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Adrian Gombart

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Chunxiao Guo; Malcolm B Lowry; Elena Rosoha; Niels Borregaard; Adrian F Gombart
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.
Yan Campbell; Mary L Fantacone; Adrian F Gombart
Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism.
Pierre Kyme; Kunik Lee; Wolfgang E Berdel; Adrian F Gombart; W David Hardy; H Phillip Koeffler; Utz O Krug; Carsten Müller-Tidow; Kenichi Shimada; Gabriela B Thoennissen; Nils H Thoennissen; Ching Wen Tseng; Andrea J Wolf; George Y Liu
C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.

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All Publications

2013: Chunxiao Guo; Malcolm B Lowry; Elena Rosoha; Niels Borregaard; Adrian F Gombart
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.
The Journal of nutritional biochemistry 2013;24(5):754-9.
2012: Yan Campbell; Mary L Fantacone; Adrian F Gombart
Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism.
European journal of nutrition 2012;51(8):899-907.
2012: Pierre Kyme; Kunik Lee; Wolfgang E Berdel; Adrian F Gombart; W David Hardy; H Phillip Koeffler; Utz O Krug; Carsten Müller-Tidow; Kenichi Shimada; Gabriela B Thoennissen; Nils H Thoennissen; Ching Wen Tseng; Andrea J Wolf; George Y Liu
C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.
The Journal of clinical investigation 2012;122(9):3316-29.
2012: Guihua Sun; Xiwei Wu; Lisa Scherer; Jessica Alluin; Pritsana Chomchan; Maricela Covarrubias; Adrian F Gombart; Haitang Li; Brian Luk; Keith Meinking; John J Rossi
Interplay between HIV-1 infection and host microRNAs.
Nucleic acids research 2012;40(5):2181-96.
2012: Brian M Dixon; Balz Frei; Tyler Barker; Niels Borregaard; John Cuomo; Toni McKinnon; Adrian F Gombart
Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults.
BMC research notes 2012;5():575.
2010: Tadayuki Akagi; Nils H Thoennissen; Ann George; Gay Crooks; Jee Hoon Song; Ryoko Okamoto; Daniel Nowak; Adrian F Gombart; H Phillip Koeffler
In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.
PloS one 2010;5(11):e15419.
2009: Adrian F Gombart
The vitamin D-antimicrobial peptide pathway and its role in protection against infection.
Future microbiology 2009;4(9):1151-65.
2009: John S Adams; Songyang Ren; Philip T Liu; Rene Chun; Venu Lagishetty; Adrian F Gombart; Niels Borregaard; Robert L Modlin; Martin Hewison
Vitamin d-directed rheostatic regulation of monocyte antibacterial responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4289-95.
2009: Adrian F Gombart; Ishir Bhan; Niels Borregaard; Hector Tamez; Carlos A Camargo; H Phillip Koeffler; Ravi Thadhani
Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;48(4):418-24.
2009: Andy Uh; Charles F Simmons; Catherine Bresee; Nasif Khoury; Adrian F Gombart; Richard C Nicholson; Hande Kocak; Ozlem Equils
MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell line.
Reproductive biology and endocrinology : RB&E 2009;7():74.
2009: Adrian F Gombart; Tsuyako Saito; H Phillip Koeffler
Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
BMC genomics 2009;10():321.
2008: Tadayuki Akagi; Takayuki Saitoh; James O'Kelly; Shizuo Akira; Adrian F Gombart; H Phillip Koeffler
Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells.
Blood 2008;111(6):2999-3004.
2007: Adrian F Gombart; Jeffrey Grewal; H Phillip Koeffler
ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha.
Journal of leukocyte biology 2007;81(6):1535-47.
2007: Miyuki Tanaka; Adrian F Gombart; H Phillip Koeffler; Masaaki Shiohara
Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon.
International journal of hematology 2007;85(4):304-11.
2007: Adrian F Gombart; James O'Kelly; Tsuyako Saito; H Phillip Koeffler
Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):552-7.
2006: Adrian F Gombart; Quang T Luong; H Phillip Koeffler
Vitamin D compounds: activity against microbes and cancer.
Anticancer research 2006;26(4A):2531-42.
2006: Kim Theilgaard-Mönch; Lars C Jacobsen; Marianne Jensby Nielsen; Thomas Rasmussen; Lene Udby; Maged Gharib; Peter Arkwright; Adrian F Gombart; Jero Calafat; Søren K Moestrup; Bo T Porse; Niels Borregaard
Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.
Blood 2006;108(1):353-61.
2006: Robert F Wynn; M Sood; Kim Theilgaard-Mönch; C J Jones; Adrian F Gombart; Maged Gharib; H P Koeffler; Niels Borregaard; Peter Arkwright
Intractable diarrhoea of infancy caused by neutrophil specific granule deficiency and cured by stem cell transplantation.
Gut 2006;55(2):292-3.
2005: Adrian F Gombart; Utz Krug; James O'Kelly; Eun An; Vijaya Vegesna; H Phillip Koeffler
Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiency.
Journal of leukocyte biology 2005;78(5):1153-65.
2005: Sigal Gery; Adrian F Gombart; William S Yi; Chloe Koeffler; Wolf-Karsten Hofmann; H Phillip Koeffler
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
Blood 2005;106(8):2827-36.
2005: Ido Paz-Priel; Dong Hong Cai; Dehua Wang; Jeanne Kowalski; Amanda Blackford; Huaitian Liu; Caroline A Heckman; Adrian F Gombart; H Phillip Koeffler; Linda M Boxer; Alan D Friedman
CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.
Molecular cancer research : MCR 2005;3(10):585-96.
2005: Kim Theilgaard-Mönch; Lars C Jacobsen; Thomas Rasmussen; Carsten U Niemann; Lene Udby; Rehannah Borup; Maged Gharib; Peter Arkwright; Adrian F Gombart; Jero Calafat; Bo T Porse; Niels Borregaard
Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils.
Journal of leukocyte biology 2005;78(2):462-70.
2005: Adrian F Gombart; Niels Borregaard; H Phillip Koeffler
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(9):1067-77.
2004: Kunihiro Tsukasaki; Sakae Tanosaki; Sven DeVos; Wolf-Karsten Hofmann; William Wachsman; Adrian F Gombart; Johannes Krebs; Anna Jauch; Claus R Bartram; Kazuhiro Nagai; Masao Tomonaga; Jonathan W Said; H Phillip Koeffler
Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays.
International journal of cancer. Journal international du cancer 2004;109(6):875-81.
2004: Masaaki Shiohara; Adrian F Gombart; Yukio Sekiguchi; Eiko Hidaka; Susumu Ito; Takashi Yamazaki; H Phillip Koeffler; Atsushi Komiyama
Phenotypic and functional alterations of peripheral blood monocytes in neutrophil-specific granule deficiency.
Journal of leukocyte biology 2004;75(2):190-7.
2004: Sigal Gery; Adrian F Gombart; Yuen K Fung; H Phillip Koeffler
C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.
Blood 2004;103(3):828-35.
2003: Sigal Tavor; Dorothy J Park; Sigal Gery; Peter T Vuong; Adrian F Gombart; H Phillip Koeffler
Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation.
The Journal of biological chemistry 2003;278(52):52651-9.
2003: Adrian F Gombart; Scott H Kwok; Karen L Anderson; Yuji Yamaguchi; Bruce E Torbett; H Phillip Koeffler
Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.
Blood 2003;101(8):3265-73.
2003: Hiroya Asou; Adrian F Gombart; Seisho Takeuchi; Hideo Tanaka; Maki Tanioka; Hirotaka Matsui; Akiro Kimura; Toshiya Inaba; H Phillip Koeffler
Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene.
Genes, chromosomes & cancer 2003;36(2):167-74.
2002: Sigal Tavor; Peter T Vuong; Dorothy J Park; Adrian F Gombart; Arthur H Cohen; H Phillip Koeffler
Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice.
Blood 2002;99(5):1794-801.
2002: Adrian F Gombart; Wolf-Karsten Hofmann; Seiji Kawano; Seisho Takeuchi; Utz Krug; Scott H Kwok; Renee J Larsen; Hiroya Asou; Carl W Miller; Dieter Hoelzer; H Phillip Koeffler
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.
Blood 2002;99(4):1332-40.
2002: Adrian F Gombart; H Phillip Koeffler
Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon).
Current opinion in hematology 2002;9(1):36-42.
2001: Hiroshi Kawabata; RS Germain; Takayuki Ikezoe; Xiangjun Tong; E M Green; Adrian F Gombart; H Phillip Koeffler
Regulation of expression of murine transferrin receptor 2.
Blood 2001;98(6):1949-54.
2001: Adrian F Gombart; Masaaki Shiohara; Scott H Kwok; K Agematsu; A Komiyama; H Phillip Koeffler
Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon.
Blood 2001;97(9):2561-7.
2001: S F Rashid; joanne mountford; Adrian F Gombart; Moray J Campbell
1alpha,25-dihydroxyvitamin D(3) displays divergent growth effects in both normal and malignant cells.
Steroids 2001;66(3-5):433-40.
2000: Moray J Campbell; Adrian F Gombart; Scott H Kwok; S Park; H Phillip Koeffler
The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression.
Oncogene 2000;19(44):5091-7.
1999: S Kawano; Carl W Miller; Adrian F Gombart; C R Bartram; Y Matsuo; Hiroya Asou; Akiko Sakashita; Jonathan Said; E Tatsumi; H Phillip Koeffler
Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.
Blood 1999;94(3):1113-20.
1999: Hiroshi Kawabata; R Yang; Toshiyasu Hirama; Peter T Vuong; Seiji Kawano; Adrian F Gombart; H Phillip Koeffler
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family.
The Journal of biological chemistry 1999;274(30):20826-32.
1999: Dorothy J Park; Alexey Chumakov; Peter T Vuong; Doris Y Chih; Adrian F Gombart; W H Miller; H Phillip Koeffler
CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment.
The Journal of clinical investigation 1999;103(10):1399-408.
1999: W Verbeek; Adrian F Gombart; Alexey Chumakov; C Müller; Alan D Friedman; H Phillip Koeffler
C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.
Blood 1999;93(10):3327-37.
1998: Elizabeth A Williamson; H N Xu; Adrian F Gombart; W Verbeek; Alexey Chumakov; Alan D Friedman; H Phillip Koeffler
Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein epsilon.
The Journal of biological chemistry 1998;273(24):14796-804.
1997: Roberta Morosetti; Dorothy J Park; Alexey Chumakov; I Grillier; Masaaki Shiohara; Adrian F Gombart; Tsuyoshi Nakamaki; K Weinberg; H Phillip Koeffler
A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation.
Blood 1997;90(7):2591-600.
1997: Adrian F Gombart; R Yang; M J Campbell; J D Berman; H P Koeffler
Inhibition of growth of human leukemia cell lines by retrovirally expressed wild-type p16INK4A.
Leukemia 1997;11(10):1673-80.
1997: Masaaki Shiohara; Adrian F Gombart; J D Berman; K Koike; A Komiyama; H Phillip Koeffler
Cytostatic effect of TNFalpha on cancer cells is independent of p21WAF1.
Oncogene 1997;15(13):1605-9.
1997: W Verbeek; Adrian F Gombart; Masaaki Shiohara; M Campbell; H Phillip Koeffler
Vitamin D receptor: no evidence for allele-specific mRNA stability in cells which are heterozygous for the Taq I restriction enzyme polymorphism.
Biochemical and biophysical research communications 1997;238(1):77-80.
1996: Masaaki Shiohara; K Spirin; Jonathan W Said; Adrian F Gombart; Tsuyoshi Nakamaki; Seisho Takeuchi; Y Hatta; Roberta Morosetti; Taizo Tasaka; Taku Seriu; C Bartram; Carl W Miller; Masao Tomonaga; H Phillip Koeffler
Alterations of the cyclin-dependent kinase inhibitor p19 (INK4D) is rare in hematopoietic malignancies.
Leukemia 1996;10(12):1897-900.
1996: A Ishiguro; K S Spirin; Masaaki Shiohara; A Tobler; Adrian F Gombart; Mark Israel; J D Norton; H Phillip Koeffler
Id2 expression increases with differentiation of human myeloid cells.
Blood 1996;87(12):5225-31.
1996: Masaaki Shiohara; M Akashi; Adrian F Gombart; Rong Yang; H Phillip Koeffler
Tumor necrosis factor alpha: posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells.
Journal of cellular physiology 1996;166(3):568-76.
1995: R Morosétti; N Kawamata; Adrian F Gombart; Carl W Miller; Y Hatta; T Hirama; Jonathan W Said; Masao Tomonaga; H Phillip Koeffler
Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma.
Blood 1995;86(5):1924-30.
1995: Adrian F Gombart; Roberta Morosetti; Carl W Miller; Jonathan W Said; H Phillip Koeffler
Deletions of the cyclin-dependent kinase inhibitor genes p16INK4A and p15INK4B in non-Hodgkin's lymphomas.
Blood 1995;86(4):1534-9.
1995: Rong Yang; Adrian F Gombart; M Serrano; H Phillip Koeffler
Mutational effects on the p16INK4a tumor suppressor protein.
Cancer research 1995;55(12):2503-6.