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Frank Gonzalez

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Huichang Bi; Caroline H Johnson; Kristopher W Krausz; Fei Li; Soumen K Manna; Frank J Gonzalez
Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells.
Soumen K Manna; Jessica A Bonzo; Jeffrey R Idle; Kristopher W Krausz; Frank J Gonzalez
Metabolomics Reveals Aging-associated Attenuation of Noninvasive Radiation Biomarkers in Mice: Potential Role of Polyamine Catabolism and Incoherent DNA Damage-repair.
Tsutomu Matsubara; Fei Li; Frank J Gonzalez
FXR signaling in the enterohepatic system.

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2013: Huichang Bi; Caroline H Johnson; Kristopher W Krausz; Fei Li; Soumen K Manna; Frank J Gonzalez
Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells.
Analytical and bioanalytical chemistry 2013;405(15):5279-89.
2013: Soumen K Manna; Jessica A Bonzo; Jeffrey R Idle; Kristopher W Krausz; Frank J Gonzalez
Metabolomics Reveals Aging-associated Attenuation of Noninvasive Radiation Biomarkers in Mice: Potential Role of Polyamine Catabolism and Incoherent DNA Damage-repair.
Journal of proteome research 2013;12(5):2269-81.
2013: Tsutomu Matsubara; Fei Li; Frank J Gonzalez
FXR signaling in the enterohepatic system.
Molecular and cellular endocrinology 2013;368(1-2):17-29.
2013: Fei Li; James B Mitchell; Xiaoyan Pang; Chi Chen; John A Cook; Frank J Gonzalez; Changtao Jiang; Kristopher W Krausz; Murali C Krishna; Andrew D Patterson
Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology.
Journal of proteome research 2013;12(3):1369-76.
2013: Caroline H Johnson; Dong Wook Kang; Kristopher W Krausz; Hans Luecke; Jessica A Bonzo; Jie Cheng; Jeffrey R Idle; Frank J Gonzalez
Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(2):406-13.
2013: Jie Cheng; Kristopher W Krausz; Feng Li; Xiaochao Ma; Frank J Gonzalez
CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid.
Toxicology and applied pharmacology 2013;266(2):245-53.
2013: Huichang Bi; Caroline H Johnson; Kristopher W Krausz; Fei Li; Aijuan Qu; Frank J Gonzalez
Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity.
Evidence-based complementary and alternative medicine : eCAM 2013;2013():985257.
2013: Jung-Hwan Kim; Kristopher W Krausz; Tomotaka Tanabe; Satoshi Yamaori; Caroline H Johnson; Shigeaki Kato; Frank J Gonzalez
Implication of intestinal VDR deficiency in inflammatory bowel disease.
Biochimica et biophysica acta 2013;1830(1):2118-28.
2012: Tsutomu Matsubara; Misako Sato; Naoki Tanaka; Lalage M Wakefield; Kazuo Ikeda; Dong Wook Kang; Kristopher W Krausz; Hans Luecke; Kathleen C Flanders; Frank J Gonzalez
TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury.
Journal of lipid research 2012;53(12):2698-707.
2012: Tsutomu Matsubara; Andrew D Patterson; Yatrik M Shah; Naoki Tanaka; Dong Wook Kang; Kristopher W Krausz; Hans Luecke; Soumen K Manna; Erik R Anderson; Frank J Gonzalez
Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.
Cell metabolism 2012;16(5):634-44.
2012: Zhong-Ze Fang; Kristopher W Krausz; Fei Li; Naoki Tanaka; Jie Cheng; Frank J Gonzalez
Metabolic map and bioactivation of the anti-tumour drug noscapine.
British journal of pharmacology 2012;167(6):1271-86.
2012: Caroline H Johnson; John F Kalinich; Dong Wook Kang; Kristopher W Krausz; Hans Luecke; Andrew D Patterson; John B Tyburski; William F Blakely; Frank J Gonzalez; Jeffrey R Idle
Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics.
Radiation research 2012;178(4):328-40.
2012: Caroline H Johnson; Dong Wook Kang; Jung-Hwan Kim; Kristopher W Krausz; Hans Luecke; Andrew D Patterson; Ondrej Slanar; Frank J Gonzalez; Jeffrey R Idle
Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics.
The American journal of clinical nutrition 2012;96(4):818-30.
2012: Jie Cheng; Kristopher W Krausz; Naoki Tanaka; Frank J Gonzalez
Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.
Toxicological sciences : an official journal of the Society of Toxicology 2012;129(2):456-68.
2012: Fei Li; Andrew D Patterson; Naoki Tanaka; Kristopher W Krausz; Frank J Gonzalez
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.
Journal of lipid research 2012;53(8):1625-35.
2012: Caroline H Johnson; Frank J Gonzalez
Challenges and opportunities of metabolomics.
Journal of cellular physiology 2012;227(8):2975-81.
2012: Andrew D Patterson; Yatrik M Shah; Kristopher W Krausz; Tsutomu Matsubara; Frank J Gonzalez
Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.
Hepatology (Baltimore, Md.) 2012;56(1):281-90.
2012: Naoki Tanaka; Kristopher W Krausz; Tsutomu Matsubara; Andrew D Patterson; Frank J Gonzalez
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2012;56(1):118-29.
2012: Jie Cheng; Yatrik M Shah; Frank J Gonzalez
Pregnane X receptor as a target for treatment of inflammatory bowel disorders.
Trends in pharmacological sciences 2012;33(6):323-30.
2012: Fei Li; Andrew D Patterson; Kristopher W Krausz; Bernhard Dick; Felix J Frey; Frank J Gonzalez; Jeffrey R Idle
Metabolomics reveals the metabolic map of procainamide in humans and mice.
Biochemical pharmacology 2012;83(10):1435-44.
2012: Xiang Xue; Ellen M Zimmermann; Matthew Taylor; Erik Anderson; Frank J Gonzalez; Joel K Greenson; Cathy Hao; Aijuan Qu; Yatrik M Shah
Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis.
Cancer research 2012;72(9):2285-93.
2012: Jessica A Bonzo; Christina H Ferry; Jung-Hwan Kim; Tsutomu Matsubara; Frank J Gonzalez
Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice.
The Journal of biological chemistry 2012;287(10):7345-56.
2012: Xiao-Yan Pang; Jie Cheng; Jung-Hwan Kim; Kristopher W Krausz; Tsutomu Matsubara; Frank J Gonzalez
Expression and regulation of human fetal-specific CYP3A7 in mice.
Endocrinology 2012;153(3):1453-63.
2012: Luis F Menezes; Andrew D Patterson; Klaus B Piontek; Fang Zhou; Frank J Gonzalez; Kristopher W Krausz; Gregory G Germino
Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.
PLoS genetics 2012;8(11):e1003053.
2011: Soumen K Manna; Andrew D Patterson; Qian Yang; Albert J Fornace; Jeffrey R Idle; Kristopher W Krausz; Frank J Gonzalez
UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model.
Journal of proteome research 2011;10(9):4120-33.
2011: Yuxia Zhang; Jessica A Bonzo; Frank J Gonzalez; L Wang
Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis.
The Journal of biological chemistry 2011;286(34):29635-43.
2011: Aijuan Qu; Matthew Taylor; Xiang Xue; Pierre Chambon; Frank J Gonzalez; Tsutomu Matsubara; Daniel Metzger; Yatrik M Shah
Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis.
Hepatology (Baltimore, Md.) 2011;54(2):472-83.
2011: Andrew D Patterson; Jessica A Bonzo; Fei Li; Kristopher W Krausz; Gabriel S Eichler; Sadaf Aslam; Xenia Tigno; John N Weinstein; Barbara C Hansen; Jeffrey R Idle; Frank J Gonzalez
Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus.
The Journal of biological chemistry 2011;286(22):19511-22.
2011: Laura Santangelo; Alessandra Marchetti; Claudia Cicchini; Alice Conigliaro; Beatrice Conti; Carmine Mancone; Jessica A Bonzo; Frank J Gonzalez; Tonino Alonzi; Laura Amicone; Marco Tripodi
The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α.
Hepatology (Baltimore, Md.) 2011;53(6):2063-74.
2011: Jie Cheng; Xiaochao Ma; Frank J Gonzalez
Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.
British journal of pharmacology 2011;163(3):461-8.
2011: Fei Li; Andrew D Patterson; Constance C Höfer; Kristopher W Krausz; Frank J Gonzalez; Jeffrey R Idle
A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics.
Biochemical pharmacology 2011;81(8):1043-53.
2011: Tsutomu Matsubara; Naoki Tanaka; Andrew D Patterson; Joo-Youn Cho; Kristopher W Krausz; Frank J Gonzalez
Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice.
Hepatology (Baltimore, Md.) 2011;53(4):1282-93.
2011: Caroline Johnson; Andrew D Patterson; Kristopher W Krausz; Christian Lanz; Dong Wook Kang; Hans Luecke; Frank J Gonzalez; Jeffrey R Idle
Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats.
Radiation research 2011;175(4):473-84.
2010: Jessica A Bonzo; Andrew D Patterson; Kristopher W Krausz; Frank J Gonzalez
Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo.
Molecular endocrinology (Baltimore, Md.) 2010;24(12):2343-55.
2010: Aijuan Qu; Yatrik M Shah; Tsutomu Matsubara; Qian Yang; Frank J Gonzalez
PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(2):404-10.
2010: Jie Cheng; Yatrik M Shah; Xiaochao Ma; Xiaoyan Pang; Toshiya Tanaka; Tatsuhiko Kodama; Kristopher W Krausz; Frank J Gonzalez
Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.
The Journal of pharmacology and experimental therapeutics 2010;335(1):32-41.
2010: Fei Li; Andrew D Patterson; Constance C Höfer; Kristopher W Krausz; Frank J Gonzalez; Jeffrey R Idle
Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.
Biochemical pharmacology 2010;80(7):1063-74.
2010: Soumen K Manna; Andrew D Patterson; Qian Yang; Kristopher W Krausz; Henghong Li; Jeffrey R Idle; Albert J Fornace; Frank J Gonzalez
Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse.
Journal of proteome research 2010;9(8):4176-88.
2010: Andrew D Patterson; Frank J Gonzalez; Jeffrey R Idle
Xenobiotic metabolism: a view through the metabolometer.
Chemical research in toxicology 2010;23(5):851-60.
2010: Joo-Youn Cho; Tsutomu Matsubara; Dong Wook Kang; Sung-Hoon Ahn; Kristopher W Krausz; Jeffrey R Idle; Hans Luecke; Frank J Gonzalez
Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge.
Journal of lipid research 2010;51(5):1063-74.
2010: Andrew D Patterson; Christian Lanz; Frank J Gonzalez; Jeffrey R Idle
The role of mass spectrometry-based metabolomics in medical countermeasures against radiation.
Mass spectrometry reviews 2010;29(3):503-21.
2010: Ting Wang; Yatrik M Shah; Tsutomu Matsubara; Yueying Zhen; Tomotaka Tanabe; Tomokazu Nagano; Serge Fotso; Kristopher W Krausz; T Mark Zabriskie; Jeffrey R Idle; Frank J Gonzalez
Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor alpha and role of the hypothalamic-pituitary-adrenal axis.
The Journal of biological chemistry 2010;285(10):7670-85.
2009: Andrew D Patterson; Ondrej Slanar; Kristopher W Krausz; Fei Li; Constance C Höfer; Frantisek Perlík; Frank J Gonzalez; Jeffrey R Idle
Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation.
Journal of proteome research 2009;8(9):4293-300.
2009: Jie Cheng; Xiaochao Ma; Kristopher W Krausz; Jeffrey R Idle; Frank J Gonzalez
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(8):1611-21.
2009: John B Tyburski; Andrew D Patterson; Kristopher W Krausz; Josef Slavík; Albert J Fornace; Frank J Gonzalez; Jeffrey R Idle
Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice.
Radiation research 2009;172(1):42-57.
2009: Xiaohui L Wang; Ryo Suzuki; Kevin Lee; Thien Tran; Jenny Gunton; Asish K Saha; Mary-Elizabeth Patti; Allison B Goldfine; Neil B Ruderman; Frank J Gonzalez; C Ronald Kahn
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
Cell metabolism 2009;9(5):428-39.
2009: Joo-Youn Cho; Dong Wook Kang; Xiaochao Ma; Sung-Hoon Ahn; Kristopher W Krausz; Hans Luecke; Jeffrey R Idle; Frank J Gonzalez
Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation.
Journal of lipid research 2009;50(5):924-37.
2009: Chi Chen; Kristopher W Krausz; Yatrik M Shah; Jeffrey R Idle; Frank J Gonzalez
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
Chemical research in toxicology 2009;22(4):699-707.
2009: Masahiro Nomoto; Masaaki Miyata; Shanai Yin; Yasushi Kurata; Miki Shimada; Kouichi Yoshinari; Frank J Gonzalez; Kokichi Suzuki; Shigeki Shibasaki; Tohru Kurosawa; Yasushi Yamazoe
Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor.
Biological & pharmaceutical bulletin 2009;32(2):172-8.
2009: Yatrik M Shah; Tsutomu Matsubara; Shinji Ito; Sun-Hee Yim; Frank J Gonzalez
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency.
Cell metabolism 2009;9(2):152-64.
2009: Masaaki Miyata; Yoshiki Matsuda; Masahiro Nomoto; Yuki Takamatsu; Nozomi Sato; Mayumi Hamatsu; Paul A Dawson; Frank J Gonzalez; Yasushi Yamazoe
Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):338-44.
2008: Xiaochao Ma; Connie Cheung; Kristopher W Krausz; Yatrik M Shah; Ting Wang; Jeffrey R Idle; Frank J Gonzalez
A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(12):2506-12.
2008: Connie Cheung; Frank J Gonzalez
Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment.
The Journal of pharmacology and experimental therapeutics 2008;327(2):288-99.
2008: Sung-Hoon Ahn; Yatrik M Shah; Junko Inoue; Keiichirou Morimura; Insook Kim; Sunhee Yim; Gilles Lambert; Reiko Kurotani; Kunio Nagashima; Frank J Gonzalez; Yusuke Inoue
Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease.
Inflammatory bowel diseases 2008;14(7):908-20.
2008: Yatrik M Shah; Shinji Ito; Keiichirou Morimura; Chi Chen; Sun Hee Yim; Volker H Haase; Frank J Gonzalez
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.
Gastroenterology 2008;134(7):2036-48, 2048.e1-3.
2008: Nicola F Smith; Sharyn D Baker; Frank J Gonzalez; J W Harris; William D Figg; Alex Sparreboom
Modulation of erlotinib pharmacokinetics in mice by a novel cytochrome P450 3A4 inhibitor, BAS 100.
British journal of cancer 2008;98(10):1630-2.
2008: Frank J Gonzalez; Yatrik M Shah
PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.
Toxicology 2008;246(1):2-8.
2008: Kimihiko Matsusue; Takashi Kusakabe; Takahiro Noguchi; Shouichi Takiguchi; Toshimitsu Suzuki; Shigeru Yamano; Frank J Gonzalez
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.
Cell metabolism 2008;7(4):302-11.
2008: Xiaochao Ma; Chi Chen; Kristopher W Krausz; Jeffrey R Idle; Frank J Gonzalez
A metabolomic perspective of melatonin metabolism in the mouse.
Endocrinology 2008;149(4):1869-79.
2008: Chi Chen; Kristopher W Krausz; Jeffrey R Idle; Frank J Gonzalez
Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice.
The Journal of biological chemistry 2008;283(8):4543-59.
2008: Chi Chen; Yatrik M Shah; Keiichirou Morimura; Kristopher W Krausz; Makoto Miyazaki; Terrilyn A Richardson; Edward T Morgan; James M Ntambi; Jeffrey R Idle; Frank J Gonzalez
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis.
Cell metabolism 2008;7(2):135-47.
2008: Andrew D Patterson; Henghong Li; Gabriel S Eichler; Kristopher W Krausz; John N Weinstein; Albert J Fornace; Frank J Gonzalez; Jeffrey R Idle
UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation.
Analytical chemistry 2008;80(3):665-74.
2008: Ting Wang; Xiaochao Ma; Kristopher W Krausz; Jeffrey R Idle; Frank J Gonzalez
Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.
The Journal of pharmacology and experimental therapeutics 2008;324(2):674-84.
2008: Frank J Gonzalez
Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription.
Drug metabolism and pharmacokinetics 2008;23(1):2-7.
2008: Qian Yang; Tomokazu Nagano; Yatrik M Shah; Connie Cheung; Shinji Ito; Frank J Gonzalez
The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.
Toxicological sciences : an official journal of the Society of Toxicology 2008;101(1):132-9.
2007: Insook Kim; Sung-Hoon Ahn; Takeshi Inagaki; Mihwa Choi; Shinji Ito; Grace L Guo; Steven A Kliewer; Frank J Gonzalez
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine.
Journal of lipid research 2007;48(12):2664-72.
2007: Masahiro Nomoto; Masaaki Miyata; Miki Shimada; Kouichi Yoshinari; Frank J Gonzalez; Shigeki Shibasaki; Tohru Kurosawa; Yasuhiro Shindo; Yasushi Yamazoe
ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output.
European journal of pharmacology 2007;574(2-3):192-200.
2007: Yueying Zhen; Kristopher W Krausz; Chi Chen; Jeffrey R Idle; Frank J Gonzalez
Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2136-51.
2007: Shinji Ito; Chi Chen; Junko Satoh; Sunhee Yim; Frank J Gonzalez
Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut.
The Journal of clinical investigation 2007;117(7):1940-50.
2007: Xiaochao Ma; Yatrik M Shah; Grace L Guo; Ting Wang; Kristopher W Krausz; Jeffrey R Idle; Frank J Gonzalez
Rifaximin is a gut-specific human pregnane X receptor activator.
The Journal of pharmacology and experimental therapeutics 2007;322(1):391-8.
2007: Frank J Gonzalez
Animal models for human risk assessment: the peroxisome proliferator-activated receptor alpha-humanized mouse.
Nutrition reviews 2007;65(6 Pt 2):S2-6.
2007: Yatrik M Shah; Keiichirou Morimura; Qian Yang; Tomotaka Tanabe; Mitsuhiro Takagi; Frank J Gonzalez
Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation.
Molecular and cellular biology 2007;27(12):4238-47.
2007: Qian Yang; Shinji Ito; Frank J Gonzalez
Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis.
Carcinogenesis 2007;28(6):1171-7.
2007: Insook Kim; Keiichirou Morimura; Yatrik M Shah; Qian Yang; Jerrold M Ward; Frank J Gonzalez
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice.
Carcinogenesis 2007;28(5):940-6.
2007: Yatrik M Shah; Xiaochao Ma; Keiichirou Morimura; Insook Kim; Frank J Gonzalez
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(4):G1114-22.
2007: Chi Chen; Xiaochao Ma; Michael A Malfatti; Kristopher W Krausz; Shioko Kimura; James S Felton; Jeffrey R Idle; Frank J Gonzalez
A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.
Chemical research in toxicology 2007;20(3):531-42.
2007: Xiaochao Ma; Jeffrey R Idle; Michael A Malfatti; Kristopher W Krausz; Daniel W Nebert; Chong-Sheng Chen; James S Felton; David J Waxman; Frank J Gonzalez
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis 2007;28(3):732-7.
2007: Sarbani Giri; Kristopher W Krausz; Jeffrey R Idle; Frank J Gonzalez
The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases.
Biochemical pharmacology 2007;73(4):561-73.
2007: Yatrik M Shah; Keiichirou Morimura; Frank J Gonzalez
Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(2):G657-66.
2007: Xiaochao Ma; Yatrik M Shah; Connie Cheung; Grace L Guo; Lionel Feigenbaum; Kristopher W Krausz; Jeffrey R Idle; Frank J Gonzalez
The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(2):194-200.
2007: Frank J Gonzalez
CYP3A4 and pregnane X receptor humanized mice.
Journal of biochemical and molecular toxicology 2007;21(4):158-62.
2007: Chi Chen; Frank J Gonzalez; Jeffrey R Idle
LC-MS-based metabolomics in drug metabolism.
Drug metabolism reviews 2007;39(2-3):581-97.
2007: Frank J Gonzalez
The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(1):1-8.
2006: Grace L Guo; Silvia Santamarina-Fojo; Taro E Akiyama; Marcelo J A Amar; Beverly Paigen; Bryan Brewer; Frank J Gonzalez
Effects of FXR in foam-cell formation and atherosclerosis development.
Biochimica et biophysica acta 2006;1761(12):1401-9.
2006: Ling-Hua Meng; Uma Shankavaram; Chi Chen; Keli Agama; Hai-qing Fu; Frank J Gonzalez; John Weinstein; Yves Pommier
Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.
Cancer research 2006;66(19):9656-64.
2006: Qian Yang; Reiko Kurotani; Atsushi Yamada; Shioko Kimura; Frank J Gonzalez
Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice.
Endocrinology 2006;147(10):4772-80.
2006: Mariko Shin; Insook Kim; Yusuke Inoue; Shioko Kimura; Frank J Gonzalez
Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.
Molecular pharmacology 2006;70(4):1281-90.
2006: Sun Hee Yim; Yatrik M Shah; Shuhei Tomita; H Douglas Morris; Oksana Gavrilova; Gilles Lambert; Jerrold M Ward; Frank J Gonzalez
Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice.
Hepatology (Baltimore, Md.) 2006;44(3):550-60.
2006: Yueying Zhen; Ondrej Slanar; Kristopher W Krausz; Chi Chen; Josef Slavík; Kerry L McPhail; T Mark Zabriskie; Frantisek Perlík; Frank J Gonzalez; Jeffrey R Idle
3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1563-74.
2006: Chi Chen; Linghua Meng; Xiaochao Ma; Kristopher W Krausz; Yves Pommier; Jeffrey R Idle; Frank J Gonzalez
Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).
The Journal of pharmacology and experimental therapeutics 2006;318(3):1330-42.
2006: Kimihiko Matsusue; Aya Miyoshi; Shigeru Yamano; Frank J Gonzalez
Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR.
Molecular and cellular endocrinology 2006;256(1-2):23-33.
2006: Masaaki Miyata; Yoshiki Matsuda; Hiroyuki Tsuchiya; Hirotaka Kitada; Takanori Akase; Miki Shimada; Kiyoshi Nagata; Frank J Gonzalez; Yasushi Yamazoe
Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.
Drug metabolism and pharmacokinetics 2006;21(4):315-23.
2006: M Adachi; Reiko Kurotani; Keiichirou Morimura; Yatrik M Shah; M Sanford; Blair B Madison; Deborah L Gumucio; H E Marin; Jeffrey M Peters; Howard A Young; Frank J Gonzalez
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease.
Gut 2006;55(8):1104-13.
2006: Masaaki Miyata; H Watase; W Hori; Miki Shimada; Kiyoshi Nagata; Frank J Gonzalez; Yasushi Yamazoe
Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(7):631-44.
2006: Sarbani Giri; Jeffrey R Idle; Chi Chen; T Mark Zabriskie; Kristopher W Krausz; Frank J Gonzalez
A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse.
Chemical research in toxicology 2006;19(6):818-27.
2006: Rika Ueda; Hiromi Iketaki; Kiyoshi Nagata; Shioko Kimura; Frank J Gonzalez; Kazutomi Kusano; Tsutomu Yoshimura; Yasushi Yamazoe
A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes.
Molecular pharmacology 2006;69(6):1924-30.
2006: Xiaochao Ma; Jeffrey R Idle; Kristopher W Krausz; Dun-Xian Tan; Leopoldo Ceraulo; Frank J Gonzalez
Urinary metabolites and antioxidant products of exogenous melatonin in the mouse.
Journal of pineal research 2006;40(4):343-9.
2006: Keiichirou Morimura; Connie Cheung; Jerrold M Ward; Janardan K Reddy; Frank J Gonzalez
Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.
Carcinogenesis 2006;27(5):1074-80.
2006: Yusuke Inoue; Luanne L Peters; Sun Hee Yim; Junko Inoue; Frank J Gonzalez
Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression.
Journal of molecular medicine (Berlin, Germany) 2006;84(4):334-44.
2006: Frank J Gonzalez
Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stress.
The Biochemical journal 2006;394(Pt 2):e3-5.
2006: Connie Cheung; Ai-Ming Yu; Chong-Sheng Chen; Kristopher W Krausz; Linda G Byrd; Lionel Feigenbaum; Robert J Edwards; David J Waxman; Frank J Gonzalez
Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1328-34.
2006: Qian Yang; Atsushi Yamada; Shioko Kimura; Jeffrey M Peters; Frank J Gonzalez
Alterations in skin and stratified epithelia by constitutively activated PPARalpha.
The Journal of investigative dermatology 2006;126(2):374-85.
2006: Hyunghee Lee; Frank J Gonzalez; Michung Yoon
Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha.
Biochemical and biophysical research communications 2006;339(1):196-203.
2006: Frank J Gonzalez; Ai-Ming Yu
Cytochrome P450 and xenobiotic receptor humanized mice.
Annual review of pharmacology and toxicology 2006;46():41-64.
2006: Yusuke Inoue; Ai-Ming Yu; Sun Hee Yim; Xiaochao Ma; Kristopher W Krausz; Junko Inoue; Charlie C Xiang; Michael J Brownstein; Gösta Eggertsen; Ingemar Björkhem; Frank J Gonzalez
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha.
Journal of lipid research 2006;47(1):215-27.
2005: Connie Cheung; Xiaochao Ma; Kristopher W Krausz; Shioko Kimura; Lionel Feigenbaum; Timothy P Dalton; Daniel W Nebert; Jeffrey R Idle; Frank J Gonzalez
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.
Chemical research in toxicology 2005;18(9):1471-8.
2005: Ai-Ming Yu; Katsumi Fukamachi; Kristopher W Krausz; Connie Cheung; Frank J Gonzalez
Potential role for human cytochrome P450 3A4 in estradiol homeostasis.
Endocrinology 2005;146(7):2911-9.
2005: Christopher J Nicol; Masahiro Adachi; Taro E Akiyama; Frank J Gonzalez
PPARgamma in endothelial cells influences high fat diet-induced hypertension.
American journal of hypertension 2005;18(4 Pt 1):549-56.
2005: Xiaochao Ma; Jeffrey R Idle; Kristopher W Krausz; Frank J Gonzalez
Metabolism of melatonin by human cytochromes p450.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(4):489-94.
2005: Connie Cheung; Ai-Ming Yu; Jerrold M Ward; Kristopher W Krausz; Taro E Akiyama; Lionel Feigenbaum; Frank J Gonzalez
The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(3):449-57.
2005: Frank J Gonzalez
Getting fat: two new players in molecular adipogenesis.
Cell metabolism 2005;1(2):85-6.
2005: Masaaki Miyata; Aki Tozawa; Hijiri Otsuka; Toshifumi Nakamura; Kiyoshi Nagata; Frank J Gonzalez; Yasushi Yamazoe
Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity.
The Journal of pharmacology and experimental therapeutics 2005;312(2):759-66.
2005: Frank J Gonzalez
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
Mutation research 2005;569(1-2):101-10.
2004: Akihide Kamiya; Yusuke Inoue; Tatsuhiko Kodama; Frank J Gonzalez
Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver.
FEBS letters 2004;578(1-2):63-8.
2004: Qian Yang; Frank J Gonzalez
Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice.
Biochemical pharmacology 2004;68(11):2143-50.
2004: Grace L Guo; Jeff S Moffit; Christopher J Nicol; Jerrold M Ward; Lauren A Aleksunes; Angela L Slitt; Steven A Kliewer; José E Manautou; Frank J Gonzalez
Enhanced acetaminophen toxicity by activation of the pregnane X receptor.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(2):374-80.
2004: Kimihiko Matsusue; Oksana Gavrilova; Gilles Lambert; H Bryan Brewer; Jerrold M Ward; Yusuke Inoue; Derek LeRoith; Frank J Gonzalez
Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.
Molecular endocrinology (Baltimore, Md.) 2004;18(11):2751-64.
2004: Yusuke Inoue; Junko Inoue; Gilles Lambert; Sun Hee Yim; Frank J Gonzalez
Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.
The Journal of biological chemistry 2004;279(43):44740-8.
2004: Akihide Kamiya; Frank J Gonzalez
TNF-alpha regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices.
Hepatology (Baltimore, Md.) 2004;40(3):527-36.
2004: Kimihiko Matsusue; Jeffrey M Peters; Frank J Gonzalez
PPARbeta/delta potentiates PPARgamma-stimulated adipocyte differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1477-9.
2004: Christopher J Nicol; Michung Yoon; Jerrold M Ward; Masamichi Yamashita; Katsumi Fukamachi; Jeffrey M Peters; Frank J Gonzalez
PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis.
Carcinogenesis 2004;25(9):1747-55.
2004: Connie Cheung; Taro E Akiyama; Jerrold M Ward; Christopher J Nicol; Lionel Feigenbaum; Charles Vinson; Frank J Gonzalez
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
Cancer research 2004;64(11):3849-54.
2004: Taro E Akiyama; Gilles Lambert; Christopher J Nicol; Kimihiko Matsusue; Jeffrey M Peters; H Bryan Brewer; Frank J Gonzalez
Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet.
The Journal of biological chemistry 2004;279(20):20874-81.
2004: Frank J Gonzalez
Cytochrome P450 humanised mice.
Human genomics 2004;1(4):300-6.
2004: Ai-Ming Yu; Jeffrey R Idle; Frank J Gonzalez
Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.
Drug metabolism reviews 2004;36(2):243-77.
2004: Fausto Andreola; Graham P Hayhurst; Gang Luo; Stephen S Ferguson; Frank J Gonzalez; Joyce A Goldstein; LUIGI DE LUCA
Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice.
The Journal of biological chemistry 2004;279(5):3434-8.
2004: Yusuke Inoue; Ai-Ming Yu; Junko Inoue; Frank J Gonzalez
Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation.
The Journal of biological chemistry 2004;279(4):2480-9.
2004: Fausto Andreola; Diego F Calvisi; Guillermo Elizondo; Sonia B Jakowlew; Jennifer Mariano; Frank J Gonzalez; LUIGI DE LUCA
Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion.
Hepatology (Baltimore, Md.) 2004;39(1):157-66.
2003: Connie Cheung; Taro E Akiyama; Gen Kudo; Frank J Gonzalez
Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice.
Biochemical pharmacology 2003;66(10):2011-20.
2003: Grace L Guo; Gilles Lambert; Masahiko Negishi; Jerrold M Ward; H Bryan Brewer; Steven A Kliewer; Frank J Gonzalez; Christopher J Sinal
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.
The Journal of biological chemistry 2003;278(46):45062-71.
2003: Frank J Gonzalez
Role of gene knockout and transgenic mice in the study of xenobiotic metabolism.
Drug metabolism reviews 2003;35(4):319-35.
2003: Oksana Gavrilova; Martin Haluzik; Kimihiko Matsusue; Jaime J Cutson; Lisa Johnson; Kelly R Dietz; Christopher J Nicol; Charles Vinson; Frank J Gonzalez; Marc L Reitman
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.
The Journal of biological chemistry 2003;278(36):34268-76.
2003: Ming Hu; Kristopher W Krausz; Jun Chen; Xia Ge; Jianqi Li; Harry L Gelboin; Frank J Gonzalez
Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(7):924-31.
2003: Ai-Ming Yu; Jeffrey R Idle; Tomas Herraiz; Adrian Küpfer; Frank J Gonzalez
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.
Pharmacogenetics 2003;13(6):307-19.
2003: Akihide Kamiya; Yusuke Inoue; Frank J Gonzalez
Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development.
Hepatology (Baltimore, Md.) 2003;37(6):1375-84.
2003: Hirotaka Kitada; Masaaki Miyata; Toshifumi Nakamura; Aki Tozawa; Wataru Honma; Miki Shimada; Kiyoshi Nagata; Christopher J Sinal; Grace L Guo; Frank J Gonzalez; Yasushi Yamazoe
Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.
The Journal of biological chemistry 2003;278(20):17838-44.
2003: Sun Hee Yim; Jerrold M Ward; Yvonne P Dragan; Atsushi Yamada; Peter C Scacheri; Shioko Kimura; Frank J Gonzalez
Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles.
Toxicologic pathology 2003;31(3):295-303.
2003: Camille P Granvil; Ai-Ming Yu; Guillermo Elizondo; Taro E Akiyama; Connie Cheung; Lionel Feigenbaum; Kristopher W Krausz; Frank J Gonzalez
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):548-58.
2003: Ai-Ming Yu; Jeffrey R Idle; Kristopher W Krausz; Adrian Küpfer; Frank J Gonzalez
Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.
The Journal of pharmacology and experimental therapeutics 2003;305(1):315-22.
2003: Shioko Kimura; Mayumi Kawabe; Aiming Yu; Hideki Morishima; Pedro Fernandez-Salguero; George J Hammons; Jerrold M Ward; Fred F Kadlubar; Frank J Gonzalez
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.
Carcinogenesis 2003;24(3):583-7.
2003: Ai-Ming Yu; Jeffrey R Idle; Linda G Byrd; Kristopher W Krausz; Adrian Küpfer; Frank J Gonzalez
Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.
Pharmacogenetics 2003;13(3):173-81.
2003: Kimihiko Matsusue; Martin Haluzik; Gilles Lambert; Sun Hee Yim; Oksana Gavrilova; Jerrold M Ward; Bryan Brewer; Marc L Reitman; Frank J Gonzalez
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes.
The Journal of clinical investigation 2003;111(5):737-47.
2003: Taro E Akiyama; Frank J Gonzalez
Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors.
Biochimica et biophysica acta 2003;1619(3):223-34.
2003: Ai-Ming Yu; Camille P Granvil; Robert L Haining; Kristopher W Krausz; Javier Corchero; Adrian Küpfer; Jeffrey R Idle; Frank J Gonzalez
The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine.
The Journal of pharmacology and experimental therapeutics 2003;304(2):539-46.
2003: Frank J Gonzalez; Shioko Kimura
Study of P450 function using gene knockout and transgenic mice.
Archives of biochemistry and biophysics 2003;409(1):153-8.
2002: Frank J Gonzalez
Transgenic models in xenobiotic metabolism and toxicology.
Toxicology 2002;181-182():237-9.
2002: Frank J Gonzalez
The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis.
Molecular and cellular endocrinology 2002;193(1-2):71-9.
2002: Yusuke Inoue; Graham P Hayhurst; Junko Inoue; Masataka Mori; Frank J Gonzalez
Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo.
The Journal of biological chemistry 2002;277(28):25257-65.
2002: Camille P Granvil; Kristopher W Krausz; Harry V Gelboin; Jeffrey R Idle; Frank J Gonzalez
4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1025-32.
2002: Taro E Akiyama; Christopher T Baumann; Shuichi Sakai; Gordon L Hager; Frank J Gonzalez
Selective intranuclear redistribution of PPAR isoforms by RXR alpha.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):707-21.
2002: Taro E Akiyama; Shuichi Sakai; Gilles Lambert; Christopher J Nicol; Kimihiko Matsusue; Satish Pimprale; Ying-Hue Lee; Mercedes Ricote; Christopher K Glass; H Bryan Brewer; Frank J Gonzalez
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.
Molecular and cellular biology 2002;22(8):2607-19.
2002: Masaaki Miyata; Kazuko Motoki; Etsuko Tamura; Masayuki Furukawa; Frank J Gonzalez; Yasushi Yamazoe
Relative importance of maternal and embryonic microsomal epoxide hydrolase in 7,12-dimethylbenz[a]anthracene-induced developmental toxicity.
Biochemical pharmacology 2002;63(6):1077-84.
2002: Fabienne Le Provost; Gregory Riedlinger; Sun Hee Yim; Jamie Benedict; Frank J Gonzalez; Jodi A Flaws; Lothar Hennighausen
The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility.
Genesis (New York, N.Y. : 2000) 2002;32(3):231-9.
2001: Christopher J Sinal; M Yoon; Frank J Gonzalez
Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids.
The Journal of biological chemistry 2001;276(50):47154-62.
2001: Javier Corchero; Camille P Granvil; Taro E Akiyama; Graham P Hayhurst; Satish Pimprale; Lionel Feigenbaum; Jeffrey R Idle; Frank J Gonzalez
The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.
Molecular pharmacology 2001;60(6):1260-7.
2001: Kristopher W Krausz; I Goldfarb; Jeroen Buters; TJ Yang; Frank J Gonzalez; Harry V Gelboin
Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1410-23.
2001: Taro E Akiyama; Christopher J Nicol; Catherine Fievet; Bart Staels; Jerrold M Ward; Johan Auwerx; S S Lee; Frank J Gonzalez; Jeffrey M Peters
Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.
The Journal of biological chemistry 2001;276(42):39088-93.
2001: Masaaki Miyata; Masayuki Furukawa; K Takahashi; Frank J Gonzalez; Yasushi Yamazoe
Mechanism of 7,12-dimethylbenz[a]anthracene-induced immunotoxicity: role of metabolic activation at the target organ.
Japanese journal of pharmacology 2001;86(3):302-9.
2001: Frank J Gonzalez; Shioko Kimura
Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice.
Mutation research 2001;477(1-2):79-87.
2001: A Kiss; R Ortiz-Aguayo; Richard Sharp; Glenn Merlino; Snorri S Thorgeirsson; Frank J Gonzalez; Jeffrey M Peters
Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation.
Carcinogenesis 2001;22(6):975-9.
2001: Frank J Gonzalez
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis.
Toxicology letters 2001;120(1-3):199-208.
2001: Javier Corchero; Satish Pimprale; Shioko Kimura; Frank J Gonzalez
Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.
Pharmacogenetics 2001;11(1):1-6.
2001: Graham P Hayhurst; Ying-Hue Lee; Gilles Lambert; Jerrold M Ward; Frank J Gonzalez
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.
Molecular and cellular biology 2001;21(4):1393-403.
2000: Christopher J Sinal; M Miyata; Masahiro Tohkin; K Nagata; John R Bend; Frank J Gonzalez
Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation.
The Journal of biological chemistry 2000;275(51):40504-10.
2000: Guillermo Elizondo; Javier Corchero; Esta Sterneck; Frank J Gonzalez
Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor alpha and CCAAT/enhancer-binding protein beta.
The Journal of biological chemistry 2000;275(50):39747-53.
2000: KJ Aitchison; Frank J Gonzalez; L C Quattrochi; A Sapone; J H Zhao; H Zaher; Guillermo Elizondo; C Bryant; Janet Munro; David A Collier; A I Makoffa; Robert W Kerwin
Identification of novel polymorphisms in the 5' flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance.
Pharmacogenetics 2000;10(8):695-704.
2000: Shuhei Tomita; Christopher J Sinal; Sun Hee Yim; Frank J Gonzalez
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha.
Molecular endocrinology (Baltimore, Md.) 2000;14(10):1674-81.
2000: Masahiro Tohkin; M Fukuhara; Guillermo Elizondo; Shuhei Tomita; Frank J Gonzalez
Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1A.
Molecular pharmacology 2000;58(4):845-51.
2000: Christopher J Sinal; Masahiro Tohkin; M Miyata; J M Ward; G Lambert; Frank J Gonzalez
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.
Cell 2000;102(6):731-44.
2000: T Ueno; S Tamura; W I Frels; Magang Shou; Frank J Gonzalez; Shioko Kimura
A transgenic mouse expressing human CYP1A2 in the pancreas.
Biochemical pharmacology 2000;60(6):857-63.
2000: Taro E Akiyama; Jerrold M Ward; Frank J Gonzalez
Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice.
The Journal of biological chemistry 2000;275(35):27117-22.
2000: J M Peters; S S Lee; Weiqun Li; Jerrold M Ward; Oksana Gavrilova; C Everett; Marc L Reitman; L D Hudson; Frank J Gonzalez
Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta).
Molecular and cellular biology 2000;20(14):5119-28.
2000: Kristopher W Krausz; I Goldfarb; TJ Yang; Frank J Gonzalez; Harry V Gelboin
An inhibitory monoclonal antibody to human cytochrome P450 that specifically binds and inhibits P4502C9II, an allelic variant of P4502C9 having a single amino acid change Arg144 Cys.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(6):619-25.
2000: A Sapone; J M Peters; S Sakai; S Tomita; S S Papiha; R Dai; Fred Friedman; Frank J Gonzalez
The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.
Pharmacogenetics 2000;10(4):321-33.
2000: Guillermo Elizondo; Pedro Fernandez-Salguero; M S Sheikh; G Y Kim; Albert J Fornace; Kyung S Lee; Frank J Gonzalez
Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast.
Molecular pharmacology 2000;57(5):1056-63.
2000: Y Sai; R Dai; TJ Yang; Kristopher W Krausz; Frank J Gonzalez; Harry V Gelboin; Magang Shou
Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(4):327-43.
2000: Jeffrey M Peters; Ivan Rusyn; M L Rose; Frank J Gonzalez; R G Thurman
Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.
Carcinogenesis 2000;21(4):823-6.
2000: KJ Aitchison; Michael W Jann; J H Zhao; T Sakai; H Zaher; Kim Wolff; David A Collier; Robert W Kerwin; Frank J Gonzalez
Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice.
Journal of psychopharmacology (Oxford, England) 2000;14(4):353-9.
2000: F Sata; A Sapone; Guillermo Elizondo; P Stocker; Vaughn P Miller; W Zheng; Hannu Raunio; Charles L Crespi; Frank J Gonzalez
CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.
Clinical pharmacology and therapeutics 2000;67(1):48-56.
1999: Harry V Gelboin; Kristopher W Krausz; Frank J Gonzalez; TJ Yang
Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discovery.
Trends in pharmacological sciences 1999;20(11):432-8.
1999: Frank J Gonzalez; S Kimura
Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis.
Cancer letters 1999;143(2):199-204.
1999: Shioko Kimura; M Kawabe; Jerrold M Ward; Hideki Morishima; Fred F Kadlubar; George J Hammons; Pedro Fernandez-Salguero; Frank J Gonzalez
CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice.
Carcinogenesis 1999;20(9):1825-30.
1999: M Miyata; G Kudo; Y H Lee; TJ Yang; Harry V Gelboin; Pedro Fernandez-Salguero; Shioko Kimura; Frank J Gonzalez
Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene.
The Journal of biological chemistry 1999;274(34):23963-8.
1999: J M Peters; Hideki Morishima; Jerrold M Ward; C J Coakley; Shioko Kimura; Frank J Gonzalez
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
Toxicological sciences : an official journal of the Society of Toxicology 1999;50(1):82-9.
1999: Y Sai; TJ Yang; Kristopher W Krausz; Frank J Gonzalez; Harry V Gelboin
An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver.
Pharmacogenetics 1999;9(2):229-37.
1999: Jeroen Buters; S Sakai; T Richter; T Pineau; David L Alexander; U Savas; Johannes Doehmer; Jerrold M Ward; Colin R Jefcoate; Frank J Gonzalez
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1977-82.
1999: J M Peters; Michael G Narotsky; Guillermo Elizondo; Pedro Fernandez-Salguero; Frank J Gonzalez; Barbara D Abbott
Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice.
Toxicological sciences : an official journal of the Society of Toxicology 1999;47(1):86-92.
1999: TJ Yang; Kristopher W Krausz; Y Sai; Frank J Gonzalez; Harry V Gelboin
Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(1):102-9.
1998: Frank J Gonzalez
The study of xenobiotic-metabolizing enzymes and their role in toxicity in vivo using targeted gene disruption.
Toxicology letters 1998;102-103():161-6.
1998: howard mcleod; Elaina Collie-Duguid; P Vreken; Martin R Johnson; X Wei; A Sapone; R B Diasio; Pedro Fernandez-Salguero; A B van Kuilenberg; A H van Gennip; Frank J Gonzalez
Nomenclature for human DPYD alleles.
Pharmacogenetics 1998;8(6):455-9.
1998: Frank J Gonzalez; Pedro Fernandez-Salguero
The aryl hydrocarbon receptor: studies using the AHR-null mice.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(12):1194-8.
1998: Frank J Gonzalez; Jeffrey M Peters; RC Cattley
Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.
Journal of the National Cancer Institute 1998;90(22):1702-9.
1998: Jeffrey M Peters; T Aoyama; RC Cattley; U Nobumitsu; T Hashimoto; Frank J Gonzalez
Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.
Carcinogenesis 1998;19(11):1989-94.
1998: Magang Shou; M Martinet; Kenneth R Korzekwa; Kristopher W Krausz; Frank J Gonzalez; Harry V Gelboin
Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver.
Pharmacogenetics 1998;8(5):391-401.
1998: TJ Yang; Y Sai; Kristopher W Krausz; Frank J Gonzalez; Harry V Gelboin
Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver.
Pharmacogenetics 1998;8(5):375-82.
1998: H Zaher; Jeroen Buters; Jerrold M Ward; Mary K Bruno; A M Lucas; Stephan T Stern; Steven D Cohen; Frank J Gonzalez
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
Toxicology and applied pharmacology 1998;152(1):193-9.
1998: Susan A Ridge; J Sludden; O Brown; L Robertson; X Wei; A Sapone; Pedro Fernandez-Salguero; Frank J Gonzalez; P Vreken; A B van Kuilenburg; A H van Gennip; howard mcleod
Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.
British journal of clinical pharmacology 1998;46(2):151-6.
1998: X Wei; Guillermo Elizondo; A Sapone; howard mcleod; Hannu Raunio; Pedro Fernandez-Salguero; Frank J Gonzalez
Characterization of the human dihydropyrimidine dehydrogenase gene.
Genomics 1998;51(3):391-400.
1998: H Zaher; Pedro Fernandez-Salguero; John J Letterio; M S Sheikh; Albert J Fornace; Anita B Roberts; Frank J Gonzalez
The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis.
Molecular pharmacology 1998;54(2):313-21.
1998: TJ Yang; Kristopher W Krausz; Magang Shou; S K Yang; Jeroen Buters; Frank J Gonzalez; Harry V Gelboin
Inhibitory monoclonal antibody to human cytochrome P450 2B6.
Biochemical pharmacology 1998;55(10):1633-40.
1998: Ying-Hue Lee; B Sauer; Frank J Gonzalez
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.
Molecular and cellular biology 1998;18(5):3059-68.
1998: TJ Yang; Magang Shou; Kenneth R Korzekwa; Frank J Gonzalez; Harry V Gelboin; S K Yang
Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam.
Biochemical pharmacology 1998;55(6):889-96.
1998: H Zaher; TJ Yang; Harry V Gelboin; Pedro Fernandez-Salguero; Frank J Gonzalez
Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse.
Biochemical pharmacology 1998;55(2):235-8.
1998: Susan A Ridge; J Sludden; X Wei; A Sapone; O Brown; S Hardy; P Canney; Pedro Fernandez-Salguero; Frank J Gonzalez; Jim Cassidy; howard mcleod
Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.
British journal of cancer 1998;77(3):497-500.
1997: Harry V Gelboin; Kristopher W Krausz; Magang Shou; Frank J Gonzalez; TJ Yang
A monoclonal antibody inhibitory to human P450 2D6: a paradigm for use in combinatorial determination of individual P450 role in specific drug tissue metabolism.
Pharmacogenetics 1997;7(6):469-77.
1997: Pedro Fernandez-Salguero; Jerrold M Ward; J P Sundberg; Frank J Gonzalez
Lesions of aryl-hydrocarbon receptor-deficient mice.
Veterinary pathology 1997;34(6):605-14.
1997: Jeffrey M Peters; RC Cattley; Frank J Gonzalez
Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.
Carcinogenesis 1997;18(11):2029-33.
1997: Jeffrey M Peters; Nathalie Hennuyer; Bart Staels; J C Fruchart; Catherine Fievet; Frank J Gonzalez; Johan Auwerx
Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice.
The Journal of biological chemistry 1997;272(43):27307-12.
1997: Ying-Hue Lee; B Sauer; Peter F Johnson; Frank J Gonzalez
Disruption of the c/ebp alpha gene in adult mouse liver.
Molecular and cellular biology 1997;17(10):6014-22.
1997: E L Code; Charles L Crespi; Bruce W Penman; Frank J Gonzalez; T K Chang; D J Waxman
Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(8):985-93.
1997: Fausto Andreola; Pedro Fernandez-Salguero; Maria V Chiantore; Martin Petkovich; Frank J Gonzalez; LUIGI DE LUCA
Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism.
Cancer research 1997;57(14):2835-8.
1997: Kristopher W Krausz; TJ Yang; Frank J Gonzalez; Magang Shou; Harry V Gelboin
Inhibitory monoclonal antibodies to human cytochrome P450 2D6.
Biochemical pharmacology 1997;54(1):15-7.
1997: Pedro Fernandez-Salguero; A Sapone; X Wei; J R Holt; S Jones; Jeffrey R Idle; Frank J Gonzalez
Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin.
Pharmacogenetics 1997;7(2):161-3.
1997: Ying-Hue Lee; Simon Williams; Mark Baer; Esta Sterneck; Frank J Gonzalez; Peter F Johnson
The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain.
Molecular and cellular biology 1997;17(4):2038-47.
1997: L Chen; Jeroen Buters; James P Hardwick; S Tamura; Bruce W Penman; Frank J Gonzalez; Charles L Crespi
Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(4):399-405.
1997: Frank J Gonzalez
Recent update on the PPAR alpha-null mouse.
Biochimie 1997;79(2-3):139-44.
1997: Frank J Gonzalez
The role of peroxisome proliferator activated receptor alpha in peroxisome proliferation, physiological homeostasis, and chemical carcinogenesis.
Advances in experimental medicine and biology 1997;422():109-25.
1997: Magang Shou; Kenneth R Korzekwa; E N Brooks; Kristopher W Krausz; Frank J Gonzalez; Harry V Gelboin
Role of human hepatic cytochrome P450 1A2 and 3A4 in the metabolic activation of estrone.
Carcinogenesis 1997;18(1):207-14.
1997: Susan A Ridge; O Brown; J McMurrough; Pedro Fernandez-Salguero; William Evans; Frank J Gonzalez; howard mcleod
Mutations at codon 974 of the DPYD gene are a rare event.
British journal of cancer 1997;75(2):178-9.
1996: S S Lee; Frank J Gonzalez
Targeted disruption of the peroxisome proliferator-activated receptor alpha gene, PPAR alpha.
Annals of the New York Academy of Sciences 1996;804():524-9.
1996: Magang Shou; Frank J Gonzalez; Harry V Gelboin
Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase.
Biochemistry 1996;35(49):15807-13.
1996: Frank J Gonzalez; Pedro Fernandez-Salguero; Jerrold M Ward
The role of the aryl hydrocarbon receptor in animal development, physiological homeostasis and toxicity of TCDD.
The Journal of toxicological sciences 1996;21(5):273-7.
1996: Magang Shou; Kenneth R Korzekwa; Kristopher W Krausz; Jeroen Buters; J Grogan; I Goldfarb; James P Hardwick; Frank J Gonzalez; Harry V Gelboin
Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene.
Molecular carcinogenesis 1996;17(4):241-9.
1996: Magang Shou; Kristopher W Krausz; Frank J Gonzalez; Harry V Gelboin
Metabolic activation of the potent carcinogen dibenzo[a,l]pyrene by human recombinant cytochromes P450, lung and liver microsomes.
Carcinogenesis 1996;17(11):2429-33.
1996: Harry V Gelboin; I Goldfarb; Kristopher W Krausz; J Grogan; Kenneth R Korzekwa; Frank J Gonzalez; Magang Shou
Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 2E1.
Chemical research in toxicology 1996;9(6):1023-30.
1996: Pedro Fernandez-Salguero; David M Hilbert; Stuart Rudikoff; Jerrold M Ward; Frank J Gonzalez
Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity.
Toxicology and applied pharmacology 1996;140(1):173-9.
1996: Thierry Pineau; W R Hudgins; L Liu; L C Chen; T Sher; Frank J Gonzalez; D Samid
Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs.
Biochemical pharmacology 1996;52(4):659-67.
1996: Jeroen Buters; B K Tang; Thierry Pineau; Harry V Gelboin; Shioko Kimura; Frank J Gonzalez
Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2.
Pharmacogenetics 1996;6(4):291-6.
1996: X Wei; howard mcleod; J McMurrough; Frank J Gonzalez; Pedro Fernandez-Salguero
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.
The Journal of clinical investigation 1996;98(3):610-5.
1996: J M Peters; Y C Zhou; P A Ram; S S Lee; Frank J Gonzalez; D J Waxman
Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.
Molecular pharmacology 1996;50(1):67-74.
1996: Frank J Gonzalez
Use of transgenic animals in carcinogenesis studies.
Molecular carcinogenesis 1996;16(2):63-7.
1996: S S Lee; Jeroen Buters; Thierry Pineau; Pedro Fernandez-Salguero; Frank J Gonzalez
Role of CYP2E1 in the hepatotoxicity of acetaminophen.
The Journal of biological chemistry 1996;271(20):12063-7.
1996: Magang Shou; Kristopher W Krausz; Frank J Gonzalez; Harry V Gelboin
Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450.
Archives of biochemistry and biophysics 1996;328(1):201-7.
1996: Pedro Fernandez-Salguero; Frank J Gonzalez
Targeted disruption of specific cytochromes P450 and xenobiotic receptor genes.
Methods in enzymology 1996;272():412-30.
1995: H Furuya; Pedro Fernandez-Salguero; W Gregory; H Taber; A Steward; Frank J Gonzalez; Jeffrey Idle
Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy.
Pharmacogenetics 1995;5(6):389-92.
1995: Frank J Gonzalez; Pedro Fernandez-Salguero; S S Lee; Thierry Pineau; Jerrold M Ward
Xenobiotic receptor knockout mice.
Toxicology letters 1995;82-83():117-21.
1995: Harry V Gelboin; Kristopher W Krausz; I Goldfarb; Jeroen Buters; S K Yang; Frank J Gonzalez; Kenneth R Korzekwa; Magang Shou
Inhibitory and non-inhibitory monoclonal antibodies to human cytochrome P450 3A3/4.
Biochemical pharmacology 1995;50(11):1841-50.
1995: J Grogan; Magang Shou; E A Andrusiak; S Tamura; Jeroen Buters; Frank J Gonzalez; Kenneth R Korzekwa
Cytochrome P450 2A1, 2E1, and 2C9 cDNA-expression by insect cells and partial purification using hydrophobic chromatography.
Biochemical pharmacology 1995;50(9):1509-15.
1995: Frank J Gonzalez; Pedro Fernandez-Salguero
Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency.
Trends in pharmacological sciences 1995;16(10):325-7.
1995: Pedro Fernandez-Salguero; Frank J Gonzalez; M C Etienne; G Milano; S Kimura
Correlation between catalytic activity and protein content for the polymorphically expressed dihydropyrimidine dehydrogenase in human lymphocytes.
Biochemical pharmacology 1995;50(7):1015-20.
1995: Jeroen Buters; Magang Shou; James P Hardwick; Kenneth R Korzekwa; Frank J Gonzalez
cDNA-directed expression of human cytochrome P450 CYP1A1 using baculovirus. Purification, dependency on NADPH-P450 oxidoreductase, and reconstitution of catalytic properties without purification.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(7):696-701.
1995: S S Lee; Thierry Pineau; J Drago; E J Lee; J W Owens; Deanna L Kroetz; Pedro Fernandez-Salguero; Heiner Westphal; Frank J Gonzalez
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Molecular and cellular biology 1995;15(6):3012-22.
1995: Thierry Pineau; Pedro Fernandez-Salguero; S S Lee; T McPhail; Jerrold M Ward; Frank J Gonzalez
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5134-8.
1995: Pedro Fernandez-Salguero; Thierry Pineau; David M Hilbert; T McPhail; S S Lee; Shioko Kimura; Daniel W Nebert; Stuart Rudikoff; Jerrold M Ward; Frank J Gonzalez
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.
Science (New York, N.Y.) 1995;268(5211):722-6.
1995: S Y Liu; Frank J Gonzalez
Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene.
DNA and cell biology 1995;14(4):285-93.
1995: Frank J Gonzalez
Genetic polymorphism and cancer susceptibility: fourteenth Sapporo Cancer Seminar.
Cancer research 1995;55(3):710-5.
1995: Rutger Meinsma; Pedro Fernandez-Salguero; André B P van Kuilenburg; Albert H van Gennip; Frank J Gonzalez
Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.
DNA and cell biology 1995;14(1):1-6.
1995: Pedro Fernandez-Salguero; Frank J Gonzalez
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.
Pharmacogenetics 1995;5 Spec No():S123-8.
1994: Laurie L Herscher; Murali K Cherukuri; John A Cook; C Norman Coleman; J E Biaglow; S W Tuttle; Frank J Gonzalez; James B Mitchell
Protection against SR 4233 (Tirapazamine) aerobic cytotoxicity by the metal chelators desferrioxamine and tiron.
International journal of radiation oncology, biology, physics 1994;30(4):879-85.
1994: H Yokota; Pedro Fernandez-Salguero; H Furuya; K Lin; O W McBride; B Podschun; Klaus D Schnackerz; Frank J Gonzalez
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
The Journal of biological chemistry 1994;269(37):23192-6.
1994: Jeroen Buters; Kenneth R Korzekwa; Kent L Kunze; Y Omata; James P Hardwick; Frank J Gonzalez
cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirus.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(5):688-92.
1994: Magang Shou; Kenneth R Korzekwa; Kristopher W Krausz; C L Crespi; Frank J Gonzalez; Harry V Gelboin
Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450.
Cancer letters 1994;83(1-2):305-13.
1994: Magang Shou; Kenneth R Korzekwa; C L Crespi; Frank J Gonzalez; Harry V Gelboin
The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol.
Molecular carcinogenesis 1994;10(3):159-68.
1994: T K Chang; Frank J Gonzalez; D J Waxman
Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.
Archives of biochemistry and biophysics 1994;311(2):437-42.
1994: Magang Shou; J Grogan; J A Mancewicz; Kristopher W Krausz; Frank J Gonzalez; Harry V Gelboin; Kenneth R Korzekwa
Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.
Biochemistry 1994;33(21):6450-5.
1994: Ying-Hue Lee; J A Alberta; Frank J Gonzalez; D J Waxman
Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression.
The Journal of biological chemistry 1994;269(20):14681-9.
1994: M Czerwinski; T L McLemore; Harry V Gelboin; Frank J Gonzalez
Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors.
Cancer research 1994;54(4):1085-91.
1994: Ying-Hue Lee; M Yano; S Y Liu; E Matsunaga; Peter F Johnson; Frank J Gonzalez
A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor.
Molecular and cellular biology 1994;14(2):1383-94.
1994: P J Wedlund; Shioko Kimura; Frank J Gonzalez; Daniel W Nebert
1462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of east Mediterranean descent.
Pharmacogenetics 1994;4(1):21-6.
1993: S Imaoka; H Ogawa; S Kimura; Frank J Gonzalez
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney.
DNA and cell biology 1993;12(10):893-9.
1993: Deanna L Kroetz; O W McBride; Frank J Gonzalez
Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms.
Biochemistry 1993;32(43):11606-17.
1993: S Imaoka; P J Wedlund; H Ogawa; S Kimura; Frank J Gonzalez; H Y Kim
Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase.
The Journal of pharmacology and experimental therapeutics 1993;267(2):1012-6.
1993: Frank J Gonzalez
Molecular biology of human xenobiotic-metabolizing cytochromes P450: role of vaccinia virus cDNA expression in evaluating catalytic function.
Toxicology 1993;82(1-3):77-88.
1993: H Yokota; S Tamura; H Furuya; Shioko Kimura; M Watanabe; I Kanazawa; I Kondo; Frank J Gonzalez
Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.
Pharmacogenetics 1993;3(5):256-63.
1993: T Sher; H F Yi; O W McBride; Frank J Gonzalez
cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor.
Biochemistry 1993;32(21):5598-604.
1993: Frank J Gonzalez; S Y Liu; M Yano
Regulation of cytochrome P450 genes: molecular mechanisms.
Pharmacogenetics 1993;3(1):51-7.
1992: Frank J Gonzalez; C L Crespi; M Czerwinski; Harry V Gelboin
Analysis of human cytochrome P450 catalytic activities and expression.
The Tohoku journal of experimental medicine 1992;168(2):67-72.
1992: Frank J Gonzalez
Human cytochromes P450: problems and prospects.
Trends in pharmacological sciences 1992;13(9):346-52.
1992: S J Smith; Kenneth R Korzekwa; T Aoyama; Frank J Gonzalez; J F Darbyshire; K Sugiyama; J R Gillette
12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(4):566-71.
1992: M Yano; E Falvey; Frank J Gonzalez
Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene.
Molecular and cellular biology 1992;12(6):2847-54.
1992: S S Park; W Walker; T Aoyama; D P Lapenson; D J Waxman; Frank J Gonzalez; Harry V Gelboin
Monoclonal antibodies to rat liver microsomal cytochrome b5.
Biochemical pharmacology 1992;43(10):2201-8.
1992: N Hanioka; Frank J Gonzalez; N A Lindberg; G Liu; Harry V Gelboin; Kenneth R Korzekwa
Site-directed mutagenesis of cytochrome P450s CYP2A1 and CYP2A2: influence of the distal helix on the kinetics of testosterone hydroxylation.
Biochemistry 1992;31(13):3364-70.
1992: S Tamura; Kenneth R Korzekwa; S Kimura; Harry V Gelboin; Frank J Gonzalez
Baculovirus-mediated expression and functional characterization of human NADPH-P450 oxidoreductase.
Archives of biochemistry and biophysics 1992;293(2):219-23.
1991: Murali K Cherukuri; William DeGraff; S Tamura; Frank J Gonzalez; Amram Samuni; Angelo Russo; James B Mitchell
Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.
Cancer research 1991;51(24):6622-8.
1991: K Mizuno; Frank J Gonzalez; S Kimura
Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1.
Molecular and cellular biology 1991;11(10):4927-33.
1991: D J Waxman; D P Lapenson; T Aoyama; Harry V Gelboin; Frank J Gonzalez; Kenneth R Korzekwa
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
Archives of biochemistry and biophysics 1991;290(1):160-6.
1991: H Furuya; Urs A Meyer; Harry V Gelboin; Frank J Gonzalez
Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.
Molecular pharmacology 1991;40(3):375-82.
1991: Frank J Gonzalez; Urs A Meyer
Molecular genetics of the debrisoquin-sparteine polymorphism.
Clinical pharmacology and therapeutics 1991;50(3):233-8.
1991: M Czerwinski; T L McLemore; R M Philpot; P T Nhamburo; Kenneth R Korzekwa; Harry V Gelboin; Frank J Gonzalez
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism.
Cancer research 1991;51(17):4636-8.
1991: Allen E Bale; A L Mitchell; Frank J Gonzalez; O W McBride
Localization of CYP2F1 by multipoint linkage analysis and pulsed-field gel electrophoresis.
Genomics 1991;10(1):284-6.
1991: Frank J Gonzalez; Harry V Gelboin
Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression.
Progress in clinical and biological research 1991;372():11-20.
1991: Frank J Gonzalez; T Ueno; M Umeno; B J Song; R L Veech; Harry V Gelboin
Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1991;1():97-101.
1990: Frank J Gonzalez; S Y Liu; C A Kozak; Daniel W Nebert
Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7.
DNA and cell biology 1990;9(10):771-6.
1990: F Kikkawa; Frank J Gonzalez; S Kimura
Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs upstream of the human thyroid peroxidase gene.
Molecular and cellular biology 1990;10(12):6216-24.
1990: N Hanioka; Shioko Kimura; Urs A Meyer; Frank J Gonzalez
The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site.
American journal of human genetics 1990;47(6):994-1001.
1990: E Matsunaga; T Zeugin; Uli Zanger; T Aoyama; Urs A Meyer; Frank J Gonzalez
Sequence requirements for cytochrome P-450IID1 catalytic activity. A single amino acid change (Ile380 Phe) specifically decreases Vmax of the enzyme for bufuralol but not debrisoquine hydroxylation.
The Journal of biological chemistry 1990;265(28):17197-201.
1990: T Ueno; Frank J Gonzalez
Transcriptional control of the rat hepatic CYP2E1 gene.
Molecular and cellular biology 1990;10(9):4495-505.
1990: H Sugimura; Neil E Caporaso; G L Shaw; rama modali; Frank J Gonzalez; Robert N Hoover; James Resau; BF Trump; Ainsley Weston; Curtis C Harris
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
Carcinogenesis 1990;11(9):1527-30.
1990: T Ueno; Frank J Gonzalez
Complete sequence of the rat CYP2A3 gene specifically transcribed in lung.
Nucleic acids research 1990;18(15):4623-4.
1990: T Aoyama; James P Hardwick; S Imaoka; Y Funae; Harry V Gelboin; Frank J Gonzalez
Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha.
Journal of lipid research 1990;31(8):1477-82.
1990: N Hanioka; Kenneth R Korzekwa; Frank J Gonzalez
Sequence requirements for cytochromes P450IIA1 and P450IIA2 catalytic activity: evidence for both specific and non-specific substrate binding interactions through use of chimeric cDNAs and cDNA expression.
Protein engineering 1990;3(7):571-5.
1990: E Matsunaga; Frank J Gonzalez
Specific cytosine demethylations within the first exons of the rat CYP2D3 and CYP2D5 genes are associated with activation of hepatic gene expression during development.
DNA and cell biology 1990;9(6):443-52.
1990: T Aoyama; K Nagata; Y Yamazoe; R Kato; E Matsunaga; Harry V Gelboin; Frank J Gonzalez
Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5425-9.
1990: P T Nhamburo; S Kimura; O W McBride; C A Kozak; Harry V Gelboin; Frank J Gonzalez
The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping.
Biochemistry 1990;29(23):5491-9.
1990: Frank J Gonzalez; Daniel W Nebert
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.
Trends in genetics : TIG 1990;6(6):182-6.
1990: T Aoyama; S Yamano; P S Guzelian; Harry V Gelboin; Frank J Gonzalez
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4790-3.
1990: T Aoyama; Kenneth R Korzekwa; K Nagata; J Gillette; Harry V Gelboin; Frank J Gonzalez
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s.
Endocrinology 1990;126(6):3101-6.
1990: T Aoyama; Kenneth R Korzekwa; T Matsunaga; K Nagata; J Gillette; Harry V Gelboin; Frank J Gonzalez
cDNA-directed expression of rat P450s IIA1 and IIA2. Catalytic activities toward steroids and xenobiotics and comparison with the enzymes purified from liver.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(3):378-82.
1990: T Aoyama; Harry V Gelboin; Frank J Gonzalez
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450.
Cancer research 1990;50(7):2060-3.
1990: Richard C Robinson; K Nagata; Harry V Gelboin; J Rifkind; Frank J Gonzalez; Fred Friedman
Developmental regulation of hepatic testosterone hydroxylases: simultaneous activation and repression of constitutively expressed cytochromes P450 in senescent rats.
Archives of biochemistry and biophysics 1990;277(1):42-6.
1990: T Matsunaga; M Nomoto; C A Kozak; Frank J Gonzalez
Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7.
Biochemistry 1990;29(5):1329-41.
1990: S Yamano; J Tatsuno; Frank J Gonzalez
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.
Biochemistry 1990;29(5):1322-9.
1990: E Matsunaga; M Umeno; Frank J Gonzalez
The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site.
Journal of molecular evolution 1990;30(2):155-69.
1990: Frank J Gonzalez; T Aoyama; Harry V Gelboin
Activation of promutagens by human cDNA-expressed cytochrome P450s.
Progress in clinical and biological research 1990;340B():77-86.
1990: Frank J Gonzalez
Hereditary polymorphisms of human drug metabolizing enzymes and cancer susceptibility.
Birth defects original article series 1990;26(1):17-42.
1990: Harry V Gelboin; S S Park; T Aoyama; T Fujino; C L Crespi; Frank J Gonzalez
Mapping of cytochrome P-450 distribution and function with monoclonal antibodies and cDNA expression.
Princess Takamatsu symposia 1990;21():3-16.
1990: Frank J Gonzalez; Harry V Gelboin
Transcriptional and posttranscriptional regulation of CYP2E1, an N-nitrosodimethylamine demethylase.
Princess Takamatsu symposia 1990;21():157-64.
1989: T Aoyama; Kenneth R Korzekwa; K Nagata; Milton Adesnik; A Reiss; D P Lapenson; J Gillette; Harry V Gelboin; D J Waxman; Frank J Gonzalez
Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine.
The Journal of biological chemistry 1989;264(35):21327-33.
1989: Shioko Kimura; M Umeno; Radek C Skoda; Urs A Meyer; Frank J Gonzalez
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.
American journal of human genetics 1989;45(6):889-904.
1989: A Asseffa; S J Smith; K Nagata; J Gillette; Harry V Gelboin; Frank J Gonzalez
Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus.
Archives of biochemistry and biophysics 1989;274(2):481-90.
1989: P T Nhamburo; Frank J Gonzalez; O W McBride; Harry V Gelboin; S Kimura
Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping.
Biochemistry 1989;28(20):8060-6.
1989: E Matsunaga; Uli Zanger; James P Hardwick; Harry V Gelboin; Urs A Meyer; Frank J Gonzalez
The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.
Biochemistry 1989;28(18):7349-55.
1989: S Yamano; P T Nhamburo; T Aoyama; Urs A Meyer; T Inaba; W Kalow; Harry V Gelboin; O W McBride; Frank J Gonzalez
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.
Biochemistry 1989;28(18):7340-8.
1989: Shioko Kimura; James P Hardwick; C A Kozak; Frank J Gonzalez
The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.
DNA (Mary Ann Liebert, Inc.) 1989;8(7):517-25.
1989: Shioko Kimura; N Hanioka; E Matsunaga; Frank J Gonzalez
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
DNA (Mary Ann Liebert, Inc.) 1989;8(7):503-16.
1989: S Yamano; T Aoyama; O W McBride; James P Hardwick; Harry V Gelboin; Frank J Gonzalez
Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7.
Molecular pharmacology 1989;36(1):83-8.
1989: S Yamano; K Nagata; Y Yamazoe; R Kato; Harry V Gelboin; Frank J Gonzalez
cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3).
Nucleic acids research 1989;17(12):4888.
1989: S Kimura; C A Kozak; Frank J Gonzalez
Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene.
Biochemistry 1989;28(9):3798-803.
1989: T Aoyama; Frank J Gonzalez; Harry V Gelboin
Human cDNA-expressed cytochrome P450 IA2: mutagen activation and substrate specificity.
Molecular carcinogenesis 1989;2(4):192-8.
1989: T Aoyama; Frank J Gonzalez; Harry V Gelboin
Mutagen activation by cDNA-expressed P(1)450, P(3)450, and P450a.
Molecular carcinogenesis 1989;1(4):253-9.
1988: M Umeno; O W McBride; C S Yang; Harry V Gelboin; Frank J Gonzalez
Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression.
Biochemistry 1988;27(25):9006-13.
1988: T Matsunaga; K Nagata; Elzbieta Holsztynska; D P Lapenson; A Smith; R Kato; Harry V Gelboin; D J Waxman; Frank J Gonzalez
Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase.
The Journal of biological chemistry 1988;263(34):17995-8002.
1988: R M Long; H Satoh; Brian M Martin; S Kimura; Frank J Gonzalez; Lance R Pohl
Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence for a multigene family.
Biochemical and biophysical research communications 1988;156(2):866-73.
1988: M Umeno; S Morris; E Matsunaga; Harry V Gelboin; Frank J Gonzalez
Sequence of the 5' end of the developmentally regulated rat P450 PB1 (P450IIC6) gene.
Nucleic acids research 1988;16(13):6249.
1988: M Umeno; B J Song; Christine A Kozak; Harry V Gelboin; Frank J Gonzalez
The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation.
The Journal of biological chemistry 1988;263(10):4956-62.
1988: Frank J Gonzalez; B J Schmid; M Umeno; O W Mcbride; James P Hardwick; Urs A Meyer; Harry V Gelboin; Jeffrey Idle
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
DNA (Mary Ann Liebert, Inc.) 1988;7(2):79-86.
1988: Frank J Gonzalez; Radek C Skoda; Shioko Kimura; M Umeno; Uli Zanger; Daniel W Nebert; Harry V Gelboin; James P Hardwick; Urs A Meyer
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.
Nature 1988;331(6155):442-6.
1988: Frank J Gonzalez; FRancis VILBOIS; James P Hardwick; O W McBride; Daniel W Nebert; Harry V Gelboin; Urs A Meyer
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
Genomics 1988;2(2):174-9.
1987: S Kimura; J Pastewka; Harry V Gelboin; Frank J Gonzalez
cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.
Nucleic acids research 1987;15(23):10053-4.
1987: O W McBride; M Umeno; Harry V Gelboin; Frank J Gonzalez
A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E).
Nucleic acids research 1987;15(23):10071.