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Dolores González-Pacanowska

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Chemicals & Drugs

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Víctor M Castillo-Acosta; Daniel García-Caballero; Luis M Ruiz-Pérez; Antonio E Vidal; Fernando Aguilar-Pereyra; Dolores González-Pacanowska
Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.
Huaqing Cui; James A Brannigan; Juana Carrero-Lérida; Dolores González-Pacanowska; Kevin D Read; Luis M Ruiz-Pérez; Ana P G Silva; Jean L Whittingham; Keith S Wilson; Ian H Gilbert
Synthesis and evaluation of α-thymidine analogues as novel antimalarials.
Víctor M Castillo-Acosta; Fernando Aguilar-Pereyra; Jean-Mathieu Bart; Miguel Navarro; Luis M Ruiz-Pérez; Antonio E Vidal; Dolores González-Pacanowska
Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

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2013: Víctor M Castillo-Acosta; Daniel García-Caballero; Luis M Ruiz-Pérez; Antonio E Vidal; Fernando Aguilar-Pereyra; Dolores González-Pacanowska
Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.
Molecular and biochemical parasitology 2013;187(1):9-13.
2012: Huaqing Cui; James A Brannigan; Juana Carrero-Lérida; Dolores González-Pacanowska; Kevin D Read; Luis M Ruiz-Pérez; Ana P G Silva; Jean L Whittingham; Keith S Wilson; Ian H Gilbert
Synthesis and evaluation of α-thymidine analogues as novel antimalarials.
Journal of medicinal chemistry 2012;55(24):10948-57.
2012: Víctor M Castillo-Acosta; Fernando Aguilar-Pereyra; Jean-Mathieu Bart; Miguel Navarro; Luis M Ruiz-Pérez; Antonio E Vidal; Dolores González-Pacanowska
Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.
DNA repair 2012;11(12):986-95.
2012: Guiomar Pérez-Moreno; Carlos Rodrigues-Poveda; Luis M Ruiz-Pérez; Marco Sealey-Cardona; Julio A Urbina; Víctor Castillo-Acosta; Michael H Gelb; Dolores González-Pacanowska
Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.
International journal for parasitology 2012;42(11):975-89.
2012: Víctor M Castillo-Acosta; Miguel Navarro; Luis M Ruiz-Pérez; Antonio E Vidal; Fernando Aguilar-Pereyra; Dolores González-Pacanowska
Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.
The international journal of biochemistry & cell biology 2012;44(9):1555-68.
2012: Carlos A Rodrígues-Poveda; Dolores González-Pacanowska; Sergio H Szajnman; Juan B Rodríguez
2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.
Antimicrobial agents and chemotherapy 2012;56(8):4483-6.
2012: Noureddine El Aouad; Víctor González-Menéndez; Dolores González-Pacanowska; Jesús Martín; Francisco Javier Ortiz-López; Guiomar Pérez-Moreno; Gerald F Bills; Juan Cantizani; Luis M Ruiz-Pérez; Paula Sánchez; FRANCISCA VCICENTE; Fernando Reyes
Lasionectrin, a naphthopyrone from a Lasionectria sp.
Journal of natural products 2012;75(6):1228-30.
2012: Carlos A Rodrígues-Poveda; Dolores González-Pacanowska; Guiomar Pérez-Moreno; Julio A Urbina; Antonio E Vidal; Luis M Ruiz-Pérez
Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.
Molecular and biochemical parasitology 2012;182(1-2):83-7.
2011: Esther del Olmo; Bianca Barboza; Agustín Benito; Juana Carrero-Lérida; Louise D Chiaradia; Alberto Giménez; Dolores González-Pacanowska; José L López-Pérez; Antonio R Martínez; Alicia Moreno; Victoria Muñoz; Luis M Ruiz-Pérez; Arturo San Feliciano
Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.
European journal of medicinal chemistry 2011;46(11):5379-86.
2011: Shahienaz E Hampton; Nils Gunnar Johansson; Pia Kahnberg; Marcel Kaiser; J Alexander Musso-Buendía; Eliseo Recio; Shirley M Roberts; Alessandro Schipani; Mikhail Shevtsov; Jean L Whittingham; Keith S Wilson; Beatriz Baragaña; Cristina Bosch-Navarrete; James A Brannigan; Reto Brun; Dolores González-Pacanowska; Ian H Gilbert
Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
ChemMedChem 2011;6(10):1816-31.
2011: Eliseo Recio; Gian Filippo Ruda; Luis M Ruiz-Pérez; Antonio E Vidal; Ian H Gilbert; Ganasan Kasinathan; Alexander Musso-Buendía; Corinne Nguyen; Dolores González-Pacanowska
Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase.
European journal of medicinal chemistry 2011;46(8):3309-14.
2011: Glyn R Hemsworth; Olga V Moroz; Mark J Fogg; Benjamin Scott; Cristina Bosch-Navarrete; Dolores González-Pacanowska; Keith S Wilson
The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine.
The Journal of biological chemistry 2011;286(18):16470-81.
2011: Beatriz Baragaña; Orla McCarthy; Paula Sánchez; Cristina Bosch-Navarrete; Marcel Kaiser; Reto Brun; Jean L Whittingham; Shirley M Roberts; Xiao-Xiong Zhou; Keith S Wilson; Nils Gunnar Johansson; Dolores González-Pacanowska; Ian H Gilbert
β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.
Bioorganic & medicinal chemistry 2011;19(7):2378-91.
2011: Gian Filippo Ruda; Corinne Nguyen; Przemysław Ziemkowski; Krzysztof Felczak; Ganasan Kasinathan; Alexander Musso-Buendia; Christian Sund; Xiao Xiong Zhou; Marcel Kaiser; Luis M Ruiz-Pérez; Reto Brun; Tadeusz Kulikowski; Nils Gunnar Johansson; Dolores González-Pacanowska; Ian H Gilbert
Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase.
ChemMedChem 2011;6(2):309-20.
2010: Huaqing Cui; Gian Filippo Ruda; Juana Carrero-Lérida; Luis M Ruiz-Pérez; Ian H Gilbert; Dolores González-Pacanowska
Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.
European journal of medicinal chemistry 2010;45(11):5140-9.
2010: Huaqing Cui; Luis M Ruiz-Pérez; Dolores González-Pacanowska; Ian H Gilbert
Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.
Bioorganic & medicinal chemistry 2010;18(20):7302-9.
2010: Jean-Claude Dujardin; Dolores González-Pacanowska; Simon L Croft; Ole F Olesen; Gerald F Späth
Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas.
Trends in parasitology 2010;26(8):395-403.
2010: Jean L Whittingham; Juana Carrero-Lerida; James A Brannigan; Luis M Ruiz-Perez; Ana P G Silva; Mark J Fogg; Anthony J Wilkinson; Ian H Gilbert; Keith S Wilson; Dolores González-Pacanowska
Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase.
The Biochemical journal 2010;428(3):499-509.
2010: Indalecio Quesada-Soriano; Juan M Casas-Solvas; Eliseo Recio; Luis M Ruiz-Pérez; Antonio Vargas-Berenguel; Dolores González-Pacanowska; Luis García-Fuentes
Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases.
Biochimie 2010;92(2):178-86.
2009: Víctor M Castillo-Acosta; Luis M Ruiz-Pérez; WEI YANG; Dolores González-Pacanowska; Antonio E Vidal
Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.
Nucleic acids research 2009;37(6):1829-42.
2009: Yongcheng Song; Fu-Yang Lin; Fenglin Yin; Mary Hensler; Carlos A Rodrígues Poveda; Dushyant Mukkamala; Rong Cao; Hong Wang; Craig Morita; Dolores González-Pacanowska; Victor Nizet; Eric Oldfield
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Journal of medicinal chemistry 2009;52(4):976-88.
2009: Juana Carrero-Lérida; Guiomar Pérez-Moreno; Victor M Castillo-Acosta; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.
International journal for parasitology 2009;39(3):307-14.
2009: Juan A Musso-Buendía; Antonio E Vidal; Ganasan Kasinthan; Corinne Nguyen; Juana Carrero-Lérida; Luis M Ruiz-Pérez; Keith Wilson; Nils Gunnar Johansson; Ian H Gilbert; Dolores González-Pacanowska
Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni.
Journal of enzyme inhibition and medicinal chemistry 2009;24(1):111-6.
2008: Indalecio Quesada-Soriano; Isabel Leal; Juan M Casas-Solvas; Antonio Vargas-Berenguel; Carmen Barón; Luis M Ruiz-Pérez; Dolores González-Pacanowska; Luis García-Fuentes
Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.
Biochimica et biophysica acta 2008;1784(9):1347-55.
2008: Carmen Jiménez-Jiménez; Juana Carrero-Lérida; Marco Sealey-Cardona; Luis M Ruiz-Pérez; Julio A Urbina; Dolores González-Pacanowska
Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.
Molecular and biochemical parasitology 2008;160(1):52-9.
2008: Maria Paola Costi; Donatella Taramelli; Dolores González-Pacanowska
Opening opportunities for new drugs against neglected diseases.
ChemMedChem 2008;3(3):371-3.
2008: Víctor M Castillo-Acosta; Antonio M Estévez; Antonio E Vidal; Luis M Ruiz-Perez; Dolores González-Pacanowska
Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.
The international journal of biochemistry & cell biology 2008;40(12):2901-13.
2007: Antonio E Vidal; Maria Harkiolaki; Cláribel Gallego; Victor M Castillo-Acosta; Luis M Ruiz-Pérez; Keith Wilson; Dolores González-Pacanowska
Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major.
Journal of molecular biology 2007;373(4):827-38.
2007: Ramiro Téllez-Sanz; Zeyad Yassin; Victor Bernier-Villamor; Emilia Ortiz-Salmerón; Juan Alexander Musso-Buendia; Carmen Barón; Luis Miguel Ruíz-Pérez; Dolores González-Pacanowska; Luis García-Fuentes
Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase.
Biochimie 2007;89(8):972-80.
2007: Indalecio Quesada-Soriano; Juan Alexander Musso-Buendia; Ramiro Tellez-Sanz; Luis Miguel Ruíz-Pérez; Carmen Barón; Dolores González-Pacanowska; Luis García-Fuentes
Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives.
Biochimica et biophysica acta 2007;1774(7):936-45.
2007: Marco Sealey-Cardona; Simon Cammerer; Simon Jones; Luis M Ruiz-Pérez; Reto Brun; Ian H Gilbert; Julio A Urbina; Dolores González-Pacanowska
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
Antimicrobial agents and chemotherapy 2007;51(6):2123-9.
2006: Ludovic Gros; Victor Manuel Castillo-Acosta; Carmen Jiménez Jiménez; Marco Sealey-Cardona; Sofia Vargas; Antonio Manuel Estévez; Vanessa Yardley; Lauren Rattray; Simon L Croft; Luis M Ruiz-Perez; Julio A Urbina; Ian H Gilbert; Dolores González-Pacanowska
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.
Antimicrobial agents and chemotherapy 2006;50(8):2595-601.
2006: Aurora Ortiz-Gómez; Carmen Jiménez; Antonio M Estévez; Juana Carrero-Lérida; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.
Eukaryotic cell 2006;5(7):1057-64.
2005: Corinne Nguyen; Ganasan Kasinathan; Isabel Leal-Cortijo; Alexander Musso-Buendia; Marcel Kaiser; Reto Brun; Luis M Ruiz-Pérez; Nils Gunnar Johansson; Dolores González-Pacanowska; Ian H Gilbert
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target.
Journal of medicinal chemistry 2005;48(19):5942-54.
2005: Cláribel Gallego; Antonio M Estévez; Esther Fárez; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.
Molecular and biochemical parasitology 2005;141(2):191-7.
2005: John M Sanders; Yongcheng Song; Julian M W Chan; Yonghui Zhang; Samuel Jennings; Thomas Kosztowski; Sarah Odeh; Ryan Flessner; Christine Schwerdtfeger; Evangelia Kotsikorou; Gary A Meints; Aurora Ortiz Gómez; Dolores González-Pacanowska; Amy M Raker; Hong Wang; Ermond R Van Beek; Socrates E Papapoulos; Craig Morita; Eric Oldfield
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
Journal of medicinal chemistry 2005;48(8):2957-63.
2005: Soghra Khabnadideh; Didier Pez; Alexander Musso; Reto Brun; Luis M Ruiz Pérez; Dolores González-Pacanowska; Ian H Gilbert
Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
Bioorganic & medicinal chemistry 2005;13(7):2637-49.
2004: Irene Domínguez-Pérez; Ramiro Téllez-Sanz; Isabel Leal; Luis Miguel Ruíz-Pérez; Dolores González-Pacanowska; Luis García-Fuentes
Calorimetric determination of thermodynamic parameters of 2'-dUMP binding to Leishmania major dUTPase.
Biochimica et biophysica acta 2004;1702(1):33-40.
2004: Olga V Moroz; Maria Harkiolaki; Michael Galperin; Alexei A Vagin; Dolores González-Pacanowska; Keith S Wilson
The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases.
Journal of molecular biology 2004;342(5):1583-97.
2004: Silvia Orenes; Juliany C F Rodrigues; Carmen Jiménez Jiménez; Miranda Joyce-Menekse; Carlos Rodrigues; Simon L Croft; Vanessa Yardley; Kate de Luca-Fradley; Luis M Ruiz-Pérez; Julio A Urbina; Wanderley de Souza; Dolores González-Pacanowska; Ian H Gilbert
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
Antimicrobial agents and chemotherapy 2004;48(8):2937-50.
2004: María R Gómez-García; Luis M Ruiz-Pérez; Dolores González-Pacanowska; Aurelio Serrano
A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major.
FEBS letters 2004;560(1-3):158-66.
2004: Maria Harkiolaki; Eleanor J Dodson; Victor Bernier-Villamor; Johan P Turkenburg; Dolores González-Pacanowska; Keith S Wilson
The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold.
Structure (London, England : 1993) 2004;12(1):41-53.
2003: John M Sanders; Aurora Ortiz Gómez; Junhong Mao; Gary A Meints; Erin M Van Brussel; Agnieszka Burzynska; Pawel Kafarski; Dolores González-Pacanowska; Eric Oldfield
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.
Journal of medicinal chemistry 2003;46(24):5171-83.
2002: Juana Pérez Torres; Ana Camacho; Fernando Hidalgo-Zarco; Juana Pérez; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.
FEBS letters 2002;526(1-3):147-50.
2002: Ramón Hurtado-Guerrrero; Javier Peña-Díaz; Andrea Montalvetti; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.
FEBS letters 2002;510(3):141-4.
2001: Fernando Hidalgo-Zarco; A G Camacho; Victor Bernier-Villamor; J Nord; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major.
Protein science : a publication of the Protein Society 2001;10(7):1426-33.
2001: M E Fárez-Vidal; Cláribel Gallego; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Characterization of uracil-DNA glycosylase activity from Trypanosoma cruzi and its stimulation by AP endonuclease.
Nucleic acids research 2001;29(7):1549-55.
2000: Andrea Montalvetti; Javier Peña-Díaz; R Hurtado; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.
The Biochemical journal 2000;349(Pt 1):27-34.
2000: Ana Camacho; Fernando Hidalgo-Zarco; Victor Bernier-Villamor; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids.
The Biochemical journal 2000;346 Pt 1():163-8.
1999: Victor Bernier-Villamor; Ana Camacho; Dolores González-Pacanowska; E Cedergren-Zeppezauer; A Antson; Keith S Wilson
Crystallization and preliminary X-ray diffraction of Trypanosoma cruzi dUTPase.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 2):528-30.
1999: J Pérez; Cláribel Gallego; Juana Pérez Torres; Ana Camacho; Dolores González-Pacanowska; Luis M Ruiz-Pérez
Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli.
Nucleic acids research 1999;27(3):771-7.
1997: Ana Camacho; R Arrebola; J Peña-Diaz; Luis M Ruiz-Pérez; Dolores González-Pacanowska
Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.
The Biochemical journal 1997;325 ( Pt 2)():441-7.
1997: Ramiro Téllez-Sanz; Victor Bernier-Villamor; Luis García-Fuentes; Dolores González-Pacanowska; Carmen Barón
Thermodynamic characterization of the binding of dCMP to the Asn229Asp mutant of thymidylate synthase.
FEBS letters 1997;409(3):385-90.
1996: R Arrebola; A Olmo; Ana Camacho; Luis M Ruiz-Pérez; Dolores González-Pacanowska
A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments.
Molecular and biochemical parasitology 1996;79(1):129-33.
1995: Luis García-Fuentes; Pedro A Reche; O López-Mayorga; D V Santi; Dolores González-Pacanowska; Carmen Barón
Thermodynamic analysis of the binding of 5-fluoro-2'-deoxyuridine 5'-monophosphate to thymidylate synthase over a range of temperatures.
European journal of biochemistry / FEBS 1995;232(2):641-5.
1995: A Olmo; R Arrebola; V Bernier; Dolores González-Pacanowska; Luis M Ruiz-Pérez
Co-existence of circular and multiple linear amplicons in methotrexate-resistant Leishmania.
Nucleic acids research 1995;23(15):2856-64.