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Husam Abu-Soud

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Faten Shaeib; Jashoman Banerjee; Michael P Diamond; Dhiman Maitra; Husam M Abu-Soud
Impact of hydrogen peroxide-driven Fenton reaction on mouse oocyte quality.
Dhiman Maitra; Ghassan M Saed; Ibrahim Abdulhamid; Michael Diamond; Husam M Abu-Soud
Melatonin attenuates hypochlorous acid-mediated heme destruction, free iron release, and protein aggregation in hemoglobin.
Jashoman Banerjee; Michael Diamond; Dhiman Maitra; Husam M Abu-Soud
Melatonin prevents hypochlorous acid-induced alterations in microtubule and chromosomal structure in metaphase-II mouse oocytes.

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2013: Faten Shaeib; Jashoman Banerjee; Michael P Diamond; Dhiman Maitra; Husam M Abu-Soud
Impact of hydrogen peroxide-driven Fenton reaction on mouse oocyte quality.
Free radical biology & medicine 2013;58():154-9.
2012: Dhiman Maitra; Ghassan M Saed; Ibrahim Abdulhamid; Michael Diamond; Husam M Abu-Soud
Melatonin attenuates hypochlorous acid-mediated heme destruction, free iron release, and protein aggregation in hemoglobin.
Journal of pineal research 2012;53(2):198-205.
2012: Jashoman Banerjee; Michael Diamond; Dhiman Maitra; Husam M Abu-Soud
Melatonin prevents hypochlorous acid-induced alterations in microtubule and chromosomal structure in metaphase-II mouse oocytes.
Journal of pineal research 2012;53(2):122-8.
2012: Husam M Abu-Soud; Peter R Andreana; Jashoman Banerjee; Jaeman Byun; Michael Diamond; Dhiman Maitra; Ghassan M Saed; Carlos Souza; Subramaniam Pennathur
The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogen chloride.
Free radical biology & medicine 2012;52(3):616-25.
2012: Jashoman Banerjee; Michael Diamond; Dhiman Maitra; Rakesh Sharma; Ashok Agarwal; Husam M Abu-Soud
IL-6 and mouse oocyte spindle.
PloS one 2012;7(4):e35535.
2011: Ghassan M Saed; Husam M Abu-Soud; Nicole Fletcher; Zhong L Jiang; Michael Diamond
Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress.
Reproductive sciences (Thousand Oaks, Calif.) 2011;18(12):1253-61.
2011: Zhongliang Jiang; Adnan R Munkarah; Husam M Abu-Soud; Rouba Ali-Fehmi; Michael Diamond; Nicole Fletcher; Ghassan M Saed
Modulation of redox signaling promotes apoptosis in epithelial ovarian cancer cells.
Gynecologic oncology 2011;122(2):418-23.
2011: Dhiman Maitra; Subramaniam Pennathur; Ghassan M Saed; Ibrahim Abdulhamid; Peter R Andreana; Jaeman Byun; Michael Diamond; Husam M Abu-Soud
Reaction of hemoglobin with HOCl: mechanism of heme destruction and free iron release.
Free radical biology & medicine 2011;51(2):374-86.
2011: Dhiman Maitra; Subramaniam Pennathur; Ghassan M Saed; Ibrahim Abdulhamid; Peter R Andreana; Jaeman Byun; Michael Diamond; Husam M Abu-Soud
Mechanism of hypochlorous acid-mediated heme destruction and free iron release.
Free radical biology & medicine 2011;51(2):364-73.
2011: Dhiman Maitra; Jashoman Banerjee; Faten Shaeib; Carlos Souza; Husam M Abu-Soud
Melatonin can mediate its vascular protective effect by modulating free iron level by inhibiting hypochlorous acid-mediated hemoprotein heme destruction.
Hypertension 2011;57(5):e22; author reply e23.
2011: Nicole Fletcher; Zhongliang Jiang; Nancy K Levin; Husam M Abu-Soud; Rouba Ali-Fehmi; Jimmy Belotte; Michael Diamond; Michael A Tainsky; Ghassan M Saed
Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancer.
Cancer biomarkers : section A of Disease markers 2011;10(6):267-75.
2011: Carlos Souza; Michael Diamond; Dhiman Maitra; Arlindo A Moura; Subramaniam Pennathur; Ghassan M Saed; Husam M Abu-Soud
Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases.
PloS one 2011;6(11):e27641.
2010: Subramaniam Pennathur; Dhiman Maitra; Jaeman Byun; Inga Sliskovic; Ibrahim Abdulhamid; Ghassan M Saed; Michael Diamond; Husam M Abu-Soud
Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid.
Free radical biology & medicine 2010;49(2):205-13.
2010: Ghassan M Saed; Zhong L Jiang; Nicole Fletcher; Ali Al Arab; Michael Diamond; Husam M Abu-Soud
Exposure to polychlorinated biphenyls enhances lipid peroxidation in human normal peritoneal and adhesion fibroblasts: a potential role for myeloperoxidase.
Free radical biology & medicine 2010;48(6):845-50.
2010: Ghassan M Saed; Rouba Ali-Fehmi; Zhong L Jiang; Nicole Fletcher; Michael Diamond; Husam M Abu-Soud; Adnan R Munkarah
Myeloperoxidase serves as a redox switch that regulates apoptosis in epithelial ovarian cancer.
Gynecologic oncology 2010;116(2):276-81.
2009: Inga Sliskovic; Ibrahim Abdulhamid; Manju Sharma; Husam M Abu-Soud
Analysis of the mechanism by which tryptophan analogs inhibit human myeloperoxidase.
Free radical biology & medicine 2009;47(7):1005-13.
2009: Semira Galijasevic; Dhiman Maitra; Tun Lu; Inga Sliskovic; Ibrahim Abdulhamid; Husam M Abu-Soud
Myeloperoxidase interaction with peroxynitrite: chloride deficiency and heme depletion.
Free radical biology & medicine 2009;47(4):431-9.
2009: Ghassan M Saed; Zhongliang Jiang; Michael Diamond; Husam M Abu-Soud
The role of myeloperoxidase in the pathogenesis of postoperative adhesions.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2009;17(4):531-9.
2009: Zhong L Jiang; Nicole Fletcher; Michael Diamond; Husam M Abu-Soud; Ghassan M Saed
S-nitrosylation of caspase-3 is the mechanism by which adhesion fibroblasts manifest lower apoptosis.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2009;17(2):224-9.
2009: Zhong L Jiang; Nicole Fletcher; Michael Diamond; Husam M Abu-Soud; Ghassan M Saed
Hypoxia regulates iNOS expression in human normal peritoneal and adhesion fibroblasts through nuclear factor kappa B activation mechanism.
Fertility and sterility 2009;91(2):616-21.
2008: Zhong L Jiang; Xuping Zhu; Michael Diamond; Husam M Abu-Soud; Ghassan M Saed
Nitric oxide synthase isoforms expression in fibroblasts isolated from human normal peritoneum and adhesion tissues.
Fertility and sterility 2008;90(3):769-74.
2008: Nicole Fletcher; Zhong L Jiang; Michael Diamond; Husam M Abu-Soud; Ghassan M Saed
Hypoxia-generated superoxide induces the development of the adhesion phenotype.
Free radical biology & medicine 2008;45(4):530-6.
2008: Pravin T Goud; Anuradha P Goud; Michael Diamond; Bernard Gonik; Husam M Abu-Soud
Nitric oxide extends the oocyte temporal window for optimal fertilization.
Free radical biology & medicine 2008;45(4):453-9.
2008: T Lu; Semira Galijasevic; Ibrahim Abdulhamid; Husam M Abu-Soud
Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase.
British journal of pharmacology 2008;154(6):1308-17.
2008: Semira Galijasevic; Ibrahim Abdulhamid; Husam M Abu-Soud
Potential role of tryptophan and chloride in the inhibition of human myeloperoxidase.
Free radical biology & medicine 2008;44(8):1570-7.
2008: Anuradha P Goud; Pravin T Goud; Michael Diamond; Bernard Gonik; Husam M Abu-Soud
Reactive oxygen species and oocyte aging: role of superoxide, hydrogen peroxide, and hypochlorous acid.
Free radical biology & medicine 2008;44(7):1295-304.
2008: Semira Galijasevic; Ibrahim Abdulhamid; Husam M Abu-Soud
Melatonin is a potent inhibitor for myeloperoxidase.
Biochemistry 2008;47(8):2668-77.
2007: Semira Galijasevic; Gheorghe Proteasa; Ibrahim Abdulhamid; Husam M Abu-Soud
The potential role of nitric oxide in substrate switching in eosinophil peroxidase.
Biochemistry 2007;46(2):406-15.
2007: Gheorghe Proteasa; Yahya R Tahboub; Semira Galijasevic; Frank M Raushel; Husam M Abu-Soud
Kinetic evidence supports the existence of two halide binding sites that have a distinct impact on the heme iron microenvironment in myeloperoxidase.
Biochemistry 2007;46(2):398-405.
2006: Anuradha P Goud; Pravin T Goud; Michael Diamond; Bernard Gonik; Husam M Abu-Soud
Activation of the cGMP signaling pathway is essential in delaying oocyte aging in diabetes mellitus.
Biochemistry 2006;45(38):11366-78.
2006: Ghassan M Saed; M Zhao; Michael Diamond; Husam M Abu-Soud
Regulation of inducible nitric oxide synthase in post-operative adhesions.
Human reproduction (Oxford, England) 2006;21(6):1605-11.
2006: Semira Galijasevic; Ghassan M Saed; Stanley L Hazen; Husam M Abu-Soud
Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.
Biochemistry 2006;45(4):1255-62.
2005: Anuradha P Goud; Pravin T Goud; Michael Diamond; Husam M Abu-Soud
Nitric oxide delays oocyte aging.
Biochemistry 2005;44(34):11361-8.
2005: Yahya R Tahboub; Semira Galijasevic; Michael Diamond; Husam M Abu-Soud
Thiocyanate modulates the catalytic activity of mammalian peroxidases.
The Journal of biological chemistry 2005;280(28):26129-36.
2005: Ghassan M Saed; Semira Galijasevic; Michael Diamond; Husam M Abu-Soud
Measurement of oxygen and nitric oxide levels in vitro and in vivo: relationship to postoperative adhesions.
Fertility and sterility 2005;84(1):235-8.
2005: Ghassan M Saed; Adnan R Munkarah; Husam M Abu-Soud; Michael Diamond
Hypoxia upregulates cyclooxygenase-2 and prostaglandin E(2) levels in human peritoneal fibroblasts.
Fertility and sterility 2005;83 Suppl 1():1216-9.
2004: Ghassan M Saed; Husam M Abu-Soud; Michael Diamond
Role of nitric oxide in apoptosis of human peritoneal and adhesion fibroblasts after hypoxia.
Fertility and sterility 2004;82 Suppl 3():1198-205.
2004: Semira Galijasevic; Ghassan M Saed; Michael Diamond; Husam M Abu-Soud
High dissociation rate constant of ferrous-dioxy complex linked to the catalase-like activity in lactoperoxidase.
The Journal of biological chemistry 2004;279(38):39465-70.
2004: Husam M Abu-Soud; Frank M Raushel; Stanley L Hazen
A novel multistep mechanism for oxygen binding to ferrous hemoproteins: rapid kinetic analysis of ferrous-dioxy myeloperoxidase (compound III) formation.
Biochemistry 2004;43(36):11589-95.
2003: Semira Galijasevic; Ghassan M Saed; Michael Diamond; Husam M Abu-Soud
Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14766-71.
2002: Marie-Luise Brennan; Weijia Wu; Xiaoming Fu; Zhongzhu Shen; Wei Song; Heather Frost; Caryn Vadseth; Laura Narine; Elizabeth Lenkiewicz; Michael T Borchers; Aldons J Lusis; James J Lee; Nancy A Lee; Husam M Abu-Soud; Harry Ischiropoulos; Stanley L Hazen
A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species.
The Journal of biological chemistry 2002;277(20):17415-27.
2001: Husam M Abu-Soud; M Y Khassawneh; Ju-Tae Sohn; P Murray; M A Haxhiu; Stanley L Hazen
Peroxidases inhibit nitric oxide (NO) dependent bronchodilation: development of a model describing NO-peroxidase interactions.
Biochemistry 2001;40(39):11866-75.
2001: Husam M Abu-Soud; Stanley L Hazen
Interrogation of heme pocket environment of mammalian peroxidases with diatomic ligands.
Biochemistry 2001;40(36):10747-55.
2001: Husam M Abu-Soud; K Ichimori; H Nakazawa; Dennis J Stuehr
Regulation of inducible nitric oxide synthase by self-generated NO.
Biochemistry 2001;40(23):6876-81.
2001: raed dweik; Suzy A A Comhair; Benjamin Gaston; Frederik B J M Thunnissen; Carol Farver; Mary Jane Thomassen; mani kavuru; Jeffrey P Hammel; Husam M Abu-Soud; Serpil C Erzurum
NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2622-7.
2000: Husam M Abu-Soud; Stanley L Hazen
Nitric oxide is a physiological substrate for mammalian peroxidases.
The Journal of biological chemistry 2000;275(48):37524-32.
2000: Eugene A Podrez; Husam M Abu-Soud; Stanley L Hazen
Myeloperoxidase-generated oxidants and atherosclerosis.
Free radical biology & medicine 2000;28(12):1717-25.
2000: Husam M Abu-Soud; K Ichimori; A Presta; Dennis J Stuehr
Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase.
The Journal of biological chemistry 2000;275(23):17349-57.
2000: Husam M Abu-Soud; Stanley L Hazen
Nitric oxide modulates the catalytic activity of myeloperoxidase.
The Journal of biological chemistry 2000;275(8):5425-30.
1999: Stanley L Hazen; R Zhang; Z Shen; Weijia Wu; Eugene A Podrez; J C MacPherson; Dave Schmitt; SN Mitra; C Mukhopadhyay; Yishi Chen; P A Cohen; Henry F Hoff; Husam M Abu-Soud
Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivo.
Circulation research 1999;85(10):950-8.
1999: Husam M Abu-Soud; J Wang; Denis L Rousseau; Dennis J Stuehr
Stopped-flow analysis of substrate binding to neuronal nitric oxide synthase.
Biochemistry 1999;38(38):12446-51.
1999: Subrata Adak; Sanjay Ghosh; Husam M Abu-Soud; Dennis J Stuehr
Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme.
The Journal of biological chemistry 1999;274(32):22313-20.
1999: L Huang; Husam M Abu-Soud; Russ Hille; Dennis J Stuehr
Nitric oxide-generated P420 nitric oxide synthase: characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion.
Biochemistry 1999;38(6):1912-20.
1998: Husam M Abu-Soud; Chuanyue Wu; DK Ghosh; Dennis J Stuehr
Stopped-flow analysis of CO and NO binding to inducible nitric oxide synthase.
Biochemistry 1998;37(11):3777-86.
1998: Ratan Gachhui; Husam M Abu-Soud; D K Ghosha; A Presta; Michael A Blazing; Bernd Mayer; Samuel E George; Dennis J Stuehr
Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras.
The Journal of biological chemistry 1998;273(10):5451-4.
1998: W A Francisco; Husam M Abu-Soud; A J DelMonte; Daniel A Singleton; Thomas O Baldwin; Frank M Raushel
Deuterium kinetic isotope effects and the mechanism of the bacterial luciferase reaction.
Biochemistry 1998;37(8):2596-606.
1998: raed dweik; Daniel Laskowski; Husam M Abu-Soud; F Kaneko; R Hutte; D J Stuehr; Serpil C Erzurum
Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism.
The Journal of clinical investigation 1998;101(3):660-6.
1998: A Presta; U Siddhanta; Chuanyue Wu; N Sennequier; L Huang; Husam M Abu-Soud; Serpil C Erzurum; Dennis J Stuehr
Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase.
Biochemistry 1998;37(1):298-310.
1997: Husam M Abu-Soud; A Presta; Bernd Mayer; Dennis J Stuehr
Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline.
Biochemistry 1997;36(36):10811-6.
1997: Husam M Abu-Soud; Ratan Gachhui; F M Raushel; Dennis J Stuehr
The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability.
The Journal of biological chemistry 1997;272(28):17349-53.
1996: Husam M Abu-Soud; Denis L Rousseau; Dennis J Stuehr
Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension.
The Journal of biological chemistry 1996;271(51):32515-8.
1996: Ratan Gachhui; A Presta; D F Bentley; Husam M Abu-Soud; R McArthur; Gary W Brudvig; DK Ghosh; Dennis J Stuehr
Characterization of the reductase domain of rat neuronal nitric oxide synthase generated in the methylotrophic yeast Pichia pastoris. Calmodulin response is complete within the reductase domain itself.
The Journal of biological chemistry 1996;271(34):20594-602.
1996: C Wu; J Zhang; Husam M Abu-Soud; D K Ghosh; Dennis J Stuehr
High-level expression of mouse inducible nitric oxide synthase in Escherichia coli requires coexpression with calmodulin.
Biochemical and biophysical research communications 1996;222(2):439-44.
1996: U Siddhanta; Chuanyue Wu; Husam M Abu-Soud; J Zhang; DK Ghosh; Dennis J Stuehr
Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains.
The Journal of biological chemistry 1996;271(13):7309-12.
1996: C Galli; R MacArthur; Husam M Abu-Soud; P Clark; D J Steuhr; Gary W Brudvig
EPR spectroscopic characterization of neuronal NO synthase.
Biochemistry 1996;35(8):2804-10.
1996: DK Ghosh; Husam M Abu-Soud; Dennis J Stuehr
Domains of macrophage N(O) synthase have divergent roles in forming and stabilizing the active dimeric enzyme.
Biochemistry 1996;35(5):1444-9.
1996: W A Francisco; Husam M Abu-Soud; R Topgi; Thomas O Baldwin; Frank M Raushel
Interaction of bacterial luciferase with 8-substituted flavin mononucleotide derivatives.
The Journal of biological chemistry 1996;271(1):104-10.
1995: Husam M Abu-Soud; J Wang; Denis L Rousseau; J M Fukuto; Louis J Ignarro; Dennis J Stuehr
Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis.
The Journal of biological chemistry 1995;270(39):22997-3006.
1995: DK Ghosh; Husam M Abu-Soud; Dennis J Stuehr
Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase.
Biochemistry 1995;34(36):11316-20.
1995: Husam M Abu-Soud; M Loftus; Dennis J Stuehr
Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function.
Biochemistry 1995;34(35):11167-75.
1995: Dennis J Stuehr; Husam M Abu-Soud; Denis L Rousseau; P L Feldman; J Wang
Control of electron transfer in neuronal nitric oxide synthase by calmodulin, substrate, substrate analogs, and nitric oxide.
Advances in pharmacology (San Diego, Calif.) 1995;34():207-13.
1994: Husam M Abu-Soud; P L Feldman; P Clark; Dennis J Stuehr
Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.
The Journal of biological chemistry 1994;269(51):32318-26.
1994: Husam M Abu-Soud; L L Yoho; Dennis J Stuehr
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.
The Journal of biological chemistry 1994;269(51):32047-50.
1994: J Wang; Denis L Rousseau; Husam M Abu-Soud; D J Stuehr
Heme coordination of NO in NO synthase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10512-6.
1993: W A Francisco; Husam M Abu-Soud; Thomas O Baldwin; Frank M Raushel
Interaction of bacterial luciferase with aldehyde substrates and inhibitors.
The Journal of biological chemistry 1993;268(33):24734-41.
1993: Husam M Abu-Soud; Dennis J Stuehr
Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10769-72.
1993: Husam M Abu-Soud; A C Clark; W A Francisco; Thomas O Baldwin; Frank M Raushel
Kinetic destabilization of the hydroperoxy flavin intermediate by site-directed modification of the reactive thiol in bacterial luciferase.
The Journal of biological chemistry 1993;268(11):7699-706.
1993: E J Rodríguez; CM Debouck; I C Deckman; Husam M Abu-Soud; F M Raushel; Thomas D Meek
Inhibitor binding to the Phe53Trp mutant of HIV-1 protease promotes conformational changes detectable by spectrofluorometry.
Biochemistry 1993;32(14):3557-63.
1993: R Rajapaksa; Husam M Abu-Soud; F M Raushel; Ben G Harris; Paul F Cook
Pre-steady-state kinetics reveal a slow isomerization of the enzyme-NAD complex in the NAD-malic enzyme reaction.
Biochemistry 1993;32(8):1928-34.
1992: Husam M Abu-Soud; LS Mullins; Thomas O Baldwin; Frank M Raushel
Stopped-flow kinetic analysis of the bacterial luciferase reaction.
Biochemistry 1992;31(15):3807-13.