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Paulino Gómez-Puertas

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Physiology

Phenomena

Protein Binding

Living Beings

Escherichia coli

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Publications

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Beatriz Puisac; Antonia Ribes; María Esperanza Teresa-Rodrigo; María Arnedo; Gloria Bueno; María Concepción Gil-Rodríguez; Paulino Gómez-Puertas; Celia Pérez-Cerdá; Angeles Pié; Juan Pié
Analysis of aberrant splicing and nonsense-mediated decay of the stop codon mutations c.109G>T and c.504_505delCT in 7 patients with HMG-CoA lyase deficiency.
MJ Perteguer; Carmen Cañavate; Fracehuli Dagger; Teresa Gárate; Paulino Gómez-Puertas; Elizabeth Valdivieso
Ddi1-like protein from Leishmania major is an active aspartyl proteinase.
Fernando Martín-García; Paulino Gómez-Puertas; Iñigo Marcos-Alcalde; Jesús I Mendieta-Moreno; Jesús Mendieta
Simulation of catalytic water activation in mitochondrial F1-ATPase using a hybrid quantum mechanics/molecular mechanics approach: an alternative role for β-Glu 188.

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All Publications

2013: Beatriz Puisac; Antonia Ribes; María Esperanza Teresa-Rodrigo; María Arnedo; Gloria Bueno; María Concepción Gil-Rodríguez; Paulino Gómez-Puertas; Celia Pérez-Cerdá; Angeles Pié; Juan Pié
Analysis of aberrant splicing and nonsense-mediated decay of the stop codon mutations c.109G>T and c.504_505delCT in 7 patients with HMG-CoA lyase deficiency.
Molecular genetics and metabolism 2013;108(4):232-40.
2013: MJ Perteguer; Carmen Cañavate; Fracehuli Dagger; Teresa Gárate; Paulino Gómez-Puertas; Elizabeth Valdivieso
Ddi1-like protein from Leishmania major is an active aspartyl proteinase.
Cell stress & chaperones 2013;18(2):171-81.
2013: Fernando Martín-García; Paulino Gómez-Puertas; Iñigo Marcos-Alcalde; Jesús I Mendieta-Moreno; Jesús Mendieta
Simulation of catalytic water activation in mitochondrial F1-ATPase using a hybrid quantum mechanics/molecular mechanics approach: an alternative role for β-Glu 188.
Biochemistry 2013;52(5):959-66.
2012: María Arnedo; César H Casale; Núria Casals; María C Gil-Rodríguez; Paulino Gómez-Puertas; Fausto G Hegardt; Eduardo López-Viñas; Sebastián Menao; Beatriz Puisac; María E Teresa-Rodrigo; Juan Pié
Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol.
Journal of lipid research 2012;53(10):2046-56.
2012: Mónica González-Magaldi; Leonor Kremer; Eduardo López-Viñas; Raúl Postigo; Miguel Rodríguez-Pulido; María F Rosas; David Andreu; Beatriz G de la Torre; Paulino Gómez-Puertas; Yuri A Vieira; Francisco Sobrino
Mutations that hamper dimerization of foot-and-mouth disease virus 3A protein are detrimental for infectivity.
Journal of virology 2012;86(20):11013-23.
2012: Rubén Ahijado-Guzmán; Ramón A Alvarez-Puebla; Paulino Gómez-Puertas; Germán Rivas; Luis M Liz-Marzán
Surface-Enhanced Raman scattering-based detection of the interactions between the essential cell division FtsZ protein and bacterial membrane elements.
ACS nano 2012;6(8):7514-20.
2012: Fernando Martín-García; Jesús Mendieta; Jesús Ignacio Mendieta-Moreno; Jesús Mingorance; Estefanía Salvarelli; Miguel Vicente; Paulino Gómez-Puertas
Molecular dynamics simulation of GTPase activity in polymers of the cell division protein FtsZ.
FEBS letters 2012;586(8):1236-9.
2012: Beatriz Puisac; Feliciano J Ramos; Mónica Ramos; María Esperanza Teresa-Rodrigo; Jan-Jaap Wesselink; María Arnedo; Núria Casals; Juan Carlos de Karam; María Concepción Gil-Rodríguez; Ignacio Giménez; Paulino Gómez-Puertas; Fausto G Hegardt; Sebastián Menao; Angeles Pié; Juan Pié
Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.
Molecular biology reports 2012;39(4):4777-85.
2012: Fernando Martín-García; Jesús Mendieta; Jesús Ignacio Mendieta-Moreno; Paulino Gómez-Puertas
Molecular dynamics analysis of conformational change of paramyxovirus F protein during the initial steps of membrane fusion.
Biochemical and biophysical research communications 2012;420(1):42-7.
2011: Rute Gonçalves Matos; Ana Barbas; Paulino Gómez-Puertas; Cecília M Arraiano
Swapping the domains of exoribonucleases RNase II and RNase R: conferring upon RNase II the ability to degrade ds RNA.
Proteins 2011;79(6):1853-67.
2011: Javier Oroz; Alejandro Valbuena; Andrés Manuel Vera; Jesús Mendieta; Paulino Gómez-Puertas; Mariano Carrión-Vázquez
Nanomechanics of the cadherin ectodomain: "canalization" by Ca2+ binding results in a new mechanical element.
The Journal of biological chemistry 2011;286(11):9405-18.
2011: Carolina Hurtado; María J Bustos; Aitor G Granja; Patricia de León; Prado Sabina; Eduardo López-Viñas; Paulino Gómez-Puertas; Yolanda Revilla; Angel L Carrascosa
The African swine fever virus lectin EP153R modulates the surface membrane expression of MHC class I antigens.
Archives of virology 2011;156(2):219-34.
2011: Elena López; Isabel López; Jesús Mendieta; Paulino Gómez-Puertas; Jan-Jaap Wesselink; Sarbelio Rodríguez Muñoz
Technical phosphoproteomic and bioinformatic tools useful in cancer research.
Journal of clinical bioinformatics 2011;1():26.
2010: Jesús Mingorance; Germán Rivas; Marisela Vélez; Paulino Gómez-Puertas; Miguel Vicente
Strong FtsZ is with the force: mechanisms to constrict bacteria.
Trends in microbiology 2010;18(8):348-56.
2010: Margarita Magro; David Andreu; Paulino Gómez-Puertas; José A Melero; Concepción Palomo
Neutralization of human respiratory syncytial virus infectivity by antibodies and low-molecular-weight compounds targeted against the fusion glycoprotein.
Journal of virology 2010;84(16):7970-82.
2010: Valeria Romanelli; Alberta Belinchón; Sara Benito-Sanz; Victor Martinez-Glez; Ricardo Gracia Bouthelier; Karen E Heath; Angel Campos-Barros; Sixto García-Miñaur; Luís Fernandez; Heloisa Meneses; Juan Pedro López-Siguero; Encarna Guillén-Navarro; Paulino Gómez-Puertas; Jan-Jaap Wesselink; Graciela Mercado; Victoria Esteban-Marfil; Rebeca Palomo; Rocío Mena; Aurora Sánchez; Miguel Del Campo; Pablo Lapunzina
CDKN1C (p57(Kip2)) analysis in Beckwith-Wiedemann syndrome (BWS) patients: Genotype-phenotype correlations, novel mutations, and polymorphisms.
American journal of medical genetics. Part A 2010;152A(6):1390-7.
2010: Juan Pié; María Concepción Gil-Rodríguez; Milagros Ciero; Eduardo López-Viñas; María Pilar Ribate; María Arnedo; Matthew A Deardorff; Beatriz Puisac; Jesús Legarreta; Juan Carlos de Karam; Encarnación Rubio; Inés Bueno; Antonio Baldellou; M Teresa Calvo; Nuria Casals; José Luis Olivares; Ana Losada; Fausto G Hegardt; Ian D Krantz; Paulino Gómez-Puertas; Feliciano J Ramos
Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome.
American journal of medical genetics. Part A 2010;152A(4):924-9.
2009: Jesús Mendieta; Ana Isabel Rico; Eduardo López-Viñas; Miguel Vicente; Jesús Mingorance; Paulino Gómez-Puertas
Structural and functional model for ionic (K(+)/Na(+)) and pH dependence of GTPase activity and polymerization of FtsZ, the prokaryotic ortholog of tubulin.
Journal of molecular biology 2009;390(1):17-25.
2009: Paula Mera; Assia Bentebibel; Eduardo López-Viñas; Antonio G Cordente; Chandrashekaran Gurunathan; David Sebastián; Irene Vázquez; Laura Herrero; Xavier Ariza; Paulino Gómez-Puertas; Guillermina Asins; Dolors Serra; Jordi García; Fausto G Hegardt
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight.
Biochemical pharmacology 2009;77(6):1084-95.
2009: Sebastián Menao; Eduardo López-Viñas; Cecilia Mir; Beatriz Puisac; Esther Gratacós; María Arnedo; Patricia Carrasco; Susana Moreno; Mónica Ramos; María Concepción Gil; Angeles Pié; Antonia Ribes; Celia Pérez-Cerda; Magdalena Ugarte; Peter T Clayton; Stanley H Korman; Dolors Serra; Guillermina Asins; Feliciano J Ramos; Paulino Gómez-Puertas; Fausto G Hegardt; Núria Casals; Juan Pié
Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria.
Human mutation 2009;30(3):E520-9.
2008: Jorge Cuéllar; Jaime Martín-Benito; Sjors H W Scheres; Rui Sousa; Fernando Moro; Eduardo López-Viñas; Paulino Gómez-Puertas; Arturo Muga; José L Carrascosa; José M Valpuesta
The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.
Nature structural & molecular biology 2008;15(8):858-64.
2008: Ana Asenjo; Jesús Mendieta; Paulino Gómez-Puertas; Nieves Villanueva
Residues in human respiratory syncytial virus P protein that are essential for its activity on RNA viral synthesis.
Virus research 2008;132(1-2):160-73.
2008: Sílvia Atrian; Eduardo López-Viñas; Paulino Gómez-Puertas; Amparo Chabás; Lluïsa Vilageliu; Daniel Grinberg
An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions - relevance for Gaucher disease.
Proteins 2008;70(3):882-91.
2007: Juan Pié; Eduardo López-Viñas; Beatriz Puisac; Sebastián Menao; Angeles Pié; Cesar Casale; Feliciano J Ramos; Fausto G Hegardt; Paulino Gómez-Puertas; Núria Casals
Molecular genetics of HMG-CoA lyase deficiency.
Molecular genetics and metabolism 2007;92(3):198-209.
2007: Eduardo López-Viñas; Assia Bentebibel; Chandrashekaran Gurunathan; Montserrat Morillas; Dolores de Arriaga; Dolors Serra; Guillermina Asins; Fausto G Hegardt; Paulino Gómez-Puertas
Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.
The Journal of biological chemistry 2007;282(25):18212-24.
2007: Patricia Carrasco; Sebastián Menao; Eduardo López-Viñas; Gabriel Santpere; Josep Clotet; Adriana Sierra; Esther Gratacós; Beatriz Puisac; Paulino Gómez-Puertas; Fausto G Hegardt; Juan Pie; Núria Casals
C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity.
Molecular genetics and metabolism 2007;91(2):120-7.
2007: Felipe Cava; Oleg Laptenko; Sergei Borukhov; Zahra Chahlafi; Emilio Blas-Galindo; Paulino Gómez-Puertas; José Berenguer
Control of the respiratory metabolism of Thermus thermophilus by the nitrate respiration conjugative element NCE.
Molecular microbiology 2007;64(3):630-46.
2007: Xabier Agirrezabala; Javier A Velázquez-Muriel; Paulino Gómez-Puertas; Sjors H W Scheres; Jose M Carazo; José L Carrascosa
Quasi-atomic model of bacteriophage t7 procapsid shell: insights into the structure and evolution of a basic fold.
Structure (London, England : 1993) 2007;15(4):461-72.
2007: Jaime Martín-Benito; Juan J Gómez-Reino; Peter C Stirling; Victor F Lundin; Paulino Gómez-Puertas; Jasminka Boskovic; Pablo Chacon; José J Fernández; José Berenguer; Michel R Leroux; José M Valpuesta
Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart.
Structure (London, England : 1993) 2007;15(1):101-10.
2006: Pilar Rodríguez-Pombo; Rosa Navarrete; Begoña Merinero; Paulino Gómez-Puertas; Magdalena Ugarte
Mutational spectrum of maple syrup urine disease in Spain.
Human mutation 2006;27(7):715.
2006: Antonio G Cordente; Eduardo López-Viñas; María Irene Vázquez; Paulino Gómez-Puertas; Guillermina Asins; Dolors Serra; Fausto G Hegardt
Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.
Biochemistry 2006;45(19):6133-41.
2006: Assia Bentebibel; David Sebastián; Laura Herrero; Eduardo López-Viñas; Dolors Serra; Guillermina Asins; Paulino Gómez-Puertas; Fausto G Hegardt
Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.
Biochemistry 2006;45(14):4339-50.
2005: Belén Pérez; Lourdes R Desviat; Paulino Gómez-Puertas; Aurora Martínez; Raymond C Stevens; Magdalena Ugarte
Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients.
Molecular genetics and metabolism 2005;86 Suppl 1():S11-6.
2005: Michael L Tress; David de Juan; Osvaldo Graña; Manuel J Gomez; Paulino Gómez-Puertas; Jose M González; Gonzalo López; Carmen Galvez
Scoring docking models with evolutionary information.
Proteins 2005;60(2):275-80.
2005: Beatriz Puisac; Eduardo López-Viñas; Susana Moreno; Cecilia Mir; Celia Pérez-Cerdá; Sebastián Menao; Dolores Lluch; Angeles Pié; Paulino Gómez-Puertas; Núria Casals; Magdalena Ugarte; Fausto G Hegardt; Juan Pié
Skipping of exon 2 and exons 2 plus 3 of HMG-CoA lyase (HL) gene produces the loss of beta sheets 1 and 2 in the recently proposed (beta-alpha)8 TIM barrel model of HL.
Biophysical chemistry 2005;115(2-3):241-5.
2004: Antonio G Cordente; Eduardo López-Viñas; María Irene Vázquez; Jan H Swiegers; Isak S Pretorius; Paulino Gómez-Puertas; Fausto G Hegardt; Guillermina Asins; Dolors Serra
Redesign of carnitine acetyltransferase specificity by protein engineering.
The Journal of biological chemistry 2004;279(32):33899-908.
2004: Montserrat Morillas; Eduardo López-Viñas; Carmen Galvez; Dolors Serra; Paulino Gómez-Puertas; Fausto G Hegardt; Guillermina Asins
Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.
The Biochemical journal 2004;379(Pt 3):777-84.
2004: Paulino Gómez-Puertas; Jaime Martín-Benito; José L Carrascosa; Keith R Willison; José M Valpuesta
The substrate recognition mechanisms in chaperonins.
Journal of molecular recognition : JMR 2004;17(2):85-94.
2003: Núria Casals; Paulino Gómez-Puertas; Juan Pié; Cecilia Mir; Ramón Roca; Beatriz Puisac; Rosa Aledo; Josep Clotet; Sebastián Menao; Dolors Serra; Guillermina Asins; Jacqueline Till; Alun C Elias-Jones; Juan C Cresto; Nestor A Chamoles; Jose E Abdenur; Ertan Mayatepek; G T N Besley; Carmen Galvez; Fausto G Hegardt
Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.
The Journal of biological chemistry 2003;278(31):29016-23.
2003: Montserrat Morillas; Paulino Gómez-Puertas; Assia Bentebibel; Eva Sellés; Núria Casals; Carmen Galvez; Fausto G Hegardt; Guillermina Asins; Dolors Serra
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.
The Journal of biological chemistry 2003;278(11):9058-63.
2003: Daniele Carettoni; Paulino Gómez-Puertas; Lucía Yim; Jesús Mingorance; Orietta Massidda; Miguel Vicente; Carmen Galvez; Enrico Domenici; Daniela Anderluzzi
Phage-display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA.
Proteins 2003;50(2):192-206.
2002: Jaime Martín-Benito; Jasminka Boskovic; Paulino Gómez-Puertas; José L Carrascosa; C Torrey Simons; Sally A Lewis; Francesca Bartolini; Nicholas J Cowan; José M Valpuesta
Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT.
The EMBO journal 2002;21(23):6377-86.
2002: José M Valpuesta; Jaime Martín-Benito; Paulino Gómez-Puertas; José L Carrascosa; Keith R Willison
Structure and function of a protein folding machine: the eukaryotic cytosolic chaperonin CCT.
FEBS letters 2002;529(1):11-6.
2002: Montserrat Morillas; Paulino Gómez-Puertas; Blanca Rubí; Josep Clotet; Joaquín Ariño; Carmen Galvez; Fausto G Hegardt; Dolors Serra; Guillermina Asins
Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.
The Journal of biological chemistry 2002;277(13):11473-80.
2001: Montserrat Morillas; Paulino Gómez-Puertas; Ramón Roca; Dolors Serra; Guillermina Asins; Carmen Galvez; Fausto G Hegardt
Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.
The Journal of biological chemistry 2001;276(48):45001-8.
2001: Oscar Llorca; Jaime Martín-Benito; Paulino Gómez-Puertas; M Ritco-Vonsovici; Keith R Willison; José L Carrascosa; José M Valpuesta
Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin.
Journal of structural biology 2001;135(2):205-18.
2001: Jesús Mingorance; Sonsoles Rueda; Paulino Gómez-Puertas; Carmen Galvez; Miguel Vicente
Escherichia coli FtsZ polymers contain mostly GTP and have a high nucleotide turnover.
Molecular microbiology 2001;41(1):83-91.