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Lorne Golub

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Ying Gu; Jeffrey B Payne; Maria E Ryan; Clay Walker; Lorne M Golub
Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine.
Yu Zhang; Lorne M Golub; Francis Johnson; Arnold Wishnia
pKa, zinc- and serum albumin-binding of curcumin and two novel biologically-active chemically-modified curcumins.
Yu Zhang; Kveta Vranková; Hsi-Ming Lee; Lorne M Golub; Ying Gu; Elena Hambardjieva; Francis Johnson
Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins.

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All Publications

2012: Ying Gu; Jeffrey B Payne; Maria E Ryan; Clay Walker; Lorne M Golub
Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine.
Journal of oral microbiology 2012;4():.
2012: Yu Zhang; Lorne M Golub; Francis Johnson; Arnold Wishnia
pKa, zinc- and serum albumin-binding of curcumin and two novel biologically-active chemically-modified curcumins.
Current medicinal chemistry 2012;19(25):4367-75.
2012: Yu Zhang; Kveta Vranková; Hsi-Ming Lee; Lorne M Golub; Ying Gu; Elena Hambardjieva; Francis Johnson
Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins.
Current medicinal chemistry 2012;19(25):4348-58.
2011: Ying Gu; Hsi-Ming Lee; Maria E Ryan; Aino Salminen; Marvin J Slepian; Timo Sorsa; Lorne M Golub
Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: a mechanistic link between local and systemic inflammation.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(6):573-9.
2011: Lorne M Golub; Robert A Greenwald
Clinical applications of non-antibacterial tetracyclines. Part II.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(6):549-50.
2011: Ying Gu; Hsi-Ming Lee; Sanford R Simon; Lorne M Golub
Chemically modified tetracycline-3 (CMT-3): a novel inhibitor of the serine proteinase, elastase.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(6):595-601.
2011: Lorne M Golub
Introduction and background.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(2):99-101.
2010: Lorne M Golub; Hsi-Ming Lee; J A Stoner; Richard A Reinhardt; Timo Sorsa; A D Goren; Jeffrey B Payne
Doxycycline effects on serum bone biomarkers in post-menopausal women.
Journal of dental research 2010;89(6):644-9.
2010: Ying Gu; Hsi-Ming Lee; Timo Sorsa; Sanford R Simon; Lorne M Golub
Doxycycline [corrected] inhibits mononuclear cell-mediated connective tissue breakdown.
FEMS immunology and medical microbiology 2010;58(2):218-25.
2008: Arthur D Goren; Stanley M Dunn; Mark Wolff; Paul F van der Stelt; Dan C Colosi; Lorne M Golub
Pilot study: digital subtraction radiography as a tool to assess alveolar bone changes in periodontitis patients under treatment with subantimicrobial doses of doxycycline.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2008;106(4):e40-5.
2008: Lorne M Golub; Hsi-Ming Lee; Julie A Stoner; Timo Sorsa; Richard A Reinhardt; Mark S Wolff; Maria E Ryan; Pirkka V Nummikoski; Jeffrey B Payne
Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women.
Journal of periodontology 2008;79(8):1409-18.
2008: Ling Xu; Zhao Yu; Hsi-Ming Lee; Mark S Wolff; Lorne M Golub; Timo Sorsa; Heidi Kuula
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study.
Acta odontologica Scandinavica 2008;66(4):219-24.
2007: Markus J Leskinen; Kari K Eklund; Timo Sorsa; Lorne M Golub; Petri T Kovanen; Ken A Lindstedt
Inhibition of smooth muscle cell proliferation by a chemically modified tetracycline.
Coronary artery disease 2007;18(8):663-7.
2007: Gülay Tüter; Bülent Kurtiş; Muhittin Serdar; Tuba Aykan; Kaan Okyay; Aysegül Yücel; Utku Toyman; Selin Pinar; Mustafa Cemri; Atiye Cengel; Stephen G Walker; Lorne M Golub
Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease.
Journal of clinical periodontology 2007;34(8):673-81.
2006: Timo Sorsa; Leo Tjäderhane; Yrjö T Konttinen; Anneli Lauhio; Tuula Salo; Hsi-Ming Lee; Lorne M Golub; David L Brown; Päivi Mäntylä
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.
Annals of medicine 2006;38(5):306-21.
2005: Salih S Kocer; Stephen G Walker; Brad Zerler; Lorne M Golub; Sanford R Simon
Metalloproteinase inhibitors, nonantimicrobial chemically modified tetracyclines, and ilomastat block Bacillus anthracis lethal factor activity in viable cells.
Infection and immunity 2005;73(11):7548-57.
2005: Charlotta Sandler; Katariina Nurmi; Ken A Lindstedt; Timo Sorsa; Lorne M Golub; Petri T Kovanen; Kari K Eklund
Chemically modified tetracyclines induce apoptosis in cultured mast cells.
International immunopharmacology 2005;5(11):1611-21.
2005: Charlotta Sandler; Elina Ekokoski; Ken A Lindstedt; Petri J Vainio; Moshe Finel; Timo Sorsa; Petri T Kovanen; Lorne M Golub; Kari K Eklund
Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54(7):304-12.
2004: Hsi-Ming Lee; Sebastian G Ciancio; Gülay Tüter; Maria E Ryan; Eugene Komaroff; Lorne M Golub
Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug.
Journal of periodontology 2004;75(3):453-63.
2002: Nungavaram S Ramamurthy; Barry R Rifkin; Robert Greenwald; Jing-Wen Xu; Yu Liu; Gloria Turner; Lorne M Golub; Anthony T Vernillo
Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines.
Journal of periodontology 2002;73(7):726-34.
2002: Yu Liu; George Tortora; Maria E Ryan; Hsi-Ming Lee; Lorne M Golub
Potato dextrose agar antifungal susceptibility testing for yeasts and molds: evaluation of phosphate effect on antifungal activity of CMT-3.
Antimicrobial agents and chemotherapy 2002;46(5):1455-61.
2002: Yu Liu; Maria E Ryan; Hsi-Ming Lee; Sanford Simon; George Tortora; Carol Lauzon; Michael K Leung; Lorne M Golub
A chemically modified tetracycline (CMT-3) is a new antifungal agent.
Antimicrobial agents and chemotherapy 2002;46(5):1447-54.
2002: Emma Pirilä; Mataleena Parikka; Nungavaram S Ramamurthy; Päivi Maisi; Steve McClain; Allan Kucine; Taina Tervahartiala; Kaiu Prikk; Lorne M Golub; Tuula Salo; Timo Sorsa
Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 gamma2-chain.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2002;10(1):38-51.
2002: Daniel Grenier; Pascale Plamondon; T Sorsa; H M Lee; TF McNamara; Nungavaram S Ramamurthy; Lorne M Golub; Olli Teronen; Denis Mayrand
Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives.
Journal of periodontology 2002;73(1):79-85.
2001: Jack G Caton; Sebastian Ciancio; M Ryan; Lorne M Golub; Timothy M Blieden; J Thomas; Clay Walker
Doxycycline dosing.
Journal of the American Dental Association (1939) 2001;132(10):1366, 1368, 1370.
2001: A Llavaneras; Nungavaram S Ramamurthy; P Heikkilä; Olli Teronen; Tuula Salo; Barry R Rifkin; Maria E Ryan; Lorne M Golub; Timo Sorsa
A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.
Journal of periodontology 2001;72(8):1069-77.
2001: Maria E Ryan; A Usman; Nungavaram S Ramamurthy; Lorne M Golub; Robert Greenwald
Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity.
Current medicinal chemistry 2001;8(3):305-16.
2001: Nungavaram S Ramamurthy; S Bain; C T Liang; J Barnes; A Llavaneras; Yu Liu; D Puerner; M J Strachan; Lorne M Golub
A combination of subtherapeutic doses of chemically modified doxycycline (CMT-8) and a bisphosphonate (clodronate) inhibits bone loss in the ovariectomized rat: a dynamic histomorphometric and gene expression study.
Current medicinal chemistry 2001;8(3):295-303.
2001: Emma Pirilä; Nungavaram S Ramamurthy; Päivi Maisi; Steve McClain; Allan Kucine; Jaana Wahlgren; Lorne M Golub; Tuula Salo; Timo Sorsa
Wound healing in ovariectomized rats: effects of chemically modified tetracycline (CMT-8) and estrogen on matrix metalloproteinases -8, -13 and type I collagen expression.
Current medicinal chemistry 2001;8(3):281-94.
2001: Hsi-Ming Lee; Lorne M Golub; J Cao; Olli Teronen; Minna Laitinen; Tuula Salo; S Zucker; Timo Sorsa
CMT-3, a non-antimicrobial tetracycline (TC), inhibits MT1-MMP activity: relevance to cancer.
Current medicinal chemistry 2001;8(3):257-60.
2001: J Chen; M Bookbinder; Maria E Ryan; Lorne M Golub; R Ashley; Nungavaram S Ramamurthy
Biodistribution of radiolabeled [(3)H] CMT-3 in rats.
Current medicinal chemistry 2001;8(3):253-6.
2001: Yu Liu; Nungavaram S Ramamurthy; J Marecek; Hsi-Ming Lee; J L Chen; Maria E Ryan; Barry R Rifkin; Lorne M Golub
The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs).
Current medicinal chemistry 2001;8(3):243-52.
2001: Robert Greenwald; Lorne M Golub
Biologic properties of non-antibiotic, chemically modified tetracyclines (CMTs): a structured, annotated bibliography.
Current medicinal chemistry 2001;8(3):237-42.
2001: Lorne M Golub; TF McNamara; Maria E Ryan; B Kohut; T Blieden; G Payonk; T Sipos; H J Baron
Adjunctive treatment with subantimicrobial doses of doxycycline: effects on gingival fluid collagenase activity and attachment loss in adult periodontitis.
Journal of clinical periodontology 2001;28(2):146-56.
2000: Maria E Ryan; Lorne M Golub
Modulation of matrix metalloproteinase activities in periodontitis as a treatment strategy.
Periodontology 2000 2000;24():226-38.
2000: A Lukkonen; Timo Sorsa; Tuula Salo; Taina Tervahartiala; Erkki Koivunen; Lorne M Golub; S Simon; Ulf-Hakan Stenman
Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration.
International journal of cancer. Journal international du cancer 2000;86(4):577-81.
1999: David E Carney; Charles J Lutz; Anthony Picone; Louis A Gatto; Nungavaram S Ramamurthy; Lorne M Golub; S R Simon; Bruce Searles; AM Paskanik; K Snyder; CM Finck; Henry J Schiller; Gary F Nieman
Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass.
Circulation 1999;100(4):400-6.
1999: Nungavaram S Ramamurthy; Steve McClain; E Pirila; Päivi Maisi; Tuula Salo; Allan Kucine; Timo Sorsa; F Vishram; Lorne M Golub
Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis.
Annals of the New York Academy of Sciences 1999;878():720-3.
1999: A Llavaneras; Lorne M Golub; Barry R Rifkin; P Heikkilä; Timo Sorsa; Olli Teronen; Tuula Salo; Yu Liu; Maria E Ryan; Nungavaram S Ramamurthy
CMT-8/clodronate combination therapy synergistically inhibits alveolar bone loss in LPS-induced periodontitis.
Annals of the New York Academy of Sciences 1999;878():671-4.
1999: Takahisa Sasaki; N Ohyori; Kazuhiro Debari; Nungavaram S Ramamurthy; Lorne M Golub
Effects of chemically modified tetracycline, CMT-8, on bone loss and osteoclast structure and function in osteoporotic states.
Annals of the New York Academy of Sciences 1999;878():347-60.
1999: Maria E Ryan; Nungavaram S Ramamurthy; T Sorsa; Lorne M Golub
MMP-mediated events in diabetes.
Annals of the New York Academy of Sciences 1999;878():311-34.
1999: Lorne M Golub; Nungavaram S Ramamurthy; A Llavaneras; Maria E Ryan; Hsi-Ming Lee; Yu Liu; S Bain; Timo Sorsa
A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats.
Annals of the New York Academy of Sciences 1999;878():290-310.
1999: Timo Sorsa; Päivi Mäntylä; H Rönkä; P Kallio; G B Kallis; C Lundqvist; Denis F Kinane; Tuula Salo; Lorne M Golub; Olli Teronen; Sari Tikanoja
Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease.
Annals of the New York Academy of Sciences 1999;878():130-40.
1998: Lorne M Golub; H W Kaufman
Israel Kleinberg: oral biology north and south.
Journal of dental research 1998;77(12):1956-9.
1998: Maria E Ryan; Nungavaram S Ramamurthy; Lorne M Golub
Tetracyclines inhibit protein glycation in experimental diabetes.
Advances in dental research 1998;12(2):152-8.
1998: Nungavaram S Ramamurthy; Allan Kucine; Steve McClain; TF McNamara; Lorne M Golub
Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin.
Advances in dental research 1998;12(2):144-8.
1998: T Sasaki; Nungavaram S Ramamurthy; Lorne M Golub
Long-term therapy with a new chemically modified tetracycline (CMT-8) inhibits bone loss in femurs of ovariectomized rats.
Advances in dental research 1998;12(2):76-81.
1998: Howard A Israel; Nungavaram S Ramamurthy; Robert Greenwald; Lorne M Golub
The potential role of doxycycline in the treatment of osteoarthritis of the temporomandibular joint.
Advances in dental research 1998;12(2):51-5.
1998: Nungavaram S Ramamurthy; K L Schroeder; TF McNamara; A J Gwinnett; R T Evans; C Bosko; Lorne M Golub
Root-surface caries in rats and humans: inhibition by a non-antimicrobial property of tetracyclines.
Advances in dental research 1998;12(2):43-50.
1998: Lorne M Golub; Hsi-Ming Lee; Maria E Ryan; W V Giannobile; J Payne; Timo Sorsa
Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms.
Advances in dental research 1998;12(2):12-26.
1998: Waldemar Pruzanski; E Stefanski; Peter Vadas; TF McNamara; Nungavaram S Ramamurthy; Lorne M Golub
Chemically modified non-antimicrobial tetracyclines inhibit activity of phospholipases A2.
The Journal of rheumatology 1998;25(9):1807-12.
1998: Timo Sorsa; Nungavaram S Ramamurthy; Anthony T Vernillo; X Zhang; Y T Konttinen; Barry R Rifkin; Lorne M Golub
Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases.
The Journal of rheumatology 1998;25(5):975-82.
1998: Ronald G Craig; Z Yu; L Xu; R Barr; Nungavaram S Ramamurthy; J Boland; M Schneir; Lorne M Golub
A chemically modified tetracycline inhibits streptozotocin-induced diabetic depression of skin collagen synthesis and steady-state type I procollagen mRNA.
Biochimica et biophysica acta 1998;1402(3):250-60.
1998: Richard E B Seftor; Elisabeth A Seftor; J E De Larco; D E Kleiner; J Leferson; William Stetler-Stevenson; T F McNamara; Lorne M Golub; Mary J C Hendrix
Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis.
Clinical & experimental metastasis 1998;16(3):217-25.
1998: Nadeem Y Karimbux; Nungavaram S Ramamurthy; Lorne M Golub; Ichiro Nishimura
The expression of collagen I and XII mRNAs in Porphyromonas gingivalis-induced periodontitis in rats: the effect of doxycycline and chemically modified tetracycline.
Journal of periodontology 1998;69(1):34-40.
1998: Robert Greenwald; Lorne M Golub; Nungavaram S Ramamurthy; M Chowdhury; SA Moak; Timo Sorsa
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Bone 1998;22(1):33-8.
1997: Lorne M Golub; Hsi-Ming Lee; Robert Greenwald; Maria E Ryan; Timo Sorsa; Tuula Salo; W V Giannobile
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(8):310-9.
1997: S Bain; Nungavaram S Ramamurthy; T Impeduglia; S Scolman; Lorne M Golub; C Rubin
Tetracycline prevents cancellous bone loss and maintains near-normal rates of bone formation in streptozotocin diabetic rats.
Bone 1997;21(2):147-53.
1997: Ronald F Zernicke; Gregory R Wohl; Robert Greenwald; SA Moak; W Leng; Lorne M Golub
Administration of systemic matrix metalloproteinase inhibitors maintains bone mechanical integrity in adjuvant arthritis.
The Journal of rheumatology 1997;24(7):1324-31.
1997: Hsi-Ming Lee; Lorne M Golub; D Chan; M Leung; K Schroeder; M Wolff; S Simon; R Crout
alpha 1-Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition by doxycycline.
Journal of periodontal research 1997;32(1 Pt 1):9-19.
1996: K M Chang; M E Ryan; Lorne M Golub; Nungavaram S Ramamurthy; TF McNamara
Local and systemic factors in periodontal disease increase matrix-degrading enzyme activities in rat gingiva: effect of micocycline therapy.
Research communications in molecular pathology and pharmacology 1996;91(3):303-18.
1995: M K Leung; Robert Greenwald; Nungavaram S Ramamurthy; SA Moak; R Koszulinski; D Dieudonne; Lorne M Golub
Tenidap and flurbiprofen enhance uptake of matrix metalloproteinase inhibitor 4-dedimethylaminotetracycline in inflamed joints of adjuvant arthritic rats.
The Journal of rheumatology 1995;22(9):1726-31.
1994: Anneli Lauhio; Tuula Salo; Y Ding; Yrjö T Konttinen; Dan Nordström; H Tschesche; J Lähdevirta; Lorne M Golub; Timo Sorsa
In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis.
Clinical and experimental immunology 1994;98(1):21-8.
1994: Lorne M Golub; R T Evans; TF McNamara; H M Lee; Nungavaram S Ramamurthy
A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis-induced periodontitis in rats.
Annals of the New York Academy of Sciences 1994;732():96-111.
1994: Anneli Lauhio; Yrjö T Konttinen; Tuula Salo; H Tschesche; Dan Nordström; J Lähdevirta; Lorne M Golub; Timo Sorsa
The in vivo effect of doxycycline treatment on matrix metalloproteinases in reactive arthritis.
Annals of the New York Academy of Sciences 1994;732():431-2.
1994: Nungavaram S Ramamurthy; Robert Greenwald; S Moak; J Scuibba; A Goren; G Turner; B Rifkin; Lorne M Golub
CMT/Tenidap treatment inhibits temporomandibular joint destruction in adjuvant arthritic rats.
Annals of the New York Academy of Sciences 1994;732():427-30.
1994: Anneli Lauhio; Yrjö T Konttinen; Tuula Salo; H Tschesche; J Lähdevirta; F Woessner; Lorne M Golub; Timo Sorsa
Placebo-controlled study of the effects of three-month lymecycline treatment on serum matrix metalloproteinases in reactive arthritis.
Annals of the New York Academy of Sciences 1994;732():424-6.
1994: Robert Greenwald; SA Moak; Lorne M Golub
Low dose doxycycline inhibits pyridinoline excretion in selected patients with rheumatoid arthritis.
Annals of the New York Academy of Sciences 1994;732():419-21.
1994: Barry R Rifkin; Anthony T Vernillo; Lorne M Golub; Nungavaram S Ramamurthy
Modulation of bone resorption by tetracyclines.
Annals of the New York Academy of Sciences 1994;732():165-80.
1994: K M Chang; Nungavaram S Ramamurthy; TF McNamara; R T Evans; B Klausen; P A Murray; Lorne M Golub
Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism.
Journal of periodontal research 1994;29(4):242-9.
1994: Lorne M Golub; M Wolff; S Roberts; Hsi-Ming Lee; M Leung; G S Payonk
Treating periodontal diseases by blocking tissue-destructive enzymes.
Journal of the American Dental Association (1939) 1994;125(2):163-9; discussion 169-71.
1994: Anthony T Vernillo; Nungavaram S Ramamurthy; Lorne M Golub; Barry R Rifkin
The nonantimicrobial properties of tetracycline for the treatment of periodontal disease.
Current opinion in periodontology 1994;():111-8.
1993: Nungavaram S Ramamurthy; M Leung; S Moak; Robert Greenwald; Lorne M Golub
CMT/NSAID combination increases bone CMT uptake and inhibits bone resorption.
Annals of the New York Academy of Sciences 1993;696():420-1.
1993: Z Yu; Nungavaram S Ramamurthy; M Leung; K M Chang; TF McNamara; Lorne M Golub
Chemically-modified tetracycline normalizes collagen metabolism in diabetic rats: a dose-response study.
Journal of periodontal research 1993;28(6 Pt 1):420-8.
1993: Nungavaram S Ramamurthy; Anthony T Vernillo; Robert Greenwald; Hsi-Ming Lee; Timo Sorsa; Lorne M Golub; Barry R Rifkin
Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(10):1247-53.
1993: Anneli Lauhio; Timo Sorsa; O Lindy; K Suomalainen; H Saari; Lorne M Golub; Y T Konttinen
The regulatory role of doxycycline/tetracycline in collagenolytic activity and tissue destruction in joint diseases: comment on the article by Yu et al.
Arthritis and rheumatism 1993;36(9):1335-6.
1993: Barry R Rifkin; Anthony T Vernillo; Lorne M Golub
Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs.
Journal of periodontology 1993;64(8 Suppl):819-27.
1993: Timo Sorsa; O Lindy; Yrjö T Konttinen; K Suomalainen; Tuula Ingman; H Saari; S Halinen; H M Lee; Lorne M Golub; J Hall
Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase.
Antimicrobial agents and chemotherapy 1993;37(3):592-4.
1993: Tuula Ingman; Timo Sorsa; K Suomalainen; S Halinen; O Lindy; Anneli Lauhio; H Saari; Yrjö T Konttinen; Lorne M Golub
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article.
Journal of periodontology 1993;64(2):82-8.
1993: Timo Sorsa; Yrjö T Konttinen; O Lindy; K Suomalainen; Tuula Ingman; H Saari; S Halinen; H M Lee; Lorne M Golub; J Hall
Doxycycline protects serum alpha-1-antitrypsin from human neutrophil collagenase.
Agents and actions. Supplements 1993;39():225-9.
1992: B S Schneider; J Maimon; Lorne M Golub; Nungavaram S Ramamurthy; Robert Greenwald
Tetracyclines inhibit intracellular muscle proteolysis in vitro.
Biochemical and biophysical research communications 1992;188(2):767-72.
1992: Robert Greenwald; SA Moak; Nungavaram S Ramamurthy; Lorne M Golub
Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage.
The Journal of rheumatology 1992;19(6):927-38.
1992: K Suomalainen; Timo Sorsa; Tuula Ingman; O Lindy; Lorne M Golub
Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo.
Oral microbiology and immunology 1992;7(2):121-3.
1992: Timo Sorsa; Tuula Ingman; K Suomalainen; S Halinen; H Saari; Yrjö T Konttinen; Veli-Jukka Uitto; Lorne M Golub
Cellular source and tetracycline-inhibition of gingival crevicular fluid collagenase of patients with labile diabetes mellitus.
Journal of clinical periodontology 1992;19(2):146-9.
1992: Z Yu; M K Leung; Nungavaram S Ramamurthy; TF McNamara; Lorne M Golub
HPLC determination of a chemically modified nonantimicrobial tetracycline: biological implications.
Biochemical medicine and metabolic biology 1992;47(1):10-20.
1992: Anneli Lauhio; Timo Sorsa; O Lindy; K Suomalainen; H Saari; Lorne M Golub; Yrjö T Konttinen
The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis.
Arthritis and rheumatism 1992;35(2):195-8.
1992: Lorne M Golub; Robert Greenwald; Nungavaram S Ramamurthy; S Zucker; L Ramsammy; T McNamara
Tetracyclines (TCs) inhibit matrix metalloproteinases (MMPs): in vivo effects in arthritic and diabetic rats and new in vitro studies.
Matrix (Stuttgart, Germany). Supplement 1992;1():315-6.
1992: K Suomalainen; S Halinen; Tuula Ingman; O Lindy; H Saari; Yrjö T Konttinen; Lorne M Golub; Timo Sorsa
Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases.
Drugs under experimental and clinical research 1992;18(3):99-104.
1992: K Suomalainen; Timo Sorsa; Lorne M Golub; Nungavaram S Ramamurthy; H M Lee; Veli-Jukka Uitto; H Saari; Yrjö T Konttinen
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
Antimicrobial agents and chemotherapy 1992;36(1):227-9.
1991: Lorne M Golub; Nungavaram S Ramamurthy; TF McNamara; Robert Greenwald; Barry R Rifkin
Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 1991;2(3):297-321.
1990: Nungavaram S Ramamurthy; Anthony T Vernillo; H M Lee; Lorne M Golub; Barry R Rifkin
The effect of tetracyclines on collagenase activity in UMR 106-01 rat osteoblastic osteosarcoma cells.
Research communications in chemical pathology and pharmacology 1990;70(3):323-35.
1990: Lorne M Golub; S Ciancio; N S Ramamamurthy; M Leung; TF McNamara
Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans.
Journal of periodontal research 1990;25(6):321-30.
1990: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Minocycline-treatment of diabetic rats normalizes skin collagen production and mass: possible causative mechanisms.
Matrix (Stuttgart, Germany) 1990;10(2):112-23.
1990: Lorne M Golub; Nungavaram S Ramamurthy; H Kaneko; T Sasaki; Barry R Rifkin; TF McNamara
Tetracycline administration prevents diabetes-induced osteopenia in the rat: initial observations.
Research communications in chemical pathology and pharmacology 1990;68(1):27-40.
1988: K M Chang; Nungavaram S Ramamurthy; TF McNamara; R J Genco; Lorne M Golub
Infection with a gram-negative organism stimulates gingival collagenase production in non-diabetic and diabetic germfree rats.
Journal of periodontal research 1988;23(4):239-44.
1988: M Schneir; M Imberman; Nungavaram S Ramamurthy; Lorne M Golub
Streptozotocin-induced diabetes and the rat periodontium: decreased relative collagen production.
Collagen and related research 1988;8(3):221-32.
1988: Robert Greenwald; B G Simonson; SA Moak; S W Rush; Nungavaram S Ramamurthy; R S Laskin; Lorne M Golub
Inhibition of epiphyseal cartilage collagenase by tetracyclines in low phosphate rickets in rats.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1988;6(5):695-703.
1987: Lorne M Golub; TF McNamara; G D'Angelo; Robert Greenwald; Nungavaram S Ramamurthy
A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity.
Journal of dental research 1987;66(8):1310-4.
1987: Robert Greenwald; Lorne M Golub; B Lavietes; Nungavaram S Ramamurthy; B Gruber; R S Laskin; TF McNamara
Tetracyclines inhibit human synovial collagenase in vivo and in vitro.
The Journal of rheumatology 1987;14(1):28-32.
1986: M Imberman; Nungavaram S Ramamurthy; Lorne M Golub; M Schneir
A reassessment of collagen half-life in rat periodontal tissues: application of the pool-expansion approach.
Journal of periodontal research 1986;21(4):396-402.
1986: M K Leung; G A Folkes; Nungavaram S Ramamurthy; M Schneir; Lorne M Golub
Diabetes stimulates procollagen degradation in rat tendon in vitro.
Biochimica et biophysica acta 1986;880(2-3):147-52.
1986: M Schneir; M Imberman; Nungavaram S Ramamurthy; Lorne M Golub
The in vivo fractional rate of gingival collagen production in non-diabetic and diabetic rats. Application of a novel approach for quantification-pool expansion.
Journal of periodontal research 1986;21(1):56-63.
1985: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Dietary ascorbic acid normalizes diabetes-induced underhydroxylation of nascent type I collagen molecules.
Collagen and related research 1985;5(5):415-22.
1985: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Enhanced intracellular procollagen degradation in skins of streptozotocin-induced diabetic rats: a causal relationship to underhydroxylation.
Progress in clinical and biological research 1985;180():667-8.
1985: Nungavaram S Ramamurthy; Robert Greenwald; M Schneir; Lorne M Golub
The effect of alloxan diabetes on prolyl and lysyl hydroxylase activity in uninflamed and inflamed rat gingiva.
Archives of oral biology 1985;30(9):679-83.
1984: Lorne M Golub; Nungavaram S Ramamurthy; T F McNamara; B Gomes; M Wolff; A Casino; A Kapoor; J Zambon; S Ciancio; M Schneir
Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease.
Journal of periodontal research 1984;19(6):651-5.
1984: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Skin collagen metabolism in the streptozotocin-induced diabetic rat: free hydroxyproline, the principal in vivo degradation product of newly synthesized collagen--probably procollagen.
Collagen and related research 1984;4(3):183-93.
1984: M L Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Extensive degradation of recently synthesized collagen in gingiva of normal and streptozotocin-induced diabetic rats.
Journal of dental research 1984;63(1):23-7.
1982: M Schneir; Nungavaram S Ramamurthy; Lorne M Golub
Skin collagen metabolism in the streptozotocin-induced diabetic rat. Enhanced catabolism of collagen formed both before and during the diabetic state.
Diabetes 1982;31(5 Pt 1):426-31.