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Frank Gonzalez

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
65
Gelboin, Harry
52
Krausz, Kristopher
32
Idle, Jeffrey
31
Fernandez-Salguero, Pedro
26
Ward, Jerrold
23
Kimura, Shioko
21
Korzekwa, Kenneth
19
Shou, Magang
16
Shah, Yatrik
15
Ma, Xiaochao
13
Akiyama, Taro
13
Yang, TJ
13
Chen, Chi
12
Buters, Jeroen
12
Yu, Ai-Ming

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Publications

TOP 3
Patterson Andrew D; Slanar Ondrej; Krausz Kristopher W; Li Fei; Höfer Constance C; Perlík Frantisek; Gonzalez Frank J; Idle Jeffrey R
Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation.
Cheng Jie; Ma Xiaochao; Krausz Kristopher W; Idle Jeffrey R; Gonzalez Frank J
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
Tyburski John B; Patterson Andrew D; Krausz Kristopher W; Slavík Josef; Fornace Albert J; Gonzalez Frank J; Idle Jeffrey R
Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice.

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All Publications

2009: Patterson Andrew D; Slanar Ondrej; Krausz Kristopher W; Li Fei; Höfer Constance C; Perlík Frantisek; Gonzalez Frank J; Idle Jeffrey R
Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation.
Journal of proteome research 2009;8(9):4293-300.
2009: Cheng Jie; Ma Xiaochao; Krausz Kristopher W; Idle Jeffrey R; Gonzalez Frank J
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(8):1611-21.
2009: Tyburski John B; Patterson Andrew D; Krausz Kristopher W; Slavík Josef; Fornace Albert J; Gonzalez Frank J; Idle Jeffrey R
Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice.
Radiation research 2009;172(1):42-57.
2009: Wang Xiaohui L; Suzuki Ryo; Lee Kevin; Tran Thien; Gunton Jenny E; Saha Asish K; Patti Mary-Elizabeth; Goldfine Allison; Ruderman Neil B; Gonzalez Frank J; Kahn C Ronald
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
Cell metabolism 2009;9(5):428-39.
2009: Cho Joo-Youn; Kang Dong Wook; Ma Xiaochao; Ahn Sung-Hoon; Krausz Kristopher W; Luecke Hans; Idle Jeffrey R; Gonzalez Frank J
Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation.
Journal of lipid research 2009;50(5):924-37.
2009: Chen Chi; Krausz Kristopher W; Shah Yatrik M; Idle Jeffrey R; Gonzalez Frank J
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
Chemical research in toxicology 2009;22(4):699-707.
2009: Nomoto Masahiro; Miyata Masaaki; Yin Shanai; Kurata Yasushi; Shimada Miki; Yoshinari Kouichi; Gonzalez Frank J; Suzuki Kokichi; Shibasaki Shigeki; Kurosawa Tohru; Yamazoe Yasushi
Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor.
Biological & pharmaceutical bulletin 2009;32(2):172-8.
2009: Shah Yatrik M; Matsubara Tsutomu; Ito Shinji; Yim Sun-Hee; Gonzalez Frank J
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency.
Cell metabolism 2009;9(2):152-64.
2009: Miyata Masaaki; Matsuda Yoshiki; Nomoto Masahiro; Takamatsu Yuki; Sato Nozomi; Hamatsu Mayumi; Dawson Paul A; Gonzalez Frank J; Yamazoe Yasushi
Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):338-44.
2008: Ma Xiaochao; Cheung Connie; Krausz Kristopher W; Shah Yatrik M; Wang Ting; Idle Jeffrey R; Gonzalez Frank J
A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(12):2506-12.
2008: Cheung Connie; Gonzalez Frank J
Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment.
The Journal of pharmacology and experimental therapeutics 2008;327(2):288-99.
2008: Ahn Sung-Hoon; Shah Yatrik M; Inoue Junko; Morimura Keiichirou; Kim Insook; Yim Sunhee; Lambert Gilles; Kurotani Reiko; Nagashima Kunio; Gonzalez Frank J; Inoue Yusuke
Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease.
Inflammatory bowel diseases 2008;14(7):908-20.
2008: Shah Yatrik M; Ito Shinji; Morimura Keiichirou; Chen Chi; Yim Sun-Hee; Haase Volker H; Gonzalez Frank J
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.
Gastroenterology 2008;134(7):2036-48, 2048.e1-3.
2008: Smith N F; Baker S D; Gonzalez F J; Harris J W; Figg W D; Sparreboom A
Modulation of erlotinib pharmacokinetics in mice by a novel cytochrome P450 3A4 inhibitor, BAS 100.
British journal of cancer 2008;98(10):1630-2.
2008: Matsusue Kimihiko; Kusakabe Takashi; Noguchi Takahiro; Takiguchi Shouichi; Suzuki Toshimitsu; Yamano Shigeru; Gonzalez Frank J
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.
Cell metabolism 2008;7(4):302-11.
2008: Ma Xiaochao; Chen Chi; Krausz Kristopher W; Idle Jeffrey R; Gonzalez Frank J
A metabolomic perspective of melatonin metabolism in the mouse.
Endocrinology 2008;149(4):1869-79.
2008: Gonzalez Frank J; Shah Yatrik M
PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.
Toxicology 2008;246(1):2-8.
2008: Chen Chi; Shah Yatrik M; Morimura Keiichirou; Krausz Kristopher W; Miyazaki Makoto; Richardson Terrilyn A; Morgan Edward T; Ntambi James M; Idle Jeffrey R; Gonzalez Frank J
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis.
Cell metabolism 2008;7(2):135-47.
2008: Patterson Andrew D; Li Henghong; Eichler Gabriel S; Krausz Kristopher W; Weinstein John N; Fornace Albert J; Gonzalez Frank J; Idle Jeffrey R
UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation.
Analytical chemistry 2008;80(3):665-74.
2008: Chen Chi; Krausz Kristopher W; Idle Jeffrey R; Gonzalez Frank J
Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice.
The Journal of biological chemistry 2008;283(8):4543-59.
2008: Wang Ting; Ma Xiaochao; Krausz Kristopher W; Idle Jeffrey R; Gonzalez Frank J
Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.
The Journal of pharmacology and experimental therapeutics 2008;324(2):674-84.
2008: Yang Qian; Nagano Tomokazu; Shah Yatrik; Cheung Connie; Ito Shinji; Gonzalez Frank J
The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(1):132-9.
2008: Gonzalez Frank J
Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription.
Drug metabolism and pharmacokinetics 2008;23(1):2-7.
2007: Kim Insook; Ahn Sung-Hoon; Inagaki Takeshi; Choi Mihwa; Ito Shinji; Guo Grace L; Kliewer Steven A; Gonzalez Frank J
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine.
Journal of lipid research 2007;48(12):2664-72.
2007: Nomoto Masahiro; Miyata Masaaki; Shimada Miki; Yoshinari Kouichi; Gonzalez Frank J; Shibasaki Shigeki; Kurosawa Tohru; Shindo Yasuhiro; Yamazoe Yasushi
ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output.
European journal of pharmacology 2007;574(2-3):192-200.
2007: Zhen Yueying; Krausz Kristopher W; Chen Chi; Idle Jeffrey R; Gonzalez Frank J
Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2136-51.
2007: Ito Shinji; Chen Chi; Satoh Junko; Yim Sunhee; Gonzalez Frank J
Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.
The Journal of clinical investigation 2007;117(7):1940-50.
2007: Ma Xiaochao; Shah Yatrik M; Guo Grace L; Wang Ting; Krausz Kristopher W; Idle Jeffrey R; Gonzalez Frank J
Rifaximin is a gut-specific human pregnane X receptor activator.
The Journal of pharmacology and experimental therapeutics 2007;322(1):391-8.
2007: Gonzalez Frank J
Animal models for human risk assessment: the peroxisome proliferator-activated receptor alpha-humanized mouse.
Nutrition reviews 2007;65(6 Pt 2):S2-6.
2007: Shah Yatrik M; Morimura Keiichirou; Yang Qian; Tanabe Tomotaka; Takagi Mitsuhiro; Gonzalez Frank J
Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation.
Molecular and cellular biology 2007;27(12):4238-47.
2007: Yang Qian; Ito Shinji; Gonzalez Frank J
Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis.
Carcinogenesis 2007;28(6):1171-7.
2007: Kim Insook; Morimura Keiichirou; Shah Yatrik; Yang Qian; Ward Jerrold M; Gonzalez Frank J
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice.
Carcinogenesis 2007;28(5):940-6.
2007: Shah Yatrik M; Ma Xiaochao; Morimura Keiichirou; Kim Insook; Gonzalez Frank J
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(4):G1114-22.
2007: Chen Chi; Ma Xiaochao; Malfatti Michael A; Krausz Kristopher W; Kimura Shioko; Felton James S; Idle Jeffrey R; Gonzalez Frank J
A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.
Chemical research in toxicology 2007;20(3):531-42.
2007: Ma Xiaochao; Idle Jeffrey R; Malfatti Michael A; Krausz Kristopher W; Nebert Daniel W; Chen Chong-Sheng; Felton James S; Waxman David J; Gonzalez Frank J
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis 2007;28(3):732-7.
2007: Giri Sarbani; Krausz Kristopher W; Idle Jeffrey R; Gonzalez Frank J
The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases.
Biochemical pharmacology 2007;73(4):561-73.
2007: Shah Yatrik M; Morimura Keiichirou; Gonzalez Frank J
Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(2):G657-66.
2007: Ma Xiaochao; Shah Yatrik; Cheung Connie; Guo Grace L; Feigenbaum Lionel; Krausz Kristopher W; Idle Jeffrey R; Gonzalez Frank J
The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(2):194-200.
2007: Gonzalez Frank J
The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(1):1-8.
2007: Gonzalez Frank J
CYP3A4 and pregnane X receptor humanized mice.
Journal of biochemical and molecular toxicology 2007;21(4):158-62.
2007: Chen Chi; Gonzalez Frank J; Idle Jeffrey R
LC-MS-based metabolomics in drug metabolism.
Drug metabolism reviews 2007;39(2-3):581-97.
2006: Guo Grace L; Santamarina-Fojo Silvia; Akiyama Taro E; Amar Marcelo J A; Paigen Beverly J; Brewer Bryan; Gonzalez Frank J
Effects of FXR in foam-cell formation and atherosclerosis development.
Biochimica et biophysica acta 2006;1761(12):1401-9.
2006: Meng Ling-hua; Shankavaram Uma; Chen Chi; Agama Keli; Fu Hai-qing; Gonzalez Frank J; Weinstein John; Pommier Yves
Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.
Cancer research 2006;66(19):9656-64.
2006: Yang Qian; Kurotani Reiko; Yamada Atsushi; Kimura Shioko; Gonzalez Frank J
Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice.
Endocrinology 2006;147(10):4772-80.
2006: Shin Mariko; Kim Insook; Inoue Yusuke; Kimura Shioko; Gonzalez Frank J
Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.
Molecular pharmacology 2006;70(4):1281-90.
2006: Yim Sun Hee; Shah Yatrik; Tomita Shuhei; Morris H Douglas; Gavrilova Oksana; Lambert Gilles; Ward Jerrold M; Gonzalez Frank J
Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice.
Hepatology (Baltimore, Md.) 2006;44(3):550-60.
2006: Zhen Yueying; Slanar Ondrej; Krausz Kristopher W; Chen Chi; Slavík Josef; McPhail Kerry L; Zabriskie T Mark; Perlík Frantisek; Gonzalez Frank J; Idle Jeffrey R
3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1563-74.
2006: Chen Chi; Meng Linghua; Ma Xiaochao; Krausz Kristopher W; Pommier Yves; Idle Jeffrey R; Gonzalez Frank J
Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).
The Journal of pharmacology and experimental therapeutics 2006;318(3):1330-42.
2006: Miyata Masaaki; Matsuda Yoshiki; Tsuchiya Hiroyuki; Kitada Hirotaka; Akase Takanori; Shimada Miki; Nagata Kiyoshi; Gonzalez Frank J; Yamazoe Yasushi
Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.
Drug metabolism and pharmacokinetics 2006;21(4):315-23.
2006: Matsusue Kimihiko; Miyoshi Aya; Yamano Shigeru; Gonzalez Frank J
Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR.
Molecular and cellular endocrinology 2006;256(1-2):23-33.
2006: Adachi M; Kurotani R; Morimura K; Shah Y; Sanford M; Madison B B; Gumucio D L; Marin H E; Peters J M; Young H A; Gonzalez F J
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease.
Gut 2006;55(8):1104-13.
2006: Miyata M; Watase H; Hori W; Shimada M; Nagata K; Gonzalez F J; Yamazoe Y
Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(7):631-44.
2006: Giri Sarbani; Idle Jeffrey R; Chen Chi; Zabriskie T Mark; Krausz Kristopher W; Gonzalez Frank J
A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse.
Chemical research in toxicology 2006;19(6):818-27.
2006: Ueda Rika; Iketaki Hiromi; Nagata Kiyoshi; Kimura Shioko; Gonzalez Frank J; Kusano Kazutomi; Yoshimura Tsutomu; Yamazoe Yasushi
A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes.
Molecular pharmacology 2006;69(6):1924-30.
2006: Ma Xiaochao; Idle Jeffrey R; Krausz Kristopher W; Tan Dun-Xian; Ceraulo Leopoldo; Gonzalez Frank J
Urinary metabolites and antioxidant products of exogenous melatonin in the mouse.
Journal of pineal research 2006;40(4):343-9.
2006: Morimura Keiichirou; Cheung Connie; Ward Jerrold M; Reddy Janardan K; Gonzalez Frank J
Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.
Carcinogenesis 2006;27(5):1074-80.
2006: Inoue Yusuke; Peters Luanne L; Yim Sun Hee; Inoue Junko; Gonzalez Frank J
Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression.
Journal of molecular medicine (Berlin, Germany) 2006;84(4):334-44.
2006: Gonzalez Frank J
Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stress.
The Biochemical journal 2006;394(Pt 2):e3-5.
2006: Cheung Connie; Yu Ai-Ming; Chen Chong-Sheng; Krausz Kristopher W; Byrd Linda G; Feigenbaum Lionel; Edwards Robert J; Waxman David J; Gonzalez Frank J
Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1328-34.
2006: Yang Qian; Yamada Atsushi; Kimura Shioko; Peters Jeffrey M; Gonzalez Frank J
Alterations in skin and stratified epithelia by constitutively activated PPARalpha.
The Journal of investigative dermatology 2006;126(2):374-85.
2006: Lee Hyunghee; Gonzalez Frank J; Yoon Michung
Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha.
Biochemical and biophysical research communications 2006;339(1):196-203.
2006: Inoue Yusuke; Yu Ai-Ming; Yim Sun Hee; Ma Xiaochao; Krausz Kristopher W; Inoue Junko; Xiang Charlie C; Brownstein Michael J; Eggertsen Gösta; Björkhem Ingemar; Gonzalez Frank J
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.
Journal of lipid research 2006;47(1):215-27.
2006: Gonzalez Frank J; Yu Ai-Ming
Cytochrome P450 and xenobiotic receptor humanized mice.
Annual review of pharmacology and toxicology 2006;46():41-64.
2005: Cheung Connie; Ma Xiaochao; Krausz Kristopher W; Kimura Shioko; Feigenbaum Lionel; Dalton Timothy P; Nebert Daniel W; Idle Jeffrey R; Gonzalez Frank J
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.
Chemical research in toxicology 2005;18(9):1471-8.
2005: Yu Ai-Ming; Fukamachi Katsumi; Krausz Kristopher W; Cheung Connie; Gonzalez Frank J
Potential role for human cytochrome P450 3A4 in estradiol homeostasis.
Endocrinology 2005;146(7):2911-9.
2005: Nicol Christopher J; Adachi Masahiro; Akiyama Taro E; Gonzalez Frank J
PPARgamma in endothelial cells influences high fat diet-induced hypertension.
American journal of hypertension 2005;18(4 Pt 1):549-56.
2005: Ma Xiaochao; Idle Jeffrey R; Krausz Kristopher W; Gonzalez Frank J
Metabolism of melatonin by human cytochromes p450.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(4):489-94.
2005: Cheung Connie; Yu Ai-Ming; Ward Jerrold M; Krausz Kristopher W; Akiyama Taro E; Feigenbaum Lionel; Gonzalez Frank J
The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(3):449-57.
2005: Gonzalez Frank J
Getting fat: two new players in molecular adipogenesis.
Cell metabolism 2005;1(2):85-6.
2005: Miyata Masaaki; Tozawa Aki; Otsuka Hijiri; Nakamura Toshifumi; Nagata Kiyoshi; Gonzalez Frank J; Yamazoe Yasushi
Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity.
The Journal of pharmacology and experimental therapeutics 2005;312(2):759-66.
2005: Gonzalez Frank J
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
Mutation research 2005;569(1-2):101-10.
2004: Kamiya Akihide; Inoue Yusuke; Kodama Tatsuhiko; Gonzalez Frank J
Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver.
FEBS letters 2004;578(1-2):63-8.
2004: Yang Qian; Gonzalez Frank J
Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice.
Biochemical pharmacology 2004;68(11):2143-50.
2004: Guo Grace L; Moffit Jeff S; Nicol Christopher J; Ward Jerrold M; Aleksunes Lauren A; Slitt Angela L; Kliewer Steven A; Manautou Jose E; Gonzalez Frank J
Enhanced acetaminophen toxicity by activation of the pregnane X receptor.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(2):374-80.
2004: Matsusue Kimihiko; Gavrilova Oksana; Lambert Gilles; Brewer H Bryan; Ward Jerrold M; Inoue Yusuke; LeRoith Derek; Gonzalez Frank J
Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.
Molecular endocrinology (Baltimore, Md.) 2004;18(11):2751-64.
2004: Inoue Yusuke; Inoue Junko; Lambert Gilles; Yim Sun Hee; Gonzalez Frank J
Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.
The Journal of biological chemistry 2004;279(43):44740-8.
2004: Kamiya Akihide; Gonzalez Frank J
TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices.
Hepatology (Baltimore, Md.) 2004;40(3):527-36.
2004: Matsusue Kimihiko; Peters Jeffrey M; Gonzalez Frank J
PPARbeta/delta potentiates PPARgamma-stimulated adipocyte differentiation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1477-9.
2004: Nicol Christopher J; Yoon Michung; Ward Jerrold M; Yamashita Masamichi; Fukamachi Katsumi; Peters Jeffrey M; Gonzalez Frank J
PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis.
Carcinogenesis 2004;25(9):1747-55.
2004: Cheung Connie; Akiyama Taro E; Ward Jerrold M; Nicol Christopher J; Feigenbaum Lionel; Vinson Charles; Gonzalez Frank J
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
Cancer research 2004;64(11):3849-54.
2004: Gonzalez Frank J
Cytochrome P450 humanised mice.
Human genomics 2004;1(4):300-6.
2004: Yu Ai-Ming; Idle Jeffrey R; Gonzalez Frank J
Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.
Drug metabolism reviews 2004;36(2):243-77.
2004: Akiyama Taro E; Lambert Gilles; Nicol Christopher J; Matsusue Kimihiko; Peters Jeffrey M; Brewer H Bryan; Gonzalez Frank J
Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet.
The Journal of biological chemistry 2004;279(20):20874-81.
2004: Andreola Fausto; Calvisi Diego F; Elizondo Guillermo; Jakowlew Sonia B; Mariano Jennifer; Gonzalez Frank J; De Luca Luigi M
Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion.
Hepatology (Baltimore, Md.) 2004;39(1):157-66.
2004: Andreola Fausto; Hayhurst Graham P; Luo Gang; Ferguson Stephen S; Gonzalez Frank J; Goldstein Joyce A; De Luca Luigi M
Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice.
The Journal of biological chemistry 2004;279(5):3434-8.
2004: Inoue Yusuke; Yu Ai-Ming; Inoue Junko; Gonzalez Frank J
Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation.
The Journal of biological chemistry 2004;279(4):2480-9.
2003: Gonzalez Frank J
Role of gene knockout and transgenic mice in the study of xenobiotic metabolism.
Drug metabolism reviews 2003;35(4):319-35.
2003: Cheung Connie; Akiyama Taro E; Kudo Gen; Gonzalez Frank J
Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice.
Biochemical pharmacology 2003;66(10):2011-20.
2003: Guo Grace L; Lambert Gilles; Negishi Masahiko; Ward Jerrold M; Brewer H Bryan; Kliewer Steven A; Gonzalez Frank J; Sinal Christopher J
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.
The Journal of biological chemistry 2003;278(46):45062-71.
2003: Gavrilova Oksana; Haluzik Martin; Matsusue Kimihiko; Cutson Jaime J; Johnson Lisa; Dietz Kelly R; Nicol Christopher J; Vinson Charles; Gonzalez Frank J; Reitman Marc L
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.
The Journal of biological chemistry 2003;278(36):34268-76.
2003: Hu Ming; Krausz Kristopher; Chen Jun; Ge Xia; Li Jianqi; Gelboin Harry L; Gonzalez Frank J
Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(7):924-31.
2003: Yu Ai-Ming; Idle Jeffrey R; Herraiz Tomas; Küpfer Adrian; Gonzalez Frank J
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.
Pharmacogenetics 2003;13(6):307-19.
2003: Kamiya Akihide; Inoue Yusuke; Gonzalez Frank J
Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development.
Hepatology (Baltimore, Md.) 2003;37(6):1375-84.
2003: Yim Sun Hee; Ward Jerrold M; Dragan Yvonne; Yamada Atsushi; Scacheri Peter C; Kimura Shioko; Gonzalez Frank J
Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles.
Toxicologic pathology 2003;31(3):295-303.
2003: Granvil Camille P; Yu Ai-Ming; Elizondo Guillermo; Akiyama Taro E; Cheung Connie; Feigenbaum Lionel; Krausz Kristopher W; Gonzalez Frank J
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):548-58.
2003: Kitada Hirotaka; Miyata Masaaki; Nakamura Toshifumi; Tozawa Aki; Honma Wataru; Shimada Miki; Nagata Kiyoshi; Sinal Christopher J; Guo Grace L; Gonzalez Frank J; Yamazoe Yasushi
Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.
The Journal of biological chemistry 2003;278(20):17838-44.
2003: Yu Ai-Ming; Idle Jeffrey R; Krausz Kristopher W; Küpfer Adrian; Gonzalez Frank J
Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.
The Journal of pharmacology and experimental therapeutics 2003;305(1):315-22.
2003: Kimura Shioko; Kawabe Mayumi; Yu Aiming; Morishima Hideki; Fernandez-Salguero Pedro; Hammons George J; Ward Jerrold M; Kadlubar Fred F; Gonzalez Frank J
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.
Carcinogenesis 2003;24(3):583-7.
2003: Yu Ai-Ming; Idle Jeffrey R; Byrd Linda G; Krausz Kristopher W; Küpfer Adrian; Gonzalez Frank J
Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.
Pharmacogenetics 2003;13(3):173-81.
2003: Matsusue Kimihiko; Haluzik Martin; Lambert Gilles; Yim Sun-Hee; Gavrilova Oksana; Ward Jerrold M; Brewer Bryan; Reitman Marc L; Gonzalez Frank J
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes.
The Journal of clinical investigation 2003;111(5):737-47.
2003: Akiyama Taro E; Gonzalez Frank J
Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors.
Biochimica et biophysica acta 2003;1619(3):223-34.
2003: Yu Ai-Ming; Granvil Camille P; Haining Robert L; Krausz Kristopher W; Corchero Javier; Küpfer Adrian; Idle Jeffrey R; Gonzalez Frank J
The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine.
The Journal of pharmacology and experimental therapeutics 2003;304(2):539-46.
2003: Gonzalez Frank J; Kimura Shioko
Study of P450 function using gene knockout and transgenic mice.
Archives of biochemistry and biophysics 2003;409(1):153-8.
2002: Gonzalez Frank J
Transgenic models in xenobiotic metabolism and toxicology.
Toxicology 2002;181-182():237-9.
2002: Gonzalez Frank J
The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis.
Molecular and cellular endocrinology 2002;193(1-2):71-9.
2002: Inoue Yusuke; Hayhurst Graham P; Inoue Junko; Mori Masataka; Gonzalez Frank J
Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo.
The Journal of biological chemistry 2002;277(28):25257-65.
2002: Granvil Camille P; Krausz Kristopher W; Gelboin Harry V; Idle Jeffrey R; Gonzalez Frank J
4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1025-32.
2002: Akiyama Taro E; Baumann Christopher T; Sakai Shuichi; Hager Gordon L; Gonzalez Frank J
Selective intranuclear redistribution of PPAR isoforms by RXR alpha.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):707-21.
2002: Akiyama Taro E; Sakai Shuichi; Lambert Gilles; Nicol Christopher J; Matsusue Kimihiko; Pimprale Satish; Lee Ying-Hue; Ricote Mercedes; Glass Christopher K; Brewer H Bryan; Gonzalez Frank J
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.
Molecular and cellular biology 2002;22(8):2607-19.
2002: Miyata Masaaki; Motoki Kazuko; Tamura Etsuko; Furukawa Masayuki; Gonzalez Frank J; Yamazoe Yasushi
Relative importance of maternal and embryonic microsomal epoxide hydrolase in 7,12-dimethylbenz[a]anthracene-induced developmental toxicity.
Biochemical pharmacology 2002;63(6):1077-84.
2002: Le Provost Fabienne; Riedlinger Gregory; Hee Yim Sun; Benedict Jamie; Gonzalez Frank J; Flaws Jodi; Hennighausen Lothar
The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility.
Genesis (New York, N.Y. : 2000) 2002;32(3):231-9.
2001: Corchero J; Granvil C P; Akiyama T E; Hayhurst G P; Pimprale S; Feigenbaum L; Idle J R; Gonzalez F J
The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.
Molecular pharmacology 2001;60(6):1260-7.
2001: Sinal C J; Yoon M; Gonzalez F J
Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids.
The Journal of biological chemistry 2001;276(50):47154-62.
2001: Krausz K W; Goldfarb I; Buters J T; Yang T J; Gonzalez F J; Gelboin H V
Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1410-23.
2001: Akiyama T E; Nicol C J; Fievet C; Staels B; Ward J M; Auwerx J; Lee S S; Gonzalez F J; Peters J M
Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.
The Journal of biological chemistry 2001;276(42):39088-93.
2001: Miyata M; Furukawa M; Takahashi K; Gonzalez F J; Yamazoe Y
Mechanism of 7,12-dimethylbenz[a]anthracene-induced immunotoxicity: role of metabolic activation at the target organ.
Japanese journal of pharmacology 2001;86(3):302-9.
2001: Gonzalez F J; Kimura S
Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice.
Mutation research 2001;477(1-2):79-87.
2001: Kiss A; Ortiz-Aguayo R; Sharp R; Merlino G; Thorgeirsson S S; Gonzalez F J; Peters J M
Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation.
Carcinogenesis 2001;22(6):975-9.
2001: Gonzalez F J
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis.
Toxicology letters 2001;120(1-3):199-208.
2001: Corchero J; Pimprale S; Kimura S; Gonzalez F J
Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.
Pharmacogenetics 2001;11(1):1-6.
2001: Hayhurst G P; Lee Y H; Lambert G; Ward J M; Gonzalez F J
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.
Molecular and cellular biology 2001;21(4):1393-403.
2000: Sinal C J; Miyata M; Tohkin M; Nagata K; Bend J R; Gonzalez F J
Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation.
The Journal of biological chemistry 2000;275(51):40504-10.
2000: Elizondo G; Corchero J; Sterneck E; Gonzalez F J
Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor alpha and CCAAT/enhancer-binding protein beta.
The Journal of biological chemistry 2000;275(50):39747-53.
2000: Aitchison K J; Gonzalez F J; Quattrochi L C; Sapone A; Zhao J H; Zaher H; Elizondo G; Bryant C; Munro J; Collier D A; Makoffa A I; Kerwin R W
Identification of novel polymorphisms in the 5' flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance.
Pharmacogenetics 2000;10(8):695-704.
2000: Tomita S; Sinal C J; Yim S H; Gonzalez F J
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha.
Molecular endocrinology (Baltimore, Md.) 2000;14(10):1674-81.
2000: Tohkin M; Fukuhara M; Elizondo G; Tomita S; Gonzalez F J
Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1A.
Molecular pharmacology 2000;58(4):845-51.
2000: Sinal C J; Tohkin M; Miyata M; Ward J M; Lambert G; Gonzalez F J
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.
Cell 2000;102(6):731-44.
2000: Ueno T; Tamura S; Frels W I; Shou M; Gonzalez F J; Kimura S
A transgenic mouse expressing human CYP1A2 in the pancreas.
Biochemical pharmacology 2000;60(6):857-63.
2000: Akiyama T E; Ward J M; Gonzalez F J
Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice.
The Journal of biological chemistry 2000;275(35):27117-22.
2000: Peters J M; Lee S S; Li W; Ward J M; Gavrilova O; Everett C; Reitman M L; Hudson L D; Gonzalez F J
Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta).
Molecular and cellular biology 2000;20(14):5119-28.
2000: Krausz K W; Goldfarb I; Yang T J; Gonzalez F J; Gelboin H V
An inhibitory monoclonal antibody to human cytochrome P450 that specifically binds and inhibits P4502C9II, an allelic variant of P4502C9 having a single amino acid change Arg144 Cys.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(6):619-25.
2000: Sapone A; Peters J M; Sakai S; Tomita S; Papiha S S; Dai R; Friedman F K; Gonzalez F J
The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.
Pharmacogenetics 2000;10(4):321-33.
2000: Elizondo G; Fernandez-Salguero P; Sheikh M S; Kim G Y; Fornace A J; Lee K S; Gonzalez F J
Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast.
Molecular pharmacology 2000;57(5):1056-63.
2000: Sai Y; Dai R; Yang T J; Krausz K W; Gonzalez F J; Gelboin H V; Shou M
Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(4):327-43.
2000: Peters J M; Rusyn I; Rose M L; Gonzalez F J; Thurman R G
Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.
Carcinogenesis 2000;21(4):823-6.
2000: Sata F; Sapone A; Elizondo G; Stocker P; Miller V P; Zheng W; Raunio H; Crespi C L; Gonzalez F J
CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.
Clinical pharmacology and therapeutics 2000;67(1):48-56.
2000: Aitchison K J; Jann M W; Zhao J H; Sakai T; Zaher H; Wolff K; Collier D A; Kerwin R W; Gonzalez F J
Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice.
Journal of psychopharmacology (Oxford, England) 2000;14(4):353-9.
1999: Gelboin H V; Krausz K W; Gonzalez F J; Yang T J
Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discovery.
Trends in pharmacological sciences 1999;20(11):432-8.
1999: Gonzalez F J; Kimura S
Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis.
Cancer letters 1999;143(2):199-204.
1999: Kimura S; Kawabe M; Ward J M; Morishima H; Kadlubar F F; Hammons G J; Fernandez-Salguero P; Gonzalez F J
CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice.
Carcinogenesis 1999;20(9):1825-30.
1999: Miyata M; Kudo G; Lee Y H; Yang T J; Gelboin H V; Fernandez-Salguero P; Kimura S; Gonzalez F J
Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene.
The Journal of biological chemistry 1999;274(34):23963-8.
1999: Peters J M; Morishima H; Ward J M; Coakley C J; Kimura S; Gonzalez F J
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
Toxicological sciences : an official journal of the Society of Toxicology 1999;50(1):82-9.
1999: Sai Y; Yang T J; Krausz K W; Gonzalez F J; Gelboin H V
An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver.
Pharmacogenetics 1999;9(2):229-37.
1999: Buters J T; Sakai S; Richter T; Pineau T; Alexander D L; Savas U; Doehmer J; Ward J M; Jefcoate C R; Gonzalez F J
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1977-82.
1999: Peters J M; Narotsky M G; Elizondo G; Fernandez-Salguero P M; Gonzalez F J; Abbott B D
Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice.
Toxicological sciences : an official journal of the Society of Toxicology 1999;47(1):86-92.
1999: Yang T J; Krausz K W; Sai Y; Gonzalez F J; Gelboin H V
Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(1):102-9.
1998: Gonzalez F J
The study of xenobiotic-metabolizing enzymes and their role in toxicity in vivo using targeted gene disruption.
Toxicology letters 1998;102-103():161-6.
1998: McLeod H L; Collie-Duguid E S; Vreken P; Johnson M R; Wei X; Sapone A; Diasio R B; Fernandez-Salguero P; van Kuilenberg A B; van Gennip A H; Gonzalez F J
Nomenclature for human DPYD alleles.
Pharmacogenetics 1998;8(6):455-9.
1998: Gonzalez F J; Fernandez-Salguero P
The aryl hydrocarbon receptor: studies using the AHR-null mice.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(12):1194-8.
1998: Peters J M; Aoyama T; Cattley R C; Nobumitsu U; Hashimoto T; Gonzalez F J
Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.
Carcinogenesis 1998;19(11):1989-94.
1998: Gonzalez F J; Peters J M; Cattley R C
Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.
Journal of the National Cancer Institute 1998;90(22):1702-9.
1998: Shou M; Martinet M; Korzekwa K R; Krausz K W; Gonzalez F J; Gelboin H V
Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver.
Pharmacogenetics 1998;8(5):391-401.
1998: Yang T J; Sai Y; Krausz K W; Gonzalez F J; Gelboin H V
Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver.
Pharmacogenetics 1998;8(5):375-82.
1998: Zaher H; Buters J T; Ward J M; Bruno M K; Lucas A M; Stern S T; Cohen S D; Gonzalez F J
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
Toxicology and applied pharmacology 1998;152(1):193-9.
1998: Ridge S A; Sludden J; Brown O; Robertson L; Wei X; Sapone A; Fernandez-Salguero P M; Gonzalez F J; Vreken P; van Kuilenburg A B; van Gennip A H; McLeod H L
Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.
British journal of clinical pharmacology 1998;46(2):151-6.
1998: Wei X; Elizondo G; Sapone A; McLeod H L; Raunio H; Fernandez-Salguero P; Gonzalez F J
Characterization of the human dihydropyrimidine dehydrogenase gene.
Genomics 1998;51(3):391-400.
1998: Zaher H; Fernandez-Salguero P M; Letterio J; Sheikh M S; Fornace A J; Roberts A B; Gonzalez F J
The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis.
Molecular pharmacology 1998;54(2):313-21.
1998: Yang T J; Krausz K W; Shou M; Yang S K; Buters J T; Gonzalez F J; Gelboin H V
Inhibitory monoclonal antibody to human cytochrome P450 2B6.
Biochemical pharmacology 1998;55(10):1633-40.
1998: Lee Y H; Sauer B; Gonzalez F J
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.
Molecular and cellular biology 1998;18(5):3059-68.
1998: Yang T J; Shou M; Korzekwa K R; Gonzalez F J; Gelboin H V; Yang S K
Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam.
Biochemical pharmacology 1998;55(6):889-96.
1998: Zaher H; Yang T J; Gelboin H V; Fernandez-Salguero P; Gonzalez F J
Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse.
Biochemical pharmacology 1998;55(2):235-8.
1998: Ridge S A; Sludden J; Wei X; Sapone A; Brown O; Hardy S; Canney P; Fernandez-Salguero P; Gonzalez F J; Cassidy J; McLeod H L
Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.
British journal of cancer 1998;77(3):497-500.
1997: Gelboin H V; Krausz K W; Shou M; Gonzalez F J; Yang T J
A monoclonal antibody inhibitory to human P450 2D6: a paradigm for use in combinatorial determination of individual P450 role in specific drug tissue metabolism.
Pharmacogenetics 1997;7(6):469-77.
1997: Fernandez-Salguero P M; Ward J M; Sundberg J P; Gonzalez F J
Lesions of aryl-hydrocarbon receptor-deficient mice.
Veterinary pathology 1997;34(6):605-14.
1997: Peters J M; Cattley R C; Gonzalez F J
Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.
Carcinogenesis 1997;18(11):2029-33.
1997: Peters J M; Hennuyer N; Staels B; Fruchart J C; Fievet C; Gonzalez F J; Auwerx J
Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice.
The Journal of biological chemistry 1997;272(43):27307-12.
1997: Lee Y H; Sauer B; Johnson P F; Gonzalez F J
Disruption of the c/ebp alpha gene in adult mouse liver.
Molecular and cellular biology 1997;17(10):6014-22.
1997: Code E L; Crespi C L; Penman B W; Gonzalez F J; Chang T K; Waxman D J
Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(8):985-93.
1997: Krausz K W; Yang T J; Gonzalez F J; Shou M; Gelboin H V
Inhibitory monoclonal antibodies to human cytochrome P450 2D6.
Biochemical pharmacology 1997;54(1):15-7.
1997: Andreola F; Fernandez-Salguero P M; Chiantore M V; Petkovich M P; Gonzalez F J; De Luca L M
Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism.
Cancer research 1997;57(14):2835-8.
1997: Fernandez-Salguero P M; Sapone A; Wei X; Holt J R; Jones S; Idle J R; Gonzalez F J
Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin.
Pharmacogenetics 1997;7(2):161-3.
1997: Lee Y H; Williams S C; Baer M; Sterneck E; Gonzalez F J; Johnson P F
The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain.
Molecular and cellular biology 1997;17(4):2038-47.
1997: Chen L; Buters J T; Hardwick J P; Tamura S; Penman B W; Gonzalez F J; Crespi C L
Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):399-405.
1997: Gonzalez F J
Recent update on the PPAR alpha-null mouse.
Biochimie 1997;79(2-3):139-44.
1997: Shou M; Korzekwa K R; Brooks E N; Krausz K W; Gonzalez F J; Gelboin H V
Role of human hepatic cytochrome P450 1A2 and 3A4 in the metabolic activation of estrone.
Carcinogenesis 1997;18(1):207-14.
1997: Gonzalez F J
The role of peroxisome proliferator activated receptor alpha in peroxisome proliferation, physiological homeostasis, and chemical carcinogenesis.
Advances in experimental medicine and biology 1997;422():109-25.
1997: Ridge S A; Brown O; McMurrough J; Fernandez-Salguero P; Evans W E; Gonzalez F J; McLeod H L
Mutations at codon 974 of the DPYD gene are a rare event.
British journal of cancer 1997;75(2):178-9.
1996: Gonzalez F J; Fernandez-Salguero P; Ward J M
The role of the aryl hydrocarbon receptor in animal development, physiological homeostasis and toxicity of TCDD.
The Journal of toxicological sciences 1996;21(5):273-7.
1996: Lee S S; Gonzalez F J
Targeted disruption of the peroxisome proliferator-activated receptor alpha gene, PPAR alpha.
Annals of the New York Academy of Sciences 1996;804():524-9.
1996: Shou M; Korzekwa K R; Krausz K W; Buters J T; Grogan J; Goldfarb I; Hardwick J P; Gonzalez F J; Gelboin H V
Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene.
Molecular carcinogenesis 1996;17(4):241-9.
1996: Shou M; Gonzalez F J; Gelboin H V
Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase.
Biochemistry 1996;35(49):15807-13.
1996: Shou M; Krausz K W; Gonzalez F J; Gelboin H V
Metabolic activation of the potent carcinogen dibenzo[a,l]pyrene by human recombinant cytochromes P450, lung and liver microsomes.
Carcinogenesis 1996;17(11):2429-33.
1996: Gelboin H V; Goldfarb I; Krausz K W; Grogan J; Korzekwa K R; Gonzalez F J; Shou M
Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 2E1.
Chemical research in toxicology 1996;9(6):1023-30.
1996: Fernandez-Salguero P M; Hilbert D M; Rudikoff S; Ward J M; Gonzalez F J
Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity.
Toxicology and applied pharmacology 1996;140(1):173-9.
1996: Buters J T; Tang B K; Pineau T; Gelboin H V; Kimura S; Gonzalez F J
Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2.
Pharmacogenetics 1996;6(4):291-6.
1996: Pineau T; Hudgins W R; Liu L; Chen L C; Sher T; Gonzalez F J; Samid D
Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs.
Biochemical pharmacology 1996;52(4):659-67.
1996: Wei X; McLeod H L; McMurrough J; Gonzalez F J; Fernandez-Salguero P
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.
The Journal of clinical investigation 1996;98(3):610-5.
1996: Peters J M; Zhou Y C; Ram P A; Lee S S; Gonzalez F J; Waxman D J
Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.
Molecular pharmacology 1996;50(1):67-74.
1996: Gonzalez F J
Use of transgenic animals in carcinogenesis studies.
Molecular carcinogenesis 1996;16(2):63-7.
1996: Lee S S; Buters J T; Pineau T; Fernandez-Salguero P; Gonzalez F J
Role of CYP2E1 in the hepatotoxicity of acetaminophen.
The Journal of biological chemistry 1996;271(20):12063-7.
1996: Shou M; Krausz K W; Gonzalez F J; Gelboin H V
Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450.
Archives of biochemistry and biophysics 1996;328(1):201-7.
1996: Fernandez-Salguero P M; Gonzalez F J
Targeted disruption of specific cytochromes P450 and xenobiotic receptor genes.
Methods in enzymology 1996;272():412-30.
1995: Furuya H; Fernandez-Salguero P; Gregory W; Taber H; Steward A; Gonzalez F J; Idle J R
Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy.
Pharmacogenetics 1995;5(6):389-92.
1995: Gonzalez F J; Fernandez-Salguero P; Lee S S; Pineau T; Ward J M
Xenobiotic receptor knockout mice.
Toxicology letters 1995;82-83():117-21.
1995: Gelboin H V; Krausz K W; Goldfarb I; Buters J T; Yang S K; Gonzalez F J; Korzekwa K R; Shou M
Inhibitory and non-inhibitory monoclonal antibodies to human cytochrome P450 3A3/4.
Biochemical pharmacology 1995;50(11):1841-50.
1995: Grogan J; Shou M; Andrusiak E A; Tamura S; Buters J T; Gonzalez F J; Korzekwa K R
Cytochrome P450 2A1, 2E1, and 2C9 cDNA-expression by insect cells and partial purification using hydrophobic chromatography.
Biochemical pharmacology 1995;50(9):1509-15.
1995: Gonzalez F J; Fernandez-Salguero P
Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency.
Trends in pharmacological sciences 1995;16(10):325-7.
1995: Fernandez-Salguero P; Gonzalez F J; Etienne M C; Milano G; Kimura S
Correlation between catalytic activity and protein content for the polymorphically expressed dihydropyrimidine dehydrogenase in human lymphocytes.
Biochemical pharmacology 1995;50(7):1015-20.
1995: Buters J T; Shou M; Hardwick J P; Korzekwa K R; Gonzalez F J
cDNA-directed expression of human cytochrome P450 CYP1A1 using baculovirus. Purification, dependency on NADPH-P450 oxidoreductase, and reconstitution of catalytic properties without purification.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(7):696-701.
1995: Lee S S; Pineau T; Drago J; Lee E J; Owens J W; Kroetz D L; Fernandez-Salguero P M; Westphal H; Gonzalez F J
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Molecular and cellular biology 1995;15(6):3012-22.
1995: Pineau T; Fernandez-Salguero P; Lee S S; McPhail T; Ward J M; Gonzalez F J
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5134-8.
1995: Fernandez-Salguero P; Pineau T; Hilbert D M; McPhail T; Lee S S; Kimura S; Nebert D W; Rudikoff S; Ward J M; Gonzalez F J
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.
Science (New York, N.Y.) 1995;268(5211):722-6.
1995: Liu S Y; Gonzalez F J
Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene.
DNA and cell biology 1995;14(4):285-93.
1995: Gonzalez F J
Genetic polymorphism and cancer susceptibility: fourteenth Sapporo Cancer Seminar.
Cancer research 1995;55(3):710-5.
1995: Meinsma R; Fernandez-Salguero P; Van Kuilenburg A B; Van Gennip A H; Gonzalez F J
Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.
DNA and cell biology 1995;14(1):1-6.
1995: Fernandez-Salguero P; Gonzalez F J
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.
Pharmacogenetics 1995;5 Spec No():S123-8.
1994: Herscher L L; Krishna M C; Cook J A; Coleman C N; Biaglow J E; Tuttle S W; Gonzalez F J; Mitchell J B
Protection against SR 4233 (Tirapazamine) aerobic cytotoxicity by the metal chelators desferrioxamine and tiron.
International journal of radiation oncology, biology, physics 1994;30(4):879-85.
1994: Yokota H; Fernandez-Salguero P; Furuya H; Lin K; McBride O W; Podschun B; Schnackerz K D; Gonzalez F J
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
The Journal of biological chemistry 1994;269(37):23192-6.
1994: Buters J T; Korzekwa K R; Kunze K L; Omata Y; Hardwick J P; Gonzalez F J
cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirus.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(5):688-92.
1994: Shou M; Korzekwa K R; Krausz K W; Crespi C L; Gonzalez F J; Gelboin H V
Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450.
Cancer letters 1994;83(1-2):305-13.
1994: Shou M; Korzekwa K R; Crespi C L; Gonzalez F J; Gelboin H V
The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol.
Molecular carcinogenesis 1994;10(3):159-68.
1994: Chang T K; Gonzalez F J; Waxman D J
Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.
Archives of biochemistry and biophysics 1994;311(2):437-42.
1994: Shou M; Grogan J; Mancewicz J A; Krausz K W; Gonzalez F J; Gelboin H V; Korzekwa K R
Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.
Biochemistry 1994;33(21):6450-5.
1994: Lee Y H; Alberta J A; Gonzalez F J; Waxman D J
Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression.
The Journal of biological chemistry 1994;269(20):14681-9.
1994: Czerwinski M; McLemore T L; Gelboin H V; Gonzalez F J
Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors.
Cancer research 1994;54(4):1085-91.
1994: Lee Y H; Yano M; Liu S Y; Matsunaga E; Johnson P F; Gonzalez F J
A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor.
Molecular and cellular biology 1994;14(2):1383-94.
1994: Wedlund P J; Kimura S; Gonzalez F J; Nebert D W
1462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of east Mediterranean descent.
Pharmacogenetics 1994;4(1):21-6.
1993: Imaoka S; Ogawa H; Kimura S; Gonzalez F J
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney.
DNA and cell biology 1993;12(10):893-9.
1993: Imaoka S; Wedlund P J; Ogawa H; Kimura S; Gonzalez F J; Kim H Y
Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase.
The Journal of pharmacology and experimental therapeutics 1993;267(2):1012-6.
1993: Kroetz D L; McBride O W; Gonzalez F J
Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms.
Biochemistry 1993;32(43):11606-17.
1993: Yokota H; Tamura S; Furuya H; Kimura S; Watanabe M; Kanazawa I; Kondo I; Gonzalez F J
Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.
Pharmacogenetics 1993;3(5):256-63.
1993: Gonzalez F J
Molecular biology of human xenobiotic-metabolizing cytochromes P450: role of vaccinia virus cDNA expression in evaluating catalytic function.
Toxicology 1993;82(1-3):77-88.
1993: Sher T; Yi H F; McBride O W; Gonzalez F J
cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor.
Biochemistry 1993;32(21):5598-604.
1993: Gonzalez F J; Liu S Y; Yano M
Regulation of cytochrome P450 genes: molecular mechanisms.
Pharmacogenetics 1993;3(1):51-7.
1992: Gonzalez F J; Crespi C L; Czerwinski M; Gelboin H V
Analysis of human cytochrome P450 catalytic activities and expression.
The Tohoku journal of experimental medicine 1992;168(2):67-72.
1992: Gonzalez F J
Human cytochromes P450: problems and prospects.
Trends in pharmacological sciences 1992;13(9):346-52.
1992: Smith S J; Korzekwa K R; Aoyama T; Gonzalez F J; Darbyshire J F; Sugiyama K; Gillette J R
12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(4):566-71.
1992: Yano M; Falvey E; Gonzalez F J
Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene.
Molecular and cellular biology 1992;12(6):2847-54.
1992: Park S S; Walker W; Aoyama T; Lapenson D P; Waxman D J; Gonzalez F J; Gelboin H V
Monoclonal antibodies to rat liver microsomal cytochrome b5.
Biochemical pharmacology 1992;43(10):2201-8.
1992: Hanioka N; Gonzalez F J; Lindberg N A; Liu G; Gelboin H V; Korzekwa K R
Site-directed mutagenesis of cytochrome P450s CYP2A1 and CYP2A2: influence of the distal helix on the kinetics of testosterone hydroxylation.
Biochemistry 1992;31(13):3364-70.
1992: Tamura S; Korzekwa K R; Kimura S; Gelboin H V; Gonzalez F J
Baculovirus-mediated expression and functional characterization of human NADPH-P450 oxidoreductase.
Archives of biochemistry and biophysics 1992;293(2):219-23.
1991: Krishna M C; DeGraff W; Tamura S; Gonzalez F J; Samuni A; Russo A; Mitchell J B
Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.
Cancer research 1991;51(24):6622-8.
1991: Mizuno K; Gonzalez F J; Kimura S
Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1.
Molecular and cellular biology 1991;11(10):4927-33.
1991: Waxman D J; Lapenson D P; Aoyama T; Gelboin H V; Gonzalez F J; Korzekwa K
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
Archives of biochemistry and biophysics 1991;290(1):160-6.
1991: Furuya H; Meyer U A; Gelboin H V; Gonzalez F J
Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.
Molecular pharmacology 1991;40(3):375-82.
1991: Gonzalez F J; Meyer U A
Molecular genetics of the debrisoquin-sparteine polymorphism.
Clinical pharmacology and therapeutics 1991;50(3):233-8.
1991: Czerwinski M; McLemore T L; Philpot R M; Nhamburo P T; Korzekwa K; Gelboin H V; Gonzalez F J
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism.
Cancer research 1991;51(17):4636-8.
1991: Bale A E; Mitchell A L; Gonzalez F J; McBride O W
Localization of CYP2F1 by multipoint linkage analysis and pulsed-field gel electrophoresis.
Genomics 1991;10(1):284-6.
1991: Gonzalez F J; Gelboin H V
Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression.
Progress in clinical and biological research 1991;372():11-20.
1991: Gonzalez F J; Ueno T; Umeno M; Song B J; Veech R L; Gelboin H V
Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1991;1():97-101.
1990: Gonzalez F J; Liu S Y; Kozak C A; Nebert D W
Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7.
DNA and cell biology 1990;9(10):771-6.
1990: Kikkawa F; Gonzalez F J; Kimura S
Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs upstream of the human thyroid peroxidase gene.
Molecular and cellular biology 1990;10(12):6216-24.
1990: Hanioka N; Kimura S; Meyer U A; Gonzalez F J
The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site.
American journal of human genetics 1990;47(6):994-1001.
1990: Matsunaga E; Zeugin T; Zanger U M; Aoyama T; Meyer U A; Gonzalez F J
Sequence requirements for cytochrome P-450IID1 catalytic activity. A single amino acid change (Ile380 Phe) specifically decreases Vmax of the enzyme for bufuralol but not debrisoquine hydroxylation.
The Journal of biological chemistry 1990;265(28):17197-201.
1990: Ueno T; Gonzalez F J
Transcriptional control of the rat hepatic CYP2E1 gene.
Molecular and cellular biology 1990;10(9):4495-505.
1990: Sugimura H; Caporaso N E; Shaw G L; Modali R V; Gonzalez F J; Hoover R N; Resau J H; Trump B F; Weston A; Harris C C
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
Carcinogenesis 1990;11(9):1527-30.
1990: Ueno T; Gonzalez F J
Complete sequence of the rat CYP2A3 gene specifically transcribed in lung.
Nucleic acids research 1990;18(15):4623-4.
1990: Aoyama T; Hardwick J P; Imaoka S; Funae Y; Gelboin H V; Gonzalez F J
Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha.
Journal of lipid research 1990;31(8):1477-82.
1990: Hanioka N; Korzekwa K; Gonzalez F J
Sequence requirements for cytochromes P450IIA1 and P450IIA2 catalytic activity: evidence for both specific and non-specific substrate binding interactions through use of chimeric cDNAs and cDNA expression.
Protein engineering 1990;3(7):571-5.
1990: Matsunaga E; Gonzalez F J
Specific cytosine demethylations within the first exons of the rat CYP2D3 and CYP2D5 genes are associated with activation of hepatic gene expression during development.
DNA and cell biology 1990;9(6):443-52.
1990: Aoyama T; Nagata K; Yamazoe Y; Kato R; Matsunaga E; Gelboin H V; Gonzalez F J
Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5425-9.
1990: Gonzalez F J; Nebert D W
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.
Trends in genetics : TIG 1990;6(6):182-6.
1990: Aoyama T; Yamano S; Guzelian P S; Gelboin H V; Gonzalez F J
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4790-3.
1990: Aoyama T; Korzekwa K; Nagata K; Gillette J; Gelboin H V; Gonzalez F J
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s.
Endocrinology 1990;126(6):3101-6.
1990: Nhamburo P T; Kimura S; McBride O W; Kozak C A; Gelboin H V; Gonzalez F J
The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping.
Biochemistry 1990;29(23):5491-9.
1990: Aoyama T; Korzekwa K; Matsunaga T; Nagata K; Gillette J; Gelboin H V; Gonzalez F J
cDNA-directed expression of rat P450s IIA1 and IIA2. Catalytic activities toward steroids and xenobiotics and comparison with the enzymes purified from liver.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(3):378-82.
1990: Aoyama T; Gelboin H V; Gonzalez F J
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450.
Cancer research 1990;50(7):2060-3.
1990: Matsunaga T; Nomoto M; Kozak C A; Gonzalez F J
Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7.
Biochemistry 1990;29(5):1329-41.
1990: Yamano S; Tatsuno J; Gonzalez F J
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.
Biochemistry 1990;29(5):1322-9.
1990: Robinson R C; Nagata K; Gelboin H V; Rifkind J; Gonzalez F J; Friedman F K
Developmental regulation of hepatic testosterone hydroxylases: simultaneous activation and repression of constitutively expressed cytochromes P450 in senescent rats.
Archives of biochemistry and biophysics 1990;277(1):42-6.
1990: Matsunaga E; Umeno M; Gonzalez F J
The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site.
Journal of molecular evolution 1990;30(2):155-69.
1990: Gonzalez F J; Aoyama T; Gelboin H V
Activation of promutagens by human cDNA-expressed cytochrome P450s.
Progress in clinical and biological research 1990;340B():77-86.
1990: Gonzalez F J
Hereditary polymorphisms of human drug metabolizing enzymes and cancer susceptibility.
Birth defects original article series 1990;26(1):17-42.
1990: Gelboin H V; Park S S; Aoyama T; Fujino T; Crespi C L; Gonzalez F J
Mapping of cytochrome P-450 distribution and function with monoclonal antibodies and cDNA expression.
Princess Takamatsu symposia 1990;21():3-16.
1990: Gonzalez F J; Gelboin H V
Transcriptional and posttranscriptional regulation of CYP2E1, an N-nitrosodimethylamine demethylase.
Princess Takamatsu symposia 1990;21():157-64.
1989: Aoyama T; Korzekwa K; Nagata K; Adesnik M; Reiss A; Lapenson D P; Gillette J; Gelboin H V; Waxman D J; Gonzalez F J
Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine.
The Journal of biological chemistry 1989;264(35):21327-33.
1989: Kimura S; Umeno M; Skoda R C; Meyer U A; Gonzalez F J
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.
American journal of human genetics 1989;45(6):889-904.
1989: Asseffa A; Smith S J; Nagata K; Gillette J; Gelboin H V; Gonzalez F J
Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus.
Archives of biochemistry and biophysics 1989;274(2):481-90.
1989: Nhamburo P T; Gonzalez F J; McBride O W; Gelboin H V; Kimura S
Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping.
Biochemistry 1989;28(20):8060-6.
1989: Matsunaga E; Zanger U M; Hardwick J P; Gelboin H V; Meyer U A; Gonzalez F J
The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.
Biochemistry 1989;28(18):7349-55.
1989: Kimura S; Hardwick J P; Kozak C A; Gonzalez F J
The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.
DNA (Mary Ann Liebert, Inc.) 1989;8(7):517-25.
1989: Kimura S; Hanioka N; Matsunaga E; Gonzalez F J
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
DNA (Mary Ann Liebert, Inc.) 1989;8(7):503-16.
1989: Yamano S; Nhamburo P T; Aoyama T; Meyer U A; Inaba T; Kalow W; Gelboin H V; McBride O W; Gonzalez F J
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.
Biochemistry 1989;28(18):7340-8.
1989: Yamano S; Aoyama T; McBride O W; Hardwick J P; Gelboin H V; Gonzalez F J
Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7.
Molecular pharmacology 1989;36(1):83-8.
1989: Yamano S; Nagata K; Yamazoe Y; Kato R; Gelboin H V; Gonzalez F J
cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3).
Nucleic acids research 1989;17(12):4888.
1989: Kimura S; Kozak C A; Gonzalez F J
Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene.
Biochemistry 1989;28(9):3798-803.
1989: Aoyama T; Gonzalez F J; Gelboin H V
Human cDNA-expressed cytochrome P450 IA2: mutagen activation and substrate specificity.
Molecular carcinogenesis 1989;2(4):192-8.
1989: Aoyama T; Gonzalez F J; Gelboin H V
Mutagen activation by cDNA-expressed P(1)450, P(3)450, and P450a.
Molecular carcinogenesis 1989;1(4):253-9.
1988: Umeno M; McBride O W; Yang C S; Gelboin H V; Gonzalez F J
Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.
Biochemistry 1988;27(25):9006-13.
1988: Matsunaga T; Nagata K; Holsztynska E J; Lapenson D P; Smith A; Kato R; Gelboin H V; Waxman D J; Gonzalez F J
Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase.
The Journal of biological chemistry 1988;263(34):17995-8002.
1988: Long R M; Satoh H; Martin B M; Kimura S; Gonzalez F J; Pohl L R
Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence for a multigene family.
Biochemical and biophysical research communications 1988;156(2):866-73.
1988: Umeno M; Morris S; Matsunaga E; Gelboin H V; Gonzalez F J
Sequence of the 5' end of the developmentally regulated rat P450 PB1 (P450IIC6) gene.
Nucleic acids research 1988;16(13):6249.
1988: Umeno M; Song B J; Kozak C; Gelboin H V; Gonzalez F J
The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation.
The Journal of biological chemistry 1988;263(10):4956-62.
1988: Gonzalez F J; Schmid B J; Umeno M; Mcbride O W; Hardwick J P; Meyer U A; Gelboin H V; Idle J R
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
DNA (Mary Ann Liebert, Inc.) 1988;7(2):79-86.
1988: Gonzalez F J; Vilbois F; Hardwick J P; McBride O W; Nebert D W; Gelboin H V; Meyer U A
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
Genomics 1988;2(2):174-9.
1988: Gonzalez F J; Skoda R C; Kimura S; Umeno M; Zanger U M; Nebert D W; Gelboin H V; Hardwick J P; Meyer U A
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.
Nature 1988;331(6155):442-6.
1987: Kimura S; Pastewka J; Gelboin H V; Gonzalez F J
cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.
Nucleic acids research 1987;15(23):10053-4.
1987: McBride O W; Umeno M; Gelboin H V; Gonzalez F J
A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E).
Nucleic acids research 1987;15(23):10071.

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