FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Christopher Goodnow

Research Profile

Living Beings

Anatomy

Physiology

Chemicals & Drugs

Disorders

Autoimmunity

Co-author Network

Publications

TOP 3
Alvin Pratama; Roybel R Ramiscal; Diego G Silva; Di Yu; Vicki Athanasopoulos; David Bernal; Natalia K Botelho; Pheh-Ping Chang; Matthew C Cook; Souvik K Das; Jessica Fitch; Christopher C Goodnow; Jennifer J Hogan; Xin Hu; Heinrich Korner; Paula Maña; Carola G Vinuesa
Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation.
T D Andrews; G Sjollema; Christopher C Goodnow
Understanding the immunological impact of the human mutation explosion.
Stephen R Daley; Daniel Y Hu; Christopher C Goodnow
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Christopher Goodnow (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Alvin Pratama; Roybel R Ramiscal; Diego G Silva; Di Yu; Vicki Athanasopoulos; David Bernal; Natalia K Botelho; Pheh-Ping Chang; Matthew C Cook; Souvik K Das; Jessica Fitch; Christopher C Goodnow; Jennifer J Hogan; Xin Hu; Heinrich Korner; Paula Maña; Carola G Vinuesa
Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation.
Immunity 2013;38(4):669-80.
2013: T D Andrews; G Sjollema; Christopher C Goodnow
Understanding the immunological impact of the human mutation explosion.
Trends in immunology 2013;34(3):99-106.
2013: Stephen R Daley; Daniel Y Hu; Christopher C Goodnow
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.
The Journal of experimental medicine 2013;210(2):269-85.
2013: Hannes Bergmann; Edward M Bertram; Katherine R Bull; Richard J Cornall; T Daniel Andrews; Bhavani Balakishnan; Nadine Barthel; Matthew A Field; Christopher C Goodnow; Keisuke Horikawa; Yogesh Jeelall; Fabienne Mackay; Lisa Miosge; Andrew J Rimmer; Carla M Roots; Alanna Short; Geoff Sjollema; Charis E Teh; Belinda Whittle; Mehmet Yabas; Anselm Enders
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.
The Journal of experimental medicine 2013;210(1):31-40.
2013: Katherine R Bull; Edward M Bertram; Bruce Beutler; Steve D M Brown; Tanya L Crockford; Anselm Enders; Christopher C Goodnow; Gerton Lunter; Ann-Marie Mallon; Lisa A Miosge; Paul Potter; Andrew J Rimmer; Carla M Roots; Owen M Siggs; Michelle M Simon; Belinda Whittle; Richard J Cornall
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.
PLoS genetics 2013;9(1):e1003219.
2012: Yogesh S Jeelall; Axel Kallies; Hsei-Di Law; Stephen L Nutt; James Q Wang; Heather Domaschenz; Herman K H Fung; Christopher C Goodnow; Keisuke Horikawa
Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.
The Journal of experimental medicine 2012;209(11):1907-17.
2012: John A Altin; Christopher C Goodnow; Matthew C Cook
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5478-88.
2012: T D Andrews; B Balakishnan; B Beutler; V Cho; A Enders; M A Field; J Hager; M Kirk; Y Shao; M Singh; G Sjollema; B Whittle; S Winslade; Y Xia; Y Zhang; Christopher C Goodnow
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
Open biology 2012;2(5):120061.
2012: Jennifer C Y Lo; Anne E O'Connor; Christopher J Ormandy; James C Whisstock; Belinda Whittle; Vicki Adams; R John Aitken; Claire Borg; Brett J Clark; Mark C Field; Christopher C Goodnow; Tomomoto Ishikawa; Duangporn Jamsai; Moira K O'Bryan
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.
PLoS genetics 2012;8(10):e1002969.
2011: Yovina Sontani; Peter Papathanasiou; Gavin Chapman; Sally Dunwoodie; Christopher C Goodnow; Gerard F Hoyne
Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL.
Leukemia research 2011;35(11):1512-9.
2011: Katrina L Randall; Sarah Russell; Joanne M Smart; Andy Tan; Stuart G Tangye; Mehmet Yabas; Marco A Yamazaki-Nakashimada; Maria de la Luz Garcia-Cruz; Wafaa Al Suwairi; Peter D Arkwright; Edward M Bertram; Jean-Laurent Casanova; Stephanie S-Y Chan; Richard J Cornall; Ivan Fung; Emmanuelle Jouanguy; Teresa Lambe; Saul Oswaldo Lugo Reyes; Cindy S Ma; Yan Mei; Satoshi Okada; Jane Oliaro; Capucine Picard; Christopher C Goodnow
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
The Journal of experimental medicine 2011;208(11):2305-20.
2011: Lei Tian; Lydia E Makaroff; John A Altin; Matthew C Cook; James Dooley; Dean Franckaert; Christopher C Goodnow; Adrian Liston
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.
Blood 2011;118(7):1845-53.
2011: Diego G Silva; Charis E Teh; Stephen R Daley; Christopher C Goodnow; Jennifer Hogan; Daniel Y Hu; Kong-Peng Lam; Sau K Lee; Carola G Vinuesa
Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells.
Diabetes 2011;60(8):2102-11.
2011: Mehmet Yabas; Charis E Teh; Sandra Frankenreiter; Dennis Lal; Carla M Roots; Belinda Whittle; Daniel T Andrews; Yafei Zhang; Narci C Teoh; Jonathan Sprent; Lina E Tze; Edyta M Kucharska; Jennifer Kofler; Geoffrey C Farell; Stefan Broer; Christopher C Goodnow; Anselm Enders
ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes.
Nature immunology 2011;12(5):441-9.
2011: John A Altin; Lei Tian; Adrian Liston; Edward M Bertram; Christopher C Goodnow; Matthew C Cook
Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy.
The Journal of allergy and clinical immunology 2011;127(5):1277-85.e5.
2011: Gerard F Hoyne; Eleanor Flening; Mehmet Yabas; Charis Teh; John A Altin; Katrina Randall; Christine B F Thien; Wallace Y Langdon; Christopher C Goodnow
Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2024-32.
2011: Lina E Tze; Keisuke Horikawa; Heather Domaschenz; Debbie R Howard; Carla M Roots; Robert J Rigby; David A Way; Mari Ohmura-Hoshino; Satoshi Ishido; Christopher E Andoniou; Mariapia A Degli-Esposti; Christopher C Goodnow
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation.
The Journal of experimental medicine 2011;208(1):149-65.
2011: Mehmet Yabas; Dale I Godfrey; Christopher C Goodnow; Gerard F Hoyne
Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells.
PloS one 2011;6(11):e26440.
2010: Carola G Vinuesa; Michelle A Linterman; Christopher C Goodnow; Katrina L Randall
T cells and follicular dendritic cells in germinal center B-cell formation and selection.
Immunological reviews 2010;237(1):72-89.
2010: Charis E Teh; Stephen R Daley; Anselm Enders; Christopher C Goodnow
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(33):14709-14.
2010: Christopher C Goodnow; Carola G Vinuesa; Katrina L Randall; Fabienne Mackay; Robert Brink
Control systems and decision making for antibody production.
Nature immunology 2010;11(8):681-8.
2010: Zuopeng Wu; Adele L Yates; Gerard F Hoyne; Christopher C Goodnow
Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):231-8.
2010: Julie Zikherman; Craig Jenne; Susan Watson; Kristin Doan; William Raschke; Christopher C Goodnow; Arthur Weiss
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
Immunity 2010;32(3):342-54.
2010: Nicholas Simpson; Paul A Gatenby; Anastasia Wilson; Shreya Malik; David A Fulcher; Stuart G Tangye; Harinder Manku; Timothy J Vyse; Giovanna Roncador; Gavin A Huttley; Christopher C Goodnow; Carola G Vinuesa; Matthew C Cook
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.
Arthritis and rheumatism 2010;62(1):234-44.
2010: Angelo Theodoratos; BL Whittle; Anselm Enders; David C Tscharke; Carla M Roots; Christopher C Goodnow; Aude M Fahrer
Mouse strains with point mutations in TAP1 and TAP2.
Immunology and cell biology 2010;88(1):72-8.
2009: Katrina L Randall; Teresa Lambe; Andy L Johnson; Andy Johnson; Bebhinn Treanor; Edyta Kucharska; Heather Domaschenz; Belinda Whittle; Lina E Tze; Anselm Enders; Tanya L Crockford; Tiphaine Bouriez-Jones; Duncan Alston; Jason G Cyster; Michael J Lenardo; Fabienne Mackay; Elissa K Deenick; Stuart G Tangye; Tyani D Chan; Tahra Camidge; Robert Brink; Carola G Vinuesa; Facundo D Batista; Richard J Cornall; Christopher C Goodnow
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Nature immunology 2009;10(12):1283-91.
2009: Craig N Jenne; Anselm Enders; Richard Rivera; Susan R Watson; Alexander J Bankovich; Joao P Pereira; Ying Xu; Carla M Roots; Joshua Beilke; Arnob Banerjee; Steven L Reiner; Sara A Miller; Amy S Weinmann; Christopher C Goodnow; Lewis L Lanier; Jason G Cyster; Jerold Chun
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
The Journal of experimental medicine 2009;206(11):2469-81.
2009: Andy L Johnson; L Aravind; Natalia Shulzhenko; Andrey Morgun; See-Young Choi; Tanya L Crockford; Teresa Lambe; Heather Domaschenz; Edyta M Kucharska; Lixin Zheng; Carola G Vinuesa; Michael J Lenardo; Christopher C Goodnow; Richard J Cornall; Ronald H Schwartz
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Nature immunology 2009;10(8):831-9.
2009: Anastasia Nijnik; Sara Dawson; Tanya L Crockford; Lisa Woodbine; Supawan Visetnoi; Sophia Bennett; Margaret Jones; Gareth D H Turner; Penny A Jeggo; Christopher C Goodnow; Richard J Cornall
Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.
The Journal of clinical investigation 2009;119(6):1696-705.
2009: Michelle A Linterman; Robert J Rigby; Raphael Wong; Diego Silva; David Withers; Graham Anderson; Naresh K Verma; Robert Brink; Andreas Hutloff; Christopher C Goodnow; Carola G Vinuesa
Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
Immunity 2009;30(2):228-41.
2009: Teresa Lambe; Robert J Simpson; Sara Dawson; Tiphaine Bouriez-Jones; Tanya L Crockford; Michelle Lepherd; Gladys O Latunde-Dada; Hannah Robinson; Kishor B Raja; Dean R Campagna; Guadalupe Villarreal; J Clive Ellory; Christopher C Goodnow; Mark D Fleming; Andrew T McKie; Richard J Cornall
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
Blood 2009;113(8):1805-8.
2008: Lawrence R Shiow; David W Roadcap; Kenneth Paris; Susan R Watson; Irina L Grigorova; Tonya Lebet; Jinping An; Ying Xu; Craig N Jenne; Niko Föger; Ricardo U Sorensen; Christopher C Goodnow; James E Bear; Jennifer M Puck; Jason G Cyster
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Nature immunology 2008;9(11):1307-15.
2008: Katharine M Gosling; Christopher C Goodnow; Naresh K Verma; Aude M Fahrer
Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse.
Immunology 2008;125(2):208-17.
2008: Janelle R Keys; Michael R Tallack; Ye Zhan; Peter Papathanasiou; Christopher C Goodnow; Karin M Gaensler; Merlin Crossley; Job Dekker; Andrew C Perkins
A mechanism for Ikaros regulation of human globin gene switching.
British journal of haematology 2008;141(3):398-406.
2008: Chad K Heazlewood; Matthew C Cook; Rajaraman Eri; Gareth R Price; Sharyn B Tauro; Douglas Taupin; David J Thornton; Chin Wen Png; Tanya L Crockford; Richard J Cornall; Rachel Adams; Masato Kato; Keats Nelms; Nancy A Hong; Timothy H J Florin; Christopher C Goodnow; Michael A McGuckin
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.
PLoS medicine 2008;5(3):e54.
2008: Man Liu; Jamie L Duke; Daniel J Richter; Carola G Vinuesa; Christopher C Goodnow; Steven H Kleinstein; David G Schatz
Two levels of protection for the B cell genome during somatic hypermutation.
Nature 2008;451(7180):841-5.
2008: Di Yu; Matthew C Cook; Dong-Mi Shin; Diego G Silva; Jennifer Marshall; Kai-Michael Toellner; Wendy L Havran; Pico Caroni; Michael P Cooke; Herbert C Morse; Ian C M MacLennan; Christopher C Goodnow; Carola G Vinuesa
Axon growth and guidance genes identify T-dependent germinal centre B cells.
Immunology and cell biology 2008;86(1):3-14.
2007: Owen M Siggs; Lisa A Miosge; Adèle L Yates; Edyta M Kucharska; Daniel Sheahan; Tomas Brdicka; Arthur Weiss; Adrian Liston; Christopher C Goodnow
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
Immunity 2007;27(6):912-26.
2007: Di Yu; Andy Hee-Meng Tan; Xin Hu; Vicki Athanasopoulos; Nicholas Simpson; Diego G Silva; Andreas Hutloff; Keith Giles; Peter J Leedman; Kong-Peng Lam; Christopher C Goodnow; Carola G Vinuesa
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.
Nature 2007;450(7167):299-303.
2007: Christopher C Goodnow
Nossal and Pike 1975: a turning point in the effort to define self-tolerance mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5617-8.
2007: Katharine M Gosling; Lydia E Makaroff; Angelo Theodoratos; Yong-Hee Kim; Belinda Whittle; Lixin Rui; Hua Wu; Nancy A Hong; Gavin C Kennedy; Julie-Anne Fritz; Adele L Yates; Christopher C Goodnow; Aude M Fahrer
A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12445-50.
2007: Christopher C Goodnow
Multistep pathogenesis of autoimmune disease.
Cell 2007;130(1):25-35.
2007: Anastasia Nijnik; Lisa Woodbine; Caterina Marchetti; Sara Dawson; Teresa Lambe; Cong Liu; Neil P Rodrigues; Tanya L Crockford; Erik Cabuy; Alessandro Vindigni; Tariq Enver; John I Bell; Predrag Slijepcevic; Christopher C Goodnow; Penny A Jeggo; Richard J Cornall
DNA repair is limiting for haematopoietic stem cells during ageing.
Nature 2007;447(7145):686-90.
2007: Adrian Liston; Owen M Siggs; Christopher C Goodnow
Tracing the action of IL-2 in tolerance to islet-specific antigen.
Immunology and cell biology 2007;85(4):338-42.
2007: Keisuke Horikawa; Stephen W Martin; Sarah L Pogue; Karlee Silver; Kaiman Peng; Kiyoshi Takatsu; Christopher C Goodnow
Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors.
The Journal of experimental medicine 2007;204(4):759-69.
2007: Christopher C Goodnow; James A Campbell; Lixin Rui; Carola G Vinuesa
Tolerance mechanisms in the late phase of the antibody response.
Advances in experimental medicine and biology 2007;596():163-8.
2007: Adrian Liston; Kristine Hardy; Yvonne Pittelkow; Susan R Wilson; Lydia E Makaroff; Aude M Fahrer; Christopher C Goodnow
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling.
Genome biology 2007;8(1):R12.
2006: Daniel H D Gray; Natalie Seach; Tomoo Ueno; Morag K Milton; Adrian Liston; Andrew M Lew; Christopher C Goodnow; Richard L Boyd
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.
Blood 2006;108(12):3777-85.
2006: Warren S Alexander; Elizabeth M Viney; Jian-Guo Zhang; Donald Metcalf; Maria Kauppi; Craig D Hyland; Marina R Carpinelli; William Stevenson; Ben A Croker; Adrienne A Hilton; Sarah Ellis; Carly Selan; Harshal H Nandurkar; Christopher C Goodnow; Benjamin T Kile; Nicos A Nicola; Andrew W Roberts; Douglas J Hilton
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16442-7.
2006: Lixin Rui; James I Healy; Julie Blasioli; Christopher C Goodnow
ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5337-46.
2006: Anthony P Manderson; Ben J C Quah; Marina Botto; Christopher C Goodnow; Mark J Walport; Christopher R Parish
A novel mechanism for complement activation at the surface of B cells following antigen binding.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5155-62.
2006: Matthew C Cook; Carola G Vinuesa; Christopher C Goodnow
ENU-mutagenesis: insight into immune function and pathology.
Current opinion in immunology 2006;18(5):627-33.
2006: Mathieu Bléry; Lina Tze; Lisa A Miosge; Jesse E Jun; Christopher C Goodnow
Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy.
The Journal of experimental medicine 2006;203(7):1773-83.
2006: Anastasia Nijnik; Helen Ferry; Graham Lewis; Eleni Rapsomaniki; Janson C H Leung; Angelika Daser; Teresa Lambe; Christopher C Goodnow; Richard J Cornall
Spontaneous B cell hyperactivity in autoimmune-prone MRL mice.
International immunology 2006;18(7):1127-37.
2006: Todor Arsov; Diego G Silva; Moira K O'Bryan; Amanda Sainsbury; Nicola J Lee; Claire Kennedy; Shehnaaz S M Manji; Keats Nelms; Conan Liu; Carola G Vinuesa; David M de Kretser; Christopher C Goodnow; Nikolai Petrovsky
Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis.
Molecular endocrinology (Baltimore, Md.) 2006;20(7):1610-22.
2006: Christopher C Goodnow
Immunology. Discriminating microbe from self suffers a double toll.
Science (New York, N.Y.) 2006;312(5780):1606-8.
2006: Lixin Rui; Christopher C Goodnow
Lymphoma and the control of B cell growth and differentiation.
Current molecular medicine 2006;6(3):291-308.
2006: Todor Arsov; Claire Z Larter; Christopher J Nolan; Nikolai Petrovsky; Christopher C Goodnow; Narcissus C Teoh; Matthew M Yeh; Geoffrey C Farrell
Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice.
Biochemical and biophysical research communications 2006;342(4):1152-9.
2006: Gerard F Hoyne; Christopher C Goodnow
The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity.
Immunological reviews 2006;210():27-39.
2005: Helen Ferry; Tanya L Crockford; Tanya L Cockford; Karlee Silver; Nigel Rust; Christopher C Goodnow; Richard J Cornall
Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival.
European journal of immunology 2005;35(12):3655-63.
2005: Lisa A Miosge; Christopher C Goodnow
Genes, pathways and checkpoints in lymphocyte development and homeostasis.
Immunology and cell biology 2005;83(4):318-35.
2005: Christopher C Goodnow; Jonathon Sprent; Barbara Fazekas De St Groth; Carola G Vinuesa
Cellular and genetic mechanisms of self tolerance and autoimmunity.
Nature 2005;435(7042):590-7.
2005: Carola G Vinuesa; Matthew C Cook; Constanza Angelucci; Vicki Athanasopoulos; Lixin Rui; Kim M Hill; Di Yu; Heather Domaschenz; Belinda Whittle; Teresa Lambe; Ian S D Roberts; Richard R Copley; John I Bell; Richard J Cornall; Christopher C Goodnow
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.
Nature 2005;435(7041):452-8.
2005: Adrian Liston; Sylvie Lesage; Daniel H D Gray; Richard L Boyd; Christopher C Goodnow
Genetic lesions in T-cell tolerance and thresholds for autoimmunity.
Immunological reviews 2005;204():87-101.
2005: Peter Papathanasiou; Christopher C Goodnow
Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system.
Annual review of genetics 2005;39():241-62.
2005: Adrian Liston; Christopher C Goodnow
Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity.
Novartis Foundation symposium 2005;267():180-92; discussion 192-9.
2004: Adrian Liston; Sylvie Lesage; Daniel H D Gray; Lorraine A O'Reilly; Andreas Strasser; Aude M Fahrer; Richard L Boyd; Judith Wilson; Alan G Baxter; Elena M Gallo; Gerald R Crabtree; Kaiman Peng; Susan R Wilson; Christopher C Goodnow
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.
Immunity 2004;21(6):817-30.
2004: Adrian Liston; Daniel H D Gray; Sylvie Lesage; Anne L Fletcher; Judith Wilson; Kylie E Webster; Hamish Scott; Richard L Boyd; Leena Peltonen; Christopher C Goodnow
Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.
The Journal of experimental medicine 2004;200(8):1015-26.
2004: Carola G Vinuesa; Christopher C Goodnow
Illuminating autoimmune regulators through controlled variation of the mouse genome sequence.
Immunity 2004;20(6):669-79.
2003: Jesse E Jun; Christopher C Goodnow
Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.
Nature immunology 2003;4(11):1057-64.
2003: Peter Papathanasiou; Andrew C Perkins; Bradley S Cobb; Roger Ferrini; Rupa Sridharan; Gerard F Hoyne; Keats Nelms; Stephen T Smale; Christopher C Goodnow
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.
Immunity 2003;19(1):131-44.
2003: Jesse E Jun; Lauren E Wilson; Carola G Vinuesa; Sylvie Lesage; Mathieu Blery; Lisa A Miosge; Matthew C Cook; Edyta M Kucharska; Hiromitsu Hara; Josef M Penninger; Heather Domashenz; Nancy A Hong; Richard J Glynne; Keats Nelms; Christopher C Goodnow
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.
Immunity 2003;18(6):751-62.
2003: Lixin Rui; Carola G Vinuesa; Julie Blasioli; Christopher C Goodnow
Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling.
Nature immunology 2003;4(6):594-600.
2003: Adrian Liston; Sylvie Lesage; Judith Wilson; Leena Peltonen; Christopher C Goodnow
Aire regulates negative selection of organ-specific T cells.
Nature immunology 2003;4(4):350-4.
2002: Carola G Vinuesa; Matthew C Cook; Michael P Cooke; Ian C M MacLennan; Christopher C Goodnow
Analysis of B cell memory formation using DNA microarrays.
Annals of the New York Academy of Sciences 2002;975():33-45.
2002: Sylvie Lesage; Suzanne B Hartley; Srinivas Akkaraju; Judith Wilson; Michelle Townsend; Christopher C Goodnow
Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.
The Journal of experimental medicine 2002;196(9):1175-88.
2002: Lisa A Miosge; Julie Blasioli; Mathieu Blery; Christopher C Goodnow
Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kappaB2 in regulating circulating B cell numbers.
The Journal of experimental medicine 2002;196(8):1113-9.
2002: Simon J Prasad; Christopher C Goodnow
Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo.
International immunology 2002;14(6):677-84.
2002: Carola G Vinuesa; Christopher C Goodnow
Immunology: DNA drives autoimmunity.
Nature 2002;416(6881):595-8.
2002: Simon J Prasad; Christopher C Goodnow
Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes.
Immunology and cell biology 2002;80(2):198-206.
2002: Adèle L Loy; Christopher C Goodnow
Novel approaches for identifying genes regulating lymphocyte development and function.
Current opinion in immunology 2002;14(2):260-5.
2002: Stephen W Martin; Christopher C Goodnow
Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory.
Nature immunology 2002;3(2):182-8.
2002: Julie Blasioli; Christopher C Goodnow
Lyn/CD22/SHP-1 and their importance in autoimmunity.
Current directions in autoimmunity 2002;5():151-60.
2001: Sylvie Lesage; Christopher C Goodnow
Organ-specific autoimmune disease: a deficiency of tolerogenic stimulation.
The Journal of experimental medicine 2001;194(5):F31-6.
2001: Keats Nelms; Christopher C Goodnow
Genome-wide ENU mutagenesis to reveal immune regulators.
Immunity 2001;15(3):409-18.
2001: Christopher C Goodnow
Pathways for self-tolerance and the treatment of autoimmune diseases.
Lancet 2001;357(9274):2115-21.
2001: Aude M Fahrer; J. Fernando Bazan; Peter Papathanasiou; Keats Nelms; Christopher C Goodnow
A genomic view of immunology.
Nature 2001;409(6822):836-8.
2001: Christopher C Goodnow; Richard J Glynne; Srinivas Akkaraju; J Rayner; D Mack; James I Healy; S Chaudhry; Lisa A Miosge; L Wilson; Peter Papathanasiou; Adèle L Loy
Autoimmunity, self-tolerance and immune homeostasis: from whole animal phenotypes to molecular pathways.
Advances in experimental medicine and biology 2001;490():33-40.
2000: Richard J Glynne; Ghassan Ghandour; J Rayner; DH Mack; Christopher C Goodnow
B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays.
Immunological reviews 2000;176():216-46.
2000: BC Weintraub; Jesse E Jun; A C Bishop; Kevan M Shokat; M L Thomas; Christopher C Goodnow
Entry of B cell receptor into signaling domains is inhibited in tolerant B cells.
The Journal of experimental medicine 2000;191(8):1443-8.
2000: Richard J Glynne; Ghassan Ghandour; Christopher C Goodnow
Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy.
Current opinion in immunology 2000;12(2):210-4.
2000: Richard J Cornall; A M Cheng; T Pawson; Christopher C Goodnow
Role of Syk in B-cell development and antigen-receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1713-8.
2000: Richard J Glynne; Srinivas Akkaraju; James I Healy; J Rayner; Christopher C Goodnow; DH Mack
How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis.
Nature 2000;403(6770):672-6.
1999: S E Townsend; BC Weintraub; Christopher C Goodnow
Growing up on the streets: why B-cell development differs from T-cell development.
Immunology today 1999;20(5):217-20.
1999: Christopher C Goodnow; Richard J Glynne; D Mack; BC Weintraub; Jeffrey C Rathmell; James I Healy; S Chaudhry; Lisa A Miosge; Adèle L Loy; L Wilson
Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways.
Cold Spring Harbor symposia on quantitative biology 1999;64():313-22.
1999: Richard J Cornall; Christopher C Goodnow; Jason G Cyster
Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway.
Current topics in microbiology and immunology 1999;244():57-68.
1998: H Ying; James I Healy; Christopher C Goodnow; Jane R Parnes
Regulation of mouse CD72 gene expression during B lymphocyte development.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4760-7.
1998: Jeffrey C Rathmell; Christopher C Goodnow
The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro-environment.
Immunology and cell biology 1998;76(5):387-94.
1998: Jeffrey C Rathmell; S Fournier; B C Weintraub; James P Allison; Christopher C Goodnow
Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells.
The Journal of experimental medicine 1998;188(4):651-9.
1998: BC Weintraub; Christopher C Goodnow
Immune Responses: costimulatory receptors have their say.
Current biology : CB 1998;8(16):R575-7.
1998: S E Townsend; Christopher C Goodnow
Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo.
The Journal of experimental medicine 1998;187(10):1611-21.
1998: Richard J Cornall; Jason G Cyster; Margaret L Hibbs; Ashley R Dunn; KL Otipoby; Edward A Clark; Christopher C Goodnow
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.
Immunity 1998;8(4):497-508.
1998: James I Healy; Ricardo E Dolmetsch; Richard S Lewis; Christopher C Goodnow
Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes.
Novartis Foundation symposium 1998;215():137-44; discussion 144-5, 186-90.
1998: Richard J Cornall; Christopher C Goodnow
B cell antigen receptor signalling in the balance of tolerance and immunity.
Novartis Foundation symposium 1998;215():21-30; discussion 30-40.
1998: James I Healy; Christopher C Goodnow
Positive versus negative signaling by lymphocyte antigen receptors.
Annual review of immunology 1998;16():645-70.
1997: Srinivas Akkaraju; K Canaan; Christopher C Goodnow
Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells.
The Journal of experimental medicine 1997;186(12):2005-12.
1997: Luika Timmerman; James I Healy; SN Ho; Lei Chen; Christopher C Goodnow; Gerald R Crabtree
Redundant expression but selective utilization of nuclear factor of activated T cells family members.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2735-40.
1997: Srinivas Akkaraju; W Y Ho; D Leong; K Canaan; Mark M Davis; Christopher C Goodnow
A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.
Immunity 1997;7(2):255-71.
1997: A E Macaulay; Rosemarie H Dekruyff; Christopher C Goodnow; Dale T Umetsu
Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4171-9.
1997: Ricardo E Dolmetsch; Richard S Lewis; Christopher C Goodnow; James I Healy
Differential activation of transcription factors induced by Ca2+ response amplitude and duration.
Nature 1997;386(6627):855-8.
1997: Christopher C Goodnow
Balancing immunity, autoimmunity, and self-tolerance.
Annals of the New York Academy of Sciences 1997;815():55-66.
1997: Christopher C Goodnow
Chance encounters and organized rendezvous.
Immunological reviews 1997;156():5-10.
1997: Christopher C Goodnow; Jason G Cyster
Lymphocyte homing: the scent of a follicle.
Current biology : CB 1997;7(4):R219-22.
1997: James I Healy; Ricardo E Dolmetsch; Luika Timmerman; Jason G Cyster; M L Thomas; Gerald R Crabtree; Richard S Lewis; Christopher C Goodnow
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.
Immunity 1997;6(4):419-28.
1997: Christopher C Goodnow
Glimpses into the balance between immunity and self-tolerance.
Ciba Foundation symposium 1997;204():190-202; discussion 202-7.
1996: Jeffrey C Rathmell; S E Townsend; J C Xu; R A Flavell; Christopher C Goodnow
Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.
Cell 1996;87(2):319-29.
1996: Jason G Cyster; James I Healy; K Kishihara; T W Mak; M L Thomas; Christopher C Goodnow
Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45.
Nature 1996;381(6580):325-8.
1996: Roland S Liblau; Roland Tisch; Kevan M Shokat; X Yang; N Dumont; Christopher C Goodnow; Hugh McDevitt
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3031-6.
1996: Christopher C Goodnow
Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2264-71.
1996: P W Dempsey; M E Allison; Srinivas Akkaraju; Christopher C Goodnow; Douglas T Fearon
C3d of complement as a molecular adjuvant: bridging innate and acquired immunity.
Science (New York, N.Y.) 1996;271(5247):348-50.
1995: Jason G Cyster; Christopher C Goodnow
Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate.
Immunity 1995;3(6):691-701.
1995: Richard J Cornall; Christopher C Goodnow; Jason G Cyster
The regulation of self-reactive B cells.
Current opinion in immunology 1995;7(6):804-11.
1995: Jeffrey C Rathmell; Christopher C Goodnow
Autoimmunity. The Fas track.
Current biology : CB 1995;5(11):1218-21.
1995: Jason G Cyster; Christopher C Goodnow
Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords.
The Journal of experimental medicine 1995;182(2):581-6.
1995: Jeffrey C Rathmell; M P Cooke; W Y Ho; J Grein; S E Townsend; Mark M Davis; Christopher C Goodnow
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells.
Nature 1995;376(6536):181-4.
1995: R Brink; Christopher C Goodnow; Antony Basten
IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up-regulation CD80/CD86 co-stimulatory molecules.
European journal of immunology 1995;25(7):1980-4.
1995: Kevan M Shokat; Christopher C Goodnow
Antigen-induced B-cell death and elimination during germinal-centre immune responses.
Nature 1995;375(6529):334-8.
1995: Frances E Lund; N W Solvason; M P Cooke; A W Health; J C Grimaldi; R M Parkhouse; Christopher C Goodnow; MC Howard
Signaling through murine CD38 is impaired in antigen receptor-unresponsive B cells.
European journal of immunology 1995;25(5):1338-45.
1995: Jason G Cyster; Christopher C Goodnow
Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.
Immunity 1995;2(1):13-24.
1995: Christopher C Goodnow; Jason G Cyster; S B Hartley; S E Bell; M P Cooke; James I Healy; Srinivas Akkaraju; Jeffrey C Rathmell; S L Pogue; Kevan M Shokat
Self-tolerance checkpoints in B lymphocyte development.
Advances in immunology 1995;59():279-368.
1994: R Brink; D A Fulcher; Christopher C Goodnow; Antony Basten
Differential regulation of early and late stages of B lymphocyte development by the mu and delta membrane heavy chains of Ig.
International immunology 1994;6(12):1905-16.
1994: Jason G Cyster; S B Hartley; Christopher C Goodnow
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.
Nature 1994;371(6496):389-95.
1994: Jeffrey C Rathmell; Christopher C Goodnow
Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2831-42.
1994: D J Lenschow; Anne I Sperling; M P Cooke; Gordon J Freeman; L Rhee; D C Decker; G Gray; Lee M Nadler; Christopher C Goodnow; Jeffrey A Bluestone
Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):1990-7.
1994: W Y Ho; M P Cooke; Christopher C Goodnow; Mark M Davis
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.
The Journal of experimental medicine 1994;179(5):1539-49.
1994: S L Pogue; Christopher C Goodnow
Ig heavy chain extracellular spacer confers unique glycosylation of the Mb-1 component of the B cell antigen receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):3925-34.
1994: S E Bell; Christopher C Goodnow
A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.
The EMBO journal 1994;13(4):816-26.
1994: M P Cooke; A W Heath; Kevan M Shokat; Y Zeng; F D Finkelman; Peter Linsley; M Howard; Christopher C Goodnow
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.
The Journal of experimental medicine 1994;179(2):425-38.
1993: S B Hartley; M P Cooke; D A Fulcher; A W Harris; S Cory; A Basten; Christopher C Goodnow
Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.
Cell 1993;72(3):325-35.
1992: R Brink; Christopher C Goodnow; Jack Crosbie; E Adams; J Eris; D Y Mason; S B Hartley; Antony Basten
Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen.
The Journal of experimental medicine 1992;176(4):991-1005.
1992: Christopher C Goodnow
Safe havens for self-reactive cells.
Current biology : CB 1992;2(8):417-9.
1992: Christopher C Goodnow
Transgenic mice and analysis of B-cell tolerance.
Annual review of immunology 1992;10():489-518.
1991: S B Hartley; Jack Crosbie; R Brink; A B Kantor; Antony Basten; Christopher C Goodnow
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens.
Nature 1991;353(6346):765-9.
1991: Christopher C Goodnow; R Brink; E Adams
Breakdown of self-tolerance in anergic B lymphocytes.
Nature 1991;352(6335):532-6.
1991: Antony Basten; R Brink; P Peake; E Adams; Jack Crosbie; S Hartley; Christopher C Goodnow
Self tolerance in the B-cell repertoire.
Immunological reviews 1991;122():5-19.
1991: S Adelstein; H Pritchard-Briscoe; T A Anderson; Jack Crosbie; G Gammon; R H Loblay; Antony Basten; Christopher C Goodnow
Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen.
Science (New York, N.Y.) 1991;251(4998):1223-5.
1990: E Adams; Antony Basten; Christopher C Goodnow
Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5687-91.
1990: Christopher C Goodnow; S Adelstein; Antony Basten
The need for central and peripheral tolerance in the B cell repertoire.
Science (New York, N.Y.) 1990;248(4961):1373-9.
1989: Christopher C Goodnow
Cellular mechanisms of self-tolerance.
Current opinion in immunology 1989;2(2):226-36.
1989: Christopher C Goodnow; Jack Crosbie; H Jorgensen; R A Brink; Antony Basten
Induction of self-tolerance in mature peripheral B lymphocytes.
Nature 1989;342(6248):385-91.
1989: Christopher C Goodnow; Antony Basten
Self-tolerance in B lymphocytes.
Seminars in immunology 1989;1(2):125-35.
1989: Christopher C Goodnow; Jack Crosbie; S Adelstein; T B Lavoie; S J Smith-Gill; D Y Mason; H Jorgensen; R A Brink; H Pritchard-Briscoe; M Loughnan
Clonal silencing of self-reactive B lymphocytes in a transgenic mouse model.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():907-20.
1988: Christopher C Goodnow; Jack Crosbie; S Adelstein; T B Lavoie; S J Smith-Gill; R A Brink; H Pritchard-Briscoe; J S Wotherspoon; R H Loblay; K Raphael
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.
Nature 1988;334(6184):676-82.