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Darci Gorgone

Research Profile

Living Beings

Chemicals & Drugs

Disorders

Simian Acquired Immunodeficiency Syndrome

Anatomy

Physiology

Immunologic Memory

Procedures

Vaccination

Co-author Network

Publications

TOP 3
Norman L Letvin; John R Mascola; Yue Sun; Darci A Gorgone; Adam P Buzby; Ling Xu; Zhi-Yong Yang; Bimal K Chakrabarti; SRINIVAS RAO; Joern schmitz; David C Montefiori; Brianne R Barker; Fred L Bookstein; Gary Nabel
Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
Diane M Roberts; Anjali Nanda; Menzo J E Havenga; peter abbink; Diana M Lynch; Bonnie A Ewald; Jinyan Liu; Anna R Thorner; Patricia E Swanson; Darci A Gorgone; Michelle A Lifton; Angelique A C Lemckert; Lennart Holterman; Bing Chen; Athmanundh Dilraj; Angela Carville; Keith G Mansfield; Jaap Goudsmit; Dan H Barouch
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity.
Ramu A Subbramanian; William A Charini; Marcelo J Kuroda; Michael S Seaman; Heng Chhay; Michelle A Lifton; Darci A Gorgone; Joern schmitz; Angela Carville; Norman L Letvin
Expansion after epitope peptide exposure in vitro predicts cytotoxic T lymphocyte epitope dominance hierarchy in lymphocytes of vaccinated mamu-a*01+ rhesus monkeys.

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All Publications

2006: Norman L Letvin; John R Mascola; Yue Sun; Darci A Gorgone; Adam P Buzby; Ling Xu; Zhi-Yong Yang; Bimal K Chakrabarti; SRINIVAS RAO; Joern schmitz; David C Montefiori; Brianne R Barker; Fred L Bookstein; Gary Nabel
Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
Science (New York, N.Y.) 2006;312(5779):1530-3.
2006: Diane M Roberts; Anjali Nanda; Menzo J E Havenga; peter abbink; Diana M Lynch; Bonnie A Ewald; Jinyan Liu; Anna R Thorner; Patricia E Swanson; Darci A Gorgone; Michelle A Lifton; Angelique A C Lemckert; Lennart Holterman; Bing Chen; Athmanundh Dilraj; Angela Carville; Keith G Mansfield; Jaap Goudsmit; Dan H Barouch
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity.
Nature 2006;441(7090):239-43.
2006: Ramu A Subbramanian; William A Charini; Marcelo J Kuroda; Michael S Seaman; Heng Chhay; Michelle A Lifton; Darci A Gorgone; Joern schmitz; Angela Carville; Norman L Letvin
Expansion after epitope peptide exposure in vitro predicts cytotoxic T lymphocyte epitope dominance hierarchy in lymphocytes of vaccinated mamu-a*01+ rhesus monkeys.
AIDS research and human retroviruses 2006;22(5):445-52.
2006: Paula M Acierno; Joern schmitz; Darci A Gorgone; Yue Sun; Sampa Santra; Michael S Seaman; Michael H Newberg; John R Mascola; Gary Nabel; Dennis Panicali; Norman L Letvin
Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5338-45.
2006: Mark J Cayabyab; Avi-Hai Hovav; Tsungda Hsu; Georgia R Krivulka; Michelle A Lifton; Darci A Gorgone; Glenn Fennelly; Barton F Haynes; William R. Jacobs Jr.; Norman L Letvin
Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env.
Journal of virology 2006;80(4):1645-52.
2006: Michael H Newberg; Kimberly J McEvers; Darci A Gorgone; Michelle A Lifton; Susanne H C Baumeister; Ronald S Veazey; Joern schmitz; Norman L Letvin
Immunodomination in the evolution of dominant epitope-specific CD8+ T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):319-28.
2005: Shawn S Jackson; Joern schmitz; Marcelo J Kuroda; Paul F McKay; Shawn M Sumida; Kristi L Martin; Faye Yu; Michelle A Lifton; Darci A Gorgone; Norman L Letvin
Evaluation of CD62L expression as a marker for vaccine-elicited memory cytotoxic T lymphocytes.
Immunology 2005;116(4):443-53.
2005: Anjali Nanda; Diana M Lynch; Jaap Goudsmit; Angelique A C Lemckert; Bonnie A Ewald; Shawn M Sumida; Diana M Truitt; peter abbink; Michael G Kishko; Darci A Gorgone; Michelle A Lifton; Ling Shen; Angela Carville; Keith G Mansfield; Menzo J E Havenga; Dan H Barouch
Immunogenicity of recombinant fiber-chimeric adenovirus serotype 35 vector-based vaccines in mice and rhesus monkeys.
Journal of virology 2005;79(22):14161-8.
2005: Angelique A C Lemckert; Shawn M Sumida; Lennart Holterman; Ronald Vogels; Diana M Truitt; Diana M Lynch; Anjali Nanda; Bonnie A Ewald; Darci A Gorgone; Michelle A Lifton; Jaap Goudsmit; Menzo J E Havenga; Dan H Barouch
Immunogenicity of heterologous prime-boost regimens involving recombinant adenovirus serotype 11 (Ad11) and Ad35 vaccine vectors in the presence of anti-ad5 immunity.
Journal of virology 2005;79(15):9694-701.
2005: Shawn M Sumida; Diana M Truitt; Angelique A C Lemckert; Ronald Vogels; Jerome H H V Custers; Marylyn M Addo; Shahin Lockman; Trevor Peter; Fred W Peyerl; Michael G Kishko; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Myron Essex; Bruce D Walker; Jaap Goudsmit; Menzo J E Havenga; Dan H Barouch
Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7179-85.
2005: Sampa Santra; Michael S Seaman; Ling Xu; Dan H Barouch; Carol I Lord; Michelle A Lifton; Darci A Gorgone; Kristin Beaudry; Krisha Svehla; Brent Welcher; Bimal K Chakrabarti; Yue Huang; Zhi-Yong Yang; John R Mascola; Gary Nabel; Norman L Letvin
Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates.
Journal of virology 2005;79(10):6516-22.
2005: Yue Sun; Joern schmitz; Paula M Acierno; Sampa Santra; Ramu A Subbramanian; Dan H Barouch; Darci A Gorgone; Michelle A Lifton; Kristin Beaudry; Kelledy Manson; Valerie Philippon; Ling Xu; Holden T Maecker; John R Mascola; Dennis Panicali; Gary Nabel; Norman L Letvin
Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4753-60.
2005: Dan H Barouch; Jennifer Powers; Diana M Truitt; Michael G Kishko; Janelle C Arthur; Fred W Peyerl; Marcelo J Kuroda; Darci A Gorgone; Michelle A Lifton; Carol I Lord; Vanessa M Hirsch; David C Montefiori; Angela Carville; Keith G Mansfield; Kevin Kunstman; Steven Wolinsky; Norman L Letvin
Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants.
Nature immunology 2005;6(3):247-52.
2004: Shawn M Sumida; Paul F McKay; Diana M Truitt; Michael G Kishko; Janelle C Arthur; Michael S Seaman; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Norman L Letvin; Dan H Barouch
Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines.
The Journal of clinical investigation 2004;114(9):1334-42.
2004: Ramu A Subbramanian; Chikaya Moriya; Kristi L Martin; Fred W Peyerl; Atsuhiko Hasegawa; Akira Naoi; Heng Chhay; Patrick Autissier; Darci A Gorgone; Michelle A Lifton; Kristine Kuus-Reichel; Joern schmitz; Norman L Letvin; Marcelo J Kuroda
Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity.
Nature biotechnology 2004;22(11):1429-34.
2004: Sallie R Permar; Sherry A Klumpp; Keith G Mansfield; Angela Carville; Darci A Gorgone; Michelle A Lifton; Joern schmitz; Keith A Reimann; Fernando P Polack; Diane E Griffin; Norman L Letvin
Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys.
The Journal of infectious diseases 2004;190(5):998-1005.
2004: Sampa Santra; Dan H Barouch; Birgit Korioth-Schmitz; Carol I Lord; Georgia R Krivulka; Faye Yu; Margaret H Beddall; Darci A Gorgone; Michelle A Lifton; Ayako Miura; Valerie Philippon; Kelledy Manson; Phillip D Markham; John Parrish; Marcelo J Kuroda; Joern schmitz; Rebecca Gelman; John W Shiver; David C Montefiori; Dennis Panicali; Norman L Letvin
Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):11088-93.
2004: Dan H Barouch; Maria G Pau; Jerome H H V Custers; Wouter Koudstaal; Stefan Kostense; Menzo J E Havenga; Diana M Truitt; Shawn M Sumida; Michael G Kishko; Janelle C Arthur; Birgit Korioth-Schmitz; Michael H Newberg; Darci A Gorgone; Michelle A Lifton; Dennis Panicali; Gary Nabel; Norman L Letvin; Jaap Goudsmit
Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6290-7.
2004: Paul F McKay; Dan H Barouch; Sampa Santra; Shawn M Sumida; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Norman L Letvin
Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte responses.
European journal of immunology 2004;34(4):1011-20.
2004: Shawn M Sumida; Diana M Truitt; Michael G Kishko; Janelle C Arthur; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Wouter Koudstaal; Maria G Pau; Stefan Kostense; Menzo J E Havenga; Jaap Goudsmit; Norman L Letvin; Dan H Barouch
Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors.
Journal of virology 2004;78(6):2666-73.
2004: Michael S Seaman; Fred W Peyerl; Shawn S Jackson; Michelle A Lifton; Darci A Gorgone; Joern schmitz; Norman L Letvin
Subsets of memory cytotoxic T lymphocytes elicited by vaccination influence the efficiency of secondary expansion in vivo.
Journal of virology 2004;78(1):206-15.
2003: Renaud A Du Pasquier; Marcelo J Kuroda; Joern schmitz; Yue Zheng; Kristi Martin; Fred W Peyerl; Michelle A Lifton; Darci A Gorgone; Patrick Autissier; Norman L Letvin; Igor J Koralnik
Low frequency of cytotoxic T lymphocytes against the novel HLA-A*0201-restricted JC virus epitope VP1(p36) in patients with proven or possible progressive multifocal leukoencephalopathy.
Journal of virology 2003;77(22):11918-26.
2003: Ramu A Subbramanian; Marcelo J Kuroda; William A Charini; Dan H Barouch; Cristina Costantino; Sampa Santra; Joern schmitz; Kristi L Martin; Michelle A Lifton; Darci A Gorgone; John W Shiver; Norman L Letvin
Magnitude and diversity of cytotoxic-T-lymphocyte responses elicited by multiepitope DNA vaccination in rhesus monkeys.
Journal of virology 2003;77(18):10113-8.
2003: Dan H Barouch; Paul F McKay; Shawn M Sumida; Sampa Santra; Shawn S Jackson; Darci A Gorgone; Michelle A Lifton; Bimal K Chakrabarti; Ling Xu; Gary Nabel; Norman L Letvin
Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines.
Journal of virology 2003;77(16):8729-35.
2003: Dan H Barouch; Jennifer Kunstman; Jennifer Glowczwskie; Kevin Kunstman; Michael A Egan; Fred W Peyerl; Sampa Santra; Marcelo J Kuroda; Joern schmitz; Kristin Beaudry; Georgia R Krivulka; Michelle A Lifton; Darci A Gorgone; Steven Wolinsky; Norman L Letvin
Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys.
Journal of virology 2003;77(13):7367-75.
2003: Paul F McKay; Dan H Barouch; Joern schmitz; Ronald S Veazey; Darci A Gorgone; Michelle A Lifton; Kenneth C Williams; Norman L Letvin
Global dysfunction of CD4 T-lymphocyte cytokine expression in simian-human immunodeficiency virus/SIV-infected monkeys is prevented by vaccination.
Journal of virology 2003;77(8):4695-702.
2003: Sallie R Permar; Sherry A Klumpp; Keith G Mansfield; Woong-Ki Kim; Darci A Gorgone; Michelle A Lifton; Kenneth C Williams; Joern schmitz; Keith A Reimann; Michael K Axthelm; Fernando P Polack; Diane E Griffin; Norman L Letvin
Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys.
Journal of virology 2003;77(7):4396-400.
2002: Jamal Baig; Daniel B Levy; Paul F McKay; Joern schmitz; Sampa Santra; Ramu A Subbramanian; Marcelo J Kuroda; Michelle A Lifton; Darci A Gorgone; Linda S Wyatt; Bernard Moss; Yue Huang; Bimal K Chakrabarti; Ling Xu; Wing-Pui Kong; Zhi-Yong Yang; John R Mascola; Gary Nabel; Angela Carville; Andrew Lackner; Ronald S Veazey; Norman L Letvin
Elicitation of simian immunodeficiency virus-specific cytotoxic T lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination.
Journal of virology 2002;76(22):11484-90.
2002: Michael H Newberg; Marcelo J Kuroda; William A Charini; Ayako Miura; Carol I Lord; Joern schmitz; Darci A Gorgone; Michelle A Lifton; Kristine Kuus-Reichel; Norman L Letvin
A simian immunodeficiency virus nef peptide is a dominant cytotoxic T lymphocyte epitope in Indian-origin rhesus monkeys expressing the common MHC class I allele mamu-A*02.
Virology 2002;301(2):365-73.
2002: Dan H Barouch; Jennifer Kunstman; Marcelo J Kuroda; Joern schmitz; Sampa Santra; Fred W Peyerl; Georgia R Krivulka; Kristin Beaudry; Michelle A Lifton; Darci A Gorgone; David C Montefiori; Mark G Lewis; Steven Wolinsky; Norman L Letvin
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
Nature 2002;415(6869):335-9.
2002: Paul F McKay; Joern schmitz; Dan H Barouch; Marcelo J Kuroda; Michelle A Lifton; Christine E Nickerson; Darci A Gorgone; Norman L Letvin
Vaccine protection against functional CTL abnormalities in simian human immunodeficiency virus-infected rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):332-7.