Roger Goody

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Kulharia Mahesh; Bridgett Stephen J; Goody Roger S; Jackson Richard M
InCa-SiteFinder: a method for structure-based prediction of inositol and carbohydrate binding sites on proteins.
Wu Yao-Wen; Goody Roger S; Abagyan Ruben; Alexandrov Kirill
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation.
Nguyen Uyen T T; Guo Zhong; Delon Christine; Wu Yaowen; Deraeve Celine; Fränzel Benjamin; Bon Robin S; Blankenfeldt Wulf; Goody Roger S; Waldmann Herbert; Wolters Dirk; Alexandrov Kirill
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.

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All Publications

2009: Kulharia Mahesh; Bridgett Stephen J; Goody Roger S; Jackson Richard M
InCa-SiteFinder: a method for structure-based prediction of inositol and carbohydrate binding sites on proteins.
Journal of molecular graphics & modelling 2009;28(3):297-303.
2009: Wu Yao-Wen; Goody Roger S; Abagyan Ruben; Alexandrov Kirill
Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation.
The Journal of biological chemistry 2009;284(19):13185-92.
2009: Nguyen Uyen T T; Guo Zhong; Delon Christine; Wu Yaowen; Deraeve Celine; Fränzel Benjamin; Bon Robin S; Blankenfeldt Wulf; Goody Roger S; Waldmann Herbert; Wolters Dirk; Alexandrov Kirill
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.
Nature chemical biology 2009;5(4):227-35.
2009: Bergbrede Tim; Chuky Nam; Schoebel Stefan; Blankenfeldt Wulf; Geyer Matthias; Fuchs Evelyn; Goody Roger S; Barr Francis; Alexandrov Kirill
Biophysical analysis of the interaction of Rab6a GTPase with its effector domains.
The Journal of biological chemistry 2009;284(5):2628-35.
2008: Itzen Aymelt; Goody Roger S
Key determinants of Rab specificity.
Structure (London, England : 1993) 2008;16(10):1437-9.
2008: Kulharia Mahesh; Goody Roger S; Jackson Richard M
Information theory-based scoring function for the structure-based prediction of protein-ligand binding affinity.
Journal of chemical information and modeling 2008;48(10):1990-8.
2008: Guo Zhong; Wu Yao-Wen; Das Debapratim; Delon Christine; Cramer Janinna; Yu Shen; Thuns Sandra; Lupilova Nataliya; Waldmann Herbert; Brunsveld Luc; Goody Roger S; Alexandrov Kirill; Blankenfeldt Wulf
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
The EMBO journal 2008;27(18):2444-56.
2008: Mannherz Hans Georg; Ballweber Edda; Hegyi György; Goody Roger S
Cross-linked long-pitch actin dimer forms stoichiometric complexes with gelsolin segment 1 and/or deoxyribonuclease I that nonproductively interact with myosin subfragment 1.
Biochemistry 2008;47(35):9335-43.
2008: Ignatev Alexander; Kravchenko Sergey; Rak Alexey; Goody Roger S; Pylypenko Olena
A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism.
The Journal of biological chemistry 2008;283(26):18377-84.
2008: Pylypenko Olena; Schönichen André; Ludwig Diana; Ungermann Christian; Goody Roger S; Rak Alexey; Geyer Matthias
Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.
Journal of molecular biology 2008;377(5):1334-45.
2008: Guo Zhong; Wu Yao-Wen; Tan Kui-Thong; Bon Robin S; Guiu-Rozas Ester; Delon Christine; Nguyen T Uyen; Wetzel Stefan; Arndt Sabine; Goody Roger S; Blankenfeldt Wulf; Alexandrov Kirill; Waldmann Herbert
Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.
Angewandte Chemie (International ed. in English) 2008;47(20):3747-50.
2008: Milic Jelena; Seidel Ralf; Becker Christian F W; Goody Roger S; Engelhard Martin
Semisynthesis of H-Ras with a glutamic acid methylester at position 61.
Biopolymers 2008;90(3):399-405.
2007: Wu Yao-Wen; Tan Kui-Thong; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12294-9.
2007: Nguyen Uyen T T; Cramer Janina; Gomis Joaquin; Reents Reinhard; Gutierrez-Rodriguez Marta; Goody Roger S; Alexandrov Kirill; Waldmann Herbert
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization.
Chembiochem : a European journal of chemical biology 2007;8(4):408-23.
2007: Itzen Aymelt; Rak Alexey; Goody Roger S
Sec2 is a highly efficient exchange factor for the Rab protein Sec4.
Journal of molecular biology 2007;365(5):1359-67.
2007: Becker Christian F W; Marsac Yoann; Hazarika Pompi; Moser Jens; Goody Roger S; Niemeyer Christof M
Functional immobilization of the small GTPase Rab6A on DNA-Gold nanoparticles by using a site-specifically attached poly(ethylene glycol) linker and thiol place-exchange reaction.
Chembiochem : a European journal of chemical biology 2007;8(1):32-6.
2007: Budde Birgit S; Binner Priska; Waldmüller Stephan; Höhne Wolfgang; Blankenfeldt Wulf; Hassfeld Sabine; Brömsen Jürgen; Dermintzoglou Anastassia; Wieczorek Marcus; May Erik; Kirst Elisabeth; Selignow Carmen; Rackebrandt Kirsten; Müller Melanie; Goody Roger S; Vosberg Hans-Peter; Nürnberg Peter; Scheffold Thomas
Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene.
PloS one 2007;2(12):e1362.
2006: Wu Yao-Wen; Waldmann Herbert; Reents Reinhard; Ebetino Frank H; Goody Roger S; Alexandrov Kirill
A protein fluorescence amplifier: continuous fluorometric assay for rab geranylgeranyltransferase.
Chembiochem : a European journal of chemical biology 2006;7(12):1859-61.
2006: Brunsveld Luc; Kuhlmann Jürgen; Alexandrov Kirill; Wittinghofer Alfred; Goody Roger S; Waldmann Herbert
Lipidated ras and rab peptides and proteins--synthesis, structure, and function.
Angewandte Chemie (International ed. in English) 2006;45(40):6622-46.
2006: Kötting Carsten; Blessenohl Marco; Suveyzdis Yan; Goody Roger S; Wittinghofer Alfred; Gerwert Klaus
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):13911-6.
2006: Watzke Anja; Gutierrez-Rodriguez Marta; Köhn Maja; Wacker Ron; Schroeder Hendrik; Breinbauer Rolf; Kuhlmann Jürgen; Alexandrov Kirill; Niemeyer Christof M; Goody Roger S; Waldmann Herbert
A generic building block for C- and N-terminal protein-labeling and protein-immobilization.
Bioorganic & medicinal chemistry 2006;14(18):6288-306.
2006: Klink Björn U; Goody Roger S; Scheidig Axel J
A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction.
Biophysical journal 2006;91(3):981-92.
2006: Becker Christian F W; Seidel Ralf; Jahnz Michael; Bacia Kirsten; Niederhausen Thomas; Alexandrov Kirill; Schwille Petra; Goody Roger S; Engelhard Martin
C-terminal fluorescence labeling of proteins for interaction studies on the single-molecule level.
Chembiochem : a European journal of chemical biology 2006;7(6):891-5.
2006: Kushnir Susanna; Marsac Yoann; Breitling Reinhard; Granovsky Igor; Brok-Volchanskaya Vera; Goody Roger S; Becker Christian F W; Alexandrov Kirill
Rapid production of functionalized recombinant proteins: marrying ligation independent cloning and in vitro protein ligation.
Bioconjugate chemistry 2006;17(3):610-7.
2006: Itzen Aymelt; Pylypenko Olena; Goody Roger S; Alexandrov Kirill; Rak Alexey
Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.
The EMBO journal 2006;25(7):1445-55.
2006: Dursina Beatrice; Reents Reinhard; Delon Christine; Wu Yaowen; Kulharia Mahesh; Thutewohl Michael; Veligodsky Alexei; Kalinin Alexandr; Evstifeev Vladimir; Ciobanu Doina; Szedlacsek Stefan E; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.
Journal of the American Chemical Society 2006;128(9):2822-35.
2006: Watzke Anja; Köhn Maja; Gutierrez-Rodriguez Marta; Wacker Ron; Schröder Hendrik; Breinbauer Rolf; Kuhlmann Jürgen; Alexandrov Kirill; Niemeyer Christof M; Goody Roger S; Waldmann Herbert
Site-selective protein immobilization by Staudinger ligation.
Angewandte Chemie (International ed. in English) 2006;45(9):1408-12.
2006: Pylypenko Olena; Rak Alexey; Durek Thomas; Kushnir Susanna; Dursina Beatrice E; Thomae Nicolas H; Constantinescu Alexandru T; Brunsveld Luc; Watzke Anja; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling.
The EMBO journal 2006;25(1):13-23.
2005: Eberth Alexander; Dvorsky Radovan; Becker Christian F W; Beste Andrea; Goody Roger S; Ahmadian Mohammad Reza
Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins.
Biological chemistry 2005;386(11):1105-14.
2005: Guo Zhong; Ahmadian Mohammad Reza; Goody Roger S
Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism.
Biochemistry 2005;44(47):15423-9.
2005: Becker Christian F W; Wacker Ron; Bouschen Werner; Seidel Ralf; Kolaric Branko; Lang Pascal; Schroeder Hendrick; Müller Oliver; Niemeyer Christof M; Spengler Bernhard; Goody Roger S; Engelhard Martin
Direct readout of protein-protein interactions by mass spectrometry from protein-DNA microarrays.
Angewandte Chemie (International ed. in English) 2005;44(46):7635-9.
2005: Goody R S; Rak A; Alexandrov K
The structural and mechanistic basis for recycling of Rab proteins between membrane compartments.
Cellular and molecular life sciences : CMLS 2005;62(15):1657-70.
2005: Phillips Robert S; Miles Edith W; Holtermann Georg; Goody Roger S
Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase.
Biochemistry 2005;44(21):7921-8.
2005: Watzke Anja; Brunsveld Luc; Durek Thomas; Alexandrov Kirill; Rak Alexey; Goody Roger S; Waldmann Herbert
Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases.
Organic & biomolecular chemistry 2005;3(7):1157-64.
2005: Brunsveld Luc; Watzke Anja; Durek Thomas; Alexandrov Kirill; Goody Roger S; Waldmann Herbert
Synthesis of functionalized rab GTPases by a combination of solution- or solid-phase lipopeptide synthesis with expressed protein ligation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(9):2756-72.
2005: Wöhrl Birgitta M; Loubière Laurence; Brundiers Ralf; Goody Roger S; Klatzmann David; Konrad Manfred
Expressing engineered thymidylate kinase variants in human cells to improve AZT phosphorylation and human immunodeficiency virus inhibition.
The Journal of general virology 2005;86(Pt 3):757-64.
2005: Dursina Beatrice-Elena; Reents Reinhard; Niculae Anca; Veligodsky Alexei; Breitling Reinhard; Pyatkov Konstantin; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
A genetically encodable microtag for chemo-enzymatic derivatization and purification of recombinant proteins.
Protein expression and purification 2005;39(1):71-81.
2005: Goody Roger S; Durek Thomas; Waldmann Herbert; Brunsveld Lucas; Alexandrov Kirill
Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases.
Methods in enzymology 2005;403():29-42.
2004: Durek Thomas; Alexandrov Kirill; Goody Roger S; Hildebrand Alexandra; Heinemann Ines; Waldmann Herbert
Synthesis of fluorescently labeled mono- and diprenylated Rab7 GTPase.
Journal of the American Chemical Society 2004;126(50):16368-78.
2004: Rak Alexey; Pylypenko Olena; Niculae Anca; Pyatkov Konstantin; Goody Roger S; Alexandrov Kirill
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.
Cell 2004;117(6):749-60.
2004: Durek Thomas; Goody Roger S; Alexandrov Kirill
In vitro semisynthesis and applications of C-terminally modified rab proteins.
Methods in molecular biology (Clifton, N.J.) 2004;283():233-44.
2003: Rak Alexey; Pylypenko Olena; Durek Thomas; Watzke Anja; Kushnir Susanna; Brunsveld Lucas; Waldmann Herbert; Goody Roger S; Alexandrov Kirill
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase.
Science (New York, N.Y.) 2003;302(5645):646-50.
2003: Goody Roger S
The missing link in the muscle cross-bridge cycle.
Nature structural biology 2003;10(10):773-5.
2003: Lovrinovic Marina; Seidel Ralf; Wacker Ron; Schroeder Hendrik; Seitz Oliver; Engelhard Martin; Goody Roger S; Niemeyer Christof M
Synthesis of protein-nucleic acid conjugates by expressed protein ligation.
Chemical communications (Cambridge, England) 2003;(7):822-3.
2003: Becker Christian F W; Hunter Christie L; Seidel Ralf; Kent Stephen B H; Goody Roger S; Engelhard Martin
Total chemical synthesis of a functional interacting protein pair: the protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5075-80.
2003: Pylypenko Olena; Rak Alexey; Reents Reinhard; Niculae Anca; Sidorovitch Vadim; Cioaca Maria Daniela; Bessolitsyna Ekaterina; Thomä Nicolas H; Waldmann Herbert; Schlichting Ilme; Goody Roger S; Alexandrov Kirill
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Molecular cell 2003;11(2):483-94.
2003: Rothwell P J; Berger S; Kensch O; Felekyan S; Antonik M; Wöhrl B M; Restle T; Goody R S; Seidel C A M
Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1655-60.
2003: Rak Alexey; Pylypenko Olena; Niculae Anca; Goody Roger S; Alexandrov Kirill
Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1.
Journal of structural biology 2003;141(1):93-5.
2003: Goody Roger S
The significance of the free energy of hydrolysis of GTP for signal-transducing and regulatory GTPases.
Biophysical chemistry 2003;100(1-3):535-44.
2002: Kraemer Astrid; Brinkmann Thilo; Plettner Ina; Goody Roger; Wittinghofer Alfred
Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions.
Journal of molecular biology 2002;324(4):763-74.
2002: Goody Roger S; Hofmann-Goody Waltraud
Exchange factors, effectors, GAPs and motor proteins: common thermodynamic and kinetic principles for different functions.
European biophysics journal : EBJ 2002;31(4):268-74.
2002: Rak Alexey; Niculae Anca; Kalinin Alexandr; Thomä Nicolas H; Sidorovitch Vadim; Goody Roger S; Alexandrov Kirill
In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex.
Protein expression and purification 2002;25(1):23-30.
2002: Dursina Beatrice; Thomä Nicolas H; Sidorovitch Vadim; Niculae Anca; Iakovenko Andrei; Rak Alexy; Albert Stefan; Ceacareanu Alice-Corina; Kölling Ralf; Herrmann Christian; Goody Roger S; Alexandrov Kirill
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates.
Biochemistry 2002;41(21):6805-16.
2002: Alexandrov Kirill; Heinemann Ines; Durek Thomas; Sidorovitch Vadim; Goody Roger S; Waldmann Herbert
Intein-mediated synthesis of geranylgeranylated Rab7 protein in vitro.
Journal of the American Chemical Society 2002;124(20):5648-9.
2002: Goody Roger S; Alexandrov Kirill; Engelhard Martin
Combining chemical and biological techniques to produce modified proteins.
Chembiochem : a European journal of chemical biology 2002;3(5):399-403.
2002: Constantinescu Alexandru-Tudor; Rak Alexey; Alexandrov Kirill; Esters Heike; Goody Roger S; Scheidig Axel J
Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases.
Structure (London, England : 1993) 2002;10(4):569-79.
2001: Thomä N H; Iakovenko A; Goody R S; Alexandrov K
Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.
The Journal of biological chemistry 2001;276(52):48637-43.
2001: Thomä N H; Niculae A; Goody R S; Alexandrov K
Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate.
The Journal of biological chemistry 2001;276(52):48631-6.
2001: Rak A; Reents R; Pylypenko O; Niculae A; Sidorovitch V; Thomä N H; Waldmann H; Schlichting I; Goody R S; Alexandrov K
Crystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Journal of structural biology 2001;136(2):158-61.
2001: Esters H; Alexandrov K; Iakovenko A; Ivanova T; Thomä N; Rybin V; Zerial M; Scheidig A J; Goody R S
Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins.
Journal of molecular biology 2001;310(1):141-56.
2001: Becker C F; Hunter C L; Seidel R P; Kent S B; Goody R S; Engelhard M
A sensitive fluorescence monitor for the detection of activated Ras: total chemical synthesis of site-specifically labeled Ras binding domain of c-Raf1 immobilized on a surface.
Chemistry & biology 2001;8(3):243-52.
2001: Goedecke K; Pignot M; Goody R S; Scheidig A J; Weinhold E
Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog.
Nature structural biology 2001;8(2):121-5.
2001: Thomä N H; Iakovenko A; Kalinin A; Waldmann H; Goody R S; Alexandrov K
Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II.
Biochemistry 2001;40(1):268-74.
2001: Alexandrov K; Scheidig A J; Goody R S
Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase.
Methods in enzymology 2001;329():14-31.
2000: Ostermann N; Lavie A; Padiyar S; Brundiers R; Veit T; Reinstein J; Goody R S; Konrad M; Schlichting I
Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP.
Journal of molecular biology 2000;304(1):43-53.
2000: Rak A; Fedorov R; Alexandrov K; Albert S; Goody R S; Gallwitz D; Scheidig A J
Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins.
The EMBO journal 2000;19(19):5105-13.
2000: Thomä N H; Iakovenko A; Owen D; Scheidig A S; Waldmann H; Goody R S; Alexandrov K
Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II.
Biochemistry 2000;39(39):12043-52.
2000: Kensch O; Restle T; Wöhrl B M; Goody R S; Steinhoff H J
Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of HIV-1 reverse transcriptase revealed by site-directed spin labelling.
Journal of molecular biology 2000;301(4):1029-39.
2000: Ostermann N; Schlichting I; Brundiers R; Konrad M; Reinstein J; Veit T; Goody R S; Lavie A
Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate.
Structure (London, England : 1993) 2000;8(6):629-42.
2000: Kensch O; Connolly B A; Steinhoff H J; McGregor A; Goody R S; Restle T
HIV-1 reverse transcriptase-pseudoknot RNA aptamer interaction has a binding affinity in the low picomolar range coupled with high specificity.
The Journal of biological chemistry 2000;275(24):18271-8.
2000: Esters H; Alexandrov K; Constantinescu A T; Goody R S; Scheidig A J
High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis.
Journal of molecular biology 2000;298(1):111-21.
2000: Iakovenko A; Rostkova E; Merzlyak E; Hillebrand A M; Thomä N H; Goody R S; Alexandrov K
Semi-synthetic Rab proteins as tools for studying intermolecular interactions.
FEBS letters 2000;468(2-3):155-8.
1999: Brundiers R; Lavie A; Veit T; Reinstein J; Schlichting I; Ostermann N; Goody R S; Konrad M
Modifying human thymidylate kinase to potentiate azidothymidine activation.
The Journal of biological chemistry 1999;274(50):35289-92.
1999: Gruen M; Becker C; Beste A; Reinstein J; Scheidig A J; Goody R S
2'Halo-ATP and -GTP analogues: rational phasing tools for protein crystallography.
Protein science : a publication of the Protein Society 1999;8(11):2524-8.
1999: Scheidig A J; Burmester C; Goody R S
The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.
Structure (London, England : 1993) 1999;7(11):1311-24.
1999: Alexandrov K; Simon I; Yurchenko V; Iakovenko A; Rostkova E; Scheidig A J; Goody R S
Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.
European journal of biochemistry / FEBS 1999;265(1):160-70.
1999: Wöhrl B M; Krebs R; Goody R S; Restle T
Refined model for primer/template binding by HIV-1 reverse transcriptase: pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nucleic acid substrate.
Journal of molecular biology 1999;292(2):333-44.
1999: Sydor J R; Herrmann C; Kent S B; Goody R S; Engelhard M
Design, total chemical synthesis, and binding properties of a [Leu-91-N1-methyl-7-azaTrp]Ras-binding domain of c-Raf-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7865-70.
1999: Sydor J R; Seidel R P; Goody R S; Engelhard M
Cell-free synthesis of the Ras-binding domain of c-Raf-1: binding studies to fluorescently labelled H-ras.
FEBS letters 1999;452(3):375-8.
1998: Lavie A; Ostermann N; Brundiers R; Goody R S; Reinstein J; Konrad M; Schlichting I
Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14045-50.
1998: Sydor J R; Engelhard M; Wittinghofer A; Goody R S; Herrmann C
Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex.
Biochemistry 1998;37(40):14292-9.
1998: Thrall S H; Krebs R; Wöhrl B M; Cellai L; Goody R S; Restle T
Pre-steady-state kinetic characterization of RNA-primed initiation of transcription by HIV-1 reverse transcriptase and analysis of the transition to a processive DNA-primed polymerization mode.
Biochemistry 1998;37(38):13349-58.
1998: Souquet M; Restle T; Krebs R; Le Grice S F; Goody R S; Wöhrl B M
Analysis of the polymerization kinetics of homodimeric EIAV p51/51 reverse transcriptase implies the formation of a polymerase active site identical to heterodimeric EIAV p66/51 reverse transcriptase.
Biochemistry 1998;37(35):12144-52.
1998: Cepus V; Scheidig A J; Goody R S; Gerwert K
Time-resolved FTIR studies of the GTPase reaction of H-ras p21 reveal a key role for the beta-phosphate.
Biochemistry 1998;37(28):10263-71.
1998: Alexandrov K; Simon I; Iakovenko A; Holz B; Goody R S; Scheidig A J
Moderate discrimination of REP-1 between Rab7 x GDP and Rab7 x GTP arises from a difference of an order of magnitude in dissociation rates.
FEBS letters 1998;425(3):460-4.
1998: Lavie A; Konrad M; Brundiers R; Goody R S; Schlichting I; Reinstein J
Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
Biochemistry 1998;37(11):3677-86.
1998: Scheidig A J; Burmester C; Goody R S
Use of caged nucleotides to characterize unstable intermediates by X-ray crystallography.
Methods in enzymology 1998;291():251-64.
1997: Lavie A; Schlichting I; Vetter I R; Konrad M; Reinstein J; Goody R S
The bottleneck in AZT activation.
Nature medicine 1997;3(8):922-4.
1997: Krebs R; Immendörfer U; Thrall S H; Wöhrl B M; Goody R S
Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.
Biochemistry 1997;36(33):10292-300.
1997: Wöhrl B M; Krebs R; Thrall S H; Le Grice S F; Scheidig A J; Goody R S
Kinetic analysis of four HIV-1 reverse transcriptase enzymes mutated in the primer grip region of p66. Implications for DNA synthesis and dimerization.
The Journal of biological chemistry 1997;272(28):17581-7.
1997: Ahmadian M R; Hoffmann U; Goody R S; Wittinghofer A
Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy.
Biochemistry 1997;36(15):4535-41.
1997: Packschies L; Theyssen H; Buchberger A; Bukau B; Goody R S; Reinstein J
GrpE accelerates nucleotide exchange of the molecular chaperone DnaK with an associative displacement mechanism.
Biochemistry 1997;36(12):3417-22.
1997: Schlichting I; Goody R S
Triggering methods in crystallographic enzyme kinetics.
Methods in enzymology 1997;277():467-90.
1996: Arts E J; Stetor S R; Li X; Rausch J W; Howard K J; Ehresmann B; North T W; Wöhrl B M; Goody R S; Wainberg M A; Grice S F
Initiation of (-) strand DNA synthesis from tRNA(3Lys) on lentiviral RNAs: implications of specific HIV-1 RNA-tRNA(3Lys) interactions inhibiting primer utilization by retroviral reverse transcriptases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10063-8.
1996: Simon I; Zerial M; Goody R S
Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions.
The Journal of biological chemistry 1996;271(34):20470-8.
1996: Mittal R; Ahmadian M R; Goody R S; Wittinghofer A
Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins.
Science (New York, N.Y.) 1996;273(5271):115-7.
1996: Rittinger K; Negre D; Divita G; Scarabel M; Bonod-Bidaud C; Goody R S; Cozzone A J; Cortay J C
Escherichia coli isocitrate dehydrogenase kinase/phosphatase. Overproduction and kinetics of interaction with its substrates by using intrinsic fluorescence and fluorescent nucleotide analogues.
European journal of biochemistry / FEBS 1996;237(1):247-54.
1996: Thrall S H; Reinstein J; Wöhrl B M; Goody R S
Evaluation of human immunodeficiency virus type 1 reverse transcriptase primer tRNA binding by fluorescence spectroscopy: specificity and comparison to primer/template binding.
Biochemistry 1996;35(14):4609-18.
1996: Schmidt G; Lenzen C; Simon I; Deuter R; Cool R H; Goody R S; Wittinghofer A
Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides.
Oncogene 1996;12(1):87-96.
1995: Divita G; Rittinger K; Restle T; Immendörfer U; Goody R S
Conformational stability of dimeric HIV-1 and HIV-2 reverse transcriptases.
Biochemistry 1995;34(50):16337-46.
1995: Divita G; Baillon J G; Rittinger K; Chermann J C; Goody R S
Interface peptides as structure-based human immunodeficiency virus reverse transcriptase inhibitors.
The Journal of biological chemistry 1995;270(48):28642-6.
1995: Klebe C; Prinz H; Wittinghofer A; Goody R S
The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1.
Biochemistry 1995;34(39):12543-52.
1995: Scheidig A J; Franken S M; Corrie J E; Reid G P; Wittinghofer A; Pai E F; Goody R S
X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
Journal of molecular biology 1995;253(1):132-50.
1995: Rittinger K; Divita G; Goody R S
Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):8046-9.
1995: Goody R S
Rational drug design and HIV: hopes and limitations.
Nature medicine 1995;1(6):519-20.
1995: Wiesmüller L; Scheffzek K; Kliche W; Goody R S; Wittinghofer A; Reinstein J
Crystallization and preliminary X-ray analysis of UMP/CMP-kinase from Dictyostelium discoideum with the specific bisubstrate inhibitor P1-(adenosine 5')-P5-(uridine 5')-pentaphosphate (UP5A).
FEBS letters 1995;363(1-2):22-4.
1995: Divita G; Rittinger K; Geourjon C; Deléage G; Goody R S
Dimerization kinetics of HIV-1 and HIV-2 reverse transcriptase: a two step process.
Journal of molecular biology 1995;245(5):508-21.
1995: Rensland H; John J; Linke R; Simon I; Schlichting I; Wittinghofer A; Goody R S
Substrate and product structural requirements for binding of nucleotides to H-ras p21: the mechanism of discrimination between guanosine and adenosine nucleotides.
Biochemistry 1995;34(2):593-9.
1994: Scheffzek K; Kabsch W; Schlichting I; Pai E F; Lautwein A; Frech M; Wittinghoffer A; Goody R S
Crystallization and preliminary X-ray structure analysis of thermally unstable p21(H-ras) guanosine complexes.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):521-6.
1994: Scheidig A J; Sanchez-Llorente A; Lautwein A; Pai E F; Corrie J E; Reid G P; Wittinghofer A; Goody R S
Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):512-20.
1994: Divita G; Restle T; Goody R S; Chermann J C; Baillon J G
Inhibition of human immunodeficiency virus type 1 reverse transcriptase dimerization using synthetic peptides derived from the connection domain.
The Journal of biological chemistry 1994;269(18):13080-3.
1993: Khan S; Castellano F; Spudich J L; McCray J A; Goody R S; Reid G P; Trentham D R
Excitatory signaling in bacterial probed by caged chemoeffectors.
Biophysical journal 1993;65(6):2368-82.
1993: Falson P; Penin F; Divita G; Lavergne J P; Di Pietro A; Goody R S; Gautheron D C
Functional nucleotide-binding domain in the F0F1-ATPsynthase alpha subunit from the yeast Schizosaccharomyces pombe.
Biochemistry 1993;32(39):10387-97.
1993: Franken S M; Scheidig A J; Krengel U; Rensland H; Lautwein A; Geyer M; Scheffzek K; Goody R S; Kalbitzer H R; Pai E F
Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry 1993;32(33):8411-20.
1993: Divita G; Müller B; Immendörfer U; Gautel M; Rittinger K; Restle T; Goody R S
Kinetics of interaction of HIV reverse transcriptase with primer/template.
Biochemistry 1993;32(31):7966-71.
1993: Divita G; Goody R S; Gautheron D C; Di Pietro A
Structural mapping of catalytic site with respect to alpha-subunit and noncatalytic site in yeast mitochondrial F1-ATPase using fluorescence resonance energy transfer.
The Journal of biological chemistry 1993;268(18):13178-86.
1993: Divita G; Restle T; Goody R S
Characterization of the dimerization process of HIV-1 reverse transcriptase heterodimer using intrinsic protein fluorescence.
FEBS letters 1993;324(2):153-8.
1993: John J; Rensland H; Schlichting I; Vetter I; Borasio G D; Goody R S; Wittinghofer A
Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.
The Journal of biological chemistry 1993;268(2):923-9.
1993: Wittinghofer A; Franken S M; Scheidig A J; Rensland H; Lautwein A; Pai E F; Goody R S
Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21.
Ciba Foundation symposium 1993;176():6-21; discussion 21-7.
1992: Kalbitzer H R; Rohr G; Nowak E; Goody R S; Kuhn W; Zimmermann H
A new high sensitivity 19F probe for labeling cysteine groups of proteins.
NMR in biomedicine 1992;5(6):347-50.
1992: Restle T; Pawlita M; Sczakiel G; Müller B; Goody R S
Structure-function relationships of HIV-1 reverse transcriptase determined using monoclonal antibodies.
The Journal of biological chemistry 1992;267(21):14654-61.
1992: Goody R S; Pai E F; Schlichting I; Rensland H; Scheidig A; Franken S; Wittinghofer A
Studies on the structure and mechanism of H-ras p21.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1992;336(1276):3-10; discussion 10-1.
1992: Restle T; Müller B; Goody R S
RNase H activity of HIV reverse transcriptases is confined exclusively to the dimeric forms.
FEBS letters 1992;300(1):97-100.
1991: Rensland H; Lautwein A; Wittinghofer A; Goody R S
Is there a rate-limiting step before GTP cleavage by H-ras p21?
Biochemistry 1991;30(46):11181-5.
1991: Goody R S; Müller B; Restle T
Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo.
FEBS letters 1991;291(1):1-5.
1991: Reinstein J; Schlichting I; Frech M; Goody R S; Wittinghofer A
p21 with a phenylalanine 28----leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties.
The Journal of biological chemistry 1991;266(26):17700-6.
1991: Müller B; Restle T; Kühnel H; Goody R S
Expression of the heterodimeric form of human immunodeficiency virus type 2 reverse transcriptase in Escherichia coli and characterization of the enzyme.
The Journal of biological chemistry 1991;266(22):14709-13.
1991: Ménétret J F; Hofmann W; Schröder R R; Rapp G; Goody R S
Time-resolved cryo-electron microscopic study of the dissociation of actomyosin induced by photolysis of photolabile nucleotides.
Journal of molecular biology 1991;219(2):139-44.
1991: Rapp G; Güth K; Maeda Y; Poole K J; Goody R S
Time-resolved X-ray diffraction studies on stretch-activated insect flight muscle.
Journal of muscle research and cell motility 1991;12(2):208-15.
1991: Müller B; Restle T; Reinstein J; Goody R S
Interaction of fluorescently labeled dideoxynucleotides with HIV-1 reverse transcriptase.
Biochemistry 1991;30(15):3709-15.
1991: Poole K J; Maeda Y; Rapp G; Goody R S
Dynamic X-ray diffraction measurements following photolytic relaxation and activation of skinned rabbit psoas fibres.
Advances in biophysics 1991;27():63-75.
1990: Reinstein J; Vetter I R; Schlichting I; Rösch P; Wittinghofer A; Goody R S
Fluorescence and NMR investigations on the ligand binding properties of adenylate kinases.
Biochemistry 1990;29(32):7440-50.
1990: Pai E F; Krengel U; Petsko G A; Goody R S; Kabsch W; Wittinghofer A
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
The EMBO journal 1990;9(8):2351-9.
1990: John J; Sohmen R; Feuerstein J; Linke R; Wittinghofer A; Goody R S
Kinetics of interaction of nucleotides with nucleotide-free H-ras p21.
Biochemistry 1990;29(25):6058-65.
1990: Restle T; Müller B; Goody R S
Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.
The Journal of biological chemistry 1990;265(16):8986-8.
1990: Kalbitzer H R; Feuerstein J; Goody R S; Wittinghofer A
Stereochemistry and lifetime of the GTP hydrolysis intermediate at the active site of elongation factor Tu from Bacillus stearothermophilus as inferred from the 17O-55Mn superhyperfine interaction.
European journal of biochemistry / FEBS 1990;188(2):355-9.
1989: Schlichting I; Rapp G; John J; Wittinghofer A; Pai E F; Goody R S
Biochemical and crystallographic characterization of a complex of c-Ha-ras p21 and caged GTP with flash photolysis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7687-90.
1989: Müller B; Restle T; Weiss S; Gautel M; Sczakiel G; Goody R S
Co-expression of the subunits of the heterodimer of HIV-1 reverse transcriptase in Escherichia coli.
The Journal of biological chemistry 1989;264(24):13975-8.
1989: Rösch P; Klaus W; Auer M; Goody R S
Nucleotide and AP5A complexes of porcine adenylate kinase: A 1H and 19F NMR study.
Biochemistry 1989;28(10):4318-25.
1989: Feuerstein J; Goody R S; Webb M R
The mechanism of guanosine nucleotide hydrolysis by p21 c-Ha-ras. The stereochemical course of the GTPase reaction.
The Journal of biological chemistry 1989;264(11):6188-90.
1988: Nowak E; Strzelecka-Golaszewska H; Goody R S
Kinetics of nucleotide and metal ion interaction with G-actin.
Biochemistry 1988;27(5):1785-92.
1988: Wray J S; Goody R S; Holmes K C
Towards a molecular mechanism for the crossbridge cycle.
Advances in experimental medicine and biology 1988;226():49-59.
1988: Poole K J; Rapp G; Maéda Y; Goody R S
The time course of changes in the equatorial diffraction patterns from different muscle types on photolysis of caged-ATP.
Advances in experimental medicine and biology 1988;226():391-404.
1987: Feuerstein J; Kalbitzer H R; John J; Goody R S; Wittinghofer A
Characterisation of the metal-ion-GDP complex at the active sites of transforming and nontransforming p21 proteins by observation of the 17O-Mn superhyperfine coupling and by kinetic methods.
European journal of biochemistry / FEBS 1987;162(1):49-55.

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