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Dirk Görlich

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Chemicals & Drugs

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Molecular Sequence Data

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Publications

TOP 3
Aksana A Labokha; Henning Urlaub; Marc Baldus; Steffen Frey; Sabine Gradmann; Bastian B Hülsmann; Dirk Görlich
Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes.
Bastian B Hülsmann; Aksana A Labokha; Dirk Görlich
The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model.
Marcel Petri; Steffen Frey; Dirk Görlich; Andreas Menzel; Simone Techert
Structural characterization of nanoscale meshworks within a nucleoporin FG hydrogel.

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All Publications

2013: Aksana A Labokha; Henning Urlaub; Marc Baldus; Steffen Frey; Sabine Gradmann; Bastian B Hülsmann; Dirk Görlich
Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes.
The EMBO journal 2013;32(2):204-18.
2012: Bastian B Hülsmann; Aksana A Labokha; Dirk Görlich
The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model.
Cell 2012;150(4):738-51.
2012: Marcel Petri; Steffen Frey; Dirk Görlich; Andreas Menzel; Simone Techert
Structural characterization of nanoscale meshworks within a nucleoporin FG hydrogel.
Biomacromolecules 2012;13(6):1882-9.
2009: Steffen Frey; Dirk Görlich
FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties.
The EMBO journal 2009;28(17):2554-67.
2007: Steffen Frey; Dirk Görlich
A saturated FG-repeat hydrogel can reproduce the permeability properties of nuclear pore complexes.
Cell 2007;130(3):512-23.
2006: Steffen Frey; Ralf P Richter; Dirk Görlich
FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties.
Science (New York, N.Y.) 2006;314(5800):815-7.
2006: Katharina Ribbeck; Aaron C Groen; Rachel Santarella; Markus T Bohnsack; Tim Raemaekers; Thomas Köcher; Marc Gentzel; Dirk Görlich; Matthias Wilm; Geert Carmeliet; Timothy J Mitchison; Jan Ellenberg; Andreas Hoenger; Iain W Mattaj
NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules.
Molecular biology of the cell 2006;17(6):2646-60.
2006: Fabrizia Stavru; Gitte Nautrup-Pedersen; Volker C Cordes; Dirk Görlich
Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells.
The Journal of cell biology 2006;173(4):477-83.
2006: Fabrizia Stavru; Bastian B Hülsmann; Anne Spang; Enno Hartmann; Volker C Cordes; Dirk Görlich
NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes.
The Journal of cell biology 2006;173(4):509-19.
2006: Markus T Bohnsack; Theis Stüven; Christa Kuhn; Volker C Cordes; Dirk Görlich
A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes.
Nature cell biology 2006;8(3):257-63.
2005: Oliver Hantschel; Silke Wiesner; Thomas Güttler; Cameron Mackereth; Lily L Remsing Rix; Zsuzsanna Mikes; Jana Dehne; Dirk Görlich; Michael Sattler; Giulio Superti-Furga
Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl.
Molecular cell 2005;19(4):461-73.
2004: José-Manuel Mingot; Markus T Bohnsack; Ursula Jäkle; Dirk Görlich
Exportin 7 defines a novel general nuclear export pathway.
The EMBO journal 2004;23(16):3227-36.
2003: Theis Stüven; Enno Hartmann; Dirk Görlich
Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.
The EMBO journal 2003;22(21):5928-40.
2003: Ariberto Fassati; Dirk Görlich; Ian Harrison; Lyubov Zaytseva; José-Manuel Mingot
Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7.
The EMBO journal 2003;22(14):3675-85.
2003: Dirk Görlich; Michael J Seewald; Katharina Ribbeck
Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation.
The EMBO journal 2003;22(5):1088-100.
2002: Markus T Bohnsack; Kathrin Regener; Blanche Schwappach; Rainer Saffrich; Efrosyni Paraskeva; Enno Hartmann; Dirk Görlich
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
The EMBO journal 2002;21(22):6205-15.
2002: Katharina Ribbeck; Dirk Görlich
The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion.
The EMBO journal 2002;21(11):2664-71.
2002: Stefan Jäkel; José-Manuel Mingot; Petra Schwarzmaier; Enno Hartmann; Dirk Görlich
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.
The EMBO journal 2002;21(3):377-86.
2001: José-Manuel Mingot; Susanne Kostka; Robert Kraft; Enno Hartmann; Dirk Görlich
Importin 13: a novel mediator of nuclear import and export.
The EMBO journal 2001;20(14):3685-94.
2001: Katharina Ribbeck; Dirk Görlich
Kinetic analysis of translocation through nuclear pore complexes.
The EMBO journal 2001;20(6):1320-30.
2000: M Lippai; László Tirián; Imre Boros; J Mihály; Miklós Erdélyi; I Belecz; E Máthé; J Pósfai; A Nagy; Andor Udvardy; Efrosyni Paraskeva; Dirk Görlich; János Szabad
The Ketel gene encodes a Drosophila homologue of importin-beta.
Genetics 2000;156(4):1889-900.
2000: C I Villa Braslavsky; Christine Nowak; Dirk Görlich; Alfred Wittinghofer; Jürgen Kuhlmann
Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta.
Biochemistry 2000;39(38):11629-39.
2000: G Lipowsky; F Ralf Bischoff; Petra Schwarzmaier; Robert Kraft; Susanne Kostka; Enno Hartmann; Ulrike Kutay; Dirk Görlich
Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.
The EMBO journal 2000;19(16):4362-71.
2000: Angela Bachi; Isabelle C Braun; João Pedro Rodrigues; Nelly Panté; Katharina Ribbeck; C von Kobbe; Ulrike Kutay; Matthias Wilm; Dirk Görlich; Maria Carmo-Fonseca; Elisa Izaurralde
The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.
RNA (New York, N.Y.) 2000;6(1):136-58.
1999: M Köhler; C Speck; M Christiansen; F Ralf Bischoff; Siegfried Prehn; H Haller; Dirk Görlich; Enno Hartmann
Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import.
Molecular and cellular biology 1999;19(11):7782-91.
1999: Bayliss Richard; Katharina Ribbeck; Debra Akin; Helen M Kent; Carl M Feldherr; Dirk Görlich; Murray Stewart
Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP.
Journal of molecular biology 1999;293(3):579-93.
1999: Ingrid R Vetter; A Arndt; Ulrike Kutay; Dirk Görlich; Alfred Wittinghofer
Structural view of the Ran-Importin beta interaction at 2.3 A resolution.
Cell 1999;97(5):635-46.
1999: Stefan Jäkel; Werner Albig; Ulrike Kutay; F Ralf Bischoff; K Schwamborn; Detlef Doenecke; Dirk Görlich
The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.
The EMBO journal 1999;18(9):2411-23.
1999: Efrosyni Paraskeva; Elisa Izaurralde; F Ralf Bischoff; J Huber; Ulrike Kutay; Enno Hartmann; R Lührmann; Dirk Görlich
CRM1-mediated recycling of snurportin 1 to the cytoplasm.
The Journal of cell biology 1999;145(2):255-64.
1999: G Lipowsky; F Ralf Bischoff; Elisa Izaurralde; Ulrike Kutay; S Schäfer; Hans J Gross; Hildburg Beier; Dirk Görlich
Coordination of tRNA nuclear export with processing of tRNA.
RNA (New York, N.Y.) 1999;5(4):539-49.
1999: Katharina Ribbeck; Ulrike Kutay; Efrosyni Paraskeva; Dirk Görlich
The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy.
Current biology : CB 1999;9(1):47-50.
1999: Dirk Görlich; Ulrike Kutay
Transport between the cell nucleus and the cytoplasm.
Annual review of cell and developmental biology 1999;15():607-60.
1998: Katharina Ribbeck; G Lipowsky; Helen M Kent; Murray Stewart; Dirk Görlich
NTF2 mediates nuclear import of Ran.
The EMBO journal 1998;17(22):6587-98.
1998: Stefan Jäkel; Dirk Görlich
Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.
The EMBO journal 1998;17(15):4491-502.
1998: Dirk Görlich
Transport into and out of the cell nucleus.
The EMBO journal 1998;17(10):2721-7.
1998: Ulrike Kutay; G Lipowsky; Elisa Izaurralde; F Ralf Bischoff; Petra Schwarzmaier; Enno Hartmann; Dirk Görlich
Identification of a tRNA-specific nuclear export receptor.
Molecular cell 1998;1(3):359-69.
1997: F Ralf Bischoff; Dirk Görlich
RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors.
FEBS letters 1997;419(2-3):249-54.
1997: Elisa Izaurralde; Ulrike Kutay; C von Kobbe; I W Mattaj; Dirk Görlich
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.
The EMBO journal 1997;16(21):6535-47.
1997: Gabriel Schlenstedt; E Smirnova; R Deane; J Solsbacher; Ulrike Kutay; Dirk Görlich; Herwig Ponstingl; F Ralf Bischoff
Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus.
The EMBO journal 1997;16(20):6237-49.
1997: Ulrike Kutay; F Ralf Bischoff; Susanne Kostka; Robert Kraft; Dirk Görlich
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor.
Cell 1997;90(6):1061-71.
1997: R Deane; W Schäfer; H P Zimmermann; L Mueller; Dirk Görlich; Siegfried Prehn; Herwig Ponstingl; F Ralf Bischoff
Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1.
Molecular and cellular biology 1997;17(9):5087-96.
1997: Dirk Görlich; M Dabrowski; F Ralf Bischoff; Ulrike Kutay; P Bork; Enno Hartmann; Siegfried Prehn; Elisa Izaurralde
A novel class of RanGTP binding proteins.
The Journal of cell biology 1997;138(1):65-80.
1997: Dirk Görlich
Nuclear protein import.
Current opinion in cell biology 1997;9(3):412-9.
1997: Ulrike Kutay; Elisa Izaurralde; F Ralf Bischoff; I W Mattaj; Dirk Görlich
Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.
The EMBO journal 1997;16(6):1153-63.
1996: Ronald A Laskey; Dirk Görlich; Mark A Madine; J P Makkerh; P Romanowski
Regulatory roles of the nuclear envelope.
Experimental cell research 1996;229(2):204-11.
1996: Dirk Görlich; N Panté; Ulrike Kutay; U Aebi; F Ralf Bischoff
Identification of different roles for RanGDP and RanGTP in nuclear protein import.
The EMBO journal 1996;15(20):5584-94.
1996: Dirk Görlich; R Kraft; Susanne Kostka; F Vogel; E Hartmann; Ronald A Laskey; I W Mattaj; Elisa Izaurralde
Importin provides a link between nuclear protein import and U snRNA export.
Cell 1996;87(1):21-32.
1996: J D Lewis; Dirk Görlich; Iain W Mattaj
A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing.
Nucleic acids research 1996;24(17):3332-6.
1996: Dirk Görlich; P Henklein; R A Laskey; E Hartmann
A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus.
The EMBO journal 1996;15(8):1810-7.
1995: Dirk Görlich; F Vogel; Anthony D Mills; E Hartmann; Ronald A Laskey
Distinct functions for the two importin subunits in nuclear protein import.
Nature 1995;377(6546):246-8.
1995: J Oliver; B Jungnickel; Dirk Görlich; T Rapoport; Stephen High
The Sec61 complex is essential for the insertion of proteins into the membrane of the endoplasmic reticulum.
FEBS letters 1995;362(2):126-30.
1995: Dirk Görlich; Susanne Kostka; R Kraft; C Dingwall; Ronald A Laskey; E Hartmann; Siegfried Prehn
Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope.
Current biology : CB 1995;5(4):383-92.
1995: Dirk Görlich; R A Laskey
Roles of importin in nuclear protein import.
Cold Spring Harbor symposia on quantitative biology 1995;60():695-9.
1994: Dirk Görlich; Siegfried Prehn; Ronald A Laskey; E Hartmann
Isolation of a protein that is essential for the first step of nuclear protein import.
Cell 1994;79(5):767-78.
1994: KU Kalies; Dirk Görlich; Tom A Rapoport
Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex.
The Journal of cell biology 1994;126(4):925-34.
1994: E Hartmann; T Sommer; Siegfried Prehn; Dirk Görlich; Stefan Jentsch; Tom A Rapoport
Evolutionary conservation of components of the protein translocation complex.
Nature 1994;367(6464):654-7.
1993: Stephen High; B Martoglio; Dirk Görlich; SS Andersen; Anthony J Ashford; Angelika Giner; E Hartmann; Siegfried Prehn; Tom A Rapoport; Bernhard Dobberstein
Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence.
The Journal of biological chemistry 1993;268(35):26745-51.
1993: Dirk Görlich; Tom A Rapoport
Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane.
Cell 1993;75(4):615-30.
1993: E Hartmann; Dirk Görlich; Susanne Kostka; Albrecht Otto; R Kraft; Siegne Knespel; E Bürger; Tom A Rapoport; Siegfried Prehn
A tetrameric complex of membrane proteins in the endoplasmic reticulum.
European journal of biochemistry / FEBS 1993;214(2):375-81.
1993: Stephen High; SS Andersen; Dirk Görlich; E Hartmann; Siegfried Prehn; Tom A Rapoport; Bernhard Dobberstein
Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion.
The Journal of cell biology 1993;121(4):743-50.
1992: Dirk Görlich; Siegfried Prehn; E Hartmann; KU Kalies; Tom A Rapoport
A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation.
Cell 1992;71(3):489-503.
1992: Dirk Görlich; E Hartmann; Siegfried Prehn; Tom A Rapoport
A protein of the endoplasmic reticulum involved early in polypeptide translocation.
Nature 1992;357(6373):47-52.
1992: Tom A Rapoport; Dirk Görlich; A Müsch; E Hartmann; Siegfried Prehn; M Wiedmann; Albrecht Otto; Susanne Kostka; R Kraft
Components and mechanism of protein translocation across the ER membrane.
Antonie van Leeuwenhoek 1992;61(2):119-22.
1991: Stephen High; Dirk Görlich; M Wiedmann; Tom A Rapoport; Bernhard Dobberstein
The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER.
The Journal of cell biology 1991;113(1):35-44.
1991: Dirk Görlich; T V Kurzchalia; M Wiedmann; Tom A Rapoport
Probing the molecular environment of translocating polypeptide chains by cross-linking.
Methods in cell biology 1991;34():241-62.
1990: Dirk Görlich; Siegfried Prehn; E Hartmann; Joachim Herz; Albrecht Otto; R Kraft; M Wiedmann; Siegne Knespel; Bernhard Dobberstein; Tom A Rapoport
The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents.
The Journal of cell biology 1990;111(6 Pt 1):2283-94.
1990: F Vogel; E Hartmann; Dirk Görlich; Tom A Rapoport
Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane.
European journal of cell biology 1990;53(2):197-202.