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Steven Gonias

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Sumihisa Orita; Melanie Pollack; Kazuhisa Takahashi; Lawrence Wrabetz; Kazuyo Yamauchi; Alice De Corato; Mark Ellisman; M Laura Feltri; Alban Gaultier; Steven L Gonias; Kenneth Henry; Tetsuhiro Ishikawa; Elisabetta Mantuano; W Marie Campana
Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain.
Anthony Fernandez-Castaneda; Sanja Arandjelovic; Steven L Gonias; Kerri A Mowen; Ryan K Schlobach; Travis L Stiles; Alban Gaultier
Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris.
Jeanne M Bristow; Steven L Gonias; Minji Jo; Theresa A Reno; Richard L Klemke
Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.

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2013: Sumihisa Orita; Melanie Pollack; Kazuhisa Takahashi; Lawrence Wrabetz; Kazuyo Yamauchi; Alice De Corato; Mark Ellisman; M Laura Feltri; Alban Gaultier; Steven L Gonias; Kenneth Henry; Tetsuhiro Ishikawa; Elisabetta Mantuano; W Marie Campana
Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(13):5590-602.
2013: Anthony Fernandez-Castaneda; Sanja Arandjelovic; Steven L Gonias; Kerri A Mowen; Ryan K Schlobach; Travis L Stiles; Alban Gaultier
Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris.
The Journal of biological chemistry 2013;288(7):4538-48.
2013: Jeanne M Bristow; Steven L Gonias; Minji Jo; Theresa A Reno; Richard L Klemke
Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.
The Journal of biological chemistry 2013;288(1):123-31.
2013: Travis L Stiles; Elisabetta Mantuano; Travis Dickendesher; Anthony Fernandez-Castaneda; Alban Gaultier; Roman J Giger; Steven L Gonias
LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.
Journal of cell science 2013;126(Pt 1):209-20.
2012: Boryana M Eastman; Minji Jo; Shinako Takimoto; Drue L Webb; Steven L Gonias
A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen.
Cellular signalling 2012;24(9):1847-55.
2011: Elisabetta Mantuano; Sumihisa Orita; Kazuhisa Takahashi; Kazuyo Yamauchi; Tomonori Yamauchi; Steven L Gonias; Kenneth Henry; Nobuhiko Hiramatsu; Jonathan H Lin; W Marie Campana
The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(38):13376-85.
2011: Jingjing Hu; Minji Jo; Scott R VandenBerg; Webster K Cavenee; Frank B Furnari; Steven L Gonias
Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(38):15984-9.
2011: Yang Shi; Tomonori Yamauchi; Alban Gaultier; Shinako Takimoto; W Marie Campana; Steven L Gonias
Regulation of cytokine expression by Schwann cells in response to α2-macroglobulin binding to LRP1.
Journal of neuroscience research 2011;89(4):544-51.
2011: Steven L Gonias; Alban Gaultier; Minji Jo
Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1).
Current pharmaceutical design 2011;17(19):1962-9.
2010: Alban Gaultier; Gabriel Simon; Sherry Niessen; Melissa Dix; Shinako Takimoto; Benjamin F Cravatt; Steven L Gonias
LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome.
Journal of proteome research 2010;9(12):6689-95.
2010: Minji Jo; Boryana M Eastman; Drue L Webb; Konstantin Stoletov; Richard Klemke; Steven L Gonias
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells.
Cancer research 2010;70(21):8948-58.
2010: Matvey Gorovoy; Alban Gaultier; W Marie Campana; Gary S Firestein; Steven L Gonias
Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages.
Journal of leukocyte biology 2010;88(4):769-78.
2010: Grant C Bullock; Lorrie L Delehanty; Anne-Laure Talbot; Steven L Gonias; Wing-Hang Tong; Tracey A Rouault; Brian Dewar; Jeffrey M Macdonald; Jason J Chruma; Adam N Goldfarb
Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
Blood 2010;116(1):97-108.
2010: Steven L Gonias
Factor XII bridges coagulation and fibrinolysis again.
Blood 2010;115(24):4979-80.
2010: Elisabetta Mantuano; Minji Jo; Steven L Gonias; W Marie Campana
Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration.
The Journal of biological chemistry 2010;285(19):14259-66.
2010: Alban Gaultier; Margaret Hollister; Irene Reynolds; En-hui Hsieh; Steven L Gonias
LRP1 regulates remodeling of the extracellular matrix by fibroblasts.
Matrix biology : journal of the International Society for Matrix Biology 2010;29(1):22-30.
2009: Minji Jo; Robin D Lester; Valerie Montel; Boryana Eastman; Shinako Takimoto; Steven L Gonias
Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling.
The Journal of biological chemistry 2009;284(34):22825-33.
2009: Minji Jo; Shinako Takimoto; Valerie Montel; Steven L Gonias
The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice.
The American journal of pathology 2009;175(1):190-200.
2009: Alban Gaultier; Xiaohua Wu; Natacha Le Moan; Shinako Takimoto; Gatambwa Mukandala; Katerina Akassoglou; W Marie Campana; Steven L Gonias
Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis.
Journal of cell science 2009;122(Pt 8):1155-62.
2009: Chad E Green; Tiffany Liu; Valerie Montel; Gene Hsiao; Robin D Lester; Shankar Subramaniam; Steven L Gonias; Richard L Klemke
Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization.
PloS one 2009;4(8):e6713.
2009: Yang Shi; Elisabetta Mantuano; Gen Inoue; W Marie Campana; Steven L Gonias
Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.
Science signaling 2009;2(68):ra18.
2008: Elisabetta Mantuano; Gen Inoue; Xiaoqing Li; Kazuhisa Takahashi; Alban Gaultier; Steven L Gonias; W Marie Campana
The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(45):11571-82.
2008: Elisabetta Mantuano; Gatambwa Mukandala; Xiaoqing Li; W Marie Campana; Steven L Gonias
Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling.
The Journal of biological chemistry 2008;283(29):19904-11.
2008: Steven L Gonias
Urokinase: the identity crisis continues.
Blood 2008;112(1):8.
2008: Alban Gaultier; Sanja Arandjelovic; Sherry Niessen; Cheryl D Overton; MacRae F Linton; Sergio Fazio; W Marie Campana; Benjamin F Cravatt; Steven L Gonias
Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.
Blood 2008;111(11):5316-25.
2008: Marie-Florence Galliano; Eve Toulza; Nathalie Jonca; Steven L Gonias; Guy Serre; Marina Guerrin
Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis.
PloS one 2008;3(7):e2729.
2008: Alban Gaultier; Sanja Arandjelovic; Xiaoqing Li; Julie Janes; Nikola Dragojlovic; George P Zhou; Jenny Dolkas; Robert R Myers; Steven L Gonias; W Marie Campana
A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents.
The Journal of clinical investigation 2008;118(1):161-72.
2007: Konstantin Stoletov; Valerie Montel; Robin D Lester; Steven L Gonias; Richard L Klemke
High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17406-11.
2007: Valerie Montel; Alban Gaultier; Robin D Lester; W Marie Campana; Steven L Gonias
The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development.
Cancer research 2007;67(20):9817-24.
2007: Xiaohua Wu; Zhi-fang Li; Randolph Brooks; Elizabeth A Komives; Justin W Torpey; Eva Engvall; Steven L Gonias; G Diane Shelton
Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4939-44.
2007: Sanja Arandjelovic; Nikola Dragojlovic; Xiaoqing Li; Robert R Myers; W Marie Campana; Steven L Gonias
A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury.
Journal of neurochemistry 2007;103(2):694-705.
2007: Robin D Lester; Minji Jo; Valerie Montel; Shinako Takimoto; Steven L Gonias
uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells.
The Journal of cell biology 2007;178(3):425-36.
2007: Minji Jo; Keena S Thomas; S Takimoto; Alban Gaultier; E H Hsieh; Robin D Lester; Steven L Gonias
Urokinase receptor primes cells to proliferate in response to epidermal growth factor.
Oncogene 2007;26(18):2585-94.
2007: Jun-Li Luo; Wei Tan; Jill M Ricono; Olexandr Korchynskyi; Ming Zhang; Steven L Gonias; David A Cheresh; Michael Karin
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.
Nature 2007;446(7136):690-4.
2006: W Marie Campana; Xiaoqing Li; Nikola Dragojlovic; Julie Janes; Alban Gaultier; Steven L Gonias
The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(43):11197-207.
2006: Sanja Arandjelovic; Cristina L Van Sant; Steven L Gonias
Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1.
The Journal of biological chemistry 2006;281(25):17061-8.
2006: Alban Gaultier; Ana Maria Salicioni; Sanja Arandjelovic; Steven L Gonias
Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression.
The Journal of biological chemistry 2006;281(11):7332-40.
2006: Kebin Hu; Junwei Yang; Sakae Tanaka; Steven L Gonias; Wendy M Mars; Youhua Liu
Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression.
The Journal of biological chemistry 2006;281(4):2120-7.
2005: Lihua Wu; Steven L Gonias
The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts.
Journal of cellular biochemistry 2005;96(5):1021-33.
2005: Robin D Lester; Minji Jo; W Marie Campana; Steven L Gonias
Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia.
The Journal of biological chemistry 2005;280(47):39273-7.
2005: Xiaoqing Li; Steven L Gonias; W Marie Campana
Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury.
Glia 2005;51(4):254-65.
2005: Wendy M Mars; Minji Jo; Steven L Gonias
Activation of hepatocyte growth factor by urokinase-type plasminogen activator is ionic strength-dependent.
The Biochemical journal 2005;390(Pt 1):311-5.
2005: Sanja Arandjelovic; Brian D Hall; Steven L Gonias
Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1.
Archives of biochemistry and biophysics 2005;438(1):29-35.
2005: Minji Jo; Keena S Thomas; Nadzeya Marozkina; Tanay J Amin; Corinne M Silva; Sarah J Parsons; Steven L Gonias
Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator.
The Journal of biological chemistry 2005;280(17):17449-57.
2005: Joseph M Mettenburg; Sanja Arandjelovic; Steven L Gonias
A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity.
Journal of neurochemistry 2005;93(1):53-62.
2005: Joseph M Mettenburg; Steven L Gonias
Beta-amyloid peptide binds equivalently to binary and ternary alpha2-macroglobulin-protease complexes.
The protein journal 2005;24(2):89-93.
2004: Lihua Wu; Sanja Arandjelovic; Steven L Gonias
Effects of low density lipoprotein receptor-related protein-1 on the expression of platelet-derived growth factor beta-receptor in vitro.
Journal of cellular biochemistry 2004;93(6):1169-77.
2004: Steven L Gonias; Lihua Wu; Ana Maria Salicioni
Low density lipoprotein receptor-related protein: regulation of the plasma membrane proteome.
Thrombosis and haemostasis 2004;91(6):1056-64.
2004: Ana Maria Salicioni; Alban Gaultier; Cristina Brownlee; Michael K Cheezum; Steven L Gonias
Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface.
The Journal of biological chemistry 2004;279(11):10005-12.
2003: Caroline E Hope; Joseph M Mettenburg; Steven L Gonias; Steven T DeKosky; M Ilyas Kamboh; Charleen T Chu
Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion.
Neurobiology of disease 2003;14(3):504-12.
2003: Minji Jo; Keena S Thomas; Lihua Wu; Steven L Gonias
Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling.
The Journal of biological chemistry 2003;278(47):46692-8.
2003: John E Schrecengost; Robin D LeGallo; James C Boyd; Karel Moons; Steven L Gonias; C Edward Rose; David Bruns
Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism.
Clinical chemistry 2003;49(9):1483-90.
2003: Smitha Mathew; Sanja Arandjelovic; Wayne F Beyer; Steven L Gonias; Salvatore V Pizzo
Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions.
The Biochemical journal 2003;374(Pt 1):123-9.
2003: Sanja Arandjelovic; Tiffany A Freed; Steven L Gonias
Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta.
Biochemistry 2003;42(20):6121-7.
2003: Minji Jo; Keena S Thomas; Denise M O'Donnell; Steven L Gonias
Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor.
The Journal of biological chemistry 2003;278(3):1642-6.
2002: Zhong Ma; Keena S Thomas; Donna J Webb; Radim Moravec; Ana Maria Salicioni; Wendy M Mars; Steven L Gonias
Regulation of Rac1 activation by the low density lipoprotein receptor-related protein.
The Journal of cell biology 2002;159(6):1061-70.
2002: Ana Maria Salicioni; Kellie S Mizelle; Elena Loukinova; Irina Mikhailenko; Dudley K Strickland; Steven L Gonias
The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces.
The Journal of biological chemistry 2002;277(18):16160-6.
2002: Joseph M Mettenburg; Donna J Webb; Steven L Gonias
Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.
The Journal of biological chemistry 2002;277(15):13338-45.
2002: Minji Jo; Keena S Thomas; Avril V Somlyo; Andrew P Somlyo; Steven L Gonias
Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration.
The Journal of biological chemistry 2002;277(14):12479-85.
2002: Dudley K Strickland; Steven L Gonias; Scott Argraves
Diverse roles for the LDL receptor family.
Trends in endocrinology and metabolism: TEM 2002;13(2):66-74.
2001: Steven L Gonias; T A Hembrough; M Sankovic
Cytokeratin 8 functions as a major plasminogen receptor in select epithelial and carcinoma cells.
Frontiers in bioscience : a journal and virtual library 2001;6():D1403-11.
2001: Z Ma; Donna J Webb; Minji Jo; Steven L Gonias
Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.
Journal of cell science 2001;114(Pt 18):3387-96.
2001: Donna J Webb; Keena S Thomas; Steven L Gonias
Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth.
The Journal of cell biology 2001;152(4):741-52.
2000: Donna J Webb; D W Roadcap; A Dhakephalkar; Steven L Gonias
A 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB.
Protein science : a publication of the Protein Society 2000;9(10):1986-92.
2000: DH Nguyen; Donna J Webb; Andrew D Catling; Q Song; A Dhakephalkar; Michael J Weber; Kodi S Ravichandran; Steven L Gonias
Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells.
The Journal of biological chemistry 2000;275(25):19382-8.
2000: Steven L Gonias; A Carmichael; Joseph M Mettenburg; D W Roadcap; William Irvin; Donna J Webb
Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta.
The Journal of biological chemistry 2000;275(8):5826-31.
2000: T R Garber; Steven L Gonias; Donna J Webb
Interleukin-4 and IL-10 bind covalently to activated human alpha2-macroglobulin by a mechanism that requires Cys949.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(2):125-31.
2000: Donna J Webb; DH Nguyen; Steven L Gonias
Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion.
Journal of cell science 2000;113 ( Pt 1)():123-34.
1999: DH Nguyen; Andrew D Catling; Donna J Webb; M Sankovic; LA Walker; Avril V Somlyo; Michael J Weber; Steven L Gonias
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner.
The Journal of cell biology 1999;146(1):149-64.
1999: Isa M Hussaini; MD Brown; Alissa M Weaver; J Carpenter; LR Karns; Scott R Vandenberg; Steven L Gonias
Stable antisense RNA expression neutralizes the activity of low-density lipoprotein receptor-related protein and promotes urokinase accumulation in the medium of an astrocytic tumor cell line.
Antisense & nucleic acid drug development 1999;9(2):183-90.
1999: Donna J Webb; DH Nguyen; M Sankovic; Steven L Gonias
The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro.
The Journal of biological chemistry 1999;274(11):7412-20.
1999: Isa M Hussaini; MD Brown; LR Karns; J Carpenter; Gerard T Redpath; Steven L Gonias; Scott R Vandenberg
Epidermal growth factor differentially regulates low density lipoprotein receptor-related protein gene expression in neoplastic and fetal human astrocytes.
Glia 1999;25(1):71-84.
1998: K R Kralovich; L Li; T A Hembrough; Donna J Webb; LR Karns; Steven L Gonias
Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18.
Journal of protein chemistry 1998;17(8):845-54.
1998: Donna J Webb; Steven L Gonias
A modified human alpha 2-macroglobulin derivative that binds tumor necrosis factor-alpha and interleukin-1 beta with high affinity in vitro and reverses lipopolysaccharide toxicity in vivo in mice.
Laboratory investigation; a journal of technical methods and pathology 1998;78(8):939-48.
1998: Donna J Webb; J Wen; LR Karns; Michael Kurilla; Steven L Gonias
Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region.
The Journal of biological chemistry 1998;273(21):13339-46.
1998: DH Nguyen; Isa M Hussaini; Steven L Gonias
Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility.
The Journal of biological chemistry 1998;273(14):8502-7.
1998: Nancy L Harthun; Alissa M Weaver; Laurence H Brinckerhoff; Donna H Deacon; Steven L Gonias; Craig L Slingluff
Activated alpha 2-macroglobulin reverses the immunosuppressive activity in human breast cancer cell-conditioned medium by selectively neutralizing transforming growth factor-beta in the presence of interleukin-2.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1998;21(2):85-94.
1997: Jeffrey J Lysiak; Isa M Hussaini; Steven L Gonias
alpha 2-Macroglobulin synthesis by the human monocytic cell line THP-1 is differentiation state-dependent.
Journal of cellular biochemistry 1997;67(4):492-7.
1997: Alissa M Weaver; Jeffrey J Lysiak; Steven L Gonias
LDL receptor family-dependent and -independent pathways for the internalization and digestion of lipoprotein lipase-associated beta-VLDL by rat vascular smooth muscle cells.
Journal of lipid research 1997;38(9):1841-50.
1997: Donna J Webb; Steven L Gonias
Chemical modification of alpha2-macroglobulin to generate derivatives that bind transforming growth factor-beta with increased affinity.
FEBS letters 1997;410(2-3):249-53.
1997: Alissa M Weaver; Isa M Hussaini; Andrew P Mazar; Jack Henkin; Steven L Gonias
Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin.
The Journal of biological chemistry 1997;272(22):14372-9.
1997: MD Brown; Gary Banker; Isa M Hussaini; Steven L Gonias; Scott R Vandenberg
Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture.
Brain research 1997;747(2):313-7.
1996: Donna J Webb; Alissa M Weaver; T L Atkins-Brady; Steven L Gonias
Proteinases are isoform-specific regulators of the binding of transforming growth factor beta to alpha 2-macroglobulin.
The Biochemical journal 1996;320 ( Pt 2)():551-5.
1996: T A Hembrough; L Li; Steven L Gonias
Cell-surface cytokeratin 8 is the major plasminogen receptor on breast cancer cells and is required for the accelerated activation of cell-associated plasminogen by tissue-type plasminogen activator.
The Journal of biological chemistry 1996;271(41):25684-91.
1996: Donna J Webb; J Wen; Jeffrey J Lysiak; L Umans; Fred Van Leuven; Steven L Gonias
Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-out mouse.
The Journal of biological chemistry 1996;271(40):24982-8.
1996: Alissa M Weaver; M McCabe; I Kim; M M Allietta; Steven L Gonias
Epidermal growth factor and platelet-derived growth factor-BB induce a stable increase in the activity of low density lipoprotein receptor-related protein in vascular smooth muscle cells by altering receptor distribution and recycling.
The Journal of biological chemistry 1996;271(40):24894-900.
1996: T A Hembrough; K R Kralovich; L Li; Steven L Gonias
Cytokeratin 8 released by breast carcinoma cells in vitro binds plasminogen and tissue-type plasminogen activator and promotes plasminogen activation.
The Biochemical journal 1996;317 ( Pt 3)():763-9.
1996: Isa M Hussaini; Jonathan LaMarre; Jeffrey J Lysiak; LR Karns; Scott R Vandenberg; Steven L Gonias
Transcriptional regulation of LDL receptor-related protein by IFN-gamma and the antagonistic activity of TGF-beta(1) in the RAW 264.7 macrophage-like cell line.
Journal of leukocyte biology 1996;59(5):733-9.
1995: Alissa M Weaver; Gary K Owens; Steven L Gonias
Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity.
The Journal of biological chemistry 1995;270(51):30741-8.
1995: Donna J Webb; Isa M Hussaini; Alissa M Weaver; T L Atkins; C T Chu; S V Pizzo; Gary K Owens; Steven L Gonias
Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.
European journal of biochemistry / FEBS 1995;234(3):714-22.
1995: Donna J Webb; K P Crookston; N L Figler; Jonathan LaMarre; Steven L Gonias
Differences in the binding of transforming growth factor beta 1 to the acute-phase reactant and constitutively synthesized alpha-macroglobulins of rat.
The Biochemical journal 1995;312 ( Pt 2)():579-86.
1995: Cheryl Niemuller; K J Randall; D J Webb; Steven L Gonias; Jonathan LaMarre
Alpha 2-macroglobulin conformation determines binding affinity for activin A and plasma clearance of activin A/alpha 2-macroglobulin complex.
Endocrinology 1995;136(12):5343-9.
1995: Jeffrey J Lysiak; Isa M Hussaini; Donna J Webb; W F Glass; M Allietta; Steven L Gonias
Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line.
The Journal of biological chemistry 1995;270(37):21919-27.
1995: T A Hembrough; J Vasudevan; M M Allietta; W F Glass; Steven L Gonias
A cytokeratin 8-like protein with plasminogen-binding activity is present on the external surfaces of hepatocytes, HepG2 cells and breast carcinoma cell lines.
Journal of cell science 1995;108 ( Pt 3)():1071-82.
1994: B B Wolf; C A Gibson; Vivek Kapur; Isa M Hussaini; J M Musser; Steven L Gonias
Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface.
The Journal of biological chemistry 1994;269(48):30682-7.
1994: Donna J Webb; T L Atkins; K P Crookston; James K Burmester; S W Qian; Steven L Gonias
Transforming growth factor beta isoform 2-specific high affinity binding to native alpha 2-macroglobulin. Chimeras identify a sequence that determines affinity for native but not activated alpha 2-macroglobulin.
The Journal of biological chemistry 1994;269(48):30402-6.
1994: JE Humphries; Steven L Gonias; S V Pizzo; M E Williams
Life-long bleeding diathesis: effect of orthotopic liver transplantation.
American journal of clinical pathology 1994;102(6):816-20.
1994: B B Wolf; Steven L Gonias
Neurotrophin binding to human alpha 2-macroglobulin under apparent equilibrium conditions.
Biochemistry 1994;33(37):11270-7.
1994: Steven L Gonias; Jonathan LaMarre; K P Crookston; Donna J Webb; B B Wolf; M Beatriz S Lopes; H L Moses; M Anthony Hayes
Alpha 2-macroglobulin and the alpha 2-macroglobulin receptor/LRP. A growth regulatory axis.
Annals of the New York Academy of Sciences 1994;737():273-90.
1994: Jonathan LaMarre; J Vasudevan; Steven L Gonias
Plasmin cleaves betaglycan and releases a 60 kDa transforming growth factor-beta complex from the cell surface.
The Biochemical journal 1994;302 ( Pt 1)():199-205.
1994: K P Crookston; Steven L Gonias
The role of cysteine-949 in the binding of transforming growth factor-beta 1 and transforming growth factor-beta 2 to alpha 2-macroglobulin.
Biochemical and biophysical research communications 1994;200(3):1578-85.
1994: Vivekanand Reddy; P E Desorchers; S V Pizzo; Steven L Gonias; J A Sahakian; R L Levine; Stephen J Weiss
Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers.
The Journal of biological chemistry 1994;269(6):4683-91.
1994: M Beatriz S Lopes; C A Bogaev; Steven L Gonias; Scott R Vandenberg
Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells.
FEBS letters 1994;338(3):301-5.
1994: K P Crookston; Donna J Webb; B B Wolf; Steven L Gonias
Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions.
The Journal of biological chemistry 1994;269(2):1533-40.
1994: J S Turner; G T Redpath; JE Humphries; Steven L Gonias; Scott R Vandenberg
Plasmin modulates the thrombin-evoked calcium response in C6 glioma cells.
The Biochemical journal 1994;297 ( Pt 1)():175-9.
1993: George A Stouffer; Jonathan LaMarre; Steven L Gonias; Gary K Owens
Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response.
The Journal of biological chemistry 1993;268(24):18340-4.
1993: B B Wolf; J Vasudevan; Jack Henkin; Steven L Gonias
Nerve growth factor-gamma activates soluble and receptor-bound single chain urokinase-type plasminogen activator.
The Journal of biological chemistry 1993;268(22):16327-31.
1993: K P Crookston; Donna J Webb; Jonathan LaMarre; Steven L Gonias
Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations.
The Biochemical journal 1993;293 ( Pt 2)():443-50.
1993: J Vasudevan; JE Humphries; Steven L Gonias
Binding of anisoylated Lys-plasminogen streptokinase activator complex to cells in culture.
Thrombosis and haemostasis 1993;69(4):370-4.
1993: Steven L Gonias; L B Marshall; N L Figler; Isa M Hussaini; M D Moncino; S V Pizzo
Electron microscopy studies of alpha 2-macroglobulin subunit association after limited reduction with dithiothreitol.
Archives of biochemistry and biophysics 1993;302(1):42-8.
1993: Jonathan LaMarre; B B Wolf; E L Kittler; Peter J Quesenberry; Steven L Gonias
Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma.
The Journal of clinical investigation 1993;91(3):1219-24.
1993: B B Wolf; J Vasudevan; Steven L Gonias
Reaction of nerve growth factor gamma and 7S nerve growth factor complex with human and murine alpha 2-macroglobulin.
Biochemistry 1993;32(7):1875-82.
1993: P K Anonick; J K Yoo; Donna J Webb; Steven L Gonias
Characterization of the antiplasmin activity of human thrombospondin-1 in solution.
The Biochemical journal 1993;289 ( Pt 3)():903-9.
1993: JE Humphries; J Vasudevan; Steven L Gonias
Fibrinogenolytic and fibrinolytic activity of cell-associated plasmin.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(1):48-55.
1992: C M Pipan; W P Glasheen; T L Matthew; Steven L Gonias; L J Hwang; J A Jane; William D Spotnitz
Effects of antifibrinolytic agents on the life span of fibrin sealant.
The Journal of surgical research 1992;53(4):402-7.
1992: B B Wolf; M Beatriz S Lopes; Scott R Vandenberg; Steven L Gonias
Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain.
The American journal of pathology 1992;141(1):37-42.
1992: P K Anonick; J Vasudevan; Steven L Gonias
Antifibrinolytic activities of alpha-N-acetyl-L-lysine methyl ester, epsilon-aminocaproic acid, and tranexamic acid. Importance of kringle interactions and active site inhibition.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(6):708-16.
1992: L B Marshall; N L Figler; Steven L Gonias
Identification of alpha 2-macroglobulin conformational intermediates by electron microscopy and image analysis. Comparison of alpha 2-macroglobulin-thrombin and alpha 2-macroglobulin reacted with cis-dichlorodiammineplatinum(II) and trypsin.
The Journal of biological chemistry 1992;267(9):6347-52.
1992: Steven L Gonias
Alpha 2-macroglobulin: a protein at the interface of fibrinolysis and cellular growth regulation.
Experimental hematology 1992;20(3):302-11.
1992: Donna J Webb; K P Crookston; S W Hall; Steven L Gonias
Binding of transforming growth factor-beta 1 to immobilized human alpha 2-macroglobulin.
Archives of biochemistry and biophysics 1992;292(2):487-92.
1992: S W Hall; Jonathan LaMarre; L B Marshall; M Anthony Hayes; Steven L Gonias
Binding of transforming growth factor-beta 1 to methylamine-modified alpha 2-macroglobulin and to binary and ternary alpha 2-macroglobulin-proteinase complexes.
The Biochemical journal 1992;281 ( Pt 2)():569-75.
1992: Donna J Webb; Jonathan LaMarre; Steven L Gonias
Effect of human alpha-thrombin on the transforming growth factor-beta 1-binding activity of human alpha 2-macroglobulin.
Seminars in thrombosis and hemostasis 1992;18(3):305-10.
1991: S W Hall; JE Humphries; Steven L Gonias
Inhibition of cell surface receptor-bound plasmin by alpha 2-antiplasmin and alpha 2-macroglobulin.
The Journal of biological chemistry 1991;266(19):12329-36.
1991: Jonathan LaMarre; G K Wollenberg; Steven L Gonias; M Anthony Hayes
Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins.
Laboratory investigation; a journal of technical methods and pathology 1991;65(1):3-14.
1991: N L Figler; Dudley K Strickland; M Allietta; Steven L Gonias
Immunoelectron microscopy studies with a monoclonal antibody directed against a receptor recognition site epitope in human alpha 2-macroglobulin.
Journal of structural biology 1991;106(3):237-42.
1991: P K Anonick; Steven L Gonias
Soluble fibrin preparations inhibit the reaction of plasmin with alpha 2-macroglobulin. Comparison with alpha 2-antiplasmin and leupeptin.
The Biochemical journal 1991;275 ( Pt 1)():53-9.
1991: G K Wollenberg; Jonathan LaMarre; S Rosendal; Steven L Gonias; M Anthony Hayes
Binding of tumor necrosis factor alpha to activated forms of human plasma alpha 2 macroglobulin.
The American journal of pathology 1991;138(2):265-72.
1991: Jonathan LaMarre; G K Wollenberg; Steven L Gonias; M Anthony Hayes
Reaction of alpha 2-macroglobulin with plasmin increases binding of transforming growth factors-beta 1 and beta 2.
Biochimica et biophysica acta 1991;1091(2):197-204.
1991: Jonathan LaMarre; M Anthony Hayes; G K Wollenberg; Isa M Hussaini; S W Hall; Steven L Gonias
An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice.
The Journal of clinical investigation 1991;87(1):39-44.
1990: Isa M Hussaini; K Srikumar; Peter J Quesenberry; Steven L Gonias
Colony-stimulating factor-1 modulates alpha 2-macroglobulin receptor expression in murine bone marrow macrophages.
The Journal of biological chemistry 1990;265(32):19441-6.
1990: Isa M Hussaini; N L Figler; Steven L Gonias
The structure of alpha 2-macroglobulin-methylamine after papain digestion as determined by electron microscopy.
The Biochemical journal 1990;270(2):291-5.
1990: P K Anonick; B Wolf; Steven L Gonias
Regulation of plasmin, miniplasmin, and streptokinase-plasmin complex by alpha 2-antiplasmin, alpha 2-macroglobulin, and antithrombin III in the presence of heparin.
Thrombosis research 1990;59(3):449-62.
1990: M E Keohane; S W Hall; Scott R Vandenberg; Steven L Gonias
Secretion of alpha 2-macroglobulin, alpha 2-antiplasmin, and plasminogen activator inhibitor-1 by glioblastoma multiforme in primary organ culture.
Journal of neurosurgery 1990;73(2):234-41.
1990: S W Hall; Scott R Vandenberg; Steven L Gonias
Plasminogen carbohydrate side chains in receptor binding and enzyme activation: a study of C6 glioma cells and primary cultures of rat hepatocytes.
Journal of cellular biochemistry 1990;43(3):213-27.
1990: E N Baramova; John D Shannon; J B Bjarnason; Steven L Gonias; Jay W Fox
Interaction of hemorrhagic metalloproteinases with human alpha 2-macroglobulin.
Biochemistry 1990;29(4):1069-74.
1989: P K Anonick; W H Vetter; Steven L Gonias
Kinetics of the reaction of streptokinase-plasmin complex with purified human and mouse alpha 2-macroglobulin. Implications for mechanism.
The Biochemical journal 1989;264(3):745-52.
1989: Scott R Vandenberg; S G Britt; G T Redpath; Steven L Gonias
5-Hydroxytryptamine2 (5-HT2) structure-function relationships of the nitro and amino phenylpiperazines on intact human platelets.
Biochemical pharmacology 1989;38(23):4237-44.
1989: S W Hall; L L Braud; Steven L Gonias
Binding of bovine, ovine, porcine, canine, and rat plasminogen to rat hepatocytes and rat C6 glioma cells in vitro.
Biochemical and biophysical research communications 1989;164(3):1288-94.
1989: Steven L Gonias; W W Young; J W Fox
Cleavage of recombinant murine interferon-gamma by plasmin and miniplasmin.
Journal of interferon research 1989;9(5):517-29.
1989: S W Hall; Scott R Vandenberg; Steven L Gonias
Expression of plasminogen receptors on C6 glioma cells.
Brain research 1989;495(2):373-6.
1989: Steven L Gonias; L L Braud; W A Geary; Scott R Vandenberg
Plasminogen binding to rat hepatocytes in primary culture and to thin slices of rat liver.
Blood 1989;74(2):729-36.
1989: Steven L Gonias; N L Figler
Electron microscopy studies of alpha 2-macroglobulin conformational intermediates obtained by derivatization with cis-dichlorodiammineplatinum (II).
The Journal of biological chemistry 1989;264(16):9565-70.
1989: W A Geary; Steven L Gonias
Inactivation of alpha 2-antiplasmin by limited reaction with cis-dichlorodiammineplatinum (II)
Biochimica et biophysica acta 1989;994(1):1-6.
1989: Scott R Vandenberg; Steven L Gonias
Covalent complexes of albumin with serotonin, ketanserin and lysergic acid antagonize the activity of serotonin in human platelets.
Life sciences 1989;44(23):1777-85.
1988: S G Britt; Steven L Gonias; John M Sanders; Scott R Vandenberg
Agonist and antagonist activities of arylpiperazines at human platelet serotonin2 receptors.
The Journal of pharmacology and experimental therapeutics 1988;247(3):965-70.
1988: Steven L Gonias; N L Figler; L L Braud
Regulation of streptokinase-human plasmin complex by the plasma proteinase inhibitors alpha 2-antiplasmin and alpha 2-macroglobulin is species specific and temperature dependent.
Blood 1988;72(5):1658-64.
1988: Steven L Gonias; N L Figler
Alpha 2-macroglobulin is the primary inhibitor of miniplasmin in vitro and in vivo in the mouse. Comparison with alpha 2-antiplasmin in simultaneous reaction experiments.
The Biochemical journal 1988;255(2):725-30.
1988: Steven L Gonias; M M Allietta; S V Pizzo; F J Castellino; T W Tillack
Electron microscopic identification of exposed plasmin epitopes in alpha 2-macroglobulin-plasmin complex using monoclonal antibody-colloidal gold adducts.
The Journal of biological chemistry 1988;263(22):10903-6.