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Candelaria Gomez-Manzano

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Marta M Alonso; Candelaria Gomez-Manzano; Hong Jiang; Juan Fueyo
Targeting brain tumor stem cells with oncolytic adenoviruses.
Hong Jiang; Erin J White; Christian I Ríos-Vicil; Jing Xu; Candelaria Gomez-Manzano; Juan Fueyo
Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity.
Juan Fueyo; Candelaria Gomez-Manzano; W K Alfred Yung
Advances in translational research in neuro-oncology.

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All Publications

2012: Marta M Alonso; Candelaria Gomez-Manzano; Hong Jiang; Juan Fueyo
Targeting brain tumor stem cells with oncolytic adenoviruses.
Methods in molecular biology (Clifton, N.J.) 2012;797():111-25.
2011: Hong Jiang; Erin J White; Christian I Ríos-Vicil; Jing Xu; Candelaria Gomez-Manzano; Juan Fueyo
Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity.
Journal of virology 2011;85(10):4720-9.
2011: Juan Fueyo; Candelaria Gomez-Manzano; W K Alfred Yung
Advances in translational research in neuro-oncology.
Archives of neurology 2011;68(3):303-8.
2011: Marta M Alonso; Ander Aramburu; Eva Bandrés; Nahir Cortes-Santiago; Ricardo Diez-Valle; Juan Fueyo; Jesús García-Foncillas; Miguel A Idoate; Patricia Jauregi; Frederick F Lang; Dan Liu; Lorea Manterola; María D Odero; Angel Rubio; Nicolás Sampron; Sonia Tejada-Solís; Leire Urquiza; Carmen Vicente; Adolfo Lopez de Munain; Candelaria Gomez-Manzano
Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas.
PloS one 2011;6(11):e26740.
2011: Khalid A Mohamedali; Latha Ramdas; Sophia Ran; Lawrence H Cheung; Candelaria Gomez-Manzano; Walter N Hittelman; Sehoon Kim; Philip E Thorpe; Johannes Waltenberger; Jing Xu; Wei Zhang; Michael G Rosenblum
Cytotoxicity of VEGF(121)/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2.
BMC cancer 2011;11():358.
2010: Dan Liu; Vanesa Martin; Juan Fueyo; Ok-Hee Lee; Jing Xu; Nahir Cortes-Santiago; Marta M Alonso; Kenneth Aldape; Latif Shooshtari Nasrin; Candelaria Gomez-Manzano
Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype.
Oncotarget 2010;1(8):700-9.
2010: Hong Jiang; Vanesa Martin; Marta Alonso; Candelaria Gomez-Manzano; Juan Fueyo
RB-E2F1: molecular rheostat for autophagy and apoptosis.
Autophagy 2010;6(8):1216-7.
2010: Hong Jiang; Vanesa Martin; Candelaria Gomez-Manzano; David G Johnson; Marta Alonso; Erin White; Jing Xu; Timothy J McDonnell; Naoki Shinojima; Juan Fueyo
The RB-E2F1 pathway regulates autophagy.
Cancer research 2010;70(20):7882-93.
2010: Candelaria Gomez-Manzano; Juan Fueyo
Oncolytic adenoviruses for the treatment of brain tumors.
Current opinion in molecular therapeutics 2010;12(5):530-7.
2010: Jennifer Dembinski; Erika L Spaeth; Juan Fueyo; Candelaria Gomez-Manzano; Matus Studeny; Michael Andreeff; Frank C Marini
Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells.
Cancer gene therapy 2010;17(4):289-97.
2009: Hong Jiang; Candelaria Gomez-Manzano; Frederick F Lang; Ramon Alemany; Juan Fueyo
Oncolytic adenovirus: preclinical and clinical studies in patients with human malignant gliomas.
Current gene therapy 2009;9(5):422-7.
2009: V Martin; Jing Xu; S K Pabbisetty; Marta M Alonso; D Liu; Ok-Hee Lee; Joy Gumin; Krishna P Bhat; Howard Colman; Frederick F Lang; Juan Fueyo; Candelaria Gomez-Manzano
Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters.
Oncogene 2009;28(24):2358-63.
2009: Yuji Piao; Hong Jiang; Ramon Alemany; Victor Krasnykh; Frank C Marini; J Xu; Marta M Alonso; Charles A Conrad; Kenneth Aldape; Candelaria Gomez-Manzano; Juan Fueyo
Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity.
Cancer gene therapy 2009;16(3):256-65.
2009: Hong Jiang; Erin J White; Charles Conrad; Candelaria Gomez-Manzano; Juan Fueyo
Autophagy pathways in glioblastoma.
Methods in enzymology 2009;453():273-86.
2009: Vanesa Martin; Dan Liu; Candelaria Gomez-Manzano
Encountering and advancing through antiangiogenesis therapy for gliomas.
Current pharmaceutical design 2009;15(4):353-64.
2008: V Martin; D Liu; Juan Fueyo; Candelaria Gomez-Manzano
Tie2: a journey from normal angiogenesis to cancer and beyond.
Histology and histopathology 2008;23(6):773-80.
2008: Marta M Alonso; Ramon Alemany; Juan Fueyo; Candelaria Gomez-Manzano
E2F1 in gliomas: a paradigm of oncogene addiction.
Cancer letters 2008;263(2):157-63.
2008: Candelaria Gomez-Manzano; Marta Alonso; Hong Jiang; Juan Fueyo
Interspecies adenovirus fiber shows "evolutionary" advantage for oncolytic therapy of gliomas.
Cancer biology & therapy 2008;7(5):794-6.
2008: Marta M Alonso; Hong Jiang; Tomohisa Yokoyama; Jing Xu; Nebiyou Bekele; Frederick F Lang; Seiji Kondo; Candelaria Gomez-Manzano; Juan Fueyo
Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):487-93.
2008: Ok-Hee Lee; Jing Xu; Juan Fueyo; Marta M Alonso; D Liu; V Martin; Hong Jiang; Yuji Piao; Ta-Jen Liu; Candelaria Gomez-Manzano
Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1 alpha levels in gliomas.
Oncogene 2008;27(9):1310-4.
2008: Hong Jiang; Erin J White; Candelaria Gomez-Manzano; Juan Fueyo
Adenovirus's last trick: you say lysis, we say autophagy.
Autophagy 2008;4(1):118-20.
2007: Marta M Alonso; Candelaria Gomez-Manzano; B Nebiyou Bekele; W K Alfred Yung; Juan Fueyo
Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter.
Cancer research 2007;67(24):11499-504.
2007: Hong Jiang; Candelaria Gomez-Manzano; Hiroshi Aoki; Marta M Alonso; Seiji Kondo; Frank McCormick; Jing Xu; Yasuko Kondo; B Nebiyou Bekele; Howard Colman; Frederick F Lang; Juan Fueyo
Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death.
Journal of the National Cancer Institute 2007;99(18):1410-4.
2007: Marta M Alonso; Manel Cascallo; Candelaria Gomez-Manzano; Hong Jiang; B Nebiyou Bekele; Anna Perez-Gimenez; Frederick F Lang; Yuji Piao; Ramon Alemany; Juan Fueyo
ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo.
Cancer research 2007;67(17):8255-63.
2007: Marta M Alonso; Candelaria Gomez-Manzano; Hong Jiang; Nebiyou Bekele; Yuji Piao; W K Alfred Yung; Ramon Alemany; Juan Fueyo
Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo.
Cancer gene therapy 2007;14(8):756-61.
2007: Melissa V Olson; David G Johnson; Hong Jiang; Jing Xu; Marta M Alonso; Kenneth Aldape; Gregory N Fuller; B Nebiyou Bekele; W K Alfred Yung; Candelaria Gomez-Manzano; Juan Fueyo
Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors.
Cancer research 2007;67(9):4005-9.
2006: Ok-Hee Lee; Jing Xu; Juan Fueyo; Gregory N Fuller; Kenneth Aldape; Marta M Alonso; Yuji Piao; Ta-Jen Liu; Frederick F Lang; B Nebiyou Bekele; Candelaria Gomez-Manzano
Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix.
Molecular cancer research : MCR 2006;4(12):915-26.
2006: Hong Jiang; Melissa V Olson; Diana R Medrano; Ok-Hee Lee; Jing Xu; Yuji Piao; Marta M Alonso; Candelaria Gomez-Manzano; Mien-Chie Hung; W K Alfred Yung; Juan Fueyo
A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2603-5.
2006: Hong Jiang; Marta M Alonso; Candelaria Gomez-Manzano; Yuji Piao; Juan Fueyo
Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas.
Expert review of anticancer therapy 2006;6(11):1585-92.
2006: Ok-Hee Lee; Juan Fueyo; Jing Xu; W K Alfred Yung; Michael G Lemoine; Frederick F Lang; B Nebiyou Bekele; Xian Zhou; Marta A Alonso; Kenneth Aldape; Gregory N Fuller; Candelaria Gomez-Manzano
Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth.
Neoplasia (New York, N.Y.) 2006;8(5):419-28.
2006: Hong Jiang; Frank McCormick; Frederick F Lang; Candelaria Gomez-Manzano; Juan Fueyo
Oncolytic adenoviruses as antiglioma agents.
Expert review of anticancer therapy 2006;6(5):697-708.
2006: Marta M Alonso; Juan Fueyo; W K Alfred Yung; Candelaria Gomez-Manzano
E2F1 and telomerase: alliance in the dark side.
Cell cycle (Georgetown, Tex.) 2006;5(9):930-5.
2006: Candelaria Gomez-Manzano; Marta M Alonso; W K Alfred Yung; Frank McCormick; David T Curiel; Frederick F Lang; Hong Jiang; B Nebiyou Bekele; Xian Zhou; Ramon Alemany; Juan Fueyo
Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):556-62.
2005: Marta M Alonso; Juan Fueyo; Jerry W Shay; Kenneth Aldape; Hong Jiang; Ok-Hee Lee; David G Johnson; Jing Xu; Yasuko Kondo; Takao Kanzawa; Satoru Kyo; B Nebiyou Bekele; Xian Zhou; Janice Nigro; J Matthew McDonald; W K Alfred Yung; Candelaria Gomez-Manzano
Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance.
Journal of the National Cancer Institute 2005;97(21):1589-600.
2005: Hong Jiang; Ramon Alemany; Candelaria Gomez-Manzano; Diana R Medrano; Michael G Lemoine; Melissa V Olson; Marta M Alonso; Ok-Hee Lee; Charles C Conrad; W K Alfred Yung; Juan Fueyo
Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses.
Neoplasia (New York, N.Y.) 2005;7(8):723-9.
2005: Charles Conrad; Ryan Miller; Yongjie Ji; Candelaria Gomez-Manzano; Suman Bharara; John S McMurray; Frederick F Lang; Franklin Wong; Raymond Sawaya; W K Alfred Yung; Juan Fueyo
Delta24-hyCD adenovirus suppresses glioma growth in vivo by combining oncolysis and chemosensitization.
Cancer gene therapy 2005;12(3):284-94.
2005: Hong Jiang; Candelaria Gomez-Manzano; Ramon Alemany; Diana R Medrano; Marta Alonso; B Nebiyou Bekele; E Lin; Charles C Conrad; W K Alfred Yung; Juan Fueyo
Comparative effect of oncolytic adenoviruses with E1A-55 kDa or E1B-55 kDa deletions in malignant gliomas.
Neoplasia (New York, N.Y.) 2005;7(1):48-56.
2004: Robert A Stolarek; Candelaria Gomez-Manzano; Hong Jiang; Gary Suttle; Michael G Lemoine; Juan Fueyo
Robust infectivity and replication of Delta-24 adenovirus induce cell death in human medulloblastoma.
Cancer gene therapy 2004;11(11):713-20.
2004: Candelaria Gomez-Manzano; W K Alfred Yung; Ramon Alemany; Juan Fueyo
Genetically modified adenoviruses against gliomas: from bench to bedside.
Neurology 2004;63(3):418-26.
2004: Candelaria Gomez-Manzano; Cristina Balague; Ramon Alemany; Michael G Lemoine; Paraskevi G Mitlianga; Hong Jiang; Asadullah Khan; Marta Alonso; Frederick F Lang; Charles A Conrad; Ta-Jen Liu; B Nebiyou Bekele; W K Alfred Yung; Juan Fueyo
A novel E1A-E1B mutant adenovirus induces glioma regression in vivo.
Oncogene 2004;23(10):1821-8.
2003: Ho-Young Lee; Harish Srinivas; Dianren Xia; Yiling Lu; Robert Superty; Ruth Lapushin; Candelaria Gomez-Manzano; Anna Maria Gal; Garrett L Walsh; Thomas Force; Kohjiro Ueki; Gordon B Mills; Jonathan M Kurie
Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
The Journal of biological chemistry 2003;278(26):23630-8.
2003: Juan Fueyo; Ramon Alemany; Candelaria Gomez-Manzano; Gregory N Fuller; Asadullah Khan; Charles A Conrad; Ta-Jen Liu; Hong Jiang; Michael G Lemoine; Kaori Suzuki; Raymond Sawaya; David T Curiel; W K Alfred Yung; Frederick F Lang
Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway.
Journal of the National Cancer Institute 2003;95(9):652-60.
2003: Hong Jiang; Charles Conrad; Juan Fueyo; Candelaria Gomez-Manzano; Ta-Jen Liu
Oncolytic adenoviruses for malignant glioma therapy.
Frontiers in bioscience : a journal and virtual library 2003;8():d577-88.
2003: Candelaria Gomez-Manzano; Juan Fueyo; Hong Jiang; Tricia L Glass; Ho-Young Lee; Min Hu; Juinn-Lin Liu; Sushma L Jasti; Ta-Jen Liu; Charles A Conrad; W K Alfred Yung
Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis.
Annals of neurology 2003;53(1):109-17.
2002: Paraskevi G Mitlianga; Candelaria Gomez-Manzano; Athanassios P Kyritsis; Juan Fueyo
Overexpression of E2F-1 leads to bax-independent cell death in human glioma cells.
International journal of oncology 2002;21(5):1015-20.
2001: Candelaria Gomez-Manzano; Paraskevi G Mitlianga; Juan Fueyo; Ho-Young Lee; Min Hu; Kevin B Spurgers; Tricia L Glass; Dimpy Koul; Ta-Jen Liu; Timothy J McDonnell; W K Alfred Yung
Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2.
Cancer research 2001;61(18):6693-7.
2001: Candelaria Gomez-Manzano; Michael G Lemoine; Min Hu; J He; Paraskevi G Mitlianga; Ta-Jen Liu; Alfred W K Yung; Juan Fueyo; Morris D Groves
Adenovirally-mediated transfer of E2F-1 potentiates chemosensitivity of human glioma cells to temozolomide and BCNU.
International journal of oncology 2001;19(2):359-65.
2001: Seock-Ah Im; J S Kim; Candelaria Gomez-Manzano; J Fueyo; T J Liu; M S Cho; Chu-Myong Seong; Shi Nae Lee; Y K Hong; W K Yung
Inhibition of breast cancer growth in vivo by antiangiogenesis gene therapy with adenovirus-mediated antisense-VEGF.
British journal of cancer 2001;84(9):1252-7.
2001: Juan Fueyo; Candelaria Gomez-Manzano; Ta-Jen Liu; W K Alfred Yung
Delivery of cell cycle genes to block astrocytoma growth.
Journal of neuro-oncology 2001;51(3):277-87.
2001: Paraskevi G Mitlianga; Athanassios P Kyritsis; Candelaria Gomez-Manzano; Michael G Lemoine; Min Hu; Ta-Jen Liu; W K Alfred Yung; Juan Fueyo
Co-expression of E2F-2 enhances the p53 anti-cancer effect in human glioma cells.
International journal of oncology 2001;18(2):343-7.
2000: Juan Fueyo; Candelaria Gomez-Manzano; Ramon Alemany; P S Lee; Timothy J McDonnell; Paraskevi G Mitlianga; Yue-Xi Shi; Victor Levin; W K Alfred Yung; Athanassios P Kyritsis
A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.
Oncogene 2000;19(1):2-12.
1999: Ramon Alemany; Candelaria Gomez-Manzano; Cristina Balagué; W K Alfred Yung; David T Curiel; Athanassios P Kyritsis; Juan Fueyo
Gene therapy for gliomas: molecular targets, adenoviral vectors, and oncolytic adenoviruses.
Experimental cell research 1999;252(1):1-12.
1999: Juan Fueyo; Candelaria Gomez-Manzano; W K Alfred Yung; Athanassios P Kyritsis
Targeting in gene therapy for gliomas.
Archives of neurology 1999;56(4):445-8.
1999: Seock-Ah Im; Candelaria Gomez-Manzano; Juan Fueyo; Ta-Jen Liu; Li Dao Ke; Jang-Seong Kim; Ho-Young Lee; PA Steck; Athanassios P Kyritsis; W K Alfred Yung
Antiangiogenesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo.
Cancer research 1999;59(4):895-900.
1999: Candelaria Gomez-Manzano; Juan Fueyo; F Alameda; Athanassios P Kyritsis; W K Alfred Yung
Gene therapy for gliomas: p53 and E2F-1 proteins and the target of apoptosis.
International journal of molecular medicine 1999;3(1):81-5.
1998: Juan Fueyo; Candelaria Gomez-Manzano; W K Alfred Yung; Athanassios P Kyritsis
The functional role of tumor suppressor genes in gliomas: clues for future therapeutic strategies.
Neurology 1998;51(5):1250-5.
1998: Juan Fueyo; Candelaria Gomez-Manzano; W K Alfred Yung; Ta-Jen Liu; Ramon Alemany; Timothy J McDonnell; X Shi; Jasti Sambasiva Rao; Victor Levin; Athanassios P Kyritsis
Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo.
Nature medicine 1998;4(6):685-90.
1998: Juan Fueyo; Candelaria Gomez-Manzano; W K Alfred Yung; Ta-Jen Liu; Ramon Alemany; Janet M Bruner; Chintala Shravan; Jasti Sambasiva Rao; Victor Levin; Athanassios P Kyritsis
Suppression of human glioma growth by adenovirus-mediated Rb gene transfer.
Neurology 1998;50(5):1307-15.
1998: Juan Fueyo; Candelaria Gomez-Manzano; Vinay K Puduvalli; P Martin-Duque; Roman Perez-Soler; Victor Levin; W K Alfred Yung; Athanassios P Kyritsis
Adenovirus-mediated p16 transfer to glioma cells induces G1 arrest and protects from paclitaxel and topotecan: implications for therapy.
International journal of oncology 1998;12(3):665-9.
1997: Chintala Shravan; Juan Fueyo; Candelaria Gomez-Manzano; B Venkaiah; R Bjerkvig; W K Alfred Yung; Raymond Sawaya; Athanassios P Kyritsis; Jasti Sambasiva Rao
Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro.
Oncogene 1997;15(17):2049-57.
1997: Candelaria Gomez-Manzano; Juan Fueyo; Athanassios P Kyritsis; Timothy J McDonnell; PA Steck; Victor Levin; W K Alfred Yung
Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.
Journal of the National Cancer Institute 1997;89(14):1036-44.
1996: Juan Fueyo; Candelaria Gomez-Manzano; Janet M Bruner; Y Saito; B Zhang; W Zhang; Victor Levin; W K Alfred Yung; Athanassios P Kyritsis
Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas.
Oncogene 1996;13(8):1615-9.
1996: Candelaria Gomez-Manzano; Juan Fueyo; Athanassios P Kyritsis; PA Steck; Jack A Roth; Timothy J McDonnell; KD Steck; Victor Levin; W K Alfred Yung
Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis.
Cancer research 1996;56(4):694-9.
1996: Juan Fueyo; Candelaria Gomez-Manzano; W K Alfred Yung; Gary L Clayman; Ta-Jen Liu; Janet Bruner; Victor Levin; Athanassios P Kyritsis
Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells.
Oncogene 1996;12(1):103-10.
1995: Juan Fueyo; Candelaria Gomez-Manzano; W K Alfred Yung; W Zhang; P S Lee; S Majumder; M Perhouse; Victor Levin; Athanassios P Kyritsis
A frequent polymorphism in exon 1 of the p16/CDKN2 gene.
Molecular and cellular probes 1995;9(6):465-6.
1993: Juan Fueyo; Candelaria Gomez-Manzano; J Pascual; A Pou
Paraneoplastic syndromes.
Neurology 1993;43(1):236.