A; Lien Egil; Akira Shizuo; Golenbock Douglas T; Henneke Philipp
Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
Infection and immunity 2009;77(6):2474-81.
2009: He Yuxian; Barker Sophie J; MacDonald Angus J; Yu Yu; Cao Long; Li Jingjing; Parhar Ranjit; Heck Susanne; Hartmann Susanne; Golenbock Douglas T; Jiang Shibo; Libri Nathan A; Semper Amanda E; Rosenberg William M; Lustigman Sara
Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4005-16.
2009: Franklin Bernardo S; Parroche Peggy; Ataíde Marco Antonio; Lauw Fanny; Ropert Catherine; de Oliveira Rosane B; Pereira Dhelio; Tada Mauro Shugiro; Nogueira Paulo; da Silva Luiz Hildebrando Pereira; Bjorkbacka Harry; Golenbock Douglas T; Gazzinelli Ricardo T
Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5789-94.
2009: Sandanger Øystein; Ryan Liv; Bohnhorst Janne; Iversen Ann-Charlotte; Husebye Harald; Halaas Øyvind; Landrø Linn; Aukrust Pål; Frøland Stig S; Elson Greg; Visintin Alberto; Øktedalen Olav; Damås Jan Kristian; Sundan Anders; Golenbock Douglas; Espevik Terje
IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):588-95.
2009: Drage Michael G; Pecora Nicole D; Hise Amy G; Febbraio Maria; Silverstein Roy L; Golenbock Douglas T; Boom W Henry; Harding Clifford V
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Cellular immunology 2009;258(1):29-37.
2008: Charrel-Dennis Marie; Latz Eicke; Halmen Kristen A; Trieu-Cuot Patrick; Fitzgerald Katherine A; Kasper Dennis L; Golenbock Douglas T
TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
Cell host & microbe 2008;4(6):543-54.
2008: Halle Annett; Hornung Veit; Petzold Gabor C; Stewart Cameron R; Monks Brian G; Reinheckel Thomas; Fitzgerald Katherine A; Latz Eicke; Moore Kathryn J; Golenbock Douglas T
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Nature immunology 2008;9(8):857-65.
2008: Bartholomeu Daniella C; Ropert Catherine; Melo Mariane B; Parroche Peggy; Junqueira Caroline F; Teixeira Santuza M R; Sirois Cherilyn; Kasperkovitz Pia; Knetter Cathrine F; Lien Egil; Latz Eicke; Golenbock Douglas T; Gazzinelli Ricardo T
Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1333-44.
2008: Yoshioka Hidenobu; Yoshimura Atsutoshi; Kaneko Takashi; Golenbock Douglas T; Hara Yoshitaka
Analysis of the activity to induce toll-like receptor (TLR)2- and TLR4-mediated stimulation of supragingival plaque.
Journal of periodontology 2008;79(5):920-8.
2008: Henneke Philipp; Dramsi Shaynoor; Mancuso Giuseppe; Chraibi Kamila; Pellegrini Elisabeth; Theilacker Christian; Hübner Johannes; Santos-Sierra Sandra; Teti Giuseppe; Golenbock Douglas T; Poyart Claire; Trieu-Cuot Patrick
Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6149-58.
2008: Jain Vishal; Halle Annett; Halmen Kristen A; Lien Egil; Charrel-Dennis Marie; Ram Sanjay; Golenbock Douglas T; Visintin Alberto
Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling.
Blood 2008;111(9):4637-45.
2008: Knapp Sylvia; von Aulock Sonja; Leendertse Masja; Haslinger Isabella; Draing Christian; Golenbock Douglas T; van der Poll Tom
Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3478-84.
2008: Ueno Keiko; Koga Takeshi; Kato Kosuke; Golenbock Douglas T; Gendler Sandra J; Kai Hirofumi; Kim K Chul
MUC1 mucin is a negative regulator of toll-like receptor signaling.
American journal of respiratory cell and molecular biology 2008;38(3):263-8.
2008: Zhou Shenghua; Halle Annett; Kurt-Jones Evelyn A; Cerny Anna M; Porpiglia Ermelinda; Rogers Michael; Golenbock Douglas T; Finberg Robert W
Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.
Journal of neuroimmunology 2008;194(1-2):70-82.
2008: Asagiri Masataka; Hirai Toshitake; Kunigami Toshihiro; Kamano Shunya; Gober Hans-Jürgen; Okamoto Kazuo; Nishikawa Keizo; Latz Eicke; Golenbock Douglas T; Aoki Kazuhiro; Ohya Keiichi; Imai Yuuki; Morishita Yasuyuki; Miyazono Kohei; Kato Shigeaki; Saftig Paul; Takayanagi Hiroshi
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Science (New York, N.Y.) 2008;319(5863):624-7.
2008: Meng Jianmin; Parroche Peggy; Golenbock Douglas T; McKnight C James
The differential impact of disulfide bonds and N-linked glycosylation on the stability and function of CD14.
The Journal of biological chemistry 2008;283(6):3376-84.
2007: Nordone Sushila K; Ignacio Glicerio A; Su Lishan; Sempowski Gregory D; Golenbock Douglas T; Li Liwu; Dean Gregg A
Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation.
AIDS research and human retroviruses 2007;23(11):1387-95.
2007: Sweet Charles R; Conlon Joseph; Golenbock Douglas T; Goguen Jon; Silverman Neal
YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction.
Cellular microbiology 2007;9(11):2700-15.
2007: Debierre-Grockiego Françoise; Campos Marco A; Azzouz Nahid; Schmidt Jörg; Bieker Ulrike; Resende Marianne Garcia; Mansur Daniel Santos; Weingart Ralf; Schmidt Richard R; Golenbock Douglas T; Gazzinelli Ricardo T; Schwarz Ralph T
Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1129-37.
2007: McCall Matthew B B; Netea Mihai G; Hermsen Cornelus C; Jansen Trees; Jacobs Liesbeth; Golenbock Douglas; van der Ven André J A M; Sauerwein Robert W
Plasmodium falciparum infection causes proinflammatory priming of human TLR responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):162-71.
2007: Chen Chun-Jen; Kono Hajime; Golenbock Douglas; Reed George; Akira Shizuo; Rock Kenneth L
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
Nature medicine 2007;13(7):851-6.
2007: Latz Eicke; Verma Anjali; Visintin Alberto; Gong Mei; Sirois Cherilyn M; Klein Dionne C G; Monks Brian G; McKnight C James; Lamphier Marc S; Duprex W Paul; Espevik Terje; Golenbock Douglas T
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Nature immunology 2007;8(7):772-9.
2007: Fitzgerald Katherine A; Golenbock Douglas T
Immunology. The shape of things to come.
Science (New York, N.Y.) 2007;316(5831):1574-6.
2007: Franklin Bernardo S; Rodrigues Soraia O; Antonelli Lis R; Oliveira Roberta V; Goncalves Arthur M; Sales-Junior Policarpo A; Valente Eneida P; Alvarez-Leite Jacqueline I; Ropert Catherine; Golenbock Douglas T; Gazzinelli Ricardo T
MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria.
Microbes and infection / Institut Pasteur 2007;9(7):881-90.
2007: Taylor Kristen R; Yamasaki Kenshi; Radek Katherine A; Di Nardo Anna; Goodarzi Heidi; Golenbock Douglas; Beutler Bruce; Gallo Richard L
Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.
The Journal of biological chemistry 2007;282(25):18265-75.
2007: Tian Jane; Avalos Ana Maria; Mao Su-Yau; Chen Bo; Senthil Kannaki; Wu Herren; Parroche Peggy; Drabic Stacey; Golenbock Douglas; Sirois Cherilyn; Hua Jing; An Ling Ling; Audoly Laurent; La Rosa Greg; Bierhaus Angelika; Naworth Peter; Marshak-Rothstein Ann; Crow Mary K; Fitzgerald Katherine A; Latz Eicke; Kiener Peter A; Coyle Anthony J
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Nature immunology 2007;8(5):487-96.
2007: Miggin Sinead M; Pålsson-McDermott Eva; Dunne Aisling; Jefferies Caroline; Pinteaux Emmanuel; Banahan Kathy; Murphy Caroline; Moynagh Paul; Yamamoto Masahiro; Akira Shizuo; Rothwell Nancy; Golenbock Douglas; Fitzgerald Katherine A; O'Neill Luke A J
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3372-7.
2007: Parroche Peggy; Lauw Fanny N; Goutagny Nadege; Latz Eicke; Monks Brian G; Visintin Alberto; Halmen Kristen A; Lamphier Marc; Olivier Martin; Bartholomeu Daniella C; Gazzinelli Ricardo T; Golenbock Douglas T
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1919-24.
2007: Hise Amy G; Daehnel Katrin; Gillette-Ferguson Illona; Cho Eun; McGarry Helen F; Taylor Mark J; Golenbock Douglas T; Fitzgerald Katherine A; Kazura James W; Pearlman Eric
Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):1068-76.
2006: Wang Qun; McLoughlin Rachel M; Cobb Brian A; Charrel-Dennis Marie; Zaleski Kathleen J; Golenbock Douglas; Tzianabos Arthur O; Kasper Dennis L
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.
The Journal of experimental medicine 2006;203(13):2853-63.
2006: Seimon Tracie A; Obstfeld Amrom; Moore Kathryn J; Golenbock Douglas T; Tabas Ira
Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19794-9.
2006: Visintin Alberto; Halmen Kristen A; Khan Naseema; Monks Brian G; Golenbock Douglas T; Lien Egil
MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).
Journal of leukocyte biology 2006;80(6):1584-92.
2006: Wang Jennifer P; Liu Ping; Latz Eicke; Golenbock Douglas T; Finberg Robert W; Libraty Daniel H
Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7114-21.
2006: Lamphier Marc S; Sirois Cherilyn M; Verma Anjali; Golenbock Douglas T; Latz Eicke
TLR9 and the recognition of self and non-self nucleic acids.
Annals of the New York Academy of Sciences 2006;1082():31-43.
2006: Chen Chun-Jen; Shi Yan; Hearn Arron; Fitzgerald Kate; Golenbock Douglas; Reed George; Akira Shizuo; Rock Kenneth L
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
The Journal of clinical investigation 2006;116(8):2262-71.
2006: Yu Man; Wang Haichao; Ding Aihao; Golenbock Douglas T; Latz Eicke; Czura Christopher J; Fenton Matthew J; Tracey Kevin J; Yang Huan
HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
Shock (Augusta, Ga.) 2006;26(2):174-9.
2006: Lehnardt Seija; Henneke Philipp; Lien Egil; Kasper Dennis L; Volpe Joseph J; Bechmann Ingo; Nitsch Robert; Weber Joerg R; Golenbock Douglas T; Vartanian Timothy
A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):583-92.
2006: McGettrick Anne F; Brint Elizabeth K; Palsson-McDermott Eva M; Rowe Daniel C; Golenbock Douglas T; Gay Nicholas J; Fitzgerald Katherine A; O'Neill Luke A J
Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9196-201.
2006: Rowe Daniel C; McGettrick Anne F; Latz Eicke; Monks Brian G; Gay Nicholas J; Yamamoto Masahiro; Akira Shizuo; O'Neill Luke A; Fitzgerald Katherine A; Golenbock Douglas T
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6299-304.
2006: Cario Elke; Golenbock Douglas T; Visintin Alberto; Rünzi Michael; Gerken Guido; Podolsky Daniel K
Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4258-66.
2006: Knapp Sylvia; Florquin Sandrine; Golenbock Douglas T; van der Poll Tom
Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3189-95.
2006: Kenzel Sybille; Mancuso Guiseppe; Malley Richard; Teti Guiseppe; Golenbock Douglas T; Henneke Philipp
c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3181-8.
2006: Massari Paola; Visintin Alberto; Gunawardana Jay; Halmen Kristen A; King Carol A; Golenbock Douglas T; Wetzler Lee M
Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2373-80.
2006: Rogers K A; Rogers A B; Leav B A; Sanchez A; Vannier E; Uematsu S; Akira S; Golenbock D; Ward H D
MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice.
Infection and immunity 2006;74(1):549-56.
2006: Santos-Sierra Sandra; Golenbock Douglas T; Henneke Philipp
Toll-like receptor-dependent discrimination of streptococci.
Journal of endotoxin research 2006;12(5):307-12.
2006: Visintin Alberto; Iliev Dimitar B; Monks Brian G; Halmen Kristen A; Golenbock Douglas T
MD-2.
Immunobiology 2006;211(6-8):437-47.
2006: Kishimoto Mami; Yoshimura Atsutoshi; Naito Mariko; Okamoto Kuniaki; Yamamoto Kenji; Golenbock Douglas T; Hara Yoshitaka; Nakayama Koji
Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling.
Microbiology and immunology 2006;50(4):315-25.
2005: Mann Paul B; Wolfe Daniel; Latz Eicke; Golenbock Douglas; Preston Andrew; Harvill Eric T
Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection.
Infection and immunity 2005;73(12):8144-52.
2005: Romics Laszlo; Dolganiuc Angela; Velayudham Arumugam; Kodys Karen; Mandrekar Pranoti; Golenbock Douglas; Kurt-Jones Evelyn; Szabo Gyongyi
Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
Journal of leukocyte biology 2005;78(6):1255-64.
2005: Visintin Alberto; Halmen Kristen A; Latz Eicke; Monks Brian G; Golenbock Douglas T
Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6465-72.
2005: Yang Xin; Coriolan Daniel; Schultz Kelly; Golenbock Douglas T; Beasley Debbie
Toll-like receptor 2 mediates persistent chemokine release by Chlamydia pneumoniae-infected vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(11):2308-14.
2005: Srivastava Amit; Henneke Philipp; Visintin Alberto; Morse Sarah C; Martin Victoria; Watkins Claire; Paton James C; Wessels Michael R; Golenbock Douglas T; Malley Richard
The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.
Infection and immunity 2005;73(10):6479-87.
2005: Lauw Fanny N; Caffrey Daniel R; Golenbock Douglas T
Of mice and man: TLR11 (finally) finds profilin.
Trends in immunology 2005;26(10):509-11.
2005: Yang Xin; Coriolan Daniel; Murthy Vanishree; Schultz Kelly; Golenbock Douglas T; Beasley Debbie
Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.
American journal of physiology. Heart and circulatory physiology 2005;289(3):H1069-76.
2005: Triantafilou Kathy; Orthopoulos George; Vakakis Emmanouil; Ahmed Mohamed Abd Elrahman; Golenbock Douglas T; Lepper Philipp M; Triantafilou Martha
Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent.
Cellular microbiology 2005;7(8):1117-26.
2005: Boon Hinckley Middleton; Reynolds C Michael; Ribeiro Anthony A; McGrath Sara C; Cotter Robert J; Lauw Fanny N; Golenbock Douglas T; Raetz Christian R H
A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A.
The Journal of biological chemistry 2005;280(34):30214-24.
2005: Branger Judith; Leemans Jaklien C; Florquin Sandrine; Speelman Peter; Golenbock Douglas T; van der Poll Tom
Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection.
Clinical immunology (Orlando, Fla.) 2005;116(2):174-81.
2005: Divanovic Senad; Trompette Aurelien; Atabani Sowsan F; Madan Rajat; Golenbock Douglas T; Visintin Alberto; Finberg Robert W; Tarakhovsky Alexander; Vogel Stefanie N; Belkaid Yasmine; Kurt-Jones Evelyn A; Karp Christopher L
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Nature immunology 2005;6(6):571-8.
2005: Henneke Philipp; Morath Siegfried; Uematsu Satoshi; Weichert Stefan; Pfitzenmaier Markus; Takeuchi Osamu; Müller Andrea; Poyart Claire; Akira Shizuo; Berner Reinhard; Teti Giuseppe; Geyer Armin; Hartung Thomas; Trieu-Cuot Patrick; Kasper Dennis L; Golenbock Douglas T
Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6449-55.
2005: Schoenemeyer Annett; Barnes Betsy J; Mancl Margo E; Latz Eicke; Goutagny Nadege; Pitha Paula M; Fitzgerald Katherine A; Golenbock Douglas T
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
The Journal of biological chemistry 2005;280(17):17005-12.
2005: Zhou Shenghua; Kurt-Jones Evelyn A; Mandell Leisa; Cerny Anna; Chan Melvin; Golenbock Douglas T; Finberg Robert W
MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection.
European journal of immunology 2005;35(3):822-30.
2005: Johnson Angela C; Heinzel Fred P; Diaconu Eugenia; Sun Yan; Hise Amy G; Golenbock Douglas; Lass Jonathan H; Pearlman Eric
Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation.
Investigative ophthalmology & visual science 2005;46(2):589-95.
2005: Means Terry K; Latz Eicke; Hayashi Fumitaka; Murali Mandakolathur R; Golenbock Douglas T; Luster Andrew D
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
The Journal of clinical investigation 2005;115(2):407-17.
2005: Kaneko Takashi; Golenbock Douglas; Silverman Neal
Peptidoglycan recognition by the Drosophila Imd pathway.
Journal of endotoxin research 2005;11(6):383-9.
2005: Divanovic Senad; Trompette Aurelien; Atabani Sowsan F; Madan Rajat; Golenbock Douglas T; Visintin Alberto; Finberg Robert W; Tarakhovsky Alexander; Vogel Stefanie N; Belkaid Yasmine; Kurt-Jones Evelyn A; Karp Christopher L
Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.
Journal of endotoxin research 2005;11(6):363-8.
2004: Fitzgerald Katherine A; Rowe Daniel C; Golenbock Douglas T
Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
Microbes and infection / Institut Pasteur 2004;6(15):1361-7.
2004: Golenbock Douglas T
Introduction: Toll receptors come of age.
Microbes and infection / Institut Pasteur 2004;6(15):1349-50.
2004: Zamboni Dario S; Campos Marco A; Torrecilhas Ana C T; Kiss Kati; Samuel James E; Golenbock Douglas T; Lauw Fanny N; Roy Craig R; Almeida Igor C; Gazzinelli Ricardo T
Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
The Journal of biological chemistry 2004;279(52):54405-15.
2004: Wieland Catharina W; Knapp Sylvia; Florquin Sandrine; de Vos Alex F; Takeda Kiyoshi; Akira Shizuo; Golenbock Douglas T; Verbon Annelies; van der Poll Tom
Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
American journal of respiratory and critical care medicine 2004;170(12):1367-74.
2004: Dolganiuc Angela; Oak Shilpa; Kodys Karen; Golenbock Douglas T; Finberg Robert W; Kurt-Jones Evelyn; Szabo Gyongyi
Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
Gastroenterology 2004;127(5):1513-24.
2004: Oliveira Ana-Carolina; Peixoto Jaqueline R; de Arruda Luciana B; Campos Marco A; Gazzinelli Ricardo T; Golenbock Douglas T; Akira Shizuo; Previato José O; Mendonça-Previato Lúcia; Nobrega Alberto; Bellio Maria
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5688-96.
2004: Branger Judith; Florquin Sandrine; Knapp Sylvia; Leemans Jaklien C; Pater Jennie M; Speelman Peter; Golenbock Douglas T; van der Poll Tom
LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.
International immunology 2004;16(11):1605-11.
2004: Björkbacka Harry; Fitzgerald Katherine A; Huet François; Li Xiaoman; Gregory James A; Lee Melinda A; Ordija Christine M; Dowley Nicole E; Golenbock Douglas T; Freeman Mason W
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
Physiological genomics 2004;19(3):319-30.
2004: Darrah Patricia A; Monaco Maria Chiara G; Jain Shruti; Hondalus Mary K; Golenbock Douglas T; Mosser David M
Innate immune responses to Rhodococcus equi.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1914-24.
2004: Kaneko Takashi; Goldman William E; Mellroth Peter; Steiner Håkan; Fukase Koichi; Kusumoto Shoichi; Harley William; Fox Alvin; Golenbock Douglas; Silverman Neal
Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway.
Immunity 2004;20(5):637-49.
2004: Mancuso Giuseppe; Midiri Angelina; Beninati Concetta; Biondo Carmelo; Galbo Roberta; Akira Shizuo; Henneke Philipp; Golenbock Douglas; Teti Giuseppe
Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6324-9.
2004: Liberati Nicole T; Fitzgerald Katherine A; Kim Dennis H; Feinbaum Rhonda; Golenbock Douglas T; Ausubel Frederick M
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6593-8.
2004: Björkbacka Harry; Kunjathoor Vidya V; Moore Kathryn J; Koehn Stephanie; Ordija Christine M; Lee Melinda A; Means Terry; Halmen Kristen; Luster Andrew D; Golenbock Douglas T; Freeman Mason W
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.
Nature medicine 2004;10(4):416-21.
2004: Okusawa Tsugumi; Fujita Mari; Nakamura Jun-Ichiro; Into Takeshi; Yasuda Motoaki; Yoshimura Atsutoshi; Hara Yoshitaka; Hasebe Akira; Golenbock Douglas T; Morita Manabu; Kuroki Yoshio; Ogawa Tomohiko; Shibata Ken-Ichiro
Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.
Infection and immunity 2004;72(3):1657-65.
2004: Hasebe Akira; Yoshimura Atsutoshi; Into Takeshi; Kataoka Hideo; Tanaka Saori; Arakawa Shinichi; Ishikura Hiroaki; Golenbock Douglas T; Sugaya Tsutomu; Tsuchida Nobuo; Kawanami Masamitsu; Hara Yoshitaka; Shibata Ken-Ichiro
Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease.
Infection and immunity 2004;72(3):1318-25.
2004: Latz Eicke; Franko Jennifer; Golenbock Douglas T; Schreiber John R
Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2431-8.
2004: Latz Eicke; Schoenemeyer Annett; Visintin Alberto; Fitzgerald Katherine A; Monks Brian G; Knetter Cathrine F; Lien Egil; Nilsen Nadra J; Espevik Terje; Golenbock Douglas T
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Nature immunology 2004;5(2):190-8.
2004: Henneke Phillip; Golenbock Douglas T
Phagocytosis, innate immunity, and host-pathogen specificity.
The Journal of experimental medicine 2004;199(1):1-4.
2004: McWhirter Sarah M; Fitzgerald Katherine A; Rosains Jacqueline; Rowe Daniel C; Golenbock Douglas T; Maniatis Tom
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):233-8.
2004: Finberg Robert W; Re Fabio; Popova Lana; Golenbock Douglas T; Kurt-Jones Evelyn A
Cell activation by Toll-like receptors: role of LBP and CD14.
Journal of endotoxin research 2004;10(6):413-8.
2004: Latz Eicke; Visintin Alberto; Espevik Terje; Golenbock Douglas T
Mechanisms of TLR9 activation.
Journal of endotoxin research 2004;10(6):406-12.
2003: Lien Egil; Golenbock Douglas T
Adjuvants and their signaling pathways: beyond TLRs.
Nature immunology 2003;4(12):1162-4.
2003: Knapp Sylvia; de Vos Alex F; Florquin Sandrine; Golenbock Douglas T; van der Poll Tom
Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice.
Infection and immunity 2003;71(12):6747-53.
2003: Visintin Alberto; Latz Eicke; Monks Brian G; Espevik Terje; Golenbock Douglas T
Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
The Journal of biological chemistry 2003;278(48):48313-20.
2003: Latz Eicke; Golenbock Douglas T
Receptor "cross talk" in innate immunity.
The Journal of clinical investigation 2003;112(8):1136-7.
2003: Fitzgerald Katherine A; Rowe Daniel C; Barnes Betsy J; Caffrey Daniel R; Visintin Alberto; Latz Eicke; Monks Brian; Pitha Paula M; Golenbock Douglas T
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
The Journal of experimental medicine 2003;198(7):1043-55.
2003: Sandor Frantisek; Latz Eicke; Re Fabio; Mandell Leisa; Repik Galina; Golenbock Douglas T; Espevik Terje; Kurt-Jones Evelyn A; Finberg Robert W
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
The Journal of cell biology 2003;162(6):1099-110.
2003: Sau Keya; Mambula Salamatu S; Latz Eicke; Henneke Philipp; Golenbock Douglas T; Levitz Stuart M
The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.
The Journal of biological chemistry 2003;278(39):37561-8.
2003: Huang Li-Yun; Aliberti Julio; Leifer Cynthia A; Segal David M; Sher Alan; Golenbock Douglas T; Golding Basil
Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1441-6.
2003: Fitzgerald Katherine A; McWhirter Sarah M; Faia Kerrie L; Rowe Daniel C; Latz Eicke; Golenbock Douglas T; Coyle Anthony J; Liao Sha-Mei; Maniatis Tom
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Nature immunology 2003;4(5):491-6.
2003: Compton Teresa; Kurt-Jones Evelyn A; Boehme Karl W; Belko John; Latz Eicke; Golenbock Douglas T; Finberg Robert W
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.
Journal of virology 2003;77(8):4588-96.
2003: Malley Richard; Henneke Philipp; Morse Sarah C; Cieslewicz Michael J; Lipsitch Marc; Thompson Claudette M; Kurt-Jones Evelyn; Paton James C; Wessels Michael R; Golenbock Douglas T
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1966-71.
2003: Latz Eicke; Visintin Alberto; Lien Egil; Fitzgerald Kate A; Espevik Terje; Golenbock Douglas T
The LPS receptor generates inflammatory signals from the cell surface.
Journal of endotoxin research 2003;9(6):375-80.
2003: Espevik Terje; Latz Eicke; Lien Egil; Monks Brian; Golenbock Douglas T
Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs.
Scandinavian journal of infectious diseases 2003;35(9):660-4.
2002: van der Kleij Desiree; Latz Eicke; Brouwers Jos F H M; Kruize Yvonne C M; Schmitz Marion; Kurt-Jones Evelyn A; Espevik Terje; de Jong Esther C; Kapsenberg Martien L; Golenbock Douglas T; Tielens Aloysius G M; Yazdanbakhsh Maria
A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.
The Journal of biological chemistry 2002;277(50):48122-9.
2002: Latz Eicke; Visintin Alberto; Lien Egil; Fitzgerald Kate A; Monks Brian G; Kurt-Jones Evelyn A; Golenbock Douglas T; Espevik Terje
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
The Journal of biological chemistry 2002;277(49):47834-43.
2002: Medvedev Andrei E; Lentschat Arnd; Wahl Larry M; Golenbock Douglas T; Vogel Stefanie N
Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5209-16.
2002: Yang Kang K; Dorner Brigitte G; Merkel Ulrike; Ryffel Bernard; Schütt Christine; Golenbock Douglas; Freeman Mason W; Jack Robert S
Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4475-80.
2002: Henneke Philipp; Takeuchi Osamu; Malley Richard; Lien Egil; Ingalls Robin R; Freeman Mason W; Mayadas Tanya; Nizet Victor; Akira Shizuo; Kasper Dennis L; Golenbock Douglas T
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3970-7.
2002: Mambula Salamatu S; Sau Keya; Henneke Philipp; Golenbock Douglas T; Levitz Stuart M
Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.
The Journal of biological chemistry 2002;277(42):39320-6.
2002: Flo Trude H; Ryan Liv; Latz Eicke; Takeuchi Osamu; Monks Brian G; Lien Egil; Halaas Øyvind; Akira Shizuo; Skjåk-Braek Gudmund; Golenbock Douglas T; Espevik Terje
Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
The Journal of biological chemistry 2002;277(38):35489-95.
2002: Fierer Joshua; Swancutt Mark A; Heumann Didier; Golenbock Douglas
The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6396-403.
2002: Guillot Loïc; Balloy Viviane; McCormack Francis X; Golenbock Douglas T; Chignard Michel; Si-Tahar Mustapha
Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):5989-92.
2002: Triantafilou Martha; Miyake Kensuke; Golenbock Douglas T; Triantafilou Kathy
Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation.
Journal of cell science 2002;115(Pt 12):2603-11.
2002: Ellingsen Espen; Morath Siegfried; Flo Trude; Schromm Andra; Hartung Thomas; Thiemermann Christoph; Espevik Terje; Golenbock Douglas; Foster Daniel; Solberg Rigmor; Aasen Ansgar; Wang Jacob
Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
Medical science monitor : international medical journal of experimental and clinical research 2002;8(5):BR149-56.
2002: Henneke Philipp; Golenbock Douglas T
Innate immune recognition of lipopolysaccharide by endothelial cells.
Critical care medicine 2002;30(5 Suppl):S207-13.
2002: Massari Paola; Henneke Philipp; Ho Yu; Latz Eicke; Golenbock Douglas T; Wetzler Lee M
Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1533-7.
2002: Yoshimura Atsutoshi; Kaneko Takashi; Kato Yoshifumi; Golenbock Douglas T; Hara Yoshitaka
Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4.
Infection and immunity 2002;70(1):218-25.
2001: Henneke P; Takeuchi O; van Strijp J A; Guttormsen H K; Smith J A; Schromm A B; Espevik T A; Akira S; Nizet V; Kasper D L; Golenbock D T
Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7069-76.
2001: Medvedev A E; Henneke P; Schromm A; Lien E; Ingalls R; Fenton M J; Golenbock D T; Vogel S N
Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2257-67.
2001: Noss E H; Pai R K; Sellati T J; Radolf J D; Belisle J; Golenbock D T; Boom W H; Harding C V
Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):910-8.
2001: Schromm A B; Lien E; Henneke P; Chow J C; Yoshimura A; Heine H; Latz E; Monks B G; Schwartz D A; Miyake K; Golenbock D T
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
The Journal of experimental medicine 2001;194(1):79-88.
2001: Campos M A; Almeida I C; Takeuchi O; Akira S; Valente E P; Procópio D O; Travassos L R; Smith J A; Golenbock D T; Gazzinelli R T
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):416-23.
2001: Shoham S; Huang C; Chen J M; Golenbock D T; Levitz S M
Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4620-6.
2001: Ingalls R R; Lien E; Golenbock D T
Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2.
Infection and immunity 2001;69(4):2230-6.
2001: Means T K; Jones B W; Schromm A B; Shurtleff B A; Smith J A; Keane J; Golenbock D T; Vogel S N; Fenton M J
Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):4074-82.
2001: Bernheiden M; Heinrich J M; Minigo G; Schütt C; Stelter F; Freeman M; Golenbock D; Jack R S
LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.
Journal of endotoxin research 2001;7(6):447-50.
2000: Means T K; Golenbock D T; Fenton M J
Structure and function of Toll-like receptor proteins.
Life sciences 2000;68(3):241-58.
2000: Flo T H; Ryan L; Kilaas L; Skjâk-Braek G; Ingalls R R; Sundan A; Golenbock D T; Espevik T
Involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers.
Infection and immunity 2000;68(12):6770-6.
2000: Kurt-Jones E A; Popova L; Kwinn L; Haynes L M; Jones L P; Tripp R A; Walsh E E; Freeman M W; Golenbock D T; Anderson L J; Finberg R W
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.
Nature immunology 2000;1(5):398-401.
2000: Moore K J; Andersson L P; Ingalls R R; Monks B G; Li R; Arnaout M A; Golenbock D T; Freeman M W
Divergent response to LPS and bacteria in CD14-deficient murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4272-80.
2000: Means T K; Golenbock D T; Fenton M J
The biology of Toll-like receptors.
Cytokine & growth factor reviews 2000;11(3):219-32.
2000: Lien E; Means T K; Heine H; Yoshimura A; Kusumoto S; Fukase K; Fenton M J; Oikawa M; Qureshi N; Monks B; Finberg R W; Ingalls R R; Golenbock D T
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
The Journal of clinical investigation 2000;105(4):497-504.
2000: Flo T H; Halaas O; Lien E; Ryan L; Teti G; Golenbock D T; Sundan A; Espevik T
Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):2064-9.
2000: Ingalls R R; Lien E; Golenbock D T
Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis.
Journal of endotoxin research 2000;6(5):411-5.
2000: Yoshimura A; Takada H; Kaneko T; Kato I; Golenbock D; Hara Y
Structural requirements of muramylpeptides for induction of Toll-like receptor 2-mediated NF-kappaB activation in CHO cells.
Journal of endotoxin research 2000;6(5):407-10.
1999: Means T K; Lien E; Yoshimura A; Wang S; Golenbock D T; Fenton M J
The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6748-55.
1999: Lien E; Sellati T J; Yoshimura A; Flo T H; Rawadi G; Finberg R W; Carroll J D; Espevik T; Ingalls R R; Radolf J D; Golenbock D T
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
The Journal of biological chemistry 1999;274(47):33419-25.
1999: Means T K; Wang S; Lien E; Yoshimura A; Golenbock D T; Fenton M J
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3920-7.
1999: Heine H; Delude R L; Monks B G; Espevik T; Golenbock D T
Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.
The Journal of biological chemistry 1999;274(30):21049-55.
1999: Yoshimura A; Lien E; Ingalls R R; Tuomanen E; Dziarski R; Golenbock D
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):1-5.
1999: Bhat N; Perera P Y; Carboni J M; Blanco J; Golenbock D T; Mayadas T N; Vogel S N
Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7335-42.
1999: Heine H; Kirschning C J; Lien E; Monks B G; Rothe M; Golenbock D T
Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):6971-5.
1999: Ingalls R R; Heine H; Lien E; Yoshimura A; Golenbock D
Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.
Infectious disease clinics of North America 1999;13(2):341-53, vii.
1999: Ingalls R R; Monks B G; Golenbock D T
Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14.
The Journal of biological chemistry 1999;274(20):13993-8.
1998: Ingalls R R; Monks B G; Savedra R; Christ W J; Delude R L; Medvedev A E; Espevik T; Golenbock D T
CD11/CD18 and CD14 share a common lipid A signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5413-20.
1998: Bliss C M; Golenbock D T; Keates S; Linevsky J K; Kelly C P
Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes.
Infection and immunity 1998;66(11):5357-63.
1998: Delude R L; Yoshimura A; Ingalls R R; Golenbock D T
Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):3001-9.
1998: Fenton M J; Golenbock D T
LPS-binding proteins and receptors.
Journal of leukocyte biology 1998;64(1):25-32.
1998: Medvedev A E; Flo T; Ingalls R R; Golenbock D T; Teti G; Vogel S N; Espevik T
Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4535-42.
1998: Ingalls R R; Arnaout M A; Delude R L; Flaherty S; Savedra R; Golenbock D T
The CD11/CD18 integrins: characterization of three novel LPS signaling receptors.
Progress in clinical and biological research 1998;397():107-17.
1997: Wurfel M M; Monks B G; Ingalls R R; Dedrick R L; Delude R; Zhou D; Lamping N; Schumann R R; Thieringer R; Fenton M J; Wright S D; Golenbock D
Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.
The Journal of experimental medicine 1997;186(12):2051-6.
1997: Flaherty S F; Golenbock D T; Milham F H; Ingalls R R
CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin.
The Journal of surgical research 1997;73(1):85-9.
1997: Pollack M; Ohl C A; Golenbock D T; Di Padova F; Wahl L M; Koles N L; Guelde G; Monks B G
Dual effects of LPS antibodies on cellular uptake of LPS and LPS-induced proinflammatory functions.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3519-30.
1997: Ingalls R R; Arnaout M A; Golenbock D T
Outside-in signaling by lipopolysaccharide through a tailless integrin.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):433-8.
1997: Levitz S M; Tabuni A; Kozel T R; MacGill R S; Ingalls R R; Golenbock D T
Binding of Cryptococcus neoformans to heterologously expressed human complement receptors.
Infection and immunity 1997;65(3):931-5.
1997: Lodie T A; Savedra R; Golenbock D T; Van Beveren C P; Maki R A; Fenton M J
Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1848-56.
1996: Savedra R; Delude R L; Ingalls R R; Fenton M J; Golenbock D T
Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2549-54.
1996: Levitz S M; Tabuni A; Nong S H; Golenbock D T
Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.
Infection and immunity 1996;64(3):945-51.
1995: Delude R L; Savedra R; Zhao H; Thieringer R; Yamamoto S; Fenton M J; Golenbock D T
CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9288-92.
1995: Ingalls R R; Rice P A; Qureshi N; Takayama K; Lin J S; Golenbock D T
The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated.
Infection and immunity 1995;63(8):3125-30.
1995: Ingalls R R; Golenbock D T
CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.
The Journal of experimental medicine 1995;181(4):1473-9.
1995: Delude R L; Savedra R; Yamamoto S; Golenbock D T
Use of CD14 transfected cells to study LPS-antagonist action.
Progress in clinical and biological research 1995;392():487-97.
1994: Delude R L; Fenton M J; Savedra R; Perera P Y; Vogel S N; Thieringer R; Golenbock D T
CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
The Journal of biological chemistry 1994;269(35):22253-60.
1994: Levitz S M; Tabuni A; Kornfeld H; Reardon C C; Golenbock D T
Production of tumor necrosis factor alpha in human leukocytes stimulated by Cryptococcus neoformans.
Infection and immunity 1994;62(5):1975-81.
1993: Golenbock D T; Liu Y; Millham F H; Freeman M W; Zoeller R A
Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.
The Journal of biological chemistry 1993;268(29):22055-9.
1991: Golenbock D T; Hampton R Y; Qureshi N; Takayama K; Raetz C R
Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.
The Journal of biological chemistry 1991;266(29):19490-8.
1991: Hampton R Y; Golenbock D T; Penman M; Krieger M; Raetz C R
Recognition and plasma clearance of endotoxin by scavenger receptors.
Nature 1991;352(6333):342-4.
1990: Golenbock D T; Hampton R Y; Raetz C R; Wright S D
Human phagocytes have multiple lipid A-binding sites.
Infection and immunity 1990;58(12):4069-75.
1988: Hampton R Y; Golenbock D T; Raetz C R
Lipid A binding sites in membranes of macrophage tumor cells.
The Journal of biological chemistry 1988;263(29):14802-7.
1988: Golenbock D T; Leggett J E; Rasmussen P; Craig W A; Raetz C R; Proctor R A
Lipid X protects mice against fatal Escherichia coli infection.
Infection and immunity 1988;56(4):779-84.
1988: Golenbock D T; Ebert S; Will J A; Proctor R A
Elimination and tissue distribution of the monosaccharide lipid A precursor, lipid X, in mice and sheep.
Antimicrobial agents and chemotherapy 1988;32(1):37-41.
1988: Raetz C R; Brozek K A; Clementz T; Coleman J D; Galloway S M; Golenbock D T; Hampton R Y
Gram-negative endotoxin: a biologically active lipid.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():973-82.
1987: Golenbock D T; Will J A; Raetz C R; Proctor R A
Lipid X ameliorates pulmonary hypertension and protects sheep from death due to endotoxin.
Infection and immunity 1987;55(10):2471-6.

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