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Jean-François Goossens

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TOP 3
Florence Bourdon; Thierry Dine; Nicolas Kambia; Nicolas Lebegue; Marie Lecoeur; Claude Vaccher; Valérie Verones; Jean-François Goossens
In vitro pharmacokinetic profile of a benzopyridooxathiazepine derivative using rat microsomes and hepatocytes: Identification of phases I and II metabolites.
Thomas Queruau Lamerie; Pascal Bonnabry; Bertrand Décaudin; Sandrine Fleury-Souverain; Jean-François Goossens; Susanne Nussbaumer; Pascal Odou
Evaluation of decontamination efficacy of cleaning solutions on stainless steel and glass surfaces contaminated by 10 antineoplastic agents.
Tiphaine Rogez-Florent; Andrea Scozzafava; Perrine Six; Claudiu T Supuran; Christine Bal-Mahieu; Patrick Depreux; Catherine Foulon; Raphaël Frédérick; Sébastien Gluszok; Jean-François Goossens; Abigaëlle Gros; Amélie Lansiaux; Bernard Masereel; Samuel Meignan; Laurence Goossens
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.

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All Publications

2013: Florence Bourdon; Thierry Dine; Nicolas Kambia; Nicolas Lebegue; Marie Lecoeur; Claude Vaccher; Valérie Verones; Jean-François Goossens
In vitro pharmacokinetic profile of a benzopyridooxathiazepine derivative using rat microsomes and hepatocytes: Identification of phases I and II metabolites.
Journal of pharmaceutical and biomedical analysis 2013;80():69-78.
2013: Thomas Queruau Lamerie; Pascal Bonnabry; Bertrand Décaudin; Sandrine Fleury-Souverain; Jean-François Goossens; Susanne Nussbaumer; Pascal Odou
Evaluation of decontamination efficacy of cleaning solutions on stainless steel and glass surfaces contaminated by 10 antineoplastic agents.
The Annals of occupational hygiene 2013;57(4):456-69.
2013: Tiphaine Rogez-Florent; Andrea Scozzafava; Perrine Six; Claudiu T Supuran; Christine Bal-Mahieu; Patrick Depreux; Catherine Foulon; Raphaël Frédérick; Sébastien Gluszok; Jean-François Goossens; Abigaëlle Gros; Amélie Lansiaux; Bernard Masereel; Samuel Meignan; Laurence Goossens
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.
Bioorganic & medicinal chemistry 2013;21(6):1451-64.
2013: Valérie Verones; Nicole Wattez; Marie Lecoeur; Amelie Lemoine; Christine Mahieu; Brigitte Baldeyrou; Pascal Berthelot; Amaury Farce; Nathalie Flouquet; Jean-François Goossens; Amélie Lansiaux; Nicolas Lebegue
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives.
European journal of medicinal chemistry 2013;59():39-47.
2012: Thomas Queruau Lamerie; Christine Barthélémy; Pascal Bonnabry; Lucie Bouchoud; Laurent Carrez; Bertrand Décaudin; Jean-François Goossens; Pascal Odou
Multiple-test assessment of devices to protect healthcare workers when administering cytotoxic drugs to patients.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2012;18(2):191-200.
2011: Marie Lecoeur; Claude Vaccher; Jean-Paul Bonte; Jean-François Goossens; Catherine Foulon
A multivariate approach for the determination of isoelectric point of human carbonic anhydrase isoforms by capillary isoelectric focusing.
Electrophoresis 2011;32(20):2857-66.
2011: Eric Stern; Laurence Goossens; Pascal Retailleau; Brice Kauffmann; Jean-Paul Bonte; Patrick Depreux; Jean-François Goossens
Preparative enantiomeric separation of new selective CB2 receptor agonists by liquid chromatography on polysaccharide-based chiral stationary phases: determination of enantiomeric purity and assignment of absolute stereochemistry by X-ray structure analysis.
Chirality 2011;23(5):389-96.
2009: Catherine Foulon; J Tedou; S Peyrottes; C Perigaud; Jean-Paul Bonte; Claude Vaccher; Jean-François Goossens
Separation of diastereoisomers of Ara-C phosphotriesters using solid phase extraction and HPLC for the study of their decomposition kinetic in cell extracts.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(29):3475-81.
2008: Jean-François Goossens; S Roux; D Egron; C Perigaud; Jean-Paul Bonte; Claude Vaccher; Catherine Foulon
Separation of nucleoside phosphoramidate diastereoisomers by high performance liquid chromatography and capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;875(1):288-95.
2008: E Stern; Laurence Goossens; C Vaccher; J-P Bonte; Patrick Depreux; Jean-Pierre Henichart; Jean-François Goossens
Chiral resolution of the enantiomers of new selective CB(2) receptor agonists by liquid chromatography on amylose stationary phases.
Journal of pharmaceutical and biomedical analysis 2008;46(5):848-53.
2007: Eric Stern; Giulio G Muccioli; Barbara Bosier; Laurie Hamtiaux; Régis Millet; Jacques H Poupaert; Jean-Pierre Hénichart; Patrick Depreux; Jean-François Goossens; Didier M Lambert
Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality.
Journal of medicinal chemistry 2007;50(22):5471-84.
2007: Pauline Gilleron; Nicolas Wlodarczyk; Raymond Houssin; Amaury Farce; Guillaume Laconde; Jean-François Goossens; Amélie Lemoine; Nicole Pommery; Jean-Pierre Hénichart; Régis Millet
Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(19):5465-71.
2007: Catherine Foulon; Nathalie Duhal; B Lacroix-Callens; Claude Vaccher; Jean-Paul Bonte; Jean-François Goossens
Determination of pKa values of benzoxa-, benzothia- and benzoselena-zolinone derivatives by capillary electrophoresis. Comparison with potentiometric titration and spectrometric data.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2007;31(3-4):165-71.
2006: Jean-François Goossens; Christine Mahieu; Nathalie Dias; Christian Bailly; Paola Principe; Jean-Paul Bonte; Amélie Lansiaux; Claude Vaccher; Catherine Foulon
Chiral capillary electrophoretic determination of the enantiomeric purity of homocamptothecin derivatives, promising antitumor topoisomerase I inhibitors, using highly sulfated CDs and fluorescence detection.
Electrophoresis 2006;27(23):4717-29.
2006: Catherine Foulon; Claude Vaccher; A-L Villard; JY Puy; Isabelle Lefebvre; C Perigaud; Jean-Paul Bonte; Jean-François Goossens
Diastereoisomeric resolution of a pronucleotide using solid phase extraction and high performance liquid chromatography: application to a stereoselective decomposition kinetic in cell extracts.
Journal of pharmaceutical and biomedical analysis 2006;42(2):245-52.
2006: Pauline Gilleron; Régis Millet; Raymond Houssin; Nicolas Wlodarczyk; Amaury Farce; Amélie Lemoine; Jean-François Goossens; Philippe CHAVATTE; Nicole Pommery; Jean-Pierre Hénichart
Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.
European journal of medicinal chemistry 2006;41(6):745-55.
2006: Eric Stern; Giulio G Muccioli; Régis Millet; Jean-François Goossens; Amaury Farce; Philippe CHAVATTE; Jacques H Poupaert; Didier M Lambert; Patrick Depreux; Jean-Pierre Hénichart
Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.
Journal of medicinal chemistry 2006;49(1):70-9.
2005: Nathalie Dias; Ulrich Jacquemard; Brigitte Baldeyrou; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Sylvain Routier; Jean-Yves Mérour
Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties.
European journal of medicinal chemistry 2005;40(12):1206-13.
2005: Ulrich Jacquemard; Sylvain Routier; Nathalie Dias; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Jean-Yves Mérour
Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity.
European journal of medicinal chemistry 2005;40(11):1087-95.
2005: Cécile Danel; Emmanuelle Lipka; Jean-Paul Bonte; Jean-François Goossens; Claude Vaccher; Catherine Foulon
Enantioseparation of chiral N-imidazole derivatives by electrokinetic chromatography using highly sulfated cyclodextrins: mechanism of enantioselective recognition.
Electrophoresis 2005;26(20):3824-32.
2005: Marie-Pierre Vaccher; Emmanuelle Lipka; Jean-Paul Bonte; Catherine Foulon; Jean-François Goossens; Claude Vaccher
Enantiomeric analysis of baclofen analogs by capillary zone electrophoresis, using highly sulfated cyclodextrins: Inclusion ionization constant pKa determination.
Electrophoresis 2005;26(15):2974-83.
2005: Jean-François Goossens; Catherine Foulon; A-L Villard; JY Puy; Isabelle Lefebvre; C Perigaud; Claude Vaccher; Jean-Paul Bonte
Column selection and method development for the separation of nucleoside phosphotriester diastereoisomers, new potential anti-viral drugs. Application to cellular extract analysis.
Biomedical chromatography : BMC 2005;19(6):415-25.
2005: Nathalie Dias; Jean-François Goossens; Brigitte Baldeyrou; Amélie Lansiaux; Pierre Colson; Alberto Di Salvo; Jeanne Bernal; Agnes Turnbull; David J Mincher; Christian Bailly
Oxoazabenzo[de]anthracenes conjugated to amino acids: synthesis and evaluation as DNA-binding antitumor agents.
Bioconjugate chemistry 2005;16(4):949-58.
2005: Steve Lancel; Olivier Joulin; Raphael Favory; Jean-François Goossens; jerome kluza; Claude Chopin; Pierre Formstecher; Philippe MARCHETTI; Remi Neviere
Ventricular myocyte caspases are directly responsible for endotoxin-induced cardiac dysfunction.
Circulation 2005;111(20):2596-604.
2005: Laurence Goossens; Sophie Duban-Deweer; Jean Pommery; Jean-Pierre Hénichart; Jean-François Goossens
Spectroscopic study of fluorescent peptides for prenyl transferase assays.
Journal of pharmaceutical and biomedical analysis 2005;37(3):417-22.
2005: Nicolas Wlodarczyk; Pauline Gilleron; Régis Millet; Raymond Houssin; Jean-François Goossens; Amélie Lemoine; Nicole Pommery; Ming X Wei; Jean-Pierre Hénichart
In vitro and in vivo evaluation of two rational-designed nonpeptidic farnesyltransferase inhibitors on HT29 human colon cancer cell lines.
Oncology research 2005;16(3):107-18.
2004: Régis Millet; Juozas Domarkas; Raymond Houssin; Pauline Gilleron; Jean-François Goossens; Philippe CHAVATTE; Cédric Logé; Nicole Pommery; Jean Pommery; Jean-Pierre Hénichart
Potent and selective farnesyl transferase inhibitors.
Journal of medicinal chemistry 2004;47(27):6812-20.
2004: Nicole Pommery; Thierry Taverne; Aurélie Telliez; Laurence Goossens; Caroline Charlier; Jean Pommery; Jean-François Goossens; Raymond Houssin; François Durant; Jean-Pierre Hénichart
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.
Journal of medicinal chemistry 2004;47(25):6195-206.
2004: Catherine Foulon; Cécile Danel; Marie-Pierre Vaccher; Jean-Paul Bonte; Claude Vaccher; Jean-François Goossens
Chiral separation of N-imidazole derivatives, aromatase inhibitors, by cyclodextrin-capillary zone electrophoresis. Mechanism of enantioselective recognition.
Electrophoresis 2004;25(16):2735-44.
2004: Sarah Catoen-Chackal; Michaël Facompré; Raymond Houssin; Nicole Pommery; Jean-François Goossens; Pierre Colson; Christian Bailly; Jean-Pierre Hénichart
DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline derivatives as cytotoxic agents.
Journal of medicinal chemistry 2004;47(14):3665-73.
2004: Catherine Foulon; Cécile Danel; Claude Vaccher; Saïd Yous; Jean-Paul Bonte; Jean-François Goossens
Determination of ionization constants of N-imidazole derivatives, aromatase inhibitors, using capillary electrophoresis and influence of substituents on pKa shifts.
Journal of chromatography. A 2004;1035(1):131-6.
2004: Natacha Malecki; Pascal Carato; Benoît Rigo; Jean-François Goossens; Raymond Houssin; Christian Bailly; Jean-Pierre Hénichart
Synthesis of condensed quinolines and quinazolines as DNA ligands.
Bioorganic & medicinal chemistry 2004;12(3):641-7.
2003: Marie-Hélène David-Cordonnier; William Laine; Alexandra Joubert; Christelle Tardy; Jean-François Goossens; Mostafa Kouach; Gilbert Briand; Huong Doan Thi Mai; Sylvie Michel; François Tillequin; Michel Koch; stephane leonce; Alain Pierre; Christian Bailly
Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1.
European journal of biochemistry / FEBS 2003;270(13):2848-59.
2003: Aurore Perzyna; Raymond Houssin; Jean-François Goossens; Nicole Pommery; Carine Marty; Michaël Facompré; Pierre Colson; Claude Houssier; Christian Bailly; Jean-Pierre Hénichart
Indolizino[1,2-b]quinolines derived from A-D rings of camptothecin: synthesis and DNA interaction.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):101-9.
2003: Sarah Chackal; Michaël Facompré; Raymond Houssin; Jean-François Goossens; Nicole Pommery; Jean-Pierre Hénichart; Christian Bailly
Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines.
Bioorganic & medicinal chemistry letters 2003;13(5):943-6.
2003: Jean-François Goossens; jerome kluza; Hervé Vezin; Mostafa Kouach; Gilbert Briand; Brigitte Baldeyrou; Nicole Wattez; Christian Bailly
Plasma stability of two glycosyl indolocarbazole antitumor agents.
Biochemical pharmacology 2003;65(1):25-34.
2002: Aurore Perzyna; Carine Marty; Michaël Facompré; Jean-François Goossens; Nicole Pommery; Pierre Colson; Claude Houssier; Raymond Houssin; Jean-Pierre Hénichart; Christian Bailly
Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.
Journal of medicinal chemistry 2002;45(26):5809-12.
2002: Bertrand Le Bourdonnec; Christine Cauvin; Emmanuelle Meulon; Saïd Yous; Jean-François Goossens; François Durant; Raymond Houssin; Jean-Pierre Hénichart
Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.
Journal of medicinal chemistry 2002;45(21):4794-8.
2002: Régis Millet; Juozas Domarkas; Benoît Rigo; Laurence Goossens; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives.
Bioorganic & medicinal chemistry 2002;10(9):2905-12.
2002: Catherine Foulon; Jean-François Goossens; Eric Fourmaintraux; Jean-Paul Bonte; Claude Vaccher
Chiral capillary electrophoretic determination of the enantiomeric purity of tetrahydronaphthalenic derivatives, melatoninergic ligands, using highly sulfated beta-cyclodextrins.
Electrophoresis 2002;23(7-8):1121-8.
2002: Raymond Houssin; Jean Pommery; Marie-Catherine Salaün; Sophie Duban-Deweer; Jean-François Goossens; Philippe CHAVATTE; Jean-Pierre Hénichart
Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.
Journal of medicinal chemistry 2002;45(2):533-6.
2001: Régis Millet; Laurence Goossens; K Bertrand-Caumont; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
A flexible approach to the design of new potent substance P receptor ligands.
The Journal of pharmacy and pharmacology 2001;53(7):929-34.
2001: Régis Millet; Laurence Goossens; Jean-François Goossens; Philippe CHAVATTE; K Bertrand-Caumont; Raymond Houssin; Jean-Pierre Hénichart
Conformation of the tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 deduced from two-dimensional 1H-NMR and conformational energy calculations is related to its affinity for NK1-receptor.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(6):323-30.
2001: Jean-François Goossens; E Bouey-Bencteux; Raymond Houssin; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier; William Laine; Brigitte Baldeyrou; Christian Bailly
DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
Biochemistry 2001;40(15):4663-71.
2001: R Dupont; Jean-François Goossens; Nicole Cotelle; L Vrielynck; Hervé Vezin; Jean-Pierre Hénichart; Philippe Cotelle
New bis-catechols 5-lipoxygenase inhibitors.
Bioorganic & medicinal chemistry 2001;9(2):229-35.
2000: Christian Bailly; Jean-François Goossens; William Laine; Fabrice Anizon; Michelle Prudhomme; J Ren; Jonathan B Chaires
Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.
Journal of medicinal chemistry 2000;43(24):4711-20.
2000: Bertrand Le Bourdonnec; E Meulon; Saïd Yous; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
Synthesis and pharmacological evaluation of new pyrazolidine-3, 5-diones as AT(1) angiotensin II receptor antagonists.
Journal of medicinal chemistry 2000;43(14):2685-97.
2000: Jean-François Goossens; Jean-Pierre Hénichart; Laurent Dassonneville; Michaël Facompré; Christian Bailly
Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(2):125-31.
2000: F Dudouit; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier; N Gelus; Christian Bailly
Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-arylcarboxamidopyrrolo-2-carboxyanilides.
Bioorganic & medicinal chemistry letters 2000;10(6):553-7.
2000: Jean-François Goossens; Jean-Pierre Hénichart; Fabrice Anizon; Michelle Prudhomme; C Dugave; J Riou; Christian Bailly
Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.
European journal of pharmacology 2000;389(2-3):141-6.
1999: Pascale Moreau; Fabrice Anizon; Martine Sancelme; Michelle Prudhomme; D Sevère; Jean-François Riou; Jean-François Goossens; Jean-Pierre Hénichart; Christian Bailly; E Labourier; J Tazzi; Doriano Fabbro; T Meyer; AM Aubertin
Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
Journal of medicinal chemistry 1999;42(10):1816-22.