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Rosa González-Polo

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Rosa A González-Polo; Mireia Niso-Santano; José Manuel Fuentes; Lydia Alvarez-Erviti
Implication of autophagy in Parkinson's disease.
Rosa A González-Polo; Mireia Niso-Santano; Elisa Pizarro-Estrella; José M Bravo-San Pedro; Rubén Gómez-Sánchez; José M Fuentes
Autophagy, mitochondria and 3-nitropropionic acid joined in the same model.
José M Bravo-San Pedro; Vicente Climent; José M Fuentes; Rubén Gómez-Sánchez; Ana Gorostidi; Adolfo Lopez de Munain; Rakel López de Maturana; Mireia Niso-Santano; Elisa Pizarro-Estrella; Rosario Sanchez-Pernaute; Ana Aiastui-Pujana; Rosa A González-Polo
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.

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All Publications

2013: Rosa A González-Polo; Mireia Niso-Santano; José Manuel Fuentes; Lydia Alvarez-Erviti
Implication of autophagy in Parkinson's disease.
Parkinson's disease 2013;2013():436481.
2013: Rosa A González-Polo; Mireia Niso-Santano; Elisa Pizarro-Estrella; José M Bravo-San Pedro; Rubén Gómez-Sánchez; José M Fuentes
Autophagy, mitochondria and 3-nitropropionic acid joined in the same model.
British journal of pharmacology 2013;168(1):60-2.
2013: José M Bravo-San Pedro; Vicente Climent; José M Fuentes; Rubén Gómez-Sánchez; Ana Gorostidi; Adolfo Lopez de Munain; Rakel López de Maturana; Mireia Niso-Santano; Elisa Pizarro-Estrella; Rosario Sanchez-Pernaute; Ana Aiastui-Pujana; Rosa A González-Polo
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.
Cellular and molecular life sciences : CMLS 2013;70(1):121-36.
2012: José M Bravo-San Pedro; Rubén Gómez-Sánchez; Rosa A González-Polo; Mireia Niso-Santano; Elisa Pizarro-Estrella; José M Fuentes
Possible involvement of the relationship of LRRK2 and autophagy in Parkinson's disease.
Biochemical Society transactions 2012;40(5):1129-33.
2012: José M Bravo-San Pedro; Vicente Climent; José M Fuentes; Rubén Gómez-Sánchez; Ana Gorostidi; Rakel López de Maturana; Adolfo Lopez de Munain; Mireia Niso-Santano; Elisa Pizarro-Estrella; Rosario Sanchez-Pernaute; Ana Aiastui-Pujana; Rosa A González-Polo
The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.
Autophagy 2012;8(10):1537-9.
2012: José M Bravo-San Pedro; Rubén Gómez-Sánchez; Rosa A González-Polo; Mireia Niso-Santano; Elisa Pizarro-Estrella; José M Fuentes Rodríguez
Parkinson's disease: leucine-rich repeat kinase 2 and autophagy, intimate enemies.
Parkinson's disease 2012;2012():151039.
2011: Cyril Vidau; Luc P Belzunces; Rafael Blasco; José M Bravo-San Pedro; Jean-Luc Brunet; Rubén Gómez-Sánchez; Rosa A González-Polo; Mireia Niso-Santano; Elisa Pizarro-Estrella; José M Fuentes
Fipronil is a powerful uncoupler of oxidative phosphorylation that triggers apoptosis in human neuronal cell line SHSY5Y.
Neurotoxicology 2011;32(6):935-43.
2011: Mireia Niso-Santano; José M Bravo-San Pedro; Rubén Gómez-Sánchez; Vicente Climent; Germán Soler; José M Fuentes; Rosa A González-Polo
ASK1 overexpression accelerates paraquat-induced autophagy via endoplasmic reticulum stress.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(1):156-68.
2010: Rubén Gómez-Sánchez; José M Bravo-San Pedro; Mireia Niso-Santano; Germán Soler; José M Fuentes; Rosa A González-Polo
The neuroprotective effect of talipexole from paraquat-induced cell death in dopaminergic neuronal cells.
Neurotoxicology 2010;31(6):701-8.
2010: José M Morán; Miguel A Ortiz-Ortiz; Luz M Ruiz-Mesa; Mireia Niso-Santano; Jose M Bravosanpedro; Rubén Gómez-Sánchez; Rosa A González-Polo; José M Fuentes
Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2010;23(1):51-9.
2010: Mireia Niso-Santano; Rosa A González-Polo; José M Bravo-San Pedro; Rubén Gómez-Sánchez; Isabel Lastres-Becker; Miguel A Ortiz-Ortiz; Germán Soler; José M Morán; Antonio Cuadrado; José M Fuentes
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
Free radical biology & medicine 2010;48(10):1370-81.
2010: Miguel A Ortiz-Ortiz; José M Morán; Luz M Ruiz-Mesa; Mireia Niso-Santano; José M Bravo-SanPedro; Rubén Gómez-Sánchez; Rosa A González-Polo; José M Fuentes
Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells.
Neuroscience letters 2010;468(2):120-4.
2010: Rosa A González-Polo; Mireia Niso-Santano; Rubén Gómez-Sánchez; José M Bravo-San Pedro; José M Fuentes
DJ-1 as a modulator of autophagy: an hypothesis.
TheScientificWorldJournal 2010;10():1574-9.
2009: Miguel A Ortiz-Ortiz; José M Morán; Jose M Bravosanpedro; Rosa A González-Polo; Mireia Niso-Santano; Vellareddy Anantharam; Anumantha G Kanthasamy; Germán Soler; José M Fuentes
Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species.
Neurotoxicology 2009;30(6):1008-18.
2009: Miguel A Ortiz-Ortiz; José M Morán; Rosa A González-Polo; Mireia Niso-Santano; Germán Soler; José M Bravo-San Pedro; José M Fuentes
Nitric oxide-mediated toxicity in paraquat-exposed SH-SY5Y cells: a protective role of 7-nitroindazole.
Neurotoxicity research 2009;16(2):160-73.
2007: Rosa A González-Polo; Mireia Niso-Santano; Miguel A Ortíz-Ortíz; Ana Gómez-Martín; José M Morán; Lourdes García-Rubio; Javier Francisco-Morcillo; Concepción Zaragoza; Germán Soler; Jose M. Fuentes
Relationship between autophagy and apoptotic cell death in human neuroblastoma cells treated with paraquat: could autophagy be a "brake" in paraquat-induced apoptotic death?
Autophagy 2007;3(4):366-7.
2007: Rosa A González-Polo; Mireia Niso-Santano; Miguel A Ortíz-Ortíz; Ana Gómez-Martín; José M Morán; Lourdes García-Rubio; Javier Francisco-Morcillo; Concepción Zaragoza; Germán Soler; Jose M. Fuentes
Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):448-58.
2006: Mireia Niso-Santano; José M Morán; Lourdes García-Rubio; Ana Gómez-Martín; Rosa A González-Polo; Germán Soler; Jose M. Fuentes
Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(2):507-15.
2006: José M Morán; Rosa A González-Polo; Germán Soler; Jose M. Fuentes
TH1/TH2 cytokines: an easy model to study gene expression in immune cells.
CBE life sciences education 2006;5(3):287-95.
2005: Vanessa Donaire; Mireia Niso; José M Morán; Lourdes García; Rosa A González-Polo; Germán Soler; Jose M. Fuentes
Heat shock proteins protect both MPP(+) and paraquat neurotoxicity.
Brain research bulletin 2005;67(6):509-14.
2004: Rosa A González-Polo; Germán Soler; Jose M. Fuentes
MPP+: mechanism for its toxicity in cerebellar granule cells.
Molecular neurobiology 2004;30(3):253-64.
2004: Rosa A González-Polo; Andrea Rodríguez-Martín; José M Morán; Mireia Niso; Germán Soler; Jose M. Fuentes
Paraquat-induced apoptotic cell death in cerebellar granule cells.
Brain research 2004;1011(2):170-6.
2004: Rosa A González-Polo; Germán Soler; Andrea Rodríguezmartín; José M Morán; Jose M. Fuentes
Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants.
Cell biology international 2004;28(5):373-80.
2003: Rosa A González-Polo; Germán Soler; Juan C Alonso; Andrea Rodríguez-Martín; Jose M. Fuentes
MPP(+) causes inhibition of cellular energy supply in cerebellar granule cells.
Neurotoxicology 2003;24(2):219-25.
2003: Rosa A González-Polo; Germán Soler; Alberto Alvarez; Isabel Fabregat; Jose M. Fuentes
Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells.
Journal of neurochemistry 2003;84(2):305-15.
2002: Rangel M del Ara; Rosa A González-Polo; A Caro; E del Amo; L Palomo; E Hernández; Germán Soler; Jose M. Fuentes
Diagnostic performance of arginase activity in colorectal cancer.
Clinical and experimental medicine 2002;2(1):53-7.
2001: Rosa A González-Polo; A Mora; N Clemente; Guadalupe Sabio; Francisco Centeno; Germán Soler; Jose M. Fuentes
Mechanisms of MPP(+) incorporation into cerebellar granule cells.
Brain research bulletin 2001;56(2):119-23.
2001: Alfonso Mora; Guadalupe Sabio; Rosa A González-Polo; Ana Cuenda; Dario R Alessi; Juan C Alonso; Jose M. Fuentes; Germán Soler; Francisco Centeno
Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells.
Journal of neurochemistry 2001;78(1):199-206.
1999: Alfonso Mora; Rosa A González-Polo; Jose M. Fuentes; Germán Soler; Francisco Centeno
Different mechanisms of protection against apoptosis by valproate and Li+.
European journal of biochemistry / FEBS 1999;266(3):886-91.