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Ariamala Gopalsamy

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Ariamala Gopalsamy; Mengxiao Shi; Joel Bard; Eric M Bennett; Wei-Guo Zhang; Ker Yu
Identification of pyrimidine derivatives as hSMG-1 inhibitors.
Yike Ni; Jean-Baptiste Telliez; Julie Liu; Michael Luong; Derek Cole; Rajiah Denny; Ariamala Gopalsamy; J Perry Hall; Yonghan Hu; Manus Ipek; Julie Lee; Lih-Ling Lin
Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.
Yonghan Hu; Manus Ipek; Lih-Ling Lin; Julie Liu; Michael Luong; Yike Ni; Jean-Baptiste Telliez; Suvit Thaisrivongs; Xiaolun Wang; David R Anderson; Timothy Chamberlain; Derek Cole; Rajiah Aldrin Denny; J Perry Hall; Ariamala Gopalsamy
Discovery of indazoles as inhibitors of Tpl2 kinase.

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All Publications

2012: Ariamala Gopalsamy; Mengxiao Shi; Joel Bard; Eric M Bennett; Wei-Guo Zhang; Ker Yu
Identification of pyrimidine derivatives as hSMG-1 inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(21):6636-41.
2011: Yike Ni; Jean-Baptiste Telliez; Julie Liu; Michael Luong; Derek Cole; Rajiah Denny; Ariamala Gopalsamy; J Perry Hall; Yonghan Hu; Manus Ipek; Julie Lee; Lih-Ling Lin
Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(19):5952-6.
2011: Yonghan Hu; Manus Ipek; Lih-Ling Lin; Julie Liu; Michael Luong; Yike Ni; Jean-Baptiste Telliez; Suvit Thaisrivongs; Xiaolun Wang; David R Anderson; Timothy Chamberlain; Derek Cole; Rajiah Aldrin Denny; J Perry Hall; Ariamala Gopalsamy
Discovery of indazoles as inhibitors of Tpl2 kinase.
Bioorganic & medicinal chemistry letters 2011;21(16):4758-61.
2010: Matthew G LaPorte; Tandy L Draper; Lori E Miller; Charles W Blackledge; Lara K Leister; Eugene Amparo; Alison R Hussey; Dorothy C Young; Srinivas K Chunduru; Christopher A Benetatos; Gerry Rhodes; Ariamala Gopalsamy; Torsten Herbertz; Christopher J Burns; Stephen M Condon
The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase.
Bioorganic & medicinal chemistry letters 2010;20(9):2968-73.
2010: Ariamala Gopalsamy; Mengxiao Shi; Yongbo Hu; Frederick Lee; Larry Feldberg; Eileen Frommer; Steven Kim; Karen Collins; Donald Wojciechowicz; Robert Mallon
B-Raf kinase inhibitors: hit enrichment through scaffold hopping.
Bioorganic & medicinal chemistry letters 2010;20(8):2431-4.
2009: Ariamala Gopalsamy; Gregory Ciszewski; Mengxiao Shi; Dan Berger; Yongbo Hu; Frederick Lee; Larry Feldberg; Eileen Frommer; Steven Kim; Karen Collins; Donald Wojciechowicz; Robert Mallon
Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(24):6890-2.
2009: Dan M Berger; Nancy Torres; Minu Dutia; Dennis Powell; Greg Ciszewski; Ariamala Gopalsamy; Jeremy I Levin; Kyung-Hee Kim; Weixin Xu; James Wilhelm; YongBo Hu; Karen Collins; Larry Feldberg; Steven Kim; Eileen Frommer; Donald Wojciechowicz; Robert Mallon
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(23):6519-23.
2009: Mengxiao Shi; Barbara Stauffer; Ramesh Bhat; Julia Billiard; Helga Ponce-de-Leon; Laura Seestaller-Wehr; Shoichi Fukayama; Annamarie Mangine; Robert Moran; Girija Krishnamurthy; Peter Bodine; Ariamala Gopalsamy
Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(22):6337-9.
2009: Kaapjoo Park; Ariamala Gopalsamy; Alexis Aplasca; John W Ellingboe; Weixin Xu; Yuhua Zhang; Jeremy I Levin
Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.
Bioorganic & medicinal chemistry 2009;17(11):3857-65.
2009: Peter V N Bodine; Barbara Stauffer; Helga Ponce-de-Leon; Ramesh A Bhat; Annamarie Mangine; Laura M Seestaller-Wehr; Robert A Moran; Julia Billiard; Shoichi Fukayama; Barry S Komm; Keith Pitts; Girija Krishnamurthy; Ariamala Gopalsamy; Mengxiao Shi; Jeffrey C Kern; Thomas J Commons; Richard P Woodworth; Matthew A Wilson; Gregory S Welmaker; Eugene J Trybulski; William J Moore
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
Bone 2009;44(6):1063-8.
2009: Ariamala Gopalsamy; Gregory Ciszewski; Yongbo Hu; Frederick Lee; Larry Feldberg; Eileen Frommer; Steven Kim; Karen Collins; Donald Wojciechowicz; Robert Mallon
Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(10):2735-8.
2008: Brian J Arey; Stephen D Yanofsky; M Claudia Pérez; Christopher P Holmes; Jay Wrobel; Ariamala Gopalsamy; Panayiotis E Stevis; Francisco J López; Richard Winneker
Differing pharmacological activities of thiazolidinone analogs at the FSH receptor.
Biochemical and biophysical research communications 2008;368(3):723-8.
2008: Ariamala Gopalsamy; Mengxiao Shi; Jennifer M Golas; Erik Vogan; Jaison Jacob; Mark Johnson; Frederick Lee; Ramaswamy Nilakantan; Roseann Petersen; Kristine Svenson; Rajiv Chopra; May S Tam; Yingxia Wen; John W Ellingboe; Kim Arndt; Frank Boschelli
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Journal of medicinal chemistry 2008;51(3):373-5.
2007: Ariamala Gopalsamy; Mengxiao Shi; Diane H Boschelli; Robert Williamson; Andrea Olland; Yongbo Hu; Girija Krishnamurthy; Xin Han; Kim Arndt; Bing Guo
Discovery of dibenzo[c,f][2,7]naphthyridines as potent and selective 3-phosphoinositide-dependent kinase-1 inhibitors.
Journal of medicinal chemistry 2007;50(23):5547-9.
2007: Dennis Powell; Ariamala Gopalsamy; Yanong D Wang; Nan Zhang; Miriam Miranda; John P McGinnis; Sridhar K Rabindran
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships.
Bioorganic & medicinal chemistry letters 2007;17(6):1641-5.
2006: Ariamala Gopalsamy; Rajiv Chopra; Kitae Lim; Gregory Ciszewski; Mengxiao Shi; Kevin Joseph Curran; Steven F Sukits; Kristine Svenson; Jonathan Bard; John W Ellingboe; Atul Agarwal; Girija Krishnamurthy; Anita Y M Howe; Mark Orlowski; Boris Feld; John O'Connell; Tarek S Mansour
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.
Journal of medicinal chemistry 2006;49(11):3052-5.
2006: Ariamala Gopalsamy; Hui Yang; John W Ellingboe; John C McKew; Steve Tam; Diane Joseph-McCarthy; Wen Zhang; Marina Shen; James D Clark
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(11):2978-81.
2006: Ariamala Gopalsamy; Mengxiao Shi; Gregory Ciszewski; Kaapjoo Park; John W Ellingboe; Mark Orlowski; Boris Feld; Anita Y M Howe
Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
Bioorganic & medicinal chemistry letters 2006;16(9):2532-4.
2006: Ariamala Gopalsamy; Alexis Aplasca; Gregory Ciszewski; Kaapjoo Park; John W Ellingboe; Mark Orlowski; Boris Feld; Anita Y M Howe
Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.
Bioorganic & medicinal chemistry letters 2006;16(2):457-60.
2005: Lori Krim Gavrin; Neal Green; Yonghan Hu; Kristin Janz; Neelu Kaila; Huan-Qiu Li; Steve Y Tam; Jennifer R Thomason; Ariamala Gopalsamy; Gregory Ciszewski; John W Cuozzo; J Perry Hall; Sang Hsu; Jean-Baptiste Telliez; Lih-Ling Lin
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2005;15(23):5288-92.
2005: Ariamala Gopalsamy; Hui Yang; John W Ellingboe; Hwei-Ru Tsou; Nan Zhang; Erick Honores; Dennis Powell; Miriam Miranda; John P McGinnis; Sridhar K Rabindran
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region.
Bioorganic & medicinal chemistry letters 2005;15(6):1591-4.
2004: Ariamala Gopalsamy; Kitae Lim; Gregory Ciszewski; Kaapjoo Park; John W Ellingboe; Jonathan Bloom; Shabana Insaf; Janis Upeslacis; Tarek S Mansour; Girija Krishnamurthy; Murthy Damarla; Yelena Pyatski; Douglas Ho; Anita Y M Howe; Mark Orlowski; Boris Feld; John O'Connell
Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.
Journal of medicinal chemistry 2004;47(26):6603-8.
2004: Anita Y M Howe; Jonathan Bloom; Carl J Baldick; Christopher A Benetatos; Huiming Cheng; Joel S Christensen; Srinivas K Chunduru; Glen A Coburn; Boris Feld; Ariamala Gopalsamy; William P Gorczyca; Steve Herrmann; Stephen V Johann; Xiaoqun Jiang; Michelle L Kimberland; Girija Krisnamurthy; Matthew Olson; Mark Orlowski; Steve Swanberg; Ian Thompson; Megan Thorn; Alfred Del Vecchio; Dorothy C Young; Marja van Zeijl; John W Ellingboe; Janis Upeslacis; Marc S Collett; Tarek S Mansour; John F O'Connell
Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase.
Antimicrobial agents and chemotherapy 2004;48(12):4813-21.
2004: Ariamala Gopalsamy; Kitae Lim; John W Ellingboe; Girija Krishnamurthy; Mark Orlowski; Boris Feld; Marja van Zeijl; Anita Y M Howe
Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.
Bioorganic & medicinal chemistry letters 2004;14(16):4221-4.
2004: Ariamala Gopalsamy; Scott L Kincaid; John W Ellingboe; Thomas M Groeling; Thomas M Antrilli; Girija Krishnamurthy; Ann Aulabaugh; Gregory S Friedrichs; David L Crandall
Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1.
Bioorganic & medicinal chemistry letters 2004;14(13):3477-80.
2004: Ariamala Gopalsamy; Kitae Lim; John W Ellingboe; Boris Mitsner; Antonia Nikitenko; Janis Upeslacis; Tarek S Mansour; Matthew W Olson; Geraldine A Bebernitz; Diane Grinberg; Boris Feld; Franklin J Moy; John O'Connell
Design and syntheses of 1,6-naphthalene derivatives as selective HCMV protease inhibitors.
Journal of medicinal chemistry 2004;47(8):1893-9.
2003: Ariamala Gopalsamy; Mengxiao Shi
Novel synthetic approach to 6,7-dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones.
Organic letters 2003;5(21):3907-9.
2000: Ariamala Gopalsamy; Hui Yang; John W Ellingboe; K L Kees; J Yoon; R Murrills
Parallel solid-phase synthesis of vitronectin receptor (alphavbeta3) inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(15):1715-8.