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Frans Gorus

Research Profile

Disorders

Type 1 Diabetes Mellitus

Chemicals & Drugs

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Belgium

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Islets of Langerhans Transplantation

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TOP 3
Farah T van Genderen; Frans K Gorus; Daniel G Pipeleers; Chris Van Schravendijk
Sensitive and Specific Time-Resolved Fluorescence Immunoassay of Rat C-Peptide for Measuring Hormone Secretory and Storage Capacity of β-Cells In Vivo and In Vitro.
Eric Mbunwe; Daniël Pipeleers; Sara Van Aken; Annelien Van Dalem; Bart J R Van der Auwera; Chris Van Schravendijk; Ilse Vermeulen; Ilse Weets; Janet M Wenzlau; Eric V Balti; Jean De Schepper; Simke Demeester; Luc Derdelinckx; Harry Dorchy; Frans K Gorus; John C Hutton
HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients.
L Jiang; Zhidong Ling; L Aigner; B Brackeva; O Costa; Sebastien Couillard-Després; Frans K Gorus; Daniel Pipeleers; P Rotheneichner; Geert Stangé; Chris Van Schravendijk; K Verhaeghen; Geert A Martens
LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro.

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2013: Farah T van Genderen; Frans K Gorus; Daniel G Pipeleers; Chris Van Schravendijk
Sensitive and Specific Time-Resolved Fluorescence Immunoassay of Rat C-Peptide for Measuring Hormone Secretory and Storage Capacity of β-Cells In Vivo and In Vitro.
Endocrinology 2013;154(5):1934-9.
2013: Eric Mbunwe; Daniël Pipeleers; Sara Van Aken; Annelien Van Dalem; Bart J R Van der Auwera; Chris Van Schravendijk; Ilse Vermeulen; Ilse Weets; Janet M Wenzlau; Eric V Balti; Jean De Schepper; Simke Demeester; Luc Derdelinckx; Harry Dorchy; Frans K Gorus; John C Hutton
HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients.
Diabetes 2013;62(4):1345-50.
2013: L Jiang; Zhidong Ling; L Aigner; B Brackeva; O Costa; Sebastien Couillard-Després; Frans K Gorus; Daniel Pipeleers; P Rotheneichner; Geert Stangé; Chris Van Schravendijk; K Verhaeghen; Geert A Martens
LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro.
Journal of proteomics 2013;80():268-80.
2013: Frans K Gorus; John C Hutton; T Mouraux; Daniel G Pipeleers; Sylvie Tenoutasse; A Van Dalem; I Vermeulen; Ilse Weets; Janet M Wenzlau; E V Balti; O Costa; Christophe E M De Block; Katelijn Decochez; S Demeester; H Dorchy; P Gillard
Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients.
Clinical and experimental immunology 2013;171(1):82-90.
2012: Volkert A L Huurman; Bart Keymeulen; Daniel G Pipeleers; Dave L Roelen; F H J Claas; Gaby Duinkerken; Pieter Gillard; Frans K Gorus; Robert Hilbrands; E P M W van der Meer-Prins; C R van der Torren; Bart O Roep
Immune responses against islet allografts during tapering of immunosuppression--a pilot study in 5 subjects.
Clinical and experimental immunology 2012;169(2):190-8.
2012: Jan Czyzyk; Enric Esplugues; Christine Fedorchuk; Frans K Gorus; Octavian Henegariu; Kevan Herold; Paula Preston-Hurlburt; Raman Baldzizhar; Kim Bottomly; Richard A Flavell
Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6319-27.
2012: I Vermeulen; Ilse Weets; J Wenzlau; M Asanghanwa; K Casteels; O Costa; Katelijn Decochez; Frans K Gorus; John C Hutton; Daniel G Pipeleers; J Ruige; K Verhaeghen
An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age.
Diabetologia 2012;55(2):413-20.
2012: Dorien Van den Bossche; Evilien Vekens; Dieter De Smet; Frans K Gorus; Johan Schiettecatte; Geert A Martens
Enzymatic pyruvate measurement by Cobas 6000 open channel assay.
Clinical laboratory 2012;58(9-10):1091-5.
2011: Ilse Vermeulen; Ilse Weets; Janet M Wenzlau; Milca Asanghanwa; Frans K Gorus; John C Hutton; Bart Keymeulen; Vito Lampasona; Chantal Mathieu; Daniel G Pipeleers; Johannes Ruige; Luc Van Gaal
Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age.
Diabetes care 2011;34(8):1760-5.
2011: Geert A Martens; Finn C Nielsen; Frans K Gorus; Harry Heimberg; Karine Hellemans; Lei Jiang; Olivier Sand; Geert Stangé; Jacques Van Helden; Frans Schuit; Leentje Van Lommel; Daniel G Pipeleers
Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.
PloS one 2011;6(9):e24134.
2010: Dieter De Smet; Geert A Martens; Bram Vanden Berghe; Marc Meysman; Olivier Heylen; Frans K Gorus; Marc De Waele
Use of likelihood ratios improves interpretation of laboratory testing for pulmonary sarcoidosis.
American journal of clinical pathology 2010;134(6):939-47.
2010: Folefac Aminkeng; Ilse Weets; Jan E Van Autreve; Bobby P C Koeleman; Erik Quartier; Chris Van Schravendijk; Frans K Gorus; Bart J R Van der Auwera
Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population.
Human immunology 2010;71(12):1233-7.
2010: Farah T van Genderen; Frans K Gorus; Ilse Vermeulen; Evilien M F Vekens; Pieter De Pauw; Daniel G Pipeleers; Chris Van Schravendijk
Development of a multipurpose time-resolved fluorescence immunoassay for rat insulin.
Analytical biochemistry 2010;404(1):8-13.
2010: Peter In't Veld; Neelke De Munck; Kristien Van Belle; Nicole Buelens; Zhidong Ling; Ilse Weets; Patrick Haentjens; Miriam Pipeleers-Marichal; Frans K Gorus; Daniel Pipeleers
Beta-cell replication is increased in donor organs from young patients after prolonged life support.
Diabetes 2010;59(7):1702-8.
2010: Bart Keymeulen; M Walter; Chantal Mathieu; Leonard Kaufman; Frans K Gorus; R Hilbrands; Evy Vandemeulebroucke; U Van de Velde; L Crenier; Christophe E M De Block; S Candon; H Waldmann; Anette-G Ziegler; L Chatenoud; Daniel Pipeleers
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.
Diabetologia 2010;53(4):614-23.
2010: Joeri De Grijse; M Asanghanwa; B Nouthe; N Albrecher; P Goubert; I Vermeulen; S Van Der Meeren; Katelijn Decochez; Ilse Weets; Bart Keymeulen; V Lampasona; J Wenzlau; J C Hutton; Daniel Pipeleers; Frans K Gorus
Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials.
Diabetologia 2010;53(3):517-24.
2010: Geert A Martens; Lei Jiang; Katrijn Verhaeghen; Joanne B Connolly; Scott G Geromanos; Geert Stangé; Laurence Van Oudenhove; Bart Devreese; Karine Hellemans; Zhidong Ling; Christiaan Van Schravendijk; Daniel G Pipeleers; Johannes P C Vissers; Frans K Gorus
Protein markers for insulin-producing beta cells with higher glucose sensitivity.
PloS one 2010;5(12):e14214.
2010: Evy Vandemeulebroucke; Bart Keymeulen; Katelijn Decochez; Ilse Weets; Christophe E M De Block; Francoise Féry; U Van de Velde; I Vermeulen; Pieter De Pauw; Chantal Mathieu; Daniel G Pipeleers; Frans K Gorus
Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients.
Diabetologia 2010;53(1):36-44.
2009: Robert Hilbrands; Volkert A L Huurman; Pieter Gillard; Jurjen H L Velthuis; Marc De Waele; Chantal Mathieu; Leonard Kaufman; Miriam Pipeleers-Marichal; Zhidong Ling; Babak Movahedi; Daniel Jacobs-Tulleneers-Thevissen; Diethard Monbaliu; Dirk Ysebaert; Frans K Gorus; Bart O Roep; Daniel G Pipeleers; Bart Keymeulen
Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients.
Diabetes 2009;58(10):2267-76.
2009: Evy Vandemeulebroucke; Frans K Gorus; Katelijn Decochez; Ilse Weets; Bart Keymeulen; Christophe E M De Block; J Tits; Daniel G Pipeleers; Chantal Mathieu
Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients.
Diabetes & metabolism 2009;35(4):319-27.
2009: Folefac Aminkeng; Jan E Van Autreve; Ilse Weets; Erik Quartier; Chris Van Schravendijk; Frans K Gorus; Bart J R Van der Auwera
IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population.
Human immunology 2009;70(9):706-10.
2009: Pieter De Pauw; R B Mackin; P Goubert; Chris Van Schravendijk; Frans K Gorus
Total error profiling of a proinsulin time-resolved fluorescence immunoassay.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(23):2403-6.
2008: Pieter De Pauw; Ilse Vermeulen; Ogonnaya C Ubani; I Truyen; Evilien M F Vekens; Farah T van Genderen; Joeri W De Grijse; Daniel G Pipeleers; Chris Van Schravendijk; Frans K Gorus
Simultaneous measurement of plasma concentrations of proinsulin and C-peptide and their ratio with a trefoil-type time-resolved fluorescence immunoassay.
Clinical chemistry 2008;54(12):1990-8.
2008: Daniel Pipeleers; M Chintinne; B Denys; Guy Martens; Bart Keymeulen; Frans K Gorus
Restoring a functional beta-cell mass in diabetes.
Diabetes, obesity & metabolism 2008;10 Suppl 4():54-62.
2008: Pieter Gillard; Zhidong Ling; Chantal Mathieu; laurent crenier; Matthias Lannoo; Bart Maes; Bart Roep; Frans K Gorus; Daniel Pipeleers; Bart Keymeulen
Comparison of sirolimus alone with sirolimus plus tacrolimus in type 1 diabetic recipients of cultured islet cell grafts.
Transplantation 2008;85(2):256-63.
2008: Daniel Pipeleers; Peter in't Veld; Miriam Pipeleers-Marichal; Frans K Gorus
The beta cell population in type 1 diabetes.
Novartis Foundation symposium 2008;292():19-24; discussion 24-31, 122-9, 202-3.
2008: Volkert A L Huurman; Robert Hilbrands; Gabriëlle G M Pinkse; Pieter Gillard; Gaby Duinkerken; Pieter van de Linde; Petronella M W van der Meer-Prins; Minke F J Versteeg-van der Voort Maarschalk; Koen Verbeeck; Behrooz Alizadeh; Chantal Mathieu; Frans K Gorus; Dave L Roelen; Frans H J Claas; Bart Keymeulen; Daniel G Pipeleers; Bart O Roep
Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.
PloS one 2008;3(6):e2435.
2008: Frans K Gorus
[Epidemiology, prediction and prevention of type 1 diabetes: not one fiction in Belgium].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2008;70(1):5-24.
2008: Geert A Martens; Joeri De Nayer; Dieter De Smet; Pedro Couck; Frans K Gorus; Erik Gerlo
Homocysteine measurement by Vitros Microtip homocysteine assay.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(2):283-6.
2007: Timothy Ghys; Wim Goedhuys; Katrien Spincemaille; Frans K Gorus; Erik Gerlo
Plasma-equivalent glucose at the point-of-care: evaluation of Roche Accu-Chek Inform and Abbott Precision PCx glucose meters.
Clinica chimica acta; international journal of clinical chemistry 2007;386(1-2):63-8.
2007: I Truyen; Joeri De Grijse; Chris Van Schravendijk; D De Smet; Katelijn Decochez; Evy Vandemeulebroucke; M Giri; Bart Keymeulen; Chantal Mathieu; Luc Van Gaal; Pieter De Pauw; Ilse Weets; Daniel G Pipeleers; Frans K Gorus
Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives.
Diabetologia 2007;50(10):2143-6.
2007: Peter in't Veld; Dirk lievens; Joeri De Grijse; Zhidong Ling; Bart J R Van der Auwera; Miriam Pipeleers-Marichal; Frans K Gorus; Daniel Pipeleers
Screening for insulitis in adult autoantibody-positive organ donors.
Diabetes 2007;56(9):2400-4.
2007: Folefac Aminkeng; Jan E Van Autreve; Bobby P C Koeleman; Erik Quartier; Chris Van Schravendijk; Frans K Gorus; Bart J R Van der Auwera
TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ.
Human immunology 2007;68(8):690-7.
2007: I Truyen; Joeri De Grijse; Ilse Weets; Leonard Kaufman; L Pipeleers; N Nanos; Katelijn Decochez; Robert Hilbrands; J-M Kaufman; Bart Keymeulen; Chantal Mathieu; Luc Van Gaal; Daniel G Pipeleers; Frans K Gorus
Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes.
Clinical and experimental immunology 2007;149(2):243-50.
2007: Mao Rui; Christiane S Hampe; Chen Wang; Zhidong Ling; Frans K Gorus; Ake Lernmark; Daniel G Pipeleers; Pieter De Pauw
Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.
Journal of immunological methods 2007;319(1-2):133-43.
2006: Bart Keymeulen; Pieter Gillard; Chantal Mathieu; Babak Movahedi; Geert Maleux; Georges Delvaux; Dirk Ysebaert; Bart Roep; Evy Vandemeulebroucke; Miriam Marichal; Peter In 't Veld; Marika Bogdani; Christel Hendrieckx; Frans K Gorus; Zhidong Ling; Jon van Rood; Daniel Pipeleers
Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17444-9.
2006: Ilse Weets; I Truyen; I Verschraegen; Bart J R Van der Auwera; Jean De Schepper; H Dorchy; M-C Lebrethon; Luc Van Gaal; P Van Rooy; Daniel G Pipeleers; Frans K Gorus
Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes.
Diabetologia 2006;49(6):1158-62.
2006: Pedro Couck; Timothy Ghys; Evelyne Van Gastel; Mia Van Coillie; Frans K Gorus; Erik Gerlo
Preliminary performance evaluation of blood gas analyzers.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2006;44(8):1030-4.
2006: Jan E Van Autreve; Bobby P C Koeleman; Erik Quartier; Folefac Aminkeng; Ilse Weets; Frans K Gorus; Bart J R Van der Auwera
MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ.
Human immunology 2006;67(1-2):94-101.
2006: Frans K Gorus; Chantal Mathieu; Erik Gerlo
How should HbA1c measurements be reported?
Diabetologia 2006;49(1):7-10.
2005: I Truyen; Pieter De Pauw; P N Jørgensen; Chris Van Schravendijk; O Ubani; Katelijn Decochez; Evy Vandemeulebroucke; Ilse Weets; R Mao; Daniel G Pipeleers; Frans K Gorus
Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes.
Diabetologia 2005;48(11):2322-9.
2005: Bart Keymeulen; Evy Vandemeulebroucke; Anette-G Ziegler; Chantal Mathieu; Leonard Kaufman; Geoff Hale; Frans K Gorus; Michel Goldman; Markus Walter; Sophie Candon; Liliane Schandene; laurent crenier; Christophe E M De Block; Jean-Marie Seigneurin; Pieter De Pauw; Denis Pierard; Ilse Weets; Peppy Rebello; Pru Bird; Eleanor Berrie; Mark Frewin; Herman Waldmann; Jean-François Bach; Daniel Pipeleers; Lucienne Chatenoud
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
The New England journal of medicine 2005;352(25):2598-608.
2005: Ilse Weets; I Truyen; J C Philips; Frans K Gorus
[Early diagnosis and prevention of type 1 diabetes: role of the Belgian Diabetes Registry].
Revue médicale de Liège 2005;60(5-6):306-12.
2005: Katelijn Decochez; I Truyen; Bart J R Van der Auwera; Ilse Weets; Evy Vandemeulebroucke; Ivo H De Leeuw; Bart Keymeulen; Chantal Mathieu; Raoul Rottiers; Daniel G Pipeleers; Frans K Gorus
Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes.
Diabetologia 2005;48(4):687-94.
2005: Karin Vanderkerken; Kewal Asosingh; Angelo Willems; Hendrik De Raeve; Pedro Couck; Frans K Gorus; Peter I Croucher; Ben Van Camp
The 5T2MM murine model of multiple myeloma: maintenance and analysis.
Methods in molecular medicine 2005;113():191-205.
2004: Jan E Van Autreve; Ilse Weets; Béatrice Gulbis; Françoise Vertongen; Frans K Gorus; Bart J R Van der Auwera
The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects.
Human immunology 2004;65(7):729-36.
2004: Ilse Weets; Leonard Kaufman; Bart J R Van der Auwera; laurent crenier; Raoul P A Rooman; Christophe E M De Block; K Casteels; E Weber; MI Coeckelberghs; Z Laron; Daniel G Pipeleers; Frans K Gorus
Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.
Diabetologia 2004;47(4):614-21.
2003: Frans K Gorus; Ilse Weets; Katelijn Decochez; Bart J R Van der Auwera
[Preventative biology of type 1 diabetes: implications for clinical preventative studies].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2003;65(4):203-29; discussion 229-31.
2002: Katelijn Decochez; Ivo H De Leeuw; Bart Keymeulen; Chantal Mathieu; Raoul Rottiers; Ilse Weets; Evy Vandemeulebroucke; I Truyen; Leonard Kaufman; Frans Schuit; Daniel G Pipeleers; Frans K Gorus
IA-2 autoantibodies predict impending type I diabetes in siblings of patients.
Diabetologia 2002;45(12):1658-66.
2002: Michael Aleksander Pani; Jan E Van Autreve; Bart J R Van der Auwera; Frans K Gorus; Klaus Badenhoop
Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules.
Diabetologia 2002;45(9):1340-3.
2002: Ilse Weets; Valerie Siraux; Jean-Claude Daubresse; Ivo H De Leeuw; Francoise Féry; Bart Keymeulen; Georges Krzentowski; Michel Letiexhe; Chantal Mathieu; Frank Nobels; Raoul Rottiers; André Scheen; Luc Van Gaal; Frans Schuit; Bart J R Van der Auwera; Mao Rui; Pieter De Pauw; Leonard Kaufman; Frans K Gorus
Relation between disease phenotype and HLA-DQ genotype in diabetic patients diagnosed in early adulthood.
The Journal of clinical endocrinology and metabolism 2002;87(6):2597-605.
2002: Ilse Weets; Ivo H De Leeuw; Marc V L Du Caju; Raoul P A Rooman; Bart Keymeulen; Chantal Mathieu; Raoul Rottiers; Jean-Claude Daubresse; Danielle Rocour-Brumioul; Daniel G Pipeleers; Frans K Gorus
The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation.
Diabetes care 2002;25(5):840-6.
2002: Roxane Claeys; Stephanie Vinken; Herbert Spapen; Kristien ver Elst; Katelijn Decochez; Luc Huyghens; Frans K Gorus
Plasma procalcitonin and C-reactive protein in acute septic shock: clinical and biological correlates.
Critical care medicine 2002;30(4):757-62.
2002: Frederic Winnock; Zhidong Ling; Rene De Proft; Sandra Dejonghe; Frans Schuit; Frans K Gorus; Daniel Pipeleers
Correlation between GABA release from rat islet beta-cells and their metabolic state.
American journal of physiology. Endocrinology and metabolism 2002;282(4):E937-42.
2002: Katrin Bieda; Michael Aleksander Pani; Bart J R Van der Auwera; Christian Seidl; Ralf R Tönjes; Frans K Gorus; Klaus-H Usadel; Klaus Badenhoop
A retroviral long terminal repeat adjacent to the HLA DQB1 gene (DQ-LTR13) modifies Type I diabetes susceptibility on high risk DQ haplotypes.
Diabetologia 2002;45(3):443-7.
2002: Frans K Gorus; Ilse Weets; Daniel G Pipeleers
To: T.J. Wilkin (2001) The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia 44: 914-921.
Diabetologia 2002;45(2):288-9; author reply 289.
2002: Bart J R Van der Auwera; Frans Schuit; Ilse Weets; Ann Ivens; Jan E Van Autreve; Frans K Gorus
Relative and absolute HLA-DQA1-DQB1 linked risk for developing type I diabetes before 40 years of age in the Belgian population: implications for future prevention studies.
Human immunology 2002;63(1):40-50.
2001: Christophe E M De Block; Ivo H De Leeuw; Jan Vertommen; Raoul P A Rooman; Marc V L Du Caju; Christel Van Campenhout; Joost Weyler; Frederic Winnock; Jan E Van Autreve; Frans K Gorus
Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes.
Clinical and experimental immunology 2001;126(2):236-41.
2001: Xavier Bossuyt; Roxane Claeys; Guy Bogaert; H I Said; C Wouters; C Groven; L Sneyers; Godelieve Mariën; Frans K Gorus
Reference values for the five electrophoretic serum protein fractions in Caucasian children by capillary zone electrophoresis.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2001;39(10):970-2.
2001: Frans K Gorus; Daniel G Pipeleers
Prospects for predicting and stopping the development of type 1 of diabetes.
Best practice & research. Clinical endocrinology & metabolism 2001;15(3):371-89.
2001: Christophe E M De Block; Ivo H De Leeuw; Katelijn Decochez; Frederic Winnock; Jan E Van Autreve; Christel Van Campenhout; Manou Martin; Frans K Gorus
The presence of thyrogastric antibodies in first degree relatives of type 1 diabetic patients is associated with age and proband antibody status.
The Journal of clinical endocrinology and metabolism 2001;86(9):4358-63.
2001: Frederic Winnock; Michael R Christie; Manou R Batstra; Henk-Jan Aanstoot; Ilse Weets; Katelijn Decochez; P Jopart; D Nicolaij; Frans K Gorus
Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies.
Diabetes care 2001;24(7):1181-6.
2001: Roxane Claeys; C Groven; Frans K Gorus
Capillary zone electrophoresis of proteins in body fluids: comparison of capillary and agarose gel electrophoresis.
Clinical chemistry 2001;47(5):967-70.
2001: Ilse Weets; Jan E Van Autreve; Bart J R Van der Auwera; Frans Schuit; Marc V L Du Caju; Katelijn Decochez; Ivo H De Leeuw; Bart Keymeulen; Chantal Mathieu; Raoul Rottiers; H Dorchy; Erik Quartier; Frans K Gorus
Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index.
Diabetologia 2001;44(1):40-7.
2000: Katelijn Decochez; J Tits; J L Coolens; Luc Van Gaal; Georges Krzentowski; Frederic Winnock; E Anckaert; Ilse Weets; Daniel G Pipeleers; Frans K Gorus
High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry.
Diabetes care 2000;23(6):838-44.
2000: Kristien ver Elst; Herbert Spapen; Duc Nam Nguyen; Christian Hubert Garbar; Luc Huyghens; Frans K Gorus
Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock.
Clinical chemistry 2000;46(5):650-7.
1999: Kristien ver Elst; J P Chapelle; P Boland; J S Demolder; Frans K Gorus
Analytic and clinical evaluation of the Abbott AxSYM cardiac troponin I assay.
American journal of clinical pathology 1999;112(6):745-52.
1998: Bart Keymeulen; Zhidong Ling; Frans K Gorus; Georges Delvaux; Luc Bouwens; Annick Y Grupping; Christel Hendrieckx; Miriam Pipeleers-Marichal; Chris Van Schravendijk; K Salmela; Daniel G Pipeleers
Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft.
Diabetologia 1998;41(4):452-9.
1998: Pejman Hanifi-Moghaddam; P de Knijf; Bart O Roep; Bart J R Van der Auwera; Albert M I H Naipal; Frans K Gorus; Frans Schuit; Marius J Giphart
Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry.
Diabetes 1998;47(2):263-9.
1998: Frans K Gorus; CL Vandewalle; Frederic Winnock; F Lebleu; Bart Keymeulen; Bart J R Van der Auwera; Alberto Falorni; H Dorchy; Francoise Féry; Daniel G Pipeleers
Increased prevalence of abnormal immunoglobulin M, G, and A concentrations at clinical onset of insulin-dependent diabetes mellitus: a registry-based study. The Belgian Diabetes Registry.
Pancreas 1998;16(1):50-9.
1997: Erik Gerlo; Frans K Gorus
Calibration of ion-exchange HPLC measurements of glycohemoglobin: effect on interassay precision.
Clinical chemistry 1997;43(12):2353-7.
1997: Bart J R Van der Auwera; CL Vandewalle; F C Schuit; Frederic Winnock; Ivo H De Leeuw; S Van Imschoot; G Lamberigts; Frans K Gorus
CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.
Clinical and experimental immunology 1997;110(1):98-103.
1997: CL Vandewalle; MI Coeckelberghs; Ivo H De Leeuw; Marc V L Du Caju; Frans Schuit; Daniel G Pipeleers; Frans K Gorus
Epidemiology, clinical aspects, and biology of IDDM patients under age 40 years. Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry.
Diabetes care 1997;20(10):1556-61.
1997: CL Vandewalle; Alberto Falorni; A Lernmark; P Goubert; H Dorchy; W Coucke; C Semakula; Bart J R Van der Auwera; Leonard Kaufman; Frans Schuit; Daniel G Pipeleers; Frans K Gorus
Associations of GAD65- and IA-2- autoantibodies with genetic risk markers in new-onset IDDM patients and their siblings. The Belgian Diabetes Registry.
Diabetes care 1997;20(10):1547-52.
1997: PH Moghaddam; Aeilko H Zwinderman; P de Knijff; Bart O Roep; RF Schipper; Bart J R Van der Auwera; Albert M I H Naipal; Frans K Gorus; Frans Schuit; Marius J Giphart
TNFa microsatellite polymorphism modulates the risk of IDDM in Caucasians with the high-risk genotype HLA DQA1*0501-DQB1*0201/DQA1*0301-DQB1*0302. Belgian Diabetes Registry.
Diabetes 1997;46(9):1514-5.
1997: Alberto Falorni; Stefano Laureti; A Nikoshkov; M L Picchio; B Hallengren; CL Vandewalle; Frans K Gorus; Cristina Tortoioli; Holger Luthman; Paolo Brunetti; Fausto Santeusanio
21-hydroxylase autoantibodies in adult patients with endocrine autoimmune diseases are highly specific for Addison's disease. Belgian Diabetes Registry.
Clinical and experimental immunology 1997;107(2):341-6.
1997: Frans K Gorus; P Goubert; C Semakula; CL Vandewalle; Jean De Schepper; A Scheen; Michael R Christie; Daniel G Pipeleers
IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry.
Diabetologia 1997;40(1):95-9.
1996: Bart Keymeulen; G Korbutt; M De Paepe; Frans K Gorus; G Klöppel; Daniel G Pipeleers
Long-term metabolic control by rat islet grafts depends on the composition of the implant.
Diabetes 1996;45(12):1814-21.
1996: Lorenza Nisticò; Raffaella Buzzetti; L E Pritchard; Bart J R Van der Auwera; Cristiano Giovannini; E Bosi; M T Larrad; M S Rios; C C Chow; C S Cockram; K Jacobs; Catherine H Mijovic; S C Bain; Anthony H Barnett; CL Vandewalle; Frans Schuit; Frans K Gorus; Roberto Tosi; Paolo Pozzilli; John A Todd
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.
Human molecular genetics 1996;5(7):1075-80.
1996: I Weets; Frans K Gorus; E Gerlo
Evaluation of an immunoturbidimetric assay for haemoglobin A1c on a Cobas Mira S analyser.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1996;34(5):449-53.
1996: C Semakula; CL Vandewalle; Chris Van Schravendijk; J C Sodoyez; Frans Schuit; A Foriers; Alberto Falorni; M Craen; P Decraene; Daniel G Pipeleers; Frans K Gorus
Abnormal circulating pancreatic enzyme activities in more than twenty-five percent of recent-onset insulin-dependent diabetic patients: association of hyperlipasemia with high-titer islet cell antibodies. Belgian Diabetes Registry.
Pancreas 1996;12(4):321-33.
1996: R Denis; J L Wayenberg; M Vermeulen; Frans K Gorus; Erik Gerlo; Willy Lissens; I Liebaers; E Jauniaux; E Vamos
Hyperphosphatasemia in early diagnosed infantile GM1 gangliosidosis presenting as transient hydrops fetalis.
Acta clinica Belgica 1996;51(5):320-7.
1995: Bart J R Van der Auwera; Frans Schuit; I Lyaruu; Alberto Falorni; S Svanholm; CL Vandewalle; Frans K Gorus
Genetic susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk. Belgian Diabetes Registry.
The Journal of clinical endocrinology and metabolism 1995;80(9):2567-73.
1995: Bart J R Van der Auwera; C Van Waeyenberge; Frans Schuit; Harry Heimberg; CL Vandewalle; Frans K Gorus; J Flament
DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.
Diabetes 1995;44(5):527-30.
1995: CL Vandewalle; Alberto Falorni; S Svanholm; A Lernmark; Daniel G Pipeleers; Frans K Gorus
High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry.
The Journal of clinical endocrinology and metabolism 1995;80(3):846-51.
1994: N Devleeschouwer; J C Libeer; J Schiettecatte; V Maes; J Demolder; P M Debusschere; Frans K Gorus
Positive interference of merthiolate in the TDx digoxin assay in control samples used in the Belgian External Quality Assessment (EQA) Scheme.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1994;32(12):935-7.
1994: Frans K Gorus; CL Vandewalle; H Dorchy; P Van Crombrugge; Frans Schuit; Daniel G Pipeleers
Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DAQ1*0301-DQB1*0302 in siblings of patients with type 1 (insulin-dependent) diabetes mellitus. Belgian Diabetes Registry.
The Journal of clinical endocrinology and metabolism 1994;78(5):1172-8.
1993: CL Vandewalle; T Decraene; Frans Schuit; Ivo H De Leeuw; Daniel G Pipeleers; Frans K Gorus
Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years. The Belgian Diabetes Registry.
Diabetologia 1993;36(11):1155-62.
1993: Bart Keymeulen; M Vetri; Frans K Gorus; B Vanbrabandt; Daniel G Pipeleers
The effect of insulin treatment on function of intraportally grafted islets in streptozotocin-diabetic rats.
Transplantation 1993;56(1):60-4.
1993: Frans K Gorus; M Van Blerk
Ektachem slides overestimate serum albumin in patients with nephrotic syndrome.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1993;31(3):159-63.
1993: Frans K Gorus; J Anselmo; Bart Keymeulen
Type 1 (insulin-dependent) diabetes mellitus: an autoimmune, predictable and preventable disease? Lessons from national registries and new challenges to clinical biology.
Acta clinica Belgica 1993;48(2):96-108.
1992: M Van Blerk; V Maes; Luc Huyghens; M P Derde; R Meert; Frans K Gorus
Analytical and clinical evaluation of creatine kinase MB mass assay by IMx: comparison with MB isoenzyme activity and serum myoglobin for early diagnosis of myocardial infarction.
Clinical chemistry 1992;38(12):2380-6.
1992: A Kempinaire; M Laureys; W Goedhuys; L Demeulemeester; C Sevens; J Smeyers-Verbeke; W Cooreman; Hugo Neels; Frans K Gorus
Spuriously low concentrations of serum iron measured with generation 14 Kodak Ektachem slides: prevalence, possible causes, and partial improvement with generation 16 slides.
Clinical chemistry 1992;38(12):2457-64.
1992: Frans K Gorus; J C Sodoyez; Daniel G Pipeleers; Bart Keymeulen; A Foriers; Chris Van Schravendijk
Detection of autoantibodies against islet amyloid polypeptide in human serum. Lack of association with type 1 (insulin-dependent) diabetes mellitus, or with conditions favouring amyloid deposition in islets. The Belgian Diabetes Registry.
Diabetologia 1992;35(11):1080-6.
1992: T Decraene; CL Vandewalle; D Pipeleers; Frans K Gorus
Increased concentrations of total IgM at clinical onset of type 1 (insulin-dependent) diabetes: correlation with IgM binding to cells. The Belgian Diabetes Registry.
Clinical chemistry 1992;38(9):1762-7.
1992: Bart Keymeulen; H Teng; M Vetri; Frans K Gorus; P In't Veld; Daniel G Pipeleers
Effect of donor islet mass on metabolic normalization in streptozotocin-diabetic rats.
Diabetologia 1992;35(8):719-24.
1992: J Schots; H De Raeve; A Boeyckens; V Umbrain; F Verbeek; Frans K Gorus
Method-dependent differences in apparent sodium concentrations in plasma after exchange transfusions with citrated blood.
Clinical chemistry 1992;38(4):558-62.
1992: Christian Demanet; W Goedhuys; M Haentjens; Luc Huyghens; V Blaton; Frans K Gorus
Two automated fully enzymatic assays for lipase activity in serum compared: positive interference from post-heparin lipase activity.
Clinical chemistry 1992;38(2):288-92.
1992: A Boeyckens; J Schots; H Vandenplas; F Senesael; W Goedhuys; Frans K Gorus
Ektachem slides for direct potentiometric determination of sodium in plasma: effect of natremia, blood pH, and type of electrolyte reference fluid on concordance with flame photometry and other potentiometric methods.
Clinical chemistry 1992;38(1):114-8.
1992: R Denis; J L Wayemberg; M Vermeulen; Frans K Gorus; I Liebaers; E Vamos
Hyperphosphatasemia in GM1 gangliosidosis.
The Journal of pediatrics 1992;120(1):164.
1991: M Laureys; J P Sion; H Slabbynck; L Steenssens; C Cobbaert; M P Derde; Frans K Gorus
Macromolecular creatine kinase type 1: a serum marker associated with disease.
Clinical chemistry 1991;37(3):430-4.
1990: M Vercammen; W Goedhuys; A Boeyckens; R De Roy; J Sennesael; C Sevens; Frans K Gorus
Iron and total iron-binding capacity in serum of patients receiving iron-dextran: Kodak Ektachem methodologies, spectrophotometry, and atomic-absorption spectrometry compared.
Clinical chemistry 1990;36(10):1812-5.
1990: Frans K Gorus; L De Pree
Effect of isoenzyme composition on Kodak Ektachem test results for creatine kinase, lactate dehydrogenase, alkaline phosphatase, and amylase.
Clinical chemistry 1990;36(4):685-6.
1990: I Wybo; M Van Blerk; R Malfait; P Goubert; Frans K Gorus
Oligoclonal bands in cerebrospinal fluid detected by PhastSystem isoelectric focusing.
Clinical chemistry 1990;36(1):123-5.
1989: J P Sion; M Laureys; Erik Gerlo; Frans K Gorus
Detection of macroenzymes in serum by high-performance gel permeation chromatography.
Journal of chromatography 1989;496(1):91-100.
1989: O Segers; Frans K Gorus; G Somers; M Van de Winkel; M Vercammen; Daniel Pipeleers
Cell surface antibodies in type 1 (insulin-dependent) diabetic patients. II. Presence of immunoglobulins M which bind to lymphocytes.
Diabetologia 1989;32(8):618-23.
1989: M Vercammen; Frans K Gorus; A Foriers; O Segers; G Somers; M Van de Winkel; Daniel Pipeleers
Cell surface antibodies in type 1 (insulin-dependent) diabetic patients. I. Presence of immunoglobulins M which bind to rat pituitary cells.
Diabetologia 1989;32(8):611-7.
1988: J De Schepper; M P Derde; P Goubert; Frans K Gorus
Reference values for fructosamine concentrations in children's sera: influence of protein concentration, age, and sex.
Clinical chemistry 1988;34(12):2444-7.
1988: Frans K Gorus; Frans Schuit; P A In't Veld; W Gepts; Daniel G Pipeleers
Interaction of sulfonylureas with pancreatic beta-cells. A study with glyburide.
Diabetes 1988;37(8):1090-5.
1988: Frans K Gorus; V Claessens; P Goubert; M Laureys
A sensitive bioluminescent immunoinhibition test for CK-B subunit activity and a CK-MB specific ELISA compared: correlation with agarose electrophoresis and influence of CK-isoenzyme profile on results.
Clinical chemistry 1988;34(7):1474-8.
1987: Erik Gerlo; Frans K Gorus; K De Meirleir
Automated micro-method for determining L-(+)-lactate in arterialized whole blood.
Clinical chemistry 1987;33(1):188-9.
1986: Frans K Gorus; L Deruyter; B De Waele; C Sevens
Agarose electrophoresis and inhibitor tests for isoamylase determination can give complementary clinical information.
Clinical chemistry 1986;32(2):398-400.
1986: K de Meirleir; N Naaktgeboren; A Van Steirteghem; Frans K Gorus; J Olbrecht; P Block
Beta-endorphin and ACTH levels in peripheral blood during and after aerobic and anaerobic exercise.
European journal of applied physiology and occupational physiology 1986;55(1):5-8.
1985: R Malfait; Frans K Gorus; C Sevens
Electrophoresis of serum protein to detect alpha 1-antitrypsin deficiency: five illustrative cases.
Clinical chemistry 1985;31(8):1397-9.