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Myriam Gorospe

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Physiology

Gene Expression Regulation

Anatomy

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Mice

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Oligonucleotide Array Sequence Analysis

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Publications

TOP 3
Ale-Agha Niloofar; Galban Stefanie; Sobieroy Christiane; Abdelmohsen Kotb; Gorospe Myriam; Sies Helmut; Klotz Lars-Oliver
HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity.
Kim Hyeon Ho; Kuwano Yuki; Srikantan Subramanya; Lee Eun Kyung; Martindale Jennifer L; Gorospe Myriam
HuR recruits let-7/RISC to repress c-Myc expression.
Figueroa Angélica; Kotani Hirokazu; Toda Yoshinobu; Mazan-Mamczarz Krystyna; Mueller Eva-Christina; Otto Albrecht; Disch Lena; Norman Mark; Ramdasi Rasika Mohan; Keshtgar Mohammed; Gorospe Myriam; Fujita Yasuyuki
Novel roles of hakai in cell proliferation and oncogenesis.

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All Publications

2009: Ale-Agha Niloofar; Galban Stefanie; Sobieroy Christiane; Abdelmohsen Kotb; Gorospe Myriam; Sies Helmut; Klotz Lars-Oliver
HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity.
Hepatology (Baltimore, Md.) 2009;50(5):1567-76.
2009: Kim Hyeon Ho; Kuwano Yuki; Srikantan Subramanya; Lee Eun Kyung; Martindale Jennifer L; Gorospe Myriam
HuR recruits let-7/RISC to repress c-Myc expression.
Genes & development 2009;23(15):1743-8.
2009: Figueroa Angélica; Kotani Hirokazu; Toda Yoshinobu; Mazan-Mamczarz Krystyna; Mueller Eva-Christina; Otto Albrecht; Disch Lena; Norman Mark; Ramdasi Rasika Mohan; Keshtgar Mohammed; Gorospe Myriam; Fujita Yasuyuki
Novel roles of hakai in cell proliferation and oncogenesis.
Molecular biology of the cell 2009;20(15):3533-42.
2009: Andersen Jesper B; Mazan-Mamczarz Krystyna; Zhan Ming; Gorospe Myriam; Hassel Bret A
Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence.
RNA biology 2009;6(3):305-15.
2009: Brennan Sarah E; Kuwano Yuki; Alkharouf Nadim; Blackshear Perry J; Gorospe Myriam; Wilson Gerald M
The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis.
Cancer research 2009;69(12):5168-76.
2009: Abdelmohsen Kotb; Srikantan Subramanya; Yang Xiaoling; Lal Ashish; Kim Hyeon Ho; Kuwano Yuki; Galban Stefanie; Becker Kevin G; Kamara Davida; de Cabo Rafael; Gorospe Myriam
Ubiquitin-mediated proteolysis of HuR by heat shock.
The EMBO journal 2009;28(9):1271-82.
2009: Kuwano Yuki; Rabinovic Ariel; Srikantan Subramanya; Gorospe Myriam; Demple Bruce
Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation.
Molecular and cellular biology 2009;29(10):2622-35.
2009: de Silanes Isabel López; Gorospe Myriam; Taniguchi Hiroaki; Abdelmohsen Kotb; Srikantan Subramanya; Alaminos Miguel; Berdasco María; Urdinguio Rocío G; Fraga Mario F; Jacinto Filipe V; Esteller Manel
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.
Nucleic acids research 2009;37(8):2658-71.
2009: Mazan-Mamczarz Krystyna; Kuwano Yuki; Zhan Ming; White Elizabeth J; Martindale Jennifer L; Lal Ashish; Gorospe Myriam
Identification of a signature motif in target mRNAs of RNA-binding protein AUF1.
Nucleic acids research 2009;37(1):204-14.
2009: Marasa Bernard S; Srikantan Subramanya; Masuda Kiyoshi; Abdelmohsen Kotb; Kuwano Yuki; Yang Xiaoling; Martindale Jennifer L; Rinker-Schaeffer Carrie W; Gorospe Myriam
Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs.
Science signaling 2009;2(94):ra69.
2009: Gorospe Myriam
Ribonucleoprotein dynamics connects mRNA networks with drug mechanisms.
Molecular systems biology 2009;5():289.
2008: Kim Hyeon Ho; Gorospe Myriam
Phosphorylated HuR shuttles in cycles.
Cell cycle (Georgetown, Tex.) 2008;7(20):3124-6.
2008: Mazan-Mamczarz K; Hagner P R; Corl S; Srikantan S; Wood W H; Becker K G; Gorospe M; Keene J D; Levenson A S; Gartenhaus R B
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Oncogene 2008;27(47):6151-63.
2008: Kuwano Yuki; Gorospe Myriam
Protecting the stress response, guarding the MKP-1 mRNA.
Cell cycle (Georgetown, Tex.) 2008;7(17):2640-2.
2008: Chen Jie; Xiao Lan; Rao Jaladanki N; Zou Tongtong; Liu Lan; Bellavance Emily; Gorospe Myriam; Wang Jian-Ying
JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function.
Molecular biology of the cell 2008;19(9):3701-12.
2008: van der Brug Marcel P; Blackinton Jeff; Chandran Jayanth; Hao Ling-Yang; Lal Ashish; Mazan-Mamczarz Krystyna; Martindale Jennifer; Xie Chengsong; Ahmad Rili; Thomas Kelly J; Beilina Alexandra; Gibbs J Raphael; Ding Jinhui; Myers Amanda J; Zhan Ming; Cai Huaibin; Bonini Nancy M; Gorospe Myriam; Cookson Mark R
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10244-9.
2008: Hucl Tomas; Rago Carlo; Gallmeier Eike; Brody Jonathan R; Gorospe Myriam; Kern Scott E
A syngeneic variance library for functional annotation of human variation: application to BRCA2.
Cancer research 2008;68(13):5023-30.
2008: Kim Hyeon Ho; Abdelmohsen Kotb; Lal Ashish; Pullmann Rudolf; Yang Xiaoling; Galban Stefanie; Srikantan Subramanya; Martindale Jennifer L; Blethrow Justin; Shokat Kevan M; Gorospe Myriam
Nuclear HuR accumulation through phosphorylation by Cdk1.
Genes & development 2008;22(13):1804-15.
2008: Kuwano Yuki; Kim Hyeon Ho; Abdelmohsen Kotb; Pullmann Rudolf; Martindale Jennifer L; Yang Xiaoling; Gorospe Myriam
MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90.
Molecular and cellular biology 2008;28(14):4562-75.
2008: Abdelmohsen Kotb; Kuwano Yuki; Kim Hyeon Ho; Gorospe Myriam
Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence.
Biological chemistry 2008;389(3):243-55.
2008: Kim Hyeon Ho; Gorospe Myriam
GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover.
Molecular cell 2008;29(2):151-2.
2008: Gorospe Myriam; de Cabo Rafael
AsSIRTing the DNA damage response.
Trends in cell biology 2008;18(2):77-83.
2008: Galbán Stefanie; Kuwano Yuki; Pullmann Rudolf; Martindale Jennifer L; Kim Hyeon Ho; Lal Ashish; Abdelmohsen Kotb; Yang Xiaoling; Dang Youngjun; Liu Jun O; Lewis Stephen M; Holcik Martin; Gorospe Myriam
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.
Molecular and cellular biology 2008;28(1):93-107.
2008: Zou Tongtong; Liu Lan; Rao Jaladanki N; Marasa Bernard S; Chen Jie; Xiao Lan; Zhou Huiping; Gorospe Myriam; Wang Jian-Ying
Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1.
The Biochemical journal 2008;409(2):389-98.
2008: Lecona Emilio; Olmo Nieves; Turnay Javier; Santiago-Gómez Angélica; López de Silanes Isabel; Gorospe Myriam; Lizarbe M Antonia
Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms.
The Biochemical journal 2008;409(1):311-20.
2008: Lal Ashish; Kim Hyeon Ho; Abdelmohsen Kotb; Kuwano Yuki; Pullmann Rudolf; Srikantan Subramanya; Subrahmanyam Ramesh; Martindale Jennifer L; Yang Xiaoling; Ahmed Fariyal; Navarro Francisco; Dykxhoorn Derek; Lieberman Judy; Gorospe Myriam
p16(INK4a) translation suppressed by miR-24.
PloS one 2008;3(3):e1864.
2007: Zahn Jacob M; Poosala Suresh; Owen Art B; Ingram Donald K; Lustig Ana; Carter Arnell; Weeraratna Ashani T; Taub Dennis D; Gorospe Myriam; Mazan-Mamczarz Krystyna; Lakatta Edward G; Boheler Kenneth R; Xu Xiangru; Mattson Mark P; Falco Geppino; Ko Minoru S H; Schlessinger David; Firman Jeffrey; Kummerfeld Sarah K; Wood William H; Zonderman Alan B; Kim Stuart K; Becker Kevin G
AGEMAP: a gene expression database for aging in mice.
PLoS genetics 2007;3(11):e201.
2007: Xiao Lan; Rao Jaladanki N; Zou Tongtong; Liu Lan; Marasa Bernard S; Chen Jie; Turner Douglas J; Zhou Huiping; Gorospe Myriam; Wang Jian-Ying
Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells.
Molecular biology of the cell 2007;18(11):4579-90.
2007: Kim Henry S; Kuwano Yuki; Zhan Ming; Pullmann Rudolf; Mazan-Mamczarz Krystyna; Li Huai; Kedersha Nancy; Anderson Paul; Wilce Matthew C J; Gorospe Myriam; Wilce Jacqueline A
Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR.
Molecular and cellular biology 2007;27(19):6806-17.
2007: Pullmann Rudolf; Kim Hyeon Ho; Abdelmohsen Kotb; Lal Ashish; Martindale Jennifer L; Yang Xiaoling; Gorospe Myriam
Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs.
Molecular and cellular biology 2007;27(18):6265-78.
2007: Abdelmohsen Kotb; Lal Ashish; Kim Hyeon Ho; Gorospe Myriam
Posttranscriptional orchestration of an anti-apoptotic program by HuR.
Cell cycle (Georgetown, Tex.) 2007;6(11):1288-92.
2007: Abdelmohsen Kotb; Pullmann Rudolf; Lal Ashish; Kim Hyeon Ho; Galban Stefanie; Yang Xiaoling; Blethrow Justin D; Walker Mark; Shubert Jonathan; Gillespie David A; Furneaux Henry; Gorospe Myriam
Phosphorylation of HuR by Chk2 regulates SIRT1 expression.
Molecular cell 2007;25(4):543-57.
2007: Schwartz Elena I; Smilenov Lubomir B; Price Mary A; Osredkar Tracy; Baker Ronald A; Ghosh Soma; Shi Fu-Dong; Vollmer Timothy L; Lencinas Alejandro; Stearns Diane M; Gorospe Myriam; Kruman Inna I
Cell cycle activation in postmitotic neurons is essential for DNA repair.
Cell cycle (Georgetown, Tex.) 2007;6(3):318-29.
2006: Dang Yongjun; Kedersha Nancy; Low Woon-Kai; Romo Daniel; Gorospe Myriam; Kaufman Randal; Anderson Paul; Liu Jun O
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A.
The Journal of biological chemistry 2006;281(43):32870-8.
2006: Tanaka Tetsuya S; Lopez de Silanes Isabel; Sharova Lioudmila V; Akutsu Hidenori; Yoshikawa Toshiyuki; Amano Hisayuki; Yamanaka Shinya; Gorospe Myriam; Ko Minoru S H
Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets.
Development, growth & differentiation 2006;48(6):381-90.
2006: Pullmann Rudolf; Abdelmohsen Kotb; Lal Ashish; Martindale Jennifer L; Ladner Robert D; Gorospe Myriam
Differential stability of thymidylate synthase 3'-untranslated region polymorphic variants regulated by AUF1.
The Journal of biological chemistry 2006;281(33):23456-63.
2006: Lal Ashish; Gorospe Myriam
Egad, more forms of gene regulation: the gadd45a story.
Cell cycle (Georgetown, Tex.) 2006;5(13):1422-5.
2006: Zou Tongtong; Mazan-Mamczarz Krystyna; Rao Jaladanki N; Liu Lan; Marasa Bernard S; Zhang Ai-Hong; Xiao Lan; Pullmann Rudolf; Gorospe Myriam; Wang Jian-Ying
Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs.
The Journal of biological chemistry 2006;281(28):19387-94.
2006: Smith Wanli W; Gorospe Myriam; Kusiak John W
Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease.
CNS & neurological disorders drug targets 2006;5(3):355-61.
2006: Gallmeier Eike; Calhoun Eric S; Rago Carlo; Brody Jonathan R; Cunningham Steven C; Hucl Tomas; Gorospe Myriam; Kohli Manu; Lengauer Christoph; Kern Scott E
Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.
Gastroenterology 2006;130(7):2145-54.
2006: Cunningham Steven C; Gallmeier Eike; Hucl Tomas; Dezentje David A; Calhoun Eric S; Falco Geppino; Abdelmohsen Kotb; Gorospe Myriam; Kern Scott E
Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss.
Cancer research 2006;66(11):5560-4.
2006: Cunningham Steven C; Gallmeier Eike; Hucl Tomas; Dezentje David A; Abdelmohsen Kotb; Gorospe Myriam; Kern Scott E
Theoretical proposal: allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers.
Cell cycle (Georgetown, Tex.) 2006;5(10):1090-3.
2006: Lal Ashish; Abdelmohsen Kotb; Pullmann Rudolf; Kawai Tomoko; Galban Stefanie; Yang Xiaoling; Brewer Gary; Gorospe Myriam
Posttranscriptional derepression of GADD45alpha by genotoxic stress.
Molecular cell 2006;22(1):117-28.
2006: Kawai Tomoko; Lal Ashish; Yang Xiaoling; Galban Stefanie; Mazan-Mamczarz Krystyna; Gorospe Myriam
Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.
Molecular and cellular biology 2006;26(8):3295-307.
2006: Mazan-Mamczarz Krystyna; Lal Ashish; Martindale Jennifer L; Kawai Tomoko; Gorospe Myriam
Translational repression by RNA-binding protein TIAR.
Molecular and cellular biology 2006;26(7):2716-27.
2006: Fan Jinshui; Zhan Ming; Shen Jikui; Martindale Jennifer L; Yang Xiaoling; Kawai Tomoko; Gorospe Myriam
En masse nascent transcription analysis to elucidate regulatory transcription factors.
Nucleic acids research 2006;34(5):1492-500.
2005: Lal Ashish; Haynes Susan R; Gorospe Myriam
Clean Western blot signals from immunoprecipitated samples.
Molecular and cellular probes 2005;19(6):385-8.
2005: Cheadle Chris; Fan Jinshui; Cho-Chung Yoon S; Werner Thomas; Ray Jill; Do Lana; Gorospe Myriam; Becker Kevin G
Stability regulation of mRNA and the control of gene expression.
Annals of the New York Academy of Sciences 2005;1058():196-204.
2005: Fan J; Heller N M; Gorospe M; Atasoy U; Stellato C
The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;26(5):933-47.
2005: López de Silanes Isabel; Galbán Stefanie; Martindale Jennifer L; Yang Xiaoling; Mazan-Mamczarz Krystyna; Indig Fred E; Falco Geppino; Zhan Ming; Gorospe Myriam
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.
Molecular and cellular biology 2005;25(21):9520-31.
2005: Mazan-Mamczarz Krystyna; Kawai Tomoko; Martindale Jennifer L; Gorospe Myriam
En masse analysis of nascent translation using microarrays.
BioTechniques 2005;39(1):61-2, 64, 66-7.
2005: Pullmann Rudolf; Juhaszova Magdalena; López de Silanes Isabel; Kawai Tomoko; Mazan-Mamczarz Krystyna; Halushka Marc K; Gorospe Myriam
Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR.
The Journal of biological chemistry 2005;280(24):22819-26.
2005: Lal Ashish; Kawai Tomoko; Yang Xiaoling; Mazan-Mamczarz Krystyna; Gorospe Myriam
Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha.
The EMBO journal 2005;24(10):1852-62.
2005: Smith Wanli W; Norton Darrell D; Gorospe Myriam; Jiang Haibing; Nemoto Shino; Holbrook Nikki J; Finkel Toren; Kusiak John W
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
The Journal of cell biology 2005;169(2):331-9.
2005: Wang Wengong; Martindale Jennifer L; Yang Xiaoling; Chrest Francis J; Gorospe Myriam
Increased stability of the p16 mRNA with replicative senescence.
EMBO reports 2005;6(2):158-64.
2005: López de Silanes Isabel; Lal Ashish; Gorospe Myriam
HuR: post-transcriptional paths to malignancy.
RNA biology 2005;2(1):11-3.
2005: Cheadle Chris; Fan Jinshui; Cho-Chung Yoon S; Werner Thomas; Ray Jill; Do Lana; Gorospe Myriam; Becker Kevin G
Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability.
BMC genomics 2005;6(1):75.
2004: Yang Xiaoling; Wang Wengong; Fan Jinshui; Lal Ashish; Yang Dongmei; Cheng Heping; Gorospe Myriam
Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR.
The Journal of biological chemistry 2004;279(47):49298-306.
2004: Wang Wengong; Yang Xiaoling; Kawai Tomoko; López de Silanes Isabel; Mazan-Mamczarz Krystyna; Chen Peili; Chook Yuh Min; Quensel Christina; Köhler Matthias; Gorospe Myriam
AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR.
The Journal of biological chemistry 2004;279(46):48376-88.
2004: Lal Ashish; Mazan-Mamczarz Krystyna; Kawai Tomoko; Yang Xiaoling; Martindale Jennifer L; Gorospe Myriam
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs.
The EMBO journal 2004;23(15):3092-102.
2004: Kawai Tomoko; Fan Jinshui; Mazan-Mamczarz Krystyna; Gorospe Myriam
Global mRNA stabilization preferentially linked to translational repression during the endoplasmic reticulum stress response.
Molecular and cellular biology 2004;24(15):6773-87.
2004: López de Silanes Isabel; Olmo Nieves; Turnay Javier; González de Buitrago Gonzalo; Pérez-Ramos Pablo; Guzmán-Aránguez Ana; García-Díez Marta; Lecona Emilio; Gorospe Myriam; Lizarbe M Antonia
Acquisition of resistance to butyrate enhances survival after stress and induces malignancy of human colon carcinoma cells.
Cancer research 2004;64(13):4593-600.
2004: Cohen Haim Y; Miller Christine; Bitterman Kevin J; Wall Nathan R; Hekking Brian; Kessler Benedikt; Howitz Konrad T; Gorospe Myriam; de Cabo Rafael; Sinclair David A
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Science (New York, N.Y.) 2004;305(5682):390-2.
2004: López de Silanes Isabel; Zhan Ming; Lal Ashish; Yang Xiaoling; Gorospe Myriam
Identification of a target RNA motif for RNA-binding protein HuR.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2987-92.
2004: Kruman Inna I; Wersto Robert P; Cardozo-Pelaez Fernando; Smilenov Lubomir; Chan Sic L; Chrest Francis J; Emokpae Roland; Gorospe Myriam; Mattson Mark P
Cell cycle activation linked to neuronal cell death initiated by DNA damage.
Neuron 2004;41(4):549-61.
2004: López de Silanes Isabel; Fan Jinshui; Galbán Craig J; Spencer Richard G; Becker Kevin G; Gorospe Myriam
Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity.
Gene expression 2004;12(1):49-59.
2003: Seminario Maria-Cristina; Precht Patricia; Wersto Robert P; Gorospe Myriam; Wange Ronald L
PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression.
Oncogene 2003;22(50):8195-204.
2003: López de Silanes Isabel; Fan Jinshui; Yang Xiaoling; Zonderman Alan B; Potapova Olga; Pizer Ellen S; Gorospe Myriam
Role of the RNA-binding protein HuR in colon carcinogenesis.
Oncogene 2003;22(46):7146-54.
2003: Atasoy Ulus; Curry Stephanie L; López de Silanes Isabel; Shyu Ann-Bin; Casolaro Vincenzo; Gorospe Myriam; Stellato Cristiana
Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4369-78.
2003: Galbán Stefanie; Martindale Jennifer L; Mazan-Mamczarz Krystyna; López de Silanes Isabel; Fan Jinshui; Wang Wengong; Decker Jochen; Gorospe Myriam
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells.
Molecular and cellular biology 2003;23(20):7083-95.
2003: Gorospe Myriam
HuR in the mammalian genotoxic response: post-transcriptional multitasking.
Cell cycle (Georgetown, Tex.) 2003;2(5):412-4.
2003: Figueroa Angélica; Cuadrado Ana; Fan Jinshui; Atasoy Ulus; Muscat George E; Muñoz-Canoves Pura; Gorospe Myriam; Muñoz Alberto
Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes.
Molecular and cellular biology 2003;23(14):4991-5004.
2003: Mazan-Mamczarz Krystyna; Galbán Stefanie; López de Silanes Isabel; Martindale Jennifer L; Atasoy Ulus; Keene Jack D; Gorospe Myriam
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8354-9.
2003: Wang Wengong; Yang Xiaoling; López de Silanes Isabel; Carling David; Gorospe Myriam
Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function.
The Journal of biological chemistry 2003;278(29):27016-23.
2003: de Cabo Rafael; Fürer-Galbán Stefanie; Anson R Michael; Gilman Charles; Gorospe Myriam; Lane Mark A
An in vitro model of caloric restriction.
Experimental gerontology 2003;38(6):631-9.
2003: Ikeyama Shizuo; Wang Xian-Tao; Li Ji; Podlutsky Andrej; Martindale Jennifer L; Kokkonen Gertrude; van Huizen Rika; Gorospe Myriam; Holbrook Nikki J
Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury.
The Journal of biological chemistry 2003;278(19):16726-31.
2003: van Huizen Rika; Martindale Jennifer L; Gorospe Myriam; Holbrook Nikki J
P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling.
The Journal of biological chemistry 2003;278(18):15558-64.
2003: Ikeyama Shizuo; Kokkonen Gertrude; Martindale Jennifer L; Wang Xian-Tao; Gorospe Myriam; Holbrook Nikki J
Effects of aging and calorie restriction of Fischer 344 rats on hepatocellular response to proliferative signals.
Experimental gerontology 2003;38(4):431-9.
2003: Shack Sonsoles; Wang Xian-Tao; Kokkonen Gertrude C; Gorospe Myriam; Longo Dan L; Holbrook Nikki J
Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity.
Molecular and cellular biology 2003;23(7):2407-14.
2003: Galbán Stefanie; Fan Jinshui; Martindale Jennifer L; Cheadle Chris; Hoffman Bryan; Woods Michael P; Temeles Gretchen; Brieger Jürgen; Decker Jochen; Gorospe Myriam
von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays.
Molecular and cellular biology 2003;23(7):2316-28.
2003: Li Ji; Gorospe Myriam; Barnes Janice; Liu Yusen
Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.
The Journal of biological chemistry 2003;278(15):13183-91.
2003: Ambrosino Concetta; Mace Gaetane; Galban Stefanie; Fritsch Cornelius; Vintersten Kristina; Black Emma; Gorospe Myriam; Nebreda Angel R
Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase.
Molecular and cellular biology 2003;23(1):370-81.
2002: Li Ji; Chen Peili; Sinogeeva Natasha; Gorospe Myriam; Wersto Robert P; Chrest Francis J; Barnes Janice; Liu Yusen
Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells.
The Journal of biological chemistry 2002;277(51):49504-10.
2002: Fan Jinshui; Yang Xiaoling; Wang Wengong; Wood William H; Becker Kevin G; Gorospe Myriam
Global analysis of stress-regulated mRNA turnover by using cDNA arrays.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10611-6.
2002: Potapova Olga; Anisimov Sergey V; Gorospe Myriam; Dougherty Ryan H; Gaarde William A; Boheler Kenneth R; Holbrook Nikki J
Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression.
Cancer research 2002;62(11):3257-63.
2002: Wang Wengong; Fan Jinshui; Yang Xiaoling; Fürer-Galban Stefanie; Lopez de Silanes Isabel; von Kobbe Cayetano; Guo Jia; Georas Steve N; Foufelle Fabienne; Hardie D Grahame; Carling David; Gorospe Myriam
AMP-activated kinase regulates cytoplasmic HuR.
Molecular and cellular biology 2002;22(10):3425-36.
2002: Caldwell M Craig; Hough Colleen; Fürer Stefanie; Linehan W Marston; Morin Patrice J; Gorospe Myriam
Serial analysis of gene expression in renal carcinoma cells reveals VHL-dependent sensitivity to TNFalpha cytotoxicity.
Oncogene 2002;21(6):929-36.
2001: Li J; Gorospe M; Hutter D; Barnes J; Keyse S M; Liu Y
Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.
Molecular and cellular biology 2001;21(23):8213-24.
2001: Wang W; Yang X; Cristofalo V J; Holbrook N J; Gorospe M
Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence.
Molecular and cellular biology 2001;21(17):5889-98.
2001: Chen P; Hutter D; Yang X; Gorospe M; Davis R J; Liu Y
Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically.
The Journal of biological chemistry 2001;276(31):29440-9.
2001: Li J N; Gorospe M; Chrest F J; Kumaravel T S; Evans M K; Han W F; Pizer E S
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
Cancer research 2001;61(4):1493-9.
2000: Arrington E D; Caldwell M C; Kumaravel T S; Lohani A; Joshi A; Evans M K; Chen H T; Nussenzweig A; Holbrook N J; Gorospe M
Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects.
Free radical biology & medicine 2000;29(11):1166-76.
2000: Lin S; Wang W; Wilson G M; Yang X; Brewer G; Holbrook N J; Gorospe M
Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover.
Molecular and cellular biology 2000;20(21):7903-13.
2000: Potapova O; Gorospe M; Bost F; Dean N M; Gaarde W A; Mercola D; Holbrook N J
c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells.
The Journal of biological chemistry 2000;275(32):24767-75.
2000: Wang W; Caldwell M C; Lin S; Furneaux H; Gorospe M
HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation.
The EMBO journal 2000;19(10):2340-50.
2000: Potapova O; Gorospe M; Dougherty R H; Dean N M; Gaarde W A; Holbrook N J
Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner.
Molecular and cellular biology 2000;20(5):1713-22.
2000: Wang W; Furneaux H; Cheng H; Caldwell M C; Hutter D; Liu Y; Holbrook N; Gorospe M
HuR regulates p21 mRNA stabilization by UV light.
Molecular and cellular biology 2000;20(3):760-9.
1999: Shack S; Gorospe M; Fawcett T W; Hudgins W R; Holbrook N J
Activation of the cholesterol pathway and Ras maturation in response to stress.
Oncogene 1999;18(44):6021-8.
1999: Gorospe M; Egan J M; Zbar B; Lerman M; Geil L; Kuzmin I; Holbrook N J
Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells.
Molecular and cellular biology 1999;19(2):1289-300.
1999: Gorospe M; Wang X; Holbrook N J
Functional role of p21 during the cellular response to stress.
Gene expression 1999;7(4-6):377-85.
1998: Guyton K Z; Gorospe M; Wang X; Mock Y D; Kokkonen G C; Liu Y; Roth G S; Holbrook N J
Age-related changes in activation of mitogen-activated protein kinase cascades by oxidative stress.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1998;3(1):23-7.
1998: Liu Y; Gorospe M; Kokkonen G C; Boluyt M O; Younes A; Mock Y D; Wang X; Roth G S; Holbrook N J
Impairments in both p70 S6 kinase and extracellular signal-regulated kinase signaling pathways contribute to the decline in proliferative capacity of aged hepatocytes.
Experimental cell research 1998;240(1):40-8.
1998: Gorospe M; Wang X; Holbrook N J
p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system.
Molecular and cellular biology 1998;18(3):1400-7.
1997: Wang X; Gorospe M; Huang Y; Holbrook N J
p27Kip1 overexpression causes apoptotic death of mammalian cells.
Oncogene 1997;15(24):2991-7.
1997: Xu Q; Fawcett T W; Gorospe M; Guyton K Z; Liu Y; Holbrook N J
Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension.
Hypertension 1997;30(1 Pt 1):106-11.
1997: Gorospe M; Cirielli C; Wang X; Seth P; Capogrossi M C; Holbrook N J
p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells.
Oncogene 1997;14(8):929-35.
1996: Gorospe M; Shack S; Guyton K Z; Samid D; Holbrook N J
Up-regulation and functional role of p21Waf1/Cip1 during growth arrest of human breast carcinoma MCF-7 cells by phenylacetate.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(12):1609-15.
1996: Gorospe M; Wang X; Guyton K Z; Holbrook N J
Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells.
Molecular and cellular biology 1996;16(12):6654-60.
1996: Guyton K Z; Gorospe M; Kensler T W; Holbrook N J
Mitogen-activated protein kinase (MAPK) activation by butylated hydroxytoluene hydroperoxide: implications for cellular survival and tumor promotion.
Cancer research 1996;56(15):3480-5.
1996: Gorospe M; Liu Y; Xu Q; Chrest F J; Holbrook N J
Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2.
Molecular and cellular biology 1996;16(3):762-70.
1996: Yang C; Chang J; Gorospe M; Passaniti A
Protein tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(2):161-71.
1996: Liu Y; Guyton K Z; Gorospe M; Xu Q; Kokkonen G C; Mock Y D; Roth G S; Holbrook N J
Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes.
The Journal of biological chemistry 1996;271(7):3604-7.
1996: Guyton K Z; Liu Y; Gorospe M; Xu Q; Holbrook N J
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury.
The Journal of biological chemistry 1996;271(8):4138-42.
1996: Gorospe M; Holbrook N J
Role of p21 in prostaglandin A2-mediated cellular arrest and death.
Cancer research 1996;56(3):475-9.
1996: Xu Q; Liu Y; Gorospe M; Udelsman R; Holbrook N J
Acute hypertension activates mitogen-activated protein kinases in arterial wall.
The Journal of clinical investigation 1996;97(2):508-14.
1996: Liu Y; Martindale J L; Gorospe M; Holbrook N J
Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway.
Cancer research 1996;56(1):31-5.
1996: Liu Y; Guyton K Z; Gorospe M; Xu Q; Lee J C; Holbrook N J
Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite.
Free radical biology & medicine 1996;21(6):771-81.

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