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Rainer Gosert

Research Profile

Physiology

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Polyomavirus Infections

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Jens Kuhle; Eugene O Major; Ernst-Wilhelm Radue; C Ryschkewitsch; R Sutter; Ozgür Yaldizli; R Bühler; Tobias Derfuss; S Frank; Rainer Gosert; Ludwig Kappos; Hans Hirsch
Management and outcome of CSF-JC virus PCR-negative PML in a natalizumab-treated patient with MS.
Rainer Gosert; Christine Hanssen Rinaldo; Marion Wernli; Eugene O Major; Hans H Hirsch
CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes.
Christine Hanssen Rinaldo; Rainer Gosert; Eva Bernhoff; Solrun Finstad; Hans H Hirsch
1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells.

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All Publications

2011: Jens Kuhle; Eugene O Major; Ernst-Wilhelm Radue; C Ryschkewitsch; R Sutter; Ozgür Yaldizli; R Bühler; Tobias Derfuss; S Frank; Rainer Gosert; Ludwig Kappos; Hans Hirsch
Management and outcome of CSF-JC virus PCR-negative PML in a natalizumab-treated patient with MS.
Neurology 2011;77(23):2010-6.
2011: Rainer Gosert; Christine Hanssen Rinaldo; Marion Wernli; Eugene O Major; Hans H Hirsch
CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes.
Antimicrobial agents and chemotherapy 2011;55(5):2129-36.
2010: Christine Hanssen Rinaldo; Rainer Gosert; Eva Bernhoff; Solrun Finstad; Hans H Hirsch
1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells.
Antimicrobial agents and chemotherapy 2010;54(11):4714-22.
2010: Rainer Gosert; Piotr Kardas; Eugene O Major; Hans Hirsch
Rearranged JC virus noncoding control regions found in progressive multifocal leukoencephalopathy patient samples increase virus early gene expression and replication rate.
Journal of virology 2010;84(20):10448-56.
2010: Gunhild Unterstab; Rainer Gosert; David Leuenberger; Pascal Lorentz; Christine Hanssen Rinaldo; Hans H Hirsch
The polyomavirus BK agnoprotein co-localizes with lipid droplets.
Virology 2010;399(2):322-31.
2010: Marit Renée Myhre; Gunn-Hege Olsen; Rainer Gosert; Hans H Hirsch; Christine Hanssen Rinaldo
Clinical polyomavirus BK variants with agnogene deletion are non-functional but rescued by trans-complementation.
Virology 2010;398(1):12-20.
2009: Bodaghi Sohrab; Patrizia Comoli; Robert Bösch; Alberta Azzi; Rainer Gosert; David Leuenberger; Fabrizio Ginevri; Hans Hirsch
Antibody responses to recombinant polyomavirus BK large T and VP1 proteins in young kidney transplant patients.
Journal of clinical microbiology 2009;47(8):2577-85.
2009: Adrian Egli; Laura Infanti; Alexis Dumoulin; Andreas Buser; Jacqueline Samaridis; Christine Stebler; Rainer Gosert; Hans Hirsch
Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors.
The Journal of infectious diseases 2009;199(6):837-46.
2009: Volker Brass; Rainer Gosert; Darius Moradpour
Investigation of the hepatitis C virus replication complex.
Methods in molecular biology (Clifton, N.J.) 2009;510():195-209.
2008: Georg A Funk; Rainer Gosert; P Comoli; Fabrizio Ginevri; Hans Hirsch
Polyomavirus BK replication dynamics in vivo and in silico to predict cytopathology and viral clearance in kidney transplants.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(11):2368-77.
2008: Rainer Gosert; Christine Hanssen Rinaldo; Georg A Funk; Adrian Egli; Emilio Ramos; Cinthia Drachenberg; Hans Hirsch
Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology.
The Journal of experimental medicine 2008;205(4):841-52.
2007: Adrian Egli; Simone Binggeli; Bodaghi Sohrab; Alexis Dumoulin; Georg A Funk; Nina Khanna; David Leuenberger; Rainer Gosert; Hans Hirsch
Cytomegalovirus and polyomavirus BK posttransplant.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22 Suppl 8():viii72-viii82.
2007: Cinthia Drachenberg; Hans Hirsch; John C Papadimitriou; Rainer Gosert; Ravinder K Wali; Raghava Munivenkatappa; Joseph Nogueira; Charles B Cangro; Abdolreza Haririan; Susan R Mendley; Emilio Ramos
Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation.
Transplantation 2007;84(3):323-30.
2007: David Leuenberger; Per Arne Andresen; Rainer Gosert; Simone Binggeli; Erik Strom; Bodaghi Sohrab; Christine Hanssen Rinaldo; Hans Hirsch
Human polyomavirus type 1 (BK virus) agnoprotein is abundantly expressed but immunologically ignored.
Clinical and vaccine immunology : CVI 2007;14(8):959-68.
2007: Georg A Funk; Rainer Gosert; Hans Hirsch
Viral dynamics in transplant patients: implications for disease.
The Lancet infectious diseases 2007;7(7):460-72.
2006: Maurizio Provenzano; Laura Bracci; Stephen Wyler; Tvrtko Hudolin; Giovanni Sais; Rainer Gosert; Paul Zajac; Giorgio Palu'; Michael Heberer; Hans Hirsch; Giulio C Spagnoli
Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors.
Journal of translational medicine 2006;4():47.
2005: Rainer Gosert; Wiebke Jendrsczok; Jan Martin Berke; Volker Brass; Hubert E Blum; Darius Moradpour
Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein.
Journal of virology 2005;79(12):7911-7.
2005: Yuri Kusov; Rainer Gosert; Verena Gauss-Müller
Replication and in vivo repair of the hepatitis A virus genome lacking the poly(A) tail.
The Journal of general virology 2005;86(Pt 5):1363-8.
2004: Darius Moradpour; Volker Brass; Elke Bieck; Peter Friebe; Rainer Gosert; Hubert E Blum; Ralf Bartenschlager; François Penin; Volker Lohmann
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication.
Journal of virology 2004;78(23):13278-84.
2004: Darius Moradpour; Matthew J Evans; Rainer Gosert; Zhenghong Yuan; Hubert E Blum; Stephen P Goff; Brett D Lindenbach; Charles M Rice
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes.
Journal of virology 2004;78(14):7400-9.
2003: Darius Moradpour; Rainer Gosert; Denise Egger; François Penin; Hubert E Blum; Kurt Bienz
Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex.
Antiviral research 2003;60(2):103-9.
2003: Rainer Gosert; Denise Egger; Volker Lohmann; Ralf Bartenschlager; Hubert E Blum; Kurt Bienz; Darius Moradpour
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons.
Journal of virology 2003;77(9):5487-92.
2002: Darius Moradpour; Volker Brass; Rainer Gosert; Benno Wölk; Hubert E Blum
[Molecular virology of hepatitis C].
Praxis 2002;91(51-52):2247-53.
2002: Darius Moradpour; Volker Brass; Rainer Gosert; Benno Wölk; Hubert E Blum
Hepatitis C: molecular virology and antiviral targets.
Trends in molecular medicine 2002;8(10):476-82.
2002: Rainer Gosert; Darius Moradpour
Reading between the lines: evidence for a new hepatitis C virus protein.
Hepatology (Baltimore, Md.) 2002;36(3):757-60.
2002: Denise Egger; Benno Wölk; Rainer Gosert; Leonardo Bianchi; Hubert E Blum; Darius Moradpour; Kurt Bienz
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex.
Journal of virology 2002;76(12):5974-84.
2002: Rainer Gosert; Amornrat Kanjanahaluethai; Denise Egger; Kurt Bienz; Susan C Baker
RNA replication of mouse hepatitis virus takes place at double-membrane vesicles.
Journal of virology 2002;76(8):3697-708.
2002: Rainer Gosert; Darius Moradpour
A new twist to translation initiation of the hepatitis C virus.
Hepatology (Baltimore, Md.) 2002;35(3):724-6.
2002: Hervé Lerat; Masao Honda; Michael R Beard; Kim Loesch; Jiaren Sun; Yan Yang; Michiari Okuda; Rainer Gosert; Shu-Yuan Xiao; Steven Weinman; Stanley M Lemon
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.
Gastroenterology 2002;122(2):352-65.
2001: R C Rust; Lukas Landmann; Rainer Gosert; B L Tang; Wanjin Hong; Hans-Peter Hauri; Denise Egger; Kurt Bienz
Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex.
Journal of virology 2001;75(20):9808-18.
2001: Rainer Gosert; Amornrat Kanjanahaluethai; Denise Egger; Kurt Bienz; Susan C Baker
Comparison of replicase localization in different types of mouse hepatitis virus (MHV)-infected cells.
Advances in experimental medicine and biology 2001;494():275-81.
2000: Rainer Gosert; K H Chang; Rene Rijnbrand; M Yi; David V Sangar; Stanley M Lemon
Transient expression of cellular polypyrimidine-tract binding protein stimulates cap-independent translation directed by both picornaviral and flaviviral internal ribosome entry sites In vivo.
Molecular and cellular biology 2000;20(5):1583-95.
2000: Rainer Gosert; Denise Egger; Kurt Bienz
A cytopathic and a cell culture adapted hepatitis A virus strain differ in cell killing but not in intracellular membrane rearrangements.
Virology 2000;266(1):157-69.
1998: R Bolten; Denise Egger; Rainer Gosert; G Schaub; Lukas Landmann; Kurt Bienz
Intracellular localization of poliovirus plus- and minus-strand RNA visualized by strand-specific fluorescent In situ hybridization.
Journal of virology 1998;72(11):8578-85.