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Thomas Gonda

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Silvia Mori; Massimo Resnati; Rosa Bernardi; Ambra Crippa; Arianna Gabrieli; Thomas J Gonda; Rebecca A Keough; Audrey Laurent; Francesco Blasi
Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor.
Anna L Brown; Grant A Engler; Thomas J Gonda; Chung H Kok; ID Lewis; Michelle Perugini; Timothy J Sadlon; Teresa Sadras; Diana G Salerno; Saumya E Samaraweera; Christopher R Wilkinson; Richard J D'Andrea
The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation.
Cheryl Y Brown; Timothy J Sadlon; Tessa Gargett; Elizabeth Melville; Rui Zhang; Yvette Drabsch; Michael Ling; Craig A Strathdee; Thomas J Gonda; Simon C Barry
Robust, reversible gene knockdown using a single lentiviral short hairpin RNA vector.

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All Publications

2012: Silvia Mori; Massimo Resnati; Rosa Bernardi; Ambra Crippa; Arianna Gabrieli; Thomas J Gonda; Rebecca A Keough; Audrey Laurent; Francesco Blasi
Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor.
PloS one 2012;7(10):e39723.
2012: Anna L Brown; Grant A Engler; Thomas J Gonda; Chung H Kok; ID Lewis; Michelle Perugini; Timothy J Sadlon; Teresa Sadras; Diana G Salerno; Saumya E Samaraweera; Christopher R Wilkinson; Richard J D'Andrea
The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation.
Differentiation; research in biological diversity 2012;83(1):47-59.
2010: Cheryl Y Brown; Timothy J Sadlon; Tessa Gargett; Elizabeth Melville; Rui Zhang; Yvette Drabsch; Michael Ling; Craig A Strathdee; Thomas J Gonda; Simon C Barry
Robust, reversible gene knockdown using a single lentiviral short hairpin RNA vector.
Human gene therapy 2010;21(8):1005-17.
2008: Tomohiro Yamauchi; Rebecca A Keough; Thomas J Gonda; Shunsuke Ishii
Ribosomal stress induces processing of Mybbp1a and its translocation from the nucleolus to the nucleoplasm.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(1):27-39.
2006: Anna L Brown; Christopher R Wilkinson; Scott R Waterman; Chung H Kok; Diana G Salerno; Sonya M Diakiw; Brenton Reynolds; Hamish Scott; Anna Tsykin; Gary F Glonek; Gregory J Goodall; Patty J Solomon; Thomas J Gonda; Richard J D'Andrea
Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modeling.
Journal of leukocyte biology 2006;80(2):433-47.
2006: Jodi K Lutwyche; Rebecca A Keough; Julie Hunter; Leeanne S Coles; Thomas J Gonda
DNA binding-independent transcriptional activation of the vascular endothelial growth factor gene (VEGF) by the Myb oncoprotein.
Biochemical and biophysical research communications 2006;344(4):1300-7.
2004: Jun Tanikawa; Teruaki Nomura; Elizabeth M Macmillan; Toshie Shinagawa; Wanzhu Jin; Kenji Kokura; Daichi Baba; Masahiro Shirakawa; Thomas J Gonda; Shunsuke Ishii
p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A.
The Journal of biological chemistry 2004;279(53):55393-400.
2004: Richard J D'Andrea; Timothy J Sadlon; Thomas J Gonda
Overlapping motifs in the membrane-proximal region of cytokine receptor accessory and signaling subunits.
Cytokine & growth factor reviews 2004;15(2-3):83-5.
2004: Anna L Brown; Michelle Peters; Richard J D'Andrea; Thomas J Gonda
Constitutive mutants of the GM-CSF receptor reveal multiple pathways leading to myeloid cell survival, proliferation, and granulocyte-macrophage differentiation.
Blood 2004;103(2):507-16.
2003: Paul A Bartley; Rebecca A Keough; Jodi K Lutwyche; Thomas J Gonda
Regulation of the gene encoding glutathione S-transferase M1 (GSTM1) by the Myb oncoprotein.
Oncogene 2003;22(48):7570-5.
2003: Rebecca A Keough; Elizabeth M Macmillan; Jodi K Lutwyche; Jennifer M Gardner; Fiona J Tavner; David A Jans; Beric R Henderson; Thomas J Gonda
Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
Experimental cell research 2003;289(1):108-23.
2003: Vernon T Phan; David B Shultz; Bao-Tran H Truong; Timothy J Blake; Anna L Brown; Thomas J Gonda; Michelle M Le Beau; Scott C Kogan
Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.
Molecular and cellular biology 2003;23(13):4573-85.
2002: Timothy J Blake; Brendan J Jenkins; Richard J D'Andrea; Thomas J Gonda
Functional cross-talk between cytokine receptors revealed by activating mutations in the extracellular domain of the beta-subunit of the GM-CSF receptor.
Journal of leukocyte biology 2002;72(6):1246-55.
2001: Jodi K Lutwyche; Rebecca A Keough; T P Hughes; Thomas J Gonda
Mutation screening of the c-MYB negative regulatory domain in acute and chronic myeloid leukaemia.
British journal of haematology 2001;114(3):632-4.
2001: Paul A Bartley; Jodi K Lutwyche; Thomas J Gonda
Identification and validation of candidate Myb target genes.
Blood cells, molecules & diseases 2001;27(2):409-15.
2001: Thomas J Gonda; R Ramsay
The Second International Workshop on Myb Genes: foreword.
Blood cells, molecules & diseases 2001;27(2):407-8.
2000: Richard J D'Andrea; Thomas J Gonda
A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: insights from activated mutants of the common beta subunit.
Experimental hematology 2000;28(3):231-43.
2000: F Le; Frank C Stomski; Joanna M Woodcock; Angel F Lopez; Thomas J Gonda
The role of disulfide-linked dimerization in interleukin-3 receptor signaling and biological activity.
The Journal of biological chemistry 2000;275(7):5124-30.
2000: MP McCormack; Thomas J Gonda
Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor beta subunit.
Blood 2000;95(1):120-7.
1999: Rebecca A Keough; E Woollatt; J Crawford; G R Sutherland; S Plummer; G Casey; Thomas J Gonda
Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3.
Genomics 1999;62(3):483-9.
1999: MP McCormack; Thomas J Gonda
Myeloproliferative disorder and leukaemia in mice induced by different classes of constitutive mutants of the human IL-3/IL-5/GM-CSF receptor common beta subunit.
Oncogene 1999;18(51):7190-9.
1999: Brendan J Jenkins; F Le; Thomas J Gonda
A cell type-specific constitutive point mutant of the common beta-subunit of the human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 receptors requires the GM-CSF receptor alpha-subunit for activation.
The Journal of biological chemistry 1999;274(13):8669-77.
1998: Richard J D'Andrea; D Harrison-Findik; Carolyn M Butcher; John W Finnie; P Blumbergs; Paul A Bartley; MP McCormack; K Jones; R Rowland; Thomas J Gonda; Mathew A Vadas
Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common beta chain in transgenic mice.
The Journal of clinical investigation 1998;102(11):1951-60.
1998: Brendan J Jenkins; Timothy J Blake; Thomas J Gonda
Saturation mutagenesis of the beta subunit of the human granulocyte-macrophage colony-stimulating factor receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential beta subunit tyrosine phosphorylation.
Blood 1998;92(6):1989-2002.
1998: Fiona J Tavner; R Simpson; S Tashiro; D Favier; N A Jenkins; D J Gilbert; N G Copeland; Elizabeth M Macmillan; Jodi K Lutwyche; Rebecca A Keough; Shunsuke Ishii; Thomas J Gonda
Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.
Molecular and cellular biology 1998;18(2):989-1002.
1997: A Hogg; S Schirm; H Nakagoshi; Paul A Bartley; Shunsuke Ishii; John M Bishop; Thomas J Gonda
Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2.
Oncogene 1997;15(24):2885-98.
1997: MP McCormack; Thomas J Gonda
Expression of activated mutants of the human interleukin-3/interleukin-5/granulocyte-macrophage colony-stimulating factor receptor common beta subunit in primary hematopoietic cells induces factor-independent proliferation and differentiation.
Blood 1997;90(4):1471-81.
1997: Robyn Starr; Tracy A Willson; Elizabeth M Viney; L J Murray; J R Rayner; Brendan J Jenkins; Thomas J Gonda; Warren S Alexander; Donald Metcalf; Nicos A Nicola; Douglas J Hilton
A family of cytokine-inducible inhibitors of signalling.
Nature 1997;387(6636):917-21.
1997: Thomas J Gonda; Richard J D'Andrea
Activating mutations in cytokine receptors: implications for receptor function and role in disease.
Blood 1997;89(2):355-69.
1996: Brendan J Jenkins; Christopher J Bagley; J Woodcock; Angel F Lopez; Thomas J Gonda
Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation.
The Journal of biological chemistry 1996;271(47):29707-14.
1996: Andrew C W Zannettino; J R Rayner; Leonie K Ashman; Thomas J Gonda; Paul J Simmons
A powerful new technique for isolating genes encoding cell surface antigens using retroviral expression cloning.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):611-20.
1996: Thomas J Gonda; D Favier; Petranel T Ferrao; E M Macmillan; R Simpson; Fiona J Tavner
The c-myb negative regulatory domain.
Current topics in microbiology and immunology 1996;211():99-109.
1995: Petranel T Ferrao; E M Macmillan; Leonie K Ashman; Thomas J Gonda
Enforced expression of full length c-Myb leads to density-dependent transformation of murine haemopoietic cells.
Oncogene 1995;11(8):1631-8.
1995: Brendan J Jenkins; Richard J D'Andrea; Thomas J Gonda
Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling.
The EMBO journal 1995;14(17):4276-87.
1994: Richard J D'Andrea; J Rayner; P Moretti; A Lopez; G J Goodall; Thomas J Gonda; Mathew A Vadas
A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity.
Blood 1994;83(10):2802-8.
1994: J R Rayner; Thomas J Gonda
A simple and efficient procedure for generating stable expression libraries by cDNA cloning in a retroviral vector.
Molecular and cellular biology 1994;14(2):880-7.
1994: D Favier; Thomas J Gonda
Detection of proteins that bind to the leucine zipper motif of c-Myb.
Oncogene 1994;9(1):305-11.
1994: E M Macmillan; Thomas J Gonda
Murine myeloid cells transformed by myb require fibroblast-derived or autocrine growth factors in addition to granulocyte-macrophage colony-stimulating factor for proliferation.
Blood 1994;83(1):209-16.
1993: Thomas J Gonda; E M Macmillan; P V Townsend; A J Hapel
Differentiation state and responses to hematopoietic growth factors of murine myeloid cells transformed by myb.
Blood 1993;82(9):2813-22.
1993: Teruaki Nomura; N Sakai; Akinori Sarai; T Sudo; C Kanei-Ishii; R G Ramsay; D Favier; Thomas J Gonda; Shunsuke Ishii
Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper.
The Journal of biological chemistry 1993;268(29):21914-23.
1992: R G Ramsay; M A Thompson; J A Hayman; G Reid; Thomas J Gonda; R H Whitehead
Myb expression is higher in malignant human colonic carcinoma and premalignant adenomatous polyps than in normal mucosa.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(10):723-30.
1992: C Kanei-Ishii; E M MacMillan; Teruaki Nomura; Akinori Sarai; R G Ramsay; S Aimoto; Shunsuke Ishii; Thomas J Gonda
Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):3088-92.
1992: R G Ramsay; Shunsuke Ishii; Thomas J Gonda
Interaction of the Myb protein with specific DNA binding sites.
The Journal of biological chemistry 1992;267(8):5656-62.
1991: R G Ramsay; Shunsuke Ishii; Thomas J Gonda
Increase in specific DNA binding by carboxyl truncation suggests a mechanism for activation of Myb.
Oncogene 1991;6(10):1875-9.
1991: Y L Hu; R G Ramsay; C Kanei-Ishii; Shunsuke Ishii; Thomas J Gonda
Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain.
Oncogene 1991;6(9):1549-53.
1991: Thomas J Gonda
Targets for trans-activation by myb.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(1):22-3.
1989: Peter Sobieszczuk; Thomas J Gonda; Ashley R Dunn
Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene.
Nucleic acids research 1989;17(23):9593-611.
1989: J M Chang; Donald Metcalf; Thomas J Gonda; G R Johnson
Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice.
The Journal of clinical investigation 1989;84(5):1488-96.
1989: H Sakura; C Kanei-Ishii; T Nagase; H Nakagoshi; Thomas J Gonda; Shunsuke Ishii
Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5758-62.
1989: Thomas J Gonda; C Buckmaster; R G Ramsay
Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro.
The EMBO journal 1989;8(6):1777-83.
1989: Thomas J Gonda; R G Ramsay; G R Johnson
Murine myeloid cell lines derived by in vitro infection with recombinant c-myb retroviruses express myb from rearranged vector proviruses.
The EMBO journal 1989;8(6):1767-75.
1989: J M Chang; Donald Metcalf; Richard Lang; Thomas J Gonda; G R Johnson
Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression.
Blood 1989;73(6):1487-97.
1989: G R Johnson; Thomas J Gonda; Donald Metcalf; I K Hariharan; Suzanne Cory
A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.
The EMBO journal 1989;8(2):441-8.
1989: Y Nishina; H Nakagoshi; F Imamoto; Thomas J Gonda; Shunsuke Ishii
Trans-activation by the c-myb proto-oncogene.
Nucleic acids research 1989;17(1):107-17.
1989: I K Hariharan; G R Johnson; Thomas J Gonda; Donald Metcalf; Jerry M Adams; Suzanne Cory
Analysis of the leukemogenic properties of the bcr-v-abl and GM-CSF genes using a new retroviral vector.
Current topics in microbiology and immunology 1989;149():99-107.
1989: R G Ramsay; Shunsuke Ishii; Y Nishina; G Soe; Thomas J Gonda
Characterization of alternate and truncated forms of murine c-myb proteins.
Oncogene research 1989;4(4):259-69.
1987: Richard Lang; Donald Metcalf; R A Cuthbertson; I Lyons; E Stanley; A Kelso; G Kannourakis; D J Williamson; G K Klintworth; Thomas J Gonda
Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage.
Cell 1987;51(4):675-86.
1985: Richard Lang; Donald Metcalf; N M Gough; Ashley R Dunn; Thomas J Gonda
Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity.
Cell 1985;43(2 Pt 1):531-42.
1985: Thomas J Gonda; N M Gough; Ashley R Dunn; J de Blaquiere
Nucleotide sequence of cDNA clones of the murine myb proto-oncogene.
The EMBO journal 1985;4(8):2003-8.